Morikawa Takayuki 森川隆之

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Takayuki Morikawa 森川隆之

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Researcher Number	80465012
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立国際医療研究所, 上級研究員
Affiliation (based on the past Project Information) *help	2023 – 2024: 国立研究開発法人国立国際医療研究センター, その他部局等, 上級研究員 2016 – 2023: 国立研究開発法人国立国際医療研究センター, その他部局等, 研究員 2015: 慶應義塾大学, 医学部, 講師(非常勤)
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Neurosurgery
Keywords	Principal Investigator 造血幹細胞 / 酸素 / 微小循環 / ニッチ / 生体イメージング / 骨髄 / 脳血流代謝 / 一酸化炭素

加齢性造血幹細胞生着不全を惹起する骨髄微小環境要因の探索Principal Investigator
- Principal Investigator
  
  森川隆之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  National Center for Global Health and Medicine
The mechanisms of regulation of oxygen concentration to maintain hematopoiesis in bone marrowPrincipal Investigator
- Principal Investigator
  
  Morikawa Takayuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  National Center for Global Health and Medicine
Elucidation of aging process of bone marrow niche by intravital imagingPrincipal Investigator
- Principal Investigator
  
  Morikawa Takayuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  National Center for Global Health and Medicine
Protective effects of endogenous carbon monoxide on cerebral energy metabolism during acute focal brain ischemiaPrincipal Investigator
- Principal Investigator
  
  Takayuki Morikawa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  National Center for Global Health and Medicine
  Keio University

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Quantitative Analysis of Sympathetic and Nociceptive Innervation Across Bone Marrow Regions in Mice2022
- Author(s)
  Fujita Shinya、Morikawa Takayuki、Tamaki Shinpei、Sezaki Maiko、Takizawa Hitoshi、Okamoto Shinichiro、Kataoka Keisuke、Takubo Keiyo
- Journal Title
  
  Experimental Hematology
  
  Volume: 112-113 Pages: 44-59
- DOI
  10.1016/j.exphem.2022.07.297
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08383, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-21H02957
[Journal Article] p38α plays differential roles in hematopoietic stem cell activity dependent on aging contexts2021
- Author(s)
  Sorimachi Yuriko、Karigane Daiki、Ootomo Yukako、Kobayashi Hiroshi、Morikawa Takayuki、Otsu Kinya、Kubota Yoshiaki、Okamoto Shinichiro、Goda Nobuhito、Takubo Keiyo
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 296 Pages: 100563-100563
- DOI
  10.1016/j.jbc.2021.100563
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21621, KAKENHI-PROJECT-18K08379, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-19K17877, KAKENHI-PROJECT-21K08383, KAKENHI-PROJECT-20K07345
[Journal Article] Identification and local manipulation of bone marrow vasculature during intravital imaging2020
- Author(s)
  Morikawa Takayuki、Tamaki Shinpei、Fujita Shinya、Suematsu Makoto、Takubo Keiyo
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 6422-6422
- DOI
  10.1038/s41598-020-63533-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-18K08379
[Journal Article] Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses2019
- Author(s)
  Nagai M、Noguchi R、Takahashi D、Morikawa T、Koshida K、Komiyama S、Ishihara N、Yamada T、Kawamura YI.、Muroi K、Hattori K、Kobayashi N、Fujimura Y、Hirota M、Matsumoto R、Aoki R、Tamura-Nakano M、Sugiyama M、Katakai T、Sato S、Takubo K、Dohi T、Hase K
- Journal Title
  
  Cell
  
  Volume: 178 Issue: 5 Pages: 1072-1087
- DOI
  10.1016/j.cell.2019.07.047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08379, KAKENHI-PROJECT-19K22528, KAKENHI-PROJECT-19K22532, KAKENHI-PUBLICLY-18H04680, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-17KT0055, KAKENHI-PROJECT-18K19570, KAKENHI-PLANNED-18H05417
[Journal Article] Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo.2019
- Author(s)
  Kobayashi H, Morikawa T, Okinaga A, Hamano F, Hashidate-Yoshida T, Watanuki S, Hishikawa D, Shindou H, Arai F, Kabe Y, Suematsu M, Shimizu T, Takubo K.
- Journal Title
  
  Cell Reports
  
  Volume: 28 Issue: 1 Pages: 145-158
- DOI
  10.1016/j.celrep.2019.06.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06921, KAKENHI-PROJECT-18K08379, KAKENHI-PROJECT-19K22638, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-17H04208, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-18K19570
[Journal Article] Potential involvement of semaphorin 3A in maintaining intervertebral disc tissue homeostasis2019
- Author(s)
  Mima Y, Suzuki S, Fujii T, Morikawa T, Tamaki S, Takubo K, Shimoda M, Miyamoto T, Watanabe K, Matsumoto M, Nakamura M, Fujita N.
- Journal Title
  
  J Orthop Res
  
  Volume: 37 Issue: 4 Pages: 972-980
- DOI
  10.1002/jor.24258
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02930, KAKENHI-PROJECT-18K08379, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-18K19570
[Journal Article] Quantitative imaging mass spectroscopy reveals roles of heme oxygenase-2 for protecting against transhemispheric diaschisis in the brain ischemia2018
- Author(s)
  1.Shinichi Goto, Takayuki Morikawa, Akiko Kubo, Keiyo Takubo, Keiichi Fukuda, Mayumi Kajimura, Makoto Suematsu
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 63 Issue: 1 Pages: 70-79
- DOI
  10.3164/jcbn.17-136
- NAID
  130007387127
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07066, KAKENHI-PROJECT-15K10315, KAKENHI-PROJECT-16K19425, KAKENHI-PROJECT-18K08379
[Journal Article] Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival2018
- Author(s)
  Shiota M, Naya M, Yamamoto T, Hishiki T, Tani T, Takahashi H, Kubo A, Koike D, Itoh M, Ohmura M, Kabe Y, Sugiura Y, Hiraoka N, Morikawa T, Takubo K, Suina K, Nagashima H, Sampetrean O, Nagano O, Saya H, Yamazoe S, Watanabe H, Suematsu M
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1561-1561
- DOI
  10.1038/s41467-018-03899-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-15H04355, KAKENHI-PROJECT-15K07011, KAKENHI-PROJECT-15K10315, KAKENHI-PROJECT-18K06921, KAKENHI-PROJECT-18K08379, KAKENHI-PROJECT-17K19614, KAKENHI-PROJECT-16K07124, KAKENHI-PROJECT-18J14396
[Journal Article] Abnormal hematopoiesis and hematopoietic stem cell niche2017
- Author(s)
  田久保圭誉、森川隆之、小林央
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 58 Issue: 10 Pages: 1844-1850
- DOI
  10.11406/rinketsu.58.1844
- NAID
  130006132651
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16200, KAKENHI-PLANNED-26115005, KAKENHI-PROJECT-15H04861, KAKENHI-PROJECT-15K10315, KAKENHI-PROJECT-16K15507
[Journal Article] The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(-)2016
- Author(s)
  Tsuchihashi K, Okazaki S, Ohmura M, Ishikawa M, Sampetrean O, Onishi N, Wakimoto H, Yoshikawa M, Seishima R, Iwasaki Y, Morikawa T, Abe S, Takao A, Shimizu M, Masuko T, Nagane M, Furnari FB, Akiyama T, Suematsu M, Baba E, Akashi K, Saya H, Nagano O.
- Journal Title
  
  Cancer Research
  
  Volume: in press Issue: 10 Pages: 2954-2963
- DOI
  10.1158/0008-5472.can-15-2121
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10315, KAKENHI-PROJECT-14J06883, KAKENHI-PROJECT-25462277, KAKENHI-PROJECT-16K07125, KAKENHI-PROJECT-16K18454
[Journal Article] Hypoxia regulates the hematopoietic stem cell niche.2016
- Author(s)
  Morikawa T, Takubo K.
- Journal Title
  
  Pflugers Arch.
  
  Volume: 468 Issue: 1 Pages: 13-22
- DOI
  10.1007/s00424-015-1743-z
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-26115005, KAKENHI-PROJECT-15H04861, KAKENHI-PROJECT-15K10315
[Journal Article] Leukocyte plugging and cortical capillary flow after subarachnoid hemorrhage2016
- Author(s)
  Ishikawa M., Kajimura M., Morikawa T., Tsukada K., Tsuji T., Kusaka G., Tanaka Y., Suematsu M.
- Journal Title
  
  Acta Neurochirurgica
  
  Volume: - Issue: 6 Pages: 1057-1067
- DOI
  10.1007/s00701-016-2792-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26560221, KAKENHI-PROJECT-15K10315, KAKENHI-PROJECT-16K07066
[Journal Article] Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K.2016
- Author(s)
  Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 19 Issue: 2 Pages: 192-204
- DOI
  10.1016/j.stem.2016.05.013
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111003, KAKENHI-PLANNED-26115003, KAKENHI-PLANNED-26115005, KAKENHI-PROJECT-26221303, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15H04851, KAKENHI-PROJECT-15H04861, KAKENHI-PROJECT-15K10315, KAKENHI-PROJECT-16K15507
[Presentation] Intravital imaging and manipulation of bone marrow vasculature and intracellular oxygenation2021
- Author(s)
  Takayuki Morikawa and Keiyo Takubo
- Organizer
  The International Society for Experimental Hematology 50th Annual Scientific Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08383
[Presentation] PHYSIOLOGICAL HYPOXIA MAINTAINED BY NITRIC OXIDE SIGNALING REGULATES LOCAL CRAWLING OF HEMATOPOIETIC STEM CELLS2021
- Author(s)
  Takayuki Morikawa, Shinya Fujita and Keiyo Takubo
- Organizer
  International Society for Stem Cell Research / The Japanese Society for Regenerative Medicine 2021 Tokyo International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08383
[Presentation] Nitric oxide-dependent vasodilation maintains the physiological oxygen levels in bone marrow and allows local crawling of hematopoietic stem cells2021
- Author(s)
  Takayuki Morikawa and Keiyo Takubo
- Organizer
  The International Society for Experimental Hematology 50th Annual Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08383
[Presentation] Age-related alteration in nitric oxide signaling attenuates arrival of transplanted hematopoietic stem/progenitor cells to bone marrow2018
- Author(s)
  Takayuki Morikawa、Keiyo Takubo
- Organizer
  幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-18K08379
[Presentation] Aging impairs NO-mediated migration of transplanted hematopoietic stem/progenitors to bone marrow2018
- Author(s)
  Takayuki Morikawa、Keiyo Takubo
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-18K08379
[Presentation] Deletion of heme oxygenase-2 exacerbates cerebral energy metabolism during acute focal brain ischemia2015
- Author(s)
  森川隆之、梶村眞弓、後藤信一、星野岳郎、善岡尊文、久保亜紀子、杉浦八十男、菱木貴子、末松誠
- Organizer
  The 10th World Congress for Microcirculation
- Place of Presentation
  国立京都国際会館(京都府左京区）
- Year and Date
  2015-09-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10315

1. TAKUBO Keiyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. GODA Nobuhito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. MIYAMOTO Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 末松誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 塚田孝祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 加部泰明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 菱木貴子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Morikawa Takayuki 森川 隆之

Takayuki Morikawa 森川 隆之

Research Projects

Research Products

Co-Researchers

加齢性造血幹細胞生着不全を惹起する骨髄微小環境要因の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanisms of regulation of oxygen concentration to maintain hematopoiesis in bone marrowPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of aging process of bone marrow niche by intravital imagingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Protective effects of endogenous carbon monoxide on cerebral energy metabolism during acute focal brain ischemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Quantitative Analysis of Sympathetic and Nociceptive Innervation Across Bone Marrow Regions in Mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] p38α plays differential roles in hematopoietic stem cell activity dependent on aging contexts2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification and local manipulation of bone marrow vasculature during intravital imaging2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Potential involvement of semaphorin 3A in maintaining intervertebral disc tissue homeostasis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Quantitative imaging mass spectroscopy reveals roles of heme oxygenase-2 for protecting against transhemispheric diaschisis in the brain ischemia2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Gold-nanof&egrave;ve surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Abnormal hematopoiesis and hematopoietic stem cell niche2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

Morikawa Takayuki 森川隆之

Takayuki Morikawa 森川隆之

[Journal Article] Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival2018