Tomidokoro Yasushi 冨所康志

… Alternative Names

TOMIDOKORO Yasushi 冨所康志

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Researcher Number	80447250
Other IDs
Affiliation (Current)	2025: 筑波大学, 医学医療系, 講師
Affiliation (based on the past Project Information) *help	2024: 筑波大学, 医学医療系, 講師 2012 – 2018: 筑波大学, 医学医療系, 講師 2007 – 2010: University of Tsukuba, Graduate School of Comprehensive HumanSciences, Assistant Professor
Review Section/Research Field	Principal Investigator Neurology / Basic Section 52010:General internal medicine-related Except Principal Investigator Neurology / Biological Sciences
Keywords	Principal Investigator 認知症 / 診断マーカー / アルツハイマー病 / Alzheimer病 / 脳神経疾患 / 診断指標 / タウ / Aβ / 脳脊髄液 / リン酸化タウ … More / 毒性コンホマー / アミロイドベータ / 治療 / アミロイド … More Except Principal Investigator アミロイドβ蛋白 / アルツハイマー病 / 酸化ストレス / oxidative stress / amyloid β protein / Alzheimer's disease / APP / BACE1 / ミトコンドリア / 内科 / 脳神経疾患 / 痴呆 / ストレス / 老化 / アポリポ蛋白E / γ-セクレターゼ / β-セクレターゼ / α-セクレターゼ / アミロイドβ前駆体蛋白 / リソゾーム / 転写因子EB / オートファジー・リソソーム経路 / アミロイドβ蛋白前駆体 / transcription factor EB / lysosome / autophagy / amyloid precursor / mitochondria / knock-in mouse / konck-out mouse / lipid raft / hypoperfusion / apolipoprotein E / ノックインマウス / ノックアウトマウス / 脂質ラフト / 低灌流 / アポリポ蛋白 E / アミロイド前駆体蛋白（APP） / γ-secretase / αBクリスタリ / αBクリスタリン / 認知症 / 白内障 / 水晶体 Less

アルツハイマー病の予防的治療にむけたAβ毒性コンホマーによる血液マーカーの開発Principal Investigator
- Principal Investigator
  
  冨所康志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  University of Tsukuba
Analuses of mitochondrial dysfunction depending on the species of pathogenic molecules in Alzheimer's disease
- Principal Investigator
  
  Tamaoka Akira
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  University of Tsukuba
Abeta toxic conformer as a candidate of noble surrogate marker of Alzheimer diseasePrincipal Investigator
- Principal Investigator
  
  Tomidokoro Yasushi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  University of Tsukuba
Trial to develop oxidative stress erasing therapy to treat Alzheimer disease using redox nanoparticlesPrincipal Investigator
- Principal Investigator
  
  Tomidokoro Yasushi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  University of Tsukuba
Pathophysiology of Alzheimer's disease and mitochondrial dysfunction
- Principal Investigator
  
  TAMAOKA Akira
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  University of Tsukuba
Analyses of amyloid protein in lens in correlation with cognitive function
- Principal Investigator
  
  TAMAOKA Akira
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  University of Tsukuba
酸化ストレスによるBACE1発現変化とアミロイドβ蛋白との相関に関する解析
- Principal Investigator
  
  TAMAOKA Akira
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Analyses on oxidative stress and amyloid β protein in brains of mice with modified apolipoprotein E gene
- Principal Investigator
  
  TAMAOKA Akira
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  University of Tsukuba

All 2019 2018 2017 2015 2014 2013 2010 2009 2007 Other

All Journal Article Presentation

[Journal Article] Intravascular large B-cell lymphoma presenting with hearing loss and dizziness: A case report.2019
- Author(s)
  Miyake Z, Tomidokoro Y, Tsurubuchi T, Matsumura A, Sakamoto N, Noguchi M, Tamaoka A.
- Journal Title
  
  Medicine (Baltimore)
  
  Volume: 98 Issue: 7 Pages: e14470-e14470
- DOI
  10.1097/md.0000000000014470
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15476
[Journal Article] Chronic treatment with a smart antioxidative nanoparticle for inhibition of amyloid plaque propagation in Tg2576 mouse model of Alzheimer’s disease2017
- Author(s)
  Boonruamkaew Phetcharat、Chonpathompikunlert Pennapa、Vong Long Binh、Sakaue Sho、Tomidokoro Yasushi、Ishii Kazuhiro、Tamaoka Akira、Nagasaki Yukio
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 3785-3785
- DOI
  10.1038/s41598-017-03411-7
- NAID
  120007128892
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09664, KAKENHI-PROJECT-25220203, KAKENHI-PROJECT-16K15628
[Journal Article] Glossopharyngeal nerve and vagus nerve palsies associated with influenza vaccination2014
- Author(s)
  Ishii K, Kanazawa T, Tomidokoro Y, Tamaoka A
- Journal Title
  
  Intern Med
  
  Volume: 53(3) Pages: 259-261
- NAID
  130003392628
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591249
[Journal Article] Statins reduce amyloid β-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons2013
- Author(s)
  Hosaka A, Araki W, Oda A, Tomidokoro Y, Tamaoka A
- Journal Title
  
  Neurochem Res
  
  Volume: 38 Issue: 3 Pages: 589-600
- DOI
  10.1007/s11064-012-0956-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590951, KAKENHI-PROJECT-24591249
[Journal Article] Pyroglutamate formation at the N-termini of ABri molecules in familial British dementia is not restricted to the central nervous system2010
- Author(s)
  Tomidokoro Y, Tamaoka A, Holton JL, Lashley T, Frangione B, Revesz T, Rostagno A, Ghiso J
- Journal Title
  
  Hirosaki Igaku 61(Suppl)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590987
[Journal Article] Pyroglutamate formation at the N-termini of ABri molecules in familial British dementia is not restricted to the central nervous system.2010
- Author(s)
  Tomidokoro Y
- Journal Title
  
  Hirosaki Igaku
  
  Volume: 61(Suppl)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590987
[Presentation] Toxic Aβ conformer and tau in CSF obtained from the cases of AD dementia, a preliminary study2018
- Author(s)
  Yasushi Tomidokoro, Kazuhiro Ishii, Kazuhiro Irie, Akira Tamaoka
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-16K15476
[Presentation] 性格変化・行動異常にて発症し，顕著なすくみ足が出現した60歳女性例．2018
- Author(s)
  大内翔悟，冨所康志，清水眸，石井賢二，樋口真人，島田斉，須原哲也，玉岡晃
- Organizer
  第224回神経学会関東地方会
- Data Source
  KAKENHI-PROJECT-16K15476
[Presentation] 脳脊髄液中のAβ毒性コンホマー量とタウの関連2018
- Author(s)
  冨所康志，石井一弘，入江一浩，玉岡　晃
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15476
[Presentation] 脳脊髄液中の毒性Aβコンホマーの測定2017
- Author(s)
  冨所康志，石井一弘，入江一浩，玉岡　晃
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15476
[Presentation] 難聴，めまいで発症し，脳生検にて血管内大細胞型B細胞リンパ腫と診断された66歳男性例2017
- Author(s)
  三宅善嗣，冨所康志，野中遥奈，鶴淵隆夫，中馬越真理子，坂本規彰，野口雅之，玉岡晃
- Organizer
  第217回　日本神経学会関東・甲信越地方会
- Data Source
  KAKENHI-PROJECT-16K15476
[Presentation] Posterior cortical atrophyを呈し分子イメージングや脳脊髄液バイオマーカーにより診断したAlzheimer型認知症の63歳例2017
- Author(s)
  遠坂直希，中馬越清隆，冨所康志，石井賢二，樋口真人，島田　斉、須原哲也，玉岡　晃
- Organizer
  第220回日本神経学会関東・甲信越地方会
- Place of Presentation
  砂防会館（東京都千代田区）
- Year and Date
  2017-03-04
- Data Source
  KAKENHI-PROJECT-16K15476
[Presentation] Measurement of toxic Aβ conformer in cerebrospinal fluid obtained from the cases of ad dementia2017
- Author(s)
  Yasushi Tomidokoro, Kazuhiro Ishii, Kazuhiro Irie, Akira Tamaoka
- Organizer
  第58回日本神経学会学術大会（XXIII World Congress of Neurologyと同時開催）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15476
[Presentation] 非認知症神経疾患患者脳ならびに脳脊髄液中の毒性Aβコンホマーの検討2015
- Author(s)
  冨所康志，石井一弘，玉岡　晃
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森、青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-25670416
[Presentation] Toxic Aβ conformer is present in brains and cerebrospinal fluid obtained from non-demented individuals.2015
- Author(s)
  Tomidokoro Y, Ishii K, Tamaoka A
- Organizer
  Alzheimer's Association International Conference 2015
- Place of Presentation
  ワシントンDC（アメリカ合衆国）
- Year and Date
  2015-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25670416
[Presentation] Analysis of toxic Aβ conformer in brains and cerebrospinal fluid obtained from non-demented individuals2015
- Author(s)
  Tomidokoro Y, Ishii K, Tamaoka A
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ、新潟
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-25670416
[Presentation] Biochemical analysis of toxic conformer of Abeta isolated from AD brains2013
- Author(s)
  Yasushi Tomidokoro, Kazuhiro Ishii, Akira Tamaoka
- Organizer
  Alzheimer's Association 2013 International Conference (AAIC)
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-25670416
[Presentation] Alzheimer病患者脳における毒性Abetaコンフォマーの同定2013
- Author(s)
  冨所康志，石井一弘，玉岡　晃
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25670416
[Presentation] 白内障水晶体におけるアミロイドβペプチドの定量化の可能性-非認知症患者検体での検討2010
- Author(s)
  赤松恵,冨所康志,加治優一,大鹿哲郎,玉岡晃
- Organizer
  第29回日本認知症学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2010-11-05
- Data Source
  KAKENHI-PROJECT-20590987
[Presentation] Familial British Dementiaアミロイド分子N末端のピロ化は中枢神経系に限定されない.2010
- Author(s)
  冨所康志
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京国際フォーラム(東京)
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-20590987
[Presentation] 認知症を伴わない白内障患者の水晶体におけるアミロイドβペプチドの解析2010
- Author(s)
  赤松恵,冨所康志,加治優一,大鹿哲郎,玉岡晃
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-20590987
[Presentation] Pyroglutamate formation at the N-terminal of ABri molecules in familial British dementia is not restricyed to the central nervous system.2009
- Author(s)
  Yasushi Tomidokoro
- Organizer
  The 11th Meeting of Hirosaki International Forum of Medical Science
- Place of Presentation
  Hirosaki
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20590987
[Presentation] PYROGLUTAMATE FORMATION AT THE N-TERMINI OF ABRI MOLECULES IN FAMILIAL BRITISH DEMENTIA IS NOT RESTRICTED TO THE CENTRAL NERVOUS SYSTEM.2009
- Author(s)
  Yasushi Tomidokoro
- Organizer
  39th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Chicago(USA)
- Data Source
  KAKENHI-PROJECT-20590987
[Presentation] Familial Danish dementia:co-existence of Danish and Alzheimer amyloid subunits (ADan and Abeta)in the absence of compact plaques.2007
- Author(s)
  Tomidokoro, Y・Tamaoka, A・Frangione, B・Ghiso
- Organizer
  第26回目本認知症学会
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590924
[Presentation] Familial Danish dementia: co-existence of Danish and Alzheimer amy loid subunits (Adan and Abeta) in the absence of compact plaques.2007
- Author(s)
  Tomidokoro, Y., Tamaoka, A., Frangione, B, Ghiso
- Organizer
  第26回日本認知症学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18023008
[Presentation] Familial Danish dementia: co-existence of Danish and Alzheimer amy loid subunits (ADan and Abeta)in the absence of compact plaques.2007
- Author(s)
  Tomidokoro Y, Tamaoka A, Frangione B, Ghiso
- Organizer
  第26回日本認知症学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18590924
[Presentation] Familial Danish dementia : co-existence of Danish and Alzheimer subunits amyloid(ADan and Abeta) in the absence of compact plaques2007
- Author(s)
  Tomidokoro Y
- Organizer
  26th Annual Meeting of Japan Society for Dementia Research
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590924
[Presentation] 毒性Aβコンフォマーのヒト脳ならびに脳脊髄液における生化学的同定の試み
- Author(s)
  冨所康志，石井一弘，玉岡　晃
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25670416
[Presentation] Biochemical analysis of Abeta toxic conformer in human autopsied brains and cerebrospinal fluid
- Author(s)
  Tomidokoro Y, Ishii K, Tamaoka A
- Organizer
  Alzheimer's Association International Conference 2014
- Place of Presentation
  コペンハーゲン
- Year and Date
  2014-07-12 – 2014-07-16
- Data Source
  KAKENHI-PROJECT-25670416
[Presentation] AD脳ならびに脳脊髄液中の毒性Aβコンホマー同定の試み
- Author(s)
  冨所康志，石井一弘，玉岡　晃
- Organizer
  第33回日本認知症学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-25670416

1. TAMAOKA Akira (50192183)

# of Collaborated Projects: 7 results

# of Collaborated Products: 25 results
2. Ishii Kazuhiro (70323293)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
3. 望月昭英 (40301080)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TAKUMA Hiroshi (00326258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Nagasaki Yukio (90198309)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Koide Takuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Irie Kazuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. ARAKI Wataru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. ODA Akiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. HOSAKA Ai

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. ARAKI Yumiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tomidokoro Yasushi 冨所 康志

TOMIDOKORO Yasushi 冨所 康志

Research Projects

Research Products

Co-Researchers

アルツハイマー病の予防的治療にむけたAβ毒性コンホマーによる血液マーカーの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analuses of mitochondrial dysfunction depending on the species of pathogenic molecules in Alzheimer's disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Abeta toxic conformer as a candidate of noble surrogate marker of Alzheimer diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Trial to develop oxidative stress erasing therapy to treat Alzheimer disease using redox nanoparticlesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathophysiology of Alzheimer's disease and mitochondrial dysfunction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of amyloid protein in lens in correlation with cognitive function

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

酸化ストレスによるBACE1発現変化とアミロイドβ蛋白との相関に関する解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analyses on oxidative stress and amyloid β protein in brains of mice with modified apolipoprotein E gene

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Intravascular large B-cell lymphoma presenting with hearing loss and dizziness: A case report.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chronic treatment with a smart antioxidative nanoparticle for inhibition of amyloid plaque propagation in Tg2576 mouse model of Alzheimer’s disease2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Glossopharyngeal nerve and vagus nerve palsies associated with influenza vaccination2014

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Statins reduce amyloid β-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pyroglutamate formation at the N-termini of ABri molecules in familial British dementia is not restricted to the central nervous system2010

Author(s)

Journal Title

Data Source

[Journal Article] Pyroglutamate formation at the N-termini of ABri molecules in familial British dementia is not restricted to the central nervous system.2010

Author(s)

Tomidokoro Yasushi 冨所康志

TOMIDOKORO Yasushi 冨所康志