Kunimoto Hiroyoshi 國本博義

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KUNIMOTO Hiroyoshi 國本博義

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Researcher Number	80464923
Other IDs
Affiliation (Current)	2025: 横浜市立大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2024: 横浜市立大学, 医学部, 講師 2019 – 2023: 横浜市立大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 骨髄系腫瘍 / タンパク質恒常性破綻 / エピゲノム制御異常 / 抗がん剤耐性機構 / 高リスク染色体異常 / アポトーシス / p53 / p38 / GADD45g / apoptosis … More / EZH2 / OCI-AML20 / YCU-AML1 / 炎症性サイトカイン / 造血幹細胞 / Tet2 / 慢性骨髄単球性白血病 / クローン性造血 / GM-CSF / TET2 … More Except Principal Investigator ミトコンドリア / 白血病幹細胞 / 代謝 / 恒常性 / タンパク質 / マイトファジー / ミトコンドリアダイナミックス / 白血病 Less

Elucidating molecular basis of myeloid cancers with epigenetic dysregulation and collapse of protein homeostasisPrincipal Investigator
- Principal Investigator
  
  國本博義
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Yokohama City University
タンパク質恒常性制御による白血病幹細胞生成・維持の分子メカニズム解明
- Principal Investigator
  
  中島秀明
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Yokohama City University
Investigating molecular basis of chemoresistance using a novel leukemia cell line harboring high-risk chromosome abnormalitiesPrincipal Investigator
- Principal Investigator
  
  KUNIMOTO Hiroyoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Yokohama City University
Regulation of leukemic stem cells by mitochondrial dynamics
- Principal Investigator
  
  NAKAJIMA Hideaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Yokohama City University
Investigating a novel therapeutic strategy for preleukemic clonal hematopoiesis based on proinflammatory cytokine-mediated cell extrinsic mechanism of clonal expansionPrincipal Investigator
- Principal Investigator
  
  KUNIMOTO Hiroyoshi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Yokohama City University

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Clinical and genetic features of Japanese cases of MDS associated with VEXAS syndrome2023
- Author(s)
  Kunimoto Hiroyoshi、Miura Ayaka、Maeda Ayaka、Tsuchida Naomi、Uchiyama Yuri、Kunishita Yosuke、Nakajima Yuki、Takase-Minegishi Kaoru、Yoshimi Ryusuke、Miyazaki Takuya、Hagihara Maki、Yamazaki Etsuko、Kirino Yohei、Matsumoto Naomichi、Nakajima Hideaki
- Journal Title
  
  International Journal of Hematology
  
  Volume: - Issue: 4 Pages: 494-502
- DOI
  10.1007/s12185-023-03598-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17428, KAKENHI-PROJECT-23K15353, KAKENHI-PROJECT-23K07229, KAKENHI-PROJECT-21K08400
[Journal Article] Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia2023
- Author(s)
  Knorr Katherine、Rahman Jahan、Erickson Caroline、Wang Eric、Monetti Mara、Li Zhuoning、Ortiz-Pacheco Juliana、Jones Andrew、Lu Sydney X.、Stanley Robert F.、Baez Maria、Fox Nina、Castro Cynthia、Marino Alessandra E.、Jiang Caroline、Penson Alex、Hogg Simon J.、Mi Xiaoli、Nakajima Hideaki、Kunimoto Hiroyoshi、et al.
- Journal Title
  
  Nature Cancer
  
  Volume: 4 Issue: 12 Pages: 1675-1692
- DOI
  10.1038/s43018-023-00656-2
- Data Source
  KAKENHI-PROJECT-21K08400
[Journal Article] O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation2023
- Author(s)
  Soma Shunsuke、Murakami Koichi、Fukuchi Yumi、Kunimoto Hiroyoshi、Nakajima Hideaki
- Journal Title
  
  Stem Cells
  
  Volume: 42 Issue: 1 Pages: 55-63
- DOI
  10.1093/stmcls/sxad076
- Data Source
  KAKENHI-PROJECT-21K08400
[Journal Article] Incidence and Risk of Hematological Adverse Events Associated With Immune Checkpoint Inhibitors: A Systematic Literature Review and Meta-Analysis2023
- Author(s)
  Ohashi Takuma、Takase-Minegishi Kaoru、Maeda Ayaka、Hamada Naoki、Yoshimi Ryusuke、Kirino Yohei、Teranaka Hiroshi、Kunimoto Hiroyoshi、Hagihara Maki、Matsumoto Kenji、Namkoong Ho、Horita Nobuyuki、Nakajima Hideaki
- Journal Title
  
  Journal of Hematology
  
  Volume: 12 Issue: 2 Pages: 66-74
- DOI
  10.14740/jh1090
- Data Source
  KAKENHI-PROJECT-21K08400
[Journal Article] Clinical risk factors for patients with myelodysplastic syndromes undergoing allogeneic hematopoietic stem cell transplantation2022
- Author(s)
  Teshigawara-Tanabe Haruka、Hagihara Maki、Aoki Jun、Koyama Satoshi、Takahashi Hiroyuki、Nakajima Yuki、Kunimoto Hiroyoshi、Tachibana Takayoshi、Miyazaki Takuya、Matsumoto Kenji、Tanaka Masatsugu、Yamazaki Etsuko、Fujisawa Shin、Kanamori Heiwa、Taguri Masataka、Nakajima Hideaki
- Journal Title
  
  Hematology
  
  Volume: 27 Issue: 1 Pages: 620-628
- DOI
  10.1080/16078454.2022.2052601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08400
[Journal Article] Aberrant <i>EVI1</i> splicing contributes to <i>EVI1</i>-rearranged leukemia2022
- Author(s)
  Tanaka Atsushi、Kunimoto Hiroyoshi et al.
- Journal Title
  
  Blood
  
  Volume: 140 Issue: 8 Pages: 875-888
- DOI
  10.1182/blood.2021015325
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08400, KAKENHI-PROJECT-21K08432, KAKENHI-PROJECT-21K12239, KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H03714, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-21J15620, KAKENHI-PROJECT-20H03717, KAKENHI-PROJECT-23K24368
[Journal Article] OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy2021
- Author(s)
  Murakami Koichi、 ... 、Takubo Keiyo、Okamoto Shinichiro、Tamura Tomohiko、Nakajima Hideaki
- Journal Title
  
  Cell Reports
  
  Volume: 34 Issue: 1 Pages: 108579-108579
- DOI
  10.1016/j.celrep.2020.108579
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-19K17864
[Journal Article] TET2: A cornerstone in normal and malignant hematopoiesis2020
- Author(s)
  Kunimoto Hiroyoshi、Nakajima Hideaki
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 1 Pages: 31-40
- DOI
  10.1111/cas.14688
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17864
[Journal Article] Establishment of a High-risk MDS/AML Cell Line YCU-AML1 and its Xenograft Model Harboring t(3;3) and Monosomy 72020
- Author(s)
  Kunimoto Hiroyoshi、Fukuchi Yumi、Murakami Koichi、Ikeda Junji、Teranaka Hiroshi、Kato Ikuma、Miyazaki Takuya、Enaka Makiko、Mitsuhashi Takayuki、Yamazaki Etsuko、Kameyama Kaori、Murata Mitsuru、Okamoto Shinichiro、Nakajima Hideaki
- Journal Title
  
  HemaSphere
  
  Volume: 4 Issue: 5
- DOI
  10.1097/hs9.0000000000000469
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17864
[Journal Article] Clonal hematopoiesis: Molecular basis and clinical relevance2020
- Author(s)
  Kunimoto Hiroyoshi、Nakajima Hideaki
- Journal Title
  
  Leukemia Research
  
  Volume: 98 Pages: 106457-106457
- DOI
  10.1016/j.leukres.2020.106457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17864
[Presentation] PRC2を介したアポトーシス回避機構はinv(3)/t(3;3)と-7を有する白血病の治療標的である2023
- Author(s)
  國本博義・三浦彩華・匂坂麻衣子・伊藤美恵子・本間大輔・堤信二・佐久間敬之・大橋卓馬・寺中寛・池田順治・吉見昭秀・後藤裕明・中島秀明
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08400
[Presentation] 急性骨髄性白血病においてPRDM16による代謝リプログラミングはシタラビン耐性を誘導する2023
- Author(s)
  池田順治・國本博義・齋藤祐介・辻本信一・竹内正宣・三浦彩華・村上紘一・加藤生真・菱木貴子・早川典代・松浦友美・多胡めぐみ・横山明彦・柴徳生・田村智彦・伊藤秀一・中島秀明
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08400
[Presentation] PRC2-mediated apoptosis evasion is a therapeutic target of MDS/AML harboring inv(3)/t(3;3) and -72023
- Author(s)
  1.Kunimoto H, Miura A, Sagisaka M, Ito M, Honma D, Tsutsumi S, Sakuma T, Ohashi T, Teranaka H, Ikeda J, Toya T, Harada Y, Doki N, Cai SF, Yoshimi A, Goto H, Levine RL, Nakajima H
- Organizer
  65th American Society of Hematology (ASH) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08400
[Presentation] Clinical and genetic features of MDS associated with VEXAS syndrome2023
- Author(s)
  Hiroyoshi Kunimoto
- Organizer
  The 85th JSH Annual Meeting, JSH-ASH Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08400
[Presentation] 忠実度の高いヒト高リスクMDS/AMLモデルの構築2020
- Author(s)
  國本　博義
- Organizer
  第24回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-19K17864
[Presentation] 忠実度の高いヒト高リスクMDS/AMLモデルの構築2020
- Author(s)
  國本博義・村上紘一・池田順治・寺中寛・加藤生真・宮崎拓也・江中牧子・三ツ橋雄之・山崎悦子・亀山香織・村田満・岡本真一郎・中島秀明
- Organizer
  第24回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-19K17864
[Presentation] 3番染色体転座と7番染色体欠失を有する高リスクMDS/AMLからの細胞株と異種移植モデルの樹立2020
- Author(s)
  國本博義・福地由美・村上紘一・池田順治・寺中寛・加藤生真・宮崎拓也・江中牧子・三ツ橋雄之・山崎悦子・亀山香織・村田満・岡本真一郎・中島秀明
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17864

1. NAKAJIMA Hideaki (30217723)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
2. TAKUBO Keiyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 土田奈緒美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kunimoto Hiroyoshi 國本 博義

KUNIMOTO Hiroyoshi 國本 博義

Research Projects

Research Products

Co-Researchers

Elucidating molecular basis of myeloid cancers with epigenetic dysregulation and collapse of protein homeostasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

タンパク質恒常性制御による白血病幹細胞生成・維持の分子メカニズム解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigating molecular basis of chemoresistance using a novel leukemia cell line harboring high-risk chromosome abnormalitiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of leukemic stem cells by mitochondrial dynamics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigating a novel therapeutic strategy for preleukemic clonal hematopoiesis based on proinflammatory cytokine-mediated cell extrinsic mechanism of clonal expansionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Clinical and genetic features of Japanese cases of MDS associated with VEXAS syndrome2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Incidence and Risk of Hematological Adverse Events Associated With Immune Checkpoint Inhibitors: A Systematic Literature Review and Meta-Analysis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical risk factors for patients with myelodysplastic syndromes undergoing allogeneic hematopoietic stem cell transplantation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aberrant <i>EVI1</i> splicing contributes to <i>EVI1</i>-rearranged leukemia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TET2: A cornerstone in normal and malignant hematopoiesis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of a High-risk MDS/AML Cell Line YCU-AML1 and its Xenograft Model Harboring t(3;3) and Monosomy 72020

Author(s)

Journal Title

DOI

Data Source

Kunimoto Hiroyoshi 國本博義

KUNIMOTO Hiroyoshi 國本博義