MISU Hirofumi 御簾博文

Researcher Number	80447680
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2014 – 2019: 金沢大学, 医学系, 准教授 2012 – 2013: 金沢大学, 医薬保健学総合研究科, 特任助教 2012: 金沢大学, 医薬保健学総合研究科, 助教 2011: 金沢大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Metabolomics Except Principal Investigator Gastroenterology
Keywords	Principal Investigator ヘパトカイン / インスリン抵抗性 / 糖代謝異常 / 転写因子 / 2型糖尿病 / 運動療法抵抗性 / 活性酸素 / 運動療法 / セレノプロテインP / 運動抵抗性 / エネルギー … More Except Principal Investigator … More 生活習慣病 / 栄養 / 肝臓 / 発現制御 / ゲノム Less

Identification of a novel transcription factor that regulates diabetes-related hepatokine.Principal Investigator
- Principal Investigator
  
  Misu Hirofumi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa University
Study of the liver as an endocrine organ
- Principal Investigator
  
  KANEKO Shuichi
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University
Investigation of exercise resistance induced by hepatokine selenoprotein PPrincipal Investigator
- Principal Investigator
  
  Misu Hirofumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa University
Screening for therapies of diabetes targeting novel hepatokine selenoprotein P that induces insulin resistancePrincipal Investigator
- Principal Investigator
  
  MISU Hirofumi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa University

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Patent Other

[Journal Article] Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity.2019
- Author(s)
  Murai K, Honda M, Shirasaki T, Shimakami T, Omura H, Misu H, Kita Y, Takeshita Y, Ishii KA, Takamura T, Urabe T, Shimizu R, Okada H, Yamashita T, Sakai Y, Kaneko S.
- Journal Title
  
  Cell Host Microbe
  
  Volume: 10;25(4) Issue: 4 Pages: 588-601
- DOI
  10.1016/j.chom.2019.02.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-18K08507, KAKENHI-PROJECT-19K08975, KAKENHI-PROJECT-18K19560, KAKENHI-PROJECT-19K17427, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16K09739, KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-17K09413
[Journal Article] p62-mediated autophagy affects nutrition-dependent insulin receptor substrate 1 dynamics in 3T3-L1 preadipocytes2019
- Author(s)
  Igawa Hirobumi、Kikuchi Akihiro、Misu Hirofumi、Ishii Kiyo-aki、Kaneko Shuichi、Takamura Toshinari
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 10 Issue: 1 Pages: 32-42
- DOI
  10.1111/jdi.12866
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09822, KAKENHI-PROJECT-18K08507, KAKENHI-PROJECT-18K19560, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-17H04199
[Journal Article] Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans2019
- Author(s)
  Mohri K, Misu H, Takayama H, Ishii KA, Kikuchi A, Lan F, Enyama Y, Takeshita Y, Saito Y, Kaneko S,Takamura T.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 3 Pages: 373-378
- DOI
  10.1248/bpb.b18-00549
- NAID
  130007607371
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-03-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09739, KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-18K08507, KAKENHI-PROJECT-18K19560, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-19K08975, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-17K09822, KAKENHI-PROJECT-17H03821
[Journal Article] Identification of hepatokines involved in pathology of type 2 diabetes and obesity2019
- Author(s)
  Misu Hirofumi
- Journal Title
  
  Endocr J
  
  Volume: 66 Issue: 8 Pages: 659-662
- DOI
  10.1507/endocrj.EJ19-0255
- NAID
  130007696454
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Data Source
  KAKENHI-PROJECT-16K09740
[Journal Article] Effects of metformin and alogliptin on body composition in people with type 2 diabetes.2018
- Author(s)
  Takeshita Y, Kita Y, Kato KI, Kanamori T, Misu H, Kaneko, Takamura T.
- Journal Title
  
  J Diabetes Investig
  
  Volume: Aug Issue: 3 Pages: 29-29
- DOI
  10.1111/jdi.12920
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09739, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-19K08975
[Journal Article] Inhibin betaE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples2018
- Author(s)
  M. Sugiyama, A. Kikuchi, H. Misu, H. Igawa, M. Ashihara, Y. Kushima, K. Honda, Y. Suzuki, Y. Kawabe, S. Kaneko and T. Takamura
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 3 Pages: e0194798-e0194798
- DOI
  10.1371/journal.pone.0194798
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-17K09822, KAKENHI-PROJECT-17H04199, KAKENHI-ORGANIZER-17H06391
[Journal Article] Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population.2018
- Author(s)
  Oo SM, Misu H, Saito Y, Tanaka M, Kato S, Kita Y, Takayama H, Takeshita Y, Kanamori T, Nagano T, Nakagen M, Urabe T, Matsuyama N, Kaneko S, Takamura T.
- Journal Title
  
  Sci Rep.
  
  Volume: 8 Issue: 1 Pages: 16727-16727
- DOI
  10.1038/s41598-018-35067-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09739, KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-18K19560, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-17H03821
[Journal Article] Comparison of Human Selenoprotein P Determinants in Serum between Our Original Methods and Commercially Available Kits2018
- Author(s)
  Saito Yoshiro、Misu Hirofumi、Takayama Hiroaki、Takashima Shin-ichiro、Usui Soichiro、Takamura Masayuki、Kaneko Shuichi、Takamura Toshinari、Noguchi Noriko
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 5 Pages: 828-832
- DOI
  10.1248/bpb.b18-00046
- NAID
  130006730702
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2018-05-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19560, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-16K09425, KAKENHI-PROJECT-17H03821
[Journal Article] Ursodeoxycholic acid potentiates dipeptidyl peptidase-4 inhibitor sitagliptin by enhancing glucagon-like peptide-1 secretion in patients with type 2 diabetes and chronic liver disease: a pilot randomized controlled and add-on study2018
- Author(s)
  K. R. Shima, T. Ota, K. I. Kato, Y. Takeshita, H. Misu, S. Kaneko and T. Takamura
- Journal Title
  
  BMJ Open Diabetes Res Care
  
  Volume: 6 Issue: 1 Pages: e000469-e000469
- DOI
  10.1136/bmjdrc-2017-000469
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-16K19533, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-16H03035
[Journal Article] Endogenous Selenoprotein P, a Liver-Derived Secretory Protein, Mediates Myocardial Ischemia/Reperfusion Injury in Mice.2018
- Author(s)
  Chikata A, Kato T, Usuda K, Fujita S, Maruyama M, Nagata Y, Sakagami S, Kanamori N, Yaegashi T, Saeki T, Kusayama T, Usui S, Furusho H, Kaneko S, Takamura M.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 19 Issue: 3 Pages: 878-878
- DOI
  10.3390/ijms19030878
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09425, KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-15K09135, KAKENHI-PROJECT-18K19560, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H04199
[Journal Article] Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models2017
- Author(s)
  Mita Yuichiro、Nakayama Kaho、Inari Shogo、Nishito Yukina、Yoshioka Yuya、Sakai Naoko、Sotani Kanade、Nagamura Takahiro、Kuzuhara Yuki、Inagaki Kumi、Iwasaki Miki、Misu Hirofumi、Ikegawa Masaya、Takamura Toshinari、Noguchi Noriko、Saito Yoshiro
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 1658-1658
- DOI
  10.1038/s41467-017-01863-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-16K18707, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-17H03821
[Journal Article] Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle.2017
- Author(s)
  H Misu, H Takayama, Y Saito, Y Mita, A Kikuchi, K Ishii, K Chikamoto, T Kanamori, N Tajima, F Lan, Y Takeshita, M Honda, M Tanaka, S Kato, N Matsuyama, Y Yoshioka, Iwayama K, Tokuyama K, Akazawa N, Maeda S, Takekoshi K, Matsugo S, Noguchi N, S Kaneko, T Takamura.
- Journal Title
  
  Nature Med
  
  Volume: 23 Issue: 4 Pages: 508-516
- DOI
  10.1038/nm.4295
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26461328, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-16K09739, KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-25292078, KAKENHI-PROJECT-17H04199
[Journal Article] The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight/obese men2017
- Author(s)
  Sargeant Jack A.、Aithal Guruprasad P.、Takamura Toshinari、Misu Hirofumi、Takayama Hiroaki、Douglas Jessica A.、Turner Mark C.、Stensel David J.、Nimmo Myra A.、Webb David R.、Yates Thomas、King James A.
- Journal Title
  
  Appl Physiol Nutr Metab
  
  Volume: 3 Issue: 5 Pages: 1-9
- DOI
  10.1139/apnm-2017-0639
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-18K19560, KAKENHI-PROJECT-17H04199
[Journal Article] Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes.2017
- Author(s)
  Tajima-Shirasaki N, Ishii KA, Takayama H, Shirasaki T, Iwama H, Chikamoto K, Saito Y, Iwasaki Y, Teraguchi A, Lan F, Kikuchi A, Takeshita Y, Murao K, Matsugo S, Kaneko S, Misu H, Takamura T.
- Journal Title
  
  J Biol Chem.
  
  Volume: 292 Issue: 26 Pages: 10791-10800
- DOI
  10.1074/jbc.m116.747006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09739, KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-16K21058, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-17H03821
[Journal Article] Fat-free mass and calf circumference as body composition indices to determine non-exercise activity thermogenesis in patients with diabetes2016
- Author(s)
  Y. Isobe, M. Sakurai, Y. Kita, Y. Takeshita, H. Misu, S. Kaneko, T. Takamura
- Journal Title
  
  J Diabetes Investig
  
  Volume: 7 Issue: 3 Pages: 352-358
- DOI
  10.1111/jdi.12421
- NAID
  120005682647
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-16K09740
[Journal Article] Development of a Sol Particle Homogeneous Immunoassay for Measuring Full-Length Selenoprotein P in Human Serum.2016
- Author(s)
  M. Tanaka, Y. Saito, H. Misu, S. Kato, Y. Kita, Y. Takeshita, T. Kanamori, T. Nagano, M. Nakagen, T. Urabe, T. Takamura, S. Kaneko, K. Takahashi and N. Matsuyama.
- Journal Title
  
  J Clin Lab Anal
  
  Volume: 30 Issue: 2 Pages: 114-122
- DOI
  10.1002/jcla.21824
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-25292078, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-16K09740
[Journal Article] Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice.2016
- Author(s)
  K Chikamoto, H Misu, H Takayama, A Kikuchi, KA Ishii, F Lan, N Takata, N Tajima-Shirasaki, Y Takeshita, H Tsugane, S Kaneko, S Matsugo, T Takamura.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 478 Issue: 3 Pages: 1310-1316
- DOI
  10.1016/j.bbrc.2016.08.117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461328, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-26461377, KAKENHI-PROJECT-16K09740
[Journal Article] Response to Importance of confounding factors in assessing fatty acid compositions in patients with non-alcoholic steatohepatitis2015
- Author(s)
  Yamada K, Mizukoshi E, Sunagozaka H, Arai K, Yamashita T, Takeshita Y, Misu H, Takamura T, Kitamura S, Zen Y, Nakanuma Y, Honda M, Kaneko S
- Journal Title
  
  Liver Int
  
  Volume: 35 Issue: 6 Pages: 1773-1773
- DOI
  10.1111/liv.12755
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378
[Journal Article] Liver steatosis is associated with insulin resistance in skeletal muscle rather than in the liver in Japanese patients with non-alcoholic fatty liver disease.2015
- Author(s)
  Kato K, Takeshita Y, Misu H, Zen Y, Kaneko S, Takamura T.
- Journal Title
  
  J Diabetes Investig.
  
  Volume: 6 Issue: 2 Pages: 158-163
- DOI
  10.1111/jdi.12271
- NAID
  120005593987
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-15K08345
[Journal Article] Renoprotective effects of atorvastatin compared with pravastatin on progression of early diabetic nephropathy2015
- Author(s)
  Takazakura A, Sakurai M, Bando Y, Misu H, Takeshita Y, Kita Y, Shimizu A, Hayakawa T, Kato K, Kaneko S, Takamura T
- Journal Title
  
  J Diabetes Investig
  
  Volume: 6 Issue: 3 Pages: 346-353
- DOI
  10.1111/jdi.12296
- NAID
  120005819637
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-26253046
[Journal Article] Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis.2015
- Author(s)
  Yamada K, Mizukoshi E, Sunagozaka H, Arai K, Yamashita T, Takeshita Y, Misu H, Takamura T, Kitamura S, Zen Y, Nakanuma Y, Honda M, Kaneko S.
- Journal Title
  
  Liver Int.
  
  Volume: 35(2) Issue: 2 Pages: 582-90
- DOI
  10.1111/liv.12685
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378
[Journal Article] Vildagliptin vs liraglutide as a second-line therapy switched from sitagliptin-based regimens in patients with type 2 diabetes: A randomized, parallel-group study.2015
- Author(s)
  Takeshita Y, Takamura T, Kita Y, Otoda T, Kato K, Wakakuri H, Yamada M, Misu H, Matsushima Y, Kaneko S
- Journal Title
  
  J Diabetes Investig
  
  Volume: 6 Issue: 2 Pages: 192-200
- DOI
  10.1111/jdi.12269
- NAID
  120005774894
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-26253046
[Journal Article] The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism : a randomised controlled trial2014
- Author(s)
  Y Takeshita, T Takamura, M Honda, Y Kita, Y Zen, KI Kato, H Misu, T Ota, M Nakamura, K Yamada, H Sunagozaka, K Arai, T Yamashita, E Mizukoshi, S Kaneko
- Journal Title
  
  Diabetologia
  
  Volume: 57(5) Issue: 5 Pages: 878-90
- DOI
  10.1007/s00125-013-3149-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-23701098, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-26670378
[Journal Article] LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance2014
- Author(s)
  Fei Lan, H Misu, K Chikamoto, H Takayam, A Kikuchi, K Mohri, N Takata, H Hayashi, N Matsuzawa-Nagata, Y Takeshita, H Noda, Y Matsumoto, T Ota, T Nagano, M Nakagen, K Miyamoto, K Takatsuki, T Seo, K Iwayama, K Tokuyama, S Matsugo, H Tang, Y Saito, S Yamagoe, S Kaneko, T Takamura
- Journal Title
  
  Diabete
  
  Volume: 63 Issue: 5 Pages: 1649-1664
- DOI
  10.2337/db13-0728
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J03079, KAKENHI-PROJECT-23590275, KAKENHI-PROJECT-23591301, KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25292078, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-26670229
[Journal Article] Metformin Suppresses Expression of the Selenoprotein P gene via an AMPK-FoxO3a Pathway in H4IIEC3 Hepatocytes2014
- Author(s)
  H Takayama, H Misu, H Iwama, K Chikamoto, Y Saito, K Murao, A Teraguchi, F Lan, A Kikuchi, R Saito, N Tajima, T Shirasaki, S Matsugo, KI Miyamoto, S Kaneko, T Takamura
- Journal Title
  
  J Biol Chem
  
  Volume: 289(1) Issue: 1 Pages: 335-45
- DOI
  10.1074/jbc.m113.479386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-23591301, KAKENHI-PROJECT-24591352, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-26461329
[Journal Article] Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells.2014
- Author(s)
  Ishikura K, Misu H, Kumazaki M, Takayama H, Matsuzawa-Nagata N, Tajima N, Chikamoto K, Lan F, Ando H, Ota T, Sakurai M, Takeshita Y, Kato K, Fujimura A, Miyamoto K, Saito Y, Kameo S, Okamoto Y, Takuwa Y, Takahashi K, Kidoya H, Takakura N, Kaneko S, Takamura T
- Journal Title
  
  Diabetologia
  
  Volume: 57 Issue: 9 Pages: 1968-1976
- DOI
  10.1007/s00125-014-3306-9
- NAID
  120005463349
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22112005, KAKENHI-PROJECT-24390051, KAKENHI-PUBLICLY-25116711, KAKENHI-PUBLICLY-25122710, KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25292078, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-25670162, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461329
[Journal Article] Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic Fatty liver disease2014
- Author(s)
  K Kato, T Takamura, Y Takeshita, Y Ryu, H Misu, T Ota, K Tokuyama, S Nagasaka, M Matsuhisa, O Matsui, S Kaneko
- Journal Title
  
  PLoS One
  
  Volume: 9(3) Issue: 3 Pages: e92170-e92170
- DOI
  10.1371/journal.pone.0092170
- NAID
  120005440398
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-23591301, KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-26461329
[Journal Article] Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver2013
- Author(s)
  T Otoda, T Takamura, H Misu, T Ota, S Murata, H Hayashi, H Takayama, A Kikuchi, T Kanamori, KR Shima, F Lan, T Takeda, S Kurita, K Ishikura, Y Kita, K Iwayama, KI Kato, M Uno, Y Takeshita, M Yamamoto, K Tokuyama, S Iseki, K Tanaka, S Kaneko
- Journal Title
  
  Diabetes
  
  Volume: 62(3) Issue: 3 Pages: 811-24
- DOI
  10.2337/db11-1652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-23591301, KAKENHI-PROJECT-23791022, KAKENHI-PROJECT-25282017
[Journal Article] Duodenal adenocarcinoma with neuroendocrine features in a patient with acromegaly and thyroid papillary adenocarcinoma: a unique combination of endocrine neoplasia.2012
- Author(s)
  Kato K, Takeshita Y, Misu H, (他5名)
- Journal Title
  
  Endocr J
  
  Volume: 59 Pages: 791-796
- NAID
  10031123122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791022
[Journal Article] Fatty liver as a consequence and cause of insulin resistance: lessons from type 2 diabetic liver.2012
- Author(s)
  Takamura T, Misu H, (他2名)
- Journal Title
  
  Endocr J.
  
  Volume: 59 Pages: 745-763
- NAID
  10031123118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791022
[Journal Article] Fatty liver as a consequence and cause of insulin resistance: lessons from type 2 diabetic liver2012
- Author(s)
  Takamura T, Misu H, (他2名)
- Journal Title
  
  Endocr J
  
  Volume: 59(9) Pages: 745-63
- NAID
  10031123118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791022
[Journal Article] Regulation of glucose metabolism by liver-derived secretory proteins 'hepatokines'2012
- Author(s)
  Misu H, (他8名)
- Journal Title
  
  Nihon Rinsho
  
  Volume: 70 Suppl 3 Pages: 207-11
- NAID
  40019323808
- Data Source
  KAKENHI-PROJECT-23791022
[Journal Article] Duodenal adenocarcinoma with neuroendocrine features in a patient with acromegaly and thyroid papillary adenocarcinoma: a unique combination of endocrine neoplasia2012
- Author(s)
  Kato K, Takeshita Y, Misu H, (他5名)
- Journal Title
  
  Endocr J
  
  Volume: 59(9) Pages: 791-6
- NAID
  10031123122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791022
[Journal Article] Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes2012
- Author(s)
  H Misu, K Ishikura, S Kurita, Y Takeshita, T Ota, Y Saito, K Takahashi, S Kaneko, T Takamura
- Journal Title
  
  PLoS One
  
  Volume: 7(4) Issue: 4 Pages: e34952-e34952
- DOI
  10.1371/journal.pone.0034952
- NAID
  120004140847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-23591301, KAKENHI-PROJECT-23791022
[Journal Article] Pharmacokinetics and pharmacodynamics of insulin aspart in patients with Type 2 diabetes : Assessment using a meal tolerance test under clinical conditions2012
- Author(s)
  H Ando, S Kurita, A Shimizu, K Kato, K Ishikura, K Taji, M Uno, Y Takeshita, H Misu, A Fujimura, S Kaneko, T Takamura
- Journal Title
  
  Clin Exp Pharmacol Physiol
  
  Volume: 39(6) Issue: 6 Pages: 528-34
- DOI
  10.1111/j.1440-1681.2012.05708.x
- NAID
  120004442389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-23791022
[Journal Article] Slowly progressive insulin-dependent diabetes in a patient with primary biliary cirrhosis with portal hypertension-type progression.2012
- Author(s)
  Takeshita Y, Takamura T, Inoue O, Okumura M, Kato K, Sunagozaka H, Arai K, Misu H, (他3名)
- Journal Title
  
  Intern Med
  
  Volume: 51 Pages: 79-82
- NAID
  130002062431
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791022
[Journal Article] Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis2012
- Author(s)
  Y Kita, T Takamura, H Misu, T Ota, S Kurita, Y Takeshita, M Uno, N Matsuzawa-Nagata, K Kato, H Ando, A Fujimura, K Hayashi, T Kimura, Y Ni, T Otoda, K Miyamoto, Y Zen, Y Nakanuma, S Kaneko
- Journal Title
  
  PLoS One
  
  Volume: 7(9) Issue: 9 Pages: e43056-e43056
- DOI
  10.1371/journal.pone.0043056
- NAID
  120004966626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-23591301, KAKENHI-PROJECT-23791022
[Journal Article] Novel strategies that target hepatokines for treatment of type 2 diabetes2012
- Author(s)
  Misu H, (他2名)
- Journal Title
  
  Nihon Rinsho
  
  Volume: 70(1) (Review) Pages: 157-63
- NAID
  40019140134
- Data Source
  KAKENHI-PROJECT-23791022
[Journal Article] Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance : Implications for type 2 diabetes. Metabolism2012
- Author(s)
  Honda M, (他12名, 12番目)
- Journal Title
  
  Epub ahead of print
  
  Volume: (Epub ahead of print) Issue: 10 Pages: 1388-94
- DOI
  10.1016/j.metabol.2012.03.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390227, KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-23590968, KAKENHI-PROJECT-23591301, KAKENHI-PROJECT-23791022, KAKENHI-PROJECT-24390187
[Journal Article] Regulation of glucose metabolism by liver-derived secretory proteins 'hepatokines'.2012
- Author(s)
  Misu H, (他8名)
- Journal Title
  
  Nihon Rinsho
  
  Volume: 70 Pages: 207-211
- NAID
  40019323808
- Data Source
  KAKENHI-PROJECT-23791022
[Journal Article] Novel strategies that target hepatokines for treatment of type 2 diabetes.2012
- Author(s)
  Misu H, (他2名)
- Journal Title
  
  Nihon Rinsho
  
  Volume: 70 Pages: 157-163
- NAID
  40019140134
- Data Source
  KAKENHI-PROJECT-23791022
[Journal Article] Slowly progressive insulin-dependent diabetes in a patient with primary biliary cirrhosis with portal hypertension-type progression2012
- Author(s)
  Takeshita Y, Takamura T, Inoue O, Okumura M, Kato K, Sunagozaka H, Arai K, Misu H, (他3 名)
- Journal Title
  
  Intern Med
  
  Volume: 51(1) Pages: 79-82
- NAID
  130002062431
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791022
[Journal Article] The cutting-edge of medicine; clinical and molecular pathology of type 2 diabetic liver2011
- Author(s)
  Takamura T, Misu H, (他1 名)
- Journal Title
  
  Nihon Naika Gakkai Zasshi
  
  Volume: 100(6) Pages: 1670-6
- Data Source
  KAKENHI-PROJECT-23791022
[Journal Article] Dose-dependent Dual Effects of Hydrogen Peroxide on Insulin Signal Transduction in H4IIEC Hepatocytes.2011
- Author(s)
  Iwakami S, Misu H, Takeda T, Sugimori M, Matsugo S, Kaneko S, Takamura T
- Journal Title
  
  PLoS ONE
  
  Volume: 6 Issue: 11 Pages: e27401-e27401
- DOI
  10.1371/journal.pone.0027401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591301, KAKENHI-PROJECT-23791022
[Patent] ２型糖尿病患者の治療薬選択の補助方法，治療薬の効果予測方法及び検査方法2015
- Inventor(s)
  御簾博文、竹下有美枝、篁　俊成、金子周一
- Industrial Property Rights Holder
  金沢大学
- Industrial Property Rights Type
  特許
- Filing Date
  2015-09-10
- Overseas
- Data Source
  KAKENHI-PROJECT-26253046
[Patent] ２型糖尿病患者の治療薬選択の補助方法，治療薬の効果予測方法及び検査方法2014
- Inventor(s)
  御簾　博文、竹下　有美枝、篁　俊成、金子　周一
- Industrial Property Rights Holder
  金沢大学
- Industrial Property Rights Type
  特許
- Filing Date
  2014-09-10
- Data Source
  KAKENHI-PROJECT-26253046
[Presentation] ヘパトカインセレノプロテインPと糖尿病全身病態との関連2019
- Author(s)
  御簾博文
- Organizer
  第33回日本糖尿病・肥満動物学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09740
[Presentation] Diabetes-associated systemic pathology induced by hepatokines2019
- Author(s)
  御簾博文，篁俊成
- Organizer
  第６２回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09740
[Presentation] Contribution of the hepatokine selenoprotein P to the various pathologies of type 2 diabetes2019
- Author(s)
  Hirofumi Misu
- Organizer
  The 9th Federation of Asian and Oceanian Physiological Societies Congress: FAOPS2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09740
[Presentation] ヘパトカインセレノプロテインPの2型糖尿病病態に対する多面的作用2018
- Author(s)
  御簾博文
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09740
[Presentation] ヘパトカインによる糖代謝維持機構とその破綻2018
- Author(s)
  御簾博文
- Organizer
  第32回日本糖尿病肥満動物学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09740
[Presentation] ヘパトカインセレノプロテインPと骨格筋受容体LRP1による”運動抵抗性”の発症2017
- Author(s)
  御簾博文
- Organizer
  第3回日本筋学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09740
[Presentation] ヘパトカインSePは筋受容体LRP1を介して運動抵抗性を惹起する2017
- Author(s)
  御簾博文,高山浩昭, 金子周一, 篁. 俊成
- Organizer
  第90回日本内分泌学会
- Data Source
  KAKENHI-PROJECT-16K09740
[Presentation] “サイレンシングヘパトカイン”セレノプロテインPの過剰による2型糖尿病関連病態の発症2017
- Author(s)
  御簾博文
- Organizer
  生命科学系学会合同年次大会ConBio2017
- Data Source
  KAKENHI-PROJECT-16K09740
[Presentation] ヘパトカインセレノプロテインPが惹起する運動療法抵抗性に関する解析2017
- Author(s)
  高山浩昭、御簾博文、菊地晶裕、石井清朗、斎藤芳郎、金子周一、篁俊成
- Organizer
  第31回日本糖尿病肥満動物学会
- Place of Presentation
  横浜
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-16K09740
[Presentation] ヘパトカインセレノプロテインPと筋受容体LRP1は活性酸素・AMPK経路の抑制によって運動抵抗性を誘導する2017
- Author(s)
  御簾博文, 高山浩昭, 金森岳広, 菊地晶裕, 石井清朗, 金子周一, 篁. 俊成
- Organizer
  第60回日本糖尿病会学術総会
- Data Source
  KAKENHI-PROJECT-16K09740
[Presentation] ヘパトカインセレノプロテインPは骨格筋受容体LRP1を介して運動療法抵抗性を惹起する2016
- Author(s)
  高山浩昭, 御簾博文, 菊地晶裕, 石井清朗, 斎藤芳郎, 金子周一, 篁俊成
- Organizer
  第30回日本糖尿病肥満動物学会
- Place of Presentation
  大宮ソニックシティ(埼玉)
- Year and Date
  2016-03-11
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] Regulation of glucose metabolism and angiogenesis by hepatokines2016
- Author(s)
  Hirofumi Misu
- Organizer
  The 48th Annual Scientific Meeting of the Japan Atherosclerosis Society
- Place of Presentation
  東京
- Year and Date
  2016-07-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09740
[Presentation] ヘパトカインによる全身の恒常性制御2016
- Author(s)
  御簾博文、篁俊成、金子周一
- Organizer
  第3回肝臓と糖尿病・代謝研究会
- Place of Presentation
  金沢
- Year and Date
  2016-07-16
- Invited
- Data Source
  KAKENHI-PROJECT-16K09740
[Presentation] ヘパトカインセレノプロテインPの肥満関連病態に対する多面的効果2016
- Author(s)
  御簾博文、篁俊成
- Organizer
  第37回日本肥満学会
- Place of Presentation
  東京
- Year and Date
  2016-10-07
- Invited
- Data Source
  KAKENHI-PROJECT-16K09740
[Presentation] ヘパトカインセレノプロテインPの過剰産生は筋受容体LRP1を介して運動療法抵抗性の原因となる2016
- Author(s)
  御簾博文篁俊成金子周一
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2016-04-22
- Data Source
  KAKENHI-PROJECT-16K09740
[Presentation] ヘパトカインselenoprotein P・LECT2によるインスリン感受性の制御機構2015
- Author(s)
  御簾博文
- Organizer
  第29回日本糖尿病肥満動物学会
- Place of Presentation
  京都大学
- Year and Date
  2015-02-14
- Invited
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] ヘパトカインSePと筋受容体LRP1よる運動感受性制御2015
- Author(s)
  御簾博文, 高山浩昭, 金子周一, 篁. 俊成
- Organizer
  第30回日本糖尿病合併症学会
- Place of Presentation
  愛知県産業労働センターウインクあいち
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] ヘパトカインセレノプロテインP血中濃度による運動療法抵抗性の予知に関する検討2015
- Author(s)
  御簾博文, 田中睦, 斎藤芳郎, 石井清朗, 竹下有美枝, 金森岳広, 赤澤暢彦, 前田清司, 竹越一博, 金子周一, 篁俊成
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  東京第一ホテル下関 (山口)
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] Hepatokine selenoprotein P induces exercise resistance via skeletal muscle receptor LRP1.2015
- Author(s)
  Hirofumi Misu, Toshinari Takamura and Shuichi Kaneko
- Organizer
  Japan Digestive Disease Week 2015 International Session (Workshop)
- Place of Presentation
  Grand Prince Hotel New Takanawa (Tokyo)
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] Hepatokine selenoprotein P and skeletal muscle receptor LRP1 induce exercise resistance by inhibition of ROS and AMPK.2015
- Author(s)
  Hirofumi Misu
- Organizer
  The 46th NIPS (National Institute of Physiological Science) International Symposium
- Place of Presentation
  Nagoya Congress Center
- Year and Date
  2015-10-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] ヘパトカインセレノプロテインPは筋受容体LRP1を介して“運動療法抵抗性”を惹起する2015
- Author(s)
  高山浩昭, 御簾博文, 斎藤芳郎, 金子周一, 篁俊成
- Organizer
  第27回分子糖尿病シンポジウム
- Place of Presentation
  丸ビルホール＆コンファレンススクエア(東京)
- Year and Date
  2015-12-05
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] A novel role for selenoprotein P in the regulation of insulin sensitivity2014
- Author(s)
  Hirofumi Misu, Yohiro Saito, Kazuhiko Takahashi, Toshinari Takamura, Shuichi Kaneko.
- Organizer
  17th Biennial Meeting of Society for Free Radical Research International (SFRRI 2014)
- Place of Presentation
  Kyoto International Conference Center
- Invited
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] 飽食感知へパトカインLECT2の同定とその機能解析2014
- Author(s)
  御簾博文、篁　俊成、金子周一
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  ホテルニューオータニ(東京)
- Year and Date
  2014-05-29
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] ヘパトカインセレノプロテインPは AMPK不活化を介して運動療法の抵抗性を惹起する2014
- Author(s)
  御簾博文
- Organizer
  第35回日本肥満学会
- Place of Presentation
  宮崎シーガイア
- Year and Date
  2014-10-25
- Invited
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] 2型糖尿病の病態形成におけるヘパトカインセレノプロテインPの役割2014
- Author(s)
  御簾博文
- Organizer
  第29回日本糖尿病合併症学会
- Place of Presentation
  東京都市センターホテル
- Year and Date
  2014-10-03
- Invited
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] インスリン抵抗性誘導ヘパトカインセレノプロテインPの骨格筋における受容体の探索2014
- Author(s)
  御簾博文、高山浩昭、蘭　菲、田島奈津美、菊地晶裕、石井清朗、金子周一、篁　俊成
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  リーガロイヤルホテル大阪
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] 抗酸化ヘパトカインセレノプロテインPはVEGF抵抗性を介して糖尿病性血管新生障害に寄与する2014
- Author(s)
  御簾博文、石倉和秀、斎藤芳郎、金子周一、篁　俊成
- Organizer
  第65回日本酸化ストレス学会学術集会
- Place of Presentation
  同志社大学(京都)
- Year and Date
  2014-09-05
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] 肥満関連へパトカイン LECT2の同定2014
- Author(s)
  御簾博文、Lan Fei、近本啓太、松郷誠一、高山浩昭、山越智、金子周一、篁　俊成
- Organizer
  第87回日本内分泌学会学術総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] 糖尿病関連ヘパトカインセレノプロテインPはVEGF抵抗性を介して血管新生を障害する2014
- Author(s)
  御簾博文、石倉和秀、高山浩昭、金子周一、篁　俊成
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] インスリン抵抗性誘導ヘパトカインセレノプロテインPの同定2012
- Author(s)
  御簾博文
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  日航金沢ホテル、金沢市、石川県
- Year and Date
  2012-06-08
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] 抗酸化ヘパトカインセレノプロテインPによる運動療法抵抗性の発症2012
- Author(s)
  御簾博文　篁俊成　斎藤芳郎　高橋和彦　金子周一
- Organizer
  日本薬学会第132年会(招待講演)
- Place of Presentation
  北海道大学(北海道)
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] H4IIEC肝細胞における活性酸素のインスリンシグナルに対する二面的作用とその分子機構の解明2012
- Author(s)
  御簾博文
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  パシフィコ横浜、横浜市、神奈川県
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] 抗酸化ヘパトカインセレノプロテインP は活性酸素/AMPK/PGC1α経路の抑制を介して運動療法抵抗性の原因となる2012
- Author(s)
  御簾博文
- Organizer
  第65回日本酸化ストレス学会学術集会
- Place of Presentation
  あわぎんホール徳島県郷土文化会館、徳島市、徳島県
- Year and Date
  2012-06-07
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] 抗酸化ヘパトカインセレノプロテインPによる運動療法抵抗性の発症2012
- Author(s)
  御簾博文
- Organizer
  日本薬学会第132年会特別シンポジウム
- Place of Presentation
  北海道大学、札幌市、北海道
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] メトフォルミンはAMPK活性化とFoxO3a活性抑制を介してインスリン抵抗性ヘパトカインセレノプロテインPの発現を抑制する2012
- Author(s)
  御簾博文
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  パシフィコ横浜、横浜市、神奈川県
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] インスリン抵抗性誘導ヘパトカインセレノプロテインPによる運動療法感受性の制御に関する検討2012
- Author(s)
  御簾博文
- Organizer
  第26回日本糖尿病肥満動物学会
- Place of Presentation
  愛知県産業労働センター、名古屋市、愛知県
- Year and Date
  2012-02-18
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] インスリン抵抗性誘導ヘパトカインセレノプロテインPによる運動療法感受性の制御に関する検討2012
- Author(s)
  御簾博文、高山浩昭、金子周一、篁　俊成
- Organizer
  第26回日本糖尿病肥満動物学会
- Place of Presentation
  愛知県産業労働センター(愛知県)
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] ヘパトカインセレノプロテインP は骨格筋ROS/AMPK/PGC1囗経路の抑制を介して運動療法抵抗性を誘導する2012
- Author(s)
  御簾博文
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  パシフィコ横浜、横浜市、神奈川県
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] EPAによるインスリン抵抗性誘導ヘパトカインセレノプロテインP転写活性の抑制2012
- Author(s)
  御簾博文
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  パシフィコ横浜、横浜市、神奈川県
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] 運動療法による脂肪肝改善の分子メカニズムに関する検討2011
- Author(s)
  御簾博文
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌プリンスホテル、札幌市、北海道
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] 2型糖尿病関連ヘパトカインセレノプロテイン P の血管新生抑制作用に関する検討2011
- Author(s)
  御簾博文
- Organizer
  第84回日本内分泌学会学術総会
- Place of Presentation
  神戸国際会議場、神戸市、兵庫県
- Year and Date
  2011-04-23
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] ヘパトカインセレノプロテインPは抗酸化能を介してインスリン抵抗性を誘導する2011
- Author(s)
  御簾博文
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌プリンスホテル、札幌市、北海道
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] メトフォルミンによるインスリン抵抗性誘導ヘパトカインセレノプロテインPの発現抑制に関する検討2011
- Author(s)
  御簾博文
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌プリンスホテル、札幌市、北海道
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] Circulating levels of selenoprotein P predict future hyperglycemia in nondiabetic Japanese people
- Author(s)
  Hirofumi Misu, Takehiro Kanamori, YumieTakeshita, Yohiro Saito, Mutsumi Tanaka, Shuichi Kaneko, Toshinari Takamura.
- Organizer
  49th Annual Meeting of the European Association for the Study of Diabetes (EASD2013)
- Place of Presentation
  Fila de Barcelona's Gran Via exhibition centre, Spain
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] インスリン抵抗性誘導へパトカインセレノプロテインPによる高血糖発症予知に関する検討
- Author(s)
  御簾博文, 田中睦, 斎藤芳郎, 竹下有美枝, 喜多裕樹, 中源雅俊, 長野亨, 金子周一, 篁俊成.
- Organizer
  第56回日本糖尿病年次学術集会
- Place of Presentation
  熊本市民会館
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] ヘパトカインセレノプロテインPは活性酸素/AMPK/PGC1α経路の抑制を介して”運動療法抵抗性”を誘導する
- Author(s)
  御簾博文, 蘭菲, 近本啓太, 高山浩昭, 菊地昌裕, 斎藤芳郎, 金子周一, 篁俊成.
- Organizer
  第36回日本分子生物学会年次学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25461334
[Presentation] EPAによるインスリン抵抗性誘導ヘパトカインセレノプロテインP転写活性の抑制
- Author(s)
  御簾博文 (他5名、3番目)
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  パシフィコ横浜アネックスホール、横浜
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] H4IIEC肝細胞における活性酸素のインスリンシグナルに対する二面的作用とその分子機構の解明
- Author(s)
  御簾博文 (他6名、2番目)
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  パシフィコ横浜アネックスホール、横浜
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] ヘパトカインセレノプロテインPは骨格筋ROS/AMPK/PGC1経路の抑制を介して運動療法抵抗性を誘導する
- Author(s)
  御簾博文 (他7名、1番目)
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  パシフィコ横浜アネックスホール、横浜
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] メトフォルミンはAMPK活性化とFoxO3a活性抑制を介してインスリン抵抗性ヘパトカインセレノプロテインPの発現を抑制する
- Author(s)
  御簾博文 (他8名、2番目)
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  パシフィコ横浜アネックスホール、横浜
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] 抗酸化ヘパトカインセレノプロテインPは活性酸素/AMPK/PGC1α経路の抑制を介して運動療法抵抗性の原因となる
- Author(s)
  御簾博文 (他5名、1番目)
- Organizer
  第65回日本酸化ストレス学会学術集会
- Place of Presentation
  あわぎんホール徳島県郷土文化会館、徳島
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] インスリン抵抗性誘導ヘパトカインセレノプロテインPの同定
- Author(s)
  御簾博文 (他2名、1番目)
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  ホテル日航金沢、金沢
- Data Source
  KAKENHI-PROJECT-23791022
[Presentation] ヘパトカインセレノプロテインPによる運動療法抵抗性発症に関する検討
- Author(s)
  御簾博文, Lan Fei, 高山浩昭, 金子周一, 篁俊成.
- Organizer
  第86回日本内分泌学会学術総会
- Place of Presentation
  仙台国際会議場
- Data Source
  KAKENHI-PROJECT-25461334
[]

1. KANEKO Shuichi (60185923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. 本多政夫 (00272980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. 井上啓 (50397832)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 篁俊成 (00324111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
5. 水腰英四郎 (90345611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 竹下有美枝 (40507042)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. 太田嗣人 (60397213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 岡田光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 高倉伸幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 菊地晶裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 高村雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MISU Hirofumi 御簾 博文

Research Projects

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Identification of a novel transcription factor that regulates diabetes-related hepatokine.Principal Investigator

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Study of the liver as an endocrine organ

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Investigation of exercise resistance induced by hepatokine selenoprotein PPrincipal Investigator

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Screening for therapies of diabetes targeting novel hepatokine selenoprotein P that induces insulin resistancePrincipal Investigator

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[Journal Article] Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity.2019

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[Journal Article] p62-mediated autophagy affects nutrition-dependent insulin receptor substrate 1 dynamics in 3T3-L1 preadipocytes2019

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[Journal Article] Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans2019

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[Journal Article] Identification of hepatokines involved in pathology of type 2 diabetes and obesity2019

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[Journal Article] Effects of metformin and alogliptin on body composition in people with type 2 diabetes.2018

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[Journal Article] Inhibin betaE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples2018

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[Journal Article] Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population.2018

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[Journal Article] Comparison of Human Selenoprotein P Determinants in Serum between Our Original Methods and Commercially Available Kits2018

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[Journal Article] Ursodeoxycholic acid potentiates dipeptidyl peptidase-4 inhibitor sitagliptin by enhancing glucagon-like peptide-1 secretion in patients with type 2 diabetes and chronic liver disease: a pilot randomized controlled and add-on study2018

MISU Hirofumi 御簾博文