Hayashi Ken 林賢

… Alternative Names

HAYASHI Ken 林賢

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Researcher Number	80534528
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 共同研究員
Affiliation (based on the past Project Information) *help	2019 – 2023: 慶應義塾大学, 医学部(信濃町), 共同研究員
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator エクソソーム / オートファジー / 老化ミクログリア / DAMPs / 内耳細胞死 / 酸化ストレス / SASP / 内耳細胞老化 / LaminB1 / cGAS-STING … More / Nucleophagy / NaAsO2 / 耳鳴 / Toll-Like-Receptor 7 / miRNA let-7b / CMOS-アレイ / ミスマッチ陰性電位 / 内耳細胞過興奮性細胞死 / CMOS-MEA / 初代培養神経細胞 / TLR-7 / 初代神経培養細胞 / 間歇的自発バースト / ミスマッチネガティビティ / 異種細胞間コミュニケーション / エクソソームmiRNA let-7b Less

内耳細胞死由来エクソソーム・DAMPsが海馬の空間情報処理に及ぼす影響の解明Principal Investigator
- Principal Investigator
  
  林賢
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Keio University
Cross-talk analysis between heterotypic cell-cell communication via siRNA/TLR7 and new therapeutic strategyPrincipal Investigator
- Principal Investigator
  
  HAYASHI Ken
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Fine-tuned cholesterol solubilizer, mono-6-O-α-D-maltosyl-γ-cyclodextrin, ameliorates experimental Niemann?Pick disease type C without hearing loss2022
- Author(s)
  Yamada Y, Miwa T, Nakashima M, Shirakawa A, Ishii A, Namba N, Kondo Y, Takeo T, Nakagata N, Motoyama K, Higashi T, Arima H, Kurauchi Y, Seki T, Katsuki H, Okada Y, Ichikawa A, Higaki K, Hayashi K, Minami K, Yoshikawa N, Ikeda R, Ishikawa Y, Kajii T, Tachii K, Takeda H, Orita Y, Matsuo M, Irie T, Ishitsuka Y
- Journal Title
  
  Biomedicine & Pharmacotherapy
  
  Volume: 155 Pages: 113698-113698
- DOI
  10.1016/j.biopha.2022.113698
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06596, KAKENHI-PROJECT-21K07821, KAKENHI-PROJECT-22K06631, KAKENHI-PROJECT-22K09674, KAKENHI-PROJECT-19K22972, KAKENHI-PROJECT-21K15316, KAKENHI-PROJECT-19K09899, KAKENHI-PROJECT-20K07066, KAKENHI-PROJECT-20K16080
[Journal Article] Molecular Mechanisms and Biological Functions of Autophagy for Genetics of Hearing Impairment.2020
- Author(s)
  Ken Hayashi, Yuna Suzuki Y, Chisato Fujimoto, Sho Kanzaki
- Journal Title
  
  Genes
  
  Volume: 11 Issue: 11 Pages: 1331-1331
- DOI
  10.3390/genes11111331
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09899, KAKENHI-PROJECT-18K09369
[Journal Article] Casper-8 Regulates Endoplasmic Reticulum Stress-Induced Necroptosis Independent of the Apotosis Pathway in Auditor Cells2019
- Author(s)
  Kishino A, Hayashi K, Maeda M, Jike T, Hidai C, Nomura Y, Oshima T.
- Journal Title
  
  Int J. Mol. Sci.
  
  Volume: 20(23) Issue: 23 Pages: 5896-5896
- DOI
  10.3390/ijms20235896
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09358, KAKENHI-PROJECT-19K09899, KAKENHI-PROJECT-19K09916, KAKENHI-PROJECT-19K18747
[Presentation] TFEB活性低下とリソソーム損傷が内耳細胞老化に及ぼす影響2023
- Author(s)
  林　賢、五島史行、野村泰之、鴨頭輝，藤本千里
- Organizer
  第124回日本耳鼻咽喉科頭頸部外科学会総会・学術講演会第3群　耳研究1
- Data Source
  KAKENHI-PROJECT-22K09674
[Presentation] TFEB,オートファジー・リソソーム経路, 細胞内ROS間のクロストークによる内耳細胞老化制御2023
- Author(s)
  林　賢、五島史行、野村泰之、鴨頭輝，藤本千里
- Organizer
  第33回　日本耳科学会総会・学術講演会第15群　基礎2　第５会場
- Data Source
  KAKENHI-PROJECT-22K09674
[Presentation] 酸化ストレス誘導性内耳細胞老化におけるTFEBを焦点としたオートファジー・リソソーム経路制御機構の解明2023
- Author(s)
  林　賢、鈴木佑奈、槇島　誠
- Organizer
  第23回日本抗加齢医学会総会一般口演10　「細胞基礎 / 細胞臨床」
- Data Source
  KAKENHI-PROJECT-22K09674
[Presentation] TFEBによるオートファジー・リソソーム経路活性化を介した内耳細胞老化制御メカニズムの解明2022
- Author(s)
  林　賢
- Organizer
  第32回　日本耳科学会　総会・学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-22K09674
[Presentation] TFEBによるオートファジー・リソソーム経路活性化を介した内耳細胞老化制御メカニズムの解明2022
- Author(s)
  林　賢
- Organizer
  第32回　日本耳科学会　総会・学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] Exosomal miRNA let-7b modulates the interaction between TLR7 and TRPA1, inducing hyperexcitability-induced cell death in auditory cell2022
- Author(s)
  Ken Hayashi, Hideaki Sakata
- Organizer
  49th Congress of the Neurootological and Equilibriometric Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] Exosomal miRNA let-7b modulates the interaction between TLR7 and TRPA1, inducing hyperexcitability-induced cell death in auditory cell2022
- Author(s)
  Ken Hayashi, Hideaki Sakata
- Organizer
  49th Congress of the Neurootological and equillibriometric society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09674
[Presentation] The functions of exosomal miRNA let-7b as a top-down signal disrupting the neural network in the auditory-brain2022
- Author(s)
  Ken Hayashi, Hideaki Sakata
- Organizer
  49th Congress of the Neurootological and Equilibriometric Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] The functions of exosomal miRNA let-7b as a top-down signal disrupting the neural network in the auditory-brain2022
- Author(s)
  Ken Hayashi, Hideaki Sakata
- Organizer
  49th Congress of the Neurootological and equillibriometric society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09674
[Presentation] The effect of exosomal miRNA let-7b to the mismatch negativity as an auditory memory traces in cellular neural network.2021
- Author(s)
  Ken Hayashi, Yuna Suzuki, Fumiyuki Goto, Yasuyuki Nomura, Sho Kanzaki, Chisato Fujimoto.
- Organizer
  The 125th American Academy Otolaryngology-Head and Neck Surgery Foundation Annual Meeting & OTO EXPO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] Exosomal miRNA let-7b inducing hyperexcitability-induced auditory cell death decrease the auditory sensorial memory in cellular neural network2021
- Author(s)
  Ken Hayashi Hideaki Sakata1
- Organizer
  The 48th NES Congress online
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] The impact of extracellular miRNA let-7b as a top-down signal in the auditory-brain.2020
- Author(s)
  Ken Hayashi, Yuna Suzuki, Fumiyuki Goto, Akihiro Kishino, and Kaoru Ogawa
- Organizer
  American Academy Otolaryngology-Head and Neck Surgery Foundation Annual Meeting & OTO EXPO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] The interaction of TRL7 with TRPA1 drives hyperexcitability cell death modulated by miRNA let-7b in auditory cells.2020
- Author(s)
  Ken Hayashi, Yuna Suzuki, Akihiro Kishino, Fumiyuki Goto, Kaoru Ogawa
- Organizer
  43RD Association of research in Otolaryngology, Midwinter Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] Autophagy Signaling Mechanisms Controlling Cell Fate in Auditory Cells -Cell death and Cellular Senescence-2019
- Author(s)
  Ken Hayashi
- Organizer
  The 25th Ajou Otology Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] The effect of hyperexcitability-induced cell death modulated by miRNA let-7b in the auditory-brain2019
- Author(s)
  Ken Hayashi, Fumiyuki Goto, Yuna Suzuki, Akihiro Kishino, Sho Kanzaki, Kaoru Ogawa
- Organizer
  12thAPSCI
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] TLR7-TRPA1 interaction drives hyperexcitability cell death modulated by miRNA let-7b in auditory cells2019
- Author(s)
  Ken Hayashi, Fumiyuki Goto, Akihiro Kishino, Yuna Suzuki, Yasuyuki Nomura, Sho Kanzaki, Kaoru Ogawa
- Organizer
  ICORL 2019 Symposium, Basic research in hearing loss
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899
[Presentation] The cross-talk between exosomal miRNA, apoptosis and autophagy in auditory cell death2019
- Author(s)
  Ken Hayashi, Fumiyuki Goto, Akihiro Kishino, Yuna Suzuki, Yasuyuki Nomura, Sho Kanzaki, Kaoru Ogawa
- Organizer
  123thAAO-HNSF
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09899

1. 神崎晶 (50286556)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. 高橋宏知 (90361518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 高島明彦 (00154774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. IRIE Tetsumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. ISHITSUKA Youichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. TAKEO Toru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. KONDO Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 日台智明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 野村泰之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayashi Ken 林 賢

HAYASHI Ken 林 賢

Research Projects

Research Products

Co-Researchers

内耳細胞死由来エクソソーム・DAMPsが海馬の空間情報処理に及ぼす影響の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cross-talk analysis between heterotypic cell-cell communication via siRNA/TLR7 and new therapeutic strategyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Fine-tuned cholesterol solubilizer, mono-6-O-α-D-maltosyl-γ-cyclodextrin, ameliorates experimental Niemann?Pick disease type C without hearing loss2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular Mechanisms and Biological Functions of Autophagy for Genetics of Hearing Impairment.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Casper-8 Regulates Endoplasmic Reticulum Stress-Induced Necroptosis Independent of the Apotosis Pathway in Auditor Cells2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] TFEB活性低下とリソソーム損傷が内耳細胞老化に及ぼす影響2023

Author(s)

Organizer

Data Source

[Presentation] TFEB,オートファジー・リソソーム経路, 細胞内ROS間のクロストークによる内耳細胞老化制御2023

Author(s)

Organizer

Data Source

[Presentation] 酸化ストレス誘導性内耳細胞老化におけるTFEBを焦点としたオートファジー・リソソーム経路制御機構の解明2023

Author(s)

Organizer

Data Source

[Presentation] TFEBによるオートファジー・リソソーム経路活性化を介した内耳細胞老化制御メカニズムの解明2022

Author(s)

Organizer

Data Source

[Presentation] TFEBによるオートファジー・リソソーム経路活性化を介した内耳細胞老化制御メカニズムの解明2022

Author(s)

Organizer

Data Source

[Presentation] Exosomal miRNA let-7b modulates the interaction between TLR7 and TRPA1, inducing hyperexcitability-induced cell death in auditory cell2022

Author(s)

Organizer

Data Source

[Presentation] Exosomal miRNA let-7b modulates the interaction between TLR7 and TRPA1, inducing hyperexcitability-induced cell death in auditory cell2022

Author(s)

Organizer

Data Source

[Presentation] The functions of exosomal miRNA let-7b as a top-down signal disrupting the neural network in the auditory-brain2022

Author(s)

Organizer

Data Source

[Presentation] The functions of exosomal miRNA let-7b as a top-down signal disrupting the neural network in the auditory-brain2022

Author(s)

Organizer

Data Source

[Presentation] The effect of exosomal miRNA let-7b to the mismatch negativity as an auditory memory traces in cellular neural network.2021

Author(s)

Organizer

Data Source

[Presentation] Exosomal miRNA let-7b inducing hyperexcitability-induced auditory cell death decrease the auditory sensorial memory in cellular neural network2021

Author(s)

Organizer

Data Source

[Presentation] The impact of extracellular miRNA let-7b as a top-down signal in the auditory-brain.2020

Author(s)

Organizer

Data Source

Hayashi Ken 林賢

HAYASHI Ken 林賢