Kaneto Hideaki 金藤秀明

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KANETO Hideaki 金藤秀明

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Researcher Number	80448034
Other IDs
Affiliation (Current)	2025: 川崎医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2013 – 2024: 川崎医科大学, 医学部, 教授 2012: 大阪大学, 医学(系)研究科(研究院), 准教授 2012: 大阪大学, 医学(系)研究科, 准教授 2011: 大阪大学, 医学系・研究科, 准教授 2011: 大阪大学, 医学系研究科, 准教授 2009 – 2010: Osaka University, 医学系研究科, 講師
Review Section/Research Field	Principal Investigator Metabolomics / Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Metabolomics / Basic Section 54040:Metabolism and endocrinology-related
Keywords	Principal Investigator 膵β細胞 / インスリン転写因子 / ブドウ糖毒性 / 糖尿病 / 転写因子 / 膵β細胞ブドウ糖毒性 / SGLT2阻害薬 / インクレチン受容体 / 新規糖尿病治療薬 / 膵β細胞糖毒性 … More / インスリン遺伝子 / 膵β細胞機能 / 銅キレート剤 / 銅イオン / フェントン反応 / インスリン抵抗性 / インクレチン / インスリン / インスリン分泌 / インスリン合成 / 酸化ストレス … More Except Principal Investigator 糖尿病 / 糖尿病大血管症 / 膵β細胞 / Mafa / RNAメチレーション / アンジオテンシンII / 骨細胞様細胞 / 骨芽細胞 / IL-1 / IL-17 / 血管平滑筋細胞 / 乾癬 / 動脈硬化 / 慢性炎症 / IL-17A / 大動脈 / 炎症性サイトカイン / 血管石灰化 / baPWV / 脈波伝播速度 / 遺伝子多型 / 超音波組織性状 / IMT / 頸動脈エコー / 心血管疾患 / インスリン転写因子 / インスリン合成 / インスリン / ｲﾝｽﾘﾝ転写因子 / ｲﾝｽﾘﾝ合成 / SNP / 遺伝子診断 / 酸化ストレス / c-Jun / MafA / C-Jun / 活性酸素 Less

ブドウ糖毒性が膵ラ氏島のm6A RNAメチル化不全に与える影響
- Principal Investigator
  
  木村友彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kawasaki Medical School
膵β細胞ブドウ糖毒性から見た新規糖尿病治療薬の探索Principal Investigator
- Principal Investigator
  
  金藤秀明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kawasaki Medical School
Pathophysiological analysis of vascular calcification
- Principal Investigator
  
  Fujita Shunichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kawasaki Medical School
Comprehensive searching for compounds which can directly enhance MafA and/or PDX-1 expressionPrincipal Investigator
- Principal Investigator
  
  Kaneto Hideaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kawasaki Medical School
Investigation of novel diabetic medicine based on glucose toxicityPrincipal Investigator
- Principal Investigator
  
  Hideaki Kaneto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kawasaki Medical School
Development of non-invasive risk stratification systems for diabetic macroangiopathy
- Principal Investigator
  
  KATAKAMI NAOTO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Osaka University
Molecular mechanism for pancreatic beta-cell glucose toxicityPrincipal Investigator
- Principal Investigator
  
  HIDEAKI Kaneto
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kawasaki Medical School
  Osaka University
Analysis for new target gene of Mafa, and application for pancreatic beta-cell generation.
- Principal Investigator
  
  MATSUOKA Takaaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Osaka University
Evaluation of the effects of the accumulation of gene polymorphismsrelated to oxidative stress on diabetic macroangiopathy
- Principal Investigator
  
  KATAKAMI Naoto
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Osaka University
Evaluation for significant role of Mafa under Type2 diabetic conditions
- Principal Investigator
  
  MATUOKA Takaaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Osaka University
Molecular mechanism for pancreatic beta-cell glucose toxicityPrincipal Investigator
- Principal Investigator
  
  KANETO Hideaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Osaka University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009

All Journal Article Presentation Book

[Book] 「インスリン療法とインクレチン注射療法の差別化」Diabetes in the News2011
- Author(s)
  金藤秀明
- Data Source
  KAKENHI-PROJECT-21591135
[Book] 「インクレチンの膵β細胞保護・増殖作用」日本臨床特集インクレチン関連薬2011
- Author(s)
  河盛段、金藤秀明
- Data Source
  KAKENHI-PROJECT-21591135
[Book] 「DPP-4阻害薬」月刊糖尿病別冊糖尿病治療薬ハンドブック2011
- Author(s)
  高原充佳、金藤秀明
- Data Source
  KAKENHI-PROJECT-21591135
[Book] 「酸化ストレスと小胞体ストレス」日本臨床メタボリックシンドローム-基礎・臨床の最新知見-2011
- Author(s)
  金藤秀明
- Data Source
  KAKENHI-PROJECT-21591135
[Book] 「2型糖尿病の病態および最近の薬物療法」守口市医師会会報2011
- Author(s)
  金藤秀明
- Data Source
  KAKENHI-PROJECT-21591135
[Book] 「酸化ストレスとインスリン合成・分泌障害」糖尿病と酸化ストレス2011
- Author(s)
  金藤秀明、松岡孝昭
- Data Source
  KAKENHI-PROJECT-21591135
[Book] 「膵β細胞ブドウ糖毒性の分子メカニズム」糖尿病学の進歩2010
- Author(s)
  金藤秀明
- Data Source
  KAKENHI-PROJECT-21591135
[Book] 「インクレチンとは、どこから出るホルモンですか?」特集:インクレチン製剤-基礎と臨床肥満と糖尿病2010
- Author(s)
  高原充佳、金藤秀明
- Data Source
  KAKENHI-PROJECT-21591135
[Book] 「糖尿病治療の実際とガイドライン」「糖尿病治療薬」座談会治療学2010
- Author(s)
  金藤秀明
- Data Source
  KAKENHI-PROJECT-21591135
[Book] 「糖尿病とストレス応答」循環器ストレス学2009
- Author(s)
  金藤秀明、松岡孝昭
- Data Source
  KAKENHI-PROJECT-21591135
[Book] 「糖毒性」糖尿病ナビゲーター2009
- Author(s)
  金藤秀明、松岡孝昭
- Data Source
  KAKENHI-PROJECT-21591135
[Book] 「小胞体ストレスとインスリン抵抗性」カラー版糖尿病学アップデート版I2009
- Author(s)
  金藤秀明
- Data Source
  KAKENHI-PROJECT-21591135
[Book] 「インスリン遺伝子転写調節のメカニズム」糖尿病ナビゲーター2009
- Author(s)
  金藤秀明、松岡孝昭
- Data Source
  KAKENHI-PROJECT-21591135
[Book] 「膵細胞におけるインクレチンの役割」クリニシャン2009
- Author(s)
  金藤秀明
- Data Source
  KAKENHI-PROJECT-21591135
[Book] 「転写因子の核内輸送と糖代謝調節-膵β細胞を中心に-」Diabetes Frontier2009
- Author(s)
  金藤秀明、松岡孝昭、河盛段、松久宗英
- Data Source
  KAKENHI-PROJECT-21591135
[Book] 「インクレチンによる膵細胞増殖」糖尿病治療のUp-to-Date2009
- Author(s)
  金藤秀明、松岡孝昭、松久宗英
- Data Source
  KAKENHI-PROJECT-21591135
[Journal Article] Effect of hyperglycemia-related acute metabolic disturbance on thyroid function parameters in adults.2022
- Author(s)
  Iwamoto Y, Kimura T, Tatsumi F, Sugisaki T, Kubo M, Nakao E, Dan K, Wamata R, Iwamoto H, Takahashi K, Sanada J, Fushimi Y, Katakura Y, Shimoda M, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Front. Endocrinol.
  
  Volume: 13 Pages: 869869-869869
- DOI
  10.3389/fendo.2022.869869
- Data Source
  KAKENHI-PROJECT-22K08638
[Journal Article] Glucagon test is a useful predictor of withdrawal from insulin therapy in subjects with type 2 diabetes mellitus.2022
- Author(s)
  Iwamoto Y, Kimura T, Tatsumi F, Sugisaki T, Kubo M, Nakao E, Dan K, Wamata R, Iwamoto H, Takahashi K, Sanada J, Fushimi Y, Katakura Y, Shimoda M, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Front. Endocrinol.
  
  Volume: 13 Pages: 871660-871660
- DOI
  10.3389/fendo.2022.871660
- Data Source
  KAKENHI-PROJECT-22K08638
[Journal Article] Correlation of Baba's diabetic neuropathy classification with various diabetes-related complications.2022
- Author(s)
  Iwamoto Y, Nakanishi S, Itoh T, Iwamoto H, Sanada J, Fushimi Y, Katakura Y, Kimura T, Tatsumi F, Shimoda M, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Front. Endocrinol.
  
  Volume: 13 Pages: 1054934-1054934
- DOI
  10.3389/fendo.2022.1054934
- Data Source
  KAKENHI-PROJECT-22K08638
[Journal Article] Molecular Mechanism of Pancreatic β-Cell Failure in Type 2 Diabetes Mellitus. Biomedicines.2022
- Author(s)
  Kaneto H, Kimura T, Shimoda M, Obata A, Sanada J, Fushimi Y, Matsuoka TA, Kaku K.
- Journal Title
  
  Biomedicines.
  
  Volume: 31 Issue: 4 Pages: 818-831
- DOI
  10.3390/biomedicines10040818
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08540, KAKENHI-PROJECT-22K08638
[Journal Article] Imeglimin exerts favorable effects on pancreatic β-cells by improving morphology in mitochondria and increasing the number of insulin granules.2022
- Author(s)
  Sanada J, Obata A, Fushimi Y, Kimura T, Shimoda M, Ikeda T, Nogami Y, Obata Y, Yamasaki Y, Nakanishi S, Mune T, Kaku K, Kaneto H.
- Journal Title
  
  Sci Rep.
  
  Volume: 12 Issue: 1 Pages: 13220-13220
- DOI
  10.1038/s41598-022-17657-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08540, KAKENHI-PROJECT-22K08638
[Journal Article] Association between changes in pancreatic morphology and vascular complications in subjects with type 2 diabetes mellitus: A retrospective study.2022
- Author(s)
  Iwamoto Y, Kimura T, Tatsumi F, Sugisaki T, Kubo M, Nakao E, Dan K, Wamata R, Iwamoto H, Takahashi K, Sanada J, Fushimi Y, Katakura Y, Shimoda M, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Scientific Rep.
  
  Volume: 12 Issue: 1 Pages: 17166-17166
- DOI
  10.1038/s41598-022-21688-1
- Data Source
  KAKENHI-PROJECT-22K08638
[Journal Article] Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History2021
- Author(s)
  Kaneto H, Kimura T, Obata A, Shimoda M, Kaku K.
- Journal Title
  
  Int J Mol Sci .
  
  Volume: 22 Issue: 5 Pages: 2596-2596
- DOI
  10.3390/ijms22052596
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18016, KAKENHI-PROJECT-19K08990, KAKENHI-PROJECT-21K08540
[Journal Article] Favorable effects of GLP-1 receptor activator against pancreatic beta-cell glucose toxicity and the development of arteriosclerosis: “The earlier, the better” in therapy with incretin-based medicine.2021
- Author(s)
  Kaneto H, Kimura T, Shimoda M, Obata A, Sanada J, Fushimi Y, Nakanishi S, Mune T, and Kaku K.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 22 Issue: 15 Pages: 7917-7917
- DOI
  10.3390/ijms22157917
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08990, KAKENHI-PROJECT-21K08540
[Journal Article] Unexpected Pleiotropic Effects of SGLT2 Inhibitors: Pearls and Pitfalls of This Novel Antidiabetic Class2021
- Author(s)
  Kaneto H, Obata A, Kimura T, Shimoda M, Kinoshita T, Matsuoka TA, Kaku K.
- Journal Title
  
  Int J Mol Sci .
  
  Volume: 22 Issue: 6 Pages: 3062-3062
- DOI
  10.3390/ijms22063062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18016, KAKENHI-PROJECT-19K08990, KAKENHI-PROJECT-21K08540
[Journal Article] Notable underlying mechanism for pancreatic beta-cell dysfunction and atherosclerosis: Pleiotropic role of incretin and insulin signaling in various situation.2020
- Author(s)
  Kaneto H, Obata A, Kimura T, Shimoda M, Sanada J, Fushimi Y, Katakami N, Matsuoka T, and Kaku K.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 21 Issue: 24 Pages: 1-13
- DOI
  10.3390/ijms21249444
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08990, KAKENHI-PROJECT-19K18016
[Journal Article] Vascular endothelial PDK1 plays pivotal roles for maintenance of pancreatic beta-cell mass and function in adult male mice.2019
- Author(s)
  Obata A, Kimura T, Obata Y, Shimoda M, Kinoshita T, Kohara K, Okauchi S, Hirukawa H, Kamei S, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Diabetologia
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Vascular endothelial PDK1 plays pivotal roles for maintenance of pancreatic beta-cell mass and function in adult male mice.2019
- Author(s)
  Obata A, Kimura T, Obata Y, Shimoda M, Kinoshita T, Kohara K, Okauchi S, Hirukawa H, Kamei S, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Diabetologia
  
  Volume: 62 Issue: 12 Pages: 1225-1236
- DOI
  10.1007/s00125-019-04982-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08990
[Journal Article] Pancreatic alpha-cells in diabetic rats express active GLP-1 receptor: Evidence for GLP-1 signaling that regulates intra-islet paracrine mechanism.2018
- Author(s)
  Nakashima K, Kaneto H, Shimoda M, Kimura T, and Kaku K.
- Journal Title
  
  Scientific Rep.
  
  Volume: 1 Issue: 1 Pages: 1-14
- DOI
  10.1038/s41598-018-21751-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Durability of protective effect of dulaglutide on pancreatic beta-cells in diabetic mice: GLP-1 receptor expression is not reduced at all even after long-term exposure to dulaglutide.2018
- Author(s)
  Kimura T, Obata A, Shimoda M, Hirukawa H, Kanda-Kimura Y, Nogami Y, Kohara K, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Diabetes Metab.
  
  Volume: 44 Pages: 250-260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic beta-cells in obese diabetic db/db mice: The earlier and longer, the better.2018
- Author(s)
  Kimura T, Obata A, Shimoda M, Okauchi S, Kanda-Kimura Y, Nogami Y, Hirukawa H, Kohara K, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Diabetes Obes. Metab.
  
  Volume: 20 Pages: 2442-2457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Increase of cortisol / ACTH ratio after chronic treatment with liraglutide in subjects with type 2 diabetes mellitus.2017
- Author(s)
  Kamei S, Kaneto H, Tanabe A, Kinoshita T, Obata A, Kimura T, Hirukawa H, Tatsumi F, Shimoda M, Kohara K, Anno T, Nakanishi S, Mune T, and Kaku K.
- Journal Title
  
  Diabetes Metab
  
  Volume: 43 Issue: 4 Pages: 398-399
- DOI
  10.1016/j.diabet.2017.01.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Beneficial effects of SGLT2 inhibitors for preservation of pancreatic beta-cell function and reduction of insulin resistance.2017
- Author(s)
  Kaneto H, Obata A, Kimura T, Shimoda M, Okauchi S, Shimo N, Matsuoka T, and Kaku K.
- Journal Title
  
  J. Diabetes
  
  Volume: 9 Issue: 3 Pages: 219-225
- DOI
  10.1111/1753-0407.12494
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic β-cells in obese type 2 diabetic db/db mice.2016
- Author(s)
  Okauchi S, Shimoda M, Obata A, Kimura T, Hirukawa H, Kohara K, Mune T, Kaku K, Kaneto H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 470 Issue: 3 Pages: 772-782
- DOI
  10.1016/j.bbrc.2015.10.109
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461350, KAKENHI-PROJECT-16K09770
[Journal Article] Clinical effects of liraglutide are possibly influenced by hypertriglyceridemia and remaining pancreatic beta-cell function in subjects with type 2 diabetes mellitus.2016
- Author(s)
  Tanabe A, Kaneto H, Kamei S, Hirukawa H, Shimoda M, Kimura T, Obata A, Okauchi S, Tatsumi F, Kohara K, Mune T, and Kaku K.
- Journal Title
  
  J. Diabetes Complications
  
  Volume: 30 Pages: 1201-1203
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Promising diabetes therapy based on the molecular mechanism for glucose toxicity: Usefulness of SGLT2 inhibitors as well as incretin-related drugs.2016
- Author(s)
  Kaneto H, Obata A, Shimoda M, Kimura T, Hirukawa H, Okauchi S, Matsuoka T, and Kaku K.
- Journal Title
  
  Curr. Med. Chem.
  
  Volume: 23 Pages: 3044-3051
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Protective effects of pioglitazone and/or liraglutide on pancreatic beta-cells: comparison of their effects between in an early and advanced stage of diabetes.2015
- Author(s)
  Kimura T, Kaneto H, Shimoda M, Hirukawa H, Okauchi S, Kohara K, Hamamoto S, Tawaramoto K, Hashiramoto M, Kaku K.
- Journal Title
  
  Mol. Cell. Endocrinol.
  
  Volume: 400 Pages: 78-89
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591327
[Journal Article] Pancreatic beta-cell glucose toxicity in type 2 diabetes mellitus.2015
- Author(s)
  Kaneto H
- Journal Title
  
  Curr. Diabetes Rev.
  
  Volume: 11 Pages: 2-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591327
[Journal Article] Role of pancreatic transcription factors in maintenance of mature beta-cell function.2015
- Author(s)
  Kaneto H, Matsuoka T
- Journal Title
  
  Int. J. Mol. Sci
  
  Volume: 16 Pages: 6281-6297
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591327
[Journal Article] Preserving MafA expression in diabetic islet beta-cells improves glycemic control in vivo.2015
- Author(s)
  Matsuoka T, Kaneto H, Kawashima S, Miyatsuka T, Tochino Y, Yoshikawa A, Imagawa A, Miyazaki J, Gannon M, Stein R, Shimomura I.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Pages: 7647-7657
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591327
[Journal Article] Preserving Mafa expression in diabetic islet β-cells improves glycemic control in vivo.2015
- Author(s)
  Matsuoka TA, Kaneto H, Kawashima S, Miyatsuka T, Tochino Y, Yoshikawa A, Imagawa A, Miyazaki JI, Gannon M, Stein R, Shimomura I.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Issue: 12 Pages: 7647-57
- DOI
  10.1074/jbc.m114.595579
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591328
[Journal Article] Carotid ultrasonograpy: a potent tool for better clinical practice of atherosclerosis in diabetic patients.2014
- Author(s)
  Katakami N, Kaneto H, Shimomura I.
- Journal Title
  
  Journal of Diabetes Investigation 2013
  
  Volume: 5 Issue: 1 Pages: 3-13
- DOI
  10.1111/jdi.12106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461349
[Journal Article] Accumulation of oxidative-stress related gene polymorphisms and the risk of coronary heart disease events in type 2 diabetes in an 8-year follow-up.2014
- Author(s)
  1.Katakami N, Kaneto H, Matsuoka TA, Takahara M, Osonoi T, Saitou M, Kawai K, Ishibashi F, IKashiwagi A, Kawamori R, Shimomura I, Yamasaki Y
- Journal Title
  
  Atherosclerosis
  
  Volume: 235 Issue: 2 Pages: 408-414
- DOI
  10.1016/j.atherosclerosis.2014.05.936
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461349
[Journal Article] The utility of ultrasonic tissue characterization of carotid plaque in the prediction of cardiovascular events in diabetic patients.2013
- Author(s)
  Irie Y, Katakami N, Kaneto H, Takahara M, Nishio M, Kasami R, Sakamoto K, Umayahara Y, Sumitsuji S, Ueda Y, Kosugi K, Shimomura I.
- Journal Title
  
  Atherosclerosis
  
  Volume: 230 Issue: 2 Pages: 399-405
- DOI
  10.1016/j.atherosclerosis.2013.08.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461349
[Journal Article] The utility of carotid ultrasonography in identifying severe coronary artery disease in asymptomatic type 2 diabetes patients without history of coronary artery disease.2013
- Author(s)
  Irie Y, Katakami N, Kaneto H, Nishio M, Kasami R, Sakamoto K, Umayahara Y, Sumitsuji S, Ueda Y, Kosugi K, Shimomura I.
- Journal Title
  
  Diabetes Care
  
  Volume: 36 Issue: 5 Pages: 1327-1334
- DOI
  10.2337/dc12-1327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461349
[Journal Article] Molecular mechanism for pancreatic beta-cell glucose toxicity:　Down-regulation of insulin gene transcription factors and incretin receptors.2013
- Author(s)
  Kaneto, H. and Matsuoka, T.
- Journal Title
  
  World J. Diabetes
  
  Volume: 15 Pages: 263-269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591327
[Journal Article] A novel function of Onecut 1 as a negative regulator of MafA.2013
- Author(s)
  Yamamoto, K., Matsuoka, T., Kawashima, S., Takebe, S., Kubo, N., Miyatsuka, T., Kaneto, H., and Shimomura, I.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Pages: 21648-21658
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591327
[Journal Article] Involvement of oxidative stress in suppression of insulin biosynthesis under diabetic conditions.2012
- Author(s)
  Kaneto, H. and Matsuoka, T.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 13 Pages: 13680-13690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591327
[Journal Article] Effect of alogliptin, pioglitazone and glargine on pancreatic β-cells in diabetic db/db mice.2011
- Author(s)
  Kawashima S, Matsuoka T, Kaneto H, Tochino Y., Kato K, Yamamoto K, Yamamoto T, Matsuhisa M, Shimomura I.
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 404 Pages: 534-540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591135
[Journal Article] Effect of alogliptin, pioglitazone and glargine on pancreaticβ-cells in diabetic db/ db mice2011
- Author(s)
  Kawashima, S., Matsuoka, T., Kaneto, H., Tochino, Y., Kato, K., Yamamoto, K., Yamamoto, T., Matsuhisa, M., and Shimomura, I.
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 404 Pages: 534-540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591135
[Journal Article] Effect of alogliptin, pioglitazone and glargine on pancreatic β-cells in diabetic db/db mice2011
- Author(s)
  Kawashima S, Matsuoka T, Kaneto H, Tochino Y., Kato K, Yamamoto K, Yamamoto T, Matsuhisa M, Shimomura I
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 404 Pages: 534-540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591135
[Journal Article] Accumulation of gene polymorphisms related to oxidative stress is associated with myocardial infarction in Japanese type 2 diabetic patients.2010
- Author(s)
  Katakami N, Kaneto H, et al.
- Journal Title
  
  Atherosclerosis
  
  Volume: 212 Pages: 534-538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590980
[Journal Article] Regulation of MafA expression in pancreaticβ-cells in db/ db mice with diabetes2010
- Author(s)
  Matsuoka, T., Kaneto, H., Miyatsuka, T., Yamamoto, T., Yamamoto, K., Kato, K., Shimomura, I., Stein, R., and Matsuhisa, M.
- Journal Title
  
  Diabetes
  
  Volume: 59 Pages: 1709-1720
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591135
[Journal Article] Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis2010
- Author(s)
  Kaneto, H., Katakami, N., Matsuhisa, M., and Matsuoka, T.
- Journal Title
  
  Mediators Inflamm
  
  Volume: 453892 Pages: 1-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591135
[Journal Article] Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis2010
- Author(s)
  Kaneto H, Katakami N., Matsuhisa M, Matsuoka T.
- Journal Title
  
  Mediators Inflamm.
  
  Volume: 453892 Pages: 1-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591135
[Journal Article] Accumulation of gene polymorphisms related to oxidative stress is associated with myocardial infarction in Japanese type 2 diabetic patients2010
- Author(s)
  Katakami N, Kaneto H, Matsuoka TA
- Journal Title
  
  Atherosclerosis
  
  Volume: 201 Pages: 534-538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590980
[Journal Article] Combination of MafA, PDX-1 and NeuroD is a useful tool to efficiently induce insulin-producing surrogate β-cells2009
- Author(s)
  Kaneto H, et al
- Journal Title
  
  Curr.Med.Chem. 16
  
  Pages: 3144-3151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591135
[Journal Article] Role of MafA in pancreaticβ-cells2009
- Author(s)
  Kaneto, H., Matsuoka, T., Kawashima, S., Yamamoto, K., Kato, K., Miyatsuka, T., Katakami, N., and Matsuhisa, M.
- Journal Title
  
  Adv. Drug Deliv. Rev
  
  Volume: 61 Pages: 489-496
- Data Source
  KAKENHI-PROJECT-21591135
[Journal Article] Combination of MafA, PDX-1 and NeuroD is a useful tool to efficiently induce insulin-producing surrogateβ-cells2009
- Author(s)
  Kaneto, H., Matsuoka, T., Katakami, N., and Matsuhisa, M.
- Journal Title
  
  Curr. Med. Chem
  
  Volume: 16 Pages: 3144-3151
- Data Source
  KAKENHI-PROJECT-21591135
[Journal Article] Role of copper ion in the pathogenesis of type 2 diabetes2009
- Author(s)
  Tanaka, A., Kaneto, H., Miyatsuka, T., Yamamoto, K, Yoshiuchi, K., Yamasaki, Y., Shimomura, I., Matsuoka, T., and Matsuhisa, M.
- Journal Title
  
  Endocr. J
  
  Volume: 56 Pages: 699-706
- NAID
  10026914641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] ２型糖尿病の病態と治療に関するトピックス2018
- Author(s)
  金藤　秀明
- Organizer
  第21回日本病態栄養学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09770
[Presentation] 糖尿病における早期治療の重要性2018
- Author(s)
  金藤　秀明
- Organizer
  第36回日本肥満症治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09770
[Presentation] 2型糖尿病の病態および治療に関するトピックス2018
- Author(s)
  金藤　秀明
- Organizer
  日本糖尿病学会中四国地方会第56回総会
- Data Source
  KAKENHI-PROJECT-16K09770
[Presentation] Lipotoxicity2018
- Author(s)
  金藤　秀明
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09770
[Presentation] 非侵襲的アプローチによる頸動脈壁組織性状の定量評価とその臨床的有用性2013
- Author(s)
  片上直人、高原充佳、金藤秀明、坂本賢哉、吉内和富、坂本扶美枝、入江陽子、久保典代、桂　央士、山崎義光、小杉圭右、下村伊一郎
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25461349
[Presentation] 冠動脈疾患の既往がない無症候2型糖尿病患者において頚動脈内膜中膜複合体肥厚度は重症冠動脈疾患のスクリーニングに有用である2013
- Author(s)
  入江陽子、片上直人、金藤秀明、嵩　龍一、坂本賢哉、小杉圭右、馬屋原　豊、下村伊一郎
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25461349
[Presentation] 2型糖尿病の病態と最近の薬物療法2011
- Author(s)
  金藤秀明
- Organizer
  Oita Diabetes Expert Club
- Place of Presentation
  大分
- Year and Date
  2011-02-28
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 膵β細胞ブドウ糖毒性の分子機構2011
- Author(s)
  金藤秀明
- Organizer
  膵内分泌を考える会
- Place of Presentation
  福井
- Year and Date
  2011-08-19
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 膵β細胞におけるインクレチンの重要性2011
- Author(s)
  金藤秀明
- Organizer
  大阪内分泌代謝ジョイントカンファレンス
- Place of Presentation
  大阪
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 2型糖尿病の病態および最近の薬物治療2011
- Author(s)
  金藤秀明
- Organizer
  守口市医師会学術講演会
- Place of Presentation
  守口
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 膵β細胞糖毒性の分子メカニズム2011
- Author(s)
  金藤秀明
- Organizer
  第18回北野糖尿病内分泌倶楽部
- Place of Presentation
  大阪
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 糖尿病治療における最新の話題～インクレチン剤を含めた経口糖尿病薬の使い分け～2011
- Author(s)
  金藤秀明
- Organizer
  赤穂市医師会学術講演会
- Place of Presentation
  赤穂
- Year and Date
  2011-02-04
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] How could we bring out theusefulness of incretin therapy?2011
- Author(s)
  金藤秀明
- Organizer
  シンポジウムインスリン発見から90年-インスリン治療の現状と展望-第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 2型糖尿病の薬物療法～インクレチン製剤を中心に～2011
- Author(s)
  金藤秀明
- Organizer
  大阪糖尿病アカデミー
- Place of Presentation
  大阪
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] メタボリックシンドロームに潜む健康リスク-正しく理解し糖尿病を予防するために-2011
- Author(s)
  金藤秀明
- Organizer
  働く人々のための健康フォーラム
- Place of Presentation
  大阪
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 膵β細胞ブドウ糖毒性の分子機構-酸化ストレスおよびインクレチンを中心に-2011
- Author(s)
  金藤秀明
- Organizer
  第4回東京糖尿病治療フォーラム
- Place of Presentation
  東京
- Year and Date
  2011-04-27
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 微侵襲食後高血糖モニタリングシステムの薬効評価への適用2011
- Author(s)
  金藤秀明
- Organizer
  第3回微侵襲食後高血糖モニタリングシステム研究会
- Place of Presentation
  大阪
- Year and Date
  2011-08-08
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 2型糖尿病の病態と最近の薬物治療2011
- Author(s)
  金藤秀明
- Organizer
  千里医師連合会学術講演会
- Place of Presentation
  大阪
- Year and Date
  2011-07-30
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 糖尿病の研究および臨床の魅力2011
- Author(s)
  金藤秀明
- Organizer
  第5回大阪糖尿病臨床カンファレン
- Place of Presentation
  大阪
- Year and Date
  2011-08-27
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] Role of MafA in pancreaticbeta-cells2011
- Author(s)
  金藤秀明
- Organizer
  第5回Diabetes Leading-edgeConference
- Place of Presentation
  滋賀
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 膵β細胞ブドウ糖毒性の分子機構-インスリン、インクレチンを中心に-2011
- Author(s)
  金藤秀明
- Organizer
  房総糖尿病セミナー
- Place of Presentation
  千葉
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 膵β細胞ブドウ糖毒性の分子機構の解析および膵β細胞への分化転換の試み2011
- Author(s)
  金藤秀明
- Organizer
  第29回大阪糖尿病研究会
- Place of Presentation
  大阪
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 2型糖尿病の薬物療法～インクレチン製剤を中心に～2011
- Author(s)
  金藤秀明
- Organizer
  インクレチン研究会-循環器医編-
- Place of Presentation
  神戸
- Year and Date
  2011-09-29
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 2型糖尿病の病態および最近の薬物療法2011
- Author(s)
  金藤秀明
- Organizer
  千里糖尿病セミナー
- Place of Presentation
  大阪
- Year and Date
  2011-01-27
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 2型糖尿病の病態および最近の薬物治療2010
- Author(s)
  金藤秀明
- Organizer
  第53回日本DDS学会ランチョンセミナ
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 膵β細胞ブドウ糖毒性の分子機構-酸化ストレスおよびインクレチンを中心に-2010
- Author(s)
  金藤秀明
- Organizer
  インクレチン研究会in阪神
- Place of Presentation
  西宮
- Year and Date
  2010-01-23
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] Molecular mechanism for pancreatic beta-cell glucose toxicity2010
- Author(s)
  金藤秀明
- Organizer
  シンポジウムbeta cell failure～beta細胞不全の原因とそのメカニズム第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 2型糖尿病の病態解明および最近の薬物治療2010
- Author(s)
  金藤秀明
- Organizer
  北河内糖尿病座談会
- Place of Presentation
  大阪
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 膵β細胞糖毒性の分子メカニズム2010
- Author(s)
  金藤秀明
- Organizer
  第44回糖尿病学の進歩
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 2型糖尿病の病態および最近の薬物治療2010
- Author(s)
  金藤秀明
- Organizer
  病診連携の会
- Place of Presentation
  大阪
- Year and Date
  2010-09-18
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 2型糖尿病の病態解明および膵β細胞の分化再生治療に向けて2010
- Author(s)
  金藤秀明
- Organizer
  第42回ニ季会
- Place of Presentation
  大阪
- Year and Date
  2010-08-21
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 膵β細胞ブドウ糖毒性の分子機構2010
- Author(s)
  金藤秀明
- Organizer
  糖尿病治療カンファレンス
- Place of Presentation
  大阪
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 2型糖尿病の病態解明および膵β細胞の分化再生療法に向けて2010
- Author(s)
  金藤秀明
- Organizer
  Diabetes Face to Face
- Place of Presentation
  大阪
- Year and Date
  2010-11-25
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 酸化ストレスを介した膵β細胞機能障害の分子機構2009
- Author(s)
  金藤秀明
- Organizer
  大分大学研究会
- Place of Presentation
  大分
- Year and Date
  2009-02-13
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 膵β細胞の障害因子2009
- Author(s)
  金藤秀明
- Organizer
  栃木県糖尿病専門医会
- Place of Presentation
  栃木
- Year and Date
  2009-07-24
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 膵における転写因子PDX-1の重要性2009
- Author(s)
  金藤秀明
- Organizer
  The Study of Molecular Diabetology
- Place of Presentation
  仙台
- Year and Date
  2009-06-22
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 膵β細胞ブドウ糖毒性の分子機構-酸化ストレスおよびインクレチンを中心に-2009
- Author(s)
  金藤秀明
- Organizer
  糖尿病学術講演会
- Place of Presentation
  富山
- Year and Date
  2009-06-25
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 2型糖尿病の病態と治療2009
- Author(s)
  金藤秀明
- Organizer
  藤井寺市医師会学術講演会
- Place of Presentation
  大阪
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 2型糖尿病の病態と治療2009
- Author(s)
  金藤秀明
- Organizer
  丹波市医師会学術講演会
- Place of Presentation
  丹波篠山
- Year and Date
  2009-07-16
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 膵β細胞ブドウ糖毒性の分子機構-酸化ストレスおよびインクレチンを中心に-2009
- Author(s)
  金藤秀明
- Organizer
  Incretin Active Meeting
- Place of Presentation
  札幌
- Year and Date
  2009-10-16
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 膵β細胞ブドウ糖毒性の分子機構2009
- Author(s)
  金藤秀明
- Organizer
  第13回病態代謝・血管医学セミナー
- Place of Presentation
  熊本
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 2型糖尿病の病態と治療2009
- Author(s)
  金藤秀明
- Organizer
  大阪狭山糖尿病談話会
- Place of Presentation
  大阪
- Year and Date
  2009-11-12
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 酸化ストレスによる膵β細胞機能障害2009
- Author(s)
  金藤秀明
- Organizer
  座談会膵島機能不全の病態と今後の治療展望
- Place of Presentation
  東京
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21591135
[Presentation] 膵における転写因子PDX-1の重要性2009
- Author(s)
  金藤秀明
- Organizer
  Meet the Expert Conference
- Place of Presentation
  大阪
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-21591135

1. MATUOKA Takaaki (10379258)

# of Collaborated Projects: 6 results

# of Collaborated Products: 23 results
2. MATSUHISA Munehide (60362737)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
3. 小畑淳史 (10771298)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
4. 木村友彦 (50454830)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
5. 下田将司 (60388957)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
6. KATAKAMI Naoto (10403049)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
7. YASUDA Tetsuyuki (30448055)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. MIYATSUKA Takeshi (60622363)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
9. Fujita Shunichi (30722607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 向井知之 (00454421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 内田治仁 (00550857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 守田吉孝 (50346441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 片倉幸乃 (40858247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 真田淳平 (70771301)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HIRUKAWA Hidenori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. OKAUCHI Seizo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 加来浩平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kaneto Hideaki 金藤 秀明

KANETO Hideaki 金藤 秀明

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ブドウ糖毒性が膵ラ氏島のm6A RNAメチル化不全に与える影響

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膵β細胞ブドウ糖毒性から見た新規糖尿病治療薬の探索Principal Investigator

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Pathophysiological analysis of vascular calcification

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Comprehensive searching for compounds which can directly enhance MafA and/or PDX-1 expressionPrincipal Investigator

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Investigation of novel diabetic medicine based on glucose toxicityPrincipal Investigator

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Development of non-invasive risk stratification systems for diabetic macroangiopathy

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Molecular mechanism for pancreatic beta-cell glucose toxicityPrincipal Investigator

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Analysis for new target gene of Mafa, and application for pancreatic beta-cell generation.

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Evaluation of the effects of the accumulation of gene polymorphismsrelated to oxidative stress on diabetic macroangiopathy

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Evaluation for significant role of Mafa under Type2 diabetic conditions

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Molecular mechanism for pancreatic beta-cell glucose toxicityPrincipal Investigator

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[Book] 「インスリン療法とインクレチン注射療法の差別化」Diabetes in the News2011

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[Book] 「インクレチンの膵β細胞保護・増殖作用」日本臨床特集インクレチン関連薬2011

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[Book] 「DPP-4阻害薬」月刊糖尿病別冊糖尿病治療薬ハンドブック2011

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Kaneto Hideaki 金藤秀明

KANETO Hideaki 金藤秀明