HIGASHIYAMA Reiichi 東山礼一

Researcher Number	80459495
Affiliation (based on the past Project Information) *help	2011: 東海大学, 医学部, 奨励研究員 2007 – 2009: 東海大学, 医学部, 奨励研究員
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator マトリックス分解酵素 / コラーゲン / 骨髄細胞 / 肝線維症 Except Principal Investigator 肝線維化 / 間葉系幹細胞 / 造血幹細胞 / 骨髄 / 骨髄幹細胞 / 分化誘導 … More / 星細胞 / マトリックスメタロプロテアーゼ / コラゲナーゼ / 骨髄細胞 / マトリックス分解酵素 / Matrix metalloproteinase / コラーゲン / 肝線維症 Less

Pathophysiological Roles of Mesenchymal Stem Cells and Hematopoietic Stem Cells in Hepatic Fibrosis
- Principal Investigator
  
  INAGAKI Yutaka
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Tokai University
Induction of mobilization and differentiation of bone marrow stem cells for the treatment of fibrosis and liver regenerationPrincipal Investigator
- Principal Investigator
  
  HIGASHIYAMA Reiichi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokai University
Comprehensive Analysis of Production and Degradation of Collagen by Bone Marrow-Derived Cells During Hepatic Fibrogenesis
- Principal Investigator
  
  INAGAKI Yutaka
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokai University

All 2012 2011 2010 2009 2008 2007

All Journal Article Presentation Book Patent

[Book] 肝線維化病態に対する分子形態学的アプローチ.病気の分子形態学.(日本臨床分子形態学会編)2011
- Author(s)
  稲垣豊、東山礼一、茂呂忠、中尾祥絵、皆川香織、三上健一郎
- Publisher
  学際企画
- Data Source
  KAKENHI-PROJECT-22659152
[Journal Article] Novel anti-fibrotic modalities for liver fibrosis : Molecular targeting and regenerative medicine in fibrosis therapy2012
- Author(s)
  Inagaki Y, Higashiyama R, Higashi K
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 27 Pages: 85-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659152
[Journal Article] Interplay between bone marrow and liver in the pathogenesis of hepatic fibrosis2012
- Author(s)
  Inagaki Y, Higashiyama R
- Journal Title
  
  Hepatol Res
  
  Volume: 42 Pages: 543-548
- NAID
  10031144268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659152
[Journal Article] Differential contribution of dermal resident and bone marrow-derived cells to collagen production during wound healing and fibrogenesis in mice.2011
- Author(s)
  Reiichi Higashiyama
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 131 Pages: 529-536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659152
[Journal Article] Differential contribution of dermal resident and bone marrow-derived cells to collagen production during wound healing and fibrogenesis in mice2011
- Author(s)
  Higashiyama R, Nakao S, Inagaki Y, 他9名
- Journal Title
  
  J Invest Dermatol
  
  Volume: 131 Pages: 529-536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659152
[Journal Article] Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice.2009
- Author(s)
  Reiichi Higashiyama, Tadashi Moro, Sachie Nakao, Kenichiro Mikami, Hiroshi Fukumitsu, Yoshitaka Ueda, Kazuo Ikeda, Eijiro Adachi, George Bou-Gharios, Isao Okazaki, Yutaka Inagaki
- Journal Title
  
  Gastroenterology 137
  
  Pages: 1459-1466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790511
[Journal Article] Negligible Contribution of Bone Marrow-Derived Cells to Collagen Production during Hepatic Fibrogenesis in Mice2009
- Author(s)
  Reiichi Higashiyama
- Journal Title
  
  Gastroenterology 137
  
  Pages: 1459-1466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790511
[Journal Article] Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-72008
- Author(s)
  Inagaki Y, Higashi K, Higashiyama R, 他10名
- Journal Title
  
  Gastroenterology 134
  
  Pages: 1180-1190
- NAID
  40016346603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590792
[Journal Article] Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis2008
- Author(s)
  Moro T, Higashiyama R, Inagaki Y, 他7名
- Journal Title
  
  Life Sciences 83
  
  Pages: 531-539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590792
[Journal Article] 肝線維化機序の解明で今何が問題になっているのか2008
- Author(s)
  稲垣豊、東山礼一
- Journal Title
  
  肝胆膵 57
  
  Pages: 187-192
- Data Source
  KAKENHI-PROJECT-19590792
[Journal Article] Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis.2008
- Author(s)
  Tadashi Moro, Yoshihito Shimoyama, Miwa Kushida, Yun Yu Hong, Sachie Nakao, Reiichi Higashiyama, Yoshihiko Sugioka, Hideo Inoue, Isao Okazaki, Yutaka Inagaki
- Journal Title
  
  Life Sciences 83
  
  Pages: 531-539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790511
[Journal Article] Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7.2008
- Author(s)
  Yutaka Inagaki, Kiyoshi Higashi, Miwa Kushida, Yun Yu Hong, Sachie Nakao, Reiichi Higashiyama, Tadashi Moro, Johbu Itoh, Toshiyuki Mikami, Toru Kimura, Goshi Shiota, Ichiro Kuwabara, Isao Okazaki
- Journal Title
  
  Gastroenterology 134
  
  Pages: 1180-1190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790511
[Journal Article] Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice2007
- Author(s)
  Higashiyama R, Inagaki Y, Hong YY, 他8名
- Journal Title
  
  Hepatology 45
  
  Pages: 213-222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590792
[Journal Article] Bone marrow cells in the liver : diverse cells, diverse effects2007
- Author(s)
  Inagaki Y, Higashiyama R, Watanabe T, 他1名
- Journal Title
  
  Hepatology 46
  
  Pages: 604-606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590792
[Journal Article] Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of live fibrosis in mice2007
- Author(s)
  Reiichi Higashiyama
- Journal Title
  
  Hepatology 45
  
  Pages: 213-222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590792
[Journal Article] Treatment Strategy for liver fibrosis through recruitment and differentiation of bone marrow stem/progenitor cells2007
- Author(s)
  Inagaki Y, Higashiyama R, Okazaki I
- Journal Title
  
  Hepatol Res 37
  
  Pages: 991-993
- NAID
  10019796168
- Data Source
  KAKENHI-PROJECT-19590792
[Patent] 生体組織再生を促進させる薬剤を製造するための加工細胞2010
- Inventor(s)
  稲垣豊、東山礼一東清史、斎藤幸一
- Industrial Property Rights Holder
  学校法人東海大学、住友化学工業株式会社
- Industrial Property Number
  2010-122501
- Filing Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-22659152
[Presentation] 骨髄細胞由来Matrix metalloproteinases (MMPs)による肝線維化改善機序の解明2010
- Author(s)
  東山礼一
- Organizer
  第9回再生医療学会総会
- Place of Presentation
  広島
- Year and Date
  2010-03-18
- Data Source
  KAKENHI-PROJECT-20790511
[Presentation] 肝線維化と再生の病態連繋における骨髄と末梢の臓器相関.シンポジウム2「肝幹細胞と肝再生」2010
- Author(s)
  稲垣豊、東山礼一、三上健一郎
- Organizer
  第17回肝細胞研究会
- Place of Presentation
  秋田アトリオン(秋田)
- Year and Date
  2010-06-19
- Data Source
  KAKENHI-PROJECT-22659152
[Presentation] Matrix metalloproteinase (MMP)-13による線維化改善と類洞構造の修復を介した肝再生治療戦略2010
- Author(s)
  東山礼一
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-22659152
[Presentation] Matrix metalloproteinase (MMP)-13 enhances migration of bone marrow-derived cells and contributes to the repair of experimental liver fibrosis.2010
- Author(s)
  Reiichi Higashiyama
- Organizer
  15th International Symposium on Cells of the Hepatic Sinusoid
- Place of Presentation
  Pasadena, CA
- Year and Date
  2010-08-31
- Data Source
  KAKENHI-PROJECT-22659152
[Presentation] Matrix metalloproteinase(MMP)-13による線維化改善と類洞構造の修復を介した肝再生治療戦略.移植・再生医療ワークショップ2「肝再生医学-臨床応用を目指した研究の新展開」2010
- Author(s)
  東山礼一、三上健一郎、稲垣豊
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  ホテルメトロポリタン山形(山形)
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-22659152
[Presentation] 皮膚創傷治癒ならびに線維化過程における骨髄由来細胞のコラーゲン合成への関与2009
- Author(s)
  東山礼一
- Organizer
  第108回日本皮膚科学会総会
- Place of Presentation
  福岡
- Year and Date
  2009-04-25
- Data Source
  KAKENHI-PROJECT-20790511
[Presentation] Role of Bone Marrow in Pathophysiology of Hepatic Fibrosis and Regeneration2009
- Author(s)
  Reiichi Higashiyama
- Organizer
  Symposium VI "Molecular and Cellular Mechanisms of Tissue Remodeling and Fibrosis-Their Therapeutic Implications" Yokosuka Science Festa 2009
- Place of Presentation
  Yokosuka
- Year and Date
  2009-06-06
- Data Source
  KAKENHI-PROJECT-20790511
[Presentation] Matrix metallo-proteinases enhance migration of bone marrow-derived cells and contribute to the regression of experimental liver fibrosis2008
- Author(s)
  Higashiyama R, et.al
- Organizer
  59th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco, CA
- Year and Date
  2008-11-03
- Data Source
  KAKENHI-PROJECT-19590792
[Presentation] 骨髄由来細胞の動員とMatrix metalloproteinases (MMPs)発現による肝線維化改善機序の解明2008
- Author(s)
  東山礼一
- Organizer
  第44回日本肝臓学会総会ワークショップ(8)「肝障害と修復に関する研究の展開」
- Place of Presentation
  松山
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-20790511
[Presentation] Matrix metalloproteinases enhance migration of bone marrow-derived cells and contribute to the regression of experimental liver fibrosis.2008
- Author(s)
  Reiichi Higashiyama
- Organizer
  59th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco, CA
- Year and Date
  2008-11-03
- Data Source
  KAKENHI-PROJECT-19590792
[Presentation] 皮膚創傷治癒ならびに線維化過程における骨髄由来細胞のコラーゲン合成への関与2008
- Author(s)
  東山礼一
- Organizer
  第40回日本結合組織学会学術大会・第55回マトリックス研究会大会合同学術集会
- Place of Presentation
  東京
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-20790511
[Presentation] Matrix metalloproteinases enhance migration of bone marrow-derived cells and contribute to the regression of experimental liver fibrosis.2008
- Author(s)
  Reiichi Higashiyama
- Organizer
  59th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco, CA
- Year and Date
  2008-11-03
- Data Source
  KAKENHI-PROJECT-20790511
[Presentation] 皮膚創傷治癒ならびに線維化過程における骨髄由来細胞のコラーゲン合成への関与2008
- Author(s)
  東山礼一、他
- Organizer
  第40回日本結合組織学会学術大会・第55回マトリックス研究会大会合同学術集会
- Place of Presentation
  東京
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-19590792
[Presentation] Matrix metalloproteinases enhance migration of bone marrow-derived cells and contribute to the regression of experimental liver fibrosis2008
- Author(s)
  Reiichi Higashiyama
- Organizer
  59th Annual Meeting of the American Associa tion for the Study of Liver Diseases
- Place of Presentation
  San Francisco, CA
- Year and Date
  2008-11-03
- Data Source
  KAKENHI-PROJECT-20790511
[Presentation] 皮膚創傷治癒ならびに線維化過程における骨髄由来細胞のコラーゲン合成への関与.2008
- Author(s)
  東山礼一
- Organizer
  第40回日本結合組織学会学術大会・第55回マトリックス研究会大会合同学術集会
- Place of Presentation
  東京
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-19590792
[Presentation] 骨髄由来細胞の動員とMatrix metalloproteinases(MMPs)発現による肝線維化改善機序の解明2008
- Author(s)
  東山礼一
- Organizer
  第44回日本肝臓学会総会、ワークショップ(8)「肝障害と修復に関する研究の展開」
- Place of Presentation
  松山
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-20790511
[Presentation] 骨髄由来細胞の動員とMatrix metalloproteinases (MMPs)発現による肝線維化改善機序の解明2008
- Author(s)
  東山礼一、他
- Organizer
  第44回日本肝臓学会総会、ワークショップ(8)「肝障害と修復に関する研究の展開」
- Place of Presentation
  松山
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-19590792
[Presentation] 骨髄細胞由来Matrix metalloproteinases (MMPs)による肝線維化改善機序の解明2008
- Author(s)
  東山礼一
- Organizer
  第22回肝類洞壁細胞研究会ワークショップ2「肝再生と肝類洞壁細胞」
- Place of Presentation
  久留米
- Year and Date
  2008-11-29
- Data Source
  KAKENHI-PROJECT-20790511
[Presentation] 骨髄細胞由来Matrix metalloproteinases(MMPs)による肝線維化改善機序の解明2008
- Author(s)
  東山礼一
- Organizer
  第22回肝類洞壁細胞研二究会、ワークショップ2「肝再生と肝類洞壁細胞」
- Place of Presentation
  久留米
- Year and Date
  2008-11-29
- Data Source
  KAKENHI-PROJECT-20790511
[Presentation] 骨髄細胞由来Matrix metalloproteinases (MMPs)による肝線維化改善機序の解明.2008
- Author(s)
  東山礼一
- Organizer
  第22回肝類洞壁細胞研究会、ワークショップ2「肝再生と肝類洞壁細胞」
- Place of Presentation
  久留米
- Year and Date
  2008-11-29
- Data Source
  KAKENHI-PROJECT-19590792
[Presentation] 骨髄細胞由来Matrix metalloproteinases (MMPs) による肝線維化改善機序の解明2008
- Author(s)
  東山礼一、他
- Organizer
  第22回肝類洞壁細胞研究会、ワークショップ2「肝再生と肝類洞壁細胞」
- Place of Presentation
  久留米
- Year and Date
  2008-11-29
- Data Source
  KAKENHI-PROJECT-19590792
[Presentation] ブレオマイシン誘導皮膚硬化症における骨髄由来細胞の関与.2007
- Author(s)
  東山礼一
- Organizer
  第39回日本結合組織学会学術大会・第54回マトリックス研究会大会合同学術集会
- Place of Presentation
  東京
- Year and Date
  2007-05-11
- Data Source
  KAKENHI-PROJECT-19590792
[Presentation] ブレオマイシン誘導皮膚硬化症における骨髄由来細胞の関与2007
- Author(s)
  東山礼一、他
- Organizer
  第39回日本結合組織学会学術大会・第54回マトリックス研究会大会合同学術集会
- Place of Presentation
  東京
- Year and Date
  2007-05-11
- Data Source
  KAKENHI-PROJECT-19590792

1. INAGAKI Yutaka (80193548)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
2. MATSUZAKI Yumi (50338183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIGASHIYAMA Reiichi 東山 礼一

Research Projects

Research Products

Co-Researchers

Pathophysiological Roles of Mesenchymal Stem Cells and Hematopoietic Stem Cells in Hepatic Fibrosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Induction of mobilization and differentiation of bone marrow stem cells for the treatment of fibrosis and liver regenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive Analysis of Production and Degradation of Collagen by Bone Marrow-Derived Cells During Hepatic Fibrogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 肝線維化病態に対する分子形態学的アプローチ.病気の分子形態学.(日本臨床分子形態学会編)2011

Author(s)

Publisher

Data Source

[Journal Article] Novel anti-fibrotic modalities for liver fibrosis : Molecular targeting and regenerative medicine in fibrosis therapy2012

Author(s)

Journal Title

Data Source

[Journal Article] Interplay between bone marrow and liver in the pathogenesis of hepatic fibrosis2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Differential contribution of dermal resident and bone marrow-derived cells to collagen production during wound healing and fibrogenesis in mice.2011

Author(s)

Journal Title

Data Source

[Journal Article] Differential contribution of dermal resident and bone marrow-derived cells to collagen production during wound healing and fibrogenesis in mice2011

Author(s)

Journal Title

Data Source

[Journal Article] Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice.2009

Author(s)

Journal Title

Data Source

[Journal Article] Negligible Contribution of Bone Marrow-Derived Cells to Collagen Production during Hepatic Fibrogenesis in Mice2009

Author(s)

Journal Title

Data Source

[Journal Article] Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-72008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis2008

Author(s)

Journal Title

Data Source

[Journal Article] 肝線維化機序の解明で今何が問題になっているのか2008

Author(s)

Journal Title

Data Source

[Journal Article] Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis.2008

Author(s)

Journal Title

Data Source

[Journal Article] Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7.2008

Author(s)

Journal Title

Data Source

[Journal Article] Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice2007

Author(s)

Journal Title

Data Source

[Journal Article] Bone marrow cells in the liver : diverse cells, diverse effects2007

Author(s)

Journal Title

Data Source

HIGASHIYAMA Reiichi 東山礼一