Yamanoi Kazuhiro 山ノ井一裕

Researcher Number	80464965
Other IDs	https://orcid.org/0000-0002-5361-8053
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2021 – 2023: 慶應義塾大学, 医学部(信濃町), 講師 2019 – 2020: 慶應義塾大学, 医学部(信濃町), 助教 2017 – 2018: 信州大学, 先鋭領域融合研究群バイオメディカル研究所, 助教(特定雇用)
Review Section/Research Field	Principal Investigator Basic Section 49020:Human pathology-related / Human pathology
Keywords	Principal Investigator MUC6 / αGlcNAc / 糖鎖 / 幽門腺型粘液 / 粘液 / 幽門腺 / carcinoma / mucin / glycosylation / 粘性 … More / TFF2 / 多段階発癌 / alphaGlcNAc / 分化 / 胃底腺型胃癌 / BilIN / 胆道癌 / aGlcNAc / FSCN / filopodia / 腺癌 / 肺癌 / 胃型粘液 / αlcNAc / 胃型形質 / 腫瘍マーカー / 前がん / 多段階発がん / 糖鎖修飾 / 幽門腺型 / 診断病理学 / MDA / 胃型腺癌 / LEGH / HIK1083 / 病理診断 / がん Less

幽門腺型粘液の糖鎖に注目したがん抑制機構の解明と、早期がん診断への応用Principal Investigator
- Principal Investigator
  
  山ノ井一裕
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Keio University
Significance of reduced alphaGlcNAc glycosylation in pyloric gland neoplasmsPrincipal Investigator
- Principal Investigator
  
  Yamanoi Kazuhiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Keio University
Significance of alphaGlcNAc expression status in human tumorsPrincipal Investigator
- Principal Investigator
  
  Yamanoi Kazuhiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Shinshu University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Decreased expression of TFF2 and decreased αGlcNAc glycosylation are malignant biomarkers of pyloric gland adenoma of the duodenum2023
- Author(s)
  Kazuhiro Yamanoi, Chifumi Fujii, Atsushi Nakayama, Noriko Matsuura, Yusaku Takatori, Motohiko Kato, Naohisa Yahagi, Jun Nakayama
- Journal Title
  
  Scientific reports
  
  Volume: 13 Issue: 1 Pages: 21641-21641
- DOI
  10.1038/s41598-023-49040-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06430, KAKENHI-PROJECT-23K08190
[Journal Article] 多段階発癌過程における幽門腺粘液の糖鎖修飾の変化とその臨床病理学的意義2023
- Author(s)
  山ノ井　一裕、藤井　千文、中山　淳
- Journal Title
  
  月刊細胞　The Cell
  
  Volume: 12 Pages: 52-55
- Data Source
  KAKENHI-PROJECT-23K06430
[Journal Article] MUC6 expression is a preferable prognostic marker for invasive mucinous adenocarcinoma of the lung2022
- Author(s)
  Yamanoi K, Fujii C, Yuzuriha H, Kumazawa M, Shimoda M, Emoto K, Asamura H, Nakayama J
- Journal Title
  
  Histochemistry and Cell Biology
  
  Volume: Online ahead of print Issue: 6 Pages: 671-684
- DOI
  10.1007/s00418-022-02093-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03441, KAKENHI-PROJECT-19K16555, KAKENHI-PROJECT-23K24116
[Journal Article] Glycosylation of MUC6 by α1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy2022
- Author(s)
  Yuki A, Fujii C, Yamanoi K, Matoba H, Harumiya S, Kawakubo M, Nakayama J
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 2 Pages: 576-586
- DOI
  10.1111/cas.15209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03441, KAKENHI-PROJECT-20K09053, KAKENHI-PROJECT-19K16555
[Journal Article] Decreased alpha‐1,4‐linked N‐acetylglucosamine glycosylation in biliary tract cancer progression from biliary intraepithelial neoplasia to invasive adenocarcinoma2020
- Author(s)
  Okumura Motohiro、Yamanoi Kazuhiro、Uehara Takeshi、Nakayama Jun
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 12 Pages: 4629-4635
- DOI
  10.1111/cas.14677
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16555, KAKENHI-PROJECT-19H03441
[Journal Article] Diffuse MIST1 expression and decreased α1,4‐linked N‐acetylglucosamine (αGlcNAc) glycosylation on MUC6 are distinct hallmarks for gastric neoplasms showing oxyntic gland differentiation2020
- Author(s)
  Yamada Shigenori、Yamanoi Kazuhiro、Sato Yoshiko、Nakayama Jun
- Journal Title
  
  Histopathology
  
  Volume: 77 Issue: 3 Pages: 413-422
- DOI
  10.1111/his.14165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16555, KAKENHI-PROJECT-19H03441
[Journal Article] αGlcNAc and its catalyst α4GnT are diagnostic and prognostic markers in uterine cervical tumor, gastric type2019
- Author(s)
  Ida Koichi、Yamanoi Kazuhiro、Asaka Shiho、Takeuchi Hodaka、Miyamoto Tsutomu、Shiozawa Tanri、Nakayama Jun
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1
- DOI
  10.1038/s41598-019-49376-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16555
[Journal Article] Analysis of A4gnt Knockout Mice Reveals an Essential Role for Gastric Sulfomucins in Preventing Gastritis Cystica Profunda2019
- Author(s)
  Masatomo Kawakubo, Hitomi Komura, Yukinobu Goso, Motohiro Okumura, Yoshiko Sato, Chifumi Fujii, Masaki Miyashita, Nobuhiko Arisaka, Satoru Harumiya, Kazuhiro Yamanoi, Shigenori Yamada, Shigeru Kakuta, Hiroto Kawashima, Michiko N Fukuda, Minoru Fukuda, Jun Nakayama
- Journal Title
  
  J Histochem Cytochem
  
  Volume: 67 Issue: 10 Pages: 759-770
- DOI
  10.1369/0022155419860134
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08419, KAKENHI-PROJECT-17K17779, KAKENHI-PROJECT-19K16555, KAKENHI-PROJECT-17K19542
[Journal Article] Gastric gland mucin-specific O-glycan expression decreases as tumor cells progress from lobular endocervical gland hyperplasia to cervical mucinous carcinoma, gastric type2018
- Author(s)
  Yamanoi Kazuhiro、Ishii Keiko、Tsukamoto Michihiko、Asaka Shiho、Nakayama Jun
- Journal Title
  
  Virchows Archiv
  
  Volume: 473 Issue: 3 Pages: 305-311
- DOI
  10.1007/s00428-018-2381-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15640
[Journal Article] αGlcNAc glycosylation on gastric gland mucin is a biomarker of malignant potential for gastric cancer, Barrett’s adenocarcinoma, and pancreatic cancer2018
- Author(s)
  Yamanoi K, Nakayama J
- Journal Title
  
  Histochemistry and Cell Biology
  
  Volume: 印刷中 Issue: 6 Pages: 569-575
- DOI
  10.1007/s00418-018-1667-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04712, KAKENHI-PROJECT-17K15640
[Journal Article] Gastric gland mucin-specific O-glycan expression decreases with tumor progression from precursor lesions to pancreatic cancer2017
- Author(s)
  Ayumu Ohya, Kazuhiro Yamanoi, Hisashi Shimojo, Jun Nakayama
- Journal Title
  
  CANCER SCIENCE
  
  Volume: 108 Issue: 9 Pages: 1897-1902
- DOI
  10.1111/cas.13317
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15640, KAKENHI-PROJECT-15H04712
[Presentation] 幽門腺型粘液の糖鎖修飾は、胃、膵・胆道、子宮頸部、肺において早期癌マーカーとなり得るのみならず、癌の悪性化にも関わる2024
- Author(s)
  山ノ井　一裕、藤井　千文、中山　淳
- Organizer
  2024年がん関連三学会 Rising Star ネットワーキング
- Data Source
  KAKENHI-PROJECT-23K06430
[Presentation] 十二指腸幽門腺型腺腫において、TFF2発現低下とαGlcNAc糖鎖修飾低下は悪性度のバイオマーカーとなる2023
- Author(s)
  山ノ井　一裕、藤井　千文、中山　敦史、松浦　倫子、高取　祐作、加藤　元彦、矢作　直久、中山　淳
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K06430
[Presentation] αGlcNAc binding to MUC6 enhances suppression of malignant phenotypes of pancreatic cancer cells2022
- Author(s)
  Chifumi Fujii, Kazuhiro Yamanoi, Hisanori Matoba, Jun Nakayama
- Organizer
  The 81st Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-19K16555
[Presentation] Phenotypic change of pyloric gland mucin represents potentially malignant biomarker for various neoplasms2022
- Author(s)
  Kazuhiro Yamanoi, Chifumi Fujii, Masayuki Shimoda, Jun Nakayama
- Organizer
  The 81st Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-19K16555
[Presentation] MUC6 expression is a novel preferable prognostic marker for　invasive mucinous adenocarcinoma of the lung.2021
- Author(s)
  Kazuhiro Yamanoi, Chifumi Fujii, Jun Nakayama, Masayuki Shimoda
- Organizer
  第80回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16555
[Presentation] 胃底腺型胃癌は、αGlcNAc糖鎖修飾の不十分な未熟腺頸部粘液細胞の形質を主に有する腫瘍である2021
- Author(s)
  山ノ井一裕, 山田重徳, 中山淳
- Organizer
  第110回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K16555
[Presentation] Phenotypic change of gastric gland mucin is a malignant potential biomarker for stomach, pancreas, bile duct and uterine cervix neoplasms.2021
- Author(s)
  Kazuhiro Yamanoi
- Organizer
  Manchester Pathology 2021, 13th Joint meeting of the BDIAP and The Pathological Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16555
[Presentation] Significance of aGlcNAc expression in biliary ductal cancer progression2020
- Author(s)
  山ノ井　一裕, 奥村　征大, 上原　剛, 尾島　英知, 中山　淳
- Organizer
  第109回　日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K16555
[Presentation] 子宮頸部細胞診で胃型粘液性癌が疑われた通常型内頸部腺癌の一例2019
- Author(s)
  服部守恭, 藤井真一, 山ノ井一裕, 中山淳, 福島万奈, 的場久典
- Organizer
  第58回日本臨床細胞学会秋期大会
- Data Source
  KAKENHI-PROJECT-19K16555
[Presentation] 胃腺粘液産生子宮頸部腫瘍におけるαGlcNAcとα4GnTの発現意義2019
- Author(s)
  山ノ井一裕, 井田耕一, 浅香志穂, 竹内穂高, 宮本強, 塩沢丹里, 中山淳
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K16555
[Presentation] Significance of αGlcNAc expression during progression of cholangiocarcinoma2019
- Author(s)
  Motohiro Okumura, Kazuhiro Yamanoi, Jun Nakayama
- Organizer
  The 78th Annual Meeting of the Japanese Cancer Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16555
[Presentation] αGlcNAcとα4GnTは子宮頸部胃型腫瘍の有用な予後マーカーとなる2018
- Author(s)
  井田　耕一、山ノ井　一裕、浅香　志穂、竹内　穂高、宮本　強、塩沢　丹里、中山　淳
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15640
[Presentation] 胃腺粘液産生子宮頸部腫瘍におけるαGlcNAcの発現の意義2018
- Author(s)
  山ノ井　一裕、浅香　志穂、石井　恵子、中山　淳
- Organizer
  第107回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K15640
[Presentation] 早期分化型胃癌における癌抑制分子、TFF1とαGlcNAcの関与2018
- Author(s)
  福島　万奈、川久保　雅友、山田　重徳、山ノ井　一裕、中山　淳
- Organizer
  第107回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K15640
[Presentation] Significance of alpha GlcNAc expression during progression of pancreatic cancer2017
- Author(s)
  Kazuhiro Yamanoi, Ayumu Ohya, Chifumi Fujii and Jun Nakayama
- Organizer
  The 76th Annual meeting of the Japanese Cancer Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15640
[Presentation] 胃・膵臓の幽門腺型粘液産生腫瘍におけるαGlcNAc発現低下とその意義2017
- Author(s)
  山ノ井　一裕、大彌　歩、下條　久志、中山　淳
- Organizer
  第106回日本病理学会
- Data Source
  KAKENHI-PROJECT-17K15640

1. Nakayama Jun

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
2. Fujii Chifumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. Ohya Ayumu

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. Ida Koichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Ishii Keiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. Asaka Shiho

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. Shimojo Hisashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. Miyamoto Tsutomu

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. Shiozawa Tanri

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 川久保雅友

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamanoi Kazuhiro 山ノ井 一裕

Research Projects

Research Products

Co-Researchers

幽門腺型粘液の糖鎖に注目したがん抑制機構の解明と、早期がん診断への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Significance of reduced alphaGlcNAc glycosylation in pyloric gland neoplasmsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Significance of alphaGlcNAc expression status in human tumorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Decreased expression of TFF2 and decreased αGlcNAc glycosylation are malignant biomarkers of pyloric gland adenoma of the duodenum2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 多段階発癌過程における幽門腺粘液の糖鎖修飾の変化とその臨床病理学的意義2023

Author(s)

Journal Title

Data Source

[Journal Article] MUC6 expression is a preferable prognostic marker for invasive mucinous adenocarcinoma of the lung2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glycosylation of MUC6 by α1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decreased alpha‐1,4‐linked N‐acetylglucosamine glycosylation in biliary tract cancer progression from biliary intraepithelial neoplasia to invasive adenocarcinoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diffuse MIST1 expression and decreased α1,4‐linked N‐acetylglucosamine (αGlcNAc) glycosylation on MUC6 are distinct hallmarks for gastric neoplasms showing oxyntic gland differentiation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] αGlcNAc and its catalyst α4GnT are diagnostic and prognostic markers in uterine cervical tumor, gastric type2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of A4gnt Knockout Mice Reveals an Essential Role for Gastric Sulfomucins in Preventing Gastritis Cystica Profunda2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gastric gland mucin-specific O-glycan expression decreases as tumor cells progress from lobular endocervical gland hyperplasia to cervical mucinous carcinoma, gastric type2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] αGlcNAc glycosylation on gastric gland mucin is a biomarker of malignant potential for gastric cancer, Barrett’s adenocarcinoma, and pancreatic cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gastric gland mucin-specific O-glycan expression decreases with tumor progression from precursor lesions to pancreatic cancer2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] 幽門腺型粘液の糖鎖修飾は、胃、膵・胆道、子宮頸部、肺において早期癌マーカーとなり得るのみならず、癌の悪性化にも関わる2024

Author(s)

Organizer

Data Source

Yamanoi Kazuhiro 山ノ井一裕

[Presentation] MUC6 expression is a novel preferable prognostic marker for　invasive mucinous adenocarcinoma of the lung.2021