Takahashi Hironori 高橋宏典

Researcher Number	80544303
Other IDs	https://orcid.org/0000-0003-1652-9438
Affiliation (Current)	2024: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 自治医科大学, 医学部, 教授 2017 – 2018: 自治医科大学, 医学部, 准教授 2016: 自治医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related
Keywords	Principal Investigator バイオマーカー / マイクロRNA / 絨毛外栄養膜 / 妊娠高血圧症候群 / 早産 / microRNA / 妊娠高血圧腎症 / エクソソーム / 妊娠初期 / デジタルPCR … More / 癒着胎盤 / 産科学 / 分娩 / グロースファクター / サイトカイン / 妊娠糖尿病 / 妊娠 / 胎盤 / 絨毛膜外栄養膜 / WNT … More Except Principal Investigator 胎盤 / 産科学 / 細胞外ナノ粒子 / 予知 / 細胞外小胞 / フローサイトメトリー法 / 胎盤由来エクソソーム / PLAP / ELISA / CD9 / エクソソーム / 妊娠高血圧腎症 / 心血管疾患 / 妊娠期 / サルコペニア / DROSHA / 妊娠 Less

胎盤由来細胞間輸送体の新パラダイムによる妊娠高血圧腎症・早産の病態解明と発症予知
- Principal Investigator
  
  瀧澤俊広
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
妊娠期におけるサルコペニア肥満の臨床的意義に関する研究
- Principal Investigator
  
  江川真希子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Tokyo Medical and Dental University
A novel prediction of placenta accreta spectrum using circulating microRNA in in the first trimesterPrincipal Investigator
- Principal Investigator
  
  高橋宏典
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Jichi Medical University
胎盤由来エクソソームによる妊娠高血圧腎症の予知法に関する研究
- Principal Investigator
  
  鈴木寛正
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Jichi Medical University
Elucidation of the novel function of trophoblast DROSHA as a novel therapeutic strategy for preventing congenital viral infection
- Principal Investigator
  
  瀧澤俊広
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
妊娠初期における超早産バイオマーカー探索:エクソソーム中胎盤特異的miRNAPrincipal Investigator
- Principal Investigator
  
  高橋宏典
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Jichi Medical University
The comprehensive microRNA analysis and an etiologic study for early-onset preeclampsiaPrincipal Investigator
- Principal Investigator
  
  Takahashi Hironori
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Jichi Medical University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Elevated S100A9 in preeclampsia induces soluble endoglin and IL-1b secretion and hypertension via the NLRP3 inflammasome.2022
- Author(s)
  Ozeki A, Oogaki Y, Henmi Y, Karasawa T, Takahashi M, Takahashi H, Ohkuchi A, Shirasuna K
- Journal Title
  
  J Hypertens
  
  Volume: 40 Issue: 1 Pages: 84-93
- DOI
  10.1097/hjh.0000000000002981
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09655, KAKENHI-PROJECT-19K18650
[Journal Article] Non-coding RNAs and prediction of preeclampsia in the first trimester of pregnancy2022
- Author(s)
  Manabu Ogoyama, Hironori Takahashi, Hirotada Suzuki, Akihide Ohkuchi, Hiroyuki Fujiwara, Toshihiro Takizawa
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 15 Pages: 2428-2428
- DOI
  10.3390/cells11152428
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09611, KAKENHI-PROJECT-22K16863
[Journal Article] LncRNA H19-derived miR-675-5p accelerates the invasion of extravillous trophoblast cells by inhibiting GATA2 and subsequently activating matrix metalloproteinases2021
- Author(s)
  Ogoyama M, Ohkuchi A, Takahashi H, Zhao D, Matsubara S, Takizawa T
- Journal Title
  
  Int J Mol Sci
  
  Volume: 22 Issue: 3 Pages: 1237-1237
- DOI
  10.3390/ijms22031237
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09611, KAKENHI-PROJECT-19K18650
[Journal Article] β-hydroxybutyrate suppresses NLRP3 inflammasome-mediated placental inflammation and lipopolysaccharide-induced fetal absorption.2021
- Author(s)
  Hirata Y, Shimazaki S, Suzuki S, Henmi Y, Komiyama H, Kuwayama T, Iwata H, Karasawa T, Takahashi M, Takahashi H, Shirasuna K
- Journal Title
  
  J Reproductive Immunology
  
  Volume: 148 Pages: 103433-103433
- DOI
  10.1016/j.jri.2021.103433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09655, KAKENHI-PROJECT-19K18650
[Journal Article] Extravillous trophoblast invasion accelerated by WNT3A, 5A, and 10B via CD442019
- Author(s)
  Takahashi H, Ogoyama M, Nagayama S, Suzuki H, Ohkuchi A, Matsubara S, Takizawa T
- Journal Title
  
  The Journal of Maternal-Fetal & Neonatal Medicine
  
  Volume: 印刷中 Issue: 20 Pages: 1-9
- DOI
  10.1080/14767058.2019.1684891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18650, KAKENHI-PROJECT-17K11256
[Journal Article] Oxygen concentration modulates cellular senescence and autophagy in human trophoblast cells2018
- Author(s)
  Seno K, Tanikawa N, Takahashi H, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T, Shirasuna K
- Journal Title
  
  Am J Reprod Immunol
  
  Volume: 79 Issue: 6
- DOI
  10.1111/aji.12826
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07783, KAKENHI-PROJECT-16K11103, KAKENHI-PROJECT-26462498
[Journal Article] Endogenous and exogenous miR-520c-3p modulates CD44-mediated extravillous trophoblast invasion2017
- Author(s)
  Takahashi H, Ohkuchi A, Kuwata T, Usui R, Baba Y, Suzuki H, Chaw Kyi TT, Matsubara S, Saito S, Takizawa T
- Journal Title
  
  Placenta
  
  Volume: 50 Pages: 25-31
- DOI
  10.1016/j.placenta.2016.12.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04980, KAKENHI-PROJECT-24592482, KAKENHI-PROJECT-16K11103
[Presentation] 胎盤栄養膜細胞株（BeWo）由来細胞外粒子の解析2023
- Author(s)
  野口隼矢，斗澤昇平，櫻井孝信，高橋宏典，大口昭英，藤原寛行，瀧澤俊広
- Organizer
  第128回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-20K09611
[Presentation] The regulatory mechanism of extravillous trophoblast invasion through microRNAs2023
- Author(s)
  Hironori Takahashi
- Organizer
  アジア生殖免疫学会(Asian congress for reproductive immunology)
- Invited
- Data Source
  KAKENHI-PROJECT-19K18650
[Presentation] The regulatory mechanism of extravillous trophoblast invasion through microRNAs2023
- Author(s)
  Hironori Takahashi
- Organizer
  1st Asian Congress for Reprodutive Immunology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09624
[Presentation] 胎盤栄養膜細胞株BeWo由来ナノ粒子の形態・構成蛋白質解析2022
- Author(s)
  野口隼矢, 斗澤昇平, 櫻井孝信, 大口昭英, 高橋宏典, 藤原寛行, 瀧澤俊広
- Organizer
  第127回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-20K09611
[Presentation] 胎盤栄養膜細胞株 BeWo 由来ナノ粒子の形態・構成蛋白質解析　WEB開催（オンデマンド配信）2022
- Author(s)
  野口隼矢，斗澤昇平，櫻井孝信，大口昭英，高橋宏典，藤原寛行，瀧澤俊広
- Organizer
  第127回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-20K09611
[Presentation] 栄養膜細胞株BeWo細胞から分泌されるエクソソームとナノ粒子の比較解析2022
- Author(s)
  斗澤昇平，野口隼矢，櫻井孝信，高橋宏典，大口昭英，藤原寛行，瀧澤俊広
- Organizer
  第30回日本胎盤学会学術集会・第40回日本絨毛性疾患研究会
- Data Source
  KAKENHI-PROJECT-20K09611
[Presentation] 栄養膜細胞から分泌されるナノ粒子の同定：BeWo細胞を用いた解析2022
- Author(s)
  斗澤昇平，野口隼矢，櫻井孝信，大口昭英，高橋宏典，藤原寛行，瀧澤俊広
- Organizer
  第74回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K09611
[Presentation] 栄養膜細胞株BeWo細胞から分泌されるナノ粒子の特徴付け2022
- Author(s)
  斗澤昇平，野口隼矢，櫻井孝信，大口昭英，高橋宏典，藤原寛行，瀧澤俊広
- Organizer
  第37回日本生殖免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K09611
[Presentation] 胎盤絨毛栄養膜細胞miRNA生合成酵素DROSHAの局在2021
- Author(s)
  瀧澤俊広, 小古山学, 高橋宏典, 大口昭英
- Organizer
  第36回日本生殖免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K09611
[Presentation] 絨毛外栄養膜細胞に高発現しているmiR-675-5pは転写調節因子GATA2の抑制を介してMMP13/MMP14の発現を上昇させ細胞浸潤を促進する2021
- Author(s)
  小古山学, 大口昭英, 高橋宏典, 松原茂樹, 瀧澤俊広
- Organizer
  第73回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K09611
[Presentation] Non-coding RNAs in extravillous trophoblast cells. (Symposium 4: Prediction & Prevention of PE)2021
- Author(s)
  Toshihiro Takizawa, Manabu Ogoyama, Hironori Takahashi, Akihide Ohkuchi
- Organizer
  The 22nd World Congress of International Society for the Study of Hypertension in Pregnancy, ISSHP 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09611
[Presentation] ヒト満期胎盤絨毛における細胞性栄養膜細胞層の3次元構造解析2021
- Author(s)
  櫻井孝信, 菅潮里, 島田春貴, 高橋宏典, 大口昭英, 瀧澤俊広
- Organizer
  第29回日本胎盤学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09611
[Presentation] ヒト胎盤高発現lncRNAの妊娠高血圧腎症胎盤における発現解析2020
- Author(s)
  小古山　学、王　じゅん曉、趙　東威、高橋　宏典、松原　茂樹、大口　昭英、瀧澤　俊広
- Organizer
  第28回日本胎盤学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09611
[Presentation] 胎盤絨毛栄養膜細胞のmiRNA生合成酵素DROSHAは従来にない遺伝子発現を調節する機能を有している2020
- Author(s)
  瀧澤俊広、高橋宏典、小古山学、大口昭英、竹下俊行、松原茂樹
- Organizer
  第72回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K09611
[Presentation] miR-675-5pは複数のmatrix metalloproteinaseの発現を上昇させ絨毛外栄養膜細胞の浸潤を促進する2020
- Author(s)
  小古山学、大口昭英、高橋宏典、松原茂樹、瀧澤俊広
- Organizer
  第35回日本生殖免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18650
[Presentation] miR-675-5pは複数のmatrix metalloproteinaseの発現を上昇させ絨毛外栄養膜細胞の浸潤を促進する2020
- Author(s)
  小古山　学、大口　昭英、高橋　宏典、松原　茂樹、瀧澤　俊広
- Organizer
  第35回日本生殖免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K09611
[Presentation] Long non-coding RNA H19由来のmiR-675-5pは転写調節因子GATA2を介して絨毛外栄養膜細胞の浸潤を促進する2020
- Author(s)
  小古山学、大口昭英、高橋宏典、松原茂樹、瀧澤俊広
- Organizer
  第72回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K09611
[Presentation] Potential role of exosomal placenta-associated microRNA for extravillous trophoblast2018
- Author(s)
  Hironori Takahashi
- Organizer
  International Federation of Placenta Associations (IFPA)2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11103
[Presentation] WNT10Bによる絨毛外栄養膜の浸潤促進2018
- Author(s)
  高橋宏典
- Organizer
  生殖免疫学会
- Data Source
  KAKENHI-PROJECT-16K11103
[Presentation] WNT10BによるCD44を介した絨毛外栄養膜の浸潤促進2018
- Author(s)
  高橋宏典、小古山学、大口昭英、瀧澤俊広、松原茂樹
- Organizer
  第70回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-16K11103
[Presentation] Change in microRNA expression in preeclamptic maternal blood: Sixty microRNA detected by microarray analysis (3D-Gene chip) with global normalization2017
- Author(s)
  Hironori Takahashi, Manabu Ogoyama, Shiho Nagayama, Yoichi Ishida, Yosuke Baba, Tomoyuki Kuwata, Rie Usui, Toshihiro Takizawa, Akihide Ohkuchi, Shigeki Matsubara
- Organizer
  第69回日本産科婦人科学会学術講演会
- Place of Presentation
  広島グリーンアリーナ(広島市)
- Year and Date
  2017-04-15
- Data Source
  KAKENHI-PROJECT-16K11103

1. 大口昭英 (10306136)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
2. 瀧澤俊広 (90271220)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
3. 根岸靖幸 (50644580)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 白砂孔明 (20552780)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 小古山学 (60741692)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 石田洋一 (70772143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 大倉定之 (10731036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 江川真希子 (00644212)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 神田英一郎 (40401377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 宮坂尚幸 (70313252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 吉田雅幸 (80282771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 鈴木寛正 (90406116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 永山志穂 (80741694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 野口隼矢 (30879698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 岩田尚孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 桑山岳人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 斎藤滋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Hironori 高橋 宏典

Research Projects

Research Products

Co-Researchers

胎盤由来細胞間輸送体の新パラダイムによる妊娠高血圧腎症・早産の病態解明と発症予知

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

妊娠期におけるサルコペニア肥満の臨床的意義に関する研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel prediction of placenta accreta spectrum using circulating microRNA in in the first trimesterPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

胎盤由来エクソソームによる妊娠高血圧腎症の予知法に関する研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the novel function of trophoblast DROSHA as a novel therapeutic strategy for preventing congenital viral infection

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

妊娠初期における超早産バイオマーカー探索:エクソソーム中胎盤特異的miRNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The comprehensive microRNA analysis and an etiologic study for early-onset preeclampsiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Elevated S100A9 in preeclampsia induces soluble endoglin and IL-1b secretion and hypertension via the NLRP3 inflammasome.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Non-coding RNAs and prediction of preeclampsia in the first trimester of pregnancy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LncRNA H19-derived miR-675-5p accelerates the invasion of extravillous trophoblast cells by inhibiting GATA2 and subsequently activating matrix metalloproteinases2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] β-hydroxybutyrate suppresses NLRP3 inflammasome-mediated placental inflammation and lipopolysaccharide-induced fetal absorption.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extravillous trophoblast invasion accelerated by WNT3A, 5A, and 10B via CD442019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oxygen concentration modulates cellular senescence and autophagy in human trophoblast cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endogenous and exogenous miR-520c-3p modulates CD44-mediated extravillous trophoblast invasion2017

Author(s)

Journal Title

DOI

Takahashi Hironori 高橋宏典

[Presentation] 胎盤栄養膜細胞株 BeWo 由来ナノ粒子の形態・構成蛋白質解析　WEB開催（オンデマンド配信）2022

[Presentation] 胎盤絨毛栄養膜細胞のmiRNA生合成酵素DROSHAは従来にない遺伝子発現を調節する機能を有している2020