MIZOBUCHI Yoshifumi 溝渕佳史

Researcher Number	80547993
Affiliation (based on the past Project Information) *help	2015: 徳島大学, 大学病院, 講師 2013: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 2011 – 2013: 徳島大学, ヘルスバイオサイエンス研究部, 助教 2010 – 2011: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教
Review Section/Research Field	Principal Investigator Neurosurgery / Cerebral neurosurgery Except Principal Investigator Cerebral neurosurgery
Keywords	Principal Investigator 遺伝子治療 / Wntシグナル / 脳腫瘍 / Ad-REIC / 悪性脳腫瘍 / ｸﾞﾘｵﾌﾞﾗｽﾄｰﾏ / DKK3 / Wnt / グリオブラストーマ / REIC-DKK-3 / REIC-Dkk3 … More Except Principal Investigator … More Wnt シグナル / glioblastoma / アポトーシス / REIC/Dkk-3 / 薬物排出ポンプ / Wntシグナル / REIC / 脳腫瘍 Less

Anti-tumor effects and Regulation of Wnt signaling pathway of adenovirus-mediated DKK3 in glioblastomaPrincipal Investigator
- Principal Investigator
  
  MIZOBUCHI Yoshifumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  The University of Tokushima
A new therapeutic strategy using adenovirus vector REIC gene in a new glioblastoma (GBM) mice model
- Principal Investigator
  
  KAGEJI Teruyoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  The University of Tokushima
Mechanisms underlying regulation of Wnt signaling pathway against cancer stem-and glioma cellsPrincipal Investigator
- Principal Investigator
  
  MIZOBUCHI Yoshifumi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  The University of Tokushima

All 2015 2014 2013 2012 2011

All Journal Article Presentation

[Journal Article] Diagnosis of brain tumors using dynamic contrast-enhanced perfusion imaging with a short acquisition time2015
- Author(s)
  Abe T, Mizobuchi Y, Nakajima K, Otomi Y, Irahara S, Obama Y, Majigsuren M, Khashbat D, Kageji T, Nagahiro S, Harada M
- Journal Title
  
  Springerplus
  
  Volume: 4 Issue: 1 Pages: 88-88
- DOI
  10.1186/s40064-015-0861-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462264, KAKENHI-PROJECT-26861153
[Journal Article] Blocking of the interaction between Wnt proteins and their co-receptors contributes to the anti-tumor effects of adenovirus-mediated DKK3 in glioblastoma2015
- Author(s)
  Hara K, Kageji T, Mizobuchi Y, Kitazato KT, Okazaki T, Fujihara T, Nakajima K, Mure H, Kuwayama K, Hara T, Nagahiro S
- Journal Title
  
  Cancer Lett
  
  Volume: 356 Issue: 2 Pages: 496-505
- DOI
  10.1016/j.canlet.2014.09.045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462264, KAKENHI-PROJECT-26861153
[Journal Article] Correlation between radiation dose and histopathological findings in patients with gliblastoma treated with boron neutron capture therapy (BNCT)2014
- Author(s)
  Kageji T, Mizobuchi Y, Nagahiro S, Nakagawa Y, Kumada H
- Journal Title
  
  Appl Radiat Isot
  
  Volume: 88 Pages: 20-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592128
[Journal Article] Nine-year interval recurrence after treatment of boron neutron capture therapy in a patient with glioblastoma2014
- Author(s)
  Okazaki T, Kageji T, Mizobuchi Y, Miyamoto T, Nagahiro S
- Journal Title
  
  A case report. Appl Radiat Isot
  
  Volume: 88 Pages: 28-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592128
[Journal Article] Nine-year interval recurrence after treatment of boron neutron capture therapy in a patient with glioblastoma: A case report2014
- Author(s)
  Toshiyuki Okazaki, Teruyoshi Kageji, Yoshifumi Mizobuchi, Takeshi Miyamoto, Shinji Nagahiro
- Journal Title
  
  Appl Radiat Isot
  
  Volume: S0969-8043(13) Pages: 629-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592128
[Journal Article] Anaplastic astroblastomaの鑑別診断と治療　ー症例報告と文献的考察ー2013
- Author(s)
  倉敷佳孝、影治照喜、溝渕佳史、里見淳一郎、佐藤浩一、廣瀬隆則、永廣信治
- Journal Title
  
  脳神経外科
  
  Volume: 41 Pages: 891-899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592128
[Journal Article] Differential diagnosis of and therapy for anaplastic astroblastoma : case report and review of the literature]2013
- Author(s)
  Kurashiki Y, Kageji T, Mizobuchi Y, Satomi J, Satoh K, Hirose T, Nagahiro S
- Journal Title
  
  No Shinkei Geka
  
  Volume: 41 Pages: 891-899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592128
[Journal Article] Correlation between radiation dose and histopathological findings in patients with gliblastoma treated with boron neutron capture therapy (BNCT)2013
- Author(s)
  Kageji T, T. Kageji, Y. Mizobuchi, S. Nagahiro, Y. Nakagawa, H. Kumada
- Journal Title
  
  Appl Radiat Isot
  
  Volume: S0969-8043(13) Pages: 610-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592128
[Journal Article] Practical management of botulinum toxin therapy2011
- Author(s)
  Lim EC, Bhidayasiri R, Rosales RL, Kaji R.
- Journal Title
  
  Introduction. Parkinsonism & related disorders
  
  Volume: 17 Issue: 2 Pages: 123-5
- DOI
  10.1016/j.parkreldis.2010.11.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390269, KAKENHI-PROJECT-22791348, KAKENHI-PROJECT-23500428
[Journal Article] Clinical results of boron neutron capture therapy(BNCT) for glioblastoma2011
- Author(s)
  Kageji T, Mizobuchi Y, Nagahiro S, Nakagawa Y, Kumada H
- Journal Title
  
  Appl Radiat Isot
  
  Volume: 69 Issue: 12 Pages: 1823-5
- DOI
  10.1016/j.apradiso.2011.05.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791348
[Journal Article] Severe head injuries during Judo practice]2011
- Author(s)
  Nagahiro S, Mizobuchi Y, Hondo H, Kasuya H, Kamitani T, Shinbara Y, Nimura Y, Tomatsu T.
- Journal Title
  
  No Shinkei Geka
  
  Volume: 39 Pages: 1139-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791348
[Journal Article] Long-survivors of glioblatoma treated with boron neutron capture therapy(BNCT)2011
- Author(s)
  Kageji T, Mizobuchi Y, Nagahiro S, Nakagawa Y, Kumada H
- Journal Title
  
  Appl Radiat Isot
  
  Volume: 69 Issue: 12 Pages: 1800-2
- DOI
  10.1016/j.apradiso.2011.03.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791348
[Presentation] Intensive chemotherapy followed by reduced radiation dose for intracranial non-germinomatous germ cell tumors2015
- Author(s)
  T.Kageji, Y.Mizobuchi, K.Nakajima, S.Nagahiro, H.Watanabe, N.Inoue, K.Okamura, S.Kagami
- Organizer
  20th Annual Socientific Meeting and Education Day of the Society for Neuro-Oncology
- Place of Presentation
  Texas, USA
- Year and Date
  2015-11-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462264
[Presentation] Intensive chemotherapy followed by reduced radiation dose for intracranial non-germinomatous germ cell tumors2015
- Author(s)
  T. Kageji, Y. Mizobuchi, K. Nakajima, S. Nagahiro, H. Watanabe, N. Inoue, K. Okamura, S. Kagami
- Organizer
  13th Congress of the World Federatoin of Interventional and Therapeutic Neuroradiology
- Place of Presentation
  Gold Coast, Australia
- Year and Date
  2015-11-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462264
[Presentation] Down-regulation of MDR1 by DKK3 attenuates chemoresistance to temozolomide, and potentiates its anti-tumor effects2015
- Author(s)
  T.Fujihara, T.Kageji, Y.Mizobuchi, R.Otsuka K.Kitazato, K.Hara, K.Shono, K.Nakajima H.Mure, K.Kuwayama, S.Nagahiro
- Organizer
  20th Annual Socientific Meeting and Education Day of the Society for Neuro-Oncology
- Place of Presentation
  Texas, USA
- Year and Date
  2015-11-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462264
[Presentation] Sonodynamic 5-ALA plus ultrasound therapy augments anti-tumor effects in the oncogene knock-in glioma stemcells2015
- Author(s)
  K.Shono, T.Kageji, Y.Mizobuchi, T.Fujihara, K.Kitazato, K.Nakajima, H.Mure, K.Kuwayama, S.Nagahiro
- Organizer
  20th Annual Socientific Meeting and Education Day of the Society for Neuro-Oncology,
- Place of Presentation
  Texas,USA
- Year and Date
  2015-11-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462264
[Presentation] Intensive Chemotherapy Followed by Reduced Dose Radiation for Intracranial Non-germinomatous Germ Cell Tumors2015
- Author(s)
  H.Watanabe, N.Inoue, K.Okamura, S.Nagahiro, Y.Mizobuchi, K.Nakajima,T.Kageji, S.Kagami
- Organizer
  The 4th International CNS Germ Cell Tumor Symposium
- Place of Presentation
  HAPPO-EN,Tokyo, minato-ku
- Year and Date
  2015-04-12
- Data Source
  KAKENHI-PROJECT-25462264
[Presentation] Strategy and Clinical Results for Intracranial Non-germinomatous Germ Cell Tumors Induced Intensive Chemotherapy2015
- Author(s)
  T.Kageji, Y.Mizobuchi, K.Nakajima, S.Nagahiro H.Watanabe, N.Inoue, K.Okamura, S.Kagami
- Organizer
  The 4th International CNS Germ Cell Tumor Symposium
- Place of Presentation
  HAPPO-EN,Tokyo, minato-ku
- Year and Date
  2015-04-12
- Data Source
  KAKENHI-PROJECT-25462264
[Presentation] Down-regulation of MDR by Ad-Dkk3 contributes to augment the chemotherapy by temozolomide2013
- Author(s)
  K.Nakajima, K.Hara, T.Kageji, Y.Mizobuchi, K.T.Kitazato, T.Fujihara, K.Kuwayama, R.Otsuka, D K.Kung, S.Nagahiro
- Organizer
  SNO 2013
- Place of Presentation
  Marriott Maquis Hotel (San Francisco, USA)
- Data Source
  KAKENHI-PROJECT-23592128
[Presentation] Dkk-3, one of Dickkopf (Dkk) family members, contributes to the anti-tumor effects in glioblastoma through regulation of both Wnt signal pathways2013
- Author(s)
  K.Hara, T.Kageji, Y.Mizobuchi, K.T.Kitazato, T.Okazaki, T.Fujihara, K.Nakajima, H.Mure, K.Kuwayama, T.Hara, S.Nagahiro
- Organizer
  SNO 2013
- Place of Presentation
  Marriott Maquis Hotel (San Francisco, USA)
- Data Source
  KAKENHI-PROJECT-23592128
[Presentation] A combination of interferon-b and temozolomide augments anti-tumor effects through p73/YAP-mediated apoptosis by PML in glioblastoma2013
- Author(s)
  Y.Mizobuchi, T.Okazaki, T.Kageji, K.Kuwayama, K.T.Kitazato, H.Mure, K.Hara, R.Morigaki, K.Matsuzaki, K.Nakajima, T.Fujihara, S.Nagahiro
- Organizer
  SNO 2013
- Place of Presentation
  Marriott Marquis Hotel (San Francisco, USA)
- Data Source
  KAKENHI-PROJECT-25462264
[Presentation] A combination of interferon-b and temozolomide augments anti-tumor effects through p73/YAP-mediated apoptosis by PML in glioblastoma2013
- Author(s)
  Mizobuchi Y, Okazaki T, Kageji T, Kuwayama K, Kitazato KT, Mure H, Hara K, Morigaki R, Matsuzaki K, Nakajima K, Fujihara T, Nagahiro S
- Organizer
  SNO 2013
- Place of Presentation
  Moscone West Convention Center (San Francisco, USA)
- Data Source
  KAKENHI-PROJECT-23592128
[Presentation] Dkk-3, one of Dickkopf (Dkk) family members2013
- Author(s)
  Hara K, Kageji T, Mizobuchi Y, Kitazato KT, Okazaki T, Fujihara T, Nakajima K, Mure H, Kuwayama K, Hara K, Nagahiro S
- Organizer
  contributes to the anti-tumor effects in glioblastoma through regulation of both Wnt signal pathways SNO 2013
- Place of Presentation
  Moscone West Convention Center (San Francisco, USA)
- Data Source
  KAKENHI-PROJECT-23592128
[Presentation] Down- regulation of MDR by Ad-Dkk3 contri- butes to augment the chemotherapy by temozolomide2013
- Author(s)
  Nakajima K, Hara K, Kageji T, Mizobuchi Y, Kitazato KT, Fujihara T, Kuwayama K, Otsuka R, Kung DK, Nagahiro S
- Organizer
  SNO 2013
- Place of Presentation
  Moscone West Convention Center (San Francisco, USA)
- Data Source
  KAKENHI-PROJECT-23592128
[Presentation] Down-regulation of MDR by Ad-Dkk3 contributes to augment the chemotherapy by temozolomide2013
- Author(s)
  K.Nakajima, K.Hara, T.Kageji, Y.Mizobuchi, K.T.Kitazato, T.Fujihara, K.Kuwayama, R.Otsuka, D K.Kung, S.Nagahiro
- Organizer
  SNO 2013
- Place of Presentation
  Marriott Marquis Hotel (San Francisco, USA)
- Data Source
  KAKENHI-PROJECT-25462264
[Presentation] Dkk-3, one of Dickkopf (Dkk) family members, contributes to the anti-tumor effects in glioblastoma through regulation of both Wnt signal pathways2013
- Author(s)
  K.Hara, T.Kageji, Y.Mizobuchi, K.T.Kitazato, T.Okazaki, T.Fujihara, K.Nakajima, H.Mure, K.Kuwayama, T.Hara, S.Nagahiro
- Organizer
  SNO 2013
- Place of Presentation
  Marriott Marquis Hotel (San Francisco, USA)
- Data Source
  KAKENHI-PROJECT-25462264
[Presentation] A combination of interferon-b and temozolomide augments anti-tumor effects through p73/YAP-mediated apoptosis by PML in glioblastoma2013
- Author(s)
  Y.Mizobuchi, T.Okazaki, T.Kageji, K.Kuwayama, K.T.Kitazato, H.Mure, K.Hara, R.Morigaki, K.Matsuzaki, K.Nakajima, T.Fujihara, S.Nagahiro
- Organizer
  SNO 2013
- Place of Presentation
  Marriott Maquis Hotel (San Francisco, USA)
- Data Source
  KAKENHI-PROJECT-23592128
[Presentation] REIC/Dkk-3 gene and protein regulate medulloblastoma cell growth2012
- Author(s)
  Mizobuchi Y, et al
- Organizer
  AANS 2012
- Place of Presentation
  Miami, USA
- Year and Date
  2012-04-15
- Data Source
  KAKENHI-PROJECT-22791348
[Presentation] 悪性神経膠腫におけるREIC/Dkk-3遺伝子導入によるWnt蛋白制御の意義2012
- Author(s)
  原慶次郎、溝渕佳史、北里慶子、岡﨑敏之、影治照喜、永廣信治、公文裕巳
- Organizer
  第13回日本分子脳神経外科学会
- Place of Presentation
  熊本市国際交流会館(熊本県熊本市)
- Data Source
  KAKENHI-PROJECT-23592128

1. KAGEJI Teruyoshi (70294684)

# of Collaborated Projects: 2 results

# of Collaborated Products: 24 results
2. NAGAHIRO Shinji (60145315)

# of Collaborated Projects: 2 results

# of Collaborated Products: 24 results
3. MURE Hideo (00624355)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
4. KURASHIKI Yoshitaka (10597503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. KUWAYAMA Kazuyuki (50614236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. NAKAJIMA Kohei (40710554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
7. HARA Keijirou (60710340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. 梶龍兒

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIZOBUCHI Yoshifumi 溝渕 佳史

Research Projects

Research Products

Co-Researchers

Anti-tumor effects and Regulation of Wnt signaling pathway of adenovirus-mediated DKK3 in glioblastomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A new therapeutic strategy using adenovirus vector REIC gene in a new glioblastoma (GBM) mice model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms underlying regulation of Wnt signaling pathway against cancer stem-and glioma cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Diagnosis of brain tumors using dynamic contrast-enhanced perfusion imaging with a short acquisition time2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Blocking of the interaction between Wnt proteins and their co-receptors contributes to the anti-tumor effects of adenovirus-mediated DKK3 in glioblastoma2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Correlation between radiation dose and histopathological findings in patients with gliblastoma treated with boron neutron capture therapy (BNCT)2014

Author(s)

Journal Title

Data Source

[Journal Article] Nine-year interval recurrence after treatment of boron neutron capture therapy in a patient with glioblastoma2014

Author(s)

Journal Title

Data Source

[Journal Article] Nine-year interval recurrence after treatment of boron neutron capture therapy in a patient with glioblastoma: A case report2014

Author(s)

Journal Title

Data Source

[Journal Article] Anaplastic astroblastomaの鑑別診断と治療 ー症例報告と文献的考察ー2013

Author(s)

Journal Title

Data Source

[Journal Article] Differential diagnosis of and therapy for anaplastic astroblastoma : case report and review of the literature]2013

Author(s)

Journal Title

Data Source

[Journal Article] Correlation between radiation dose and histopathological findings in patients with gliblastoma treated with boron neutron capture therapy (BNCT)2013

Author(s)

Journal Title

Data Source

[Journal Article] Practical management of botulinum toxin therapy2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical results of boron neutron capture therapy(BNCT) for glioblastoma2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Severe head injuries during Judo practice]2011

Author(s)

Journal Title

Data Source

[Journal Article] Long-survivors of glioblatoma treated with boron neutron capture therapy(BNCT)2011

Author(s)

Journal Title

DOI

Data Source

[Presentation] Intensive chemotherapy followed by reduced radiation dose for intracranial non-germinomatous germ cell tumors2015

Author(s)

Organizer

Place of Presentation

Year and Date

MIZOBUCHI Yoshifumi 溝渕佳史

[Journal Article] Anaplastic astroblastomaの鑑別診断と治療　ー症例報告と文献的考察ー2013