Kano Mitsunobu 狩野光伸

… Alternative Names

KANO Mitsunobu 狩野光伸

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Researcher Number	80447383
Other IDs
Affiliation (Current)	2025: 岡山大学, ヘルスシステム統合科学学域, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 岡山大学, ヘルスシステム統合科学学域, 教授 2018 – 2020: 岡山大学, ヘルスシステム統合科学研究科, 教授 2016 – 2017: 岡山大学, 医歯薬学総合研究科, 教授 2012 – 2016: 岡山大学, 医歯(薬)学総合研究科, 教授 2011: 東京大学, 医学(系)研究科(研究院), 講師 … More 2008 – 2009: The University of Tokyo, 大学院・医学系研究科, 講師 2008: The University of Tokyo, 大学院医学系研究科, 講師 2007: 大学院, 医学系研究科, 特任助教 2007: The University of Tokyo, 大学院・医学系研究科, 特任助教 Less
Review Section/Research Field	Principal Investigator Experimental pathology / Basic Section 47060:Clinical pharmacy-related / Basic Section 53010:Gastroenterology-related / Applied pharmacology Except Principal Investigator Biomedical engineering/Biomaterial science and engineering / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 90120:Biomaterials-related / Basic Section 58010:Medical management and medical sociology-related / Basic Section 53020:Cardiology-related / Applied pharmacology / Biological Sciences
Keywords	Principal Investigator 膵がん / 線維化 / 膵癌 / 膵星細胞 / 間質 / 腫瘍微小環境 / 三次元培養 / 膵臓がん / ナノバイオ / 線維化障壁 … More / 薬剤送達 / 難治固形腫瘍 / 立体培養 / 膵臓星状細胞（PSC） / 膵臓星状細胞 / 薬物送達 / 線維芽細胞 / 細胞外基質 / 三次元培養法 / 新規モデル / がん / 細胞・組織 / 腫瘍 / ナノ薬理学 / 組織・細胞 / ナノテクノロジー / 血管壁細胞 / 血管内皮細胞 / ナノ粒子 / ナノ薬剤 / 血管透過性 / 新生血管 / ナノDDS / 腫瘍血管 / 癌 / 病理学 … More Except Principal Investigator 再生医療 / オルガノイド / シグナル伝達 / 微小血管イメージング / 体内微細加工 / 機能的血管連結 / 再生医療が / 中空チタンマイクロチューブ / 移植 / 血管連結 / 微小血管 / 高齢者 / データサイエンス / 高齢者医療 / 臨床疫学 / 医療ビッグデータ / 微小血管モデル / 肺動脈平滑筋細胞 / 転写因子 / 肺高血圧 / 灌流培養 / 間質 / 腫瘍 / 三次元組織 / 薬効評価 / 薬物評価 / 脈管構造 / 三次元腫瘍モデル / 組織工学 / 薬剤疫学 / 応用薬理学 / データベース / 臨床疫学研究 / レセプト / 疫学研究 / データベース研究 / 妥当性検証 / 前立腺がん / 観察研究 / レセプトデータベース / 前立腺癌 / Smad7 / DDS / 乳がん / 膵臓がん / がん朝細胞 / 脳腫瘍 / 胃がん / シグナル伝逹 / 血管新生 / 転移 / がん幹細胞 / 分子標的治療 / TGF-β Less

Development of Functional Vascular Connected Organoid Transplantation Technology for Next Generation Regenerative Medicine
- Principal Investigator
  
  山本雅哉
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Tohoku University
Overcoming fibrotic barriers to nanomedicine delivery in pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  狩野光伸
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Okayama University
Development of a vascularized organoids transplantation technology for next-generation regenrative medicine
- Principal Investigator
  
  Yamamoto Masaya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Tohoku University
Clinical epidemiological study on disease structure and quality assessment of healthcare for the older population by utilizing healthcare big data
- Principal Investigator
  
  Koyama Toshihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58010:Medical management and medical sociology-related
- Research Institution
  Okayama University
Analysis of downstream effectors of PDGF signaling to identify novel therapeutic targets in pulmonary hypertension
- Principal Investigator
  
  Matsubara Hiromi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  独立行政法人国立病院機構岡山医療センター(臨床研究部)
Establishing a 3D model of fibrosis in pancreatic cancer and analysis of interaction between tumor cells and stellate cellsPrincipal Investigator
- Principal Investigator
  
  Kano Mitsunobu
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Okayama University
Construction of flow culture system of 3D-Cancer-stromal Tissues for Evaluation of Interaction Between Cancer cells and Immunocytes
- Principal Investigator
  
  Matsusaki Michiya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Osaka University
Development of a method for validating epidemiological research results using a large-scale claim database.
- Principal Investigator
  
  Hinotsu Shiro
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Sapporo Medical University
  Okayama University
Investigation of intractability of pancreatic cancer by using 3D culture of pancreatic stellate cellsPrincipal Investigator
- Principal Investigator
  
  Mitsunobu Kano
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Okayama University
Fabrication of Innovative Human 3D-Tumor Models for In Vitro Evaluation of Cancer Growth, Invation, and Metastasis
- Principal Investigator
  
  Matsusaki Michiya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Osaka University
Molecular Mechanisms in extravasation of nanoDDSPrincipal Investigator
- Principal Investigator
  
  KANO Mitsunobu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Okayama University
  The University of Tokyo
Enhancement of nanoparticle accumulation via regulation of tumor vasculaturePrincipal Investigator
- Principal Investigator
  
  KANO Mitsunobu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokyo
Establishment of New Strategies for Treatment of Cancer Using TGF-beta Signaling
- Principal Investigator
  
  MIYAZONO Kohei
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo

[Book] Stromal barriers within the tumor microenvironment and obstacles to nanomedicine (Cancer Drug Delivery Systems based on the Tumor Microenvironment, Chapter 4)2019
- Author(s)
  Tanaka HY, Kano MR
- Total Pages
  33
- Publisher
  Springer Nature
- ISBN
  9784431568780
- Data Source
  KAKENHI-PROJECT-18H02797
[Book] ＤＤＳ先端技術の製剤への応用開発：ナノDDSを臨床応用するための疾患モデルの開発2017
- Author(s)
  田中啓祥、狩野光伸
- Total Pages
  492
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-26293119
[Journal Article] Targeting ROCK2 improves macromolecular permeability in a 3D fibrotic pancreatic cancer microenvironment model2024
- Author(s)
  Tanaka Hiroyoshi Y.、Nakazawa Takuya、Miyazaki Takuya、Cabral Horacio、Masamune Atsushi、Kano Mitsunobu R.
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 369 Pages: 283-295
- DOI
  10.1016/j.jconrel.2024.03.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06279, KAKENHI-PROJECT-23K27344
[Journal Article] Trends in hepatitis C virus‐associated mortality rates in Japan, 1998-20172021
- Author(s)
  Hagiya Hideharu、Koyama Toshihiro、Deguchi Matsuo、Minato Yusuke、Miura Satomi、Funahashi Tomoko、Teratani Yusuke、Zamami Yoshito、Shinomiya Kazuaki、Kitamura Yoshihisa、Sendo Toshiaki、Hinotsu Shiro、Kano Mitsunobu
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: - Issue: 9 Pages: 2486-2492
- DOI
  10.1111/jgh.15517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06785, KAKENHI-PROJECT-19K10533
[Journal Article] Fibrotic elements within the tumor microenvironment and its implications for nano-drug delivery systems2021
- Author(s)
  田中啓祥、狩野光伸
- Journal Title
  
  Drug Delivery System
  
  Volume: 36 Issue: 4 Pages: 232-240
- DOI
  10.2745/dds.36.232
- NAID
  130008134399
- ISSN
  0913-5006, 1881-2732
- Year and Date
  2021-09-25
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-18H02797, KAKENHI-PROJECT-20K16989
[Journal Article] Population-Based Observational Study of Adverse Drug Event-Related Mortality in the Super-Aged Society of Japan2021
- Author(s)
  Funahashi Tomoko、Koyama Toshihiro、Hagiya Hideharu、Harada Ko、Iinuma Syunya、Ushio Soichiro、Zamami Yoshito、Niimura Takahiro、Shinomiya Kazuaki、Ishizawa Keisuke、Sendo Toshiaki、Hinotsu Shiro、Kano Mitsunobu R.
- Journal Title
  
  Drug Safety
  
  Volume: - Issue: 5 Pages: 531-539
- DOI
  10.1007/s40264-020-01037-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06785, KAKENHI-PROJECT-19K10533, KAKENHI-PROJECT-21H02646
[Journal Article] A multidisciplinary approach to the science of tumor microenvironments2021
- Author(s)
  狩野光伸
- Journal Title
  
  Drug Delivery System
  
  Volume: 36 Issue: 4 Pages: 229-229
- DOI
  10.2745/dds.36.229
- NAID
  130008134397
- ISSN
  0913-5006, 1881-2732
- Year and Date
  2021-09-25
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-18H02797
[Journal Article] Heterotypic 3D pancreatic cancer model with tunable proportion of fibrotic elements2020
- Author(s)
  Tanaka Hiroyoshi Y.、Kurihara Tsuyoshi、Nakazawa Takuya、Matsusaki Michiya、Masamune Atsushi、Kano Mitsunobu R.
- Journal Title
  
  Biomaterials
  
  Volume: 251 Pages: 120077-120077
- DOI
  10.1016/j.biomaterials.2020.120077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16989, KAKENHI-PROJECT-18H02797
[Journal Article] Selection of Tumor models2020
- Author(s)
  Takashima Hiroki、Koga Yoshikatsu、Tsumura Ryo、Fuchigami Hirobumi、Matsumura Yasuhiro、Yasunaga Masahiro、Tanaka Hiroyoshi Y.、Kurihara Tsuyoshi、Kano Mitsunobu R.
- Journal Title
  
  Drug Delivery System
  
  Volume: 35 Issue: 5 Pages: 443-447
- DOI
  10.2745/dds.35.443
- NAID
  130007991323
- ISSN
  0913-5006, 1881-2732
- Year and Date
  2020-11-25
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-20K16989, KAKENHI-PROJECT-18H02797, KAKENHI-PROJECT-18K15297
[Journal Article] 3D in vitro Model of Vascular Medial Thickening in Pulmonary Arterial Hypertension2020
- Author(s)
  Morii Chiharu、Tanaka Hiroyoshi Y.、Izushi Yasuhisa、Nakao Natsumi、Yamamoto Masaya、Matsubara Hiromi、Kano Mitsunobu R.、Ogawa Aiko
- Journal Title
  
  Frontiers in Bioengineering and Biotechnology
  
  Volume: 8 Pages: 482-482
- DOI
  10.3389/fbioe.2020.00482
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20105, KAKENHI-PROJECT-20K08463, KAKENHI-PROJECT-19K17658, KAKENHI-PROJECT-18K08128
[Journal Article] In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers2019
- Author(s)
  Watanabe Sumiyo、Hayashi Kotaro、Toh Kazuko、Kim Hyun Jin、Liu Xueying、Chaya Hiroyuki、Fukushima Shigeto、Katsushima Keisuke、Kondo Yutaka、Uchida Satoshi、Ogura Satomi、Nomoto Takahiro、et al.
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 1894-1894
- DOI
  10.1038/s41467-019-09856-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18383, KAKENHI-PROJECT-17KT0048, KAKENHI-PROJECT-19K12799, KAKENHI-PROJECT-17K20086, KAKENHI-PROJECT-18K18391, KAKENHI-PROJECT-17KK0102, KAKENHI-PROJECT-18H04163, KAKENHI-PROJECT-16H03178, KAKENHI-PROJECT-17H03582, KAKENHI-PROJECT-18H02797, KAKENHI-PROJECT-18H03529, KAKENHI-PROJECT-17H04743, KAKENHI-PROJECT-17K07234, KAKENHI-PROJECT-17H02098
[Journal Article] Place of death trends among patients with dementia in Japan: a population-based observational study2019
- Author(s)
  Koyama Toshihiro、Sasaki Misato、Hagiya Hideharu、Zamami Yoshito、Funahashi Tomoko、Ohshima Ayako、Tatebe Yasuhisa、Mikami Naoko、Shinomiya Kazuaki、Kitamura Yoshihisa、Sendo Toshiaki、Hinotsu Shiro、Kano Mitsunobu R.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 41598-56388
- DOI
  10.1038/s41598-019-56388-w
- NAID
  120006875660
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06785, KAKENHI-PROJECT-19K10533
[Journal Article] Oral anticoagulants usage in Japanese patients aged 18ー74 years with non-valvular atrial fibrillation: a retrospective analysis based on insurance claims data2019
- Author(s)
  Ohshima Ayako、Koyama Toshihiro、Ogawa Aiko、Zamami Yoshito、Tanaka Hiroyoshi Y、Kitamura Yoshihisa、Sendo Toshiaki、Hinotsu Shiro、Miller Michael W、Kano Mitsunobu R
- Journal Title
  
  Family Practice
  
  Volume: in press Issue: 6 Pages: 685-692
- DOI
  10.1093/fampra/cmz016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18944, KAKENHI-PROJECT-18K06785, KAKENHI-PROJECT-19K10533
[Journal Article] Fall-related mortality trends in older Japanese adults aged ?65 years: a nationwide observational study2019
- Author(s)
  Hagiya Hideharu、Koyama Toshihiro、Zamami Yoshito、Tatebe Yasuhisa、Funahashi Tomoko、Shinomiya Kazuaki、Kitamura Yoshihisa、Hinotsu Shiro、Sendo Toshiaki、Rakugi Hiromi、Kano Mitsunobu R
- Journal Title
  
  BMJ Open
  
  Volume: 9 Issue: 12 Pages: e033462-e033462
- DOI
  10.1136/bmjopen-2019-033462
- NAID
  120006816628
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06785, KAKENHI-PROJECT-19K10533
[Journal Article] Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness2019
- Author(s)
  Tanaka Hiroyoshi Y.、Kitahara Kentaro、Sasaki Naoki、Nakao Natsumi、Sato Kae、Narita Hirokazu、Shimoda Hiroshi、Matsusaki Michiya、Nishihara Hiroshi、Masamune Atsushi、Kano Mitsunobu R.
- Journal Title
  
  Biomaterials
  
  Volume: 192 Pages: 355-367
- DOI
  10.1016/j.biomaterials.2018.11.023
- NAID
  120006900803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02099, KAKENHI-PROJECT-18H02797
[Journal Article] Stromal barriers to nanomedicine penetration in the pancreatic tumor microenvironment2018
- Author(s)
  Tanaka Hiroyoshi Y.、Kano Mitsunobu R.
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 7 Pages: 2085-2092
- DOI
  10.1111/cas.13630
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02797
[Journal Article] In vitro 3D blood/lymph-vascularized human stromal tissues for preclinical assays of cancer metastasis2018
- Author(s)
  Nishiguchi Akihiro、Matsusaki Michiya、Kano Mitsunobu R.、Nishihara Hiroshi、Okano Daisuke、Asano Yoshiya、Shimoda Hiroshi、Kishimoto Satoko、Iwai Soichi、Akashi Mitsuru
- Journal Title
  
  Biomaterials
  
  Volume: 179 Pages: 144-155
- DOI
  10.1016/j.biomaterials.2018.06.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H00864, KAKENHI-PROJECT-17H02099, KAKENHI-PROJECT-18H02797, KAKENHI-PROJECT-17K08506
[Journal Article] Regulation of endothelial Fas expression as a mechanism of promotion of vascular integrity by mural cells in tumors.2017
- Author(s)
  Kamei R, Tanaka HY, Kawano T, Morii C, Tanaka S, Nishihara H, Iwata C, Kano MR.
- Journal Title
  
  Cancer Sci.
  
  Volume: 印刷中 Issue: 5 Pages: 1080-1088
- DOI
  10.1111/cas.13216
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293119
[Journal Article] Nanotechnologyを応用したDrug Delivery System2017
- Author(s)
  田中啓祥、狩野光伸
- Journal Title
  
  肝胆膵
  
  Volume: 75 Pages: 805-809
- Data Source
  KAKENHI-PROJECT-26293119
[Journal Article] Desmoplastic Reaction in 3D-Pancreatic Cancer Tissues Suppresses Molecular Permeability2017
- Author(s)
  Matsusaki Michiya、Komeda Misaki、Mura Simona、Tanaka Hiroyoshi Y.、Kano Mitsunobu R.、Couvreur Patrick、Akashi Mitsuru
- Journal Title
  
  Advanced Healthcare Materials
  
  Volume: 6 Issue: 15 Pages: 1700057-1700057
- DOI
  10.1002/adhm.201700057
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293119, KAKENHI-PROJECT-17H02099
[Journal Article] Desmoplastic Reaction in 3D-Pancreatic Cancer Tissues Suppresses Molecular Permeability2017
- Author(s)
  Michiya Matsusaki, Misaki Komeda, Simona Mura, Hiroyoshi Tanaka, Mitsunobu R. Kano, Patrick Couvreur, and Mitsuru Akashi
- Journal Title
  
  Adv. Healthcare Mater.
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26282138
[Journal Article] Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery2016
- Author(s)
  Yu Matsumoto, Joseph W. Nichols, Kazuko Toh, Takahiro Nomoto, Horacio Cabral, Yutaka Miura, R. James Christie, Naoki Yamada, Tadayoshi Ogura, Mitsunobu R. Kano, Yasuhiro Matsumura, Nobuhiro Nishiyama, Tatsuya Yamasoba, You Han Bae, Kazunori Kataoka
- Journal Title
  
  Nature Nanotechnology
  
  Volume: - Issue: 6 Pages: 533-538
- DOI
  10.1038/nnano.2015.342
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12534, KAKENHI-PROJECT-26670738, KAKENHI-PROJECT-26293119, KAKENHI-PROJECT-16H03179, KAKENHI-PROJECT-16K11226
[Journal Article] Increased fibrosis and impaired intratumoral accumulation of macromolecules in a murine model of pancreatic cancer co-administered with FGF-2.2016
- Author(s)
  Sakai, S., Iwata, C., Tanaka, H.Y., Cabral, H., Morishita, Y., Miyazono, K., Kano, M.R.
- Journal Title
  
  J. Control. Release
  
  Volume: 230 Pages: 109-115
- DOI
  10.1016/j.jconrel.2016.04.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293119
[Journal Article] Transplantation of three-dimensional artificial human vascular tissues fabricated using an extracellular matrix nanofilm-based cell-accumulation technique2015
- Author(s)
  Asano Y, Shimoda H, Okano D, Matsusaki M, Akashi M
- Journal Title
  
  J Tissue Eng Regen Med
  
  Volume: in press Issue: 4 Pages: 1303-1307
- DOI
  10.1002/term.2108
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460264, KAKENHI-PUBLICLY-26106717, KAKENHI-PROJECT-26282138
[Journal Article] Ultrastructure of blood and lympllatic vascular networks in three-dimensional cultured tissues fabricated by extracellular matrix nanofilm-based cell accumulation technique Microscopy2014
- Author(s)
  Yoshiya Asano, Akihiro Nishiguchi, Michiya Matsusaki, Daisuke Okano, Erina Saito, Miitsuru Akashi, Hiroshi Shimoda
- Journal Title
  
  Microscopy
  
  Volume: (In press) Issue: 3 Pages: 219-226
- DOI
  10.1093/jmicro/dfu005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J00622, KAKENHI-PROJECT-26282138
[Journal Article] Nano-pathophysiology: a novel integrated approach to disease through application of nanotechnology.2014
- Author(s)
  Kano MR.
- Journal Title
  
  Adv Drug Deliv Rev.
  
  Volume: 74 Pages: 1-1
- DOI
  10.1016/j.addr.2014.07.014
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293119
[Journal Article] 疾患難治化の原因病巣の組織構造による薬剤送達不足2014
- Author(s)
  狩野光伸
- Journal Title
  
  Drug Delivery System
  
  Volume: 29 Pages: 447-454
- Data Source
  KAKENHI-PROJECT-26293119
[Journal Article] Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation2014
- Author(s)
  H. Wu, H. Cabral, K. Toh, P. Mi, Y.-C. Chen, Y. Matsumoto, N. Yamada, X. Liu, H. Kinoh, Y. Miura, M. R. Kano, H. Nishihara, N. Nishiyama, K. Kataoka
- Journal Title
  
  J. Control. Release
  
  Volume: 189 Pages: 1-10
- DOI
  10.1016/j.jconrel.2014.06.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13F03042, KAKENHI-PROJECT-23390009, KAKENHI-PROJECT-24659584, KAKENHI-PROJECT-24689051, KAKENHI-PROJECT-25670010, KAKENHI-PROJECT-25750172, KAKENHI-PROJECT-26293119, KAKENHI-PROJECT-26670738
[Journal Article] Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors2014
- Author(s)
  Z. Ge, Q. Chen, K. Osada, X. Liu, T. A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, Y. Matsumoto, M. Oba, M. R. Kano, K. Itaka, K. Kataoka
- Journal Title
  
  Biomaterials
  
  Volume: 35 Issue: 10 Pages: 3416-3426
- DOI
  10.1016/j.biomaterials.2013.12.086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790043, KAKENHI-PROJECT-23790433, KAKENHI-PROJECT-24300170, KAKENHI-PROJECT-24790530, KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-25882011, KAKENHI-PROJECT-26293119, KAKENHI-PROJECT-26670738
[Journal Article] Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis2013
- Author(s)
  H. Cabral, N. Nishiyama, et al.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA.
  
  Volume: 110 Issue: 28 Pages: 11397-11402
- DOI
  10.1073/pnas.1301348110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13F03042, KAKENHI-PROJECT-23390009, KAKENHI-PROJECT-23790433, KAKENHI-PROJECT-25670010
[Journal Article] Nanotechnology and tumor microcirculation.2013
- Author(s)
  Kano MR.
- Journal Title
  
  Adv Drug Deliv Rev.
  
  Volume: 印刷中 Pages: 2-11
- DOI
  10.1016/j.addr.2013.08.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790433, KAKENHI-PROJECT-26293119
[Journal Article] Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis2012
- Author(s)
  M. Rafi
- Journal Title
  
  J. Control. Release
  
  Volume: 159 Issue: 2 Pages: 189-196
- DOI
  10.1016/j.jconrel.2012.01.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390009, KAKENHI-PROJECT-23700526, KAKENHI-PROJECT-23790433
[Journal Article] Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic antiangiogenic gene therapy for fibrotic pancreatic tumors2012
- Author(s)
  Q.Chen, K.Osada, T.Ishii, M.Oba, S.Uchida, T.A.Tockary, T.Endo, Z.Ge, H.Kinoh, M.R.Kano, K.Itaka, K.Kataoka
- Journal Title
  
  Biomaterials
  
  Volume: (in press) Issue: 18 Pages: 4722-4730
- DOI
  10.1016/j.biomaterials.2012.03.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10F00337, KAKENHI-PROJECT-22750098, KAKENHI-PROJECT-23350049, KAKENHI-PROJECT-23790433
[Journal Article] NC-6301, a polymeric micelle rationally optimized for effective release of docetaxel, is potent but is less toxic than native docetaxel in vivo2012
- Author(s)
  Harada M, Iwata C, Saito H, Ishii K, Hayashi T, Yashiro M,, Hirakawa K, Miyazono K, Kato Y, Kano MR
- Journal Title
  
  Int J Nanomedicine
  
  Volume: 7 Pages: 2713-27
- DOI
  10.2147/ijn.s31247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390329, KAKENHI-PROJECT-23790433
[Journal Article] Pericyte-coverage of human tumor vasculature and nanoparticle permeability.2012
- Author(s)
  Zhang L, Nishihara H, Kano MR.
- Journal Title
  
  Biol Pharm Bull.
  
  Volume: 35 Pages: 761-766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790433
[Journal Article] Pericyte-coverage of human tumor vasculature and nanoparticle permeability2012
- Author(s)
  Liuzhe Zhang, Hiroshi Nishihara, Mitsunobu R Kano
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: （印刷中）掲載確定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790433
[Journal Article] Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-b receptor inhibitor on extravasation of nanoparticles from neovasculature.2009
- Author(s)
  Kano, M.R., Komuta, Y., Iwata, C., Oka, M., Shirai, Y., Morishita, Y., Ouchi, Y., Kataoka, K., Miyazono, K.
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 173-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-βreceptor inhibitor on extravasation of nanoparticles from neovasculature.2009
- Author(s)
  Kano, M.R., Komuta, Y., Iwata, C., Oka, M., Shirai, Y., Morishita, Y., Ouchi, Y., Kataoka, K., Miyazono, K.
- Journal Title
  
  Cancer Sci. 100(1)
  
  Pages: 173-180
- NAID
  10025141855
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] Pin1 down-regulates transforming growth factor-β(TGF-β) signaling by inducing degradation of Smad proteins2009
- Author(s)
  Nakano, A., et al.
- Journal Title
  
  J Biol Chem. 284
  
  Pages: 6109-6115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-β receptor inhibitor on extravasation of nanoparticles from neovasculature2009
- Author(s)
  Kano, M.R., et al.
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 173-180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] Autophagy is activated by TGF-βand potentiates TGF- β-mediated growth inhibition in human hepatocellular carcinoma cells.2009
- Author(s)
  Kiyono, K., Suzuki, H.I., Matsuyama, H., Morishita, Y., Komuro, A., Kano, M.R., Sugimoto, K., Miyazono, K.
- Journal Title
  
  Cancer Res. 69(23)
  
  Pages: 8844-8852
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] EMT制御と分子標的薬2009
- Author(s)
  狩野光伸・宮園浩平
- Journal Title
  
  実験医学 27
  
  Pages: 653-660
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-βsignaling in diffuse-type gastric carcinoma.2009
- Author(s)
  Kiyono, K., Suzuki, H.I., Morishita, Y., Komuro, A., Iwata, C., Yashiro, M., Hirakawa, K., Kano, M.R., Miyazono, K.
- Journal Title
  
  Cancer Sci. 100(10)
  
  Pages: 1809-1816
- NAID
  10027195355
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-b receptor inhibitor on extravasation of nanoparticles from neovasculature2009
- Author(s)
  Kano, M.R., Komuta, Y., Iwata, C., Oka, M., Shirai, Y., Morishit a, Y., Ouchi, Y., Kataoka, K., and Miyazono, K.
- Journal Title
  
  Cancer Sci 100
  
  Pages: 173-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] Diffuse-type gastric carcinoma: Progression, angiogenesis, and transforming growth factor-βsignaling.2009
- Author(s)
  Komuro, A., Yashiro, M., Iwata, C., Morishita, Y., Johansson, E., Matsumoto, Y., Watanabe, A., Aburatani, H., Miyoshi, H., Kiyono, K., Shirai, Y., Suzuki, H.I., Hirakawa, K., Kano, M.R., Miyazono, K.
- Journal Title
  
  J. Natl. Cancer Inst. 101(8)
  
  Pages: 592-604
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] EMT制御と分子標的薬2009
- Author(s)
  狩野光伸, 宮園浩平
- Journal Title
  
  実験医 27
  
  Pages: 653-660
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] Role of Ras signaling in the induction of snail by transforming growth factor-β.2009
- Author(s)
  Horiguchi, K., Shirakihara, T., Nakano, A., Imamura, T., Miyazono, K., Saitoh, M.
- Journal Title
  
  J. Biol. Chem. 284(1)
  
  Pages: 245-253
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] 腫瘍発育、血管新生、治療反応性への動脈硬化と血管老化の影響2008
- Author(s)
  狩野光伸
- Journal Title
  
  分子細胞治療 7(1)
  
  Pages: 79-80
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] Inhibition of endogenous TGF-βsignaling enhances lymphangiogenesis.2008
- Author(s)
  Oka, M., Iwata, C., Suzuki, H.I., Kiyono, K., Morishita, Y., Watabe, T., Komuro, A., Kano, M.R., Miyazono, K.
- Journal Title
  
  Blood 111(9)
  
  Pages: 4571-4579
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] Inhibition of endogenous TGF-b signaling enhances lymphangiogenesis2008
- Author(s)
  Oka, M., Iwata, C., Suzuki, H.I., Kiyono, K., Morishita, Y., Watabe, T., Komuro, A., Kano, M.R., Miyazono, K.
- Journal Title
  
  Blood 111
  
  Pages: 4571-4579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] 血管におけるTGF-βファミリーシグナル2008
- Author(s)
  狩野光伸・宮園浩平
- Journal Title
  
  医学のあゆみ 223
  
  Pages: 1037-1042
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] Polyplex Micelles from Triblock Copolymers Composed of Tandemly Alirned Segments with Biocompatible, Endosomal Escaping, and DNA-Contdeasing Functions for Systemic Gene Delivery to Pancreatic Tumor Tissue2008
- Author(s)
  Miyata K, Oba M, Kano MR, F ukushima S, Vachutinsky Y, Han M, Koyama H, Miyazono K, Nishivama N. Kataoka K.
- Journal Title
  
  Pharm Res 25
  
  Pages: 924-936
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] Inhibition of endogenous TGF-b signaling enhances lymphangiogenesis2008
- Author(s)
  Oka, M., Iwata, C., Suzuki, H.I. , Kiyono, K., Morishita, Y., Watabe, T., Komuro, A., Kano, M.R., and Miyazono, K.
- Journal Title
  
  Blood 111
  
  Pages: 4571-4579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] Polyplex Micelles from Triblock Copolymers Composed of Tandemly Aligned Segments with Biocompatible, Endosomal Escaping, and DNA-Condensing Functions for Systemic Gene Delivery to Pancreatic Tumor Tissue.2008
- Author(s)
  Miyata K, Oba M, Kano MR, Fukushima S, Vachutinsky Y, Han M, Koyama H, Miyazono K, Nishiyama N, Kataoka K.
- Journal Title
  
  Pharm Res. 25
  
  Pages: 924-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] Improvement of cancer-targeting therapy using nanocarriers for intractable solid tumors by inhibition of TGF-βsignalling. Proc.2007
- Author(s)
  Kano, M.R., Bae, Y., Iwata, C., Morishita, Y., Yashiro, M., Oka, M., Fujii, T., Komuro, A., Kiyono, K., Kaminishi, M., Hirakawa, K., Ouchi, Y., Nishiyama, N., Kataoka, K., Miyazono, K.
- Journal Title
  
  Natl. Acad. Sci. USA 104(9)
  
  Pages: 3460-3465
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] TGF-βシグナルの制御と癌治療2007
- Author(s)
  狩野光伸
- Journal Title
  
  細胞 39(8)
  
  Pages: 31-33
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] Improvement of cancer-targeting therapy using nanocarriers for intractable solid tumors by inhibition of TGF-β signalling.2007
- Author(s)
  Kano, M.R., et al.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 104 (9)
  
  Pages: 3460-3465
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] Inhibition of Cyclooxygenase-2 (COX-2) Suppresses Lymph Node Metastasis via Reduction of Lymphangiogenesis.2007
- Author(s)
  C. Iwata, M. R. Kano, A. Komuro, M. Oka, K. Kiyono, E. Johansson, Y. Morishita, M. Kaminishi, M. Yashiro, K. Hirakawa, K. Miyazono
- Journal Title
  
  Cancer Res. 67 (21)
  
  Pages: 10181-10189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] ナノ粒子抗癌剤と低用量TGF-β阻害剤の併用による難治癌治療2007
- Author(s)
  狩野光伸
- Journal Title
  
  実験医学 25(9)
  
  Pages: 1344-1347
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] 血管におけるTGF-βファミリーシグナル2007
- Author(s)
  狩野光伸・宮園浩平
- Journal Title
  
  医学のあゆみ 223(12)
  
  Pages: 1037-1042
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling2007
- Author(s)
  M. R. Kano, Y. Bae, C. Iwata, Y. Morishita, M. Yashiro, M. Oka, T. Fujii, A. Komuro, K. Kiyono, M. Kaminishi, K. Hirakawa, Y. Ouchi, N. Nishiyama, K. Kataoka, and K. Miyazono
- Journal Title
  
  Proc, Natl. Acad. Sci. U.S.A. 104(9)
  
  Pages: 3460-3465
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling.2007
- Author(s)
  M. R. Kano, Y. Bae, C. Iwata, Y. Morishita, M. Yashiro, M. Oka, T. Fujii, A. Komuro, K. Kiyono, M. Kaminishi, K. Hirakawa, Y. Ouchi, N. Nishiyama, K. Kataoka, K. Miyazono
- Journal Title
  
  Proc. Natl. Acad. Sci. U.S.A. 104(9)
  
  Pages: 3460-3465
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] Inhibition of Cyclooxygenase-2(COX-2)Suppresses Lymph Node Metastasis via Reduction of Lymphangiogenesis2007
- Author(s)
  C. Iwata, M. R. Kano, A. Komuro, M. Oka, K. Kiyono, E. Johansson, Y. Morishita, M. Kaminishi, M. Yas hiro, K. Hirakawa, and K. Miyazono
- Journal Title
  
  Cancer Res. 67(21)
  
  Pages: 10181-10189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] 血管におけるTGF-βファミリーシグナル2007
- Author(s)
  狩野光伸, 宮園浩平
- Journal Title
  
  医学のあゆみ 223(12)
  
  Pages: 1037-1042
- Data Source
  KAKENHI-PROJECT-19790282
[Journal Article] VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B/PDGFRβ signaling2005
- Author(s)
  Kano, M.R., et al.
- Journal Title
  
  J.Cell Sci. 118・16
  
  Pages: 3759-3768
- Data Source
  KAKENHI-PROJECT-17016011
[Journal Article] VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B/PDGFRβsignaling.2005
- Author(s)
  Kano, M.R., Morishita, Y., Iwata, C., Iwasaka, S., Watabe, T., Ouchi, Y., Miyazono, K., Miyazawa, K.
- Journal Title
  
  J. Cell Sci. 118(16)
  
  Pages: 3759-3768
- Data Source
  KAKENHI-PROJECT-17016011
[Patent] モデル血管システム、シアストレス負荷用のモデル血管部及び循環器系疾患の治療薬のスクリーニング方法2017
- Inventor(s)
  狩野光伸、松崎愛子、田中啓祥
- Industrial Property Rights Holder
  狩野光伸、松崎愛子、田中啓祥
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-017692
- Filing Date
  2017-02-02
- Data Source
  KAKENHI-PROJECT-26293119
[Patent] 特許出願2016
- Inventor(s)
  岡山大学狩野光伸
- Industrial Property Rights Holder
  岡山大学狩野光伸
- Industrial Property Rights Type
  特許
- Filing Date
  2016-03-30
- Data Source
  KAKENHI-PROJECT-26293119
[Patent] 腫瘍撮像用MRI造影剤2007
- Inventor(s)
  片岡一則、熊谷康顕、狩野光伸、関野正樹、松浦哲也、西山伸宏、宮園浩平
- Industrial Property Rights Holder
  東京大学TLO
- Industrial Property Number
  2007-124908
- Filing Date
  2007-06-25
- Data Source
  KAKENHI-PROJECT-19790282
[Patent] TGF-βシグナル阻害剤と抗腫瘍剤の組合せ使用2006
- Inventor(s)
  宮園浩平、片岡一則、狩野光伸、べーユンスー、西山伸宏、平川弘聖、八代正和、野出學
- Industrial Property Rights Holder
  東京大学
- Acquisition Date
  2006-02-01
- Data Source
  KAKENHI-PROJECT-17016011
[Presentation] 膵がん線維化障壁をTRPP3阻害により克服するナノ薬剤送達戦略の開発2023
- Author(s)
  中澤拓也、田中啓祥、狩野光伸
- Organizer
  第39回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27344
[Presentation] Why Pancreatic Cancer is so Difficult to Treat: the presence of stroma and the use of nanoparticles2023
- Author(s)
  Mitsunobu Kano
- Organizer
  The Third International Conference of The Faculty of Pharmacy, Ain Shams University “Sustainability and Innovation in Pharmaceutical Research and Industry”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27344
[Presentation] がん微小環境とイメージング2022
- Author(s)
  田中啓祥、狩野光伸
- Organizer
  MRIコラボ・ワークショップ2022
- Invited
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] 三次元培養法による膵がん線維化組織のモデル化および筋線維芽細胞分化機序の解析2022
- Author(s)
  中澤拓也、田中啓祥、狩野光伸
- Organizer
  日本薬学会第142回年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] 線維化量を制御可能なヒト膵がん微小環境の三次元培養モデルの確立・解析とナノDDS研究への応用2021
- Author(s)
  田中啓祥、狩野光伸
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] Heterotypic 3D Cell Culture Model Of The Pancreatic Cancer Tumor Microenvironment With A Tunable Proportion Of Fibrotic Elements2021
- Author(s)
  Hiroyoshi Y. Tanaka, Mitsunobu R. Kano
- Organizer
  EACR Goodbye Flat Biology: Next Generation Cancer Models
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] Heterotypic 3D Culture Model of the Pancreatic Cancer Microenvironment with a Tunable Proportion of Fibrotic Elements2020
- Author(s)
  田中啓祥，正宗淳，狩野光伸
- Organizer
  第79回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] Why pancreatic cancer is difficult to treat: analyzing the characteristics of the disease tissue2020
- Author(s)
  Mitsunobu R Kano
- Organizer
  4th International Pharma Conference "Global Challenges and Pharmaceutical Impacts"
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] 立体培養法による組織微小環境モデルの開発および疾患研究への応用2020
- Author(s)
  田中啓祥、狩野光伸
- Organizer
  日本化学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08128
[Presentation] 膵臓がん線維化組織の3D培養モデルを利用したナノ薬剤送達効率の解析2020
- Author(s)
  田中啓祥，狩野光伸
- Organizer
  第36回日本DDS学会
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] Scientific thinking and the real world-thoughts from medicine and SDGs2020
- Author(s)
  Mitsunobu R Kano
- Organizer
  Challenges facing humanity at the age of COVID-19 and beyond: Women in Science Without Borders
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] 日本語)日本における副作用に起因した死亡率の傾向に関する全国規模の観察研究2020
- Author(s)
  舩橋智子、小山敏広、狩野光伸
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-19K10533
[Presentation] 大学はSDGs達成にどのようにかかわれるか2019
- Author(s)
  狩野光伸
- Organizer
  第71回生物工学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] Thoughts on STI to achieve the SDGs2019
- Author(s)
  Mitsunobu R Kano
- Organizer
  Tsukuba Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] 世界と地域に新たな価値を創造しつづけるSDGs推進研究大学2019
- Author(s)
  狩野光伸
- Organizer
  日経SDGsフォーラム　特別シンポジウム社会的共通資本としての医療
- Invited
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] Thoughts on the use of Information Science: Importance of QUESTIONS2019
- Author(s)
  Mitsunobu R Kano
- Organizer
  "lndia-Japan Collaborative Workshop on Health Research" jointly organized by AMED and ICMR-DST
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] 立体培養法による組織微小環境モデルの開発および疾患研究への応用2019
- Author(s)
  田中啓祥, 狩野光伸
- Organizer
  日本化学会第100春季年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] 難治の病気に科学技術で立ち向かうには2019
- Author(s)
  狩野光伸
- Organizer
  外務省科学技術外交セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] 膵臓がんにおいてナノ薬剤送達の障壁となる線維化組織の立体培養法によるモデル化および解析2019
- Author(s)
  田中啓祥, 狩野光伸
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] Pancreatic stellate cells from human pancreatic cancer show aberrant ECM remodeling in 3D engineered fibrotic tissue2019
- Author(s)
  田中啓祥, 狩野光伸
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] Answering questions from the real world -from medicine to the SDGs-2019
- Author(s)
  Mitsunobu R Kano
- Organizer
  3rd International Conference of Women in Science without Borders (WISWB), Cairo, Egypt
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] 膵がんにおける組織構築の特徴とナノ薬剤の活用法を考える2018
- Author(s)
  狩野光伸・田中啓祥
- Organizer
  日本DDS学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02797
[Presentation] Developing experimental models to analyze the behavior of Nano-DDSs within biological systems2017
- Author(s)
  Kano MR, Tanaka HY
- Organizer
  日本癌学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293119
[Presentation] Thoughts on meaning of the "academy" activity2017
- Author(s)
  Mitsunobu R Kano
- Organizer
  Y-KAST - YAJ Bilateral Workshop
- Place of Presentation
  韓国ソウル
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293119
[Presentation] インフラストラクチャーの重要性2016
- Author(s)
  狩野光伸
- Organizer
  第二回血管生物若手研究会
- Place of Presentation
  仙台
- Year and Date
  2016-03-04
- Invited
- Data Source
  KAKENHI-PROJECT-26293119
[Presentation] 医療ビッグデータに基づく直接作用型経口抗凝固薬のワルファリンに対する有効性・安全性評価に関する臨床疫学研究2016
- Author(s)
  大島礼子、小山敏広、小川愛子、座間味義人、樋之津史郎、狩野光伸
- Organizer
  日本薬学会中四国支部学術大会
- Place of Presentation
  岡山市
- Data Source
  KAKENHI-PROJECT-16K08910
[Presentation] オルガノイドの創薬研究への応用2016
- Author(s)
  狩野　光伸
- Organizer
  日本バイオマテリアル学会シンポジウム2016
- Place of Presentation
  福岡
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293119
[Presentation] ナノ病態生理学：ナノ視点から見た腫瘍血管と間質2015
- Author(s)
  狩野光伸
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-29
- Invited
- Data Source
  KAKENHI-PROJECT-26293119
[Presentation] ナノメディシン活用の方途を広げる：ナノ病態生理学の可能性2015
- Author(s)
  狩野光伸
- Organizer
  第1回徳島ナノメディシン・シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2015-07-29
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293119
[Presentation] ナノ薬剤にとっての腫瘍到達への関門2015
- Author(s)
  狩野光伸
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-26293119
[Presentation] ナノDDSと難治がんの微小環境：ナノ病態生理学2015
- Author(s)
  狩野光伸
- Organizer
  第37回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2015-11-20
- Invited
- Data Source
  KAKENHI-PROJECT-26293119
[Presentation] Unexpectedness and long-term goals.2015
- Author(s)
  Kano, MR
- Organizer
  China-Japan S&T collaboration toward future smart society, China-Japan Interdisciplinary Science and Technology Innovation Salon 2015
- Place of Presentation
  北京
- Year and Date
  2015-11-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293119
[Presentation] 疾患難治化の原因：病巣の組織構造による薬剤送達不足2014
- Author(s)
  狩野光伸
- Organizer
  第30回日本DDS学会
- Place of Presentation
  東京
- Year and Date
  2014-07-31
- Invited
- Data Source
  KAKENHI-PROJECT-26293119
[Presentation] がんの組織構造理解と製剤技術ー違いを橋渡して難局を克服する試みー2014
- Author(s)
  狩野光伸
- Organizer
  第51回薬剤学懇談会
- Place of Presentation
  沖縄
- Year and Date
  2014-06-20
- Invited
- Data Source
  KAKENHI-PROJECT-26293119
[Presentation] ナノテクノロジーが拓く新しい医生物学2014
- Author(s)
  狩野光伸
- Organizer
  JST-CRDSナノテクノロジー・材料分野俯瞰ワークショップ
- Place of Presentation
  東京
- Year and Date
  2014-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-26293119
[Presentation] ヒトの正常・異常部位における薬剤の挙動はどのようにモデル化できるか：ナノ薬剤を用いた知見からの考察2014
- Author(s)
  狩野光伸
- Organizer
  安全性評価研究会
- Place of Presentation
  長野
- Year and Date
  2014-09-05
- Invited
- Data Source
  KAKENHI-PROJECT-26293119
[Presentation] Use of nanoparticle to analyze vasculature in diseases2013
- Author(s)
  狩野　光伸
- Organizer
  第90会日本生理学会大会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23790433
[Presentation] Use of nanoparticle to analyze vasculature in diseases2013
- Author(s)
  Kano MR
- Organizer
  The 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’13)
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-23790433
[Presentation] Use of nanoparticle to analyze vasculature in diseases2013
- Author(s)
  Kano MR
- Organizer
  国際膵臓フォーラム
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-23790433
[Presentation] Use of nanoparticle to analyze vasculature in diseases2012
- Author(s)
  Mitsunobu Kano
- Organizer
  IEEE nanomed 2012
- Place of Presentation
  タイ王国バンコク
- Invited
- Data Source
  KAKENHI-PROJECT-23790433
[Presentation] Clinicopathological analysis for glioma-specific vascular structures2009
- Author(s)
  Nishihara, H., Kano, M.R., et al.
- Organizer
  AACR Special Conference, Genetics and Biology of Brain Cancers
- Place of Presentation
  Omni San Diego Hotel San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-17016011
[Presentation] Optimal choice of kinase inhibitors for manipulation of tumor vasculature : depending on the original degree of pericyte coverage2009
- Author(s)
  Kano, M.R., et al.
- Organizer
  AACR 100th Annual Meeting 2009
- Place of Presentation
  Colorado Convention Center, Denver, USA
- Data Source
  KAKENHI-PROJECT-17016011
[Presentation] 脈管制御を応用した難治がん治療法の開拓2009
- Author(s)
  狩野光伸
- Organizer
  第7回次世代バイオマテリアル研究会
- Place of Presentation
  東京都文京区1東京医科歯科大学生体材料工学研究所
- Year and Date
  2009-03-09
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] Animal models for functional analysis of tumor vasculature2009
- Author(s)
  Kano, M.R., et al.
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜パシフィコ・横浜
- Data Source
  KAKENHI-PROJECT-17016011
[Presentation] 脈管制御を応用した難治がん治療法の開拓2009
- Author(s)
  狩野光伸
- Organizer
  第7回次世代バイオマテリアル研究会
- Place of Presentation
  東京医科歯科大学
- Year and Date
  2009-03-09
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] 腫瘍血管新生制御が薬剤送達に影響を与える際の組織学的要因の解明2008
- Author(s)
  狩野光伸
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  石川県立音楽堂
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] Optimal manipulation of tumor vasculature for treatment of intractable solid tumors using nanoparticles2008
- Author(s)
  狩野光伸
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  愛知県名古屋市名古屋国際会議場
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] 難治性固形腫瘍に対するナノDDS治療の実現化2008
- Author(s)
  狩野光伸
- Organizer
  第24回日本DDS学会学術総会
- Place of Presentation
  東京都港区六本木アカデミーヒルズ
- Year and Date
  2008-06-30
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] Optimal manipulation of tumor vasculature for treatment of intractable solid tumors using nanoparticles2008
- Author(s)
  Kano, MR.
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋市(名古屋国際会議場)
- Data Source
  KAKENHI-PROJECT-17016011
[Presentation] 腫瘍血管新生制御が薬剤送達に影響を与える際の組織学的要因の解明2008
- Author(s)
  狩野光伸
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  石川県金沢市石川県立音楽堂
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] Manipulation of TGF-β signaling for cancer treatment.2008
- Author(s)
  Kano, MR.
- Organizer
  28th Sapporo Cancer Seminar International Symposium.
- Place of Presentation
  北海道大学
- Year and Date
  2008-06-27
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] 難治性固形腫瘍に対するナノDDS治療の実現化2008
- Author(s)
  狩野光伸
- Organizer
  第24回日本DDS 学会学術総会
- Place of Presentation
  六本木ヒルズ
- Year and Date
  2008-06-30
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] Optimal manipulation of tumor vasculature for treatment of intractable solid tumors using nanoparticles.2008
- Author(s)
  Kano, MR.
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] Manipulation of TGF-β signaling for cancer treatment2008
- Author(s)
  狩野光伸
- Organizer
  28th Sapporo Cancer Seminar International Symposium ; Sapporo, Janan
- Place of Presentation
  北海道札幌市北海道大学学術交流会館
- Year and Date
  2008-06-27
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] Low-dose TGF-beta inhibitor improves cancer therapy using nanocarriers for intractable solid tumors2007
- Author(s)
  Kano, MR, Bae, YS., Iwata, C., Oka, M., Fujii, T., Morishita, Y., Nishiyama, N., Kataoka, K., Miyazono, K
- Organizer
  The 34th Annual Meeting of the Controlled Release Society
- Place of Presentation
  Long Beach, CA, USA
- Year and Date
  2007-06-11
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] Low-dose TGF-beta inhibitor improves cancer-targeting therapy using nanocarriers for intractable solid tumors.2007
- Author(s)
  Kano, MR, Bae, YS., Iwata, C., Oka, M., Shirai, Y., Fujii, T., Morishita, Y., Nishiyama, N., Kataoka, K., Miyazono, K.
- Organizer
  Gordon Research Conference, Angiogenesis and microcirculation.
- Place of Presentation
  Salva Regina University, Newport, RI, USA
- Year and Date
  2007-08-22
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] Low-dose TGF-beta inhibitor improves cancer-targeting therapy using nanocarriers for intractable solid tumors2007
- Author(s)
  Kano, MR, Bae, YS., Iwata, C., Oka, M., Shirai, Y., Fujii, T., Morishita, Y., Nishiyama, N., Kataoka, K., Miyazono, K
- Organizer
  Gordon Research Conference, Angiogenesis and microcirculation
- Place of Presentation
  Newport, RI, USA
- Year and Date
  2007-08-22
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] Low-dose TGF-beta inhibitor improves cancer therapy using nanocarriers for intractable solid tumors.2007
- Author(s)
  Kano, MR, Bae, YS., Iwata, C., Oka, M., Fujii, T., Morishita, Y., Nishiyama, N., Kataoka, K., Miyazono, K
- Organizer
  The 34th Annual Meeting of the Controlled Release Society.
- Place of Presentation
  Long Beach, CA, USA
- Year and Date
  2007-06-11
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] TGF-beta signaling and regulation of cancer.2007
- Author(s)
  Kano, MR, Miyazono, K.
- Organizer
  Queenstown Molecular Biology 2007 satellite symposium.
- Place of Presentation
  Queenstown, New Zealand
- Year and Date
  2007-08-27
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] TGF-beta signaling and regulation of cancer.2007
- Author(s)
  Kano, MR, Miyazono, K
- Organizer
  Queenstown Molecular Biology 2007 satellite sympossum
- Place of Presentation
  Queenstown, New Zealand
- Year and Date
  2007-08-27
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] Optimal Manipulation of Vasculature for Nanoparticles in Intractable tumors.2007
- Author(s)
  Kano, MR.
- Organizer
  Swiss-Japan Symposium on Nanobio 2007.
- Place of Presentation
  東京大学武田先端知ビル
- Year and Date
  2007-10-11
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] Optimal Manipulation of Vasculature for Nanoparticles in Intractable tumors.2007
- Author(s)
  Kano, MR
- Organizer
  Swiss-Japan Symposium on Nanobio 2007
- Place of Presentation
  東京
- Year and Date
  2007-10-11
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] TGFβ阻害剤とナノキャリアの併用による難治固形がん治療2007
- Author(s)
  狩野光伸, 他.
- Organizer
  第23回日本DDS学会
- Place of Presentation
  熊本
- Year and Date
  2007-06-15
- Data Source
  KAKENHI-PROJECT-17016011
[Presentation] Low-dose TGF-β inhibitor for effective nanotechnology-based chemotherapy in intractable solid tumors2007
- Author(s)
  Kano, MR, Bae, YS., Iwata, C., Oka, M., Fujii, T., Morishita, Y., Nishiyama, N., Kataoka, K., Miyazono, K
- Organizer
  The 2007 AACR Annual Meeting
- Place of Presentation
  Los Angeles, CA, USA
- Year and Date
  2007-04-14
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] Low-dose TGF-s inhibitor for effective nanotechnology-based chemotherapy in intractable solid tumors.2007
- Author(s)
  Kano, MR, Bae, YS., Iwata, C., Oka, M., Fujii, T., Morishita, Y., Nishiyama, N., Kataoka, K., Miyazono, K.
- Organizer
  The 2007 AACR Annual Meeting
- Place of Presentation
  Los Angeles, CA, USA
- Year and Date
  2007-04-14
- Data Source
  KAKENHI-PROJECT-19790282
[Presentation] Use of nanoparticle to analyze vasculature in intractable tumors
- Author(s)
  Mitsunobu R Kano
- Organizer
  The 9th Japan-Korea Joint Symposium on Vascular Biology
- Place of Presentation
  大韓民国　釜山
- Invited
- Data Source
  KAKENHI-PROJECT-23790433

1. 正宗淳 (90312579)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. Hinotsu Shiro (80323567)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. Matsusaki Michiya (00419467)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. Yamamoto Masaya (10332735)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 江草宏 (30379078)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MIYAZONO Kohei (90209908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
7. MIYAZAWA Keiji (40209896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. IMAMURA Takeshi (70264421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. MAEDA Shingo (60353463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. WATABE Tetsuro (00334235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. SAITOH Masao (90345041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. KOINUMA Daizo (80375071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. EHATA Shogo (90506726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Matsubara Hiromi (70252955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Koyama Toshihiro (60595106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. 赤木隆美 (00527236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 井上正宏 (10342990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 西原広史 (50322805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 小川愛子 (40572748)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 萩谷英大 (30718531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 座間味義人 (70550250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
22. 木村剛 (10393216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 長田健介 (10396947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. OKANO Daisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. MATSUMOTO Yu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. GE Zhishen

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
27. 片岡一則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. CABRAL Horacio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 八代正和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 野本貴大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 田中啓祥

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
32. MI P.

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. MI Peng

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 西山伸宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
35. 下田浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 浅野義哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 明石満

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kano Mitsunobu 狩野 光伸

KANO Mitsunobu 狩野 光伸

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Overcoming fibrotic barriers to nanomedicine delivery in pancreatic cancerPrincipal Investigator

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Establishing a 3D model of fibrosis in pancreatic cancer and analysis of interaction between tumor cells and stellate cellsPrincipal Investigator

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Investigation of intractability of pancreatic cancer by using 3D culture of pancreatic stellate cellsPrincipal Investigator

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Molecular Mechanisms in extravasation of nanoDDSPrincipal Investigator

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Enhancement of nanoparticle accumulation via regulation of tumor vasculaturePrincipal Investigator

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[Book] Stromal barriers within the tumor microenvironment and obstacles to nanomedicine (Cancer Drug Delivery Systems based on the Tumor Microenvironment, Chapter 4)2019

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Kano Mitsunobu 狩野光伸

KANO Mitsunobu 狩野光伸