TAKASE SATORU 高瀬暁

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高瀬暁タカセサトル

TAKASE Satoru 高瀬暁

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Researcher Number	80508094
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 病院診療医(出向)
Affiliation (based on the past Project Information) *help	2023: 東京大学, 医学部附属病院, 病院診療医(出向) 2022: 東京大学, 医学部附属病院, 助教 2017 – 2020: 東京大学, 医学部附属病院, 助教 2013 – 2015: 東京大学, 医学部附属病院, 助教 2012: 東京大学, 医学部附属病院, その他
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Metabolomics Except Principal Investigator Gastroenterology
Keywords	Principal Investigator APOC2 / hypertriglyceridemia / 高中性脂肪血症 / SNP / monogenic disease / HTG / 動脈硬化 / 遺伝子解析 / 動脈硬化症 / 急性膵炎 … More / 無βリポ蛋白血症 / 高カイロミクロン血症 / MTTP / リポタンパク / リポ蛋白 / 脂質異常症 / whole genome sequence / 原発性脂質異常症 / whole genome sequencing / リポ蛋白リパーゼ / アポリポ蛋白C-II / 全ゲノム解析 / アポﾘﾎﾟ蛋白C-II / rare variant / apoC-II deficiency / chylomicronemia … More Except Principal Investigator 非アルコール性脂肪性肝炎 / リパーゼ / コレステロール / 肝臓学 / 肝癌 / 脂肪性肝炎 / 脂質代謝 / 分子標的 / 炎症 / 脂肪毒性 / 脂肪肝 Less

全エクソーム解析を用いたハイリスク高中性脂肪血症の同定Principal Investigator
- Principal Investigator
  
  高瀬暁
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  The University of Tokyo
Molecular mechanisms and therapeutic targets of severe hypertriglyceridemiaPrincipal Investigator
- Principal Investigator
  
  Takase Satoru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  The University of Tokyo
The physiological roles of intracellular lipases in the pathogenesis of nonalcoholic fatty liver diseases
- Principal Investigator
  
  OKAZAKI Sachiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Exploratory study to identify genetic defects of type I/V hyperlipoproteinemia using Next-Generation SequencingPrincipal Investigator
- Principal Investigator
  
  Takase Satoru
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
The role and molecular mechanisms of free-cholesterol toxicity in steatohepatitis
- Principal Investigator
  
  OKAZAKI Sachiko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Molecular Dissection of hypoapoC-II caused by defective mRNA transcriptionPrincipal Investigator
- Principal Investigator
  
  TAKASE Satoru
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo

All 2023 2018 2013 Other

All Journal Article Presentation

[Journal Article] A novel homozygous nonsense variant of LMF1 in pregnancy-induced hypertriglyceridemia with acute pancreatitis2023
- Author(s)
  Tanaka Masaki、Takase Satoru、Ishiura Hiroyuki、Yamauchi Toshimasa、Okazaki Sachiko、Okazaki Hiroaki
- Journal Title
  
  Journal of Clinical Lipidology
  
  Volume: Online ahead of print Issue: 3 Pages: 327-331
- DOI
  10.1016/j.jacl.2023.03.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21443, KAKENHI-PROJECT-22K08645
[Journal Article] Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene2013
- Author(s)
  Takase S, Osuga J, Fujita H, Hara K, Sekiya M, Igarashi M, Takanashi M, Takeuchi Y, Izumida Y, Ohta K, Kumagai M, Nishi M, Kubota M, Masuda Y, Taira Y, Okazaki S, Iizuka Y, Yahagi N, Ohashi K, Yoshida H, Yanai H, Tada N, Gotoda T, Ishibashi S, Kadowaki T, Okazaki H
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 20 (5) Pages: 481-93
- NAID
  130004444688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790914
[Journal Article] Apolipoprotein C-II Deficiency with No Rare Variant in the <i>APOC2</i> Gene2013
- Author(s)
  Takase S, Osuga J, Fujita H, Hara K, Sekiya M, Igarashi M, Takanashi M, Takeuchi Y, Izumida Y, Ohta K, Kumagai M, Nishi M, Kubota M, Masuda Y, Taira Y, Okazaki S, Iizuka Y, Yahagi N, Ohashi K, Yoshida H, Yanai H, Tada N, Gotoda T, Ishibashi S, Kadowaki T, Okazaki H
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 20 Issue: 5 Pages: 481-493
- DOI
  10.5551/jat.16592
- NAID
  130004444688
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23116006, KAKENHI-PROJECT-24790914
[Presentation] GPIHBP1の蛋白低値と新規変異を認めた小児発症の重度高中性脂肪血症の一例2023
- Author(s)
  田中監督、高瀬暁、石浦浩之、中嶋克行、木村孝穂、村上正巳、石セイセン、高梨幹生、飯塚陽子、辻省次、山内敏正、岡崎佐智子、岡崎啓明
- Organizer
  第55回日本動脈硬化学会
- Data Source
  KAKENHI-PROJECT-22K08645
[Presentation] 脂肪摂取制限が奏功し正常分娩に至った妊娠時の重度高中性脂肪血症性急性膵炎（LMF1ナンセンス変異ホモ接合体）の一例2023
- Author(s)
  田中監督、高瀬暁、石浦浩之、濱野頌子、石セイセン、高梨幹生、飯塚陽子、辻省次、山内敏正、岡崎佐智子、岡崎啓明
- Organizer
  第55回日本動脈硬化学会
- Data Source
  KAKENHI-PROJECT-22K08645
[Presentation] 著明高 G血症の原因遺伝子:APOC2構造変異の探索2018
- Author(s)
  高瀬暁石浦浩之田中督記高梨幹生蔵野信岡崎佐智子木村武史飯塚陽子岡島史宜吉田博原眞純塚本和久辻省次門脇孝岡崎啓明
- Organizer
  第50回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K08467
[Presentation] 著明高TG血症患者におけるhypoapoC-II構造変異2018
- Author(s)
  高瀬暁石浦浩之田中督記高梨幹生蔵野信岡崎佐智子木村武史李騁騁飯塚陽子岡島史宜吉田博澤野文夫原眞純大須賀淳一島野仁辻省次石橋俊門脇孝岡崎啓明
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08467
[Presentation] 蛋白翻訳領域に変異の無い非典型的アポC-II 欠損症の分子生物学的解析2013
- Author(s)
  高瀬暁, 大須賀淳一, 藤田逸人, 原一雄, 高梨幹生, 飯塚陽子, 吉田博, 柳内秀勝, 多田紀夫, 山田信博, 石橋俊, 岡崎啓明, 門脇孝
- Organizer
  第45回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2013-07-18
- Data Source
  KAKENHI-PROJECT-24790914
[Presentation] Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene2013
- Author(s)
  高瀬暁, 大須賀淳一, 藤田逸人, 原一雄, 関谷元博, 五十嵐正樹, 高梨幹生, 武内謙憲, 泉田欣彦, 太田啓介, 熊谷真義, 西真貴子, 久保田みどり, 升田紫, 平美乃, 岡崎佐智子, 飯塚陽子, 矢作直也, 大橋健, 吉田博, 柳井秀勝, 多田紀夫, 後藤田貴也, 石橋俊, 岡崎啓明, 門脇孝
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Year and Date
  2013-05-16
- Data Source
  KAKENHI-PROJECT-24790914
[Presentation] 蛋白翻訳領域に変異の無いapoC-II欠損/低下症の分子生物学的解析2013
- Author(s)
  高瀬暁, 大須賀淳一, 藤田逸人, 原一雄, 高梨幹生, 泉田欣彦, 久保田みどり, 升田紫, 飯塚陽子, 吉田博, 柳内秀勝, 多田紀夫, 山田信博, 石橋俊, 岡崎啓明, 門脇孝
- Organizer
  第34回日本肥満学会
- Place of Presentation
  東京
- Year and Date
  2013-10-12
- Data Source
  KAKENHI-PROJECT-24790914
[Presentation] 全ゲノム解析を用いたapoC-II低下症の原因遺伝子の探索
- Author(s)
  高瀬暁、石浦浩之、三井純、藤田逸人、原一雄、高梨幹生、飯塚陽子、吉田博、大須賀淳一、石橋俊、辻省次、門脇孝、岡崎啓明
- Organizer
  第46回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-26860688
[Presentation] Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene
- Author(s)
  高瀬暁大須賀淳一藤田逸人原一雄関谷元博五十嵐正樹高梨幹生武内謙憲泉田欣彦太田啓介熊谷真義西真貴子久保田みどり升田紫平美乃岡崎佐智子飯塚陽子矢作直也大橋健吉田博柳井秀勝多田紀夫後藤田貴也石橋俊岡崎啓明門脇孝
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  ホテル日航熊本
- Data Source
  KAKENHI-PROJECT-24790914
[Presentation] 蛋白翻訳領域に変異の無いapoC-II欠損／低下症の分子生物学的解析
- Author(s)
  高瀬暁大須賀淳一藤田逸人原一雄高梨幹生泉田欣彦久保田みどり升田紫飯塚陽子吉田博柳内秀勝多田紀夫山田信博石橋俊岡崎啓明門脇孝
- Organizer
  第34回日本肥満学会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-24790914
[Presentation] 蛋白翻訳領域に変異の無い非典型的アポC-II欠損症の分子生物学的解析
- Author(s)
  高瀬暁大須賀淳一藤田逸人原一雄高梨幹生飯塚陽子吉田博柳内秀勝多田紀夫山田信博石橋俊岡崎啓明門脇孝
- Organizer
  第45回日本動脈硬化学会総会・学術集会
- Place of Presentation
  京王プラザホテル
- Data Source
  KAKENHI-PROJECT-24790914
[Presentation] Molecular dissection of hypoapoC-II caused by defective apoC-II mRNA transcription
- Author(s)
  Satoru Takase, Hiroyuki Ishiura, Jun Mitusi, Hayato Fujita, Kazuo Hara, Mikio Takanashi, Jun-ichi Osuga, Shun Ishibashi, Shoji Tsuji, Takashi Kadowaki and Hiroaki Okazaki
- Organizer
  9th Metabolic Syndrome, type II Diabetes and Atherosclerosis congress
- Place of Presentation
  Kyoto
- Year and Date
  2014-09-12 – 2014-09-14
- Data Source
  KAKENHI-PROJECT-26860688
[Presentation] whole genome sequence 解析を用いたapoC-II低下症の原因遺伝子変異同定の試み
- Author(s)
  高瀬暁、石浦浩之、三井純、藤田逸人、原一雄、関谷元博、五十嵐正樹、高梨幹生、泉田欣彦、久保田みどり、升田紫、平美乃、岡崎佐智子、飯塚陽子、矢作直也、大橋健、吉田博、柳内秀勝、多田紀夫、後藤田貴也、大須賀淳一、石橋俊、辻省次、門脇孝、岡崎啓明
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26860688

1. OKAZAKI Sachiko (30648720)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. OKAZAKI Hiroaki (80610211)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. TAKANASHI Mikio (70610799)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KUBOTA Midori (20383804)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAKAHASHI Masafumi (40296108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKASE SATORU 高瀬 暁

高瀬 暁 タカセ サトル

TAKASE Satoru 高瀬 暁

Research Projects

Research Products

Co-Researchers

全エクソーム解析を用いたハイリスク高中性脂肪血症の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms and therapeutic targets of severe hypertriglyceridemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The physiological roles of intracellular lipases in the pathogenesis of nonalcoholic fatty liver diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploratory study to identify genetic defects of type I/V hyperlipoproteinemia using Next-Generation SequencingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role and molecular mechanisms of free-cholesterol toxicity in steatohepatitis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Dissection of hypoapoC-II caused by defective mRNA transcriptionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A novel homozygous nonsense variant of LMF1 in pregnancy-induced hypertriglyceridemia with acute pancreatitis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene2013

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Apolipoprotein C-II Deficiency with No Rare Variant in the <i>APOC2</i> Gene2013

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Presentation] GPIHBP1の蛋白低値と新規変異を認めた小児発症の重度高中性脂肪血症の一例2023

Author(s)

Organizer

Data Source

[Presentation] 脂肪摂取制限が奏功し正常分娩に至った妊娠時の重度高中性脂肪血症性急性膵炎（LMF1ナンセンス変異ホモ接合体）の一例2023

Author(s)

Organizer

Data Source

[Presentation] 著明高 G血症の原因遺伝子:APOC2構造変異の探索2018

Author(s)

Organizer

Data Source

[Presentation] 著明高TG血症患者におけるhypoapoC-II構造変異2018

Author(s)

Organizer

Data Source

[Presentation] 蛋白翻訳領域に変異の無い非典型的アポC-II 欠損症の分子生物学的解析2013

Author(s)

Organizer

Place of Presentation

TAKASE SATORU 高瀬暁

高瀬暁タカセサトル

TAKASE Satoru 高瀬暁