Tachibana Masashi 立花雅史

… Alternative Names

TACHIBANA Masashi 立花雅史

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Researcher Number	80513449
Other IDs
Affiliation (Current)	2025: 立命館大学, 生命科学部, 教授
Affiliation (based on the past Project Information) *help	2024 – 2025: 立命館大学, 生命科学部, 教授 2021 – 2023: 大阪大学, 大学院薬学研究科, 特任准教授(常勤) 2019 – 2020: 大阪大学, 薬学研究科, 特任准教授(常勤) 2017: 大阪大学, 薬学研究科, 特任准教授 2017: 大阪大学, 薬学研究科, 特任准教授(常勤) … More 2017: 大阪大学, 大学院・薬学研究科, 助教 2017: 大阪大学, 大学院薬学研究科, 特任准教授 2016: 大阪大学, 薬学研究科, 助教 2015: 大阪大学, 薬学研究科(研究院), 助教 2012 – 2013: 大阪大学, 薬学研究科(研究院), 助教 2011: The Institute of Physical and Chemical Research, 研究員 2009 – 2010: The Institute of Physical and Chemical Research, 免疫恒常性研究ユニット, 特別研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Biological pharmacy / Immunology Except Principal Investigator Applied pharmacology / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 90120:Biomaterials-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Biomedical engineering/Biomaterial science and engineering
Keywords	Principal Investigator 骨髄由来免疫抑制細胞 / 脂肪酸 / がん免疫 / パルミチン酸 / MDSC / 免疫抑制 / 代謝 / 免疫 / がん / 自然免疫 … More / 炎症性単球 / 炎症性樹状細胞 / Type I IFN / Th17 / 粘膜ワクチン / アデノウイルスベクター / T細胞 / 免疫寛容・抑制 / 肝臓 / 免疫寛容 / 免疫学 / T_<reg> / 自己免疫疾患 / Foxp3 / IPEX症候群 / 制御性T細胞 … More Except Principal Investigator 腫瘍溶解性ウイルス / 癌 / ウイルス / 免疫学 / がん治療 / Drug targeting / 人工受容体 / ケモカイン / エクソソーム / 腫瘍内浸潤 / がん / 自然免疫 / 細胞障害性T細胞 / レオウイルス / 抗腫瘍免疫 / 細胞外小胞 / がん微小環境 / 線維芽細胞 / 血管内皮細胞 / ダイレクトリプログラミング / 線維症 / プロセシング / microRNA / 腫瘍溶解性アデノウイルス / Dicer / 非コードRNA / アデノウイルス / バイオテクノロジー / 遺伝子 / 炎症性腸疾患 / 免疫異常 / 全身疾患誘発 / 薬理学 / 循環器・高血圧 / 生理活性 / 感染症 / NASH / 消化器疾患 / 口腔内細菌 / 口腔-腸相関 / ＮＡＳＨ / 糖尿病 / 脳卒中 / 循環器疾患 / 口腔細菌 / 局所感染 / 全身疾患 Less

Efficient Drug Targeting by oncolytic virus-meidated tumor-specific expression of artificial receptors
- Principal Investigator
  
  櫻井文教
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Kindai University
血管を経由する新発想での臓器の脱線維化技術の開発
- Principal Investigator
  
  岡田欣晃
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University
Regulation of myeloid-derived suppressor cells by palmitic acid metabolism for next-generation cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  立花雅史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Ritsumeikan University
  Osaka University
Elucidation of oncolytic virus-mediated intratumorl infiltration of immune cells and development of further promotion methods
- Principal Investigator
  
  櫻井文教
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Osaka University
Elucidation of the regulatory mechanisms myeloid-derived suppressor cells by lipid metabolism and its application to cancer therapyPrincipal Investigator
- Principal Investigator
  
  Tachibana Masashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Osaka University
Mechanisms of induction of mucosal immunity by adenovirus vector vaccinePrincipal Investigator
- Principal Investigator
  
  Tachibana Masashi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka University
Prediction and prevention of serious systemic diseases induced by local infection of bacteria
- Principal Investigator
  
  Wada Koichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Shimane University
The development of novel adenovirus vectors and application for treatment, prevention, and diagnosis of diseases
- Principal Investigator
  
  Mizuguchi Hiroyuki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Osaka University
Development of a novel oncolytic virus by regulating the processing of virus-derived non-coding RNA
- Principal Investigator
  
  SAKURAI FUMINORI
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Osaka University
Elucidation of the molecular mechanisms of immunological tolerance in liverPrincipal Investigator
- Principal Investigator
  
  TACHIBANA Masashi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka University
Foxp3変異マウスを用いた制御性T細胞機能解析Principal Investigator
- Principal Investigator
  
  立花雅史
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2010 2009 Other

All Journal Article Presentation

[Journal Article] Adoptively Transferred Myeloid-Derived Suppressor Cells Decrease Influenza A Virus Infection Mortality in a Mouse Model2024
- Author(s)
  Xie Zhiqi、 Atsushi Kawai、Nobumasa Watanabe、Okada Naoki、Yasuo Yoshioka、Tachibana Masashi
- Journal Title
  
  BPB Reports
  
  Volume: 7 Pages: 26-32
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24790
[Journal Article] Modified method for differentiation of myeloid-derived suppressor cells in vitro enhances immunosuppressive ability via glutathione metabolism2023
- Author(s)
  Zhou Haoyang、Xie Zhiqi、Morikawa Naosuke、Sakurai Fuminori、Mizuguchi Hiroyuki、Okuzaki Daisuke、Okada Naoki、Tachibana Masashi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 33 Pages: 101416-101416
- DOI
  10.1016/j.bbrep.2022.101416
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24790, KAKENHI-PROJECT-23K27671
[Journal Article] Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice2023
- Author(s)
  Xie Zhiqi、Zhou Haoyang、Obana Masanori、Fujio Yasushi、Okada Naoki、Tachibana Masashi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1243851-1243851
- DOI
  10.3389/fimmu.2023.1243851
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24790
[Journal Article] Pre-treatment of oncolytic reovirus improves tumor accumulation and intratumoral distribution of PEG-liposomes2023
- Author(s)
  Eguchi Maho、Hirata Seiya、Ishigami Ikuho、Shuwari Naomi、Ono Ryosuke、Tachibana Masashi、Tanuma Masato、Kasai Atsushi、Hashimoto Hitoshi、Ogawara Ken-ichi、Mizuguchi Hiroyuki、Sakurai Fuminori
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 354 Pages: 35-44
- DOI
  10.1016/j.jconrel.2022.12.050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19483, KAKENHI-PROJECT-20H00492, KAKENHI-PROJECT-21H03817
[Journal Article] Adenovirus vector-based vaccine for infectious diseases.2022
- Author(s)
  Sakurai F., Tachibana M., Mizuguchi H.
- Journal Title
  
  Drug Metab. Pharmacokinet.
  
  Volume: 42 Pages: 100432-100432
- DOI
  10.1016/j.dmpk.2021.100432
- NAID
  210000173033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00664, KAKENHI-PROJECT-21H03817
[Journal Article] Targeting GGT1 Eliminates the Tumor-Promoting Effect and Enhanced Immunosuppressive Function of Myeloid-Derived Suppressor Cells Caused by G-CSF2022
- Author(s)
  Xie Zhiqi、Kawasaki Takahiro、Zhou Haoyang、Okuzaki Daisuke、Okada Naoki、Tachibana Masashi
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 13 Pages: 873792-873792
- DOI
  10.3389/fphar.2022.873792
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24790
[Journal Article] Valproic acid attenuates CCR2-dependent tumor infiltration of monocytic myeloid-derived suppressor cells, limiting tumor progression2020
- Author(s)
  Xie Zhiqi、Ikegami Tamami、Ago Yukio、Okada Naoki、Tachibana Masashi
- Journal Title
  
  OncoImmunology
  
  Volume: 9 Issue: 1 Pages: 1734268-1734268
- DOI
  10.1080/2162402x.2020.1734268
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H04049
[Journal Article] パルミチン酸による骨髄由来免疫抑制細胞分化制御とがん治療への応用2020
- Author(s)
  立花雅史
- Journal Title
  
  Medical Science Digest
  
  Volume: 46 Pages: 40-41
- Data Source
  KAKENHI-PROJECT-19H04049
[Journal Article] パルミチン酸による骨髄由来免疫抑制細胞分化阻害と抗がん免疫応答の活性化2020
- Author(s)
  立花雅史
- Journal Title
  
  アグリバイオ
  
  Volume: 4 Pages: 71-3
- NAID
  40022320677
- Data Source
  KAKENHI-PROJECT-19H04049
[Journal Article] Type I interferons impede short-hairpin RNA-mediated RNA interference via inhibition of dicer-mediated processing to small interfering RNA.2017
- Author(s)
  Machitani M., Sakurai F., Wakabayashi K., Takayama K., Tachibana M., Mizuguchi H.
- Journal Title
  
  Mol. Ther. Nucleic Acids,
  
  Volume: 6 Pages: 173-182
- DOI
  10.1016/j.omtn.2016.12.007
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242048, KAKENHI-PROJECT-26293118, KAKENHI-PROJECT-17H04101
[Journal Article] Th17 Promotes Induction of antigen-specific gut-mucosal CTLs following adenovirus vector vaccination.2017
- Author(s)
  Hemmi M., Tachibana M.,, Fujimoto N., Shoji M., Sakurai F., Kobiyama K., Ishii K.J., Akira S., Mizuguchi H.
- Journal Title
  
  Front Immunol.
  
  Volume: 8 Pages: 1456-1456
- DOI
  10.3389/fimmu.2017.01456
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H00863, KAKENHI-PROJECT-15J05681, KAKENHI-PROJECT-16K18873
[Journal Article] Enhanced oncolytic activities of the telomerase-specific replication-competent adenovirus expressing short-hairpin RNA against Dicer2017
- Author(s)
  Machitani M., Sakurai F., Wakabayashi K., Tachibana M., Fujiwara T., Mizuguchi H.
- Journal Title
  
  Mol. Cancer Ther
  
  Volume: 16 Issue: 1 Pages: 251-259
- DOI
  10.1158/1535-7163.mct-16-0383
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26242048, KAKENHI-PROJECT-16J05920, KAKENHI-PROJECT-26293118
[Journal Article] MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2.2017
- Author(s)
  Machitani M, Sakurai F, Wakabayashi K, Nakatani K, Tachibana M, Mizuguchi H
- Journal Title
  
  Journalof Virology
  
  Volume: 印刷中 Issue: 12
- DOI
  10.1128/jvi.00159-17
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16J05920, KAKENHI-PROJECT-26293118, KAKENHI-PROJECT-17H00863
[Journal Article] Inhibition of CRISPR/Cas9-Mediated Genome Engineering by a Type I Interferon-Induced Reduction in Guide RNA Expression2017
- Author(s)
  Machitani M., Sakurai F., Wakabayashi K., Nakatani K., Takayama K., Tachibana M., Mizuguchi H.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 3 Pages: 272-277
- DOI
  10.1248/bpb.b16-00700
- NAID
  130005398474
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242048, KAKENHI-PROJECT-16J05920, KAKENHI-PROJECT-26293118, KAKENHI-PROJECT-17H00863
[Journal Article] TANK-binding kinase 1-dependent or -independent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector.2016
- Author(s)
  Tsuzuki S, Tachibana M, Hemmi M, Yamaguchi T, Shoji M, Sakurai F, Kobiyama K, Kawabata K, Ishii KJ, Akira S, Mizuguchi H.
- Journal Title
  
  Int Immunol.
  
  Volume: 28 Issue: 3 Pages: 105-115
- DOI
  10.1093/intimm/dxv058
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242048, KAKENHI-PROJECT-15J05681
[Journal Article] Dicer functions as an antiviral system against human adenoviruses via cleavage of adenovirus-encoded noncoding RNA.2016
- Author(s)
  Machitani M, Sakurai F, Wakabayashi K, Tomita K, Tachibana M, Mizuguchi H
- Journal Title
  
  Scientific Reports
  
  Volume: - Issue: 1 Pages: 27598-27598
- DOI
  10.1038/srep27598
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16J05920, KAKENHI-PROJECT-26293118
[Journal Article] Quantitative Analysis of Virus-associated RNAI Expression following Transduction with a Replication-incompetent Adenovirus Vector In Vitro and In Vivo.2015
- Author(s)
  Wakabayashi K., Machitani M., Shimizu K., Tachibana M., Sakurai F., Mizuguchi H.
- Journal Title
  
  J. Mol. Genet. Med.
  
  Volume: 9 Issue: 02 Pages: 169-169
- DOI
  10.4172/1747-0862.1000169
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242048, KAKENHI-PROJECT-15H06363, KAKENHI-PROJECT-26293118
[Journal Article] The early activation of CD8+ T cells is dependent on type I IFN signaling following intramuscular vaccination of adenovirus vector.2014
- Author(s)
  Hemmi M, Tachibana M, Tsuzuki S, Shoji M, Sakurai F, Kawabata K, Kobiyama K, Ishii KJ, Akira S, Mizuguchi H.
- Journal Title
  
  BioMed Res. International
  
  Volume: - Pages: 158128-158128
- DOI
  10.1155/2014/158128
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242048
[Journal Article] Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome2014
- Author(s)
  Sakurai F, Shimizu K, Tomita K, Nagamoto Y, Nakamura S, Katayama K, Tachibana M, Kawabata K, Mizuguchi H.
- Journal Title
  
  Mol Ther Methods Clin Dev
  
  Volume: 1 Pages: 14035-14035
- DOI
  10.1038/mtm.2014.35
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300155, KAKENHI-PROJECT-26242048
[Presentation] 肺炎における免疫毒性発現因子としての骨髄由来免疫抑制細胞2023
- Author(s)
  謝智奇、周浩洋、尾花理徳、藤尾慈、岡田直貴、立花雅史
- Organizer
  第30回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-23K24790
[Presentation] Lung inflammation induced by poly(I:C) intranasal administration in mice with renal injury and older mice is exacerbated by myeloid-derived suppressor cells2023
- Author(s)
  Zhiqi Xie, Haoyang Zhou, Masanori Obana, Yasushi Fujio, Naoki Okada, Masashi Tachibana
- Organizer
  JSICR/MMCB 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24790
[Presentation] 肝細胞癌における骨髄由来免疫抑制細胞の浸潤に対するHDAC阻害剤のDe-Targeting効果2023
- Author(s)
  立花雅史、謝智奇、奥崎大介、岡田直貴
- Organizer
  第39回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24790
[Presentation] パルミチン酸による骨髄細胞の免疫抑制機能獲得阻害機構の解明2023
- Author(s)
  立花雅史
- Organizer
  第5回がんと代謝研究会・若手の会
- Data Source
  KAKENHI-PROJECT-23K24790
[Presentation] HDAC inhibitors inhibit invasion of monocytic myeloid-derived suppressor cells into hepatocellular carcinoma2022
- Author(s)
  Masashi Tachibana, Daisuke Okuzaki, Naoki Okada
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24790
[Presentation] G-CSFはGGT1を介して骨髄由来免疫抑制細胞の免疫抑制能を増強させる2022
- Author(s)
  謝智奇、周浩洋、奥崎大介、岡田直貴、立花雅史
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] Reovirus-infected cell-derived small extracellular vesicles efficiently suppress the subcutaneous tumor growth following intravenous administration in mice2022
- Author(s)
  Fuminori Sakurai, Naomi Shuwari, Chieko Inoue, Masashi Tachibana, Kentaro Jingushi, Kazutake Tsujikawa, Hiroyuki Mizuguchi
- Organizer
  14th International Virotherapy Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03817
[Presentation] G-CSFによるGGT1依存的な骨髄由来免疫抑制細胞の免疫抑制能増強2022
- Author(s)
  立花雅史、謝智奇、周浩洋、奥崎大介、岡田直貴
- Organizer
  第8回がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-23K24790
[Presentation] HDACによる骨髄由来免疫抑制細胞の制御2022
- Author(s)
  立花雅史
- Organizer
  第4回がんと代謝研究会・若手の会
- Data Source
  KAKENHI-PROJECT-23K24790
[Presentation] Involvement of IPS-1-dependent signaling in reovirus-induced tumor infiltration of CD8+ cells2022
- Author(s)
  Maho Eguchi, Masashi Tachibana, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi, Fuminori Sakurai
- Organizer
  14th International Virotherapy Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03817
[Presentation] GGT1-dependent or -independent regulation of myeloid-derived suppressor cells by G-CSF2022
- Author(s)
  Zhiqi Xie, Haoyang Zhou, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana
- Organizer
  JSICR/MMCB 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24790
[Presentation] Epigenetic modulation with valproic acid impedes invasion of monocytic myeloid-derived suppressor cells into tumors2021
- Author(s)
  Zhiqi Xie, Yukio Ago, Naoki Okada, Masashi Tachibana
- Organizer
  MMCB2020+1
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] 骨髄由来免疫抑制細胞の腫瘍への移行に対するバルプロ酸のDe-Targeting効果2021
- Author(s)
  謝智奇, 吾郷由希夫, 岡田直貴, 立花雅史
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] 骨髄由来免疫抑制細胞を介した免疫毒性発現に関する研究2021
- Author(s)
  立花雅史
- Organizer
  第27回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] Optimization of the method for in vitro MDSC differentiation2021
- Author(s)
  Haoyang Zhou, Zhiqi Xie, Naoki Okada, Masashi Tachibana
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] ヒストン脱アセチル化酵素1,2,3が骨髄由来免疫抑制細胞の機能を減弱させる2021
- Author(s)
  謝　智奇、岡田　直貴、立花　雅史
- Organizer
  第71回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] Ly-6G+細胞除去によるin vitro MDSC分化誘導効率の向上2021
- Author(s)
  周浩洋、岡田直貴、立花雅史
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] G-CSF enhances immunosuppressive activity of MDSCs by GGT12021
- Author(s)
  Zhiqi Xie, Haoyang Zhou, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] IL-10/IL-17A欠損腸炎モデルにおける骨髄由来免疫抑制細胞と一酸化窒素の機能解析2020
- Author(s)
  立花雅史，渡邊伸昌，幸田裕造，大屋有佳子，神沼修，形山和史，范子非，櫻井文教，川端健二，廣井隆親，水口裕之
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] バルプロ酸によるエピジェネティックな制御は単球様骨髄由来免疫抑制細胞の腫瘍への移行を妨げる2020
- Author(s)
  謝智奇、岡田直貴、立花雅史
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] バルプロ酸による腫瘍内単球様骨髄由来免疫抑制細胞の減少と抗PD-1抗体療法の有効性向上2020
- Author(s)
  謝智奇、池上珠未、吾郷由希夫、岡田直貴、立花雅史
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] パルミチン酸によるToll-like receptor 2を介した骨髄由来免疫抑制細胞の分化阻害2020
- Author(s)
  周浩洋、謝智奇、川崎太寛、岡田直貴、立花雅史
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] バルプロ酸が骨髄由来免疫抑制細胞に作用し抗PD-1抗体の効果を向上させる2020
- Author(s)
  謝智奇、池上珠未、吾郷由希夫、岡田直貴、立花雅史
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] うつ病における骨髄由来免疫抑制細胞の寄与に関する解析2020
- Author(s)
  池上珠未, 吾郷由希夫, 塚田信司, 谷林耕平, 岡田直貴, 立花雅史
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] G-CSF刺激を与えた骨髄由来免疫抑制細胞における免疫抑制能増強メカニズムの解析2020
- Author(s)
  川崎太寛、奥崎大介、岡田直貴、立花雅史
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] 担がん病態におけるバルプロ酸の免疫機能修飾についての検討2019
- Author(s)
  謝智奇、池上珠未、吾郷由希夫、岡田直貴、立花雅史
- Organizer
  第26回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] 骨髄系細胞によるがん随伴うつ発症に関する解析2019
- Author(s)
  池上珠未, 吾郷由希夫, 塚田信司, 谷林耕平, 岡田直貴, 立花雅史
- Organizer
  第3回がんと代謝研究会・若手の会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] Inhibition of myeloid-derived suppressor cell differentiation by palmitic acid2019
- Author(s)
  Masashi Tachibana, Koji Kobiyama, Ken J. Ishii, Shizuo Akira, Fuminori Sakurai
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] Contribution of myeloid-derived suppressor cells to onset of cancer-induced depression2019
- Author(s)
  Tamami Ikegami, Naoki Okada, Masashi Tachibana
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] Valproic acid attenuates myeloid-derived suppressor cells and enhances anti-PD-1 therapy response2019
- Author(s)
  Zhiqi Xie, Tamami Ikegami, Naoki Okada, and Masashi Tachibana
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H04049
[Presentation] Th17 promotes the induction of antigen-specific gut-mucosal cytotoxic T lymphocytes following intramuscular vaccination of an adenovirus vector2018
- Author(s)
  Masashi Tachibana, Masahisa Hemmi, Natsuki Fujimoto, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  第１１回次世代アジュバント研究会
- Data Source
  KAKENHI-PROJECT-16K18873
[Presentation] 粘膜免疫誘導型ワクチンとしてのアデノウイルスベクター2017
- Author(s)
  立花雅史、辺見昌久、藤本夏希、庄司正樹、櫻井文教、小檜山康司、石井健、審良静男、水口裕之
- Organizer
  第33回日本DDS学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K18873
[Presentation] Th17 promotes the induction of antigen-specific gut-mucosal CTLs following intramuscular vaccination of an adenovirus vector2017
- Author(s)
  Masahisa Hemmi, Masashi Tachibana, Natsuki Fujimoto, Masaki Shoji, Fuminori Sakurai, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K18873
[Presentation] アデノウイルス由来マイクロRNAによるウイルス増殖の促進2017
- Author(s)
  若林圭作、町谷充洋、立花雅史、櫻井文教、水口裕之
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Adenovirus vector-induced hepatotoxicity during the early phase of adenoviral treatment is attributed to inflammatory cytokine-induced leaky expression of adenovirus genes2017
- Author(s)
  Kahori Shimizu, Fuminori Sakurai, Shunsuke Iizuka, Masashi Tachibana, Toru Nishinaka, Tomoyuki Terada, Hiroyuki Mizuguchi
- Organizer
  20th annual meeting of American society of Gene and Cell Therapy
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] アデノウイルスベクターワクチンによる粘膜免疫誘導メカニズム解明－Ｉ型インターフェロンシグナル依存的に制御される炎症性単球の役割－2017
- Author(s)
  藤本夏希、立花雅史、辺見昌久、庄司正樹、櫻井文教、審良静男、水口裕之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター、東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K18873
[Presentation] 宿主miR-27によるSNAP25及びTXN2の発現抑制はアデノウイルス感染を阻害する2017
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Adenovirus vector-induced hepatotoxicity during the early phase after systemic administration is attributed to inflammatory cytokine-induced leaky expression of adenovirus genes2017
- Author(s)
  Kahori Shimizu, Fuminori Sakurai, Shunsuke Iizuka, Masashi Tachibana, Toru Nishinaka, Tomoyuki Terada, Hiroyuki Mizuguchi
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] 肝臓特異的なマイクロRNAを利用して肝障害性を低減させた新規アデノウイルスベクターによる血友病遺伝子治療に関する検討2017
- Author(s)
  飯塚俊輔、櫻井文教、立花雅史、大橋一夫、水口裕之
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] miR-27 inhibits adenovirus infection via the suppression of SNAP25 and TXN2 expressions2017
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] アデノウイルスがコードするマイクロRNAのウイルス増殖促進機構の解明2017
- Author(s)
  若林圭作、町谷充洋、櫻井文教、立花雅史、水口裕之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] アデノウイルスがコードするマイクロ RNA のウイルス増殖促進機構の解明2017
- Author(s)
  若林圭作、町谷充洋、立花雅史、櫻井文教、水口裕之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター、東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルスベクターワクチンによる粘膜免疫誘導メカニズム解明2017
- Author(s)
  藤本夏希、立花雅史、辺見昌久、庄司正樹、櫻井文教、審良静男、水口裕之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター、東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] 高効率かつ長期的な遺伝子発現が可能な新規Adベクターによる血友病B遺伝子治療効果の検討2017
- Author(s)
  飯塚俊輔、櫻井文教、立花雅史、大橋一夫、水口裕之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター、東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Type I IFN signaling induces Th17 cells capable of promoting gut-mucosal CTLs following intramuscular vaccination of an adenovirus vector2017
- Author(s)
  Masahisa Hemmi, Masashi Tachibana, Natsuki Fujimoto, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  5th Annual Meeting of the International Cytokine and Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18873
[Presentation] Promotion of adenovirus infection by a microRNA derived from adenovirus Virus-Associated RNA II.2017
- Author(s)
  Keisaku Wakabayashi, Mitsuhiro Machitani, Masashi Tachibana, Fuminori Sakurai, Hiroyuki Mizuguchi
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] アデノウイルス外殻蛋白質に対する抗体がアデノウイルスベクターによる遺伝子導入に与える影響の解析2016
- Author(s)
  冨田恭子、櫻井文教、町谷充洋、立花雅史、水口裕之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Type I interferons impede short-hairpin RNA-mediated RNA interference via inhibition of dicer-mediated processing to small interfering RNA2016
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第22回日本遺伝子細胞治療学会総会
- Place of Presentation
  虎ノ門ヒルズフォーラム(東京)
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] I型IFNによるCRISPR/Cas9システムを用いたゲノム編集効率の低下2016
- Author(s)
  町谷充洋、櫻井文教、若林圭作、中谷光佑、高山和雄、立花雅史、水口裕之
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] 全身系投与型アデノウイルスベクターワクチンによる粘膜免疫誘導に重要なⅠ型IFNシグナルの解析2016
- Author(s)
  辺見昌久、立花雅史、藤本夏希、庄司正樹、櫻井文教、小檜山康司、石井健、審良静男、水口裕之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] I型IFNによるCRISPR/Cas9システムを用いたゲノム編集効率の低下2016
- Author(s)
  町谷充洋、櫻井文教、若林圭作、中谷光佑、高山和雄、立花雅史、水口裕之
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  東京
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Type I IFN signaling regulates the antigen-specific mucosal immunity following systemic administration of an adenovirus vector vaccine2016
- Author(s)
  Masahisa Hemmi, Masashi Tachibana, Fujimoto Natsuki, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  European Society of Gene and Cell Therapy (ESGCT) 2016 Annual Congress
- Place of Presentation
  フィレンツェ（イタリア）
- Year and Date
  2016-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18873
[Presentation] ウイルス遺伝子の発現を低減させた改良型アデノウイルスベクターの新生仔マウスにおける遺伝子導入特性の解明と血友病遺伝子治療に関する検討2016
- Author(s)
  飯塚俊輔、櫻井文教、立花雅史、大橋一夫、水口裕之
- Organizer
  第32回日本DDS学会学術集会
- Place of Presentation
  静岡コンベンションアーツセンター (静岡県静岡市)
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Small RNA derived from Adenovirus Virus-Associated RNA II, mivaRNA II, promotes Ad replication via post-transcriptional gene silencing2016
- Author(s)
  Keisaku Wakabayashi, Mitsuhiro Machitani, Masashi Tachibana、Fuminori Sakurai、Hiroyuki Mizuguchi
- Organizer
  The 24th Annual Congress of European Society of Gene and Cell Therapy
- Place of Presentation
  フィレンツェ、イタリア
- Year and Date
  2016-10-18
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Type I IFN signaling plays an important role in recruiting inflammatory monocytes following adenovirus vector vaccination2016
- Author(s)
  Natsuki Fujimoto, Masashi Tachibana, Masahisa Hemmi, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K18873
[Presentation] CRISPR/Cas9システム搭載Adベクターの開発と機能評価2016
- Author(s)
  中谷光佑、町谷充洋、高山和雄、立花雅史、櫻井文教、水口裕之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] miR-27によるCyclin G1の発現抑制がアデノウイルス感染に与える影響2016
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Small RNA derived from Adenovirus Virus-Associated RNA II, mivaRNA II, promotes Ad replication via post-transcriptional gene silencing2016
- Author(s)
  Keisaku Wakabayashi, Mitsuhiro Machitani, Masashi Tachibana, Fuminori Sakurai, Hiroyuki Mizuguchi
- Organizer
  European Society of Gene and Cell Therapy (ESGCT) 2016 Annual Congress
- Place of Presentation
  フィレンツェ（イタリア）
- Year and Date
  2016-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Type I IFN signaling induces inflammatory DCs following intramuscular administration of an adenovirus vector vaccine2016
- Author(s)
  Masahisa Hemmi, Masashi Tachibana, Fujimoto Natsuki, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K18873
[Presentation] Effects of antibodies against adenoviral capsid proteins on adenovirus vector-mediated in vivo transduction2016
- Author(s)
  Kyoko Tomita, Fuminori Sakurai, Mitsuhiro Machitani, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  European Society of Gene and Cell Therapy (ESGCT) 2016 Annual Congress
- Place of Presentation
  フィレンツェ（イタリア）
- Year and Date
  2016-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルス外殻蛋白質に対する抗体がアデノウイルスベクターによる遺伝子導入に与える影響の解析2016
- Author(s)
  冨田恭子、櫻井文教、町谷充洋、立花雅史、水口裕之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Neonatal gene therapy for hemophilia B by a novel adenovirus vector showing reduction in the leaky expression of viral genes.2016
- Author(s)
  Shunsuke Iizuka, Fuminori Sakurai, Masashi Tachibana, Kazuo Ohashi, Hiroyuki Mizuguchi
- Organizer
  第22回日本遺伝子細胞治療学会
- Place of Presentation
  虎ノ門ヒルズ (東京都)
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Type I IFN signaling regulates the antigen-specific mucosal immunity following systemic administration of an adenovirus vector vaccine2016
- Author(s)
  Masahisa Hemmi, Masashi Tachibana, Fujimoto Natsuki, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  European Society of Gene and Cell Therapy (ESGCT) 2016 Annual Congress
- Place of Presentation
  フィレンツェ（イタリア）
- Year and Date
  2016-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] miR-27によるCyclin G1の発現抑制がアデノウイルス感染に与える影響2016
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Type I IFN signaling induces inflammatory DCs following intramuscular administration of an adenovirus vector vaccine2016
- Author(s)
  Masahisa Hemmi, Masashi Tachibana, Fujimoto Natsuki, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Type I interferons impede short-hairpin RNA-mediated RNA interference via inhibition of dicer-mediated processing to small interfering RNA2016
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  The 22nd annual meeting of JSGCT
- Place of Presentation
  東京
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Type I IFN signaling plays an important role in recruiting inflammatory monocytes following adenovirus vector vaccination2016
- Author(s)
  Natsuki Fujimoto, Masashi Tachibana, Masahisa Hemmi, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Type I IFN signaling induces inflammatory DCs following intramuscular administration of an adenovirus vector vaccine2016
- Author(s)
  Masahisa Hemmi, Masashi Tachibana, Fujimoto Natsuki, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  第24回マクロファージ分子細胞生物学国際シンポジウム
- Place of Presentation
  ソラシティカンファレンスセンター（東京都千代田区）
- Year and Date
  2016-06-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18873
[Presentation] Type I IFN signaling induces inflammatory DCs following intramuscular administration of an adenovirus vector vaccine2016
- Author(s)
  Masahisa Hemmi, Masashi Tachibana, Fujimoto Natsuki, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  第24回マクロファージ分子細胞生物学国際シンポジウム
- Place of Presentation
  ソラシティカンファレンスセンター（東京都千代田区）
- Year and Date
  2016-06-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] CRISPR/Cas9システム搭載アデノウイルスベクターの開発と機能評価2016
- Author(s)
  中谷光佑、町谷充洋、高山和雄、立花雅史、櫻井文教、水口裕之
- Organizer
  第66 回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学（大阪府高槻市）
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルスが発現するマイクロRNAの機能解析2016
- Author(s)
  若林圭作、町谷充洋、櫻井文教、立花雅史、水口裕之
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  東京
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] 筋肉内投与されたアデノウイルスベクターワクチンによる腸管粘膜免疫誘導に重要なⅠ型IFNシグナルの解析2015
- Author(s)
  辺見昌久、立花雅史、続木沙也加、庄司正樹、櫻井文教、川端健二、小檜山康司、石井健、審良静男、水口裕之
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Type I IFN signaling regulates the antigen-specific mucosal immunity following systemic vaccination of an adenovirus vector2015
- Author(s)
  Masahisa Hemmi, Masashi Tachibana, Natsuki Fujimoto, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Kenji Kawabata, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] NASH/NAFLD関連マイクロRNA miR-27bの脂質蓄積促進能を担う標的遺伝子の解析2015
- Author(s)
  鈴木瑠々香, 酒井英子, 立花雅史, 櫻井文教, 結束貴臣, 中島淳, 和田孝一郎, 水口裕之
- Organizer
  ＢＭＢ2015
- Place of Presentation
  神戸市（神戸ポートアイランド国際会議場）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04757
[Presentation] Quantitative analysis of virus-associated RNAI expression following transduction with a replication-incompetent adenovirus vector in vitro and in vivo.2015
- Author(s)
  Keisaku Wakabayashi, Mitsuhiro Machitani, Kahori Shimizu, Masashi Tachibana, Fuminori Sakurai, Hiroyuki Mizuguchi
- Organizer
  第21回日本遺伝子治療学会総会
- Place of Presentation
  大阪国際会議場 (大阪府大阪市)
- Year and Date
  2015-07-25
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Inhibitory effects of adenovirus neutralizing antibodies against different adenoviral capsid proteins on transduction with an adenovirus vector2015
- Author(s)
  Kyoko Tomita, Fuminori Sakurai, Mitsuhiro Machitani, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第21回日本遺伝子治療学会総会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルス由来小分子RNAの機能特性に立脚した遺伝子治療用組み換えウイルスの開発2015
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、藤原俊義、水口裕之
- Organizer
  第65回日本薬学会近畿支部総会
- Place of Presentation
  大阪大谷大学 (大阪府富田林市)
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Type I IFN signaling induced by systemically administrated adenovirus vector promotes the antigen-specific mucosal immunity2015
- Author(s)
  Masahisa Hemmi, Masashi Tachibana, Sayaka Tsuzuki, Masaki Shoji, Fuminori Sakurai, Kenji Kawabata, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  第21回日本遺伝子治療学会総会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Expression profile of virus-associated RNAI following transduction with a replication-incompetent adenovirus vector in vitro and in vivo.2015
- Author(s)
  Keisaku Wakabayashi, Mitsuhiro Machitani, Kahori Shimizu, Masashi Tachibana, Fuminori Sakurai, Hiroyuki Mizuguchi
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場 (福岡県福岡市)
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] TBK1 and type I IFN signaling play different roles in the induction of antigen-specific adaptive immunity following adenovirus vector vaccination2015
- Author(s)
  Natsuki Fujimoto, Masashi Tachibana, Masahisa Hemmi, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Kenji Kawabata, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] NF-κB mediates leaky expression of adenovirus genes in a replication-incompetent adenovirus vector2015
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第21回日本遺伝子治療学会総会
- Place of Presentation
  大阪国際会議場 (大阪府大阪市)
- Year and Date
  2015-07-25
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルスベクターワクチンによる獲得免疫誘導機構の解明2015
- Author(s)
  藤本夏希、立花雅史、辺見昌久、庄司正樹、櫻井文教、小檜山康司、川端健二、石井健、審良静男、水口裕之
- Organizer
  第65回日本薬学会近畿支部総会
- Place of Presentation
  大阪大谷大学（大阪府富田林市）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Inhibition of NF-κB leads to suppression of Ad vector-mediated hepatotoxicities via reduction in the leaky expression of Ad genes2015
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場 (福岡県福岡市)
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルス由来小分子RNAの機能特性に立脚した新規腫瘍溶解性ウイルスの開発2015
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、藤原俊義、水口裕之
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪府富田林市
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Inhibition of in vivo transduction with adenovirus vectors via antibodies against adenovirus capsid proteins2015
- Author(s)
  Kyoko Tomita, Fuminori Sakurai, Mitsuhiro Machitani, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Reduction in the leaky expression of Ad genes from a replication-incompetent adenovirus vector by inhibition of NF-κB2015
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第74回日本癌学会学術集会
- Place of Presentation
  名古屋国際会議場 (愛知県名古屋市)
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルス感染に対する防御機構としてのDicerの役割2015
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
- Organizer
  第38回日本分子生物学会年会第88回日本生化学大会合同大会
- Place of Presentation
  神戸ポートアイランド (兵庫県神戸市)
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルス感染に対する防御機構としてのDicerの役割2015
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
- Organizer
  第38回　日本分子生物学会年会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] アデノウイルスベクターの新生児マウスにおける遺伝子発現特性の解析2014
- Author(s)
  飯塚俊輔、櫻井文教、清水かほり、立花雅史、水口裕之
- Organizer
  第64回日本薬学会近畿支部総会
- Place of Presentation
  京都薬科大学（京都府京都市）
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] レオウイルスによる低酸素誘導因子HIF-1α発現量低下における核酸認識受容体の2014
- Author(s)
  宝谷拓磨、立花雅史、水口裕之、櫻井文教
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都薬科大学
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Dicerのノックダウンによるアデノウイルスベクター用新規パッケージング細胞の開発2014
- Author(s)
  若林圭作、町谷充洋、櫻井文教、立花雅史、水口裕之
- Organizer
  第64回日本薬学会近畿支部総会
- Place of Presentation
  京都薬科大学（京都府京都市）
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Dicerのノックダウンによるアデノウイルスベクター用新規パッケージング細胞の開発2014
- Author(s)
  若林圭作、町谷充洋、櫻井文教、立花雅史、水口裕之
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都薬科大学
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Impact of IPEX mutations on regulatory T cell development, homeostasis and function2010
- Author(s)
  TACHIBANA Masashi
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  神戸
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21790484
[Presentation] Impact of IPEX mutations on regulatory T cell development and function IPEX変異が制御性T細胞分化・機能に与える影響2009
- Author(s)
  立花雅史、堀昌平
- Organizer
  第39回日本免疫学会学術総会
- Place of Presentation
  大阪市
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-21790484
[Presentation] microRNA依存的にウイルス遺伝子の発現を抑制可能な新規アデノウイルスベクターの開発
- Author(s)
  櫻井文教、清水かほり、冨田恭子、長基康人、立花雅史、水口裕之
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  慶應義塾大学薬学部　芝共立キャンパス（東京都港区）
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] RNA干渉に関わる因子であるDicerはアデノウイルスに対する防御機構として機能する
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] 新生仔マウスにおけるアデノウイルスベクターによる遺伝子導入特性の解析
- Author(s)
  飯塚俊輔、櫻井文教、清水かほり、立花雅史、大橋一夫、水口裕之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学・兵庫医療大学（兵庫県神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Dicerはアデノウイルス由来小分子RNA（VA-RNA）の切断を介してアデノウイルスの感染を抑制する
- Author(s)
  櫻井文教、町谷充洋、若林圭作、立花雅史、水口裕之
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Dicerノックダウン細胞を用いたアデノウイルスベクター作製効率の改善に関する検討
- Author(s)
  若林圭作、町谷充洋、櫻井文教、立花雅史、水口裕之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学・兵庫医療大学（兵庫県神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] マイクロRNAプロセシング因子の制御による腫瘍溶解性アデノウイルスの機能向上
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、藤原俊義、水口裕之
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  慶応大学薬学部
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Dicerはアデノウイルス由来小分子RNA（VA-RNA）の切断を介してアデノウイルスの感染を抑制する
- Author(s)
  櫻井文教、町谷充洋、若林圭作、立花雅史、水口裕之
- Organizer
  第62回ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Evaluation of involvement of microRNA processing factors in adenovirus replication
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  American Society of Gene & Cell Therapy, 17th Annual Meeting 2014
- Place of Presentation
  ワシントンDC（USA）
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] NF-κBがアデノウイルスの増殖に及ぼす影響に関する検討
- Author(s)
  町谷充洋、櫻井文教、清水かほり、立花雅史、水口裕之
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Type-I IFN signaling induced by systemically administrated adenovirus vector promotes the antigen-specific mucosal immunity
- Author(s)
  Masahisa Henmi, Masashi Tachibana, Sayaka Tsuzuki, Masaki Shoji, Fuminori Sakurai, Koji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  American Society of Gene & Cell Therapy, 17th Annual Meeting 2014
- Place of Presentation
  ワシントンDC（USA）
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] RNA干渉に関わる因子であるDicerはアデノウイルスに対する防御機構として機能する
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学・兵庫医療大学（兵庫県神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Cathepsin activity levels in tumor cells are a crucial determinant for reovirus oncolysis
- Author(s)
  Fuminori Sakurai, Yuichi Terasawa, Masahi Tachibana, Hiroyuki Mizuguchi
- Organizer
  American Society of Gene & Cell Therapy, 17th Annual Meeting
- Place of Presentation
  ワシントンDC
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Development of a novel oncolytic adenovirus expressing a short-hairpin RNA against a microRNA processing factor
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Masashi Tachibana, Toshiyoshi Fujiwara, Hiroyuki Mizuguchi
- Organizer
  第73回日本癌学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Dicerノックダウン細胞を用いたアデノウイルスベクター作製効率の改善に関する検討
- Author(s)
  若林圭作、町谷充洋、櫻井文教、立花雅史、水口裕之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] MICRORNA PROCESSING FACTORS REGULATE ADENOVIRUS REPLICATION
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第20回日本遺伝子治療学会総会
- Place of Presentation
  慈恵医科大学
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Evaluation of involvement of microRNA processing factors in adenovirus replication
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  American Society of Gene & Cell Therapy, 17th Annual Meeting
- Place of Presentation
  ワシントンDC
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] レオウイルスによる低酸素誘導因子HIF-1α発現量低下に関する分子機構の解明
- Author(s)
  宝谷拓磨、立花雅史、水口裕之、櫻井文教
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] miR-27はCyclin G1の発現抑制を介してアデノウイルスの増殖を阻害する
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] マイクロRNAプロセシング因子の制御による腫瘍溶解性アデノウイルスの機能向上
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、藤原俊義、水口裕之
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  慶應義塾大学薬学部　芝共立キャンパス（東京都港区）
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルスベクターワクチンにより誘導されるⅠ型IFNシグナルを介した腸管粘膜免疫誘導のメカニズム解明
- Author(s)
  辺見昌久、立花雅史、続木沙也加、庄司正樹、櫻井文教、川端健二、小檜山康司、石井健、審良静男、水口裕之
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  慶應義塾大学薬学部　芝共立キャンパス（東京都港区）
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Development of a novel oncolytic adenovirus expressing a short-hairpin RNA against a microRNA processing factor
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Masashi Tachibana, Toshiyoshi Fujiwara, Hiroyuki Mizuguchi
- Organizer
  第73回日本癌学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] MICRORNA PROCESSING FACTORS REGULATE ADENOVIRUS REPLICATION
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第20回日本遺伝子治療学会総会
- Place of Presentation
  慈恵医科大学（東京都港区）
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Activity levels of cathepsin B and L are crucial factors determining reovirus-mediated tumor cell lysis
- Author(s)
  Fuminori Sakurai, Yuki Katayama, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第73回日本癌学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26293118

1. SAKURAI FUMINORI (70370939)

# of Collaborated Projects: 5 results

# of Collaborated Products: 83 results
2. Mizuguchi Hiroyuki (50311387)

# of Collaborated Projects: 3 results

# of Collaborated Products: 84 results
3. 小山正平 (80767559)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Wada Koichiro (90263467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 中島淳 (30326037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 今城健人 (30600192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 田中徹也 (10346380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 原田和生 (50397741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 岡田欣晃 (50444500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 藤尾慈 (20359839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 鎌田春彦 (00324509)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 川上茂 (20322307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 清水かほり (50737749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 中村紳一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tachibana Masashi 立花 雅史

TACHIBANA Masashi 立花 雅史

Research Projects

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Efficient Drug Targeting by oncolytic virus-meidated tumor-specific expression of artificial receptors

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血管を経由する新発想での臓器の脱線維化技術の開発

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Regulation of myeloid-derived suppressor cells by palmitic acid metabolism for next-generation cancer immunotherapyPrincipal Investigator

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Elucidation of oncolytic virus-mediated intratumorl infiltration of immune cells and development of further promotion methods

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Elucidation of the regulatory mechanisms myeloid-derived suppressor cells by lipid metabolism and its application to cancer therapyPrincipal Investigator

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Mechanisms of induction of mucosal immunity by adenovirus vector vaccinePrincipal Investigator

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Prediction and prevention of serious systemic diseases induced by local infection of bacteria

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The development of novel adenovirus vectors and application for treatment, prevention, and diagnosis of diseases

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Development of a novel oncolytic virus by regulating the processing of virus-derived non-coding RNA

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Elucidation of the molecular mechanisms of immunological tolerance in liverPrincipal Investigator

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Foxp3変異マウスを用いた制御性T細胞機能解析Principal Investigator

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[Journal Article] Adoptively Transferred Myeloid-Derived Suppressor Cells Decrease Influenza A Virus Infection Mortality in a Mouse Model2024

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[Journal Article] Modified method for differentiation of myeloid-derived suppressor cells in vitro enhances immunosuppressive ability via glutathione metabolism2023

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Tachibana Masashi 立花雅史

TACHIBANA Masashi 立花雅史