Uruno Takehito 宇留野武人

… Alternative Names

URUNO Takehito 宇留野武人

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Researcher Number	80532093
Other IDs	https://orcid.org/0000-0002-2812-9645
Affiliation (Current)	2024: 九州大学, 生体防御医学研究所, 准教授
Affiliation (based on the past Project Information) *help	2013 – 2023: 九州大学, 生体防御医学研究所, 准教授
Review Section/Research Field	Principal Investigator Basic Section 43030:Functional biochemistry-related / Tumor biology Except Principal Investigator Functional biochemistry / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Keywords	Principal Investigator 腫瘍免疫 / 免疫回避 / 細胞骨格 / DOCK1 / がん / 免疫特権 / 腫瘍微小環境 / DOCK2 / SULT2B1b / がん免疫療法 … More / 創薬 / コレステロール硫酸 / コレステロール / メタボライト / 治療抵抗性 / インターフェロン / 腫瘍 / 分子標的 / 炎症制御 / 低分子量Gタンパク質 / シグナル伝達 / 腫瘍制御 / 抗がん剤 / 阻害化合物 / 転移 / 浸潤 / マクロピノサイトーシス / 浸潤転移 / Ras / Rac / 阻害剤 / 浸潤・転移 … More Except Principal Investigator 生体分子 / 生理活性資質 / 酵素 / 生体機能 / 生理活性脂質 / 遺伝子発現 / 遺伝子 / 発現制御 / 低分子量Gタンパク質 / 免疫 / がん / 遺伝子改変マウス / 免疫学 / 癌 / シグナル伝達 Less

腫瘍の免疫特権環境形成における硫酸化コレステロールの役割と創薬応用Principal Investigator
- Principal Investigator
  
  宇留野武人
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Kyushu University
Analyses for expression and function of the sulfotransferase SULT2B1b
- Principal Investigator
  
  Fukui Yoshinori
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Kyushu University
Role of the Rac activator DOCK1 in immune evasion by tumorPrincipal Investigator
- Principal Investigator
  
  Uruno Takehito
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Kyushu University
Molecular basis for Jmjd6-mediated control of Aire protein expression and its evolutional insight
- Principal Investigator
  
  Fukui Yoshinori
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kyushu University
Role of DOCK family proteins in malignant transformation by human oncogenic RacPrincipal Investigator
- Principal Investigator
  
  Uruno Takehito
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kyushu University
Comprehensive analyses for biological functions and regulatory mechanisms of DOCK family proteins
- Principal Investigator
  
  Fukui Yoshinori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kyushu University

All 2022 2021 2019 2018 2017 2016 2015 2014

All Journal Article Presentation Patent

[Journal Article] Pharmacological intervention of cholesterol sulfate-mediated T cell exclusion promotes antitumor immunity2022
- Author(s)
  Takaaki Tatsuguchi, Takehito Uruno, Yuki Sugiura, Kounosuke Oisaki, Daisuke Takaya, Daiji Sakata, Yoshihiro Izumi, Takaya Togo, Yuko Hattori, Kazufumi Kunimura, Testuya Sakurai, Teruki Honma, Takeshi Bamba, Masafumi Nakamura, Motomu Kanai, Makoto Suematsu, Yoshinori Fukui
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H00983
[Journal Article] Cancer-derived cholesterol sulfate is a key mediator to prevent tumor infiltration by effector T cells2022
- Author(s)
  Tatsuguchi T., Uruno T., Sugiura Y., Sakata D., Izumi Y., Sakurai T., Hattori Y., Oki E., Kubota N., Nishimoto K., Oyama M., Kunimura K., Ohki T., Bamba T., Tahara H., Sakamoto M., Nakamura M., Suematsu M., Fukui Y.
- Journal Title
  
  Int. Immunol.
  
  Volume: － Issue: 5 Pages: 277-289
- DOI
  10.1093/intimm/dxac002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06304, KAKENHI-PROJECT-19H00983, KAKENHI-PROJECT-21H02430
[Journal Article] 2.論文標題 DOCK8 deficiency causes a skewing to type 2 immunity in the gut with expansion of group 2 innate lymphoid cells.2021
- Author(s)
  Matsubara K, Kunimura K, Yamane N, Aihara R, Sakurai T, Sakata D, Uruno T, Fukui Y
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 559 Pages: 135-140
- DOI
  10.1016/j.bbrc.2021.04.094
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H00983, KAKENHI-PROJECT-21H02430
[Journal Article] A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK82021
- Author(s)
  Sakurai Tetsuya、Kukimoto-Niino Mutsuko、Kunimura Kazufumi、Yamane Nana、Sakata Daiji、Aihara Ryosuke、Yasuda Tomoharu、Yokoyama Shigeyuki、Shirouzu Mikako、Fukui Yoshinori、Uruno Takehito
- Journal Title
  
  Life Science Alliance
  
  Volume: 4 Issue: 4 Pages: e202000873-e202000873
- DOI
  10.26508/lsa.202000873
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06575, KAKENHI-PROJECT-18H02669, KAKENHI-PROJECT-19K22538, KAKENHI-PROJECT-19H00983, KAKENHI-PROJECT-21H02751
[Journal Article] Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound.2021
- Author(s)
  Kamikaseda Y, Uruno T, Kunimura K, Harada A, Saiki K, Oisaki K, Sakata D, Nakahara T, Kido-Nakahara M, Kanai M, Nakamura S, Ohkawa Y, Furue M, Fukui Y.
- Journal Title
  
  J Allergy Clin Immunol.
  
  Volume: 148 Issue: 2 Pages: 633-638
- DOI
  10.1016/j.jaci.2021.03.029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21398, KAKENHI-PUBLICLY-20H04846, KAKENHI-PUBLICLY-20H05368, KAKENHI-PUBLICLY-21H00232, KAKENHI-PUBLICLY-21H00430, KAKENHI-PROJECT-19H00983, KAKENHI-PROJECT-20H00456, KAKENHI-PROJECT-19H03211, KAKENHI-PROJECT-21H02430
[Journal Article] DOCK8 controls survival of group 3 innate lymphoid cells in the gut through Cdc42 activation.2021
- Author(s)
  Aihara R, Kunimura K, Watanabe M, Uruno T, Yamane N, Sakurai T, Sakata D, Nishimura F, Fukui Y
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 3 Pages: 149-160
- DOI
  10.1093/intimm/dxaa066
- NAID
  120007166274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00983
[Journal Article] Selective role of neurokinin B in IL-31-induced itch response in mice2019
- Author(s)
  Sakata Daiji、Uruno Takehito、Matsubara Keisuke、Andoh Tsugunobu、Yamamura Kazuhiko、Magoshi Yuki、Kunimura Kazufumi、Kamikaseda Yasuhisa、Furue Masutaka、Fukui Yoshinori
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 144 Issue: 4 Pages: 1130-1133
- DOI
  10.1016/j.jaci.2019.06.031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02406, KAKENHI-PROJECT-19H00983
[Journal Article] S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer’s Patches2019
- Author(s)
  Kunimura K, Sakata D, Tun X, Uruno T, Ushijima M, Katakai T, Shiraishi A, Aihara R, Kamikaseda Y, Matsubara K, Kanegane H, Sawa S, Eberl G, Ohga S, Yoshikai Y, Fukui Y.
- Journal Title
  
  Cell Reports
  
  Volume: 29 Issue: 9 Pages: 2823-2834
- DOI
  10.1016/j.celrep.2019.10.091
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22528, KAKENHI-PROJECT-18H02406, KAKENHI-PROJECT-19H03483, KAKENHI-PROJECT-17K10099, KAKENHI-PROJECT-18K19503, KAKENHI-PLANNED-16H06496, KAKENHI-PROJECT-19H00983, KAKENHI-PLANNED-18H05417
[Journal Article] DOCK family proteins: key players in immune surveillance mechanisms2019
- Author(s)
  Kunimura Kazufumi、Uruno Takehito、Fukui Yoshinori
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 1 Pages: 5-15
- DOI
  10.1093/intimm/dxz067
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02406, KAKENHI-PROJECT-19H00983
[Journal Article] DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activation Rac1P29S mutation.2018
- Author(s)
  Tomino T, Tajiri H, Tatsuguchi T, Shirai T, Oisaki K, Matsunaga S, Sanematsu F, Sakata D, Yoshizumi T, Maehara Y, Kanai M, Cote JF, Fukui Y, Uruno T
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 497 Issue: 1 Pages: 298-304
- DOI
  10.1016/j.bbrc.2018.02.073
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02497, KAKENHI-PROJECT-16K15620, KAKENHI-PROJECT-18H02406, KAKENHI-PROJECT-16K08627, KAKENHI-PROJECT-15K08525
[Journal Article] The Rac activator DOCK2 mediates plasma cell differentiation and IgG antibody production.2018
- Author(s)
  Ushijima M, Uruno T, Nishikimi A, Sanematsu F, Kamikaseda Y, Kunimura K, Sakata D, Okada T, Fukui Y
- Journal Title
  
  Front Immunol.
  
  Volume: 9 Pages: 243-243
- DOI
  10.3389/fimmu.2018.00243
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02497, KAKENHI-PROJECT-18H02406, KAKENHI-PROJECT-16K08627, KAKENHI-PROJECT-15K08525
[Journal Article] Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye.2018
- Author(s)
  Sakurai T, Uruno T, Sugiura Y, Tatsuguchi T, Yamamura K, Ushijima M, Hattori Y, Kukimoto-Niino M, Mishima-Tumagari C, Watanabe M, Suematsu M, Fukui Y
- Journal Title
  
  Science Signaling
  
  Volume: 11 Issue: 541 Pages: 1-11
- DOI
  10.1126/scisignal.aao4874
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02497, KAKENHI-PROJECT-18H02406
[Journal Article] DOCK8 Regulates Macrophage Migration through Cdc42 Activation and LRAP35a Interaction.2017
- Author(s)
  Shiraishi A, Uruno T, Sanematsu F, Ushijima M, Sakata D, Hara T, Fukui Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 292 Issue: 6 Pages: 2191-2202
- DOI
  10.1074/jbc.m116.736306
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111007, KAKENHI-PROJECT-16H02497, KAKENHI-PROJECT-26430115, KAKENHI-PROJECT-15K08525, KAKENHI-PROJECT-16K08627
[Journal Article] Thymic epithelial cell-specific deletion of Jmjd6 reduces Aire protein expression and exacerbates disease development in a mouse model of autoimmune diabetes.2017
- Author(s)
  Yanagihara T, Tomino T, Uruno T, Fukui Y
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 489 Issue: 1 Pages: 8-13
- DOI
  10.1016/j.bbrc.2017.05.113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02497
[Journal Article] Targeting Ras-driven cancer cell survival and invasion through selective inhibition of DOCK12017
- Author(s)
  Tajiri H, Uruno T, Shirai T, Takaya D, Matsunaga S, Setoyama D, Watanabe M, Kukimoto-Niino M, Oisaki K, Ushijima M, Sanematsu F, Honma T, Terada T, Oki E, Shirasawa S, Maehara Y, Kang D, Cote J-F, Yokoyama S, Kanai M, Fukui Y
- Journal Title
  
  Cell Reports
  
  Volume: 19 Issue: 5 Pages: 969-980
- DOI
  10.1016/j.celrep.2017.04.016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430115, KAKENHI-PROJECT-15K06987, KAKENHI-PROJECT-16K08627, KAKENHI-PROJECT-16H02497, KAKENHI-PROJECT-17H01550
[Journal Article] The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.2017
- Author(s)
  Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y.
- Journal Title
  
  Nat Commun
  
  Volume: 8 Issue: 1 Pages: 13946-13946
- DOI
  10.1038/ncomms13946
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111007, KAKENHI-PROJECT-16H02497, KAKENHI-PROJECT-26293393, KAKENHI-PROJECT-26430115, KAKENHI-PROJECT-16K15792, KAKENHI-PROJECT-15K09669
[Journal Article] Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.2015
- Author(s)
  Yanagihara T, Sanematsu F, Sato T, Uruno T, Duan X, Tomino T, Harada Y, Watanabe M, Wang Y, Tanaka Y, Nakanishi Y, Suyama M, Yoshinori F.
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 8820-8820
- DOI
  10.1038/ncomms9820
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430115, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111007, KAKENHI-PROJECT-25251015, KAKENHI-PROJECT-26670287, KAKENHI-PROJECT-26670822, KAKENHI-PROJECT-26870420, KAKENHI-PROJECT-26293393
[Journal Article] DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation.2014
- Author(s)
  Ogawa K, Tanaka Y, Uruno T, Duan X, Harada Y, et al.
- Journal Title
  
  J. Exp. Med.
  
  Volume: (In press) Issue: 7 Pages: 1407-1419
- DOI
  10.1084/jem.20131926
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J03868, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111007, KAKENHI-PROJECT-24590586, KAKENHI-PUBLICLY-25111508, KAKENHI-PROJECT-25251015, KAKENHI-PROJECT-26293393, KAKENHI-PROJECT-26430115, KAKENHI-PROJECT-26670287, KAKENHI-PROJECT-26670822, KAKENHI-PROJECT-26860332, KAKENHI-PROJECT-26870420
[Journal Article] DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation.2014
- Author(s)
  Watanabe M, Terasawa M, Miyano K, Yanagihara T, Uruno T, Sanematsu F, Nishikimi A, Cote JF, Sumimoto H, Fukui Y.
- Journal Title
  
  J Immunol.
  
  Volume: 193 Issue: 11 Pages: 5660-5667
- DOI
  10.4049/jimmunol.1400885
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111007, KAKENHI-PROJECT-24590586, KAKENHI-PROJECT-25251015, KAKENHI-PLANNED-26111009, KAKENHI-PROJECT-26430115, KAKENHI-PROJECT-26670287, KAKENHI-PROJECT-26870420
[Journal Article] 免疫抑制剤開発の新しい分子標的としてのDOCK22014
- Author(s)
  宇留野武人
- Journal Title
  
  実験医学増刊
  
  Volume: 32 Pages: 184-189
- Data Source
  KAKENHI-PROJECT-25251015
[Patent] IL-31産生抑制剤、及びそれを含有する医薬組成物2022
- Inventor(s)
  福井宣規、宇留野武人、他
- Industrial Property Rights Holder
  福井宣規、宇留野武人、他
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-21H02430
[Patent] SULT2B1b阻害剤、CS生成阻害剤、及び抗がん免疫増強作用を有する医薬組成物2021
- Inventor(s)
  福井宣規、宇留野武人、他
- Industrial Property Rights Holder
  福井宣規、宇留野武人、他
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-173456
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21H02430
[Patent] IL-31介在性疾患の予防又は治療剤及び医薬組成物2019
- Inventor(s)
  福井宣規、坂田大治、宇留野武人
- Industrial Property Rights Holder
  福井宣規、坂田大治、宇留野武人
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18H02406
[Patent] DOCK1阻害化合物およびその用途2018
- Inventor(s)
  福井宣規、宇留野武人、金井求、生長幸之助、堤亮祐
- Industrial Property Rights Holder
  福井宣規、宇留野武人、金井求、生長幸之助、堤亮祐
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-225753
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18H02406
[Patent] アトピー性皮膚炎の予防又は治療剤及び医薬組成物2018
- Inventor(s)
  福井宣規、坂田大治、宇留野武人、安東嗣修
- Industrial Property Rights Holder
  福井宣規、坂田大治、宇留野武人、安東嗣修
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-215017
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18H02406
[Patent] ピリジノン化合物およびその用途2016
- Inventor(s)
  福井宣規、宇留野武人、他
- Industrial Property Rights Holder
  九州大学
- Industrial Property Rights Type
  特許
- Filing Date
  2016-02-26
- Overseas
- Data Source
  KAKENHI-PROJECT-26430115
[Patent] アトピー性皮膚炎モデル非ヒト動物及びその使用2016
- Inventor(s)
  福井宣規、山村和彦、宇留野武人、古江増隆、
- Industrial Property Rights Holder
  九州大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-034510
- Filing Date
  2016-02-25
- Data Source
  KAKENHI-PROJECT-25251015
[Patent] ピリジノン化合物及びその用途2015
- Inventor(s)
  福井宣規、宇留野武人、他
- Industrial Property Rights Holder
  福井宣規、宇留野武人、他
- Industrial Property Rights Type
  特許
- Filing Date
  2015-02-27
- Data Source
  KAKENHI-PROJECT-26430115
[Presentation] RAS変異を有する難治性がんの新規分子標的治療薬の開発2021
- Author(s)
  宇留野武人、坂田大治、福井宣規、生長幸之助
- Organizer
  第94回日本生化学会大会シンポジウム講演、京都, 2021
- Data Source
  KAKENHI-PROJECT-21H02430
[Presentation] The biological function of naturally occurring DOCK2 inhibitor in tissue-specific immune evasion2019
- Author(s)
  Sakurai T, Uruno T, Fukui Y
- Organizer
  American Association of Immunologist Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H00983
[Presentation] The biological function of naturally-occurring DOCK2 inhibitor in tissue-specific immune evasion.2019
- Author(s)
  Sakurai T, Uruno T, Fukui Y
- Organizer
  103rd Annual meeting of American Association of Immunologists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02406
[Presentation] DOCK1 as a novel target for controlling RAS-driven cancer cell survival and invasion.2018
- Author(s)
  Uruno T, Fukui Y
- Organizer
  An AACR Special Conference on "Targeting RAS-driven cancers"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02406
[Presentation] DOCK1 as a novel molecular target for controlling cancer cell survival and invasion.2018
- Author(s)
  Tatsuguchi T, Uruno T, Fukui Y
- Organizer
  The 25th Biennial Congress of the European Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02406
[Presentation] Immune regulatory functions of DOCK family proteins in health and diseases2017
- Author(s)
  Uruno T, Fukui Y
- Organizer
  Pfizer Science Day 2017「自己免疫・炎症疾患とNASHの革新的な医療ニーズを探る」
- Invited
- Data Source
  KAKENHI-PROJECT-16H02497
[Presentation] DOCK1 as a novel molecular target for controlling cancer invasion and metastasis2015
- Author(s)
  Tajiri H, Uruno T, Watanabe M, Maehara Y, Fukui Y.
- Organizer
  第26回日本消化器癌発生学会
- Place of Presentation
  鳥取
- Year and Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-26430115

1. Fukui Yoshinori (60243961)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
2. 田中芳彦 (00398083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. OHKAWA Yasuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 片貝智哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 柊元睦子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 渡辺武

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 馬場健史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 和泉自泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Uruno Takehito 宇留野 武人

URUNO Takehito 宇留野 武人

Research Projects

Research Products

Co-Researchers

腫瘍の免疫特権環境形成における硫酸化コレステロールの役割と創薬応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analyses for expression and function of the sulfotransferase SULT2B1b

Principal Investigator

Project Period (FY)

Research Category

Review Section

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Role of the Rac activator DOCK1 in immune evasion by tumorPrincipal Investigator

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Review Section

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Molecular basis for Jmjd6-mediated control of Aire protein expression and its evolutional insight

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Role of DOCK family proteins in malignant transformation by human oncogenic RacPrincipal Investigator

Principal Investigator

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Comprehensive analyses for biological functions and regulatory mechanisms of DOCK family proteins

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[Journal Article] Pharmacological intervention of cholesterol sulfate-mediated T cell exclusion promotes antitumor immunity2022

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[Journal Article] Cancer-derived cholesterol sulfate is a key mediator to prevent tumor infiltration by effector T cells2022

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[Journal Article] 2.論文標題 DOCK8 deficiency causes a skewing to type 2 immunity in the gut with expansion of group 2 innate lymphoid cells.2021

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[Journal Article] A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK82021

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[Journal Article] Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound.2021

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[Journal Article] DOCK8 controls survival of group 3 innate lymphoid cells in the gut through Cdc42 activation.2021

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NAID

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[Journal Article] Selective role of neurokinin B in IL-31-induced itch response in mice2019

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[Journal Article] S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer’s Patches2019

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Uruno Takehito 宇留野武人

URUNO Takehito 宇留野武人