Toyota Hiroko 豊田博子

… Alternative Names

TOYOTA Hiroko 豊田博子

豊田博子トヨタヒロコ

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Researcher Number	80468660
Other IDs
Affiliation (Current)	2025: 東京医科大学, 医学部, 助手
Affiliation (based on the past Project Information) *help	2024: 東京医科大学, 医学部, 助手 2014 – 2020: 東京医科大学, 医学部, 助手 2011: 東京医科大学, 医学部, 助手 2009: 東京医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Experimental pathology Except Principal Investigator Biomedical engineering/Biomaterial science and engineering / Pathobiological dentistry/Dental radiology / Surgical dentistry
Keywords	Principal Investigator CD8 T細胞 / 腫瘍免疫 / LAG-3 / 病理学 / ストレス応答性MAPキナーゼ / ストストレス応答性MAPキナーゼ / ストレス応答MAPキナーゼ / ストレス応答MAPキナーゼJNK Except Principal Investigator 口腔扁平上皮癌 / がんワクチン … More / ナノ粒子 / ガンワクチン / 癌幹細胞 / 転移 / 癌 / ナノバイオ / 免疫学 / ワクチン / 免疫 / がん / CTL / ナノテクノロジー / 樹状細胞 / 炎症 / 扁平上皮癌 / 治療戦略 / 細胞死 / 薬剤耐性 Less

抗腫瘍免疫応答における抑制性補助刺激分子LAG-3の「負」と「正」の役割の解明Principal Investigator
- Principal Investigator
  
  豊田博子
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical University
Study of nano particle cancer vaccines targeting for Dendritic cells.
- Principal Investigator
  
  Yanase Noriko
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Tokyo Medical University
Mechanism of allergic inflammation induction of MAP kinase JNKPrincipal Investigator
- Principal Investigator
  
  Toyota Hiroko
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Medical University
Control of antigen-specific immune response by nanoparticles and elucidation of its cellular mechanism
- Principal Investigator
  
  Yanase Noriko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Tokyo Medical University
Role of inflammation in the initiation and development of oral squamous cell carcinoma
- Principal Investigator
  
  MIZUGUCHI Junichiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Tokyo Medical University
口腔扁平上皮癌の化学療法剤耐性及び転移能獲得における細胞死関連分子の役割
- Principal Investigator
  
  納冨武則
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Tokyo Medical University
Characterization of cancer stem cells for oral squamous cell carcinoma cells and its application for treatment of oral carcinoma
- Principal Investigator
  
  MIZUGUCHI Junichiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Tokyo Medical University

All 2019 2018 2016 2015 2014 2012 2009 Other

All Journal Article Presentation

[Journal Article] The Multifaceted Role of PD-1 in Health and Disease2016
- Author(s)
  Badr MEISG, Hata K, Furuhata M, Toyoda H, Yokosuka T.
- Journal Title
  
  Choronic Inflammation
  
  Volume: 1 Pages: 441-457
- DOI
  10.1007/978-4-431-56068-5_34
- ISBN
  9784431560661, 9784431560685
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-16H06495, KAKENHI-PLANNED-16H06501, KAKENHI-PROJECT-16K08746, KAKENHI-INTERNATIONAL-16K21731
[Journal Article] Thy28 protects against anti-CD3-mediated thymic cell death in vivo.2015
- Author(s)
  Toyota H, Sudo K, Kojima K, Yanase N, Nagao T, Takahashi RH, Iobe H, Kuwabara T, Kakiuchi T, and Mizuguchi J.
- Journal Title
  
  Apoptosis
  
  Volume: 20 Issue: 4 Pages: 444-54
- DOI
  10.1007/s10495-014-1082-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592841, KAKENHI-PROJECT-25460600
[Journal Article] Vaccination with OVA-bound nanoparticles enhancing IL-7 inhibits the growth of OVA-expressing E.G7 tumor cells in vivo.2015
- Author(s)
  Toyota H, Yanase N, Yoshimoto T, Harada M, Kato Y, and Mizuguchi J
- Journal Title
  
  Onco Rep
  
  Volume: 33 Issue: 1 Pages: 292-6
- DOI
  10.3892/or.2014.3603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592841, KAKENHI-PROJECT-26350516
[Journal Article] OVA-bound nanoparticles induce OVA-specific IgG1, IgG2a, and IgG2b responses with low IgE synthesis.2014
- Author(s)
  Yanase N, Toyota H, Yagyu S, Seki T, Harada M, Kato Y, and Mizuguchi J
- Journal Title
  
  Vaccine
  
  Volume: 32 Issue: 45 Pages: 5918-24
- DOI
  10.1016/j.vaccine.2014.08.059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592841, KAKENHI-PROJECT-26350516
[Journal Article] Thy28 partially prevents apoptosis induction following engagement of membrane immunoglobulin in WEHI-231 B lymphoma cells.2012
- Author(s)
  Toyota H, Jiang XZ, Asakura H, and Mizuguchi J
- Journal Title
  
  Cell Mol Biol Lett
  
  Volume: 17 Issue: 1 Pages: 36-48
- DOI
  10.2478/s11658-011-0034-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592841
[Journal Article] Thy28 partially prevents apoptosis induction following engagement of membrane immunoglobulin in WEHI-231 B lymphoma cells2012
- Author(s)
  Toyota H, Jiang X, Asakura H, Mizuguchi J
- Journal Title
  
  Cell Mol Biol Lett
  
  Volume: 17 Pages: 36-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592564
[Journal Article] Tumor necrosis factor-related apoptosis-inducing ligand induces apoptotic cell death through c-Jun NH2-teriminal kinase activation in squamous cell carcinoma cells2009
- Author(s)
  Noutomi T, Itoh M, Toyota H, Takada E, and Mizuguchi J
- Journal Title
  
  Oncol Rep
  
  Volume: 22 Pages: 1169-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592564
[Journal Article] Tumor necrosis factor-related apoptosis-inducing ligand induces apoptoric cell death through c-Jun NH2-terminal kinase activation in squamous cell carcinoma cells.2009
- Author(s)
  Noutomi T, Itoh M, Toyota H, Takada E., Mizuguchi J.
- Journal Title
  
  Oncol Rep 22(5)
  
  Pages: 1169-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592564
[Presentation] Indirect suppression of CD4+ T cell activation by LAG3-mediated trogocytosis of MHC Class II2019
- Author(s)
  Wakamatsu E, Machiyama H, Toyota H, Furuhata M, Hata K, Yanase N, Yokosuka T
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08746
[Presentation] Extrinsic and intrinsic inhibition of T cell response by co-inhibitory receptors, TIGIT and CD962019
- Author(s)
  Yanase Noriko, Machiyama Hiroaki, Toyota Hiroko, Furuhata Masae, Hata Kikumi, Takehara Tomohiro, Wakamatsu Ei, Yokosuka Tadashi
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08746
[Presentation] Dynamics of the PI3K signaling pathway induced by a T cell costimulator, ICOS2018
- Author(s)
  Tadashi Yokosuka, Ei Wakamatsu, Noriko Yanase, Hiroko Toyota, Masae Furuhata, Kikumi Hata, Hiroaki Machiyama
- Organizer
  第47回日本免疫学会
- Data Source
  KAKENHI-PROJECT-16K08746
[Presentation] A novel micellar nanoparticles functions as an adjuvant to enhance anti-tumor immune responses in vivo2015
- Author(s)
  Yanase Noriko、Toyota　Hiroko, , Harada　Mitsunori, Mizuguchi Junichiro, Hata Kikumi,Yokosuka Takashi
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌市
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26350516
[Presentation] Thy28 regulates anti-CD3-induced thymocyte death in vivo2012
- Author(s)
  Toyota H, Yanase N, Mizuguchi J
- Organizer
  Proceedings of the Japanese Society for Immunology
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24592841
[Presentation] Antigen on nanoparticles enhances anti-tumor immune responses as well as humoral antibody
- Author(s)
  Mizuguchi J, Toyota H, Yanase N, Yoshimoto T, Harada M, and Kato Y.
- Organizer
  4th International Conference on Vaccines & Vaccination
- Place of Presentation
  Valencia, Spain
- Year and Date
  2014-09-24 – 2014-09-26
- Data Source
  KAKENHI-PROJECT-24592841
[Presentation] Antigen on nanoparticles enhances anti-tumor immune responses as well as humoral antibody responses
- Author(s)
  Junichiro Mizuguchi, Hiroko Toyota, Noriko Yanase,Takayuki Yoshimoto, Mitsunori Harada, Yasuki Kato
- Organizer
  4th International Conference on Vaccines & Vaccination
- Place of Presentation
  Valencia, Spain
- Year and Date
  2014-09-24 – 2014-09-26
- Data Source
  KAKENHI-PROJECT-26350516
[Presentation] Nanoparticles function as adjuvant to enhance anti-tumor immune responses as well as humoral antibody responses in vivo.
- Author(s)
  Toyota H, Yanase N, Yoshimoto T, Harada M, and Mizuguchi J.
- Organizer
  第４３回日本免疫学会総会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24592841
[Presentation] Nanoparticles function as adjuvant to enhance anti-tumor immune responses as well as humoral antibody responses in vivo
- Author(s)
  Toyota　Hiroko, Yanase Noriko、Yoshimoto　Takayuki , Harada　Mitsunori, Mizuguchi Junichiro
- Organizer
  第4３回日本免疫学会学術集会
- Place of Presentation
  京都市
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26350516
[Presentation] ミセル化ナノ粒子によるガンワクチンの開発
- Author(s)
  矢那瀬紀子、豊田博子、秦喜久美、原田充訓、横須賀忠、水口純一郎
- Organizer
  第２６回日本生体防御学会学術総会
- Place of Presentation
  東京
- Year and Date
  2015-07-10 – 2015-07-12
- Data Source
  KAKENHI-PROJECT-26350516

1. HATA Kikumi (30287156)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
2. YANASE Noriko (10210303)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
3. TAKADA Eiko (50110903)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. MIZUGUCHI Junichiro (20150188)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
5. SATOMI Takashi (70276921)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. FURUHATA Masae (90468661)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. CHIBA Hiroshige (80105478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MATSUO Akira (70229417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. WATANABE Masato (40349460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KATAHIRA Takashi (20626642)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 納冨武則 (40459590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 若松英 (40632617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 横須賀忠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Toyota Hiroko 豊田 博子

TOYOTA Hiroko 豊田 博子

豊田 博子 トヨタ ヒロコ

Research Projects

Research Products

Co-Researchers

抗腫瘍免疫応答における抑制性補助刺激分子LAG-3の「負」と「正」の役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of nano particle cancer vaccines targeting for Dendritic cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of allergic inflammation induction of MAP kinase JNKPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Control of antigen-specific immune response by nanoparticles and elucidation of its cellular mechanism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of inflammation in the initiation and development of oral squamous cell carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

口腔扁平上皮癌の化学療法剤耐性及び転移能獲得における細胞死関連分子の役割

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization of cancer stem cells for oral squamous cell carcinoma cells and its application for treatment of oral carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The Multifaceted Role of PD-1 in Health and Disease2016

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Thy28 protects against anti-CD3-mediated thymic cell death in vivo.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vaccination with OVA-bound nanoparticles enhancing IL-7 inhibits the growth of OVA-expressing E.G7 tumor cells in vivo.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] OVA-bound nanoparticles induce OVA-specific IgG1, IgG2a, and IgG2b responses with low IgE synthesis.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Thy28 partially prevents apoptosis induction following engagement of membrane immunoglobulin in WEHI-231 B lymphoma cells.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Thy28 partially prevents apoptosis induction following engagement of membrane immunoglobulin in WEHI-231 B lymphoma cells2012

Author(s)

Journal Title

Data Source

[Journal Article] Tumor necrosis factor-related apoptosis-inducing ligand induces apoptotic cell death through c-Jun NH2-teriminal kinase activation in squamous cell carcinoma cells2009

Author(s)

Toyota Hiroko 豊田博子

TOYOTA Hiroko 豊田博子

豊田博子トヨタヒロコ