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AOKI YOSHITSUGU  青木 吉嗣

Researcher Number 80534172
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-9038-7506
Affiliation (Current) 2025: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 遺伝子疾患治療研究部, 部長
Affiliation (based on the past Project Information) *help 2019 – 2025: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 遺伝子疾患治療研究部, 部長
2018: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 遺伝子疾患治療研究部, 室長
2017: 国立研究開発法人国立精神・神経医療研究センター, その他部局等, 研究員(移行)
2015 – 2016: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 遺伝子疾患治療研究部, 室長
2015: 国立研究開発法人国立精神・神経医療研究センター, その他部局等, その他
Review Section/Research Field
Principal Investigator
Basic Section 52020:Neurology-related / Basic Section 52020:Neurology-related / Experimental pathology
Except Principal Investigator
Basic Section 59040:Nutrition science and health science-related / Basic Section 42040:Laboratory animal science-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Basic Section 47040:Pharmacology-related / Experimental pathology / Sports science
Keywords
Principal Investigator
筋ジストロフィー / デュシェンヌ型筋ジストロフィー / エクソン・スキップ / マルチオミクス / LPCAT / アシル転移酵素 / リゾリン脂質 / リピドミクス解析 / MyoD / 尿由来細胞 … More / ヒト尿由来細胞 / 疾患モデルマウス / マルチオミクス解析 / 加齢性筋萎縮 / Duchenne型筋ジスト ロフィー / RNA編集 / 神経内科 / 老化 / プロテオミクス / プロテオミクス解析 / マウス / インタラクトミクス / 定量質量分析 / 骨格筋 / 加齢 / 超高感度定量質量分析 / 速筋型タイプII筋線維 / 筋萎縮 / サルコペニア / 筋収縮 / SR-A欠損マウス / ペプチド付加モルフォリノ核酸 / モルフォリノ核酸 / クラスA スカベンジャー受容体 / 薬物送達 / ジストロフィン / 薬物送達システム / エクソン 53 スキップ / スカベンジャー受容体 / モルフォリノ / アンチセンス核酸 … More
Except Principal Investigator
デュシェンヌ型筋ジストロフィー / ベッカー型筋ジストロフィー / Duchenne型筋ジストロフィー / 筋萎縮 / 脂質代謝 / サルコペニア / 筋疾患 / 骨格筋 / 幹細胞移植 / Muse細胞 / 間質液 / 生体恒常性維持 / 運動模倣介入 / メカニカルストレス / RNA修復 / RNA editing / ADAR1 / 脱アミン化 / 人為的RNA編集 / アミノ基転移 / 脱アミノ化 / 疾患治療 / アミノ転移酵素 / 脱アミノ化酵素 / PPRタンパク質 / MS2システム / DYW相同体 / DYWドメイン相同体 / PPR56 / DRHドメイン / GRPドメイン / DYWドメイン / ツノゴケ / デアミナーゼ / 遺伝コード修復 / RNA編集 / エクソンスキップ治療 / アンチセンス核酸 / iPS細胞 / ゲノム編集 / アンチセンス薬 / エクソン・スキップ治療 / DMD遺伝子 / SERCA / 細胞内Ca2+動態 / 筋ジストロフィー / ニトロシル化 / 細胞内Ca2+ / リアノジン受容体 / サルコリピン / SERCA / 筋小胞体 / IP3R / P2Y / ATP / NO / nNOS / カルシウム / 筋肥大 Less
  • Research Projects

    (11 results)
  • Research Products

    (91 results)
  • Co-Researchers

    (35 People)
  •  Development for the treatment of muscle atrophy through the regulation of muscle metabolism

    • Principal Investigator
      本橋 紀夫
    • Project Period (FY)
      2025 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      National Center of Neurology and Psychiatry
  •  力学の理解に基づく代謝異常症及び認知機能障害に対する革新的治療法開発の基盤構築

    • Principal Investigator
      澤田 泰宏
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
    • Research Institution
      National Rehabilitation Center for Persons with Disabilities
  •  Basic research on Muse cell transplantation for Duchenne muscular dystrophy

    • Principal Investigator
      富成 司
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 42040:Laboratory animal science-related
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Full-length dystrophin restoration by in vivo RNA editing via a minidCas13X.1 conjugated ADARPrincipal Investigator

    • Principal Investigator
      青木 吉嗣
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for JSPS Fellows
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Research of Genetic Code Restoration Therapy-Restoration of Mutated RNAs by Artificial RNA Editing

    • Principal Investigator
      Tsukahara Toshifumi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
    • Research Institution
      Japan Advanced Institute of Science and Technology
  •  Multi-omics technologies to reveal common mechanism of dystrophic and sarcopenic skeletal musclesPrincipal Investigator

    • Principal Investigator
      青木 吉嗣
    • Project Period (FY)
      2021 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Age-related and mutation-independent proteomic changes in dystrophic mouse musclePrincipal Investigator

    • Principal Investigator
      Aoki Yoshitsugu
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Development of DMD exon 3-9 skipping therapy using iPSc

    • Principal Investigator
      Nakamura Akinori
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47040:Pharmacology-related
    • Research Institution
      Shinshu University
  •  Truncated dystrophin ameliorates the dystrophic phenotype of mdx mice by reducing sarcolipin-mediated SERCA inhibition.

    • Principal Investigator
      Tanihata Jun
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Jikei University School of Medicine
      National Center of Neurology and Psychiatry
  •  Scavenger receptor-mediated uptake of antisense oligonucleotides into muscle cellsPrincipal Investigator

    • Principal Investigator
      AOKI YOSHITSUGU
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Experimental pathology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Elucidation of the mechanisms of skeletal muscle hypertrophy by intracellular calcium concentration.

    • Principal Investigator
      TAKEDA SHIN'ICHI
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Sports science
    • Research Institution
      National Center of Neurology and Psychiatry

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation Book Patent

  • [Book] CLINICAL NEUROSCIENCE2020

    • Author(s)
      青木吉嗣
    • Total Pages
      6
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Book] MD Frontier 筋ジストロフィー診療の今を考える2020

    • Author(s)
      青木吉嗣
    • Total Pages
      8
    • Publisher
      メディカルレビュー社
    • ISBN
      9784779225598
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Book] ダイレクトリプログラミング ~ 再生医療の新展開 ~2020

    • Author(s)
      青木吉嗣
    • Total Pages
      8
    • Publisher
      エヌ・ティー・エス
    • ISBN
      9784860436711
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Book] 実験医学2020年10月号2020

    • Author(s)
      青木吉嗣
    • Total Pages
      8
    • Publisher
      羊土社
    • ISBN
      9784758125369
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Book] アンチセンス医薬開発の最前線(2)神経・筋疾患に対するアンチセンス医薬品2019

    • Author(s)
      青木吉嗣
    • Total Pages
      6
    • Publisher
      医薬品医療機器レギュラトリーサイエンス財団
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Book] PrecisionMedicine2019

    • Author(s)
      青木吉嗣
    • Total Pages
      6
    • Publisher
      北隆館
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Book] PHARM TECH JAPAN2019

    • Author(s)
      青木吉嗣
    • Total Pages
      6
    • Publisher
      じほう
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Book] 週刊医学のあゆみ2016

    • Author(s)
      青木吉嗣
    • Total Pages
      6
    • Publisher
      医歯薬出版株式会社
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Book] 実験医学2016

    • Author(s)
      宮武正太,青木吉嗣
    • Total Pages
      8
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Book] Duchenne型筋ジストロフィーに対するエクソンスキップ薬開発の試み2016

    • Author(s)
      青木吉嗣
    • Total Pages
      4
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Book] EBMに基づく脳神経疾患の基本治療指針 第4版2016

    • Author(s)
      青木吉嗣
    • Total Pages
      7
    • Publisher
      株式会社メディカルビュー社
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Book] 筋収縮機構と遺伝性筋疾患2015

    • Author(s)
      青木吉嗣
    • Total Pages
      6
    • Publisher
      日本臨床社
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Journal Article] Characterization of CD90/Thy-1 as a crucial molecular signature for myogenic differentiation in human urine-derived cells through single-cell RNA sequencing2024

    • Author(s)
      Kunitake Katsuhiko、Motohashi Norio、Inoue Takafumi、Suzuki Yutaka、Aoki Yoshitsugu
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1 Pages: 2329-2329

    • DOI

      10.1038/s41598-024-52530-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K11615, KAKENHI-PROJECT-23K21412
  • [Journal Article] Establishment of a Triple Quadrupole HPLC-MS Quantitation Method for Dystrophin Protein in Mouse and Human Skeletal Muscle.2023

    • Author(s)
      Tominari T, Takatoya M, Matsubara T, Matsunobe M, Arai D, Matsumoto C, Hirata M, Yoshinouchi S, Miyaura C, Itoh Y, Komaki H, Takeda S, Aoki Y, Inada M.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 25 Issue: 1 Pages: 303-303

    • DOI

      10.3390/ijms25010303

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K05490, KAKENHI-PROJECT-23K05627, KAKENHI-PROJECT-20H00574, KAKENHI-PROJECT-23K21412, KAKENHI-PROJECT-23K24722
  • [Journal Article] Techniques for Injury, Cell Transplantation, and Histological Analysis in Skeletal Muscle2023

    • Author(s)
      Motohashi Norio、Minegishi Katsura、Imamura Michihiro、Aoki Yoshitsugu
    • Journal Title

      Methods in molecular biology (Clifton, N.J.)

      Volume: 2640 Pages: 193-205

    • DOI

      10.1007/978-1-0716-3036-5_14

    • ISBN
      9781071630358, 9781071630365
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K15447, KAKENHI-PROJECT-21K11615, KAKENHI-PROJECT-23K21412
  • [Journal Article] デュシェンヌ型筋ジストロフィーに対する全長型ジストロフィン補充療法の挑戦2023

    • Author(s)
      富成 司、青木 吉嗣
    • Journal Title

      遺伝子医学

      Volume: 13 Pages: 16-22

    • Data Source
      KAKENHI-PROJECT-23K05627
  • [Journal Article] Inherited myogenic abilities in muscle precursor cells defined by the mitochondrial complex I-encoding protein2023

    • Author(s)
      Motohashi Norio、Minegishi Katsura、Aoki Yoshitsugu
    • Journal Title

      Cell Death & Disease

      Volume: 14 Issue: 10 Pages: 689-689

    • DOI

      10.1038/s41419-023-06192-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K11615, KAKENHI-PROJECT-23K21412
  • [Journal Article] High‐intensity interval training in the form of isometric contraction improves fatigue resistance in dystrophin‐deficient muscle2023

    • Author(s)
      Yamauchi Nao、Tamai Katsuyuki、Kimura Iori、Naito Azuma、Tokuda Nao、Ashida Yuki、Motohashi Norio、Aoki Yoshitsugu、Yamada Takashi
    • Journal Title

      The Journal of Physiology

      Volume: 601 Issue: 14 Pages: 2917-2933

    • DOI

      10.1113/jp284532

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K11615, KAKENHI-PROJECT-21K19723, KAKENHI-PROJECT-23K21412, KAKENHI-PROJECT-23K21587
  • [Journal Article] Lipidomic Analyses Reveal Specific Alterations of Phosphatidylcholine in Dystrophic Mdx Muscle2022

    • Author(s)
      Valentine William J.、Mostafa Sherif A.、Tokuoka Suzumi M.、Hamano Fumie、Inagaki Natsuko F.、Nordin Joel Z.、Motohashi Norio、Kita Yoshihiro、Aoki Yoshitsugu、Shimizu Takao、Shindou Hideo
    • Journal Title

      Frontiers in Physiology

      Volume: 12 Pages: 698166-698166

    • DOI

      10.3389/fphys.2021.698166

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K11615, KAKENHI-PROJECT-22K08788, KAKENHI-PROJECT-23K21412
  • [Journal Article] Caveolin-3 regulates the activity of Ca<sup>2+</sup>/calmodulin-dependent protein kinase II in C2C12 cells2022

    • Author(s)
      Matsunobe Michio、Motohashi Norio、Aoki Eito、Tominari Tsukasa、Inada Masaki、Aoki Yoshitsugu
    • Journal Title

      American Journal of Physiology-Cell Physiology

      Volume: 323 Issue: 4 Pages: C1137-C1148

    • DOI

      10.1152/ajpcell.00077.2022

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K11615, KAKENHI-PROJECT-22K05490, KAKENHI-PROJECT-20H00574, KAKENHI-PROJECT-20H02534, KAKENHI-PROJECT-19KK0194, KAKENHI-PROJECT-23K21412, KAKENHI-PROJECT-23K24722
  • [Journal Article] Investigating the role of dystrophin isoform deficiency in motor function in Duchenne muscular dystrophy2022

    • Author(s)
      Chesshyre Mary、Ridout Deborah、Hashimoto Yasumasa、Ookubo Yoko、Torelli Silvia、Maresh Kate、Ricotti Valeria、Abbott Lianne、Gupta Vandana Ayyar、Main Marion、Ferrari Giulia、Kowala Anna、Lin Yung‐Yao、Tedesco Francesco Saverio、Scoto Mariacristina、Baranello Giovanni、Manzur Adnan、Aoki Yoshitsugu、Muntoni Francesco
    • Journal Title

      Journal of Cachexia, Sarcopenia and Muscle

      Volume: 13 Issue: 2 Pages: 1360-1372

    • DOI

      10.1002/jcsm.12914

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21J10198, KAKENHI-PROJECT-23K21412, KAKENHI-PROJECT-21H02067
  • [Journal Article] Clinical development of novel therapies for Duchenne muscular dystrophy-Current and future2022

    • Author(s)
      Tsukasa Tominari, Yoshitsugu Aoki
    • Journal Title

      Neurology and Clinical Neuroscience

      Volume: - Issue: 3 Pages: 12691-12691

    • DOI

      10.1111/ncn3.12691

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02067
  • [Journal Article] Size-tunable PEG-grafted copolymers as a polymeric nanoruler for passive targeting muscle tissues.2022

    • Author(s)
      M. Naito, Y. Watanuki, K. Toh, J. Yum, B. S. Kim, K. Taniwaki, S. Ogura, H. Ishida, M. Cho, H. Chaya, K. Miyajima, K. Osada, K. Minegishi, Y. Aoki, Y. Yamasaki, K. Miyata,
    • Journal Title

      Journal of Controlled Release

      Volume: 347 Pages: 607-614

    • DOI

      10.1016/j.jconrel.2022.05.030

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K19014, KAKENHI-PROJECT-17KK0102, KAKENHI-PROJECT-20H00658, KAKENHI-PROJECT-23K21412, KAKENHI-PROJECT-23K21857
  • [Journal Article] Development of Therapeutic RNA Manipulation for Muscular Dystrophy2022

    • Author(s)
      Saifullah, Norio Motohashi, Toshifumi Tsukahara, Yoshitsugu Aoki
    • Journal Title

      Front Genome Ed

      Volume: 4 Pages: 863651-863651

    • DOI

      10.3389/fgeed.2022.863651

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K11615, KAKENHI-PROJECT-22KF0410, KAKENHI-PROJECT-21H02067
  • [Journal Article] Dissociation of SH3 and cysteine-rich domain 3 and junctophilin 1 from dihydropyridine receptor in dystrophin-deficient muscles2022

    • Author(s)
      Ashida Yuki、Himori Koichi、Tokuda Nao、Naito Azuma、Yamauchi Nao、Takenaka-Ninagawa Nana、Aoki Yoshitsugu、Sakurai Hidetoshi、Yamada Takashi
    • Journal Title

      American Journal of Physiology-Cell Physiology

      Volume: 323 Issue: 3 Pages: C885-C895

    • DOI

      10.1152/ajpcell.00163.2022

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K19723, KAKENHI-PROJECT-20J01754, KAKENHI-PROJECT-21K17515, KAKENHI-PROJECT-23K21412, KAKENHI-PROJECT-23K21587
  • [Journal Article] Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy2022

    • Author(s)
      Hashimoto Yasumasa、Kuniishi Hiroshi、Sakai Kazuhisa、Fukushima Yuta、Du Xuan、Yamashiro Kunihiko、Hori Kei、Imamura Michihiro、Hoshino Mikio、Yamada Mitsuhiko、Araki Toshiyuki、Sakagami Hiroyuki、Takeda Shin’ichi、Itaka Keiji、Ichinohe Noritaka、Muntoni Francesco、Sekiguchi Masayuki、Aoki Yoshitsugu
    • Journal Title

      Progress in Neurobiology

      Volume: 216 Pages: 102288-102288

    • DOI

      10.1016/j.pneurobio.2022.102288

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K16603, KAKENHI-PROJECT-21J10198, KAKENHI-PROJECT-20K07752, KAKENHI-PROJECT-23K21412
  • [Journal Article] Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides2021

    • Author(s)
      Tone Yuichiro、Mamchaoui Kamel、Tsoumpra Maria K.、Hashimoto Yasumasa、Terada Reiko、Maruyama Rika、Gait Michael J.、Arzumanov Andrey A.、McClorey Graham、Imamura Michihiro、Takeda Shin'ichi、Yokota Toshifumi、Wood Matthew J.A.、Mouly Vincent、Aoki Yoshitsugu
    • Journal Title

      Nucleic Acid Therapeutics

      Volume: 31 Issue: 2 Pages: 172-181

    • DOI

      10.1089/nat.2020.0907

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07544, KAKENHI-PROJECT-21H02067
  • [Journal Article] Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient <i>mdx</i> mice2021

    • Author(s)
      Nogami Ken'ichiro、Maruyama Yusuke、Sakai-Takemura Fusako、Motohashi Norio、Elhussieny Ahmed、Imamura Michihiro、Miyashita Satoshi、Ogawa Megumu、Noguchi Satoru、Tamura Yuki、Kira Jun-ichi、Aoki Yoshitsugu、Takeda Shin'ichi、Miyagoe-Suzuki Yuko
    • Journal Title

      Human Molecular Genetics

      Volume: 30 Issue: 11 Pages: 1006-1019

    • DOI

      10.1093/hmg/ddab100

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02067, KAKENHI-PROJECT-21K11615, KAKENHI-PROJECT-20K15919, KAKENHI-PROJECT-19K07519
  • [Journal Article] Publisher Correction: Modelling Duchenne muscular dystrophy in MYOD1-converted urine-derived cells treated with 3-deazaneplanocin A hydrochloride2020

    • Author(s)
      Takizawa Hotake、Hara Yuko、Mizobe Yoshitaka、Ohno Taisuke、Suzuki Sadafumi、Inoue Ken、Takeshita Eri、Shimizu-Motohashi Yuko、Ishiyama Akihiko、Hoshino Mikio、Komaki Hirofumi、Takeda Shin’ichi、Aoki Yoshitsugu
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 1-11

    • DOI

      10.1038/s41598-020-59351-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Journal Article] Novel EGFP reporter cell and mouse models for sensitive imaging and quantification of exon skipping2020

    • Author(s)
      Hara Yuko、Mizobe Yoshitaka、Inoue Yukiko U.、Hashimoto Yasumasa、Motohashi Norio、Masaki Yoshiaki、Seio Kohji、Takeda Shin’ichi、Nagata Tetsuya、Wood Matthew J. A.、Inoue Takayoshi、Aoki Yoshitsugu
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 10110-10110

    • DOI

      10.1038/s41598-020-67077-4

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06467, KAKENHI-PROJECT-18K07544, KAKENHI-PROJECT-18K11067
  • [Journal Article] Dystrobrevin alpha gene is a direct target of the vitamin D receptor in muscle2020

    • Author(s)
      Tsoumpra Maria K、Sawatsubashi Shun、Imamura Michihiro、Fukumoto Seiji、Takeda Shin’ichi、Matsumoto Toshio、Aoki Yoshitsugu
    • Journal Title

      Journal of Molecular Endocrinology

      Volume: 64 Issue: 3 Pages: 195-208

    • DOI

      10.1530/jme-19-0229

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07544, KAKENHI-PROJECT-18K19518, KAKENHI-PROJECT-18K16236, KAKENHI-PROJECT-18KT0024
  • [Journal Article] Mutation-independent Proteomic Signatures of Pathological Progression in Murine Models of Duchenne Muscular Dystrophy2020

    • Author(s)
      van Westering Tirsa L.E.、Johansson Henrik J.、Hanson Britt、Coenen-Stass Anna M.L.、Lomonosova Yulia、Tanihata Jun、Motohashi Norio、Yokota Toshifumi、Takeda Shin'ichi、Lehti? Janne、Wood Matthew J.A.、EL Andaloussi Samir、Aoki Yoshitsugu、Roberts Thomas C.
    • Journal Title

      Molecular & Cellular Proteomics

      Volume: 19 Issue: 12 Pages: 2047-2068

    • DOI

      10.1074/mcp.ra120.002345

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09511, KAKENHI-PROJECT-18K07544, KAKENHI-PROJECT-18K11067
  • [Journal Article] Severe cardiac involvement with preserved truncated dystrophin expression in Becker muscular dystrophy by +1G>A DMD splice-site mutation: a case report2020

    • Author(s)
      Komaki Ryouhei、Hashimoto Yasumasa、Mori-Yoshimura Madoka、Oya Yasushi、Takizawa Hotake、Minami Narihiro、Nishino Ichizo、Aoki Yoshitsugu、Takahashi Yuji
    • Journal Title

      Journal of Human Genetics

      Volume: 65 Issue: 10 Pages: 903-909

    • DOI

      10.1038/s10038-020-0788-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Journal Article] Peptide-conjugate antisense based splice-correction for Duchenne muscular dystrophy and other neuromuscular diseases2019

    • Author(s)
      Tsoumpra Maria K.、Fukumoto Seiji、Matsumoto Toshio、Takeda Shin'ichi、Wood Matthew J.A.、Aoki Yoshitsugu
    • Journal Title

      EBioMedicine

      Volume: 45 Pages: 630-645

    • DOI

      10.1016/j.ebiom.2019.06.036

    • NAID

      120006941112

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07544, KAKENHI-PROJECT-18K16236
  • [Journal Article] Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes.2019

    • Author(s)
      Sato M, Shiba N, Miyazaki D, Shiba Y, Echigoya Y, Yokota T, Takizawa H, Aoki Y, Takeda S, Nakamura A.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 520 Issue: 1 Pages: 179-185

    • DOI

      10.1016/j.bbrc.2019.09.095

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02577, KAKENHI-PROJECT-18H02887, KAKENHI-PROJECT-18K15026, KAKENHI-PROJECT-18K14595
  • [Journal Article] Potential Therapies Using Myogenic Stem Cells Combined with Bio-Engineering Approaches for Treatment of Muscular Dystrophies2019

    • Author(s)
      Motohashi Norio、Shimizu-Motohash Yuko、Roberts Thomas、Aoki Yoshitsugu
    • Journal Title

      Cells

      Volume: 8 Issue: 9 Pages: 1066-1066

    • DOI

      10.3390/cells8091066

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07544, KAKENHI-PROJECT-18K11067
  • [Journal Article] Application of Urine-Derived Stem Cells to Cellular Modeling in Neuromuscular and Neurodegenerative Diseases2019

    • Author(s)
      Sato Mitsuto、Takizawa Hotake、Nakamura Akinori、Turner Bradley J.、Shabanpoor Fazel、Aoki Yoshitsugu
    • Journal Title

      Frontiers in Molecular Neuroscience

      Volume: 12 Pages: 1-9

    • DOI

      10.3389/fnmol.2019.00297

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07544, KAKENHI-PROJECT-18H02577
  • [Journal Article] Restoring Dystrophin Expression in Duchenne Muscular Dystrophy: Current Status of Therapeutic Approaches2019

    • Author(s)
      Shimizu-Motohashi Yuko、Komaki Hirofumi、Motohashi Norio、Takeda Shin’ichi、Yokota Toshifumi、Aoki Yoshitsugu
    • Journal Title

      Journal of Personalized Medicine

      Volume: 9 Issue: 1 Pages: 1-1

    • DOI

      10.3390/jpm9010001

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07544, KAKENHI-PROJECT-18K11067
  • [Journal Article] Autoimmune response and its long‐term consequences after exon‐skipping therapy in a Duchenne muscular dystrophy mouse model2019

    • Author(s)
      Nordin Joel Z、Aoki Yoshitsugu
    • Journal Title

      The Journal of Pathology

      Volume: 249 Issue: 3 Pages: 271-273

    • DOI

      10.1002/path.5327

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07544, KAKENHI-PROJECT-19K16849
  • [Journal Article] Modelling Duchenne muscular dystrophy in MYOD1-converted urine-derived cells treated with 3-deazaneplanocin A hydrochloride2019

    • Author(s)
      Takizawa Hotake、Hara Yuko、Mizobe Yoshitaka、Ohno Taisuke、Suzuki Sadafumi、Inoue Ken、Takeshita Eri、Shimizu-Motohashi Yuko、Ishiyama Akihiko、Hoshino Mikio、Komaki Hirofumi、Takeda Shin’ichi、Aoki Yoshitsugu
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 3807-3807

    • DOI

      10.1038/s41598-019-40421-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-16H06528, KAKENHI-PROJECT-16H05361, KAKENHI-PROJECT-18H02538, KAKENHI-PROJECT-15H04268, KAKENHI-PROJECT-18K07544
  • [Journal Article] Truncated dystrophin ameliorates the dystrophic phenotype of mdx mice by reducing sarcolipin-mediated SERCA inhibition2018

    • Author(s)
      Tanihata Jun、Nagata Tetsuya、Ito Naoki、Saito Takashi、Nakamura Akinori、Minamisawa Susumu、Aoki Yoshitsugu、Ruegg Urs T.、Takeda Shin'ichi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 505 Issue: 1 Pages: 51-59

    • DOI

      10.1016/j.bbrc.2018.09.039

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01529, KAKENHI-PROJECT-16K08726, KAKENHI-PROJECT-16K15184, KAKENHI-PROJECT-16H05221
  • [Journal Article] Systemic Delivery of Morpholinos to Skip Multiple Exons in a Dog Model of Duchenne Muscular Dystrophy.2017

    • Author(s)
      Maruyama R, Echigoya Y, Caluseriu O, Aoki Y, Takeda S, Yokota T
    • Journal Title

      Methods Mol Biol.

      Volume: 1565 Pages: 201-213

    • DOI

      10.1007/978-1-4939-6817-6_17

    • ISBN
      9781493968152, 9781493968176
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Journal Article] Duchenne型筋ジストロフィーに対するエクソンスキップ薬開発の試み2016

    • Author(s)
      青木吉嗣
    • Journal Title

      Clinical Neuroscience

      Volume: 34 Pages: 355-358

    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Journal Article] Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy.2016

    • Author(s)
      Miskew Nichols B, Aoki Y, Kuraoka M, Lee JJ, Takeda S, Yokota T
    • Journal Title

      J Vis Exp.

      Volume: 24 Issue: 111 Pages: 111-111

    • DOI

      10.3791/53776

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Journal Article] Recent advances in innovative therapeutic approaches for Duchenne muscular dystrophy: from discovery to clinical trials.2016

    • Author(s)
      Shimizu-Motohashi Y, Miyatake S, Komaki H, Takeda S, Aoki Y
    • Journal Title

      Am J Transl Res.

      Volume: 8 Pages: 2471-2489

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Journal Article] Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot.2016

    • Author(s)
      Suzuki H, Aoki Y, Kameyama T, Saito T, Masuda S, Tanihata J, Nagata T, Mayeda A, Takeda S, Tsukahara T
    • Journal Title

      Int J Mol Sci.

      Volume: 17

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Journal Article] Anti-inflammatory drugs for Duchenne muscular dystrophy: focus on skeletal muscle-releasing factors.2016

    • Author(s)
      Miyatake S, Shimizu-Motohashi Y, Takeda S, Aoki Y
    • Journal Title

      Drug Des Devel Ther.

      Volume: 10 Pages: 2745-2758

    • DOI

      10.2147/dddt.s110163

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Journal Article] Deletion of exons 3-9 encompassing a mutational hot spot in the DMD gene presents an asymptomatic phenotype, indicating a target region for multiexon skipping therapy.2016

    • Author(s)
      Nakamura A, Fueki N, Shiba N, Motoki H, Miyazaki D, Nishizawa H, Echigoya Y, Yokota T, Aoki Y, Takeda S.
    • Journal Title

      J Hum Genet

      Volume: 61 Issue: 7 Pages: 663-667

    • DOI

      10.1038/jhg.2016.28

    • NAID

      40020884111

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460666, KAKENHI-PROJECT-15H06883
  • [Journal Article] Recent advances in innovative therapeutic approaches for Duchenne muscular dystrophy: from discovery to clinical trials2016

    • Author(s)
      Yuko Shimizu-Motohashi, Hirofumi Komaki, Shin’ichi Takeda, Yoshitsugu Aoki
    • Journal Title

      American Journal of Translational Research

      Volume: 00 Pages: 00-00

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Patent] エクソン50のスキッピングを誘導するアンチセンス核酸2020

    • Inventor(s)
      青木吉嗣
    • Industrial Property Rights Holder
      青木吉嗣
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Patent] エクソン51のスキッピングを誘導するアンチセンス核酸2020

    • Inventor(s)
      青木吉嗣
    • Industrial Property Rights Holder
      青木吉嗣
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Patent] アンチセンス核酸(エクソン45)2020

    • Inventor(s)
      青木吉嗣
    • Industrial Property Rights Holder
      青木吉嗣
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Acquisition Date
      2020
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Presentation] 廃用性筋萎縮における筋量制御因子の網羅解析2023

    • Author(s)
      富成司、髙戸谷賢、新井大地、平田美智子、青木吉嗣、稲田全規
    • Organizer
      第9回日本筋学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K05627
  • [Presentation] 筋特異的ユビキチンリガーゼMuRF1を介した筋萎縮病態の解明2023

    • Author(s)
      富成司、青木鋭人、青木吉嗣
    • Organizer
      第16回筋ジストロフィー治療研究会
    • Data Source
      KAKENHI-PROJECT-23K05627
  • [Presentation] 廃用性筋萎縮における筋分解関連因子の時系列的な発現変動2023

    • Author(s)
      富成司、髙戸谷賢、新井大地、平田美智子、青木吉嗣、稲田全規
    • Organizer
      第41回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K05627
  • [Presentation] 廃用性筋萎縮モデルマウスを用いた遺伝子発現の網羅解析2023

    • Author(s)
      春日麗、富成司、松本千穂、平田美智子、青木吉嗣、稲田 全規
    • Organizer
      第41回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K05627
  • [Presentation] デュシェンヌ型筋ジストロフィーに対するMuse細胞を用いた治療研究2023

    • Author(s)
      青木鋭人、富成司、本橋紀夫、稲田全規、青木吉嗣
    • Organizer
      東京農工大学ー国立精神・神経医療研究センター 第7回合同シンポジウム
    • Data Source
      KAKENHI-PROJECT-23K05627
  • [Presentation] デュシェンヌ型筋ジストロフィーに対する創薬開発とアンチセンス核酸医薬2021

    • Author(s)
      青木吉嗣
    • Organizer
      第20回日本再生医療学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Presentation] デュシェンヌ型筋ジストロフィーのエクソン・スキップ治療2020

    • Author(s)
      青木吉嗣
    • Organizer
      第38回日本神経治療学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Presentation] デュシェンヌ型筋ジストロフィーに対する核酸医薬品開発の最新知見2020

    • Author(s)
      青木吉嗣
    • Organizer
      第415回CBI学会講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Presentation] デュシェンヌ型筋ジストロフィーのエクソン・スキップ治療2020

    • Author(s)
      青木吉嗣
    • Organizer
      第6回日本筋学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Presentation] DMD患者由来心筋細胞における分化・再生関連遺伝子の発現低下と心筋障害への影響に関する研究2019

    • Author(s)
      宮崎大吾、柴直子、佐藤充人、柴祐司、越後谷裕介、横田俊文、溝部吉高、青木吉嗣、武田伸一、中村昭則
    • Organizer
      第14回筋ジストロフィー治療研究会
    • Data Source
      KAKENHI-PROJECT-18H02577
  • [Presentation] 神経筋難病の遺伝子を標的にした治療法開発2019

    • Author(s)
      青木吉嗣
    • Organizer
      神経治療学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Presentation] Truncated dystrophin ameliorates the dystrophic phenotype by sarcolipin-mediated SERCA inhibition.2019

    • Author(s)
      Tanihata J, Nagata T, Ito N, Saito T, Nakamura A, Minamisawa S, Aoki Y, Urs T, Takeda S
    • Organizer
      FAOPS 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08726
  • [Presentation] Targeting RNA to treat Duchenne muscular dystrophy2019

    • Author(s)
      青木吉嗣
    • Organizer
      CNMC International Conference
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Presentation] DMD遺伝子exon46-55欠失変異を持つDMD患者iPSC由来心筋細胞に対するexon 45 skip治療に関する研究2019

    • Author(s)
      佐藤充人、宮崎大吾、柴直子、柴祐司、越後谷裕介、横田俊文、青木吉嗣、武田伸一、中村昭則
    • Organizer
      日本筋学会第5回学術集会
    • Data Source
      KAKENHI-PROJECT-18H02577
  • [Presentation] Gene expression in cardiomyocytes from DMD with exon 46-55 deletion after exon 45 skipping therapy.2019

    • Author(s)
      Miyazaki D., Sato M., Shiba N., Shiba Y., Echigoya Y., Yokota T., Aoki Y., Takeda S., Nakamura A.
    • Organizer
      60th Annual Meeting of The Japanese Society of Neurology
    • Data Source
      KAKENHI-PROJECT-18H02577
  • [Presentation] ジストロフィン欠損と加齢による骨格筋萎縮発症の分子機序解明2019

    • Author(s)
      青木吉嗣
    • Organizer
      東京農工大学―NCNP 第 5 回合同シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Presentation] Advanced PPMO combinations drive multi-exon skipping and dystrophin expression in dystrophic dogs2019

    • Author(s)
      青木吉嗣
    • Organizer
      48th European Muscle Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Presentation] Dystrophin networks in the brain of mdx and mdx52 mice2019

    • Author(s)
      青木吉嗣
    • Organizer
      249th European Neuromuscular Centre International Workshop
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Presentation] DMD病態における細胞内Ca2+動態異常2018

    • Author(s)
      谷端 淳,永田哲也,中村昭則,青木吉嗣,Urs Ruegg,南沢 享,武田伸一
    • Organizer
      日本筋学会第4回学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K08726
  • [Presentation] Significance of animal experimentation to drug development for muscular dystrophy2018

    • Author(s)
      青木吉嗣
    • Organizer
      UCL London lecture
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07544
  • [Presentation] Cytosolic Ca2+ dynamics through the SR is associated with pathology of muscular dystrophy.2017

    • Author(s)
      6)Tanihata J, Nagata T, Ito N, Saito T, Nakamura A, Minamisawa S, Aoki Y, Takeda S
    • Organizer
      第3回Neo Vitamin D Workshop学術集会
    • Data Source
      KAKENHI-PROJECT-16K08726
  • [Presentation] 筋ジストロフィー病態における細胞内Ca2+動態の解明と新たな治療法の開発2017

    • Author(s)
      7)谷端 淳,永田哲也,伊藤尚基,齊藤 崇,中村昭則,南沢 享,青木吉嗣,武田伸一
    • Organizer
      日本筋学会第3回学術集会
    • Data Source
      KAKENHI-PROJECT-16K08726
  • [Presentation] Cytosolic Ca2+ Dynamics Through the SR is Associated with Pathology of Muscular Dystrophy.2017

    • Author(s)
      2)Tanihata J, Nagata T, Ito N, Saito T, Nakamura A, Minamisawa S, Aoki Y, Takeda S
    • Organizer
      20th International Symposium on Calcium Binding Proteins and Calcium Function in Health and Disease (CaBP20)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08726
  • [Presentation] Functional analysis of MyoD-transduced fibroblasts and urine-derived cells from healthy individual and patients with Duchenne muscular dystrophy.2017

    • Author(s)
      4)Takizawa H, Hara Y, Miyatake S, Tanihata J, Mizobe Y, Saito T, Takeda S, Aoki Y:
    • Organizer
      XXII World Congress of Neurology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08726
  • [Presentation] デュシェンヌ型筋ジストロフィーに対するエクソン・スキップ治療法開発の現状と課題2016

    • Author(s)
      青木吉嗣
    • Organizer
      国立国際医療研究センター先進医療開発部門セミナー
    • Place of Presentation
      東京
    • Year and Date
      2016-10-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Presentation] エクソンスキッピング・核酸医薬の研究開発の状況と今後の展望2016

    • Author(s)
      青木吉嗣
    • Organizer
      第15期バイオファイナンスギルド第3回セミナー
    • Place of Presentation
      東京
    • Year and Date
      2016-10-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Presentation] デュシェンヌ型筋ジストロィーに対するアンチセンス核酸医薬品開発の試み2016

    • Author(s)
      青木吉嗣
    • Organizer
      第2回Neo Vitamin D Workshop 学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-08-26
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Presentation] Development of LNA Gapmer Oligonucleotide Based Therapy for ALS/FTD Caused by the C9ORF72 Repeat Expansion2016

    • Author(s)
      青木吉嗣
    • Organizer
      ASGCT
    • Place of Presentation
      東京
    • Year and Date
      2016-05-07
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Presentation] 筋ジストロフィー病態における細胞内Ca2+動態の解明と新たな治療法の開発2016

    • Author(s)
      谷端 淳、永田哲也、伊藤尚基、斎藤 崇、青木吉嗣、武田伸一
    • Organizer
      第71回日本体力医学会
    • Place of Presentation
      盛岡
    • Year and Date
      2016-09-23
    • Data Source
      KAKENHI-PROJECT-16K08726
  • [Presentation] Duchenne型筋ジストロフィーに対するRNA治療薬開発の現状と課題2016

    • Author(s)
      青木吉嗣
    • Organizer
      第2回日本筋学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-08-06
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Presentation] 遺伝性神経・筋難病に対する新規ペプチド付加核酸治療法の開発2016

    • Author(s)
      青木吉嗣
    • Organizer
      連携大学院山梨大学,NCNP合同シンポジウム
    • Place of Presentation
      東京都小平市
    • Year and Date
      2016-01-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Presentation] NCNPにおける橋渡し研究の現状.筋ジストロフィーに対するエクソン・スキップ治療法開発2016

    • Author(s)
      青木吉嗣
    • Organizer
      第12回神経内科短期臨床研修セミナー
    • Place of Presentation
      東京
    • Year and Date
      2016-07-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Presentation] Sarcolipin deletion ameliorates the dystrophic phenotype of2016

    • Author(s)
      谷端 淳, 永田 哲也, 伊藤 尚基, 齋藤 崇, 中村 昭則, 南沢 享, 青木 吉嗣, 武田 伸一
    • Organizer
      第2回日本筋学会
    • Place of Presentation
      東京
    • Year and Date
      2016-08-05
    • Data Source
      KAKENHI-PROJECT-16K08726
  • [Presentation] Cytosolic Ca2+ dynamics through the SR is associated with pathology of muscular dystrophy2016

    • Author(s)
      Jun Tanihata, Tetsuya Nagata, Ito Naoki, Takashi Saito, Akinori Nakamura, Yoshitsugu Aoki, Shin’ichi Takeda
    • Organizer
      Society for muscle biology
    • Place of Presentation
      カリフォルニア
    • Year and Date
      2016-06-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08726
  • [Presentation] 筋ジストロフィー病態における筋小胞体を介した細胞内 Ca2+動態の解明2015

    • Author(s)
      谷端 淳,永田哲也,伊藤尚基,齊藤 崇,青木吉嗣,武田伸一
    • Organizer
      第1 回日本筋学会学術集会
    • Place of Presentation
      国立精神・神経医療研究センター教育研修棟ユニバーサルホール(東京都 小平市)
    • Year and Date
      2015-08-08
    • Data Source
      KAKENHI-PROJECT-25282202
  • [Presentation] 筋ジストロフィー病態における細胞内Ca2+動態の解明と新たな治療法の開発2015

    • Author(s)
      谷端 淳,永田哲也,伊藤尚基,青木吉嗣,齊藤 崇,中村昭則,武田伸一
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山県民文化会館/ホテルアバローム紀の国(和歌山)
    • Year and Date
      2015-09-18
    • Data Source
      KAKENHI-PROJECT-25282202
  • [Presentation] Cytosolic Ca2+ dynamics through the SR is associated with pathology of muscular dystrophy.2015

    • Author(s)
      Tanihata J, Nagata T, Ito N, Saito T, Aoki Y, Nakamura A, Takeda S
    • Organizer
      10th Japanese-French Workshop
    • Place of Presentation
      Cite Internationale Universitaire(Paris France)
    • Year and Date
      2015-07-02
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25282202
  • [Presentation] 筋ジストロフィーに対する新規核酸治療法の開発2015

    • Author(s)
      青木吉嗣
    • Organizer
      第1回Neo Vitamin D Workshop 学術集会
    • Place of Presentation
      滋賀県大津市
    • Year and Date
      2015-08-28
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H06883
  • [Presentation] Exon45-55を欠失した短縮型ジストロフィンはnNOSの局在を変化させRyR1をニトロシル化し、細胞内Ca2+濃度を上昇させる2014

    • Author(s)
      武田伸一,谷端 淳,永田哲也,齊藤 崇,伊藤尚基,青木吉嗣,中村昭則
    • Organizer
      国立精神・神経医療研究センター精神・神経疾患研究開発費25-5「筋ジストロフィーモデル動物を用いた新たな治療法の開発」(主任研究者:武田伸一)平成26年度班会議
    • Place of Presentation
      千代田区 JA共済ビル カンファレンスホール
    • Year and Date
      2014-12-03
    • Data Source
      KAKENHI-PROJECT-25282202
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