mizuno tomoaki 水野智亮

… Alternative Names

水野智亮ミズノトモアキ

MIZUNO Tomoaki 水野智亮

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Researcher Number	80529032
Other IDs
Affiliation (Current)	2025: 筑波大学, 医学医療系, 准教授
Affiliation (based on the past Project Information) *help	2023: 筑波大学, 医学医療系, 准教授 2019 – 2021: 筑波大学, 医学医療系, 准教授 2011 – 2018: 筑波大学, 医学医療系, 助教 2009 – 2010: University of Tsukuba, 大学院・人間総合科学研究科, 助教
Review Section/Research Field	Principal Investigator Cell biology / Basic Section 44010:Cell biology-related
Keywords	Principal Investigator 小胞体ストレス / キナーゼ / 遺伝子発現制御 / ホスファターゼ / 転写因子 / 小胞体ストレス応答 / シグナル伝達 / 出芽酵母 / オートファジー / 発現制御 … More / 遺伝学 / ストレス / フィードバック / AMPK / AMP活性化キナーゼ / MAPキナーゼ / 小胞体輸送 / ストレス応答 / 細胞内情報伝達 / Notch / ゼブラフィッシュ Less

出芽酵母小胞体ストレス応答に機能する転写因子の抽出と解析Principal Investigator
- Principal Investigator
  
  水野智亮
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  University of Tsukuba
Comprehensive analysis of kinases and phosphatases that regulate the endoplasmic reticulum stress response in the budding yeastPrincipal Investigator
- Principal Investigator
  
  Mizuno Tomoaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  University of Tsukuba
Regulation of Hog1 MAPK by Snf1 AMPK in yeast ER stress responsePrincipal Investigator
- Principal Investigator
  
  Tomoaki Mizuno
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  University of Tsukuba
Elucidation of the kinase module to control the endoplasmic reticulum stress responsePrincipal Investigator
- Principal Investigator
  
  Mizuno Tomoaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  University of Tsukuba
Elucidation of a molecular network regulating transport and quality control of proteinPrincipal Investigator
- Principal Investigator
  
  MIZUNO Tomoaki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  University of Tsukuba
A novel function of Jagged in the zebrafish lateral line developmentPrincipal Investigator
- Principal Investigator
  
  MIZUNO Tomoaki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  University of Tsukuba

All 2023 2021 2020 2019 2018 2017 2015 2013 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] Pbp1 mediates the aberrant expression of genes involved in growth defect of ccr4 and pop2 mutants in yeast Saccharomyces cerevisiae2021
- Author(s)
  Valderrama Arvin Lapiz、Fujii Shiori、Duy Duong Long、Irie Kaoru、Mizuno Tomoaki、Suda Yasuyuki、Irie Kenji
- Journal Title
  
  Genes to Cells
  
  Volume: - Issue: 6 Pages: 381-398
- DOI
  10.1111/gtc.12846
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06632, KAKENHI-PROJECT-18K06053, KAKENHI-PROJECT-21K06145, KAKENHI-PROJECT-18H05275
[Journal Article] The eIF4E-binding protein Eap1 has similar but independent roles in cell growth and gene expression with the cytoplasmic deadenylase Ccr42021
- Author(s)
  Higuchi Yudai、Fujii Shiori、Valderrama Arvin Lapiz、Irie Kaoru、Suda Yasuyuki、Mizuno Tomoaki、Irie Kenji
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: - Issue: 6 Pages: 1452-1459
- DOI
  10.1093/bbb/zbab056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06632, KAKENHI-PROJECT-18K06053, KAKENHI-PROJECT-21K06145, KAKENHI-PROJECT-18H05275
[Journal Article] Msn2/4 transcription factors positively regulate expression of Atg39 ER-phagy receptor2021
- Author(s)
  Mizuno Tomoaki、Irie Kenji
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 11919-11919
- DOI
  10.1038/s41598-021-91480-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06632
[Journal Article] Pan2-Pan3 complex, together with Ccr4-Not complex, has a role in the cell growth on non-fermentable carbon sources2021
- Author(s)
  Fujii Shiori、Duy Duong Long、Valderrama Arvin Lapiz、Takeuchi Risa、Matsuura Eri、Ito Ayaka、Irie Kaoru、Suda Yasuyuki、Mizuno Tomoaki、Irie Kenji
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 570 Pages: 125-130
- DOI
  10.1016/j.bbrc.2021.07.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06632, KAKENHI-PROJECT-21K06145, KAKENHI-PROJECT-18H05275
[Journal Article] Pbp1, the yeast ortholog of human Ataxin-2, functions in the cell growth on non-fermentable carbon sources.2021
- Author(s)
  Tuong Vi DT, Fujii S, Valderrama AL, Ito A, Matsuura E, Nishihata A, Irie K, Suda Y, Mizuno T, Irie K.
- Journal Title
  
  PLOS ONE
  
  Volume: in press Issue: 5 Pages: e0251456-e0251456
- DOI
  10.1371/journal.pone.0251456
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06053, KAKENHI-PROJECT-19K06632, KAKENHI-PROJECT-21K06145, KAKENHI-PROJECT-18H05275
[Journal Article] Snf1 AMPK positively regulates ER-phagy via expression control of Atg39 autophagy receptor in yeast ER stress response2020
- Author(s)
  Mizuno Tomoaki、Muroi Kei、Irie Kenji
- Journal Title
  
  PLOS Genetics
  
  Volume: 16 Issue: 9 Pages: e1009053-e1009053
- DOI
  10.1371/journal.pgen.1009053
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06632, KAKENHI-PROJECT-18K06053
[Journal Article] Pop2 Phosphorylation at S39 Contributes to the Glucose Repression of Stress Response Genes, HSP12 and HSP262019
- Author(s)
  Lien PTK, Viet NTM, Mizuno T, Suda Y, Irie K.
- Journal Title
  
  PLoS One
  
  Volume: 14 Issue: 4 Pages: e0215064-e0215064
- DOI
  10.1371/journal.pone.0215064
- NAID
  120007133492
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06053, KAKENHI-PROJECT-19K06632, KAKENHI-PROJECT-17K07377
[Journal Article] Induction of Ptp2 and Cmp2 protein phosphatases is crucial for the adaptive response to ER stress in Saccharomyces cerevisiae.2018
- Author(s)
  Mizuno T, Nakamura M, Irie K.
- Journal Title
  
  Sci Rep.
  
  Volume: 8 Issue: 1 Pages: 13078-13078
- DOI
  10.1038/s41598-018-31413-6
- NAID
  120007133846
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06053, KAKENHI-PROJECT-16K07336
[Journal Article] Expression control of the AMPK regulatory subunit and its functional significance in yeast ER stress response2017
- Author(s)
  Yuichi Kimura, Kenji Irie, Tomoaki Mizuno
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中
- NAID
  120007129143
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K07336
[Journal Article] The Saccharomyces cerevisiae AMPK, Snf1, Negatively Regulates the Hog1 MAPK Pathway in ER Stress Response.2015
- Author(s)
  Mizuno T, Masuda Y, Irie K
- Journal Title
  
  PLOS Genetics
  
  Volume: 11 Issue: 9 Pages: e1005491-e1005491
- DOI
  10.1371/journal.pgen.1005491
- NAID
  120007136050
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06944, KAKENHI-PROJECT-25440078
[Journal Article] The Caenorhabditis elegans JNK signaling pathway activates expression of stress response genes by derepressing the Fos/HDAC repressor complex2013
- Author(s)
  Hattori A, Mizuno T, Akamatsu M, Hisamoto N, Matsumoto K
- Journal Title
  
  PLoS Genet
  
  Volume: 9(2)
- NAID
  120007137023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770217
[Journal Article] The C. elegans growth factor-receptor tyrosine kinase signalling regulates axon regeneration2012
- Author(s)
  Li C, Hisamoto N, Nix P, Kanao S, Mizuno T, Bastiani M, Matsumoto K
- Journal Title
  
  Nature Neuroscience
  
  Volume: 15(4) Pages: 551-557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770217
[Journal Article] The growth factor SVH-1 regulates axon regeneration in C.elegans via the JNK MAPK cascade2012
- Author(s)
  Chun Li
- Journal Title
  
  Nature Neuroscience
  
  Volume: 15 Issue: 4 Pages: 551-557
- DOI
  10.1038/nn.3052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J09457, KAKENHI-PROJECT-21247031, KAKENHI-PUBLICLY-23117708, KAKENHI-PROJECT-23590331, KAKENHI-PROJECT-23770217, KAKENHI-PROJECT-24247025
[Journal Article] RNA-binding protein Khd1 and Ccr4 deadenylase play an overlapping role in the cell wall integrity pathway in yeast2011
- Author(s)
  Ito, et al
- Journal Title
  
  Eukaryotic Cell
  
  Volume: 10 Issue: 10 Pages: 1340-1347
- DOI
  10.1128/ec.05181-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10F00395, KAKENHI-PROJECT-21370077, KAKENHI-PUBLICLY-22020004, KAKENHI-PROJECT-23770217
[Journal Article] RNA-binding protein Khd1 and Ccr4 deadenylase play an overlapping role in the cell wall integrity pathway in yeast2011
- Author(s)
  Ito W, Li X, Irie K, Mizuno T, Irie K
- Journal Title
  
  Eukaryotic Cell
  
  Volume: 10(10) Pages: 1340-1347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770217
[Journal Article] The Caenorhabditis elegans Ste20-Related Kinase and Rac-Type Small GTPase Regulate the c-Jun N-Terminal Kinase Signaling Pathway Mediating the Stress Response.2010
- Author(s)
  Kota Fujiki, Tomoaki Mizuno, Naoki Hisamoto, Kunihiro Matsumoto
- Journal Title
  
  Molecular and Cellular Biology 30(4)
  
  Pages: 995-1003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770201
[Journal Article] The Caenorhabditis elegans Ste20-Related Kinase and Rac-Type Small GTPase Regulate the c-Jun N-Terminal Kinase Signaling Pathway Mediating the Stress Response2010
- Author(s)
  Fujiki K, Mizuno T, Hisamoto N, Matsumoto K.
- Journal Title
  
  Molecular and Cellular Biology 30
  
  Pages: 995-1003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770201
[Presentation] 小胞体ストレス下におけるRGGモチーフタンパク質の寄与とその制御機構の解明2023
- Author(s)
  遠藤雅、入江賢児、水野智亮
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K05761
[Presentation] ERストレス下におけるRGGモチーフタンパク質Sbp1の重要性2023
- Author(s)
  遠藤雅、入江賢児、水野智亮
- Organizer
  第56回酵母遺伝学フォーラム研究報告会
- Data Source
  KAKENHI-PROJECT-23K05761
[Presentation] RGG-motifタンパク質による小胞体ストレス応答の制御2021
- Author(s)
  遠藤雅、入江賢児、水野智亮
- Organizer
  酵母遺伝学フォーラム第54回研究報告会
- Data Source
  KAKENHI-PROJECT-19K06632
[Presentation] 出芽酵母の小胞体ストレス応答に関与するキナーゼ群の探索2018
- Author(s)
  高田奈苗・入江賢児・水野智亮
- Organizer
  酵母遺伝学フォーラム第５１回研究報告会
- Data Source
  KAKENHI-PROJECT-16K07336
[Presentation] 出芽酵母小胞体ストレス応答における転写因子Sfp1を介したリボソーム発現制御の生理学的意義2018
- Author(s)
  高木亮輔・入江賢児・水野智亮
- Organizer
  酵母遺伝学フォーラム第５１回研究報告会
- Data Source
  KAKENHI-PROJECT-16K07336
[Presentation] 出芽酵母小胞体ストレスにおけるAMPK制御サブユニットの発現制御と機能2017
- Author(s)
  木村雄一、入江賢児、水野智亮
- Organizer
  第５０回酵母遺伝学フォーラム研究報告会
- Data Source
  KAKENHI-PROJECT-16K07336
[Presentation] 重金属ストレス応答において線虫JNKは転写因子Fosを負に制御する2012
- Author(s)
  服部鮎奈、水野智亮、赤松まゆ子、久本直毅、松本邦弘
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-23770217
[Presentation] The KGB-1 JNK signaling pathway negatively regulates FOS-1 transcription factor in stress response2011
- Author(s)
  Ayuna Hattori, Tomoaki Mizuno, Naoki Hisamoto, Kunihiro Matsumoto
- Organizer
  第18回国際線虫学会
- Place of Presentation
  アメリカ合衆国
- Year and Date
  2011-06-24
- Data Source
  KAKENHI-PROJECT-23770217
[Presentation] 線虫新規増殖因子SVH-1とその受容体チロシンキナーゼSVH-2はJNK型MAPK経路を介して神経軸索再生を制御する2011
- Author(s)
  李春,久本直毅,Nix Paola,金尾朱夏,水野智亮,Bastiani Michael,松本邦弘
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-23770217
[Presentation] 重金属ストレス応答において線虫JNKは転写因子Fosを負に制御する2011
- Author(s)
  服部鮎奈、水野智亮、久本直毅、松本邦弘
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-23770217
[Presentation] 線虫JNK経路を介した遺伝子発現制御におけるHDACの機能解析2011
- Author(s)
  赤松まゆ子,服部鮎奈,水野智亮,久本直毅,松本邦弘
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-23770217
[Presentation] 線虫JNK経路を介した遺伝子発現制御におけるHDACの機能解析2011
- Author(s)
  赤松まゆ子，服部鮎奈，水野智亮，久本直毅，松本邦弘
- Organizer
  日本分子生物学会第３４回年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23770217
[Presentation] 線虫新規増殖因子SVH-1とその受容体チロシンキナーゼSVH-2はJNK型MAPK経路を介して神経軸索再生を制御する2011
- Author(s)
  李春，久本直毅，Nix Paola，金尾朱夏，水野智亮，Bastiani Michael，松本邦弘
- Organizer
  日本分子生物学会第３４回年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23770217
[Presentation] 重金属ストレス応答において線虫JNKは転写因子Fosを負に制御する2011
- Author(s)
  服部鮎奈，水野智亮，久本直毅，松本邦弘
- Organizer
  日本分子生物学会第３４回年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23770217
[Presentation] 線虫をモデル動物とした神経再生を誘導する因子/受容体の解析2010
- Author(s)
  李春、久本直毅、水野智亮、松本邦弘
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21770201
[Presentation] The C.elegans JNK signaling pathway regulates FOS-1 transcription factor in stress response2010
- Author(s)
  Ayuna Hattori, Tomoaki Mizuno, Naoki Hisamoto, Kunihiro Matsumoto
- Organizer
  East Asia Worm Meeting
- Place of Presentation
  Tokyo, JAPAN
- Data Source
  KAKENHI-PROJECT-21770201
[Presentation] 線虫JNKは転写因子Fosをリン酸化し負に制御する2009
- Author(s)
  服部鮎奈、水野智亮、久本直毅、松本邦弘
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21770201
[Presentation] KGB-1, a JNK-like MAPK, negatively regulates FOS-1 transcription factor in stress response2009
- Author(s)
  Ayuna Hattori, Tomoaki Mizuno, Naoki Hisamoto, Kunihiro Matsumoto
- Organizer
  International Worm Meeting
- Place of Presentation
  Los Angeles, USA
- Data Source
  KAKENHI-PROJECT-21770201
[Presentation] C.elegans MLK-1 MAPKKK is regulated by double phosphorylation in JNK-mediated stress response pathway2009
- Author(s)
  Kota Fujiki, Tomoaki Mizuno, Naoki Hisamoto, Kunihiro Matsumoto
- Organizer
  International Worm Meeting
- Place of Presentation
  Los Angeles, USA
- Data Source
  KAKENHI-PROJECT-21770201

1. 入江賢児

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
2. 須田恭之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

mizuno tomoaki 水野 智亮

水野 智亮 ミズノ トモアキ

MIZUNO Tomoaki 水野 智亮

Research Projects

Research Products

Co-Researchers

出芽酵母小胞体ストレス応答に機能する転写因子の抽出と解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive analysis of kinases and phosphatases that regulate the endoplasmic reticulum stress response in the budding yeastPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of Hog1 MAPK by Snf1 AMPK in yeast ER stress responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the kinase module to control the endoplasmic reticulum stress responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of a molecular network regulating transport and quality control of proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A novel function of Jagged in the zebrafish lateral line developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pbp1 mediates the aberrant expression of genes involved in growth defect of ccr4 and pop2 mutants in yeast Saccharomyces cerevisiae2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The eIF4E-binding protein Eap1 has similar but independent roles in cell growth and gene expression with the cytoplasmic deadenylase Ccr42021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Msn2/4 transcription factors positively regulate expression of Atg39 ER-phagy receptor2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pan2-Pan3 complex, together with Ccr4-Not complex, has a role in the cell growth on non-fermentable carbon sources2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pbp1, the yeast ortholog of human Ataxin-2, functions in the cell growth on non-fermentable carbon sources.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Snf1 AMPK positively regulates ER-phagy via expression control of Atg39 autophagy receptor in yeast ER stress response2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pop2 Phosphorylation at S39 Contributes to the Glucose Repression of Stress Response Genes, HSP12 and HSP262019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Induction of Ptp2 and Cmp2 protein phosphatases is crucial for the adaptive response to ER stress in Saccharomyces cerevisiae.2018

Author(s)

mizuno tomoaki 水野智亮

水野智亮ミズノトモアキ

MIZUNO Tomoaki 水野智亮