Koarai Akira 小荒井晃

… Alternative Names

KOARAI AKIRA 小荒井晃

KOARAI Akira 小荒井晃

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Researcher Number	80458059
Other IDs
Affiliation (based on the past Project Information) *help	2020 – 2022: 東北大学, 大学病院, 講師 2018: 東北大学, 大学病院, 講師 2016 – 2018: 東北大学, 大学病院, 助教 2012 – 2014: 東北大学, 大学病院, 助教 2009 – 2011: Wakayama Medical University, 医学部, 助教
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator 酸化ストレス / 慢性閉塞性肺疾患 / 気道上皮 / ウイルス感染 / toll様受容体 / 急性増悪 / DNA / 自然免疫応答 / アラーミン / 閉塞性肺疾患 … More / 自然リンパ球 / IL-33 / Toll様受容体 / タバコ煙 / 増悪 / マクロファージ / 自然免疫 / NF-kB / サイトカイン / 好中球 / Toll-like受容体 / ウイルス Less

To elucidate the involvement of intracellular DNA recognition mechanism in the pathogenesis of COPDPrincipal Investigator
- Principal Investigator
  
  Koarai Akira
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Tohoku University
To elucidate the involvement of innate lymphoid cells in the pathogenesis of COPD and the regulatory mechanismPrincipal Investigator
- Principal Investigator
  
  KOARAI AKIRA
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Role of innate immunity in the pathophysiology of chronic obstructive pulmonary diseasePrincipal Investigator
- Principal Investigator
  
  KOARAI AKIRA
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Mechanisms and management of COPD exacerbations : role of toll-like receptors on the activation of neutrophilPrincipal Investigator
- Principal Investigator
  
  KOARAI Akira
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Wakayama Medical University

All 2022 2021 2018 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

[Book] COPDと自然免疫；Annual Review　2014　呼吸器 (永井厚志、巽浩一郎、桑野和善、高橋和久編)2014
- Author(s)
  小荒井晃、永井厚志、巽浩一郎、桑野和善、高橋和久
- Total Pages
  273
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-24591135
[Book] 肺胞蛋白症(今日の治療指針2010)2010
- Author(s)
  小荒井晃
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21790782
[Book] 薬物療法:慢性閉塞性肺疾患(COPD)のマネジメント改訂版、(橋本修編)2010
- Author(s)
  小荒井晃、一ノ瀬正和
- Total Pages
  158
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-21790782
[Book] 肺胞蛋白症:今日の治療指針2010、総編集山口徹他2010
- Author(s)
  小荒井晃
- Total Pages
  1903
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21790782
[Book] 薬物療法(慢性閉塞性肺疾患(COPD)のマネジメント改訂版)2010
- Author(s)
  小荒井晃、一ノ瀬正和
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] Possible involvement of acetylcholine-mediated inflammation in airway diseases2018
- Author(s)
  Koarai Akira、Ichinose Masakazu
- Journal Title
  
  Allergol. Int.
  
  Volume: 67 Issue: 4 Pages: 460-466
- DOI
  10.1016/j.alit.2018.02.008
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09569
[Journal Article] Oxidative stress enhances the expression of IL-33 in human airway epithelial cells.2018
- Author(s)
  Aizawa H, Koarai A, Shishikura Y, Yanagisawa S, Yamaya M, Sugiura H, Numakura T, Yamada M, Ichikawa T, Fujino N, Noda M, Okada Y, Ichinose M
- Journal Title
  
  Respir Res.
  
  Volume: 27 Issue: 1 Pages: 52-52
- DOI
  10.1186/s12931-018-0752-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05307, KAKENHI-PROJECT-16K09569
[Journal Article] Cigarette smoke augments MUC5AC production via the TLR3-EGFR pathway in airway epithelial cells.2015
- Author(s)
  K. Kanai, A. Koarai, Y.Shishikura, H. Sugiura, T. Ichikawa, T. Kikuchi, K. Akamatsu, T. Hirano, M. Nakanishi, K. Matsunaga, Y. Minakata and M.Ichinose.
- Journal Title
  
  Respir Investig.
  
  Volume: in press Issue: 4 Pages: 137-148
- DOI
  10.1016/j.resinv.2015.01.007
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591135, KAKENHI-PROJECT-24591174, KAKENHI-PROJECT-15K09187, KAKENHI-PROJECT-26461489, KAKENHI-PROJECT-25461502, KAKENHI-PROJECT-26293195
[Journal Article] TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts.2014
- Author(s)
  Ichikawa T, Sugiura H, Koarai A, Minakata Y, Kikuchi T, Morishita Y, Oka A, Kanai K, Kawabata H, Hiramatsu M, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Yamamoto N, Ichinose M.
- Journal Title
  
  J Immunol
  
  Volume: 192 Issue: 11 Pages: 4977-4988
- DOI
  10.4049/jimmunol.1302919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591135, KAKENHI-PROJECT-24591136, KAKENHI-PROJECT-24591174, KAKENHI-PROJECT-25461502, KAKENHI-PROJECT-26293195, KAKENHI-PROJECT-26461489
[Journal Article] ＣＯＰＤと自然免疫2013
- Author(s)
  小荒井　晃
- Journal Title
  
  医学のあゆみ
  
  Volume: 245 Pages: 169-173
- Data Source
  KAKENHI-PROJECT-24591135
[Journal Article] COPD-病態と治療の最新情報； COPDと自然免疫2013
- Author(s)
  小荒井晃
- Journal Title
  
  医学のあゆみ
  
  Volume: 245 Pages: 169-173
- Data Source
  KAKENHI-PROJECT-24591135
[Journal Article] Expression of muscarinic receptors by human macrophages2012
- Author(s)
  Koarai A, et al.
- Journal Title
  
  Eur Respir J
  
  Volume: 39 Issue: 3 Pages: 698-704
- DOI
  10.1183/09031936.00136710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] Cigarette smoke augments the expression and responses of toll-like receptor 3 in human macrophages.2012
- Author(s)
  Koarai A
- Journal Title
  
  Respirology
  
  Volume: 17 Issue: 6 Pages: 1018-1025
- DOI
  10.1111/j.1440-1843.2012.02198.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591097, KAKENHI-PROJECT-23591126, KAKENHI-PROJECT-24591135, KAKENHI-PROJECT-24591136
[Journal Article] Validation of a compact motion sensor for the measurement of physical activity in patients with chronic obstructive pulmonary disease2012
- Author(s)
  Sugino A, Koarai A, et al.
- Journal Title
  
  Respiration
  
  Volume: 83 Issue: 4 Pages: 300-307
- DOI
  10.1159/000330046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] 25-hydroxycholesterol enhances cytokine release and toll-like receptor 3 response in airway epithelial cells2012
- Author(s)
  Koarai A, Yanagisawa S, Sugiura H, Ichikawa T, Kikuchi T, Furukawa K, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
- Journal Title
  
  Respir Res
  
  Volume: 13 Issue: 1 Pages: 63-63
- DOI
  10.1186/1465-9921-13-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591126, KAKENHI-PROJECT-24591135, KAKENHI-PROJECT-24591136
[Journal Article] Increase of nitrosative stress in patients with eosinophilic pneumonia2011
- Author(s)
  Furukawa K, Koarai A, et al.
- Journal Title
  
  Respir Res
  
  Volume: 12 Issue: 1 Pages: 81-91
- DOI
  10.1186/1465-9921-12-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782, KAKENHI-PROJECT-22591097, KAKENHI-PROJECT-23591126
[Journal Article] COPDと自然免疫2011
- Author(s)
  小荒井晃
- Journal Title
  
  総合臨床
  
  Volume: 60 Pages: 508-514
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] Exhaled Nitric Oxide Cutoff Values for Asthma Diagnosis According to Rhinitis and Smoking Status in Japanese Subjects2011
- Author(s)
  Matsunaga K, Koarai A, et al.
- Journal Title
  
  Allergol. Int.
  
  Volume: 60 Issue: 3 Pages: 331-337
- DOI
  10.2332/allergolint.10-OA-0277
- NAID
  130004723045
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782, KAKENHI-PROJECT-22591097
[Journal Article] Improvement of Airflow Limitation by Fluticasone Propionate/Salmeterol in Chronic Obstructive Pulmonary Disease : What is the Specific Marker?2011
- Author(s)
  Akamatsu K, Koarai A, et al.
- Journal Title
  
  Front Pharmacol
  
  Volume: 2 Pages: 36-41
- DOI
  10.3389/fphar.2011.00036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782, KAKENHI-PROJECT-22591097, KAKENHI-PROJECT-23591126
[Journal Article] 拡散2011
- Author(s)
  小荒井晃
- Journal Title
  
  呼吸
  
  Volume: 30 Pages: 358-364
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] COPDの新しい臨床研究-UPLIFT-TORCH以後2011
- Author(s)
  小荒井晃
- Journal Title
  
  呼吸と循環
  
  Volume: 59 Pages: 1009-1015
- NAID
  40019001697
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] Oxidative stress enhances toll-like receptor 3 response to double-stranded RNA in airway epithelial cells.2010
- Author(s)
  Koarai A, et al.
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 42 Pages: 651-660
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] High COPD prevalence in patients with liver disease2010
- Author(s)
  Minakata Y, Koarai A, et al.
- Journal Title
  
  Intern Med
  
  Volume: 49 Pages: 2687-91
- NAID
  130000413428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] High COPD prevalence in patients with liver disease.2010
- Author(s)
  Minakata Y, Koarai A, et al.
- Journal Title
  
  Intern Med
  
  Volume: 49 Pages: 2687-91
- NAID
  130000413428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] Oxidative stress enhances toll-like receptor 3 response to double-stranded RNA in airway epithelial cells2010
- Author(s)
  Koarai A, et al.
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 42 Issue: 6 Pages: 651-660
- DOI
  10.1165/rcmb.2008-0345oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] Oxidative stress enhances toll-like receptor 3 response to double-stranded RNA in airway epithelial cells.2010
- Author(s)
  Koarai A, et al.
- Journal Title
  
  Am J Respir Cell Mol Biol (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] Oxidative stress augments toll-like receptor 8 mediated neutrophilic responses in healthy subjects.2009
- Author(s)
  Yanagisawa S, Koarai A, et al.
- Journal Title
  
  Respir Res 10
  
  Pages: 50-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] Molecular mechanism of the additive effects of leukotriene modifier in a sthmatic patients receiving steroid therapy.2009
- Author(s)
  Matsunaga K, Koarai A, et al.
- Journal Title
  
  Allergol Int. 58
  
  Pages: 89-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] Clinical Application of Exhaled Breath Condensate Analysis in Asthma : Prediction of FEV(1) Improvement by Steroid Therapy2009
- Author(s)
  Matsunaga K, Koarai A, et al.
- Journal Title
  
  Respiration
  
  Volume: 78 Issue: 4 Pages: 393-398
- DOI
  10.1159/000243551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] Activation of toll-like receptor 3 augments myofibroblasts differentiation.2009
- Author(s)
  Sugiura H, Koarai A, et al.
- Journal Title
  
  Am J Respir Cell Mol Biol 40
  
  Pages: 654-662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] Activation of toll-like receptor 3 augments myofibroblasts differentiation2009
- Author(s)
  Sugiura H, Koarai A, et al.
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 40 Issue: 6 Pages: 654-662
- DOI
  10.1165/rcmb.2008-0371oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] Molecular Mechanism of the Additive Effects of Leukotriene Modifier in Asthmatic Patients Receiving Steroid Therapy2009
- Author(s)
  Matsunaga K, Koarai A, et al.
- Journal Title
  
  Allergol. Int.
  
  Volume: 58 Issue: 1 Pages: 89-96
- DOI
  10.2332/allergolint.08-OA-0014
- NAID
  130004477024
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] Oxidative stress augments toll-like receptor 8 mediated neutrophilic responses in healthy subjects2009
- Author(s)
  Yanagisawa S, Koarai A, et al.
- Journal Title
  
  Respir Res
  
  Volume: 10 Issue: 1 Pages: 50-62
- DOI
  10.1186/1465-9921-10-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] 喘息とCOPDの増悪をめぐって増悪から回復期の喘息治療2009
- Author(s)
  小荒井晃、杉浦久敏
- Journal Title
  
  呼吸と循環
  
  Volume: 57 Pages: 169-174
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] The possible role of hematopoietic cell kinase in the pathophysiology of chronic obstructive pulmonary disease2009
- Author(s)
  Yanagisawa S, Koarai A, et al.
- Journal Title
  
  Chest
  
  Volume: 135 Issue: 1 Pages: 94-101
- DOI
  10.1378/chest.07-3020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] The possible role of hematopoietic cell kinase in the pathophysiology of chronic obstructive pulmonary disease.2009
- Author(s)
  Yanagisawa S, Koarai A, et al.
- Journal Title
  
  Chest 135
  
  Pages: 94-101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] 喘息とCOPDの増悪をめぐって増悪から回復期の喘息治療2009
- Author(s)
  小荒井晃、杉浦久敏
- Journal Title
  
  呼吸と循環 57
  
  Pages: 169-174
- Data Source
  KAKENHI-PROJECT-21790782
[Journal Article] Clinical Application of Exhaled Breath Condensate Analysis in Asthma : Prediction of FEV(1) Improvement by Steroid Therapy.2009
- Author(s)
  Matsunaga K, Koarai A, et al.
- Journal Title
  
  Respiration 78
  
  Pages: 393-398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] dsDNA刺激誘導性インターフェロン産生に与えるタバコ煙の影響の検討．2022
- Author(s)
  相澤洋之，小荒井　晃, 沼倉忠久, 市川朋宏, 藤野直也, 山田充啓, 杉浦久敏
- Organizer
  第62回　日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K08510
[Presentation] Effect of oxidative stress on the production of dsDNA-induced interferon in airway epithelial cells2021
- Author(s)
  Akira Koarai, Hiroyuki Aizawa, Tadahisa Numakura, Tomohiro Ichikawa, Naoya Fujino, Mitsuhiro Yamada, Hisatoshi Sugiura
- Organizer
  The 25th Congress of the APSR in Kyoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08510
[Presentation] 酸化ストレスのdsDNA刺激誘導性インターフェロン産生に与える影響検討2021
- Author(s)
  小荒井晃, 宍倉裕，相澤洋之，沼倉忠久, 市川朋宏, 藤野直也, 山田充啓, 杉浦久敏
- Organizer
  第61回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K08510
[Presentation] COPD診療における新規バイオマーカーの可能性2018
- Author(s)
  小荒井晃
- Organizer
  第58回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-16K09569
[Presentation] Oxidative Stress Enhances the Expression of IL-33 in Airway Epithelial Cells During Virus Infection2018
- Author(s)
  Aizawa H, Koarai A, Shishikura Y, Yanagisawa S, Yamaya M, Sugiura H, Numakura T, Yamada M, Ichikawa T, Fujino N, Noda M, Okada Y, Ichinose M
- Organizer
  ATS International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09569
[Presentation] ヒト気道上皮のIL-33発現に対する酸化ストレスの影響2018
- Author(s)
  相澤洋之, 小荒井晃，宍倉裕，柳澤悟，山谷睦雄,　杉浦久敏, 沼倉忠久, 山田充啓，市川朋宏, 藤野直也, 一ノ瀬正和
- Organizer
  第58回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-16K09569
[Presentation] ヒト気道上皮のIL-33発現に対する酸化ストレスの影響2018
- Author(s)
  相澤洋之，小荒井晃，宍倉裕，山谷睦雄，杉浦久敏，沼倉忠久,　山田充啓，一ノ瀬正和
- Organizer
  第67回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-16K09569
[Presentation] Elucidating the pathophysiology of obstructive pulmonary disease -Involvement of innate immunity and quest for the regulatory mechanisms2018
- Author(s)
  Koarai Akira
- Organizer
  The 126th Annual Meeting of Korean Academy of Tuberculosis and Respiratory Diseases (KATRD) meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09569
[Presentation] COPD増悪病態における自然免疫の役割2015
- Author(s)
  小荒井晃
- Organizer
  第100回日本呼吸器学会東北地方会
- Place of Presentation
  フォレスト仙台（宮城県仙台市青葉区）
- Year and Date
  2015-03-07
- Invited
- Data Source
  KAKENHI-PROJECT-24591135
[Presentation] Cigarette smoking augments toll-like receptor 3 expression and responses in macrophages2011
- Author(s)
  A Koarai, et al
- Organizer
  ERS Annual Congress
- Place of Presentation
  Amsterdam, Netherlands
- Year and Date
  2011-09-25
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] 25-hydroxycholesterol enhances cytokines release and toll-like receptor 3 responses in human airway epithelial cells2011
- Author(s)
  A Koarai, et al
- Organizer
  ATS International Conference
- Place of Presentation
  Denver, USA
- Year and Date
  2011-05-17
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] Oxidative stress enhances toll-like receptor 3 response to double-stranded RNA in airway epithelial cells2011
- Author(s)
  A Koarai, et al
- Organizer
  AAAS and AP Airway Disease Summit
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] 25-Hydroxycholesterolの気道上皮におけるサイトカイン産生およびTLR3受容体応答に与える影響の検討2011
- Author(s)
  小荒井晃
- Organizer
  第61回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] 非結核性抗酸菌症に合併したANCA関連血管炎の一例2011
- Author(s)
  神田佳典、小荒井晃
- Organizer
  第78回日本呼吸器学会近畿地方会
- Place of Presentation
  大阪
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] 酸化ストレスのヒト気道上皮におけるdsRNAウイルス刺激応答に対する影響の検討2010
- Author(s)
  小荒井晃
- Organizer
  第50回日本呼吸器学会学術講演会
- Place of Presentation
  京都
- Year and Date
  2010-04-25
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] COPD急性増悪機序の解明および薬物療法の可能性2010
- Author(s)
  小荒井晃
- Organizer
  第19回Pneumo forum
- Place of Presentation
  東京
- Year and Date
  2010-11-13
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] Expression of toll-like receptor 3 in alveolar macrophages from patients with COPD2010
- Author(s)
  Koarai A, et al
- Organizer
  ERS Annual Congress
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] COPD急性増悪機序の解明および薬物療法の可能2010
- Author(s)
  小荒井晃
- Organizer
  第19回Pneumo forum
- Place of Presentation
  東京
- Year and Date
  2010-11-13
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] Expression of toll-like receptor 3 in alveolar macrophages from patients with COPD2010
- Author(s)
  Koarai A, et al.
- Organizer
  ERS Annual Congress 2010
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] Oxidative stress enhances TLR3 response to double-stranded RNA in airway epithelial cells2010
- Author(s)
  Koarai A, et al
- Organizer
  COPD symposium in ASIA2010
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2010-07-31
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] 酸化ストレスのdsRNAウイルス刺激応答に与える影響の検討2010
- Author(s)
  小荒井晃
- Organizer
  第81回閉塞性肺疾患研究会
- Place of Presentation
  東京
- Year and Date
  2010-07-24
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] 酸化ストレスのヒト気道上皮におけるdsRNAウイルス刺激応答に対する影響の検討2010
- Author(s)
  小荒井晃
- Organizer
  第50回日本呼吸器学会学術講演会
- Place of Presentation
  京都(一般演題)
- Year and Date
  2010-04-25
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] Oxidative stress enhances TLR3 response to double-stranded RNA in airway epithelial cells2010
- Author(s)
  Koarai A, et al
- Organizer
  The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] Oxidative stress enhances TLR3 response to double-stranded RNA in airway epithelial cells2009
- Author(s)
  Koarai A, et al
- Organizer
  ATS International Conference
- Place of Presentation
  San Diego, California
- Year and Date
  2009-05-18
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] Oxidative stress enhances TLR3 response to double-stranded RNA in airway epithelial cells2009
- Author(s)
  Koarai A, et al.
- Organizer
  2009 ATS International Conference
- Place of Presentation
  San Diego, California
- Year and Date
  2009-05-18
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] 化学療法が奏効した肺大細胞癌(LCNEC)の1例2009
- Author(s)
  中谷佳裕、小荒井晃
- Organizer
  第37回和歌山悪性腫瘍研究会
- Place of Presentation
  和歌山
- Year and Date
  2009-12-05
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] 酸化ストレスの気道上皮におけるdsRNAウイルス刺激応答に対する影響の検討2009
- Author(s)
  小荒井晃
- Organizer
  第49回日本呼吸器学会総会(一般演題)
- Place of Presentation
  東京
- Year and Date
  2009-06-13
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] 酸化ストレスの気道上皮におけるdsRNAウイルス刺激応答に対する影響の検討2009
- Author(s)
  小荒井晃
- Organizer
  第49回日本呼吸器学会総会
- Place of Presentation
  東京
- Year and Date
  2009-06-13
- Data Source
  KAKENHI-PROJECT-21790782
[Presentation] タバコ煙は気道上皮においてTLR3-EGFR経路を介したムチン産生を増強する
- Author(s)
  金井一修，小荒井晃，杉浦久敏，市川朋宏，菊池崇史，南方良章，一ノ瀬正和
- Organizer
  第54回　日本呼吸器学会学術講演会
- Place of Presentation
  大阪国際会議場(大阪府大阪市北区）
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-24591135
[Presentation] 25-hydroxycholesterolの気道上皮におけるTLR3受容体反応増強作用およびその機序に関する検討
- Author(s)
  小荒井晃, 柳澤悟, 杉浦久敏, 市川朋宏, 菊池崇史, 南方良章, 一ノ瀬正和
- Organizer
  第53回　日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591135
[Presentation] Cigarette smoke augments MUC5AC mucin production via TLR3-EGFR pathway in airway epithelial cells.
- Author(s)
  Kuninobu Kanai, Akira Koarai, Hisatoshi Sugiura, Tomohiro Ichikawa, Takashi Kikuchi, Keiichiro Akamatsu, Tsunahiko Hirano, Masanori Nakanishi, Kazuto Matsunaga, Yoshiaki Minakata and Masakazu Ichinose.
- Organizer
  ERS annual congress 2013
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-24591135
[Presentation] Toll様受容体刺激による気道上皮におけるムチン産生およびその機序に関する検討.
- Author(s)
  金井一修，小荒井晃，杉浦久敏，市川朋宏，菊池崇史，南方良章，一ノ瀬正和
- Organizer
  第53回　日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591135
[Presentation] COPDの増悪～自然免疫をめぐって
- Author(s)
  小荒井晃
- Organizer
  COPD Expert Seminar
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24591135
[Presentation] 閉塞性肺疾患の増悪病態における自然免疫の役割の解明
- Author(s)
  小荒井晃、柳澤悟、金井一修、杉浦久敏、市川朋宏、菊池崇史、赤松啓一郎、平野綱彦、中西正典、松永和人、南方良章、一ノ瀬正和
- Organizer
  第22回　Pneumo Forum
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591135
[Presentation] Cigarette Smoke Augments MUC5AC Mucin Production Via TLR3-EGFR Pathway In Airway Epithelial Cells.
- Author(s)
  K. Kanai, A. Koarai, H. Sugiura, T. Ichikawa, T. Kikuchi, K. Akamatsu, T. Hirano, M. Nakanishi, K. Matsunaga, Y. Minakata and M. Ichinose.
- Organizer
  ATS International Conference 2014
- Place of Presentation
  San Diego Convention Center (San Diego, USA)
- Year and Date
  2014-05-17 – 2014-05-21
- Data Source
  KAKENHI-PROJECT-24591135

1. AIZAWA Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. HIRANO Taizou

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. SHISHIKURA Yutaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. YANAGISAWA Satoru

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. Sugiura Hisatosi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. Yamada Mitsuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 一ノ瀬正和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koarai Akira 小荒井 晃

KOARAI AKIRA 小荒井 晃

KOARAI Akira 小荒井 晃

Research Projects

Research Products

Co-Researchers

To elucidate the involvement of intracellular DNA recognition mechanism in the pathogenesis of COPDPrincipal Investigator

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To elucidate the involvement of innate lymphoid cells in the pathogenesis of COPD and the regulatory mechanismPrincipal Investigator

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Role of innate immunity in the pathophysiology of chronic obstructive pulmonary diseasePrincipal Investigator

Principal Investigator

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Mechanisms and management of COPD exacerbations : role of toll-like receptors on the activation of neutrophilPrincipal Investigator

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[Book] COPDと自然免疫；Annual Review 2014 呼吸器 (永井厚志、巽浩一郎、桑野和善、高橋和久編)2014

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[Book] 肺胞蛋白症(今日の治療指針2010)2010

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[Book] 薬物療法:慢性閉塞性肺疾患(COPD)のマネジメント改訂版、(橋本修編)2010

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[Book] 肺胞蛋白症:今日の治療指針2010、総編集山口徹他2010

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[Book] 薬物療法(慢性閉塞性肺疾患(COPD)のマネジメント改訂版)2010

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[Journal Article] Possible involvement of acetylcholine-mediated inflammation in airway diseases2018

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[Journal Article] Oxidative stress enhances the expression of IL-33 in human airway epithelial cells.2018

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[Journal Article] Cigarette smoke augments MUC5AC production via the TLR3-EGFR pathway in airway epithelial cells.2015

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[Journal Article] TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts.2014

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[Journal Article] ＣＯＰＤと自然免疫2013

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[Journal Article] COPD-病態と治療の最新情報； COPDと自然免疫2013

Koarai Akira 小荒井晃

KOARAI AKIRA 小荒井晃

KOARAI Akira 小荒井晃

[Book] COPDと自然免疫；Annual Review　2014　呼吸器 (永井厚志、巽浩一郎、桑野和善、高橋和久編)2014