MOTOJIMA MASARU 本島英

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Motojima Masaru 本島英

MOTOJIMA Masaru 本島英

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Researcher Number	80468636
Other IDs
Affiliation (Current)	2025: 東海大学, 医学部, 客員准教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 東海大学, 医学部, 准教授 2010 – 2017: 東海大学, 医学部, 講師 2015: 東海大学, 医学部・薬理学, 講師 2008: 東海大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / Kidney internal medicine Except Principal Investigator Kidney internal medicine
Keywords	Principal Investigator Foxc2 / Foxc1 / エリスロポエチン産生細胞 / 腎発生 / フォークヘッド転写因子 / 糸球体硬化 / 転写因子 / ポドサイト / ヒトiPS細胞 / 分化誘導 … More / 成人型エリスロポエチン産生細胞 / 腎間質細胞 / 腎性貧血 / iPS細胞分化誘導 / ストローマ / Foxc1/2 / 前駆細胞 / 貧血 / ネフロン前駆細胞 / 腎間質前駆細胞 / ネフロン発生 / ポドサイト傷害 / 尿タンパク / フォークヘッド / 分化 / 糸球体傷害 / 腎尿路形成異常 / 腎臓学 … More Except Principal Investigator トランスジェニックマウス / 糸球体硬化症 / 慢性腎不全 / ポドサイト / CAKUT / 性差 / コラーゲン / 慢性腎臓病 / アンジオテンシン / タンパク尿 / ポドサイト傷害 / コンディショナル・ターゲッティング / SV40T / VEGF / Megalin / Cre-loxPシステム / ノックアウトマウス / 糸球体上皮細胞 / GIV-1 / キメラマウス / megalin / SV40 / Angiotensin II / 蛋白尿 / レニン・アンギオテンシン / 細胞周期 Less

Induction of adult type erythropoietin producing cellPrincipal Investigator
- Principal Investigator
  
  本島英
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Tokai University
Roles of Foxc1/2 in nephron developmentPrincipal Investigator
- Principal Investigator
  
  Motojima Masaru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Tokai University
Foxc1/2 transcription factors and glomerulosclerosisPrincipal Investigator
- Principal Investigator
  
  MOTOJIMA Masaru
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokai University
Novel Approach for Treatment of Glomeruloclerosis
- Principal Investigator
  
  ICHIKAWA Iekuni
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokai University
Roles of Foxc transcription factors in podocyte injury.Principal Investigator
- Principal Investigator
  
  MOTOJIMA Masaru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokai University
glomerular sclerosis
- Principal Investigator
  
  ICHIKAWA Iekuni
- Project Period (FY)
  2004 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokai University

All 2022 2017 2016 2015 2013 2011 2009 2008 2007 2006 2005 Other

All Journal Article Presentation

[Journal Article] <i>Foxc1</i> and <i>Foxc2</i> are indispensable for the maintenance of nephron and stromal progenitors in the developing kidney2022
- Author(s)
  Motojima Masaru、Tanaka Masayuki、Kume Tsutomu
- Journal Title
  
  Journal of Cell Science
  
  Volume: 135 Issue: 19
- DOI
  10.1242/jcs.260356
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08364, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-19K22665
[Journal Article] Foxc1 and Foxc2 are necessary to maintain glomerular podocytes2017
- Author(s)
  Masaru Motojima, Tsutomu Kume, Taiji Matsusaka
- Journal Title
  
  Exp Cell Res
  
  Volume: 352 Issue: 2 Pages: 265-272
- DOI
  10.1016/j.yexcr.2017.02.016
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461234
[Journal Article] Characterization of Kidney and Skeleton Phenotypes of Mice Double Heterozygous for Foxc1 and Foxc22016
- Author(s)
  Motojima M, Tanimoto S, Ohtsuka M, Matsusaka T, Kume T, Abe K
- Journal Title
  
  Cells Tissues Organs
  
  Volume: 201 Issue: 5 Pages: 380-389
- DOI
  10.1159/000445027
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461234
[Journal Article] Characterization of kidney and skeleton phenotypes of mice double-heterozygous for Foxc1 and Foxc22016
- Author(s)
  Masaru Motojima, Sho Tanimoto, Masato Otsuka, Taiji Matsusaka, Tsutomu Kume , Koichiro Abe
- Journal Title
  
  Cells Tissues Organs
  
  Volume: In Press
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461234
[Journal Article] Conditional knockout of Foxc2 gene in kidney: efficient generation of conditional alleles of single-exon gene by double-selection system2016
- Author(s)
  Motojima, Masaru; Ogiwara, Sanae; Matsusaka, Taiji; Kim, Sang Yong; Sagawa, Nobuho; Abe, Koichiro; Ohtsuka, Masato
- Journal Title
  
  Mamm Genome
  
  Volume: 27 Issue: 1-2 Pages: 62-69
- DOI
  10.1007/s00335-015-9610-y
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461234, KAKENHI-PROJECT-23249047, KAKENHI-PROJECT-25290035
[Journal Article] Foxc1 gene null mutation causes ectopic budding and kidney hypoplasia but not dysplasia.2013
- Author(s)
  Komaki F,Miyazaki Y, Niimura F,Mtsusaka T, Ichikawa I,Motojima M .
- Journal Title
  
  Cells Tissues Organs.
  
  Volume: 198・1 Issue: 1 Pages: 22-27
- DOI
  10.1159/000351291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249033, KAKENHI-PROJECT-23249047, KAKENHI-PROJECT-23591202, KAKENHI-PROJECT-25461234
[Journal Article] Fibrinogen That Appear in the Bowman's Space of Proteinuric Kidneys in vivo Activates Podocyte Toll-like Receptor 2 and 4 in vitro.2009
- Author(s)
  Motojima M, Matsusaka T, Kon V, Ichikawa I.
- Journal Title
  
  Nephron Experimental. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16109005
[Journal Article] Fibrinogen That Appear in the Bowman's Space of Proteinuric Kidneys in vivo Activates Podocyte Toll-like Receptor 2 and 4 in vitro.2009
- Author(s)
  Motojima M, Matsusaka T, Kon V, Ichikawa I.
- Journal Title
  
  Nephron Experimental (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16109005
[Journal Article] Angiotensin inhibition decreases progression of advanced atherosclerosis and stabilizes established atherosclerotic plaques.2007
- Author(s)
  Suganuma E, Babaev VR, Motojima M, Zuo Y, Ayabe N, Fogo AB, Ichikawa I, Linton MF, Fazio S, Kon V.
- Journal Title
  
  J Am Soc Nephrol. 18(8)
  
  Pages: 2311-2319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16109005
[Journal Article] Podocyte damage damages podocytes : autonomous vicious cycle that drives local spread of glomerular sclerosis.2005
- Author(s)
  Ichikawa I, Ma J, Motojima M, Matsusaka T.
- Journal Title
  
  Curr Opin Nephrol Hypertens. 14(3)
  
  Pages: 205-210
- Data Source
  KAKENHI-PROJECT-16109005
[Journal Article] Foxc1 gene null mutation causes ectopic budding and kidney hypoplasia, but not dysplasia
- Author(s)
  Komaki, F.; Miyazaki, Y.; Niimura, F.; Matsusaka, T.; Ichikawa, I.; Motojima, M.
- Journal Title
  
  CELLS TISSUES ORGANS
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590899
[Presentation] Forkhead transcription factors, Foxc1 and Foxc2, regulate podocyte gene expression.2016
- Author(s)
  Motojima M, Kume T, Matsusaka T
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-25461234
[Presentation] Foxc1とFoxc2はポドサイトの成熟と維持に必須である2016
- Author(s)
  本島英、松阪泰二
- Organizer
  第25回発達腎研究会
- Place of Presentation
  聖路加臨床学術センター（東京都中央区）
- Year and Date
  2016-08-27
- Data Source
  KAKENHI-PROJECT-25461234
[Presentation] Forkhead transcription factors, Foxc1 and Foxc2, are required to maintain glomerular architecture.2015
- Author(s)
  Masaru Motojima,Tsutomu Kume, Taiji Matsusaka
- Organizer
  第38回日本分子生物学会年会／第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸国際展示場(兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25461234
[Presentation] Ectopic Ureteral Budding from the Wolffian Duct Results in Hypoplastic, But Not Dysplastic, Kidney2011
- Author(s)
  本島英
- Organizer
  米国腎臓学会年会
- Place of Presentation
  フィラデルフィア
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-22590899
[Presentation] Ectopic ureteral budding from the wolffian duct results in hypoplastic, but not dysplastic, kidney2011
- Author(s)
  発表者:本島英、小牧文代、宮崎陽一、新村文男、松阪泰二、市川家國
- Organizer
  米国腎臓学会年会
- Place of Presentation
  フィラデルフィア
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-22590899
[Presentation] Nephrin Gene Expression in Podocytes Is Regulated by Histone Acetylation.2008
- Author(s)
  Motojima M, Matsusaka T, Kon V, Ichikawa I.
- Organizer
  American Society of Nephrology Renal Week 2008 Annual Meeting.
- Place of Presentation
  Philadelphia.
- Data Source
  KAKENHI-PROJECT-16109005
[Presentation] Nephrin Gene Expression in Podocytes Is Regulated by Histone Acetylation.2008
- Author(s)
  Motojima M, Matsusaka T, Kon V, Ichikawa l
- Organizer
  ASN Annual Meeting2008
- Place of Presentation
  米国・フィラデルフィア
- Data Source
  KAKENHI-PROJECT-16109005
[Presentation] Identification of Activators of Nephrin Gene Promoter.2007
- Author(s)
  Motojima M, Matsusaka T, Kon V, Ichikawa I.
- Organizer
  American Society of Nephrology Renal Week 2007 Annual Meeting.
- Place of Presentation
  San Francisco.
- Data Source
  KAKENHI-PROJECT-16109005
[Presentation] Identification of Activators of Nephrin Gene Promoter.2007
- Author(s)
  Motojima M, Matsusaka T, Kon V, Ichikawa I
- Organizer
  ASN Annual Meeting 2007
- Place of Presentation
  米国・サンフランシスコ
- Data Source
  KAKENHI-PROJECT-16109005
[Presentation] Toll-like receptors in podocytes modulate response to injury.2006
- Author(s)
  Motojima M, Matsusaka T, Ichikawa I.
- Organizer
  American Society of Nephrology Renal Week 2006 Annual Meeting.
- Place of Presentation
  San Diego.
- Data Source
  KAKENHI-PROJECT-16109005
[Presentation] Efficient generation of conditional alleles in a single-exon gene locus by a double-selection system in mice.
- Author(s)
  Masaru Motojima, Iekuni Ichikawa, Taiji Matsusaka, Masato Ohtsuka.
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25461234
[Presentation] Foxc1 and Foxc2 cooperate in maintaining glomerular podocytes.
- Author(s)
  Masaru Motojima, Tsutomu Kume, Taiji Matsusaka, Iekuni Ichikawa.
- Organizer
  Experimental Biology (EB) 2015
- Place of Presentation
  Boston
- Year and Date
  2015-03-28 – 2015-04-01
- Data Source
  KAKENHI-PROJECT-25461234
[Presentation] Foxc1とFoxc2の腎発生における役割
- Author(s)
  本島英、市川家國
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸国際展示場
- Data Source
  KAKENHI-PROJECT-25461234

1. MATSUSAKA Taiji (50317749)

# of Collaborated Projects: 5 results

# of Collaborated Products: 19 results
2. ICHIKAWA Iekuni (80317768)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
3. MIYAZAKI Yoichi (60266690)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. NIIMURA Fumio (30282750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. NAGATA Michio (10192238)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OHTSUKA Masato (90372945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. Pastan Ira

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MOTOJIMA MASARU 本島 英

Motojima Masaru 本島 英

MOTOJIMA Masaru 本島 英

Research Projects

Research Products

Co-Researchers

Induction of adult type erythropoietin producing cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of Foxc1/2 in nephron developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Foxc1/2 transcription factors and glomerulosclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel Approach for Treatment of Glomeruloclerosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of Foxc transcription factors in podocyte injury.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

glomerular sclerosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] <i>Foxc1</i> and <i>Foxc2</i> are indispensable for the maintenance of nephron and stromal progenitors in the developing kidney2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Foxc1 and Foxc2 are necessary to maintain glomerular podocytes2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of Kidney and Skeleton Phenotypes of Mice Double Heterozygous for Foxc1 and Foxc22016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of kidney and skeleton phenotypes of mice double-heterozygous for Foxc1 and Foxc22016

Author(s)

Journal Title

Data Source

[Journal Article] Conditional knockout of Foxc2 gene in kidney: efficient generation of conditional alleles of single-exon gene by double-selection system2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Foxc1 gene null mutation causes ectopic budding and kidney hypoplasia but not dysplasia.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fibrinogen That Appear in the Bowman's Space of Proteinuric Kidneys in vivo Activates Podocyte Toll-like Receptor 2 and 4 in vitro.2009

Author(s)

Journal Title

Data Source

[Journal Article] Fibrinogen That Appear in the Bowman's Space of Proteinuric Kidneys in vivo Activates Podocyte Toll-like Receptor 2 and 4 in vitro.2009

Author(s)

Journal Title

Data Source

[Journal Article] Angiotensin inhibition decreases progression of advanced atherosclerosis and stabilizes established atherosclerotic plaques.2007

MOTOJIMA MASARU 本島英

Motojima Masaru 本島英

MOTOJIMA Masaru 本島英