OHTO Takayo 大戸貴代

Researcher Number	80511378
Affiliation (based on the past Project Information) *help	2018: 秋田大学, 医学(系)研究科(研究院), 助教 2013 – 2016: 秋田大学, 医学(系)研究科(研究院), 助教 2013: 秋田大学, 大学院・医学系研究科, 助教 2011 – 2012: 秋田大学, 医学系研究科, 助教 2010 – 2011: 秋田大学, 大学院・医学系研究科, 助教
Review Section/Research Field	Principal Investigator General pharmacology / Emergency medicine Except Principal Investigator General medical chemistry
Keywords	Principal Investigator ２型糖尿病 / 創薬 / LPA4アンタゴニスト / 生理活性脂質 / リゾホスファチジン酸 / ホスホリパーゼA2 / 脂質メタボローム / インフルエンザ / ホスホリパーゼA_2 / 脂質生物学 … More Except Principal Investigator … More LPA / シグナル伝達 / 脂質 / リゾフォスファチジン酸 / 化合物ライブラリー / LPA4 / リゾホスファチジン酸 Less

Biological regulation by Galpha12/13-mediated lipid mediator function
- Principal Investigator
  
  Satoshi Ishii
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Akita University
Lysophosphatidic acid receptor 4 as a potential drug target for the treatment of type 2 diabetesPrincipal Investigator
- Principal Investigator
  
  Ohto-N Takayo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Akita University
Targeting bioactive lipid receptors for drug development
- Principal Investigator
  
  ISHII Satoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Akita University
Regulatory mechanism of lipid mediator metabolism by phospholipaseA2s in influenza virus infectionPrincipal Investigator
- Principal Investigator
  
  OHTO Takayo
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Akita University

All 2018 2017 2015 2010

All Journal Article Presentation

[Journal Article] The Gα12/13-coupled receptor LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity2018
- Author(s)
  Yanagida Keisuke、Igarashi Hidemitsu、Yasuda Daisuke、Kobayashi Daiki、Ohto-Nakanishi Takayo、Akahoshi Noriyuki、Sekiba Atsushi、Toyoda Tsudoi、Ishijima Tomoko、Nakai Yuji、Shojima Nobuhiro、Kubota Naoto、Abe Keiko、Kadowaki Takashi、Ishii Satoshi、Shimizu Takao
- Journal Title
  
  JCI Insight
  
  Volume: 3 Issue: 24 Pages: 397293-397293
- DOI
  10.1172/jci.insight.97293
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07726, KAKENHI-PROJECT-18K19556, KAKENHI-PROJECT-18K19728, KAKENHI-PROJECT-16H05136, KAKENHI-PROJECT-17H01962
[Journal Article] The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells.2015
- Author(s)
  Igarashi H, Akahoshi N, Ohto-Nakanishi T, Yasuda D, Ishii S.
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 11410-11410
- DOI
  10.1038/srep11410
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460960, KAKENHI-PROJECT-26860169
[Journal Article] Trilogy of ACE2 : a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters2010
- Author(s)
  Kuba K, Imai Y, Ohto-N T, Penninger JM
- Journal Title
  
  Pharmacol. Ther
  
  Volume: 128 Pages: 119-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791744
[Journal Article] Trilogy of ACE2 : a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters.2010
- Author(s)
  Kuba K, Imai Y, Ohto-Nakanishi T, Penninger JM
- Journal Title
  
  Pharmacol.Ther.
  
  Volume: 128 Pages: 119-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791744
[Journal Article] Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis2010
- Author(s)
  Imai Y, Kuba K, Ohto-N T, Penninger JM
- Journal Title
  
  Circ. J.
  
  Volume: 74 Pages: 405-410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791744
[Journal Article] Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis.2010
- Author(s)
  Imai Y, Kuba K, Ohto-Nakanishi T, Penninger JM
- Journal Title
  
  Circ.J.
  
  Volume: 74 Pages: 405-410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791744
[Journal Article] 新型インフルエンザとacute respiratory distress syndrome (ARDS)2010
- Author(s)
  今井由美子, 大戸貴代, 久場敬司
- Journal Title
  
  日本集中治療医学会雑誌
  
  Volume: 17 Pages: 11-17
- NAID
  10026278043
- Data Source
  KAKENHI-PROJECT-22791744
[Presentation] リゾホスファチジン酸受容体LPA5を介したT細胞の分化運命決定機構2017
- Author(s)
  丸山貴司, 大戸貴代, 石井聡
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-16H05136
[Presentation] マウス喘息モデルにおけるリゾホスファチジン酸第五受容体 (LPA5) の病態生理機能2015
- Author(s)
  大戸貴代　竹田正秀　石井聡
- Organizer
  第57回日本脂質生化学会
- Place of Presentation
  一橋大学一橋講堂
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-26860169
[Presentation] リゾホスファチジン酸第五受容体 (LPA5) の喘息病態進展における重要性2015
- Author(s)
  大戸貴代　竹田正秀　石井聡
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会（BMB2015）
- Place of Presentation
  神戸国際展示場・神戸ポートピアホテル
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26860169

1. ISHII Satoshi (10300815)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. YASUDA Daisuke (70594951)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 丸山貴司 (10622524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 赤星軌征 (70534551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. NAKAI Yuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHTO Takayo 大戸 貴代

Research Projects

Research Products

Co-Researchers

Biological regulation by Galpha12/13-mediated lipid mediator function

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Lysophosphatidic acid receptor 4 as a potential drug target for the treatment of type 2 diabetesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Targeting bioactive lipid receptors for drug development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulatory mechanism of lipid mediator metabolism by phospholipaseA2s in influenza virus infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The Gα12/13-coupled receptor LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Trilogy of ACE2 : a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters2010

Author(s)

Journal Title

Data Source

[Journal Article] Trilogy of ACE2 : a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters.2010

Author(s)

Journal Title

Data Source

[Journal Article] Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis2010

Author(s)

Journal Title

Data Source

[Journal Article] Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis.2010

Author(s)

Journal Title

Data Source

[Journal Article] 新型インフルエンザとacute respiratory distress syndrome (ARDS)2010

Author(s)

Journal Title

NAID

Data Source

[Presentation] リゾホスファチジン酸受容体LPA5を介したT細胞の分化運命決定機構2017

Author(s)

Organizer

Data Source

[Presentation] マウス喘息モデルにおけるリゾホスファチジン酸第五受容体 (LPA5) の病態生理機能2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] リゾホスファチジン酸第五受容体 (LPA5) の喘息病態進展における重要性2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

OHTO Takayo 大戸貴代