HARA Toshifumi 原敏文

… Alternative Names

Hara Toshifumi 原敏文

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Researcher Number	80456219
Other IDs
Affiliation (Current)	2025: 愛知学院大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2023: 愛知学院大学, 薬学部, 講師 2016 – 2020: 愛知学院大学, 薬学部, 助教 2015: 新潟大学, 医歯学系, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology / Tumor therapeutics
Keywords	Principal Investigator 癌転移 / RNA / 転移 / METTL27 / メチル基転移酵素 / スキルス胃癌 / 癌化 / 癌転移の分子機構 / がん転移 / メチル化 … More / RNA修飾 / 機能性RNA / 浸潤・転移 / スキルス胃がん / ノンコーディングRNA / 癌 / 合成致死 / microRNA / HTLV-1 / miRNA / ATL Less

スキルス胃癌の悪性化に伴い発現増加するMETTL27の機能解析Principal Investigator
- Principal Investigator
  
  原敏文
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Aichi Gakuin University
Analysis of RNA methylation in metastasis of human scirrhous gastric cancerPrincipal Investigator
- Principal Investigator
  
  Hara Toshifumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Aichi Gakuin University
Functional analysis of long non-coding RNAs associated with metastasis of human scirrhous gastric cancersPrincipal Investigator
- Principal Investigator
  
  Hara Toshifumi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Aichi Gakuin University
Identification of miRNAs inducing synthetic lethality in ATL cellsPrincipal Investigator
- Principal Investigator
  
  Hara Toshifumi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Aichi Gakuin University
  Niigata University

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Elevated METTL9 is associated with peritoneal dissemination in human scirrhous gastric cancers2022
- Author(s)
  ToshifumiHara, Yuuki Tominaga, Koji Ueda, Keichiro Mihara, KazuyoshiYanagihara, Yoshifumi Takei
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 30 Pages: 101255-101255
- DOI
  10.1016/j.bbrep.2022.101255
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07698, KAKENHI-PROJECT-22K07159, KAKENHI-PROJECT-23K24297
[Journal Article] Elevated Expression of CELSR1 is Associated with Peritoneal Metastasis in Human Scirrhous Gastric Cancers2021
- Author(s)
  Toshifumi Hara, Yuri Nomura, Masaaki Hattori, Keichiro Mihara, Kazuyoshi Yanagihara, Yoshifumi Takei
- Journal Title
  
  BPB Reports
  
  Volume: 4 Issue: 4 Pages: 103-111
- DOI
  10.1248/bpbreports.4.4_103
- NAID
  130008074323
- ISSN
  2434-432X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07698, KAKENHI-PROJECT-19H03149
[Journal Article] Promoter CpG methylation inhibits Kr?ppel-like factor 2 (KLF2)-Mediated repression of hTERT gene expression in human T-cells2021
- Author(s)
  Mizuguchi Mariko、Hara Toshifumi、Yoshita-Takahashi Manami、Kohda Takashi、Tanaka Yuetsu、Nakamura Masataka
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 26 Pages: 100984-100984
- DOI
  10.1016/j.bbrep.2021.100984
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07698, KAKENHI-PROJECT-19K08843
[Journal Article] Long Noncoding RNA HOTAIR Promotes Epithelial-Mesenchymal Transition and Is a Suitable Target to Inhibit Peritoneal Dissemination in Human Scirrhous Gastric Cancers2020
- Author(s)
  Takei Yoshifumi、Hara Toshifumi、Suzuki Akiko、Mihara Keichiro、Yanagihara Kazuyoshi
- Journal Title
  
  Pathobiology
  
  Volume: 87 Issue: 5 Pages: 277-290
- DOI
  10.1159/000508350
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07698, KAKENHI-PROJECT-19H03149
[Journal Article] USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells2019
- Author(s)
  Piatnitskaia S, Takahashi M, Kitaura H, Katsuragi Y, Kakihana T, Zhang L, Kakita A, Iwakura Y, Nawa H, Miura T, Ikeuchi T, Hara T, Fujii M
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 10591-10591
- DOI
  10.1038/s41598-019-47033-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07698, KAKENHI-PROJECT-19K17822, KAKENHI-PROJECT-19H03432, KAKENHI-PROJECT-19H03542, KAKENHI-PROJECT-16K09822, KAKENHI-PROJECT-17K07380, KAKENHI-PROJECT-17K09918
[Journal Article] MicroRNAs Associated with Epithelial-Mesenchymal Transition Can Be Targeted to Inhibit Peritoneal Dissemination of Human Scirrhous Gastric Cancers2018
- Author(s)
  Takei Y, Shen G, Morita-Kondo A, Hara T, Mihara K, Yanagihara K
- Journal Title
  
  Pathobiology
  
  Volume: 85 Issue: 4 Pages: 232-246
- DOI
  10.1159/000488801
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14989, KAKENHI-PROJECT-16H04697
[Journal Article] MAGI-1 expression is decreased in several types of human T-cell leukemia cell lines, including adult T-cell leukemia.2018
- Author(s)
  Kozakai T, Takahashi M, Higuchi M, Hara T, Saito K, Tanaka Y, Masuko M, Takizawa J, Sone H, Fujii M
- Journal Title
  
  International Journal of Hematology
  
  Volume: 107(3) Issue: 3 Pages: 337-344
- DOI
  10.1007/s12185-017-2359-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09868, KAKENHI-PROJECT-17K09918, KAKENHI-PROJECT-16K15502, KAKENHI-PROJECT-17K14989, KAKENHI-PROJECT-15H04704, KAKENHI-PROJECT-15K09469, KAKENHI-PROJECT-16K09822
[Journal Article] Induction of Cell Death by Human T-cell Leukemia Virus Type 1 Tax in a Cell Cycle-Dependent Manner.2016
- Author(s)
  Mizuguchi M, Sasaki Y, Hara T, Higuchi M, Tanaka Y, Funato N, Tanaka N, Fujii M, Nakamura M.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 2 Pages: 0148217-0148217
- DOI
  10.1371/journal.pone.0148217
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11004, KAKENHI-PROJECT-15K21003, KAKENHI-PROJECT-25670774, KAKENHI-PROJECT-26670222, KAKENHI-PROJECT-15H04704, KAKENHI-PROJECT-15K14414, KAKENHI-PROJECT-16K15502
[Journal Article] USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells.2016
- Author(s)
  Higuchi M, Kawamura H, Matsuki H, Hara T, Takahashi M, Saito S, Saito K, Jiang S, Naito M, Kiyonari H, Fujii M.
- Journal Title
  
  Stem Cell Reports
  
  Volume: ７ Issue: 6 Pages: 1116-1129
- DOI
  10.1016/j.stemcr.2016.11.003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04704, KAKENHI-PROJECT-26461417, KAKENHI-PROJECT-15K21003, KAKENHI-PROJECT-15K09469, KAKENHI-PROJECT-16K15502
[Journal Article] Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB.2016
- Author(s)
  Motai Y, Takahashi M, Takachi T, Higuchi M, Hara T, Mizuguchi M, Aoyagi Y, Terai S, Tanaka Y, Fujii M.
- Journal Title
  
  Virus Genes.
  
  Volume: 52 Issue: 1 Pages: 4-13
- DOI
  10.1007/s11262-015-1277-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461417, KAKENHI-PROJECT-15K21003, KAKENHI-PROJECT-26670222, KAKENHI-PROJECT-15H04704, KAKENHI-PROJECT-16K15502
[Journal Article] Kruppel-like factor 2 represses transcription of the telomerase catalytic subunit hTERT in human T cells.2015
- Author(s)
  Hara T, Mizuguchi M, Fujii M, Nakamura M.
- Journal Title
  
  J Biol Chem
  
  Volume: 290(14) Issue: 14 Pages: 8758-8763
- DOI
  10.1074/jbc.m114.610386
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K21003, KAKENHI-PROJECT-15H04704
[Presentation] Alteration of methyltransferase-like (METTL) genes expression and its functional relevance to peritoneal dissemination in human scirrhous gastric cancers2022
- Author(s)
  Toshifumi Hara, Kazuyoshi Yanagihara, Yoshifumi Takei
- Organizer
  EMBL symposium 2022 The complex life of RNA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07159
[Presentation] The importance of methyltransferase like (METTL) genes on metastatic property in human scirrhous gastric cancer2021
- Author(s)
  Toshifumi Hara, KazuyoshiYanagihara, Yoshifumi Takei
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07698
[Presentation] Galectin 4 の発現変化とスキルス胃癌の腹膜転移能の関係2021
- Author(s)
  森田あや美、岩砂浩樹、原敏文、武井佳史
- Organizer
  第67回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-19K07698
[Presentation] スキルス胃癌の腹膜転移で発現増加するCELSR1の役割2021
- Author(s)
  野村祐里、原敏文、森田あや美、武井佳史
- Organizer
  第67回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-19K07698
[Presentation] A novel signature gene associated with peritoneal dissemination of human scirrhous gastric cancer2020
- Author(s)
  Toshifumi Hara, Kazuyoshi Yanagihara, Yoshifumi Takei
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-19K07698
[Presentation] Comprehensive genome-wide gene expression profiling reveals novel signatures of peritoneal metastasis in human scirrhous gastric cancer2019
- Author(s)
  Toshifumi Hara, Kazuyoshi Yanagihara, Yoshifumi Takei
- Organizer
  11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14989
[Presentation] スキルス胃癌の腹膜転移において Galectin 4 が果たす役割の解明2019
- Author(s)
  浅野秀斗、森田あや美、原敏文、武井佳史
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K14989
[Presentation] 活性型ビタミンD3がスキルス胃癌の腹膜転移能に与える影響2019
- Author(s)
  森田あや美、須藤夕稀、原敏文、武井佳史
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K14989
[Presentation] Analysis of CELSR1 functions in peritoneal metastasis2019
- Author(s)
  原　敏文、柳原五吉、武井佳史
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07698
[Presentation] The hallmarks of long non-coding RNA associated with metastasis in human scirrhous gastric cancer2018
- Author(s)
  Toshifumi Hara, Kazuyoshi Yanagihara, Yoshifumi Takei
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K14989
[Presentation] スキルス胃がんの転移に伴い発現変動する長鎖非コードRNA(lncRNA)の同定とその機能解析2018
- Author(s)
  山口優紀、原敏文、森田あや美、武井佳史
- Organizer
  第64回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K14989
[Presentation] スキルス胃癌の腹膜転移に関わる遺伝子の機能解析2018
- Author(s)
  花井檀、原敏文、森田あや美、武井佳史
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K14989
[Presentation] スキルス胃がんの転移を標的とした化合物スクリーニング方法の確立と一次スクリーニングの結果2018
- Author(s)
  野村有紀、原敏文、森田あや美、小幡徹、田中基裕、武井佳史
- Organizer
  第64回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K14989
[Presentation] スキルス胃癌の腹膜転移機構の解明に関する研究2018
- Author(s)
  服部真晃　原敏文　森田あや美　武井佳史
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K14989
[Presentation] スキルス胃癌の転移に伴い発現変動する遺伝子シグネチャーの同定とそれら遺伝子の機能解析2018
- Author(s)
  原敏文、服部真晃、花井檀、森田あや美、武井佳史
- Organizer
  第82回日本生化学会中部支部例会
- Data Source
  KAKENHI-PROJECT-17K14989
[Presentation] スキルス胃がんの腹膜転移に伴って発現変動するlncRNAの同定とその機能解析2018
- Author(s)
  原敏文、柳原五吉、武井佳史
- Organizer
  第20回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-17K14989
[Presentation] Selective targeting of adult T-cell leukemia by miR-124-3p through repression of multiple genes essential for the survival of HTLV-I-infected cells2017
- Author(s)
  Toshifumi Hara, Masataka Nakamura, Masahiro Fujii
- Organizer
  The 43rd Naito Conference
- Data Source
  KAKENHI-PROJECT-17K14989
[Presentation] ヒトスキルス胃がんの網羅的転写解析による新たな転移シグネチャーの抽出2017
- Author(s)
  原敏文、柳原五吉、武井佳史
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K14989
[Presentation] スキルス胃癌患者由来のリンパ行性転移細胞株の樹立とその抗転移療法への応用2017
- Author(s)
  武井佳史、原敏文、落谷孝広、柳原五吉
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K14989
[Presentation] Identification of miRNAs inducing synthetic lethality in ATL cells2016
- Author(s)
  Hara T, Fujii M
- Organizer
  The 41st Naito Conference
- Place of Presentation
  CHATERAISE Gateaux Kingdom SAPPORO　（北海道・札幌市)
- Year and Date
  2016-07-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21003
[Presentation] Dynamic regulation of telomerase gene expression through the transcription factor KLF2 in human T cells.2016
- Author(s)
  Hara T, Mizuguchi M, Fujii M, Nakamura M.
- Organizer
  EMBL Symposia 2016 The Complex Life of mRNA
- Place of Presentation
  EMBL Heidelberg(ドイツ・ハイデルベルグ)
- Year and Date
  2016-10-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21003
[Presentation] DNA Methylation of the Human Telomerase Reverse Transcriptase (hTERT) Promoter in Human T-cell Leukemia Virus Type-1 (HTLV-1) Infected T-cells2016
- Author(s)
  Mizuguchi M, Hara T, Yoshita-Takahasi M, Tanaka Y, Fukushima T, Nakamura M.
- Organizer
  The 5th JCA-AACR Special Joint Conference
- Place of Presentation
  Tokyo Bay Maihama Hotel Club Resort (千葉県・浦安市)
- Year and Date
  2016-07-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21003
[Presentation] miR-126は変異型KRAS細胞を選択的に増殖抑制する2015
- Author(s)
  原　敏文、 Ashish Lal
- Organizer
  第17回日本RNA学会年会
- Place of Presentation
  ホテルライフォート札幌(北海道・札幌市)
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-15K21003
[Presentation] HTLV-1のTax1はHTLV-2のTax2とは異なる細胞遺伝子の発現をNF-kB2を介して誘導する2015
- Author(s)
  藤井雅寛、罇陽介、原敏文、樋口雅也、髙橋雅彦
- Organizer
  第2回日本HTLV-1学会学術集会
- Place of Presentation
  東京大学医科学研究所講堂(東京都・港区)
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-15K21003

1. 武井佳史 (70362233)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. NAKAMURA Masataka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. Takahashi Masahiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. Higuchi Masaya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. Saito Kousuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 船戸紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 藤井雅寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 増子正義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HARA Toshifumi 原 敏文

Hara Toshifumi 原 敏文

Research Projects

Research Products

Co-Researchers

スキルス胃癌の悪性化に伴い発現増加するMETTL27の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of RNA methylation in metastasis of human scirrhous gastric cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of long non-coding RNAs associated with metastasis of human scirrhous gastric cancersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of miRNAs inducing synthetic lethality in ATL cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Elevated METTL9 is associated with peritoneal dissemination in human scirrhous gastric cancers2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elevated Expression of CELSR1 is Associated with Peritoneal Metastasis in Human Scirrhous Gastric Cancers2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Promoter CpG methylation inhibits Kr?ppel-like factor 2 (KLF2)-Mediated repression of hTERT gene expression in human T-cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long Noncoding RNA HOTAIR Promotes Epithelial-Mesenchymal Transition and Is a Suitable Target to Inhibit Peritoneal Dissemination in Human Scirrhous Gastric Cancers2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MicroRNAs Associated with Epithelial-Mesenchymal Transition Can Be Targeted to Inhibit Peritoneal Dissemination of Human Scirrhous Gastric Cancers2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MAGI-1 expression is decreased in several types of human T-cell leukemia cell lines, including adult T-cell leukemia.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Induction of Cell Death by Human T-cell Leukemia Virus Type 1 Tax in a Cell Cycle-Dependent Manner.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB.2016

Author(s)

Journal Title

HARA Toshifumi 原敏文

Hara Toshifumi 原敏文