KIKUCHI SHOHEI 菊地尚平

… Alternative Names

Kikuchi Shohei 菊地尚平

KIKUCHI Shohei 菊地尚平

菊池尚平キクチショウヘイ

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Researcher Number	80515792
Other IDs	https://orcid.org/0000-0002-0961-6253
Affiliation (Current)	2025: 富山大学, 学術研究部医学系, 講師 2025: 札幌医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 富山大学, 学術研究部医学系, 特命助教 2016 – 2021: 札幌医科大学, 医学部, 助教 2020: 富山大学, 附属病院, 特命助教 2014: 札幌医科大学, 医学部, 助教 2009 – 2011: 札幌医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Hematology Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Hematology / Basic Section 54010:Hematology and medical oncology-related / Basic Section 53010:Gastroenterology-related / Gastroenterology
Keywords	Principal Investigator IAP阻害剤 / アポトーシス / 多発性骨髄腫 / IAP / ●血液腫瘍 / アポトーシス誘導 / HDAC阻害剤 Except Principal Investigator 白血病 / 骨髄異形成症候群 / CAR-NK … More / CAR-T / CD26 / 分子標的薬 / Hck / DPP9 / 治療開発 / バイオマーカー / 血液悪性腫瘍 / 阻害剤 / DPP8 / 骨髄リプログラミング / エクソソーム / リプログラミング / PD-MSC / YAP1 / iPS細胞 / 急性骨髄性白血病 / PCBP1 / STK4 / HIPPO / miR-7977 / マイクロRNA / 骨髄間葉系幹細胞 / 細胞外小胞 / 薬物搬送 / 治療 / 相乗効果 / ヒストン脱アセチル化酵素 / 化学療法 / 肝細胞癌 / ● / 膵がん / エピジェネティクス / FOXO3a / 細胞周期 / 細胞周期停止 / 膵癌 / HDAC阻害剤 / 腫瘍幹細胞 / ゲノム / 予後因子 / 活性酸素 / HPLC-ECD / 幹細胞 / 鉄キレート剤 / 酸化的DNA損傷 / 鉄キレート / 8-OHdG / MDS / 発現制御 / 臨床 / シグナル伝達 / 内科 / 癌 Less

T細胞性血液がんのCD26を標的とする新たな遺伝子改変がん免疫療法の開発
- Principal Investigator
  
  佐藤勉
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  University of Toyama
Development of the treatment for hematologic malignancies using a novel DPP8 inhibitor and identification of biomarkers
- Principal Investigator
  
  Sato Tsutomu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  University of Toyama
Analysis of the development and pathogenesis of AML/MDS via extracellular vesicles
- Principal Investigator
  
  Kobune Masayoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Sapporo Medical University
Simultaneous XIAP and cIAP1/2 inhibition by AZD5582 induces apoptosis in multiple myelomaPrincipal Investigator
- Principal Investigator
  
  Kikuchi Shohei
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  University of Toyama
  Sapporo Medical University
Development of novel treatment for liver cancer with class-selective HDAC inhibitors
- Principal Investigator
  
  Miyanishi Koji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Sapporo Medical University
HDAC inhibition against pancreatic cancer
- Principal Investigator
  
  Michihiro Ono
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
selective HDAC class IIa inhibition against myelomaPrincipal Investigator
- Principal Investigator
  
  Kikuchi Shohei
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Sapporo Medical University
Establishment of iron chelation therapy to inhibit the development of MDS
- Principal Investigator
  
  KOBUNE Masayoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Sapporo Medical University
Development of dual targeting therapy for cancer stem cells and niche
- Principal Investigator
  
  KOBUNE Masayoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Sapporo Medical University

All 2023 2021 2020 2019 2014 2012 2010 Other

All Journal Article Presentation

[Journal Article] DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies2023
- Author(s)
  Kikuchi S, Wada A, Kamihara Y, Okazaki K, Jawaid P, Rehman MU, Kobayashi E, Susukida T, Minemura T, Nabe Y, Iwao N, Ozawa T, Hatano R, Yamada M, Kishi H, Matsuya Y, Mizuguchi M, Hayakawa Y, Dang NH, Sakamoto Y, Morimoto C, Sato T
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 7 Pages: 1100-1100
- DOI
  10.3390/cells12071100
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18261, KAKENHI-PROJECT-23K06501, KAKENHI-PROJECT-21K07237, KAKENHI-PROJECT-21H02782, KAKENHI-PROJECT-23K27395, KAKENHI-PROJECT-23K27423
[Journal Article] Possible clinical outcomes using early enteral nutrition in individuals with allogeneic hematopoietic stem cell transplantation: A single-center retrospective study2021
- Author(s)
  Satoshi Iyama, Hiroomi Tatsumi, Tsukasa Shiraishi, Shohei Kikuchi, Tsutomu Sato, Hirofumi Ohnishi, Shin-Ichi Yokota, Masayoshi Kobune
- Journal Title
  
  Nutrition
  
  Volume: 83 Pages: 111093-111093
- DOI
  10.1016/j.nut.2020.111093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23921, KAKENHI-PROJECT-19K08871
[Journal Article] Diffuse large B cell lymphoma with HIV infection presented with disseminated thromboembolism during antiretroviral therapy2020
- Author(s)
  池田博、井山諭、加藤淳二、小船雅義、長島加奈、藤田千紗、後藤亜香利、堀口拓人、菊地尚平、村瀬和幸、高田弘一
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 61 Issue: 11 Pages: 1595-1599
- DOI
  10.11406/rinketsu.61.1595
- NAID
  130007951912
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08871
[Journal Article] EPO-R+ myelodysplastic cells with ring sideroblasts produce high erythroferrone levels to reduce hepcidin expression in hepatic cells2019
- Author(s)
  Miura, S. Kobune, M. Horiguchi, H. Kikuchi, S. Iyama, S. Murase, K. Goto, A. Ikeda, H. Takada, K. Miyanishi, K. Kato, J.
- Journal Title
  
  Blood Cells Mol Dis
  
  Volume: 78 Pages: 1-8
- DOI
  10.1016/j.bcmd.2019.04.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08871
[Journal Article] miR-7977 inhibits the Hippo-YAP signaling pathway in bone marrow mesenchymal stromal cells2019
- Author(s)
  Yoshida, M. Horiguchi, H. Kikuchi, S. Iyama, S. Ikeda, H. Goto, A. Kawano, Y. Murase, K. Takada, K. Miyanishi, K. Kato, J. Kobune, M.
- Journal Title
  
  PLoS One
  
  Volume: 14 Issue: 3 Pages: e0213220-e0213220
- DOI
  10.1371/journal.pone.0213220
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08871
[Journal Article] Narrowband ultraviolet B phototherapy ameliorates acute graft-versus-host disease by a mechanism involving in vivo expansion of CD4+CD25+Foxp3+ regulatory T cells．2014
- Author(s)
  Iyama S，Murase K，Sato T，Hashimoto A，Tatekoshi A，Horiguchi H，Kamihara Y，Ono K，Kikuchi S，Takada K，Kawano Y，Hayashi T，Miyanishi K，Sato Y，Takimoto R，Kobune M，Mori S，Kato J，Yamashita T，Kato J．
- Journal Title
  
  Int J Hematol
  
  Volume: 99 Issue: 4 Pages: 471-476
- DOI
  10.1007/s12185-014-1530-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591427, KAKENHI-PROJECT-24659466, KAKENHI-PROJECT-25461705
[Journal Article] A novel strategy inducing autophagic cell death in Burkitt’s lymphoma cells with anti-CD19-targeted liposomal rapamycin.2014
- Author(s)
  Ono K, Sato T, Iyama S, Tatekoshi A, Hashimoto A, Kamihara Y, Horiguchi H, Kikuchi S, Kawano Y,Takada K, Hayashi T, Miyanishi K, Sato Y, Takimoto R, Kobune M, Kato J.
- Journal Title
  
  Blood Cancer J
  
  Volume: 7 Issue: 2 Pages: e180-e180
- DOI
  10.1038/bcj.2014.2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591403, KAKENHI-PROJECT-24659372, KAKENHI-PROJECT-24659466
[Journal Article] Improvement of iron-mediated oxidative DNA damage in patients with transfusion-dependent myelodysplastic syndrome by treatment with deferasirox.2012
- Author(s)
  Kikuchi S, Kobune M, Iyama S, Sato T, Murase K, Kawano Y, Takada K, Ono K, Kaneko Y, Miyanishi K, Sato Y, Hayashi T, Takimoto R, Kato J.
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 23(6) Issue: 4 Pages: 548-550
- DOI
  10.1016/j.freeradbiomed.2012.06.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890169, KAKENHI-PROJECT-24590985, KAKENHI-PROJECT-24659466
[Journal Article] Prognostic significance of serum-ferritin level at diagnosis in myelodysplastic syndrome2012
- Author(s)
  Kobune M, et al. 2^<nd>
- Journal Title
  
  Int J Hematol
  
  Volume: (In press) Issue: 5 Pages: 527-534
- DOI
  10.1007/s12185-012-1048-3
- NAID
  10030633185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591213, KAKENHI-PROJECT-23890169, KAKENHI-PROJECT-24659372, KAKENHI-PROJECT-24659466
[Presentation] 骨髄異形成症候群を増悪させる環境因子の解析2014
- Author(s)
  小船雅義，堀口拓人，定免渉，菊地尚平，村瀬和幸，井山　諭，高田弘一，
- Organizer
  第56回日本血液科学会秋季北海道地方会シンポジウム
- Place of Presentation
  北海道大学（北海道, 札幌市）
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-24659466
[Presentation] SMO阻害剤は急性骨髄性白血病細胞の薬剤耐性を解除する2010
- Author(s)
  小船雅義, 村瀬和幸, 井山諭, 佐藤勉, 瀧本理修, 菊地尚平, 宮西浩嗣, 佐藤康史, 加藤淳二
- Organizer
  第14回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21591213
[Presentation] Exosomes derived from AML/MDS cells could be involved in stromal dysfunction and bone marrow failure
- Author(s)
  Jomen W, Horiguchi H, Kobune M, Kikuchi S, Murase K, Ibata S, Iyama S, Sato T, Kamihara Y, Miyanishi K, Sato Y, Hayashi T, Takimoto R, Kato J
- Organizer
  2015 Highlights of ASH in Asia
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2015-02-28 – 2015-03-01
- Data Source
  KAKENHI-PROJECT-24659466
[Presentation] Exosomes derived from AML/MDS cells could be involved in stromal dysfunction and bone marrow failure.
- Author(s)
  Horiguchi H, Kobune M, Kikuchi S, Jomen W, Murase K, Ibata S, Iyama S, Sato T, Kamihara Y, Miyanishi K, Sato Y, Hayashi T, Takimoto R, Kato J.
- Organizer
  56th ASH Annual Meeting and Exposition
- Place of Presentation
  San Francisco, U.S.A
- Year and Date
  2014-12-06 – 2014-12-11
- Data Source
  KAKENHI-PROJECT-24659466

1. KATO Junji (20244345)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. KOBUNE Masayoshi (90336389)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
3. IYAMA Satoshi (50398319)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
4. Miyanishi Koji (60372819)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Sato Tsutomu (40404602)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 和田暁法 (60775922)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 神原悠輔 (10624421)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. TAKIMOTO Rishu (10336399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. Michihiro Ono (80634675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 宇佐美信 (10773377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 田中信悟 (60561024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 池田博 (60570132)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. 後藤亜香利 (60722387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 岸裕幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 高田弘一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KIKUCHI SHOHEI 菊地 尚平

Kikuchi Shohei 菊地 尚平

KIKUCHI Shohei 菊地 尚平

菊池 尚平 キクチ ショウヘイ

Research Projects

Research Products

Co-Researchers

T細胞性血液がんのCD26を標的とする新たな遺伝子改変がん免疫療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of the treatment for hematologic malignancies using a novel DPP8 inhibitor and identification of biomarkers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the development and pathogenesis of AML/MDS via extracellular vesicles

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Simultaneous XIAP and cIAP1/2 inhibition by AZD5582 induces apoptosis in multiple myelomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel treatment for liver cancer with class-selective HDAC inhibitors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

HDAC inhibition against pancreatic cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

selective HDAC class IIa inhibition against myelomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of iron chelation therapy to inhibit the development of MDS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of dual targeting therapy for cancer stem cells and niche

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Possible clinical outcomes using early enteral nutrition in individuals with allogeneic hematopoietic stem cell transplantation: A single-center retrospective study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diffuse large B cell lymphoma with HIV infection presented with disseminated thromboembolism during antiretroviral therapy2020

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] EPO-R+ myelodysplastic cells with ring sideroblasts produce high erythroferrone levels to reduce hepcidin expression in hepatic cells2019

KIKUCHI SHOHEI 菊地尚平

Kikuchi Shohei 菊地尚平

KIKUCHI Shohei 菊地尚平

菊池尚平キクチショウヘイ