WATARI AKIHIRO 渡利彰浩

… Alternative Names

WATARI Akihiro 渡利彰浩

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Researcher Number	80452465
Other IDs
Affiliation (Current)	2025: 大阪大学, 医学部附属病院, 特任准教授(常勤)
Affiliation (based on the past Project Information) *help	2017: 大阪大学, 薬学研究科, 講師 2016: 大阪大学, 薬学研究科, 助教 2012 – 2015: 大阪大学, 薬学研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Medical pharmacy / Drug development chemistry Except Principal Investigator Medical pharmacy
Keywords	Principal Investigator クローディン / claudin / 細胞・組織 / 生体分子 / 医療・福祉 / 薬学 / TR-FRET / スクリーニング / バイオ医薬品 / Tight junction … More / 吸収促進 / rebeccamycin / daunorubicin / 上皮バリア / 炎症性腸疾患 / タイトジャンクション / クローディン発現 / 炎症性腸疾患治療法 / 上皮バリア機能制御 / 免疫学 / DDS / ワクチン … More Except Principal Investigator DDS / 薬学 / 表皮バリア / Tight junction / Tight junciton / Homoharringtonin / Claudin / Tight Junciton / Homoharringtonine / 表皮 / 経皮吸収 Less

バイオ医薬品の非侵襲性投与を可能とする次世代型TJ binderの開発Principal Investigator
- Principal Investigator
  
  渡利彰浩
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Osaka University
Development of transdermal penetration enhancer by regulating epidermal tight junction barriers
- Principal Investigator
  
  Yagi Kiyohito
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Osaka University
Development of inflammatory bowel disease treatment by restoration of intestinal epithelial barrier functionsPrincipal Investigator
- Principal Investigator
  
  Akihiro Watari
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University
Development of novel claudin-4 binder and its application in oral vaccinePrincipal Investigator
- Principal Investigator
  
  WATARI Akihiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Osaka University

All 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Book Patent

[Book] Tight junction modulatorを用いたペプチド医薬品の経粘膜吸収促進法2017
- Author(s)
  渡利彰浩, 八木清仁, 近藤昌夫
- Total Pages
  9
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-16K08370
[Book] タイトジャンクションバリア制御によるバイオ医薬品の吸収促進技術開発に向けて2017
- Author(s)
  渡利彰浩
- Total Pages
  2
- Publisher
  Drug Delivery System
- Data Source
  KAKENHI-PROJECT-16K08370
[Journal Article] Pancreatic adenocarcinoma upregulated factor has oncogenic functions in oral squamous cell carcinoma2018
- Author(s)
  Sasahira T, Kurihara M, Nishiguchi Y, Nakashima C, Kirita T, Kuniyasu H.
- Journal Title
  
  Histopathol
  
  Volume: 70 Pages: 539-548
- DOI
  10.1016/j.ejps.2018.02.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05164, KAKENHI-PROJECT-16K08370, KAKENHI-PROJECT-17K19923, KAKENHI-PROJECT-17K19487, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17J03990
[Journal Article] Identification of claudin-4 binder that attenuates tight junction barrier function by TR-FRET-based screening assay2017
- Author(s)
  Watari Akihiro、Kodaka Miki、Matsuhisa Koji、Sakamoto Yuta、Hisaie Kota、Kawashita Norihito、Takagi Tatsuya、Yamagishi Yoshiaki、Suzuki Hidehiko、Tsujino Hirofumi、Yagi Kiyohito、Kondoh Masuo
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 14514-14514
- DOI
  10.1038/s41598-017-15108-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08370
[Journal Article] Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model2017
- Author(s)
  Hashimoto Yosuke、Shirakura Keisuke、Okada Yoshiaki、Takeda Hiroyuki、Endo Kohki、Tamura Maki、Watari Akihiro、Sadamura Yoshifusa、Sawasaki Tatsuya、Doi Takefumi、Yagi Kiyohito、Kondoh Masuo
- Journal Title
  
  J Pharmacol Exp Ther.
  
  Volume: 363 Issue: 2 Pages: 275-283
- DOI
  10.1124/jpet.117.243014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19487, KAKENHI-PLANNED-16H06579, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-16K08370, KAKENHI-PROJECT-17J03990
[Journal Article] Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction.2017
- Author(s)
  Krug SM, Hayaishi T, Iguchi D, Watari A,Takahashi A, Fromm M, Nagahama M, Takeda H, Okada Y,Sawasaki T, Doi T, Yagi K, Kondoh M
- Journal Title
  
  J. Control. Release.
  
  Volume: 260 Pages: 1-11
- DOI
  10.1016/j.jconrel.2017.05.024
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08794, KAKENHI-PROJECT-17K19487, KAKENHI-PLANNED-16H06579, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-16K08370
[Journal Article] Lignosulfonic acid attenuates NF-κB activation and intestinal epithelial barrier dysfunction induced by TNF-α/IFN-γ in Caco-2 cells2017
- Author(s)
  Matsuhisa Koji、Watari Akihiro、Iwamoto Kazuki、Kondoh Masuo、Yagi Kiyohito
- Journal Title
  
  J Nat Med
  
  Volume: 72 Issue: 2 Pages: 448-455
- DOI
  10.1007/s11418-017-1167-5
- NAID
  40021511333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08370
[Journal Article] Rebeccamycin attenuates TNF-α-induced intestinal epithelial barrier dysfunction by inhibiting myosin light chain kinase production2017
- Author(s)
  Watari A., Sakamoto Y., Hisaie K., Iwamoto K., Fueta M., Yagi K., Kondoh M.
- Journal Title
  
  Cellular Physiology and Biochemistry
  
  Volume: -
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08370
[Journal Article] Creation of a Claudin-2 Binder and Its Tight Junction?Modulating Activity in a Human Intestinal Model2017
- Author(s)
  Takigawa Mutsumi、Iida Manami、Nagase Shotaro、Suzuki Hidehiko、Watari Akihiro、Tada Minoru、Okada Yoshiaki、Doi Takefumi、Fukasawa Masayoshi、Yagi Kiyohito、Kunisawa Jun、Kondoh Masuo
- Journal Title
  
  J Pharmacol Exp Ther.
  
  Volume: 363 Issue: 3 Pages: 444-451
- DOI
  10.1124/jpet.117.242214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19487, KAKENHI-PROJECT-26293111, KAKENHI-PROJECT-16K08370
[Journal Article] Dodecylmaltoside Modulates Bicellular Tight Junction Contacts To Promote Enhanced Permeability2017
- Author(s)
  Gradauer K.、Iida M.、Watari A.、Kataoka M.、Yamashita S.、Kondoh M.、Buckley S. T.
- Journal Title
  
  Mol Pharm
  
  Volume: 14 Issue: 12 Pages: 4734-4740
- DOI
  10.1021/acs.molpharmaceut.7b00297
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08370
[Journal Article] Checkpoint Kinase 1 Activation Enhances Intestinal Epithelial Barrier Function via Regulation of Claudin-5 Expression2016
- Author(s)
  Watari A., Hasegawa M., Yagi K., Kondoh M.
- Journal Title
  
  PLoS One
  
  Volume: 11 (1) Issue: 1 Pages: e0145631-e0145631
- DOI
  10.1371/journal.pone.0145631
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860078
[Journal Article] Generation and characterization of a human-mouse chimeric antibody against the extracellular domain of claudin-1 for cancer therapy using a mouse model.2016
- Author(s)
  Hashimoto Y, Tada M, Iida M, Nagase S, Hata T, Watari A, Okada Y, Doi T, Fukasawa M, Yagi K, Kondoh M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 477(1) Issue: 1 Pages: 91-95
- DOI
  10.1016/j.bbrc.2016.06.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293014, KAKENHI-PROJECT-16K08370, KAKENHI-PROJECT-15J10065
[Journal Article] Efficacy and safety evaluation of claudin-4-targeted antitumor therapy using a human and mouse cross-reactive monoclonal antibody2016
- Author(s)
  Hashimoto Y., Kawahigashi Y., Hata T., Li X., Watari A., Tada M., Ishii-Watabe A., Okada Y., Doi T., Fukasawa M., Kuniyasu H., Yagi K., Kondoh M
- Journal Title
  
  Pharmacology Research & Perspectives
  
  Volume: 4(5)
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08370
[Journal Article] Claudin-1 Binder Enhances Epidermal Permeability in a Human Keratinocyte Model2015
- Author(s)
  Nakajima M, Nagase S, Iida M, Takeda S, Yamashita M, Watari A, Shirasago Y, Fukasawa M, Takeda H, Sawasaki T, Yagi K, Kondoh M
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 354 Issue: 3 Pages: 440-447
- DOI
  10.1124/jpet.115.225391
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26750365, KAKENHI-PROJECT-26860078
[Journal Article] C-terminal Clostridium perfringens enterotoxin-mediated antigen delivery for nasal pneumococcal vaccine2015
- Author(s)
  H. Suzuki, A. Watari, E. Hashimoto, M. Yonemitsu, H. Kiyono, K. Yagi, M. Kondoh, and J. Kunisawa
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 5 Pages: e0126352-e0126352
- DOI
  10.1371/journal.pone.0126352
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18950, KAKENHI-PROJECT-26860078, KAKENHI-PROJECT-26293111
[Journal Article] Use of cell-based screening to identify small-molecule compounds that modulate claudin-4 expression2015
- Author(s)
  Watari A., Hashegawa M., Muangman T., Yagi K., Kondoh M.
- Journal Title
  
  Biotechnology Letters
  
  Volume: 37(6) Issue: 6 Pages: 1177-85
- DOI
  10.1007/s10529-015-1791-7
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860078
[Journal Article] Discovery of anti-claudin-1 antibodies as candidate therapeutics against hepatitis C virus2015
- Author(s)
  Mayo Yamashita, Manami Iida, Minoru Tada, Yohitaka Shirasago, Masayoshi Fukasawa, Shotaro Nagase, Akihiro Watari, Akiko Ishii-Watabe, Kiyohito Yagi, Masuo Kondoh
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 353 Issue: 1 Pages: 112-118
- DOI
  10.1124/jpet.114.217653
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390042, KAKENHI-PROJECT-26860078
[Journal Article] Anti-HCV effect of mycelia solid culture extracts of Lentinula edodes and low-molecular-weight lignin2015
- Author(s)
  Matsuhisa K., Yamane S., Okamoto T., Watari A., Kondoh M., Matsuura Y., Yagi K.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 462(1) Issue: 1 Pages: 52-7
- DOI
  10.1016/j.bbrc.2015.04.104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860078
[Journal Article] Homoharringtonine increases intestinal epithelial permeability by modulating specific claudin isoforms in Caco-2 cell monolayers2015
- Author(s)
  Akihiro Watari, Maki Hasegawa, Kiyohito Yagi, Masuo Kondoh
- Journal Title
  
  Eur J Pharm Biopharm
  
  Volume: 89 Pages: 232-238
- DOI
  10.1016/j.ejpb.2014.12.012
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390042, KAKENHI-PROJECT-26860078
[Journal Article] Development of an anti-claudin-3 and -4 bispecific monoclonal antibody for cancer diagnosis and therapy2014
- Author(s)
  Xiangru Li, Manami Iida, Minoru Tada, Akihiro Watari, Yumi Kawahigashi, Yuka Kimura, Taku Yamashita, Akiko Ishii-Watabe, Tadayuki Uno, Masayoshi Fukasawa, Hiroki Kuniyasu, Kiyohito Yagi, Masuo Kondoh
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 351 Issue: 1 Pages: 206-213
- DOI
  10.1124/jpet.114.216911
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390042, KAKENHI-PROJECT-25670177, KAKENHI-PROJECT-26860078
[Journal Article] Tissue distribution and safety evaluation of a claudin-targeting molecule, the C-terminal fragment of Clostridium perfringens enterotoxin2014
- Author(s)
  Xiangru Li, Rie Saeki, Akihiro Watari, Kiyohito Yagi, Masuo Kondoh
- Journal Title
  
  Tissue distribution and safety evaluation of a claudin-targeting molecule, the C-terminal fragment of Clostridium perfringens enterotoxin
  
  Volume: 52 Pages: 132-137
- DOI
  10.1016/j.ejps.2013.10.018
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390042, KAKENHI-PROJECT-24790155
[Journal Article] Tissue distribution and safety evaluation of a claudin-targeting molecule, the C-terminal fragment of Clostridium perfringens enterotoxin2014
- Author(s)
  Li X., Saeki R., Watari A., Yagi K., Kondoh M
- Journal Title
  
  Eur J Pharm Sci
  
  Volume: 52 Pages: 132-7
- Data Source
  KAKENHI-PROJECT-24790155
[Journal Article] A baculoviral display system to assay viral entry.2013
- Author(s)
  Iida M., Yoshida T., Watari A., Yagi K., Hamakubo T., Kondoh M.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 36(11) Pages: 1867-9
- NAID
  130003382052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790155
[Journal Article] Acute and chronic nephrotoxicity of platinum nanoparticles in mice.2013
- Author(s)
  Yamagishi Y, Watari A, Hayata Y, Li X, Kondoh M, Yoshioka Y, Tsutsumi Y, Yagi K.
- Journal Title
  
  Nanoscale Res. Lett.
  
  Volume: 8 Issue: 1 Pages: 395-395
- DOI
  10.1186/1556-276x-8-395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790155
[Journal Article] Hepatotoxicity of sub-nanosized platinum particles in mice2013
- Author(s)
  Yamagishi Y., Watari A., Hayata Y., Li X., Kondoh M., Tsutsumi Y., Yagi K
- Journal Title
  
  Pharmazie
  
  Volume: 69(3) Pages: 179-82
- Data Source
  KAKENHI-PROJECT-24790155
[Journal Article] A baculoviral display system to assay viral entry2013
- Author(s)
  I ida M., Yoshida T., Watari A., Yagi K., Hamakubo T., Kondoh M
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 36(11) Pages: 1867-9
- NAID
  130003382052
- Data Source
  KAKENHI-PROJECT-24790155
[Journal Article] Acute and chronic nephrotoxicity of platinum nanoparticles in mice2013
- Author(s)
  Yamagishi Y., Watari A., Hayata Y., Li X., Kondoh M., Yoshioka Y., Tsutsumi Y., Yagi K
- Journal Title
  
  Nanoscale Res Lett
  
  Volume: 8(1) Pages: 395-395
- Data Source
  KAKENHI-PROJECT-24790155
[Journal Article] Involvement of NANOG upregulation in malignant progression of human cells2013
- Author(s)
  Li Y., Higashiyama S., Shimakage M., Kawahara K., Yutsudo M., Watari A
- Journal Title
  
  DNA Cell Biol
  
  Volume: 32(3) Pages: 104-10
- Data Source
  KAKENHI-PROJECT-24790155
[Journal Article] Involvement of NANOG upregulation in malignant progression of human cells.2013
- Author(s)
  Li Y., Higashiyama S., Shimakage M., Kawahara K., Yutsudo M., Watari A.
- Journal Title
  
  DNA Cell Biol.
  
  Volume: 32(3) Issue: 3 Pages: 104-10
- DOI
  10.1089/dna.2012.1908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790155, KAKENHI-PUBLICLY-23112513
[Journal Article] Hepatotoxicity of sub-nanosized platinum particles in mice.2013
- Author(s)
  Yamagishi Y., Watari A., Hayata Y., Li X., Kondoh M., Tsutsumi Y., Yagi K.
- Journal Title
  
  Pharmazie
  
  Volume: 68(3) Pages: 178-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790155
[Journal Article] A novel proapoptotic gene PANO encodes a post-translational modulator of the tumor suppressor p14ARF2012
- Author(s)
  Watari A., Li Y., Higashiyama S., Yutsudo M.
- Journal Title
  
  Exp. Cell Res.
  
  Volume: 318 Issue: 3 Pages: 187-195
- DOI
  10.1016/j.yexcr.2011.10.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790155
[Journal Article] A novel proapoptotic gene PANO encodes a post-translational modulator of the tumor suppressor p14ARF2012
- Author(s)
  Watari A., Li Y., Higashiyama S., Yutsudo M
- Journal Title
  
  Exp Cell Res
  
  Volume: 18(3) Pages: 187-95
- Data Source
  KAKENHI-PROJECT-24790155
[Journal Article] Pathological changes in tight junctions and potential applications into therapies2012
- Author(s)
  Takahashi A., Kondoh M., Suzuki H., Watari A. and Yagi K.
- Journal Title
  
  Drug Discov. Today
  
  Volume: 17(13-14) Pages: 727-32
- Data Source
  KAKENHI-PROJECT-24790155
[Journal Article] Pathological changes in tight junctions and potential applications into therapies.2012
- Author(s)
  Takahashi A, Kondoh M, Suzuki H, Watari A, Yagi K.
- Journal Title
  
  Drug Discov Today.
  
  Volume: 13-14 Issue: 13-14 Pages: 727-732
- DOI
  10.1016/j.drudis.2012.02.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790155
[Journal Article] Nature of cancer explored from the perspective of the functional evolution of proto-oncogenes2012
- Author(s)
  Watari A.
- Journal Title
  
  Yakugaku Zasshi
  
  Volume: 132(10) Pages: 1165-70
- NAID
  130001871975
- Data Source
  KAKENHI-PROJECT-24790155
[Journal Article] A simple reporter assay for screening claudin-4 modulators2012
- Author(s)
  Watari A., Yagi K., Kondoh M.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 426 Issue: 4 Pages: 454-460
- DOI
  10.1016/j.bbrc.2012.08.083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790155
[Journal Article] A simple reporter assay for screening claudin-4 modulators2012
- Author(s)
  Watari A., Yagi K., Kondoh M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 426(4) Pages: 454-60
- Data Source
  KAKENHI-PROJECT-24790155
[Patent] 経皮吸収促進剤2017
- Inventor(s)
  渡利彰浩、八木清仁、近藤昌夫、横田隆徳、永田哲也
- Industrial Property Rights Holder
  国立大学法人大阪大学/国立大学法人東京医科歯科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-014957
- Filing Date
  2017-01-31
- Data Source
  KAKENHI-PROJECT-16K15161
[Patent] 核酸を含む経腸投与用組成物2016
- Inventor(s)
  八木清仁、近藤昌夫、渡利彰浩等
- Industrial Property Rights Holder
  八木清仁、近藤昌夫、渡利彰浩等
- Industrial Property Rights Type
  特許
- Filing Date
  2016-11-30
- Overseas
- Data Source
  KAKENHI-PROJECT-16K08370
[Patent] 抗体、フラグメント及び抗HCV治療剤2013
- Inventor(s)
  近藤昌夫、深澤征義、石井明子、多田稔、八木清仁、渡利彰浩
- Industrial Property Rights Holder
  近藤昌夫、深澤征義、石井明子、多田稔、八木清仁、渡利彰浩
- Industrial Property Rights Type
  特許
- Filing Date
  2013-02-28
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] タイトジャンクション構成因子を標的とした創薬基盤研究2017
- Author(s)
  渡利彰浩、八木清仁、近藤昌夫
- Organizer
  阪大薬―医薬基盤健栄研ランチミーティング
- Invited
- Data Source
  KAKENHI-PROJECT-16K08370
[Presentation] Time-Resolved Fluorescence Resonance Energy Transfer-based Screen for Identification of Novel Claudin-4 binders that Modulate the Epithelial Tight Junction Barrier2017
- Author(s)
  A. Watari, Y. Sakamoto, K. Hisaie, K. Yagi, M. Kondoh
- Organizer
  The 2017 AAPS Annual Meeting and Exposition programming
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08370
[Presentation] TR-FRETによる低分子 CLDN-4 binder スクリーニング系の構築2017
- Author(s)
  坂本雄太、渡利彰浩、小高美樹、久家広大、八木清仁、近藤昌夫
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08370
[Presentation] Use of a Time-Resolved Fluorescence Resonance Energy Transfer-based screening assay to identify a claudin-4 binder that attenuates tight junction barrier function.2017
- Author(s)
  A. Watari, K. Yagi, M. Kondoh
- Organizer
  ASCB/EMBO 2017 meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08370
[Presentation] Homoharringtonine enhances transdermal absorption in the skin by regulating epidermal tight junction barriers2017
- Author(s)
  K. Yagi, A. Watari, K. Fujiwara, N. Suzuki, M. Kondoh
- Organizer
  ASCB/EMBO 2017 meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15161
[Presentation] Homoharringtonineによる経皮吸収促進効果の検討2017
- Author(s)
  渡利彰浩、藤原果奈、倉智彩夢、近藤昌夫、八木清仁
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08370
[Presentation] DNA damageが誘導する腸管上皮バリアの機能亢進2017
- Author(s)
  渡利彰浩、長谷川真希、八木清仁、近藤昌夫
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08370
[Presentation] Development of Homoharringtonine as a Penetration Enhancer for Transdermal Drug Administration2017
- Author(s)
  K. Yagi, A. Watari, k. Fujiwara, T. kurachi, N. Suzuki, M. Kondoh
- Organizer
  The 2017 AAPS Annual Meeting and Exposition programming
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08370
[Presentation] Homoharringtonineによる核酸医薬の経皮投与基盤技術の開発2017
- Author(s)
  2.藤原果奈、渡利彰浩、永田哲也、近藤昌夫、横田隆徳、八木清仁
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K15161
[Presentation] Development of Homoharringtonine as a Penetration Enhancer for Transdermal Drug Administration2017
- Author(s)
  K. Yagi, A. Watari, k. Fujiwara, T. kurachi, N. Suzuki, M. Kondoh
- Organizer
  The 2017 AAPS Annual Meeting and Exposition programming
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15161
[Presentation] Use of a Time-Resolved Fluorescence Resonance Energy Transfer-based screen to identify a novel claudin-4 binding compound that attenuates the tight junction barrier2017
- Author(s)
  A. Watari, K. Yagi, M. Kondoh
- Organizer
  6th FIP Pharmaceutical Sciences World Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08370
[Presentation] Homoharringtonine enhances transdermal absorption in the skin by regulating epidermal tight junction barriers.2017
- Author(s)
  K. Yagi, A. Watari, K. Fujiwara, N. Suzuki, M. Kondoh
- Organizer
  ASCB/EMBO 2017 meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08370
[Presentation] Homoharringtonineによる核酸医薬の経皮投与基盤技術の開発2017
- Author(s)
  藤原果奈、渡利彰浩、永田哲也、近藤昌夫、横田隆徳、八木清仁
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08370
[Presentation] Time-resolved fluorescence resonance energy transfer法により同定した低分子claudin-4 binderの機能解析2017
- Author(s)
  坂本雄太、渡利彰浩、小高美樹、久家広大、八木清仁、近藤昌夫
- Organizer
  第40回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-16K08370
[Presentation] Homoharringtonineによる経皮吸収促進効果の検討2017
- Author(s)
  渡利彰浩、藤原果奈、倉智彩夢、近藤昌夫、八木清仁
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15161
[Presentation] Tight junction binderによる上皮バリア制御時における遺伝子発現変動の解析2016
- Author(s)
  関昌孝、井口大輔、早石知浩、吉田有裕美、渡利彰浩、近藤昌夫、八木清仁
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26860078
[Presentation] Claudinを標的とした創薬基盤技術の開発～claudin-4を標的としたがん治療戦略の有効性及び安全性の評価～2016
- Author(s)
  松田基、橋本洋佑、川東祐美、畑智幸、渡利彰浩、近藤昌夫、岡田欣晃、土井健史、八木清仁、多田稔、石井明子、深澤征義
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26860078
[Presentation] Tricellular tight junctionを標的とした新規バリア制御技術、angubindin-1の開発2016
- Author(s)
  山本浩樹、井口大輔、早石知浩、Susanne M. Krug、Michael Fromm、渡利彰浩、岡田欣晃、竹田浩之、永浜政博、土井健史、澤崎達也、近藤昌夫、八木清仁
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26860078
[Presentation] Tight junction binderによる核酸医薬の経口投与法開発に関する基盤研究2016
- Author(s)
  渡利彰浩、藤原果奈、渡辺知恵、仁科一隆、永田哲也、近藤昌夫、横田隆徳、村上正裕、八木清仁
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26860078
[Presentation] Safety profile and anti-tumor activity of a new generated human/mouse cross-reactive Anti-claudin-4 monoclonal antibody in mice2015
- Author(s)
  Y. Hashimoto, Y. Kawahigashi, T. Hata, Y. Kimura, A. Watari, M. Kondoh, K. Yagi
- Organizer
  European Cancer Congress 2015
- Place of Presentation
  Vienna, Austria
- Year and Date
  2015-09-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860078
[Presentation] Tricellular tight junction binder,angubindin-1の創製とバリア制御活性解析2015
- Author(s)
  井口大輔、早石知浩、Susanne M. Krug、竹田浩之、Michael Fromm、渡利彰浩、澤崎達也、八木清仁、近藤昌夫
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-26860078
[Presentation] Claudin-1を標的とした経皮吸収促進の可能性2015
- Author(s)
  中嶋美咲、山下真代、渡利彰浩、深澤征義、八木清仁、近藤昌夫
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-26860078
[Presentation] Development of a novel strategy for the enhancement of drug absorption tarageting Claudin2014
- Author(s)
  M. Iida, H. Suzuki, X. Li, A. Watari, M. Kondoh, and K. Yagi
- Organizer
  第12回　プロテイン・アイランド　松山国際学術シンポジウム
- Place of Presentation
  愛媛県、松山市
- Year and Date
  2014-09-17
- Data Source
  KAKENHI-PROJECT-26860078
[Presentation] Claudin-3 and -4 binderの体内動態解析および安全性評価2013
- Author(s)
  李　相儒、近藤昌夫、渡利彰浩、八木清仁
- Organizer
  第32回分子病理研究会
- Place of Presentation
  奈良県吉野町
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Claudinを標的とした粘膜ワクチン技術の開発2013
- Author(s)
  土山　遼、鈴木英彦、角谷英樹、渡利彰浩、近藤昌夫、八木清仁
- Organizer
  第32回分子病理研究会
- Place of Presentation
  奈良県吉野町
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Claudin-3 and -4 binderの体内動態解析および安全性評価2013
- Author(s)
  李相儒、近藤昌夫、渡利彰浩、八木清仁
- Organizer
  第32回分子病理研究会
- Place of Presentation
  奈良県,吉野町
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] An improved claudin-targeting mucosal vaccine using a double alanine-substituted Mutant of the C-terminal fragment of Clostridium perfringens enterotoxin2013
- Author(s)
  Suzuki H., Kunisawa J., Watari A., Yamashita M., Yagi K., Kondoh M
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society 2013
- Place of Presentation
  Honolulu, HI, U.S.A.
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] タイトジャンクションを標的とした創薬基盤研究2013
- Author(s)
  渡利彰浩、近藤昌夫、八木清仁
- Organizer
  第19回　ハインドガットクラブジャパンシンポジウム
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Identification of chemical compounds that modulate claudin-4 expression by cell-based screening2013
- Author(s)
  Watari A., Hasegawa M., Yagi K., Kondoh M
- Organizer
  The American society for Cell Biology
- Place of Presentation
  New Orleans, U.S.A
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Tissue-distribution and safety evaluation of a claudin-3/4 binder in mice2013
- Author(s)
  Li X., Watari A., Yagi K., Kondoh M
- Organizer
  The American society for Cell Biology
- Place of Presentation
  New Orleans, U.S.A.
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Tissue-distribution and safety evaluation of a claudin-3/4 binder in mice.2013
- Author(s)
  X. Li, A. Watari, K. Yagi, M. Kondoh.
- Organizer
  The American society for Cell Biology
- Place of Presentation
  New Orleans, U.S.A.
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Creation of a broadly specific claudin binder and its absorption-enhancing actibity.2013
- Author(s)
  R. Doyama, K. Matsuhisa, A. Takahashi, K. Matsuhisa, A. Watari, T. Hamakubo, K. Yagi, M. Kondoh.
- Organizer
  2013 AAPS Annual Meeting and Exposition
- Place of Presentation
  San Antonio, U.S.A.
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Creation of a broadly specific claudin binder and its absorption-enhancing actibity2013
- Author(s)
  Doyama R., Matsuhisa K., Takahashi A., Matsuhisa K., Watari A., Hamakubo T., Yagi K., Kondoh M
- Organizer
  2013 AAPS Annual Meeting and Exposition
- Place of Presentation
  San Antonio, U.S.A.
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Identification of chemical compounds that modulate claudin-4 expression by cell-based screening.2013
- Author(s)
  A. Watari, M. Hasegawa, K. Yagi, M. Kondoh.
- Organizer
  The American society for Cell Biology
- Place of Presentation
  New Orleans, U.S.A.
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] An improved claudin-targeting mucosal vaccine using a double alanine-substituted mutant of the C-terminal fragment of Clostridium perfringens enterotoxin.2013
- Author(s)
  H. Suzuki, J. Kunisawa, A. Watari, M. Yamashita, K. Yagi, M. Kondoh.
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society 2013
- Place of Presentation
  Honolulu,HI, U.S.A.
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Claudinを標的とした粘膜ワクチン技術の開発2013
- Author(s)
  土山遼、鈴木英彦、角谷英樹、渡利彰浩、近藤昌夫、八木清仁
- Organizer
  第32回分子病理研究会
- Place of Presentation
  奈良県,吉野町
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Tissue-distribution of claudin-3/-4 binder, the C-terminal fragment of Clostridium perfringens enterotoxin, in mice2013
- Author(s)
  Li X., Kondoh M., Watari A. and Yagi K
- Organizer
  Experimental Biology 2013
- Place of Presentation
  Boston, U.S.A.
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Tissue-distribution of claudin-3/-4 binder, the C-terminal fragment of Clostridium perfringens enterotoxin, in mice.2013
- Author(s)
  X. Li, M. Kondoh, A. Watari and K. Yagi.
- Organizer
  Experimental Biology 2013
- Place of Presentation
  Boston, U.S.A.
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] タイトジャンクションを標的とした創薬基盤研究2013
- Author(s)
  8.渡利彰浩、近藤昌夫、八木清仁
- Organizer
  第19回ハインガットクラブジャパンシンポジウム
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Clostridium perfringens enterotoxin断片を利用したclaudin指向性吸収促進技術の安全性評価2012
- Author(s)
  土山亮、長瀬翔太郎、鈴木英彦、李相儒、山根誠司、渡利彰浩、近藤昌夫、八木清仁
- Organizer
  第59回トキシンシンポジウム
- Place of Presentation
  北海道,帯広市
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Preparation of a broad-specific claudin binder by using Clotridium perfringens enterotoxin2012
- Author(s)
  Suzuki H., Takahashi A., Matsushita K., Li X., Tsujino H., Watari A., Kondoh M., Aoyama H., Uno T. and Yagi K
- Organizer
  Experimental Biology 2012
- Place of Presentation
  SanDiego, U.S.A.
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] 高親和性 claudin-4 binderの創製と粘膜ワクチンへの応用2012
- Author(s)
  鈴木英彦、山根誠司、角谷英樹、高橋　梓、内田博司、渡利彰浩、近藤昌夫、八木清仁
- Organizer
  第28回DDS学会学術集会
- Place of Presentation
  札幌市、北海道
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Biochemical analysis of a claudin ligand that exhibits a broad binding specificity2012
- Author(s)
  Doyama R., Suzuki H., Matsushita K., Li X, Takahashi A., Matsuhisa K., Tsujino H., Watari A., Kondoh M., Aoyama H., Uno T. and Yagi K
- Organizer
  Molecular Structure and Function of the Apical Junctional Complex in Epithelia and Endothelia
- Place of Presentation
  Merida, MEXICO
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] 原がん遺伝子の機能進化から探る新たながん化メカニズムの解析2012
- Author(s)
  渡利彰浩、岡田雅人、八木清仁
- Organizer
  第62回日本薬学会近畿支部総会・大会
- Place of Presentation
  西宮,兵庫県
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Establishment of a cell-based screening system for chemical modulators of claudin expression2012
- Author(s)
  Watari A., Hasegawa M., Kondoh M. and Yagi K., ., , Dec 1-4
- Organizer
  Molecular Structure and Function of the Apical Junctional Complex in Epithelia and Endothelia
- Place of Presentation
  Merida, MEXICO
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Evaluation of HCV infection and replication using human iPS cell-derived hepatocytes2012
- Author(s)
  Yagi K., Yoshida T., Yamane S., Takayama K., Watari A., Kondoh M., Sakurai F., Sakamoto N., Mtsuura Y., Mizuguchi H
- Organizer
  HCV2012 19th International Symposium on Hepatittis C virus and Relate viruses
- Place of Presentation
  Venice, ITALY
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Biochemical analysis of a claudin ligand that exhibits a broad binding specificity2012
- Author(s)
  Doyama R. ,Suzuki H., Matsushita K., Li X., Takahashi A., Matsuhisa K., Tsujino H., Watari A., Kondoh M. Aoyama H., Uno T. and Yagi K.
- Organizer
  Molecular Structure and Funcction of the Apical Junctional Comples in Epithelia and Endothelia
- Place of Presentation
  Merida,MEXICO
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] 高親和性claudin-4 binderの創製と粘膜ワクチンへの応用2012
- Author(s)
  鈴木英彦、山根誠司、角谷英樹、高橋梓、内田博司、渡利彰浩、近藤昌夫、八木清仁
- Organizer
  第28回DDS学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Establishment of a cell-based screening system for chemical modulators of claudin expression2012
- Author(s)
  Watari,A., Hasegawa M., Kondoh M. and Yagi K.
- Organizer
  Molecular Structure and Function of the Apical Junctional Cpmplex in Epithelia and Endothelia
- Place of Presentation
  Merida,MEXICO
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Clostridium perfringens enterotoxin断片を利用した claudin指向性吸収促進技術の安全性評価2012
- Author(s)
  土山亮、長瀬翔太郎、鈴木英彦、李相儒、山根誠司、渡利彰浩、近藤昌夫、八木清仁
- Organizer
  第59回トキシンシンポジウム
- Place of Presentation
  北海道、帯広市
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] 原がん遺伝子の機能進化から探る新たながん化メカニズムの解析2012
- Author(s)
  渡利彰浩、岡田雅人、八木清仁
- Organizer
  第62回日本薬学会近畿支部総会・大会
- Place of Presentation
  西宮市、兵庫県
- Invited
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] Preparation of a broad-specific claudin binder by using Clotridium perfringens enterotoxin2012
- Author(s)
  Hidehiko Suzuki, Azusa Takahashi, K.Matsushita, X.Li, H. Tsujino, Akihiro Watari, Masuo Kondoh, H.Aoyama, T. Uno and Kiyohito Yagi
- Organizer
  Experimental Biology
- Place of Presentation
  SanDiego, U.S.A
- Data Source
  KAKENHI-PROJECT-24790155
[Presentation] DNA damageが誘導する腸管上皮バリアの機能亢進
- Author(s)
  渡利　彰浩、長谷川　真希、八木　清仁、近藤　昌夫
- Organizer
  37回日本分子生物学会年会
- Place of Presentation
  神奈川県、横浜市
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26860078
[Presentation] Epitope mapping of an anti-claudin-1 monoclonal antibody and its application to preclinical drug discovery.
- Author(s)
  T. Hata, S. Nagase, Y. Shirasago, M. Fukasawa, A. Watari, K. Yagi, M. Kondoh
- Organizer
  Antibody Engineering & Therapeutics 2014
- Place of Presentation
  Huntington Beach, CA, U.S.A.
- Year and Date
  2014-12-07 – 2014-12-11
- Data Source
  KAKENHI-PROJECT-26860078
[Presentation] Anti-human claudin-1 monoclonal antbodies as anti-Hepatitis C Virus agents.
- Author(s)
  M. Iida, M. Yamashita, S. Nagase, M. Tada, Y. Shirasago, M. Fukasawa, A. Watari, A. Ishii-Watabe, K. Yagi, M. Kondoh
- Organizer
  Antibody Engineering & Therapeutics 2014
- Place of Presentation
  Huntington Beach, CA, U.S.A.
- Year and Date
  2014-12-07 – 2014-12-11
- Data Source
  KAKENHI-PROJECT-26860078
[Presentation] Development of an angulin binder and its tricellular tight junction-modulating activity
- Author(s)
  D. Iguchi, S. M. Krug, T. Hayaishi, A. Watari, M. Nagahama, M. Flomm, K. Yagi, M. Kondoh
- Organizer
  The 2014 ASCB / IFCB meeting
- Place of Presentation
  Pennsylvania, U.S.A.
- Year and Date
  2014-12-06 – 2014-12-10
- Data Source
  KAKENHI-PROJECT-26860078
[Presentation] Development of a Novel Bispecific Anti-Claudin Antibody and its Anti-Tumor Activity
- Author(s)
  Y. Kimura, X. Li, M. Iida, M. Tada, A. Watabe-Ishii, M. Fukasawa, Y. Kawahigashi, A. Watari, K. Yagi, M. Kondoh
- Organizer
  Antibody Engineering & Therapeutics 2014
- Place of Presentation
  Huntington Beach, CA, U.S.A.
- Year and Date
  2014-12-07 – 2014-12-11
- Data Source
  KAKENHI-PROJECT-26860078

1. Yagi Kiyohito (70166479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. OKADA Yoshiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. KONDOH masuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
4. TAKEDA hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 鈴木英彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 国安弘基

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 永浜政博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 土井健史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

WATARI AKIHIRO 渡利 彰浩

WATARI Akihiro 渡利 彰浩

Research Projects

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Co-Researchers

バイオ医薬品の非侵襲性投与を可能とする次世代型TJ binderの開発Principal Investigator

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Development of transdermal penetration enhancer by regulating epidermal tight junction barriers

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Development of inflammatory bowel disease treatment by restoration of intestinal epithelial barrier functionsPrincipal Investigator

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Development of novel claudin-4 binder and its application in oral vaccinePrincipal Investigator

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[Book] Tight junction modulatorを用いたペプチド医薬品の経粘膜吸収促進法2017

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[Book] タイトジャンクションバリア制御によるバイオ医薬品の吸収促進技術開発に向けて2017

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[Journal Article] Pancreatic adenocarcinoma upregulated factor has oncogenic functions in oral squamous cell carcinoma2018

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[Journal Article] Identification of claudin-4 binder that attenuates tight junction barrier function by TR-FRET-based screening assay2017

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[Journal Article] Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model2017

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[Journal Article] Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction.2017

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[Journal Article] Lignosulfonic acid attenuates NF-κB activation and intestinal epithelial barrier dysfunction induced by TNF-α/IFN-γ in Caco-2 cells2017

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NAID

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[Journal Article] Rebeccamycin attenuates TNF-α-induced intestinal epithelial barrier dysfunction by inhibiting myosin light chain kinase production2017

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[Journal Article] Creation of a Claudin-2 Binder and Its Tight Junction?Modulating Activity in a Human Intestinal Model2017

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[Journal Article] Dodecylmaltoside Modulates Bicellular Tight Junction Contacts To Promote Enhanced Permeability2017

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[Journal Article] Checkpoint Kinase 1 Activation Enhances Intestinal Epithelial Barrier Function via Regulation of Claudin-5 Expression2016

WATARI AKIHIRO 渡利彰浩

WATARI Akihiro 渡利彰浩