Nakaya Takeo 仲矢丈雄

… Alternative Names

Researcher Number	80512277
Other IDs
Affiliation (Current)	2022: 自治医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2020: 自治医科大学, 医学部, 准教授 2015 – 2020: 自治医科大学, 医学部, 講師 2014: 杏林大学, 医学部, 助教 2012 – 2014: 東京医科大学, 医学部, 助教 2012: 東京大学, 大学院・医学系研究科, 特任助教
Review Section/Research Field	Principal Investigator Experimental pathology / Human pathology / Basic Section 49030:Experimental pathology-related Except Principal Investigator Cardiovascular medicine / Human pathology / Experimental pathology / Basic Section 53020:Cardiology-related / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 大腸癌 / KLF5 / 蛋白間相互作用 / 癌分子創薬 / 天然変性蛋白 / 蛋白間相互作用阻害薬 / KLF5阻害薬 / がん / エキソソーム / miRNA … More Except Principal Investigator KLF5 / 大腸癌 / 心不全 / 癌 / EBウイルス関連胃癌 / EBウイルス / 胃癌 / エピジェネティクス / LMP2A / SP細胞 / トランスジェニックマウス / マイクロRNA / 幹細胞 / エクソソーム / DNMT1 / STAT3 / 転写因子 / RRM2 / miR200 / 上皮間葉転換 / 胃癌細胞株 / KLF4 / colon cancer / stem cell / 大腸がん / がん幹細胞 / 癌幹細胞 / 蛋白間相互作用阻害薬 / 分子創薬 / 心血管リモデリング / KLF / In vivo蛋白複合体解析 / 心臓リモデリング / KLF5阻害薬 / 心‐脳‐腎臓器連関 / 蛋白複合体 / PDK4 / 立体構造解析 / in silico解析 / 平滑筋ミオシン / 家族性大動脈解離 / 血管老化機構 / Podoplanin / D2-40 / Prox1 / Allred score / 感度 / 特異度 / リンパ管 / 胸管 / 膵癌 / リンパ管侵襲 Less

膵癌リンパ管侵襲の病態解明とそれを抑制する新規治療法の開発
- Principal Investigator
  
  大城久
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Jichi Medical University
癌を選択的に抑制しかつ心機能を改善するKLF5阻害薬の開発とその分子作用機序解明Principal Investigator
- Principal Investigator
  
  仲矢丈雄
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Jichi Medical University
Molecular mechanism of familial aortic dissection by smooth muscle myosin mutation and elucidation of vascular aging mechanism
- Principal Investigator
  
  永井良三
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Jichi Medical University
Elucidation of the KLF protein complex in intestinal tissues and development of new drugs to suppress protein-protein interactions for the treatment of colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Nakaya Takeo
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Jichi Medical University
Protein complex analysis of transcriptional factor KLF, and development of a low molecular weight compound that inhibits KLF5 transcriptional activity.
- Principal Investigator
  
  Nagai Ryozo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Jichi Medical University
Improvement of the PDK4 inhibitors based on the tertiary structure analysis and application for the treatment of heart failure
- Principal Investigator
  
  Nagai Ryozo
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Jichi Medical University
Revealing the transcriptional network of the oncogenicity of intestinal stem cells and the development of new colorectal cancer therapyPrincipal Investigator
- Principal Investigator
  
  Nakaya Takeo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Jichi Medical University
  Kyorin University
Analysis of KLF5/4 complex in colon cancer development
- Principal Investigator
  
  KURODA Masahiko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Medical University
Development of new cancer therapy using the exosomes from patients.Principal Investigator
- Principal Investigator
  
  NAKAYA Takeo
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  Tokyo Medical University
EB virus-associated gastric carcinoma. Molecular mechanisms of DNA hypermethylation and strategy for gastric cancer therapy.
- Principal Investigator
  
  FUKAYAMA Masashi
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human pathology
- Research Institution
  The University of Tokyo

All 2018 2017 2016 2015 2014 2013 2012 2010 2009

All Journal Article Presentation Book

[Book] 化学2012
- Author(s)
  仲矢丈雄，黒田雅彦，大木忠明
- Total Pages
  5
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-24659166
[Journal Article] Giant solitary fibrous tumor of the pleura with high-grade sarcomatous overgrowth accompanied by lipid-rich, rhabdomyosarcomatous, and pleomorphic components: A case repor2017
- Author(s)
  Nakaya Takeo、Oshiro Hisashi、Takigami Ayako、Kanai Yoshihiko、Tetsuka Kenji、Hagiwara Koichi、Fujii Hirofumi、Endo Shunsuke、Tanaka Akira
- Journal Title
  
  Medicine (Baltimore). 2017 Dec;96(50):e8926.
  
  Volume: 96
- DOI
  10.1097/md.0000000000008926
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08718, KAKENHI-PROJECT-16K11158
[Journal Article] Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction2017
- Author(s)
  Michio Nakaya,Kenji Watari,Mitsuru Tajima,Takeo Nakaya,Shoichi Matsuda,Hiroki Ohara,Hiroaki Nishihara,Hiroshi Yamaguchi,Akiko Hashimoto,Mitsuho Nishida,Akiomi Nagasaka,Yuma Horii,Hiroki Ono,Gentaro Iribe,Ryuji Inoue,Makoto Tsuda,Kazuhide Inoue,Akira Tanaka,Masahiko Kuroda,Shigekazu Nagata,Hitoshi Kurose
- Journal Title
  
  J. Clin Invest.
  
  Volume: 127 Pages: 383-401
- DOI
  10.1172/jci83822
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01383, KAKENHI-PLANNED-25117013, KAKENHI-PROJECT-25253011, KAKENHI-PROJECT-16J03451, KAKENHI-PROJECT-26293088, KAKENHI-PROJECT-26461961, KAKENHI-PROJECT-15K15100, KAKENHI-PROJECT-16K08718, KAKENHI-PROJECT-15H05785, KAKENHI-PROJECT-17H01525, KAKENHI-PROJECT-15H04678
[Journal Article] A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation.2017
- Author(s)
  Fujiu K, Shibata M, Nakayama Y, Ogata F, Matsumoto S, Noshita K, Iwami S, Nakae S, Komuro I, Nagai R, Manabe I
- Journal Title
  
  Nat Med
  
  Volume: 印刷中 Pages: 611-622
- DOI
  10.1038/nm.4326
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01506, KAKENHI-PROJECT-16H05295, KAKENHI-PROJECT-16K15437, KAKENHI-PROJECT-16K09510, KAKENHI-PROJECT-15KT0107, KAKENHI-PROJECT-16K13777, KAKENHI-PROJECT-17K19644, KAKENHI-PROJECT-16H04845, KAKENHI-PROJECT-26287025, KAKENHI-PUBLICLY-17H05594, KAKENHI-ORGANIZER-26115001, KAKENHI-PROJECT-15H04824, KAKENHI-PROJECT-17H04171, KAKENHI-PROJECT-26461125, KAKENHI-PROJECT-16K19387, KAKENHI-PROJECT-17H01560
[Journal Article] Ectopic respiratory mucosa in the skin which showed the repetitive distribution of ciliated bronchogenic epithelia and squamous metaplasia2017
- Author(s)
  Nakano Naomi、Nakaya Takeo、Kamiya Koji、Komine Mayumi、Murata Satoru、Kawata Hirotoshi、Yokoyama Shigeo、Tanaka Akira、Ohtsuki Mamitaro
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 44 Pages: 1327-1328
- DOI
  10.1111/1346-8138.13697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08718
[Journal Article] Stimulation of cellular senescent processes, including secretory phenotypes and anti-oxidant responses, after androgen deprivation therapy in human prostate cancer2017
- Author(s)
  Kawata H, Kamiakito T, Nakaya T, Komatsubara M, Komatsu K, Morita T, Nagao Y, Tanaka A
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume: 165 Pages: 219-227
- DOI
  10.1016/j.jsbmb.2016.06.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860244, KAKENHI-PROJECT-16K08718
[Journal Article] Renal dysplasia characterized by prominent cartilaginous metaplasia lesions in VACTERL association2017
- Author(s)
  Nakaya Takeo、Hyuga Taiju、Tanaka Yukichi、Kawai Shina、Nakai Hideo、Niki Toshiro、Tanaka Akira
- Journal Title
  
  Medicine
  
  Volume: 96
- DOI
  10.1097/md.0000000000006499
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08718
[Journal Article] Excess lymphangiogenesis co-operatively induced by macrophages and CD4+ T cells drives the pathogenesis of lymphedema.2016
- Author(s)
  Ogata F
- Journal Title
  
  J Invest Dermatol
  
  Volume: 136 Pages: 706-714
- DOI
  10.1016/j.jid.2015.12.001
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01506, KAKENHI-PUBLICLY-15H01520, KAKENHI-PUBLICLY-26116722, KAKENHI-PROJECT-26293190, KAKENHI-PROJECT-15K20306, KAKENHI-PROJECT-25460473, KAKENHI-PROJECT-15H04824, KAKENHI-PROJECT-16K19387, KAKENHI-PROJECT-26670405
[Journal Article] Evaluation of the Human Papillomavirus mRNA Test for the detection of cervical lesions in Japan.2015
- Author(s)
  Nakayama Y, Yamada M, Kurata A, Kiseki H, Kuroda M.
- Journal Title
  
  Eur J Gynaec Oncol
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670197
[Journal Article] KLF5 regulates the integrity and oncogenicity of intestinal stem cells2014
- Author(s)
  Nakaya, T
- Journal Title
  
  Cancer Research
  
  Volume: 74 Pages: 2882-2891
- DOI
  10.1158/0008-5472.can-13-2574
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-22229006, KAKENHI-PROJECT-23390087, KAKENHI-PROJECT-24592039, KAKENHI-PROJECT-25670197, KAKENHI-PROJECT-26293088
[Journal Article] Enrichment of stem-like cell population comprises transformation ability of Epstein-Barr virus latent membrane protein 2A for non-transformed cells.2014
- Author(s)
  Nakaya T, Kikuchi Y, Kunita A, Ishikawa S, Matsusaka K, Hino R,Aburatani H
- Journal Title
  
  Virus Res.
  
  Volume: Vol.174 Pages: 108-115
- DOI
  10.1016/j.virusres.2013.03.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249022, KAKENHI-PLANNED-22134003, KAKENHI-PROJECT-23890036, KAKENHI-PROJECT-24221011, KAKENHI-PUBLICLY-25114702
[Journal Article] Multifocal Kaposiform Hemangioendothelioma in Multiple Visceral Organs: An Autopsy of 9-Day-Old Female Baby.2014
- Author(s)
  Takeo Nakaya, Kiyoko Morita, Atsushi Kurata,Tetsuo Ushiku, Takashi Igarashi, Masahiko Kuroda, Masashi Fukayama.
- Journal Title
  
  Human Pathology
  
  Volume: 45 Pages: 1773-1777
- DOI
  10.1016/j.humpath.2014.03.019
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592039, KAKENHI-PROJECT-25670197, KAKENHI-PROJECT-26293088, KAKENHI-PROJECT-26461961
[Journal Article] Young-age-onset pancreatoduodenal carcinoma in Shwachman-Diamond syndrome.2014
- Author(s)
  Nakaya T, Kurata A, Hashimoto H, Nishimata S, Kashiwagi Y, Fujita K, Kawashima H, Kuroda M.
- Journal Title
  
  Pathol Int.
  
  Volume: 64 Pages: 75-80
- DOI
  10.1111/pin.12133
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590431, KAKENHI-PROJECT-24592039, KAKENHI-PROJECT-25670197, KAKENHI-PROJECT-26293088
[Journal Article] Enrichment of stem-like cell population comprises transformation ability of Epstein-Barr virus latent membrane protein 2A for non-transformed cells.2013
- Author(s)
  Nakaya T
- Journal Title
  
  Virus Research
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249022
[Journal Article] Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma.2009
- Author(s)
  Hino R, Uozaki H, Murakami N, Ushiku T, Shinozaki A, Ishikawa S, Morikawa T, Nakaya T, Sakatani T, Takada K, Fukayama M.
- Journal Title
  
  Cancer Research. 69巻
  
  Pages: 2766-2774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249022
[Journal Article] Activation ofDNA methyltransferase 1 by EBV Latent Membrane Protein 2A Leads to Promoter Hypermethylation of PTEN Gene in Gastric Carcinoma2009
- Author(s)
  Hino R, Uozaki H, Murakami N, Ushiku T, Shinozaki A, Ishikawa S,Morikawa T, Nakaya T, Sakatani T,Takada K, Fukayama M
- Journal Title
  
  Cancer Research
  
  Volume: Vol.69 Pages: 2766-2774
- DOI
  10.1158/0008-5472.can-08-3070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249022
[Presentation] Small molecules mimicking KLF5 structure suppresses cancer cells in both in vivo and vitro without damaging normal cells.2018
- Author(s)
  Nakaya T, Tsuji K, Tanaka A, Nagai R.
- Organizer
  6th International Conference on Biology and Pathobiology of KLF/Sp Transcription Factors
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08718
[Presentation] Small molecular mimicries of KLF5 selectively suppress the survival and Wnt-KLF5 signaling of colorectal cancer cells.2016
- Author(s)
  仲矢丈雄、中野洋文、河西政次、吉森篤史、田中亨、小路弘行、永井良三
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜 (横浜、神奈川)
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15H04824
[Presentation] The protein interaction inhibitors of KLF5 suppress Wnt signalactivation selectively in colorectal cancer cells2016
- Author(s)
  Takeo Nakaya, Hirofumi Nakano, Masaji Kasai, Atsushi Yoshimori, Akira Tanaka, Hiroyuki Kouji, Ryozo Nagai
- Organizer
  FASEB Science Research Conference “KLF and Sp Transcription Factors in Disease and Regenerative Medicine”
- Place of Presentation
  Snowmass Base Village Conference Center (Snowmass Village, CO, USA)
- Year and Date
  2016-08-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04824
[Presentation] The protein interaction　inhibitors　of　KLF5　suppress　Wnt　signal　activation　selectively　in　colorectal　cancer cells2016
- Author(s)
  Takeo Nakaya, Hirofumi Nakano, Masaji Kasai, Atsushi Yoshimori, Akira Tanaka, Ryozo Nagai
- Organizer
  FASEB Science Research Conference ”KLF and Sp Transcription Factors in Disease and Regenerative Medicine"
- Place of Presentation
  Snowmass Base Village Conference Center (Snowmass, CO, USA)
- Year and Date
  2016-08-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08718
[Presentation] Small molecular mimicries of KLF5 selectively suppress the survival and Wnt-KLF5 signaling of colorectal cancer cells.2016
- Author(s)
  仲矢丈雄、中野洋文、河西政次、吉森篤史、田中亨、小路弘行、永井良三
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜 (横浜、神奈川)
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K08718
[Presentation] Epstein-Barrウイルス因子LMP2AのCancer Initiating Cells制御による発癌促進機構2010
- Author(s)
  仲矢丈雄, ら
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  京王プラザホテル(東京都新宿区)
- Year and Date
  2010-04-27
- Data Source
  KAKENHI-PROJECT-20249022
[Presentation] EBV-encoded protein LMP2A increases cancer stem enriched side population through activating Stat3, MEK/ERK pathways, and this promotes oncogenesis2009
- Author(s)
  仲矢丈雄, 他
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-20249022
[Presentation] EBウイルスの膜蛋白LMP2Aにより促進される発癌過程の解明2009
- Author(s)
  仲矢丈雄, 他
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜パシフィコ横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20249022

1. Nagai Ryozo (60207975)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. AIZAWA Kenichi (70436484)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. KURODA Masahiko (80251304)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. FUKAYAMA Masashi (70281293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. UOZAKI Hiroshi (10296246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. SAKATANI Takashi (50431903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. HINO Rumi (60451770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. USHIKU Tetsuo (60376415)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. MORIKAWA Teppei (80451772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. KIKUCHI Yoshinao (90512260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. SHINOZAKI Aya (60581824)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. KUNITA Akiko (50608768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. MATSUSAKA Keisuke (40610150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. YOKOYAMA Shigeyuki (00159229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 宮川拓也 (50596559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 田之倉優 (60136786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 今井靖 (20359631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 大城久 (60381513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 池田啓子 (10265241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 福嶋敬宜 (40384937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. NAKAYA Michio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. MATSUMOTO sahohime

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. NAKAYAMA yukiteru

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
24. 井上和秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 津田誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 長坂明臣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 黒瀬等

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 長田重一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 井上隆司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 眞鍋一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 藤生克仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 岩見真吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 小室一成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 石川俊平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 尾池雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 渡部徹郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 河田浩敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 倉田厚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakaya Takeo 仲矢 丈雄

NAKAYA Takeo 仲矢 丈雄

Research Projects

Research Products

Co-Researchers

膵癌リンパ管侵襲の病態解明とそれを抑制する新規治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

癌を選択的に抑制しかつ心機能を改善するKLF5阻害薬の開発とその分子作用機序解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of familial aortic dissection by smooth muscle myosin mutation and elucidation of vascular aging mechanism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the KLF protein complex in intestinal tissues and development of new drugs to suppress protein-protein interactions for the treatment of colorectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Protein complex analysis of transcriptional factor KLF, and development of a low molecular weight compound that inhibits KLF5 transcriptional activity.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Improvement of the PDK4 inhibitors based on the tertiary structure analysis and application for the treatment of heart failure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Revealing the transcriptional network of the oncogenicity of intestinal stem cells and the development of new colorectal cancer therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of KLF5/4 complex in colon cancer development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new cancer therapy using the exosomes from patients.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

EB virus-associated gastric carcinoma. Molecular mechanisms of DNA hypermethylation and strategy for gastric cancer therapy.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 化学2012

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Giant solitary fibrous tumor of the pleura with high-grade sarcomatous overgrowth accompanied by lipid-rich, rhabdomyosarcomatous, and pleomorphic components: A case repor2017

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[Journal Article] Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction2017

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Nakaya Takeo 仲矢丈雄

NAKAYA Takeo 仲矢丈雄