Yamagata Kaoru 山形薫

… Alternative Names

YAMAGATA KAORU 山形薫

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Researcher Number	80533786
Affiliation (Current)	2025: 産業医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2025: 産業医科大学, 医学部, 講師 2021 – 2023: 産業医科大学, 医学部, 講師 2016 – 2020: 産業医科大学, 医学部, 助教 2013: 産業医科大学, 医学部, 助教 2012: 神戸大学, 医学(系)研究科(研究院), グローバルCOE研究員 … More 2011: 神戸大学, 大学院・医学研究科, グローバルCOE研究員 2009 – 2011: 神戸大学, 医学研究科, グローバルCOE研究員 2009: 神戸大学, 大学院・医学研究科, 助教 Less
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 56020:Orthopedics-related / Collagenous pathology/Allergology / Experimental pathology / Pathological medical chemistry Except Principal Investigator Biological Sciences
Keywords	Principal Investigator 関節リウマチ / スーパーエンハンサー / ChIP / 軟骨細胞 / 間葉系幹細胞 / lncRNA / B細胞 / CD20陽性B細胞 / plasmocyte / P2RY10 … More / ＣD20陽性B細胞 / 関節破壊 / 炎症 / MED1 / SNP / ubash3a / eRNA / BACH2 / UBASH3A / CD4陽性T細胞 / 免疫学 / 骨破壊 / 破骨細胞 / 14-3-3 eta / PADI4 / 関節液 / ネクロプトーシス / TNF-α / シトルリン化 / PAD4 / 14-3-3η / マクロファージ / 組織線維化 / メタボローム解析 / 基底膜破壊 / 腎線維化 / 腎不全 / ＭＭＰ－２ / ＵＵＯ / Ｒｏｒ２ / Ｗｎｔ５ａ / 遺伝子発現 / 骨肉腫 / 軟骨内骨化 / MMP-13 / AP1 / Dvl2 / Ror2 / Wnt5a … More Except Principal Investigator 悪性腫瘍 / WIP1ホスファターゼ / ATMキナーゼ / Chk1キナーゼ / DNA損傷 / がんの分子標的治療 / 核内シングル伝達 / がん遺伝子産物 / チェックポイントキナーゼ / チェツクポイント機構 / リン酸化・脱リン酸化 / チェックポイント機構 / がん抑制遺伝子産物 / がん原遺伝子産物 / 癌の浸潤 / 14-3-3 / 癌化 / がんの浸潤 / Ror2シグナル / Wnt5a / Wip1ホスファターゼ / Chk2キナーゼ / がん化 / シグナル伝達 / DNA損傷応答 Less

ヒト軟骨形成において長鎖非コードRNA(lncRNA)が担う革新的な軟骨形成基盤の解明Principal Investigator
- Principal Investigator
  
  山形薫
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  University of Occupational and Environmental Health, Japan
B細胞のスーパーエンハンサー異常を介した関節リウマチの新規病態形成基盤の解明Principal Investigator
- Principal Investigator
  
  山形薫
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  University of Occupational and Environmental Health, Japan
A novel pathogenesis of rheumatoid arthritis due to dysregulated super-enhancer in CD4-positive T cellsPrincipal Investigator
- Principal Investigator
  
  YAMAGATA KAORU
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  University of Occupational and Environmental Health, Japan
Critical role of 14-3-3 eta in pathogenesis of rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  YAMAGATA KAORU
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  University of Occupational and Environmental Health, Japan
Analysis of Wnt5a-Ror signaling in renal fibrosisPrincipal Investigator
- Principal Investigator
  
  YAMAGATA Kaoru
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Occupational and Environmental Health, Japan
  Kobe University
Molecular mechanism of cancer cells invasiveness regulated by Ror2 signaling in human osteosarcoma cellsPrincipal Investigator
- Principal Investigator
  
  YAMAGATA Kaoru
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University
Molecular mechanism of DNA damage-induced responses and its failure by carcinogenesis
- Principal Investigator
  
  MINAMI Yasuhiro
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University

[Book] 最新の骨粗鬆学（第２版）2023
- Author(s)
  山形薫、田中良哉
- Total Pages
  7
- Publisher
  日本臨牀
- Data Source
  KAKENHI-PROJECT-22K08536
[Book] 最新の骨粗鬆症学（第２版）2023
- Author(s)
  山形薫、田中良哉
- Total Pages
  7
- Publisher
  日本臨牀
- Data Source
  KAKENHI-PROJECT-22K08536
[Book] 最新関節リウマチ学（第２版）2022
- Author(s)
  山形薫、田中良哉
- Total Pages
  6
- Publisher
  日本臨牀
- Data Source
  KAKENHI-PROJECT-22K08536
[Book] 動物／疾患モデルの作製技術・病態解析・評価手法関節リウマチにおける最新メカニズム、創薬応用と動物評価試験。2017
- Author(s)
  山形薫、中山田真吾、田中良哉。
- Total Pages
  428
- Publisher
  技術情報協会
- ISBN
  9784861046650
- Data Source
  KAKENHI-PROJECT-16K09914
[Book] 動物／疾患モデルの作製技術・病態解析・評価手法：関節リウマチにおける動物モデルの作製手法。2017
- Author(s)
  山形薫、中山田真吾、張香梅、田中良哉。
- Total Pages
  428
- Publisher
  技術情報協会
- ISBN
  9784861046650
- Data Source
  KAKENHI-PROJECT-16K09914
[Journal Article] IL-6 production through repression of UBASH3A gene via epigenetic dysregulation of super-enhancer in CD4+ T cells in rheumatoid arthritis.2022
- Author(s)
  Yamagata K, Nakayamada S, Zhang T, Nguyen AP, Ohkubo N, Iwata S, Kato S, Tanaka Y.
- Journal Title
  
  Inflamm Regen
  
  Volume: 42 Issue: 1 Pages: 46-59
- DOI
  10.1186/s41232-022-00246-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08536
[Journal Article] TGF-β3 in differentiation and function of Tph-like cells and its relevance to disease activity in patients with systemic lupus erythematosus.2022
- Author(s)
  Shan Y, Nakayamada S, Nawata A, Yamagata K, Sonomoto K, Tanaka H, Satoh-Kanda Y, Nguyen MP, Todoroki Y, Nagayasu A, Ueno M, Kanda R, Fujita Y, Zhang T, Hao H, Zhou J, Ma X, Anan J, Nguyen AP, Tanaka Y.
- Journal Title
  
  Rheumatology (Oxford).
  
  Volume: keac646. Issue: 7 Pages: 2464-2474
- DOI
  10.1093/rheumatology/keac646
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08536, KAKENHI-PROJECT-20K08815
[Journal Article] pstein-Barr virus-induced gene 3 commits human mesenchymal stem cells to differentiate into chondrocytes via endoplasmic reticulum stress sensor.2022
- Author(s)
  Zhang T, Yamagata K, Iwata S, Sonomoto K, Trimova G, Nguyen AP, Hao H, Shan Y, Nguyen MP, Nakayamada S, Tanaka Y.
- Journal Title
  
  PLoS One
  
  Volume: 17 Issue: 12 Pages: e0279584-e0279584
- DOI
  10.1371/journal.pone.0279584
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08536
[Journal Article] Role of DNA dioxygenase Ten-Eleven translocation 3 (TET3) in rheumatoid arthritis progression.2022
- Author(s)
  Kawabe A, Yamagata K, Kato S, Nakano K, Sakata K, Tsukada YI, Ohmura K, Nakayamada S, Tanaka Y.
- Journal Title
  
  Arthritis Research Therapy
  
  Volume: 24 Issue: 1 Pages: 222-222
- DOI
  10.1186/s13075-022-02908-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08534, KAKENHI-PROJECT-22K08536
[Journal Article] Enhancer RNA commits osteogenesis via microRNA-3129 expression in human bone marrow-derived mesenchymal stem cells.2022
- Author(s)
  Nguyen AP, Yamagata K, Iwata S, Trimova G, Zhang T, Shan Y, Nguyen MP, Sonomoto K, Nakayamada S, Kato S, Tanaka Y.
- Journal Title
  
  Inflamm Regen
  
  Volume: 42 Issue: 1 Pages: 43-54
- DOI
  10.1186/s41232-022-00228-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08536
[Journal Article] T helper cells expressing fractalkine receptor and bearing T follicular helper 1-like cell functions in patients with IgG4-related disease.2021
- Author(s)
  Inoue Y, Nakayamada S, Kubo S, Yamagata K, Sonomoto K, Iwata S, Miyazaki Y, Tanaka Y.
- Journal Title
  
  Rheumatology (Oxford)
  
  Volume: 未定 Issue: 9 Pages: 3854-3863
- DOI
  10.1093/rheumatology/keab935
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08925, KAKENHI-PROJECT-22K08536
[Journal Article] Human dendritic cell-derived osteoclasts with high bone resorption capacity and T cell stimulation ability.2021
- Author(s)
  Narisawa M, Kubo S, Okada Y, Yamagata K, Nakayamada S, Sakata K, Yamaoka K, Tanaka Y.
- Journal Title
  
  Bone.
  
  Volume: 142 Pages: 115616-115616
- DOI
  10.1016/j.bone.2020.115616
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08925, KAKENHI-PROJECT-18K16164
[Journal Article] Involvement of lncRNA IL21-AS1 in interleukin-2 and T follicular regulatory cell activation in systemic lupus erythematosus.2021
- Author(s)
  Hao H, Nakayamada S, Ohkubo N, Yamagata K, Zhang M, Shan Y, Iwata S, Zhang T, Tanaka Y.
- Journal Title
  
  Arthritis Res Ther.
  
  Volume: 23 Issue: 1 Pages: 302-312
- DOI
  10.1186/s13075-021-02682-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08925, KAKENHI-PROJECT-20K08815
[Journal Article] IL-2 drives conversion of T follicular helper cells to T follicular regulatory cells through transcriptional regulation in systemic lupus erythematosus.2021
- Author(s)
  Hao H, Nakayamada S, Yamagata K, Ohkubo N, Iwata S, Inoue Y, Zhang M, Zhang T, Kanda Satoh Y, Shan Y, Otsuka T, Tanaka Y.
- Journal Title
  
  Arthritis Rheumatol.
  
  Volume: 73 Issue: 1 Pages: 132-142
- DOI
  10.1002/art.41457
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08925, KAKENHI-PROJECT-20K08815
[Journal Article] Critical Roles of Super-enhancers in the Pathogenesis of Autoimmune Diseases.2020
- Author(s)
  Yamagata K, Nakayamada S, Tanaka Y.
- Journal Title
  
  Inflamm Regen.
  
  Volume: 40 Issue: 1 Pages: 16-16
- DOI
  10.1186/s41232-020-00124-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08925
[Journal Article] IL-23 drives expansion of Th17 cells through epigenetic regulation by signal transducer and activators of transcription 3 in lupus patients.2020
- Author(s)
  Lee S, Nakayamada S, Kubo S, Yamagata K, Yoshinari H, Tanaka Yoshiya.
- Journal Title
  
  Rheumatology (Oxford).
  
  Volume: 59 Issue: 10 Pages: 3058-3069
- DOI
  10.1093/rheumatology/keaa176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08925
[Journal Article] Methionine commits cells to differentiate into plasmablasts through epigenetic regulation of BTB and CNC homolog 2 by the methyltransferase enhancer of zeste homolog 2.2020
- Author(s)
  Zhang M, Iwata S, Hajime M, Ohkubo N, Todoroki Y, Miyata H, Ueno M, Hao H, Zhang T, Fan J, Nakayamada S, Yamagata K, Tanaka Y.
- Journal Title
  
  Arthritis Rheumatol.
  
  Volume: － Issue: 7 Pages: 1143-1153
- DOI
  10.1002/art.41208
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08900, KAKENHI-PROJECT-19K08925
[Journal Article] Tumour necrosis factor alpha promotes secretion of 14-3-3η by inducing necroptosis in macrophages2020
- Author(s)
  Trimova G, Yamagata K, Iwata S, Hirata S, Zhang T, Uemura F, Satoh M, Biln N, Nakayamada S, Maksymowych WP, Tanaka Y
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 22 Issue: 1 Pages: 24-24
- DOI
  10.1186/s13075-020-2110-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07940, KAKENHI-PROJECT-19K08925, KAKENHI-PROJECT-19K08617
[Journal Article] Soluble IL-6R promotes chondrogenic differentiation of mesenchymal stem cells to enhance the repair of articular cartilage defects using a rat model for rheumatoid arthritis.2019
- Author(s)
  Yamagata K, Nakayamada S, Zhang T, Zhang X, Tanaka Y.
- Journal Title
  
  Clin Exp Rheumatol.
  
  Volume: －
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08925
[Journal Article] Glycolaldehyde-modified advanced glycation end-products inhibit differentiation of human monocytes into osteoclasts via upregulation of IL-10.2019
- Author(s)
  Tanaka K, Yamagata K, Kubo S, Nakayamada S, Sakata K, Matsui T, Yamagishi SI, Okada Y, Tanaka Y.
- Journal Title
  
  Bone
  
  Volume: 128 Pages: 115034-115034
- DOI
  10.1016/j.bone.2019.115034
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08925, KAKENHI-PROJECT-19K17995
[Journal Article] IL-6 and sIL-6R induces STAT3-dependent differentiation of human VSMCs into osteoblast-like cells through JMJD2B-mediated histone demethylation of RUNX2.2019
- Author(s)
  Kurozumi A, Nakano K, Yamagata K, Okada Y, Nakayamada S, Tanaka Y.
- Journal Title
  
  Bone
  
  Volume: 124 Pages: 53-61
- DOI
  10.1016/j.bone.2019.04.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08925
[Journal Article] Relevance of interferon-gamma in pathogenesis of life-threatening rapidly progressive interstitial lung disease in patients with dermatomyositis.2018
- Author(s)
  Ishikawa Y, Iwata S, Hanami K, Nawata A, Zhang M, Yamagata K, Hirata S, Sakata K, Todoroki Y, Nakano K, Nakayamada S, Satoh M, Tanaka Y.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 20 Issue: 1 Pages: 240-240
- DOI
  10.1186/s13075-018-1737-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09914, KAKENHI-PROJECT-16K09915
[Journal Article] Expansion of T follicular helper-T helper 1 like cells through epigenetic regulation by signal transducer and activator of transcription factors2018
- Author(s)
  Ma X, Nakayamada S, Kubo S, Sakata K, Yamagata K, Miyazaki Y, Yoshikawa M, Kitanaga Y, Zhang M, Tanaka Y.
- Journal Title
  
  Annals of Rheumatic Diseases
  
  Volume: 88 Issue: 9 Pages: 1354-1361
- DOI
  10.1136/annrheumdis-2017-212652
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10010, KAKENHI-PROJECT-16K09914
[Journal Article] Use of mesenchymal stem cells seeded on the scaffold in articular cartilage repair.2018
- Author(s)
  Yamagata K, Nakayamada S, Tanaka Y.
- Journal Title
  
  Inflamm Regen
  
  Volume: 38 Issue: 1 Pages: 4-4
- DOI
  10.1186/s41232-018-0061-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09914
[Journal Article] Janus Kinase Inhibitor Baricitinib Modulates Human Innate and Adaptive Immune System.2018
- Author(s)
  Kubo S, Nakayamada S, Sakata K, Kitanaga Y, Ma X, Lee S, Ishii A, Yamagata K, Nakano K, Tanaka Y.
- Journal Title
  
  Front Immunol
  
  Volume: 9 Pages: 1510-1510
- DOI
  10.3389/fimmu.2018.01510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09914
[Journal Article] Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells.2017
- Author(s)
  Miyagawa I, Nakayamada S, Nakano K, Yamagata K, Sakata K, Yamaoka K, Tanaka Y.
- Journal Title
  
  J Immunol
  
  Volume: 199 Issue: 5 Pages: 1616-1625
- DOI
  10.4049/jimmunol.1600230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09914
[Journal Article] Spontaneous differentiation of human mesenchymal stem cells on poly-lactic-co-glycolic acid nano-fiber scaffold2016
- Author(s)
  Koshiro Sonomoto, Kunihiro Yamaoka, Hiroaki Kaneko, Kaoru Yamagata, Kei Sakata, Xiangmei Zhang, Masahiro Kondo, Yukichi Zenke, Ken Sabanai, Shingo Nakayamada, Akinori Sakai, Yoshiya Tanaka
- Journal Title
  
  PLOS ONE
  
  Volume: in press Issue: 4 Pages: e0153231-e0153231
- DOI
  10.1371/journal.pone.0153231
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860821, KAKENHI-PROJECT-15K10499, KAKENHI-PROJECT-16K09914
[Journal Article] The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells.2014
- Author(s)
  Kubo S, Yamaoka K, Kondo M, Yamagata K, Zhao J, Iwata S, Tanaka Y.
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 未定 Issue: 12 Pages: 2192-2198
- DOI
  10.1136/annrheumdis-2013-203756
- NAID
  110010039749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790385
[Journal Article] Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition (EMT) of tubular epithelial cells during renal fibrosis2013
- Author(s)
  K. Yamagata, X. Li, M. Nishita, M. Endo, N. Arfian, Y. Rikitake, N. Emoto, K-I. Hirata, Y. Tanaka, Minami Y
- Journal Title
  
  Genes Cells
  
  Volume: 18 Pages: 608-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790385
[Journal Article] Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition (EMT) of tubular epithelial cells during renal fibrosis.2013
- Author(s)
  Li, X., Yamagata, K., Nishita, M., Endo, M., Arfian, N., Rikitake, Y., Emoto, N., Hirata, K., Tanaka, Y., Minami, Y.
- Journal Title
  
  Genes Cells
  
  Volume: 18 Issue: 7 Pages: 608-619
- DOI
  10.1111/gtc.12064
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23112007, KAKENHI-PROJECT-23590123, KAKENHI-PROJECT-24390080, KAKENHI-PROJECT-24790385
[Journal Article] Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase(MMP)-13 expression2012
- Author(s)
  K. Yamagata, X. Li, S. Ikegaki, C. Oneyama, M. Okada, M. Nishita, Y. Minami.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 287(2) Pages: 1588-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790315
[Journal Article] Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase(MMP-13) expression2012
- Author(s)
  Yamagata K, Li X, Ikegaki S, Oneyama C, Okada M, Nishita M, Minami Y
- Journal Title
  
  J Biol Chem
  
  Volume: 287(2) Issue: 2 Pages: 1588-99
- DOI
  10.1074/jbc.m111.315127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689009, KAKENHI-PROJECT-22790291, KAKENHI-PROJECT-22790315, KAKENHI-PLANNED-23112008, KAKENHI-PROJECT-23650595
[Journal Article] Cell/tissue-tropic functions of Wnt5a signaling in normal and cancer cells2010
- Author(s)
  西田満、榎本真宏、山形薫、南康博
- Journal Title
  
  Trends in Cell Biology
  
  Volume: 20 Pages: 346-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790315
[Journal Article] Cell/tissue-tropic functions of Wnt5a signaling in normal and cancer cells2010
- Author(s)
  Nishita, M., Enomoto, M., Yamagata, K., Minami, Y.
- Journal Title
  
  Trends in Cell Biol 20
  
  Pages: 346-354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014062
[Journal Article] Maturation of micro RNA is hormonally regulated by a nuclear receptor.2009
- Author(s)
  Yamagata, K., et al.
- Journal Title
  
  Mol.Cell 36
  
  Pages: 340-347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014062
[Journal Article] The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells
- Author(s)
  S. Kubo, K. Yamaoka, M. Kondo, K. Yamagata, J. Zhao, S. Iwata, Y. Tanaka
- Journal Title
  
  Ann. Rheum. Dis
  
  Volume: (in press)
- NAID
  110010039749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790385
[Patent] 軟骨組織修復方法2019
- Inventor(s)
  田中良哉、山形薫、中山田真吾
- Industrial Property Rights Holder
  田中良哉、山形薫、中山田真吾
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-119273
- Filing Date
  2019
- Acquisition Date
  2020
- Data Source
  KAKENHI-PROJECT-19K08925
[Patent] 軟骨組織修復方法2016
- Inventor(s)
  田中良哉、中山田真吾、山形薫
- Industrial Property Rights Holder
  田中良哉、中山田真吾、山形薫
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-119273
- Filing Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16K09914
[Presentation] MicroRNA-3129がもたらすヒト骨髄由来間葉系幹細胞の骨形成におけるスーパーエンハンサーの機能的役割2023
- Author(s)
  山形薫, Nguyen Phuong Anh, 中山田真吾, 加藤茂明, 田中良哉
- Organizer
  第41回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08536
[Presentation] ナノファイバーを用いた最適化間葉系幹細胞のラット生体内移植による関節軟骨の修復2023
- Author(s)
  山形薫、中山田真吾、近藤真弘、田中良哉
- Organizer
  第41回日本骨代謝学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08536
[Presentation] ヒト樹状細胞由来破骨細胞におけるサイトカイン遺伝子の発現様式とJAK阻害薬の作用2023
- Author(s)
  山形薫、中山田真吾、神田龍一郎、田中良哉
- Organizer
  第67回日本リウマチ学会総会・学術総会
- Data Source
  KAKENHI-PROJECT-22K08536
[Presentation] MicroRNA-3129が担うヒト骨髄由来間葉系幹細胞の骨形成におけるスーパーエンハンサーの機能的役割2023
- Author(s)
  山形薫、Nguyen Phuong Anh、中山田真吾、加藤茂明、田中良哉
- Organizer
  第8回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-22K08536
[Presentation] IL-6シグナルの活性化によりヒト脂肪組織由来間葉系幹細胞は遅筋型筋芽細胞へ効率的に分化する2023
- Author(s)
  山形　薫、大塚　隆史、岡田　洋右、中山田　真吾、田中　良哉
- Organizer
  第8回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-22K08536
[Presentation] ヒト間葉系幹細胞の軟骨分化における細胞内Epstein-Barr virus-induced gene 3の重要な役割2023
- Author(s)
  山形薫、張童、中山田真吾、田中良哉
- Organizer
  第8回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-22K08536
[Presentation] IL-6シグナルはヒト脂肪組織由来間葉系幹細胞から骨格筋系譜細胞への分化を促進する2022
- Author(s)
  山形薫、大塚隆史、岡田洋右、中山田真吾、田中良哉
- Organizer
  第７回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-22K08536
[Presentation] 高い骨吸収能とT細胞刺激能を備えたヒト樹状細胞由来破骨細胞2022
- Author(s)
  山形　薫, 中山田　真吾, 成澤　学, 久保　智史, 岡田　洋右, 山岡　邦宏, 田中　良哉
- Organizer
  第７回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-22K08536
[Presentation] 高い骨吸収能とT細胞刺激能を有するヒト樹状細胞由来破骨細胞2022
- Author(s)
  山形　薫, 中山田　真吾, 成澤　学, 久保　智史, 岡田　洋右, 田中　良哉
- Organizer
  第8回骨免疫フォーラム
- Data Source
  KAKENHI-PROJECT-22K08536
[Presentation] IL-6 production through repression of UBASH3A gene via epigenetic dysregulation of super-enhancer in CD4+ T cells in rheumatoid arthritis2022
- Author(s)
  山形薫, 中山田真吾, 張童, 加藤茂明, 田中良哉
- Organizer
  第40回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08536
[Presentation] 関節リウマチ患者のCD4陽性T細胞におけるubash3a遺伝子のエピジェネティック制御と炎症誘導機構の解明2020
- Author(s)
  山形薫、中山田真吾、上村芙美、岩田慈、田中良哉
- Organizer
  第41回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-19K08925
[Presentation] Emerging role of epigenetic dysregulation of ubash3a in the pathogenesis of rheumatoid arthritis (RA)2020
- Author(s)
  Kaoru Yamagata, Shingo Nakayamada, Tong Zhang, Gulzhan Trimova, Phuong Anh Nguyen, Fumi Uemura, Ippei Miyagawa, Shigeru Iwata, Yoshiya Tanaka
- Organizer
  第64回日本リウマチ学会
- Data Source
  KAKENHI-PROJECT-19K08925
[Presentation] スーパーエンハンサー(SE)による関節リウマチ(RA)感受性遺伝子UBASH3A のエピジェネティック制御機構の解明2019
- Author(s)
  山形薫、中山田真吾、岩田慈、張童、トリモバグルズハン、グエンファンアン、上村芙美、宮川一平、加藤茂明、田中良哉
- Organizer
  第5回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-19K08925
[Presentation] スーパーエンハンサーによる UBASH3A 遺伝子のエピジェネティック制御とその破綻による関節リウマチ (RA)病態形成2019
- Author(s)
  山形薫、中山田真吾、岩田慈、Nguyen Phuong Anh、上村芙美、張童、Gulzhan Trimova、吉成紘子、宮川一平、加藤茂明、田中良哉
- Organizer
  第40回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-19K08925
[Presentation] Massive in silico studies specified UBASH3A as a candidate pathogenic factor that is down-regulated in CD4+T cells of patients with rheumatoid arthritis (RA)2019
- Author(s)
  Kaoru Yamagata, Shingo Nakayamada, Ippei Miyagawa, Fumi Uemura, Shigeru Iwata, Yoshiya Tanaka
- Organizer
  第63回日本リウマチ　学会
- Data Source
  KAKENHI-PROJECT-19K08925
[Presentation] ナノファイバーを用いた間葉系幹細胞生体内移植の最適化とEBI3による制御2019
- Author(s)
  山形薫、中山田真吾、張童、近藤真弘、岩田慈、田中良哉
- Organizer
  第37回日本骨代謝学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08925
[Presentation] TNF-ALPHA INDUCES NECROPTOSIS-LIKE DEATH OF MACROPHAGES AND PROMOTES EXTRACELLULAR RELEASE OF 14-3-3ETA2019
- Author(s)
  Gulzhan Trimova, Kaoru Yamagata, Shigeru Iwata, Tony Zhang, Fumi Uemura, Minoru Satoh, Michelle Zaharik, Norma Biln, Shintaro Hirata, Shingo Nakayamada, Yoshiya Tanaka
- Organizer
  Annual European Congress of Rheumatology EULAR 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09914
[Presentation] Massive in silico studies identified UBASH3A as potential pathogenic factor that is dysregulated in CD4+ T cells of patients with rheumatoid arthritis2018
- Author(s)
  Kaoru Yamagata、Shingo Nakayamada、Ippei Miyagawa、Fumi Uemura、Sigeru Iwata、Shigeaki Kato、Yoshiya Tanaka
- Organizer
  第47回日本免疫学会
- Data Source
  KAKENHI-PROJECT-16K09914
[Presentation] Efficient regeneration of cartilaginous tissue after application of IL-6R-stimulated mesenchymal stem cells with a novel delivering scaffold for the treatment of RA2018
- Author(s)
  Kaoru Yamagata, Shingo Nakayamada, Yoshiya Tanaka
- Organizer
  第62回　日本リウマチ学会
- Data Source
  KAKENHI-PROJECT-16K09914
[Presentation] IL-6受容体は間葉系幹細胞軟骨細胞分化を促進し、損傷関節軟骨の修復をもたらす2018
- Author(s)
  山形　薫、中山田　真吾、張　童、田中　良哉
- Organizer
  第39回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-16K09914
[Presentation] IL-6受容体はヒト間葉系幹細胞軟骨細胞分化を促進し、欠損関節軟骨の修復をもたらす2018
- Author(s)
  山形薫、中山田　真吾、張童、田中良哉
- Organizer
  第3回 United Front against Rheumatism
- Data Source
  KAKENHI-PROJECT-16K09914
[Presentation] 可溶性IL-6受容体は間葉系幹細胞軟骨細胞分化を促進し、欠損関節軟骨の修復をもたらす2018
- Author(s)
  山形　薫、中山田　真吾、張　童、田中　良哉
- Organizer
  第36回日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-16K09914
[Presentation] CD4陽性T細胞特異的に高発現するT細胞受容体（TCR）シグナル抑制因子UBASH3Aは関節リウマチ (RA)において発現が低下する2018
- Author(s)
  山形薫、中山田真吾、宮川一平、上村芙美、岩田慈、加藤茂明、田中良哉
- Organizer
  第4回　日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-16K09914
[Presentation] Regeneration of cartilage tissue after application of IL-6R-treated mesenchymal stem cells with a novel delivering scaffold for the treatment of RA2017
- Author(s)
  Kaoru Yamagata, Shingo Nakayamada, Yoshiya Tanaka
- Organizer
  EAGOR2017
- Data Source
  KAKENHI-PROJECT-16K09914
[Presentation] Efficient regeneration of cartilaginous tissue after application of IL-6R-stimulated mesenchymal stem cells with a novel delivering scaffold for the treatment of RA2017
- Author(s)
  Kaoru Yamagata, Shingo Nakayamada, Yoshiya Tanaka.
- Organizer
  第61回日本リウマチ学会
- Data Source
  KAKENHI-PROJECT-16K09914
[Presentation] IL-6受容体刺激間葉系幹細胞と乳酸グリコール酸共重合体の共移植による関節リウマチの軟骨破壊の修復と再生2017
- Author(s)
  山形　薫、中山田　真吾、近藤　真弘、田中　良哉
- Organizer
  第35回日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-16K09914
[Presentation] RA軟骨破壊の機序とその克服2017
- Author(s)
  山形薫, 中山田真吾, 近藤真弘, 中野和久, 田中良哉
- Organizer
  第61回日本リウマチ学会
- Data Source
  KAKENHI-PROJECT-16K09914
[Presentation] バイオマテリアルとIL-6受容体刺激間葉系幹細胞の共移植による関節リウマチの軟骨組織修復・再生の可能性2017
- Author(s)
  山形　薫、中山田　真吾、田中　良哉
- Organizer
  第3回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-16K09914
[Presentation] IL-6受容体刺激間葉系幹細胞とバイオマテリアルの共移植による関節リウマチモデル動物の軟骨組織破壊の再生2017
- Author(s)
  山形　薫、中山田　真吾、近藤　真弘、田中　良哉
- Organizer
  第38回日本炎症再生医学会
- Data Source
  KAKENHI-PROJECT-16K09914
[Presentation] Analysis of Wnt5a-Ror signaling in renal fibrosis using a mouse model2012
- Author(s)
  Yamagata K, Li X, Nur A, Endo M, Rikitake Y, Emoto N, Nishita M, Minami Y
- Organizer
  The 3rd GCOE International Symposium on Signal Transduction Medicine in the Coming Generation
- Place of Presentation
  神戸
- Year and Date
  2012-12-10
- Data Source
  KAKENHI-PROJECT-24790385
[Presentation] Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase(MMP)-13 expression2011
- Author(s)
  山形薫、池垣俊吉、李欣、南康博
- Organizer
  Joint Symposium on Integrative Membrane Biology and Signal Transduction Medicine
- Place of Presentation
  University of Washington-Kobe University神戸
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22790315
[Presentation] Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression2011
- Author(s)
  山形薫、池垣俊吉、李欣、南康博
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜会場
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22790315
[Presentation] がんの進展におけるWnt5a-Rorシグナルの機能解析2011
- Author(s)
  山形薫、南康博
- Organizer
  第3回シグナルネットワーク研究会
- Place of Presentation
  東京
- Year and Date
  2011-05-27
- Data Source
  KAKENHI-PROJECT-22790315
[Presentation] Molecular analysis of MMP13 gene expression by Wnt5a-Ror2 signaling in human osteosarcoma cells2011
- Author(s)
  山形薫、池垣俊吉、李欣、南康博
- Organizer
  第3回次世代シグナル伝達医学グローバルCOE研究討論会
- Place of Presentation
  淡路
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-22790315
[Presentation] Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase(MMP)-13 expression2011
- Author(s)
  山形薫、池垣俊吉、李欣、南康博
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22790315
[Presentation] Analysis of MMP13 gene expression induced by Wnt5a-Ror2 signaling in human osteosarcoma cell line2010
- Author(s)
  山形薫、李欣、渡邊康秀、南康博
- Organizer
  第2回次世代シグナル伝達医学グローバルCOE研究討論会
- Place of Presentation
  淡路
- Year and Date
  2010-07-05
- Data Source
  KAKENHI-PROJECT-22790315
[Presentation] Wnt5a-Ror2シグナルによる細胞極性・移動制御とがんの浸潤2010
- Author(s)
  南康博、山形薫、西田満
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  大阪
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-22790315
[Presentation] Wnt5a-Ror2シグナルによる細胞極性・移動制御とがんの浸潤2010
- Author(s)
  南康博、山形薫、西田満
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  大阪国際会議場(大阪府)(招待講演)
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-22790315

1. 田中良哉 (30248562)

# of Collaborated Projects: 4 results

# of Collaborated Products: 52 results
2. MINAMI Yasuhiro (70229772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. YODA AKINORI (70335454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NISHITA MICHIRU (30379359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. ENDO MITSUHARU (90436444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Trimova Gluzhan

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. NAKANO Kazuhisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. HIRATA Shintaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 中山田真吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 小根山千歳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 岩田慈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 園本格士朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamagata Kaoru 山形 薫

YAMAGATA KAORU 山形 薫

Research Projects

Research Products

Co-Researchers

ヒト軟骨形成において長鎖非コードRNA(lncRNA)が担う革新的な軟骨形成基盤の解明Principal Investigator

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B細胞のスーパーエンハンサー異常を介した関節リウマチの新規病態形成基盤の解明Principal Investigator

Principal Investigator

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A novel pathogenesis of rheumatoid arthritis due to dysregulated super-enhancer in CD4-positive T cellsPrincipal Investigator

Principal Investigator

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Critical role of 14-3-3 eta in pathogenesis of rheumatoid arthritisPrincipal Investigator

Principal Investigator

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Analysis of Wnt5a-Ror signaling in renal fibrosisPrincipal Investigator

Principal Investigator

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Molecular mechanism of cancer cells invasiveness regulated by Ror2 signaling in human osteosarcoma cellsPrincipal Investigator

Principal Investigator

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Molecular mechanism of DNA damage-induced responses and its failure by carcinogenesis

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[Book] 最新の骨粗鬆学（第２版）2023

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[Book] 最新の骨粗鬆症学（第２版）2023

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[Book] 最新関節リウマチ学（第２版）2022

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[Book] 動物／疾患モデルの作製技術・病態解析・評価手法関節リウマチにおける最新メカニズム、創薬応用と動物評価試験。2017

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[Book] 動物／疾患モデルの作製技術・病態解析・評価手法：関節リウマチにおける動物モデルの作製手法。2017

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[Journal Article] IL-6 production through repression of UBASH3A gene via epigenetic dysregulation of super-enhancer in CD4+ T cells in rheumatoid arthritis.2022

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[Journal Article] TGF-β3 in differentiation and function of Tph-like cells and its relevance to disease activity in patients with systemic lupus erythematosus.2022

Yamagata Kaoru 山形薫

YAMAGATA KAORU 山形薫