Tsuchiya Hiroyoshi 土屋裕義

… Alternative Names

土屋裕義ツチヤヒロヨシ

TSUCHIYA Hiroyoshi 土屋裕義

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Researcher Number	80508755
Other IDs	https://orcid.org/0000-0002-0871-0344
Affiliation (Current)	2025: 自治医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2025: 自治医科大学, 医学部, 講師 2021 – 2023: 自治医科大学, 医学部, 講師 2018 – 2019: 自治医科大学, 医学部, 講師 2009 – 2014: Jichi Medical University, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / General pharmacology Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Anesthesiology / General pharmacology
Keywords	Principal Investigator オキシトシン受容体 / 分娩 / プロトンポンプ / 不妊症 / pH測定系 / MRI / 着床 / アデノ随伴ウイルス / プロスタグランジン受容体 / RNAi … More / AAV / 早産 / バソプレッシン受容体 / 欠損マウス / バソプレッシンV1a受容体 / in situ hybridization法 / 子宮 / 精巣上体 / V1a受容体 / バソプレッシン / 神経突起 / 性行動 / インドメタシン / 視床下部 / プロスタグランジン / テストステロン / PGE_2 / 中枢・末梢神経 … More Except Principal Investigator 受容体 / バゾプレッシン / 体内時計 / 血液脳関門 / 高齢者 / トランスポーター / 薬物動態 / モルヒネ / 相互作用 / アロステリック効果 / シグナル複合体 / 高次複合体 / バゾプレシン / アレスチン / アデニレートサイクラーゼ / ゲノム編集 / オピオイド / 医療用麻薬 / 鎮痛耐性 / ステロイドホルモン / ノックアウトマウス / 副腎皮質 / リポフスチン Less

非侵襲的な生殖組織pH測定系の構築とそれを用いた不妊症診断・治療法の導出Principal Investigator
- Principal Investigator
  
  土屋裕義
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Jichi Medical University
Prediction of drug disposition into brain in elders using clusters of daily variation in gene expression
- Principal Investigator
  
  藤村昭夫
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Jichi Medical University
Elucidation of the mechanism of V1a receptor-induced uterine contraction via receptor coordination and derivation of therapeutic targets for preterm birthPrincipal Investigator
- Principal Investigator
  
  土屋裕義
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Jichi Medical University
Can we prevent analgesic tolerance to morphine? Study of high-order opioid receptor signal complex and its clinical application.
- Principal Investigator
  
  Koshimizu Taka-aki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology
- Research Institution
  Jichi Medical University
Adverse effects of vasopressin receptor deficiency on the male reproductive defectPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Hiroyoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Jichi Medical University
Drug development using accelerated aging model
- Principal Investigator
  
  KOSHIMIZU Taka-aki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Jichi Medical University
The study of the PGE_2 as a new sexual differentiation factor in the brain.Principal Investigator
- Principal Investigator
  
  TSUCHIYA Hiroyoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Jichi Medical University

All 2024 2023 2022 2021 2020 2018 2017 2015 2012 2011 2010

All Journal Article Presentation

[Journal Article] Vasopressin V1a receptor and oxytocin receptor regulate murine sperm motility differently2023
- Author(s)
  Tsuchiya Hiroyoshi、Fujinoki Masakatsu、Azuma Morio、Koshimizu Taka-aki
- Journal Title
  
  Life Science Alliance
  
  Volume: 6 Issue: 4 Pages: e202201488-e202201488
- DOI
  10.26508/lsa.202201488
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09477, KAKENHI-PROJECT-20K15834
[Journal Article] Pharmacological lineage analysis revealed the binding affinity of broad-spectrum substance P antagonists to receptors for gonadotropin-releasing peptide2015
- Author(s)
  Arai K, Kashiwazaki A, Fujiwara Y, Tsuchiya H, Sakai N, Shibata K, Koshimizu TA3
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 749 Pages: 98-106
- DOI
  10.1016/j.ejphar.2015.01.001
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590327, KAKENHI-PROJECT-24790259
[Journal Article] Chronic ritodrine treatment induces refractoriness of glucose-lowering beta2 adrenoceptor signal in female mice2012
- Author(s)
  Tsuchiya H., et.al.
- Journal Title
  
  Regulatory toxicology and pharmacology
  
  Volume: 62 Issue: 3 Pages: 561-567
- DOI
  10.1016/j.yrtph.2011.11.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590289, KAKENHI-PROJECT-24590327
[Journal Article] 生物系薬学 ♂と♀の脳の違いを"見る"アロマターゼの発現部位の同定2010
- Author(s)
  土屋裕義
- Journal Title
  
  ファルマシア
  
  Volume: 46 Pages: 458-459
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790247
[Journal Article] ♂と♀の脳の違いを"見る"アロマターゼの発現部位の同定2010
- Author(s)
  土屋裕義
- Journal Title
  
  ファルマシア
  
  Volume: 46巻 Pages: 458-459
- URL
  http://farumashia.pharm.or.jp/mokuji/2010/46-05.html
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790247
[Presentation] バソプレッシンV1a受容体の生殖組織における発現分布と欠損マウスの生殖機能異常2024
- Author(s)
  土屋裕義、藤ノ木政勝、藤村翔太、藤原葉子、東森生、輿水崇鏡
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K09477
[Presentation] マウス精巣上体におけるオキシトシン受容体とバソプレッシンV1a受容体の発現比較とアトシバン投与時の精子超活性化の変化2023
- Author(s)
  土屋裕義、藤ノ木政勝、東森生、輿水崇鏡
- Organizer
  第116回日本繁殖生物学会大会
- Data Source
  KAKENHI-PROJECT-21K09477
[Presentation] V1a受容体欠損マウスの産仔数は子宮内での成長異常により減少する2022
- Author(s)
  土屋裕義，東森生，持丸雄太，輿水崇鏡
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K09477
[Presentation] 雄性生殖器におけるV1a受容体の発現分布とV1a受容体欠損マウスの精子運動機能解析2022
- Author(s)
  土屋裕義、藤ノ木政勝、東森生、輿水崇鏡
- Organizer
  第115回日本繁殖生物学会大会
- Data Source
  KAKENHI-PROJECT-21K09477
[Presentation] V1a受容体欠損マウスで観察される産仔数減少とその原因となる胎仔の異常2021
- Author(s)
  土屋裕義，東森生，持丸雄太，輿水崇鏡
- Organizer
  第114回日本繁殖生物学会大会
- Data Source
  KAKENHI-PROJECT-21K09477
[Presentation] オピオイド鎮痛耐性におけるV1bバゾプレッシン受容体複合体の機能解析2020
- Author(s)
  輿水崇鏡、Chortip S、Fujianti C、Nuttawadee N、藤原葉子、東森生、土屋裕義、谷口淳一
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04323
[Presentation] バソプレッシンV1a受容体欠損マウスが示す離乳後の体重減少2020
- Author(s)
  Hiroyoshi Tsuchiya et. al.
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04323
[Presentation] マシンインテリジェンスによるバゾプレシン受容体欠損マウスの表現型解析2018
- Author(s)
  輿水崇鏡、Chortip S、Fujianti C、Nuttawadee N、藤原葉子、東森生、土屋裕義、谷口淳一
- Organizer
  第29回バソプレシン研究会
- Data Source
  KAKENHI-PROJECT-17H04323
[Presentation] 痛みに関わるV1bバゾプレッシン受容体高次複合体の機能解析2018
- Author(s)
  輿水崇鏡、Nuttawadee Ngamlertwong、藤原葉子、土屋裕義、谷口淳一
- Organizer
  バゾプレッシン研究会
- Data Source
  KAKENHI-PROJECT-17H04323
[Presentation] V1a vasopressin receptor involved in the uterus contraction2018
- Author(s)
  Tsuchiya H et. al.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04323
[Presentation] マウス視床下部神経細胞の突起形成へのプロスタグランジンD2 の作用2017
- Author(s)
  土屋裕義、北條寛典、杉本幸彦、Ngamlertwong Nuttawadee、藤原葉子、輿水崇鏡
- Organizer
  日本下垂体研究会学術集会
- Data Source
  KAKENHI-PROJECT-17H04323
[Presentation] EP4受容体を介したPGE2の神経突起伸長促進作用2012
- Author(s)
  土屋裕義, 杉本幸彦, 藤原葉子, 藤村昭夫, 輿水崇鏡
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-21790247
[Presentation] EP4受容体を介したPGE_2の神経突起伸長促進作用2012
- Author(s)
  土屋裕義, 杉本幸彦, 藤原葉子, 藤村昭夫, 輿水崇鏡
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-21790247
[Presentation] プロスタグランジンE_2はEP4受容体を介してマウス視床下部神経細胞の突起伸長を促進する2011
- Author(s)
  土屋裕義, 杉本幸彦, 藤原葉子, 藤村昭夫, 輿水崇鏡
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21790247
[Presentation] プロスタグランジンE2はEP4受容体を介してマウス視床下部神経細胞の突起伸長を促進する2011
- Author(s)
  土屋裕義, 杉本幸彦, 藤原葉子, 藤村昭夫, 輿水崇鏡
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21790247
[Presentation] 視床下部神経細胞の突起伸長に対するPGE_2の作用2010
- Author(s)
  土屋裕義, 杉本幸彦, 藤原葉子, 藤村昭夫, 輿水崇鏡
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21790247
[Presentation] 視床下部神経細胞の突起伸長に対するPGE_2の作用2010
- Author(s)
  土屋裕義, 杉本幸彦, 藤原葉子, 藤村昭夫, 輿水崇鏡
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21790247

1. KOSHIMIZU Taka-aki (20392491)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. 東森生 (90709643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 藤村昭夫 (90156901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 今井靖 (20359631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 牛島健太郎 (70448843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Tsuchiya Hiroyoshi 土屋 裕義

土屋 裕義 ツチヤ ヒロヨシ

TSUCHIYA Hiroyoshi 土屋 裕義

Research Projects

Research Products

Co-Researchers

非侵襲的な生殖組織pH測定系の構築とそれを用いた不妊症診断・治療法の導出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Prediction of drug disposition into brain in elders using clusters of daily variation in gene expression

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of V1a receptor-induced uterine contraction via receptor coordination and derivation of therapeutic targets for preterm birthPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Can we prevent analgesic tolerance to morphine? Study of high-order opioid receptor signal complex and its clinical application.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Adverse effects of vasopressin receptor deficiency on the male reproductive defectPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Drug development using accelerated aging model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of the PGE_2 as a new sexual differentiation factor in the brain.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Vasopressin V1a receptor and oxytocin receptor regulate murine sperm motility differently2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pharmacological lineage analysis revealed the binding affinity of broad-spectrum substance P antagonists to receptors for gonadotropin-releasing peptide2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chronic ritodrine treatment induces refractoriness of glucose-lowering beta2 adrenoceptor signal in female mice2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 生物系薬学 ♂と♀の脳の違いを"見る"アロマターゼの発現部位の同定2010

Author(s)

Journal Title

Data Source

[Journal Article] ♂と♀の脳の違いを"見る"アロマターゼの発現部位の同定2010

Author(s)

Journal Title

URL

Data Source

[Presentation] バソプレッシンV1a受容体の生殖組織における発現分布と欠損マウスの生殖機能異常2024

Author(s)

Organizer

Data Source

[Presentation] マウス精巣上体におけるオキシトシン受容体とバソプレッシンV1a受容体の発現比較とアトシバン投与時の精子超活性化の変化2023

Author(s)

Organizer

Data Source

Tsuchiya Hiroyoshi 土屋裕義

土屋裕義ツチヤヒロヨシ

TSUCHIYA Hiroyoshi 土屋裕義

[Presentation] 雄性生殖器におけるV1a受容体の発現分布とV1a受容体欠損マウスの精子運動機能解析2022