NAKAI Yousuke 中井陽介

… Alternative Names

Nakai Yousuke 中井陽介

Less

Researcher Number	80466755
Other IDs
Affiliation (Current)	2025: 東京女子医科大学, 医学部, 教授 2025: 東京大学, 医学部附属病院, 病院診療医(出向)
Affiliation (based on the past Project Information) *help	2024: 東京女子医科大学, 医学部, 教授 2018 – 2023: 東京大学, 医学部附属病院, 准教授 2017: 東京大学, 医学部附属病院, その他 2014 – 2017: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 50010:Tumor biology-related / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology / Tumor biology
Keywords	Principal Investigator 膵癌 / オルガノイド / 膵臓癌 / エピジェネテイクス / 液-液相分離 / basal型膵癌 / エピジェネティクス / 膵がん / KDM6B Except Principal Investigator 膵癌 … More / トランスクリプトーム / サブタイプ / 予後解析 / 分子病理疫学 / 微小環境 / ヒト / ヒストン / クロマチン / エピゲノム / エピジェネテイクス / 膵がん / VCAM-1 / バイオマーカー / 化学療法 / 膵臓癌 Less

相分離に基づく転写制御機構を標的とした膵癌分子サブタイプ特異的治療法の開発Principal Investigator
- Principal Investigator
  
  中井陽介
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokyo Women's Medical University
Analysis of the mechanism in remodeling of pancreatic tumor microenvironment by epigenetic modificationPrincipal Investigator
- Principal Investigator
  
  Nakai Yousuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Analysis of transcriptome in the tumor microenvironment to explore the pathogenesis and new treatment strategies of human pancreatic cancer.
- Principal Investigator
  
  Hamada Tsuyoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Analysis of histone modification in patient-derived pancreatic cancer cells.Principal Investigator
- Principal Investigator
  
  Nakai Yousuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Analysis of histone modification system that governs the progression of pancreatic oncogenesis
- Principal Investigator
  
  TATEISHI KEISUKE
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Identification of a molecular marker relating to the progression of pancreatic cancer cellsPrincipal Investigator
- Principal Investigator
  
  Nakai Yousuke
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
膵癌の治療奏功性・抵抗性におけるVCAM-1の機能解析と臨床における有用性
- Principal Investigator
  
  高橋良太
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2015

All Journal Article

[Journal Article] Clinical Outcomes of Intraductal Papillary Mucinous Neoplasms With Dilatation of the Main Pancreatic Duct2023
- Author(s)
  Hamada Tsuyoshi、Oyama Hiroki、Nakai Yousuke、Tateishi Keisuke、Ushiku Tetsuo、Hasegawa Kiyoshi、Fujishiro Mitsuhiro
- Journal Title
  
  Clinical Gastroenterology and Hepatology
  
  Volume: - Issue: 7 Pages: 792-1801
- DOI
  10.1016/j.cgh.2023.01.032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07886, KAKENHI-PROJECT-22K15958, KAKENHI-PROJECT-20K08324, KAKENHI-PROJECT-20K08353, KAKENHI-PROJECT-22K06976, KAKENHI-PROJECT-23K07392
[Journal Article] KRAS variant allele frequency, but not mutation positivity, associates with survival of patients with pancreatic cancer2022
- Author(s)
  Suzuki T, Masugi Y, Inoue Y, Hamada T, Tanaka M, Takamatsu M, Arita J, Kato T, Kawaguchi Y, Kunita A, Nakai Y, Nakano Y, Ono Y, Sasahira N, Takeda T, Tateishi K, Uemura S, Koike K, Ushiku T, Takeuchi K, Sakamoto M, Hasegawa K, Kitago M, Takahashi Y, Fujishiro M.
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 9 Pages: 3097-3109
- DOI
  10.1111/cas.15398
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08362, KAKENHI-PROJECT-20K07414, KAKENHI-PROJECT-21K07886, KAKENHI-PROJECT-22K06976, KAKENHI-PROJECT-20K07422
[Journal Article] MNX1-HNF1B Axis Is Indispensable for Intraductal Papillary Mucinous Neoplasm Lineages2022
- Author(s)
  Kato H, Tateishi K, Fujiwara H, Nakatsuka T, Yamamoto K, Kudo Y, Hayakawa Y, Nakagawa H, Tanaka Y, Ijichi H, Otsuka M, Iwadate D, Oyama H, Kanai S, Noguchi K, Suzuki T, Sato T, Hakuta R, Ishigaki K, Saito K, Saito T, Takahara N, Kishikawa T, Hamada T, Takahashi R, Miyabayashi K, et al.
- Journal Title
  
  Gastroenterology
  
  Volume: 162 Issue: 4 Pages: 1272-1287
- DOI
  10.1053/j.gastro.2021.12.254
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08362, KAKENHI-PROJECT-19K08435, KAKENHI-PROJECT-19K16533, KAKENHI-PROJECT-20K08353, KAKENHI-PROJECT-21K07886, KAKENHI-PROJECT-21K07935, KAKENHI-PROJECT-20K16154, KAKENHI-PROJECT-21K15368, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-21K07906, KAKENHI-PROJECT-22K06976, KAKENHI-PROJECT-20K08324, KAKENHI-PROJECT-21K15966
[Journal Article] HNF1B‐driven three‐dimensional chromatin structure for molecular classification in pancreatic cancers2022
- Author(s)
  Kato Hiroyuki、Tateishi Keisuke、Iwadate Dosuke、Yamamoto Keisuke、Fujiwara Hiroaki、Nakatsuka Takuma、Kudo Yotaro、Hayakawa Yoku、Ijichi Hideaki、Otsuka Motoyuki、Kishikawa Takahiro、Takahashi Ryota、Miyabayashi Koji、Nakai Yousuke、Hirata Yoshihiro、Toyoda Atsushi、Morishita Shinichi、Fujishiro Mitsuhiro
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 4 Pages: 1672-1685
- DOI
  10.1111/cas.15690
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19517, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H02893, KAKENHI-PROJECT-21K15966, KAKENHI-PROJECT-23K07350, KAKENHI-PROJECT-21K07886, KAKENHI-PROJECT-21K07907, KAKENHI-PROJECT-23K24314
[Journal Article] ABO Blood Group and Risk of Pancreatic Carcinogenesis in Intraductal Papillary Mucinous Neoplasms2021
- Author(s)
  Hamada T, Oyama H, Nakai Y, Tada M, Koh H, Tateishi K, Arita J, Hakuta R, Ijichi H, Ishigaki K, Kawaguchi Y, Kogure H, Mizuno S, Morikawa T, Saito K, Saito T, Sato T, Takagi K, Takahara N, Takahashi R, Tanaka A, Tanaka M, Ushiku T, Hasegawa K, Koike K.
- Journal Title
  
  Cancer Epidemiology, Biomarkers and Prevention
  
  Volume: 30 Issue: 5 Pages: 1020-1028
- DOI
  10.1158/1055-9965.epi-20-1581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08362, KAKENHI-PROJECT-19K08387
[Journal Article] Soluble VCAM-1 promotes gemcitabine resistance via macrophage infiltration and predicts therapeutic response in pancreatic cancer2020
- Author(s)
  Takahashi Ryota、Ijichi Hideaki、Sano Makoto、Miyabayashi Koji、Mohri Dai、Kim Jinsuk、Kimura Gen、Nakatsuka Takuma、Fujiwara Hiroaki、Yamamoto Keisuke、Kudo Yotaro、Tanaka Yasuo、Tateishi Keisuke、Nakai Yousuke、Morishita Yasuyuki、Soma Katsura、Takeda Norihiko、Moses Harold L.、Isayama Hiroyuki、Koike Kazuhiko
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41598-020-78320-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07584, KAKENHI-PROJECT-20K08398, KAKENHI-PROJECT-18K07961, KAKENHI-PROJECT-18K07962, KAKENHI-PROJECT-18K15880
[Journal Article] A phase II trial of gemcitabine, S-1 and LV combination (GSL) therapy in patients with advanced pancreatic cancer.2019
- Author(s)
  Saito K, Isayama H, Nakai Y, Takahara N, Ishigaki K, Hamada T, Mizuno S, Sasaki T, Kogure H, Matsubara S, Yamamoto N, Ijichi H, Tateishi K, Tada M, Koike K.
- Journal Title
  
  Invest New Drugs.
  
  Volume: 37 Pages: 338-344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07962
[Journal Article] Diagnostic yield of the plasma free amino acid index for pancreatic cancer in patients with diabetes mellitus2019
- Author(s)
  Mizuno Suguru、Isayama Hiroyuki、Nakai Yousuke、Ishigaki Kazunaga、Saito Kei、Sato Tatsuya、Takeda Tsuyoshi、Hakuta Ryunosuke、Saito Tomotaka、Takahara Naminatsu、Kogure Hirofumi、Ijichi Hideaki、Tateishi Keisuke、Tada Minoru、Shikata Nahoko、Tagami Tomoyuki、Koike Kazuhiko
- Journal Title
  
  Pancreatology
  
  Volume: 19 Issue: 5 Pages: 695-698
- DOI
  10.1016/j.pan.2019.07.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16533, KAKENHI-PROJECT-18K07962
[Journal Article] A phase II trial of gemcitabine, S-1 and LV combination (GSL) neoadjuvant chemotherapy for patients with borderline resectable and locally advanced pancreatic cancer2018
- Author(s)
  Saito Kei、Isayama Hiroyuki、Sakamoto Yoshihiro、Nakai Yousuke、Ishigaki Kazunaga、Tanaka Mariko、Watadani Takeyuki、Arita Junichi、Takahara Naminatsu、Mizuno Suguru、Kogure Hirofumi、Ijichi Hideaki、Tateishi Keisuke、Tada Minoru、Hasegawa Kiyoshi、Fukayama Masashi、Kokudo Norihiro、Koike Kazuhiko
- Journal Title
  
  Medical Oncology
  
  Volume: 35 Issue: 7 Pages: 100-100
- DOI
  10.1007/s12032-018-1158-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09454, KAKENHI-PROJECT-18K07962, KAKENHI-PROJECT-16K09390
[Journal Article] Isocitrate dehydrogenase 1 mutation sensitizes intrahepatic cholangiocarcinoma to the BET inhibitor JQ12018
- Author(s)
  Fujiwara Hiroaki、Tateishi Keisuke、Kato Hiroyuki、Nakatsuka Takuma、Yamamoto Keisuke、Tanaka Yasuo、Ijichi Hideaki、Takahara Naminatsu、Mizuno Suguru、Kogure Hirofumi、Matsubara Saburo、Nakai Yousuke、Koike Kazuhiko
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 11 Pages: 3602-3610
- DOI
  10.1111/cas.13784
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07899, KAKENHI-PROJECT-18K07961, KAKENHI-PROJECT-18K07962, KAKENHI-PROJECT-16K09342, KAKENHI-PROJECT-16K09390, KAKENHI-PROJECT-16K09391
[Journal Article] A phase II trial of gemcitabine, S-1 and LV combination (GSL) therapy in patients with advanced pancreatic cancer2018
- Author(s)
  Saito K、Isayama H、Nakai Y、Takahara N、Ishigaki K、Takeda T、Hakuta R、Saito T、Uchino R、Kishikawa T、Hamada T、Mizuno S、Sasaki T、Kogure H、Matsubara S、Yamamoto N、Ijichi H、Tateishi K、Tada M、Koike K
- Journal Title
  
  Investigational New Drugs
  
  Volume: 37 Issue: 2 Pages: 338-344
- DOI
  10.1007/s10637-018-0691-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09390, KAKENHI-PROJECT-16K09391
[Journal Article] Prevalence of Pancreatic Cystic Lesions Is Associated With Diabetes Mellitus and Obesity: An Analysis of 5296 Individuals Who Underwent a Preventive Medical Examination.2017
- Author(s)
  Mizuno S, Isayama H, Nakai Y, Yoshikawa T, Ishigaki K, Matsubara S, Yamamoto N, Ijichi H, Tateishi K, Tada M, Hayashi N, Koike K.
- Journal Title
  
  Pancreas
  
  Volume: 46 Issue: 6 Pages: 801-805
- DOI
  10.1097/mpa.0000000000000833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09041, KAKENHI-PROJECT-16K09390
[Journal Article] Thromboembolisms in Advanced Pancreatic Cancer: A Retrospective Analysis of 475 Patients.2017
- Author(s)
  Ishigaki K(1), Nakai Y, Isayama H, Saito K, Hamada T, Takahara N, Mizuno S, Mohri D, Kogure H, Matsubara S, Yamamoto N, Tada M, Koike K.
- Journal Title
  
  Pancreas
  
  Volume: 46 Issue: 8 Pages: 1069-1075
- DOI
  10.1097/mpa.0000000000000889
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09038, KAKENHI-PROJECT-15K09042
[Journal Article] The Role of Pancreatic Enzyme Replacement Therapy in Unresectable Pancreatic Cancer: A Prospective CohortStudy2017
- Author(s)
  Saito T, Hirano K, Isayama H, Nakai Y, Saito K, Umefune G, Akiyama D, Watanabe T, Takagi K, Hamada T, Takahara N, Uchino R, Mizuno S, Kogure H, Matsubara S, Yamamoto N, Tada M, Koike K.
- Journal Title
  
  Dig Endosc
  
  Volume: 46 Issue: 3 Pages: 341-346
- DOI
  10.1097/mpa.0000000000000767
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09042
[Journal Article] The inhibition of renin-angiotensin system in advanced pancreatic cancer: an exploratory analysis in 349 patients2015
- Author(s)
  Nakai Y, Isayama H, Sasaki T, Takahara N, Saito K, Ishigaki K, Hamada T, Mizuno S, Miyabayashi K, Yamamoto K, Mohri D, Kogure H, Yamamoto N, Ijichi H, Tateishi K, Tada M, Koike K.
- Journal Title
  
  J Cancer Res Clin Oncol.
  
  Volume: 144 Issue: 5 Pages: 933-939
- DOI
  10.1007/s00432-014-1873-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09042

1. TATEISHI KEISUKE (20396948)

# of Collaborated Projects: 5 results

# of Collaborated Products: 10 results
2. 高橋良太 (80647660)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 山本恵介 (10608532)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. Hamada Tsuyoshi (90723461)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 伊地知秀明 (70463841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 松原三郎 (40750550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 水野卓 (30771050)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 藤原弘明 (00814500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 多田稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 高原楠昊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 岸川孝弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 木暮宏史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 山本夏代

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 石垣和祥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAKAI Yousuke 中井 陽介

Nakai Yousuke 中井 陽介

Research Projects

Research Products

Co-Researchers

相分離に基づく転写制御機構を標的とした膵癌分子サブタイプ特異的治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the mechanism in remodeling of pancreatic tumor microenvironment by epigenetic modificationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of transcriptome in the tumor microenvironment to explore the pathogenesis and new treatment strategies of human pancreatic cancer.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of histone modification in patient-derived pancreatic cancer cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of histone modification system that governs the progression of pancreatic oncogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of a molecular marker relating to the progression of pancreatic cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

膵癌の治療奏功性・抵抗性におけるVCAM-1の機能解析と臨床における有用性

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Clinical Outcomes of Intraductal Papillary Mucinous Neoplasms With Dilatation of the Main Pancreatic Duct2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] KRAS variant allele frequency, but not mutation positivity, associates with survival of patients with pancreatic cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MNX1-HNF1B Axis Is Indispensable for Intraductal Papillary Mucinous Neoplasm Lineages2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HNF1B‐driven three‐dimensional chromatin structure for molecular classification in pancreatic cancers2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ABO Blood Group and Risk of Pancreatic Carcinogenesis in Intraductal Papillary Mucinous Neoplasms2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Soluble VCAM-1 promotes gemcitabine resistance via macrophage infiltration and predicts therapeutic response in pancreatic cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A phase II trial of gemcitabine, S-1 and LV combination (GSL) therapy in patients with advanced pancreatic cancer.2019

Author(s)

Journal Title

NAKAI Yousuke 中井陽介

Nakai Yousuke 中井陽介