terashima minoru 寺島農

… Alternative Names

寺島農テラシマミノル

Terashima Minoru 寺島農

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Researcher Number	80507434
Other IDs
Affiliation (Current)	2025: 熊本大学, 国際先端医学研究機構, 特定事業研究員
Affiliation (based on the past Project Information) *help	2025: 熊本大学, 国際先端医学研究機構, 特定事業研究員 2023: 金沢大学, がん進展制御研究所, 博士研究員 2022: 金沢大学, がん進展制御研究所, 助教 2014 – 2020: 金沢大学, がん進展制御研究所, 助教
Review Section/Research Field	Principal Investigator General medical chemistry / Basic Section 54010:Hematology and medical oncology-related / Basic Section 50010:Tumor biology-related / Basic Section 43010:Molecular biology-related
Keywords	Principal Investigator EMT / 上皮間葉転換 / PRC2 / ポリコーム抑制複合体 / lncRNA / 長鎖非コードRNA / がん悪性化機構 / がん細胞の悪性化 / 薬剤抵抗性 / DNA修復 … More / EMT転写因子 / ヒストンメチル化修飾 / 遺伝子発現制御 / エピジェネティック調節因子 / 長鎖非コードRNA (lncRNA) / 上皮間葉転換（EMT) / ヒストンメチル化 / レトロウイルス挿入変異 / non-coding RNA / エピジェネティクス / 癌 Less

早期老化過程における造血幹細胞のクロマチン動態解析Principal Investigator
- Principal Investigator
  
  寺島農
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kumamoto University
The dynamic epigenetic domain identifies a novel transcription factor that regulates cancer cell progressionPrincipal Investigator
- Principal Investigator
  
  寺島農
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kanazawa University
Search and function elucidation of lncRNAs that regulate epithelial-mesenchymal transitionPrincipal Investigator
- Principal Investigator
  
  Terashima Minoru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Kanazawa University
Functional analysis of long noncoding RNAs that regulate epithelial-mesenchymal transitionPrincipal Investigator
- Principal Investigator
  
  Terashima Minoru
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kanazawa University
The role of non-coding RNA in cancer initiation and cancer progressionPrincipal Investigator
- Principal Investigator
  
  Terashima Minoru
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General medical chemistry
- Research Institution
  Kanazawa University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book

[Book] Epigenetics and Dermatology2015
- Author(s)
  Qianjin Lu, Christopher C. Chang, Bruce C. Richardson, Yu Liu, Jieyue Liao, Jeung-Hoon Lee, Bin Liu, Xin Sheng Wang, Hui-Min Chen, M. Eric Gershwin, Patrick S.C. Leung, Haijing Wu, Christian M. Hedrich, Alexander Lo, Melissa Serravallo, Yixing Han, Jianke Ren, Weishi Yu, Kathrin Muegge, Minoru Terashima, et al.
- Total Pages
  520
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-26893093
[Journal Article] Development of UTX-143, a selective sodium-hydrogen exchange subtype 5 inhibitor, using amiloride as a lead compound2024
- Author(s)
  Shinohara Yusei、Komiya Yuki、Morimoto Kashin、Endo Yoshio、Terashima Minoru、Suzuki Takeshi、Takino Takahisa、Ninomiya Itasu、Yamada Hisatsugu、Uto Yoshihiro
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume: 99 Pages: 117603-117603
- DOI
  10.1016/j.bmc.2024.117603
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07147, KAKENHI-PROJECT-21K07118
[Journal Article] ASH2L, a COMPASS core subunit, is involved in the cell invasion and migration of triple-negative breast cancer cells through the epigenetic control of histone H3 lysine 4 methylation2023
- Author(s)
  Batbayar Gerelsuren、Ishimura Akihiko、Lyu Hanbing、Wanna-udom Sasithorn、Meguro-Horike Makiko、Terashima Minoru、Horike Shin-ichi、Takino Takahisa、Suzuki Takeshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 669 Pages: 19-29
- DOI
  10.1016/j.bbrc.2023.05.061
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06880, KAKENHI-PROJECT-22K06896, KAKENHI-PROJECT-22K07146, KAKENHI-PROJECT-22K07147, KAKENHI-PROJECT-21K07118
[Journal Article] m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF--induced epithelial-mesenchymal transition of lung cancer cells.2022
- Author(s)
  Suphakhong K, Terashima M, Wanna-Udom S, Takatsuka R, Ishimura A, Takino T, Suzuki T.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 11 Pages: 102554-102554
- DOI
  10.1016/j.jbc.2022.102554
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07118, KAKENHI-PROJECT-22K06880, KAKENHI-PROJECT-22K07146, KAKENHI-PROJECT-22K07147
[Journal Article] KDM2B is involved in the epigenetic regulation of TGF-β-induced epithelial-mesenchymal transition in lung and pancreatic cancer cell lines2021
- Author(s)
  Wanna-Udom Sasithorn、Terashima Minoru、Suphakhong Kusuma、Ishimura Akihiko、Takino Takahisa、Suzuki Takeshi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 296 Pages: 100213-100213
- DOI
  10.1074/jbc.ra120.015502
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06057, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-19K07346, KAKENHI-PROJECT-19K07686, KAKENHI-PROJECT-21K07118
[Journal Article] The m6A Methyltransferase METTL3 Contributes to Transforming Growth Factor-beta-induced Epithelial-Mesenchymal Transition of Lung Cancer Cells Through the Regulation of JUNB2020
- Author(s)
  Wanna-udom Sasithorn、Terashima Minoru、Hanbing Lyu、Ishimura Akihiko、Takahisa Takino、Matomo Sakari、Toshifumi Tsukahara、Suzuki Takeshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 524 Issue: 1 Pages: 150-155
- DOI
  10.1016/j.bbrc.2020.01.042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06057, KAKENHI-PROJECT-19K07686, KAKENHI-PROJECT-17H02204, KAKENHI-PROJECT-18K19288, KAKENHI-PROJECT-18K19289, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-19K07346
[Journal Article] Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer2020
- Author(s)
  Wang Rong、Yamada Tadaaki、Kita Kenji、Taniguchi Hirokazu、Arai Sachiko、Fukuda Koji、Terashima Minoru、Ishimura Akihiko、Nishiyama Akihiro、Tanimoto Azusa、Takeuchi Shinji、Ohtsubo Koshiro、Wang Wei、Suzuki Takeshi、Yano Seiji et. al.
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 4607-4607
- DOI
  10.1038/s41467-020-18442-4
- NAID
  120007186801
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07346, KAKENHI-PROJECT-19K07686, KAKENHI-PROJECT-19K22578, KAKENHI-PROJECT-20K22837, KAKENHI-PROJECT-19H03433, KAKENHI-PROJECT-19H03499, KAKENHI-PROJECT-19H03665, KAKENHI-PROJECT-18K06057, KAKENHI-PROJECT-18K08141, KAKENHI-PROJECT-16H06279
[Journal Article] Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion2020
- Author(s)
  Sakai Katsuya、Nishiuchi Takumi、Tange Shoichiro、Suzuki Yoshinori、Yano Seiji、Terashima Minoru、Suzuki Takeshi、Matsumoto Kunio
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 16678-16678
- DOI
  10.1038/s41598-020-72448-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07346, KAKENHI-PROJECT-20K06553, KAKENHI-PROJECT-19H03499, KAKENHI-PROJECT-18K06057
[Journal Article] MEG8 long noncoding RNA contributes to epigenetic progression of the epithelial-mesenchymal transition of lung and pancreatic cancer cells2018
- Author(s)
  Terashima Minoru、Ishimura Akihiko、Wanna-udom Sasithorn、Suzuki Takeshi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 47 Pages: 18016-18030
- DOI
  10.1074/jbc.ra118.004006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06057
[Journal Article] Epigenetic regulation of epithelial-mesenchymal transition by KDM6A histone demethylase in lung cancer cells.2017
- Author(s)
  Terashima M, Ishimura A, Wanna-Udom S and Suzuki T
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 490 Issue: 4 Pages: 1407-13
- DOI
  10.1016/j.bbrc.2017.07.048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08263, KAKENHI-PROJECT-16K19030
[Journal Article] MEG3 long noncoding RNA contributes to the epigenetic regulation of epithelial-mesenchymal transition in lung cancer cell lines.2017
- Author(s)
  Terashima M, Tange S, Ishimura A and Suzuki T.
- Journal Title
  
  J Biol. Chem.
  
  Volume: 292(1) Issue: 1 Pages: 82-99
- DOI
  10.1074/jbc.m116.750950
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08263, KAKENHI-PROJECT-16K19030
[Journal Article] DOT1L histone methyltransferase regulates the expression of BCAT1 and is involved in sphere formation and cell migration of breast cancer cell lines.2016
- Author(s)
  Oktyabri D, Ishimura A, Tange S, Terashima M, Suzuki T.
- Journal Title
  
  Biochimie
  
  Volume: 123 Pages: 20-31
- DOI
  10.1016/j.biochi.2016.01.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460266, KAKENHI-PROJECT-15K08263, KAKENHI-PROJECT-16K19030
[Journal Article] Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.2016
- Author(s)
  Ishimura A, Terashima M, Tange S and Suzuki T.
- Journal Title
  
  Cell Tissue Res.
  
  Volume: 363 Issue: 3 Pages: 723-33
- DOI
  10.1007/s00441-015-2276-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08263, KAKENHI-PROJECT-26893093, KAKENHI-PROJECT-25460266
[Journal Article] Effect of high fat diet on paternal sperm histone distribution and male offspring liver gene expression.2015
- Author(s)
  Terashima M, Barbour S, Ren J, Yu W, Han Y, Muegge K.
- Journal Title
  
  Epigenetics
  
  Volume: 10 Issue: 9 Pages: 861-871
- DOI
  10.1080/15592294.2015.1075691
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893093
[Journal Article] The ATP binding site of the chromatin remodeling homolog Lsh is required for nucleosome density and de novo DNA methylation at repeat sequences.2015
- Author(s)
  Ren J, Briones V, Barbour S, Yu W, Han Y, Terashima M, Muegge K.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 43 Issue: 3 Pages: 1444-1455
- DOI
  10.1093/nar/gku1371
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26893093
[Journal Article] Genome-wide DNA methylation patterns in LSH mutant reveals de-repression of repeat elements and redundant epigenetic silencing pathways.2014
- Author(s)
  Yu W, McIntosh C, Lister R, Zhu I, Han Y, Ren J, Landsman D, Lee E, Briones V, Terashima M, Leighty R, Ecker JR, Muegge K.
- Journal Title
  
  Genome Res.
  
  Volume: 24 Issue: 10 Pages: 1613-1623
- DOI
  10.1101/gr.172015.114
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26893093
[Journal Article] JARID2 is involved in Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines.2014
- Author(s)
  Tange S, Oktyabri D, Terashima M, Ishimura A and Suzuki T.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 12 Pages: e115684-e115684
- DOI
  10.1371/journal.pone.0115684
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590346, KAKENHI-PROJECT-25460266, KAKENHI-PROJECT-26893093
[Journal Article] CG hypomethylation in Lsh-/- mouse embryonic fibroblasts is associated with de novo H3K4me1 formation and altered cellular plasticity.2014
- Author(s)
  Yu W, Briones V, Lister R, McIntosh C, Han Y, Lee EY, Ren J, Terashima M, Leighty RM, Ecker JR, Muegge K.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 111 Issue: 16 Pages: 5890-5895
- DOI
  10.1073/pnas.1320945111
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26893093
[Journal Article] EED regulates epithelial-mesenchymal transition of cancer cells induced by TGF-beta.2014
- Author(s)
  Oktyabri D, Tange S, Terashima M, Ishimura A and Suzuki T.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 453 Issue: 1 Pages: 124-130
- DOI
  10.1016/j.bbrc.2014.09.082
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590346, KAKENHI-PROJECT-25460266, KAKENHI-PROJECT-26893093
[Presentation] Involvement of a Candidate Transcription Factor for Inducing Epithelial-Mesenchymal Transition in DNA Double-Strand Break Repair2023
- Author(s)
  Terashima M, Suphakhong K, Nishiuchi T, Horike SI, Nishimura T, Tange S, Ishimura A, Suzuki T.
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K07147
[Presentation] Roles of a candidate for epithelial-mesenchymal transition-activating transcription factor in cancer cells2022
- Author(s)
  Terashima M, Suphakhong K, Ishimura A, Nishiuchi T, Horike SI, Nishimura T, Tange S, Suzuki T
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K07147
[Presentation] The mechanism of transcriptional regulations controlling epithelial-mesenchymal transition in cancer cells2020
- Author(s)
  1.Terashima M, Ishimura A, Nishimura T, Tange S, Hazawa M, Richard W Wong, Suzuki T.
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06057
[Presentation] Analysis of epithelial-mesenchymal transition-activating transcription factor candidates in cancer cells.2019
- Author(s)
  寺島農, 石村昭彦, 西村建徳, 丹下正一朗, 鈴木健之
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06057
[Presentation] がん細胞の上皮間葉転換を活性化する新たな転写因子の探索2018
- Author(s)
  寺島農, 石村昭彦, 西村建徳, 丹下正一朗, 村田翔, 角崎景南, 鈴木健之
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06057
[Presentation] ヒストンメチル化を指標にした上皮間葉転換を活性化する新規転写因子の探索2018
- Author(s)
  寺島農
- Organizer
  第5回北陸エピジェネティクス研究会
- Data Source
  KAKENHI-PROJECT-18K06057
[Presentation] TGF-βによって誘導される上皮間葉転換のエピジェネティクス制御機構2017
- Author(s)
  寺島農、丹下正一朗、Sasithorn Wanna-udom、石村昭彦、鈴木健之
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K19030
[Presentation] Epigenetic Regulation of Epithelial-Mesenchymal Transition in Cancer Cells.2017
- Author(s)
  Terashima M, Ishimura A, Tange S and Suzuki T.
- Organizer
  The 12th International Symposium of Institute Network
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19030
[Presentation] MEG3長鎖ノンコーディングRNAによる上皮間葉転換のエピジェネティック制御機構2017
- Author(s)
  寺島農
- Organizer
  HOKURIKU RNA CLUB
- Data Source
  KAKENHI-PROJECT-16K19030
[Presentation] 上皮間葉転換におけるポリコーム抑制複合体PRC2を介したエピジェネティック制御機構2016
- Author(s)
  Minoru Terashima
- Organizer
  第3回北陸エピジェネティクス研究会
- Place of Presentation
  福井AOSSA
- Year and Date
  2016-11-21
- Data Source
  KAKENHI-PROJECT-16K19030
[Presentation] 上皮間葉転換におけるPRC2遺伝子発現抑制メカニズム2016
- Author(s)
  Terashima M, Tange S, Ishimura A and Suzuki T.
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K19030
[Presentation] 父親の高脂肪食摂取が自身の精子ヒストンおよび子に及ぼす影響2015
- Author(s)
  寺島農, Barbour Samantha, Ren Jianke, Yu Weishi, Han Yixing, Kathrin Muegge
- Organizer
  第二回北陸エピジェネティクス研究会
- Place of Presentation
  富山大学杉谷キャンパス
- Year and Date
  2015-11-11
- Data Source
  KAKENHI-PROJECT-26893093
[Presentation] JARID2 is involved in TGF-beta-induced epithelial-mesenchymal-transition of cancer cells2015
- Author(s)
  寺島農, 丹下正一朗, Dulamsuren Oktyabri, 石村昭彦, 鈴木健之
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26893093
[Presentation] Paternally transgenerational epigenetic effects on high-fat diet-induced obesity in mice
- Author(s)
  Minoru Terashima, Weishi Yu, Jianke Ren, Yixing Han, Kathrin Muegge
- Organizer
  日本癌学会シンポジウム/共同利用・共同研究拠点シンポジウム
- Place of Presentation
  石川県立音楽堂交流ホール
- Year and Date
  2015-01-21 – 2015-01-22
- Data Source
  KAKENHI-PROJECT-26893093

1. 鈴木健之 (30262075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
2. AKIHIKO Ishimura

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 滝野隆久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

terashima minoru 寺島 農

寺島 農 テラシマ ミノル

Terashima Minoru 寺島 農

Research Projects

Research Products

Co-Researchers

早期老化過程における造血幹細胞のクロマチン動態解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The dynamic epigenetic domain identifies a novel transcription factor that regulates cancer cell progressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search and function elucidation of lncRNAs that regulate epithelial-mesenchymal transitionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of long noncoding RNAs that regulate epithelial-mesenchymal transitionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of non-coding RNA in cancer initiation and cancer progressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Epigenetics and Dermatology2015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Development of UTX-143, a selective sodium-hydrogen exchange subtype 5 inhibitor, using amiloride as a lead compound2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ASH2L, a COMPASS core subunit, is involved in the cell invasion and migration of triple-negative breast cancer cells through the epigenetic control of histone H3 lysine 4 methylation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-&#61538;-induced epithelial-mesenchymal transition of lung cancer cells.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] KDM2B is involved in the epigenetic regulation of TGF-β-induced epithelial-mesenchymal transition in lung and pancreatic cancer cell lines2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The m6A Methyltransferase METTL3 Contributes to Transforming Growth Factor-beta-induced Epithelial-Mesenchymal Transition of Lung Cancer Cells Through the Regulation of JUNB2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MEG8 long noncoding RNA contributes to epigenetic progression of the epithelial-mesenchymal transition of lung and pancreatic cancer cells2018

Author(s)

Journal Title

terashima minoru 寺島農

寺島農テラシマミノル

Terashima Minoru 寺島農

[Journal Article] m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF--induced epithelial-mesenchymal transition of lung cancer cells.2022