Ouhara Kazuhisa 應原一久

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OUHARA Kazuhisa 應原一久

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Researcher Number	80550425
Other IDs	https://orcid.org/0000-0001-6796-884X
Affiliation (Current)	2025: 広島大学, 医系科学研究科(歯), 助教
Affiliation (based on the past Project Information) *help	2025: 広島大学, 医系科学研究科(歯), 助教 2019 – 2023: 広島大学, 医系科学研究科(歯), 助教 2017 – 2018: 広島大学, 医歯薬保健学研究科(歯), 助教 2013 – 2016: 広島大学, 医歯薬保健学研究院(歯), 助教 2015: 広島大学, 大学院医歯薬保健学研究院, 助教 … More 2014 – 2015: 広島大学, 医歯薬保健学研究院, 助教 2014: 広島大学, 大学院医歯薬保健学研究院(歯), 助教 2012: 広島大学, 医歯薬保健学研究院, 助教 2012: 広島大学, 大学院・医歯薬保健学研究院, 助教 2009 – 2011: Hiroshima University, 大学院・医歯薬学総合研究科, 助教 2010: Hiroshima University, 医歯(薬)学総合研究科, 助教 Less
Review Section/Research Field	Principal Investigator Basic Section 57030:Conservative dentistry-related / Periodontology / Periodontal dentistry Except Principal Investigator Basic Section 57030:Conservative dentistry-related / Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 57020:Oral pathobiological science-related / Periodontology / Conservative dentistry / Periodontal dentistry
Keywords	Principal Investigator 歯周炎 / 関節リウマチ / 歯周病原細菌 / 抗体 / 能動輸送 / 歯肉上皮細胞 / 歯周炎モデルマウス / Porphyromonas gingivalis / 歯周病 / 自己抗体 … More / ACPA / IL-6 / マウス / RNA binding protein / RNA安定化タンパク質 / シトルリン化タンパク質 / ケルセチン / 歯周病源細菌 / RNA結合タンパク質 / LRG1 / サイトカイン / リウマチ / IgG / Ig / FcRn … More Except Principal Investigator 関節リウマチ / 歯周炎 / 侵襲性歯周炎 / 歯周病 / Porphyromonas gingivalis / 全身疾患 / 唾液 / LAMP法 / 破骨細胞 / 創薬研究 / DELスクリーニング / iPS細胞 / MMD2 / 予後予測 / ACPA / 迅速診断 / F. n. / A. a. / 口腔細菌 / 神経炎症 / 認知症 / 認知機能障害 / ミクログリア / 肥満 / 健康寿命の延伸 / セロタイプ / PRIP / 脳出血 / Cnm陽性う蝕原因細菌 / モノクローナルACPA / N-結合型糖鎖 / 抗シトルリン化タンパク質抗体 / 心線維化 / 心筋線維化 / ビッグデータ解析 / 歯周病原細菌 / ジンジパイン / 心房線維化 / 心房細動 / 歯性感染病巣 / 歯周医学 / 迅速検出法 / 口腔細菌遺伝子 / cnm / 口腔検査 / fimA / Streprococcus mutans / 迅速検出 / 口腔内細菌 / 迅速検査 / cnm遺伝子 / ＳＫＧマウス / 抗シトルリン化ペプチド抗体 / CXCL10 / 滑膜細胞 / LPS / シトルリン化フィブリノーゲン / モノクローナル抗体 / SKGマウス / 抗シトルリン化蛋白抗体 / バクテレミア / 腸内細菌叢 / バクテリミア / 糖最終産物の受容体 / 根尖性歯周炎 / 歯髄炎 / 歯内病変 / 歯髄由来繊維芽細胞 / RAGE / 好中球 / 歯内疾患 / 糖尿病 / セメント質形成 / マイクロRNA / マイクロＲＮＡ / 歯周組織再生 / 歯周靭帯細胞 / セメント芽細胞 / 間葉系幹細胞 Less

Classification of the clinical significance of autoantibodies in rheumatoid arthritis patients and development of a prognosis prediction method based on this
- Principal Investigator
  
  小澤龍彦
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  University of Toyama
Search for novel specific molecular targets for aggressive periodontitis patients with MMD2 mutations
- Principal Investigator
  
  水野智仁
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
DNA-Encoded Libraryを活用したNR4A1を標的とする新規歯周炎治療薬の創薬研究
- Principal Investigator
  
  松田真司
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
Elucidation of the Inhibitory Mechanism of Periodontal Tissue Destruction against Antigens from Periodontopathogenic Bacteria Using Antibody Modification TechnologyPrincipal Investigator
- Principal Investigator
  
  應原一久
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
Elucidating the mechanisms of interaction between obesity pathology and periodontal infection on cognitive function
- Principal Investigator
  
  大植香菜
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
Development of a rapid diagnostic kit for oral bacteria associated with systemic disease using saliva
- Principal Investigator
  
  北川雅恵
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
Elucidation of the mechanism of periodontal tissue destruction by ACPA derived from patients with rheumatoid arthritis and periodontopathogenic bacteria-related proteinsPrincipal Investigator
- Principal Investigator
  
  應原一久
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
侵襲性歯周炎の新規責任遺伝子の同定と病態解析
- Principal Investigator
  
  水野智仁
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
Comprehensive study on the effects of periodontal pathogen on the pathophysiology of atrial fibrillation
- Principal Investigator
  
  Miyauchi Mutsumi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Hiroshima University
Elucidation of the pathological mechanism of rheumatoid arthritis induced by N-linked glycans in the ACPA variable region
- Principal Investigator
  
  Ozawa Tatsuhiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  University of Toyama
Elucidation of the mechanism of cerebral hemorrhage aggravation via PRIP by Cnm-positive cariogenic bacteria to extend healthy life span
- Principal Investigator
  
  Shiba Hideki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
Establishment of rapid detection method for oral bacterial genes associated with systemic diseases
- Principal Investigator
  
  Kitagawa Masae
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
Development of inhibitors of osteoclast differentiation with an anti-citrullinated protein monoclonal antibody
- Principal Investigator
  
  SUGIYAMA EIJI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Hiroshima University
The induced RNA-binding protein, HuR targets of IL-6 mRNA and enhances its stabilization in periodontitisPrincipal Investigator
- Principal Investigator
  
  Ouhara Kazuhisa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
The bidirectional effect of Leucine-rich alpha-2-glycoprotein 1 (LRG1) in rheumatoid arthritis and periodontitisPrincipal Investigator
- Principal Investigator
  
  Ouhara Kazuhisa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Hiroshima University
The basic research for the prevention of periodontitis induced bacterimia by using probiotics
- Principal Investigator
  
  Kurihara Hidemi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Periodontology
- Research Institution
  Hiroshima University
Elucidate the mechanism of aggravation of endodontic disease on diabetic patients
- Principal Investigator
  
  Uchida Yushi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Hiroshima University
The effect of PAD derived from periodontopathogenic bacteria in rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  OUHARA Kazuhisa
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontology
- Research Institution
  Hiroshima University
Induction of cementoblastic differentiation from mesenchymal stem cells and cementogenesis on dentin surface
- Principal Investigator
  
  KURIHARA HIDEMI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Hiroshima University
The analysis and application for periodontal treatment of FcRn which is tha passive IgG transporter in epithelial cellsPrincipal Investigator
- Principal Investigator
  
  OUHARA Kazuhisa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Hiroshima University
上皮細胞が産生するIgG能動輸送タンパク質FcRnによる歯周炎治療法の開発Principal Investigator
- Principal Investigator
  
  應原一久
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Periodontal dentistry
- Research Institution
  Hiroshima University

[Journal Article] Periostin regulates integrin expression in gingival epithelial cells2024
- Author(s)
  Hirata Reika、Iwata Tomoyuki、Fujita Tsuyoshi、Nagahara Takayoshi、Matsuda Shinji、Sasaki Shinya、Taniguchi Yuri、Hamamoto Yuta、Ouhara Kazuhisa、Kudo Yasusei、Kurihara Hidemi、Mizuno Noriyoshi
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: 66 Issue: 1 Pages: 170-178
- DOI
  10.1016/j.job.2023.11.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09983
[Journal Article] Periodontal tissue regeneration with cementogenesis after application of brain‐derived neurotrophic factor in 3‐wall inflamed intra‐bony defect2024
- Author(s)
  Kiyota Mari、Iwata Tomoyuki、Hasegawa Naohiko、Sasaki Shinya、Taniguchi Yuri、Hamamoto Yuta、Matsuda Shinji、Ouhara Kazuhisa、Takeda Katsuhiro、Fujita Tsuyoshi、Kurihara Hidemi、Kawaguchi Hiroyuki、Mizuno Noriyoshi
- Journal Title
  
  Journal of Periodontal Research
  
  Volume: - Issue: 3 Pages: 530-541
- DOI
  10.1111/jre.13244
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09983
[Journal Article] Predictive factors of periodontal regeneration outcomes using rhFGF‐2: A case control study2024
- Author(s)
  Matsuda Shinji、Ueda Tomoya、Nakashima Fuminori、Ninomiya Yurika、Yasuda Keisuke、Sasaki Shinya、Hamamoto Yuta、Iwata Tomoyuki、Ouhara Kazuhisa、Mihara Naoki、Kakimoto Naoya、Mizuno Noriyoshi
- Journal Title
  
  Journal of Periodontal Research
  
  Volume: - Issue: 4 Pages: 679-688
- DOI
  10.1111/jre.13259
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09983
[Journal Article] A Cartilaginous Construct with Bone Collar Exerts Bone-Regenerative Property Via Rapid Endochondral Ossification2023
- Author(s)
  Morimoto Shin、Kajiya Mikihito、Yoshii Hiroki、Yoshino Mai、Horikoshi Susumu、Motoike Souta、Iwata Tomoyuki、Ouhara Kazuhisa、Ando Toshinori、Yoshimoto Tetsuya、Shintani Tomoaki、Mizuno Noriyoshi
- Journal Title
  
  Stem Cell Reviews and Reports
  
  Volume: 19 Issue: 6 Pages: 1812-1827
- DOI
  10.1007/s12015-023-10554-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09983, KAKENHI-PROJECT-22K17060, KAKENHI-PROJECT-23K24533, KAKENHI-PROJECT-21K16993
[Journal Article] In Situ Raman Analysis of Biofilm Exopolysaccharides Formed in Streptococcus mutans and Streptococcus sanguinis Commensal Cultures2023
- Author(s)
  Pezzotti Giuseppe、Ofuji Satomi、Imamura Hayata、Adachi Tetsuya、Yamamoto Toshiro、Kanamura Narisato、Ohgitani Eriko、Marin Elia、Zhu Wenliang、Mazda Osam、Togo Azusa、Kimura Satoshi、Iwata Tadahisa、Shiba Hideki、Ouhara Kazuhisa、Aoki Takashi、Kawai Toshihisa
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 7 Pages: 6694-6694
- DOI
  10.3390/ijms24076694
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09983, KAKENHI-PROJECT-23K09196
[Journal Article] Mechanosignaling YAP/TAZ-TEAD Axis Regulates the Immunomodulatory Properties of Mesenchymal Stem Cells2023
- Author(s)
  Yoshii Hiroki、Kajiya Mikihito、Yoshino Mai、Morimoto Shin、Horikoshi Susumu、Tari Misako、Motoike Souta、Iwata Tomoyuki、Ouhara Kazuhisa、Ando Toshinori、Yoshimoto Tetsuya、Shintani Tomoaki、Mizuno Noriyoshi
- Journal Title
  
  Stem Cell Reviews and Reports
  
  Volume: 20 Issue: 1 Pages: 347-361
- DOI
  10.1007/s12015-023-10646-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09983, KAKENHI-PROJECT-22K17060
[Journal Article] Extracellular Release of Citrullinated Vimentin Directly Acts on Osteoclasts to Promote Bone Resorption in a Mouse Model of Periodontitis2023
- Author(s)
  Shindo Satoru、Pierrelus Roodelyne、Ikeda Atsushi、Nakamura Shin、Heidari Alireza、Pastore Maria Rita、Leon Elizabeth、Ruiz Sunniva、Chheda Harsh、Khatiwala Rhea、Kumagai Tomoki、Tolson George、Elderbashy Islam、Ouhara Kazuhisa、Han Xiaozhe、Hernandez Maria、Vardar-Sengul Saynur、Shiba Hideki、Kawai Toshihisa
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 8 Pages: 1109-1109
- DOI
  10.3390/cells12081109
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KJ2324, KAKENHI-PROJECT-22K09983
[Journal Article] Relationship Between Periodontitis and Atrial Fibrosis in Atrial Fibrillation2023
- Author(s)
  Miyauchi Shunsuke、Nishi Hiromi、Ouhara Kazuhisa、Tokuyama Takehito、Okubo Yousaku、Okamura Sho、Miyamoto Shogo、Oguri Naoto、Uotani Yukimi、Takasaki Taiichi、Katayama Keijiro、Furusho Hisako、Miyauchi Mutsumi、Takahashi Shinya、Hiyama Toru、Nakano Yukiko
- Journal Title
  
  JACC: Clinical Electrophysiology
  
  Volume: 9 Issue: 1 Pages: 43-53
- DOI
  10.1016/j.jacep.2022.08.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09983, KAKENHI-PROJECT-22K16140, KAKENHI-PROJECT-21K20924
[Journal Article] N-glycan in the variable region of monoclonal ACPA (CCP-Ab1) promotes the exacerbation of experimental arthritis2023
- Author(s)
  Kawataka Masatoshi、Ouhara Kazuhisa、Kobayashi Eiji、Shinoda Koichiro、Tobe Kazuyuki、Fujimori Ryousuke、Mizuno Noriyoshi、Sugiyama Eiji、Ozawa Tatsuhiko、Kishi Hiroyuki
- Journal Title
  
  Rheumatology
  
  Volume: - Issue: 12 Pages: 3968-3977
- DOI
  10.1093/rheumatology/kead130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09983, KAKENHI-PROJECT-21H02782, KAKENHI-PROJECT-21K18261, KAKENHI-PROJECT-21H02962, KAKENHI-PROJECT-23K27423
[Journal Article] Masticatory dysfunction in patients with diabetic neuropathy: A cross-sectional study2022
- Author(s)
  Hamamoto Yuta、Ouhara Kazuhisa、Miyagawa Tsuyoshi、Shintani Tomoaki、Komatsu Nao、Kajiya Mikihito、Matsuda Shinji、Fujita Tsuyoshi、Sasaki Shinya、Iwata Tomoyuki、Ohno Haruya、Yoneda Masayasu、Mizuno Noriyoshi、Kurihara Hidemi
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 6 Pages: e0269594-e0269594
- DOI
  10.1371/journal.pone.0269594
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09983
[Journal Article] Regulation of osteogenesis in bone marrow‐derived mesenchymal stem cells via histone deacetylase 1 and 2 co‐cultured with human gingival fibroblasts and periodontal ligament cells2022
- Author(s)
  Iwata Tomoyuki、Kaneda‐Ikeda Eri、Takahashi Keita、Takeda Katsuhiro、Nagahara Takayoshi、Kajiya Mikihito、Sasaki Shinya、Ishida Shu、Yoshioka Minami、Matsuda Shinji、Ouhara Kazuhisa、Fujita Tsuyoshi、Kurihara Hidemi、Mizuno Noriyoshi
- Journal Title
  
  Journal of Periodontal Research
  
  Volume: 58 Issue: 1 Pages: 83-96
- DOI
  10.1111/jre.13070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09983, KAKENHI-PROJECT-20K09975
[Journal Article] Clumps of mesenchymal stem cells/extracellular matrix complexes directly reconstruct the functional periodontal tissue in a rat periodontal defect model2022
- Author(s)
  Sone Hisakatsu、Kajiya Mikihito、Takeda Katsuhiro、Sasaki Shinya、Horikoshi Susumu、Motoike Souta、Morimoto Shin、Yoshii Hiroki、Yoshino Mai、Iwata Tomoyuki、Ouhara Kazuhisa、Matsuda Shinji、Mizuno Noriyoshi
- Journal Title
  
  Journal of Tissue Engineering and Regenerative Medicine
  
  Volume: 16 Issue: 10 Pages: 945-955
- DOI
  10.1002/term.3343
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09983, KAKENHI-PROJECT-22K17060, KAKENHI-PROJECT-20K09975, KAKENHI-PROJECT-21K21066, KAKENHI-PROJECT-23K24533
[Journal Article] Anti-Inflammatory Effects of Geniposidic Acid on Porphyromonas gingivalis-Induced Periodontitis in Mice2022
- Author(s)
  Tamura Tetsuya、Zhai Ruoqi、Takemura Tasuku、Ouhara Kazuhisa、Taniguchi Yuri、Hamamoto Yuta、Fujimori Ryousuke、Kajiya Mikihito、Matsuda Shinji、Munenaga Syuichi、Fujita Tsuyoshi、Mizuno Noriyoshi
- Journal Title
  
  Biomedicines
  
  Volume: 10 Issue: 12 Pages: 3096-3096
- DOI
  10.3390/biomedicines10123096
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09983, KAKENHI-PROJECT-21K16970, KAKENHI-PROJECT-22K17038
[Journal Article] Xenotransplantation of cryopreserved human clumps of mesenchymal stem cells/extracellular matrix complexes pretreated with IFN-γ induces rat calvarial bone regeneration2022
- Author(s)
  Ogawa Tomoya、Kajiya Mikihito、Horikoshi Susumu、Yoshii Hiroki、Yoshino Mai、Motoike Souta、Morimoto Shin、Sone Hisakatsu、Iwata Tomoyuki、Ouhara Kazuhisa、Matsuda Shinji、Mizuno Noriyoshi
- Journal Title
  
  Regenerative Therapy
  
  Volume: 20 Pages: 117-125
- DOI
  10.1016/j.reth.2022.04.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10129, KAKENHI-PROJECT-22K09983, KAKENHI-PROJECT-22K17060, KAKENHI-PROJECT-20K09975, KAKENHI-PROJECT-21K21066
[Journal Article] Periapical lesion following Cnm-positive Streptococcus mutans pulp infection worsens cerebral hemorrhage onset in an SHRSP rat model2022
- Author(s)
  Taniguchi Yuri、Ouhara Kazuhisa、Kitagawa Masae、Akutagawa Keiichi、Kawada-Matsuo Miki、Tamura Tetsuya、Zhai Ruoqi、Hamamoto Yuta、Kajiya Mikihito、Matsuda Shinji、Maruyama Hirofumi、Komatsuzawa Hitoshi、Shiba Hideki、Mizuno Noriyoshi
- Journal Title
  
  Clinical and Experimental Immunology
  
  Volume: 210 Issue: 3 Pages: 321-330
- DOI
  10.1093/cei/uxac094
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09983, KAKENHI-PROJECT-21H03120, KAKENHI-PROJECT-20K09940, KAKENHI-PROJECT-21K16968
[Journal Article] Functional Regulatory Mechanisms Underlying Bone Marrow Mesenchymal Stem Cell Senescence During Cell Passages2021
- Author(s)
  Iwata T.、Mizuno N.、Ishida S.、Kajiya M.、Nagahara T.、Kaneda-Ikeda E.、Yoshioka M.、Munenaga S.、Ouhara K.、Fujita T.、Kawaguchi H.、Kurihara H.
- Journal Title
  
  Cell Biochemistry and Biophysics
  
  Volume: - Issue: 2 Pages: 321-336
- DOI
  10.1007/s12013-021-00969-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-19K18999
[Journal Article] Selective and easy detection of the Porphyromonas gingivalis fimA type II and IV genes by loop-mediated isothermal amplification2021
- Author(s)
  Kitagawa M, Ouhara K, Oka H, Sakamoto S, Yamane Y, Kashiwagi A, Kanamoto R, Miyauchi M, Nagamine K.
- Journal Title
  
  Journal of Microbiol. Methods
  
  Volume: 185 Pages: 106228-106228
- DOI
  10.1016/j.mimet.2021.106228
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K02352, KAKENHI-PROJECT-20K09940
[Journal Article] The Lipopolysaccharide Mutant Re-LPS Is a Useful Tool for Detecting LPS Contamination in Rheumatoid Synovial Cell Cultures2021
- Author(s)
  Kohno Hiroki、Ouhara Kazuhisa、Mokuda Sho、Tokunaga Tadahiro、Sugimoto Tomohiro、Watanabe Hirofumi、Ishitoku Michinori、Yoshida Yusuke、Mizuno Noriyoshi、Ozawa Tatsuhiko、Kawataka Masatoshi、Hirata Shintaro、Kishi Hiroyuki、Sugiyama Eiji
- Journal Title
  
  Pathobiology
  
  Volume: 89 Issue: 2 Pages: 92-100
- DOI
  10.1159/000520022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07940, KAKENHI-PROJECT-19K08908, KAKENHI-PROJECT-19K18499, KAKENHI-PROJECT-21H02962
[Journal Article] Periodontitis and the outcome of atrial fibrillation ablation: Porphyromonas gingivalis is related to atrial fibrillation recurrence2021
- Author(s)
  Miyauchi Shunsuke、Tokuyama Takehito、Shintani Tomoaki、Nishi Hiromi、Hamamoto Yuta、Ouhara Kazuhisa、Furusho Hisako、Miyauchi Mutsumi、Komatsuzawa Hitoshi、Nakano Yukiko
- Journal Title
  
  Journal of Cardiovascular Electrophysiology
  
  Volume: - Issue: 5 Pages: 1240-1250
- DOI
  10.1111/jce.14952
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-21H03112
[Journal Article] Optineurin regulates osteoblastogenesis through STAT12020
- Author(s)
  Mizuno Noriyoshi、Iwata Tomoyuki、Ohsawa Ryosuke、Ouhara Kazuhisa、Matsuda Shinji、Kajiya Mikihito、Matsuda Yukiko、Kume Kodai、Tada Yui、Morino Hiroyuki、Yoshimoto Tetsuya、Ueki Yasuyoshi、Mihara Keichiro、Sotomaru Yusuke
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 525(4) Issue: 4 Pages: 889-894
- DOI
  10.1016/j.bbrc.2020.03.028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07994, KAKENHI-PROJECT-18H02978, KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-19K18999
[Journal Article] Aggressive periodontitis and NOD2 variants2020
- Author(s)
  Mizuno Noriyoshi, Kume Kodai, Nagatani Yukiko, Matsuda Shinji, Iwata Tomoyuki, Ouhara Kazuhisa, Kajiya Mikihito, Takeda Katsuhiro, Matsuda Yukiko, Tada Yui, Ohsawa Ryosuke, Morino Hiroyuki, Mihara Keichiro, Fujita Tsuyoshi, Kawaguchi Hiroyuki, Shiba Hideki, Kawakami Hideshi, Kurihara Hidemi
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 65(10) Issue: 10 Pages: 841-846
- DOI
  10.1038/s10038-020-0777-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07994, KAKENHI-PROJECT-18H02978, KAKENHI-PROJECT-18K09599
[Journal Article] Regulation of osteogenesis via miR-101-3p in mesenchymal stem cells by human gingival fibroblasts.2020
- Author(s)
  Kaneda-Ikeda E, Iwata T, Mizuno N, Nagahara T, Kajiya M, Ouhara K, Yoshioka M, Ishida S, Kawaguchi H, Kurihara H.
- Journal Title
  
  J Bone Miner Metab.
  
  Volume: Jan 23. Issue: 4 Pages: 442-455
- DOI
  10.1007/s00774-019-01080-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599
[Journal Article] IL-6 Induced by Periodontal Inflammation Causes Neuroinflammation and Disrupts the Blood-Brain Barrier2020
- Author(s)
  Furutama Daisuke、Matsuda Shinji、Yamawaki Yosuke、Hatano Saki、Okanobu Ai、Memida Takumi、Oue Hiroshi、Fujita Tsuyoshi、Ouhara Kazuhisa、Kajiya Mikihito、Mizuno Noriyoshi、Kanematsu Takashi、Tsuga Kazuhiro、Kurihara Hidemi
- Journal Title
  
  Brain Sciences
  
  Volume: 10 Issue: 10 Pages: 679-679
- DOI
  10.3390/brainsci10100679
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599
[Journal Article] Physiologic Target, Molecular Evolution, and Pathogenic Functions of a Monoclonal Anti-Citrullinated Protein Antibody Obtained From a Patient With Rheumatoid Arthritis.2020
- Author(s)
  Ozawa T, Ouhara K, Tsuda R, Munenaga S, Kurihara H, Kohno H, Hamana H, Kobayashi E, Taki H, Tobe K, Sugiyama E, Muraguchi A, Kishi H.
- Journal Title
  
  Arthritis Rheumatol.
  
  Volume: 72 Issue: 12 Pages: 2040-2049
- DOI
  10.1002/art.41426
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08908, KAKENHI-PLANNED-16H06499, KAKENHI-PROJECT-18H02689, KAKENHI-PROJECT-18K09599
[Journal Article] Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model2020
- Author(s)
  Hamamoto Yuta、Ouhara Kazuhisa、Munenaga Syuichi、Shoji Mikio、Ozawa Tatsuhiko、Hisatsune Jyunzo、Kado Isamu、Kajiya Mikihito、Matsuda Shinji、Kawai Toshihisa、Mizuno Noriyoshi、Fujita Tsuyoshi、Hirata Shintaro、Tanimoto Kotaro、Nakayama Koji、Kishi Hiroyuki、Sugiyama Eiji、Kurihara Hidemi
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 22 Issue: 1 Pages: 249-249
- DOI
  10.1186/s13075-020-02348-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07940, KAKENHI-PROJECT-19K08908, KAKENHI-PROJECT-19K10072, KAKENHI-PROJECT-20K09921, KAKENHI-PROJECT-20K18537, KAKENHI-PLANNED-16H06499, KAKENHI-PROJECT-18H02689, KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-19K18999, KAKENHI-PROJECT-19K24073
[Journal Article] Tuning Cytokines Enriches Dendritic Cells and Tregs in the Periodontium2020
- Author(s)
  Sands R. Warren、Verbeke Catia S.、Ouhara Kazuhisa、Silva Eduardo A.、Hsiong Susan、Kawai Toshihisa、Mooney David
- Journal Title
  
  Journal of Periodontology
  
  Volume: in press Issue: 11 Pages: 1475-1485
- DOI
  10.1002/jper.19-0411
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09599
[Journal Article] Rapid detection of the Streptococcus mutans cnm gene by loop-mediated isothermal amplification2020
- Author(s)
  Masae Kitagawa, Kentaro Nagamine, Hiroko Oka, Kazuhisa Ouhara, Ikuko Ogawa, Hitoshi Komatsuzawa, Hidemi Kurihara
- Journal Title
  
  Anal Biochem .
  
  Volume: 605 Pages: 113812-113812
- DOI
  10.1016/j.ab.2020.113812
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K02352, KAKENHI-PROJECT-20K09940, KAKENHI-PROJECT-18K09599
[Journal Article] Cox2-mediated PGE2 production via p38/JNK-c-fos signaling inhibits cell apoptosis in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes2020
- Author(s)
  Komatsu Nao、Kajiya Mikihito、Morimoto Shin、Motoike Souta、Yoshii Hiroki、Iwata Tomoyuki、Ouhara Kazuhisa、Matsuda Shinji、Mizuno Noriyoshi、Kurihara Hidemi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 530 Issue: 2 Pages: 448-454
- DOI
  10.1016/j.bbrc.2020.05.100
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10129, KAKENHI-PROJECT-18H02977, KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-19K19030
[Journal Article] Multiple External Root Resorption of Teeth as a New Manifestation of Systemic Sclerosis-A Cross-Sectional Study in Japan.2019
- Author(s)
  Memida T, Matsuda S, Kajiya M, Mizuno N, Ouhara K, Fujita T, Hirata S, Yoshida Y, Sugimoto T, Nishi H, Kawaguchi H, Sugiyama E, Kurihara H.
- Journal Title
  
  J Clin Med.
  
  Volume: Oct 4;8(10). Issue: 10 Pages: 1628-1628
- DOI
  10.3390/jcm8101628
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599
[Journal Article] Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth?a cross-sectional study in a Japanese population2019
- Author(s)
  Matsuda Shinji、Okanobu Ai、Hatano Saki、Kajiya Mikihito、Sasaki Shinya、Hamamoto Yuta、Iwata Tomoyuki、Ouhara Kazuhisa、Takeda Katsuhiro、Mizuno Noriyoshi、Fujita Tsuyoshi、Kurihara Hidemi
- Journal Title
  
  Clinical Oral Investigations
  
  Volume: - Issue: 11 Pages: 4099-4105
- DOI
  10.1007/s00784-019-02846-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-16K11830
[Journal Article] Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis2019
- Author(s)
  Motoike Souta、Kajiya Mikihito、Komatsu Nao、Horikoshi Susumu、Ogawa Tomoya、Sone Hisakatsu、Matsuda Shinji、Ouhara Kazuhisa、Iwata Tomoyuki、Mizuno Noriyoshi、Fujita Tsuyoshi、Ikeya Makoto、Kurihara Hidemi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 16 Pages: 3970-3970
- DOI
  10.3390/ijms20163970
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-19K10129, KAKENHI-PROJECT-19K19030, KAKENHI-PROJECT-18H02977, KAKENHI-PROJECT-18J13726
[Journal Article] Glycyrrhizic acid suppresses inflammation and reduces the increased glucose levels induced by the combination of Porphyromonas gulae and ligature placement in diabetic model mice2019
- Author(s)
  Akutagawa Keiichi、Fujita Tsuyoshi、Ouhara Kazuhisa、Takemura Tasuku、Tari Misako、Kajiya Mikihito、Matsuda Shinji、Kuramitsu Shohei、Mizuno Noriyoshi、Shiba Hideki、Kurihara Hidemi
- Journal Title
  
  International Immunopharmacology
  
  Volume: 68 Pages: 30-38
- DOI
  10.1016/j.intimp.2018.12.045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-18H02977
[Journal Article] Type I collagen deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes2018
- Author(s)
  Komatsu Nao、Kajiya Mikihito、Motoike Souta、Takewaki Manabu、Horikoshi Susumu、Iwata Tomoyuki、Ouhara Kazuhisa、Takeda Katsuhiro、Matsuda Shinji、Fujita Tsuyoshi、Kurihara Hidemi
- Journal Title
  
  Stem Cell Research & Therapy
  
  Volume: 9 Issue: 1 Pages: 342-342
- DOI
  10.1186/s13287-018-1085-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-17K17351
[Journal Article] The involvement of C5a in the progression of experimental arthritis with Porphyromonas gingivalis infection in SKG mice2018
- Author(s)
  Munenaga Syuichi、Ouhara Kazuhisa、Hamamoto Yuta、Kajiya Mikihito、Takeda Katsuhiro、Yamasaki Satoshi、Kawai Toshihisa、Mizuno Noriyoshi、Fujita Tsuyoshi、Sugiyama Eiji、Kurihara Hidemi
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 20 Issue: 1
- DOI
  10.1186/s13075-018-1744-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09599
[Journal Article] Cryopreserved clumps of mesenchymal stem cell/extracellular matrix complexes retain osteogenic capacity and induce bone regeneration2018
- Author(s)
  Motoike Souta、Kajiya Mikihito、Komatsu Nao、Takewaki Manabu、Horikoshi Susumu、Matsuda Shinji、Ouhara Kazuhisa、Iwata Tomoyuki、Takeda Katsuhiro、Fujita Tsuyoshi、Kurihara Hidemi
- Journal Title
  
  Stem Cell Research & Therapy
  
  Volume: 9 Issue: 1 Pages: 73-73
- DOI
  10.1186/s13287-018-0826-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17351, KAKENHI-PROJECT-15H05053, KAKENHI-PROJECT-15K11390, KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-18J13726
[Journal Article] Regulation of defensive function on gingival epithelial cells can prevent periodontal disease2018
- Author(s)
  Fujita　T., Yoshimoto T., Kajiya M., Ouhara K., Matsuda S., Takemura T., Akutagawa K., Takeda K., Mizuno N., Kurihara H.
- Journal Title
  
  Japanese Dental Science Review
  
  Volume: 印刷中 Issue: 2 Pages: 66-75
- DOI
  10.1016/j.jdsr.2017.11.003
- NAID
  50013109052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11389, KAKENHI-PROJECT-18K09599
[Journal Article] BDNF/HMW-HA complex as an adjunct to nonsurgical periodontal treatment of ligature-induced periodontitis in dogs2018
- Author(s)
  Sasaki Shinya、Takeda Katsuhiro、Takewaki Manabu、Ouhara Kazuhisa、Kajiya Mikihito、Mizuno Noriyoshi、Fujita Tsuyoshi、Kurihara Hidemi
- Journal Title
  
  Journal of Periodontology
  
  Volume: 90 Issue: 1 Pages: 98-109
- DOI
  10.1002/jper.18-0070
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-16K11831
[Journal Article] Reparative bone-like tissue formation in the tooth of a systemic sclerosis patient2018
- Author(s)
  Matsuda S.、Memida T.、Mizuno N.、Ogawa I.、Ouhara K.、Kajiya M.、Fujita T.、Sugiyama E.、Kurihara H.
- Journal Title
  
  International Endodontic Journal
  
  Volume: 26-28 Issue: 9 Pages: 12914-12914
- DOI
  10.1111/iej.12914
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11390, KAKENHI-PROJECT-18K09599
[Journal Article] The induced RNA-binding protein, HuR, targets 3′-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis2018
- Author(s)
  Ouhara K.、Munenaga S.、Kajiya M.、Takeda K.、Matsuda S.、Sato Y.、Hamamoto Y.、Iwata T.、Yamasaki S.、Akutagawa K.、Mizuno N.、Fujita T.、Sugiyama E.、Kurihara H.
- Journal Title
  
  Clinical & Experimental Immunology
  
  Volume: Feb Issue: 3 Pages: 325-336
- DOI
  10.1111/cei.13110
- Data Source
  KAKENHI-PROJECT-15K11390
[Journal Article] Xenotransplantation of interferon-gamma-pretreated clumps of a human mesenchymal stem cell/extracellular matrix complex induces mouse calvarial bone regeneration2017
- Author(s)
  Kei Takeshita, Souta Motoike1, Mikihito Kajiya, Nao Komatsu, Manabu Takewaki, Kazuhisa Ouhara, Tomoyuki Iwata, Katsuhiro Takeda, Noriyoshi Mizuno, Tsuyoshi Fujita, and Hidemi Kurihara
- Journal Title
  
  Stem Cell Research & Therapy
  
  Volume: 8:101 Issue: 1 Pages: 101-101
- DOI
  10.1186/s13287-017-0550-1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H07004, KAKENHI-PROJECT-15K11215, KAKENHI-PROJECT-15K11390
[Journal Article] Retrospective Case Series Analysis to Evaluate Ridge Augmentation Procedure Applied to Immediate Implant Placement in the Esthetic Zone: Five-Year Longitudinal Evaluation Using Cone Beam Computed Tomography2017
- Author(s)
  Takai Yasuhiro、Ouhara Kazuhisa、Movila Alexandru、Kawai Toshihisa
- Journal Title
  
  The International Journal of Periodontics & Restorative Dentistry
  
  Volume: 37 Issue: 4 Pages: 521-530
- DOI
  10.11607/prd.2958
- Data Source
  KAKENHI-PROJECT-15K11390
[Journal Article] MSC/ECM Cellular Complexes Induce Periodontal Tissue Regeneration.2017
- Author(s)
  Takewaki M, Kajiya M, Takeda K, Sasaki S, Motoike S, Komatsu N, Matsuda S, Ouhara K,
- Journal Title
  
  Journal of dental research
  
  Volume: 96(9) Issue: 9 Pages: 984-991
- DOI
  10.1177/0022034517708770
- Open Access
- Data Source
  KAKENHI-PROJECT-15K11215, KAKENHI-PROJECT-15K11390
[Journal Article] Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice.2016
- Author(s)
  Yamakawa M, Ouhara K, Kajiya M, Munenaga S, Kittaka M, Yamasaki S, Takeda K, Takeshita K, Mizuno N, Fujita T, Sugiyama E, Kurihara H.
- Journal Title
  
  Clin Exp Immunol.
  
  Volume: Nov;186(2): Issue: 2 Pages: 177-189
- DOI
  10.1111/cei.12847
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15766, KAKENHI-PROJECT-16K20672, KAKENHI-PROJECT-15K11390
[Journal Article] Mobilization of TLR4 Into Lipid Rafts by Aggregatibacter Actinomycetemcomitans in Gingival Epithelial Cells.2016
- Author(s)
  Imai H, Fujita T, Kajiya M, Ouhara K, Yoshimoto T, Matsuda S, Takeda K, Kurihara H.
- Journal Title
  
  Cell Physiol Biochem.
  
  Volume: 39(5) Pages: 1777-1786
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K11390
[Journal Article] Azithromycin recovers reductions in barrier function in human gingival epithelial cells stimulated with tumor necrosis factor-alfa2016
- Author(s)
  Miyagawa T., Fujita T., Yumoto H., Yoshimoto T., Kajiya M., Ouhara K., Matsuda S., Shiba H., Matsuo T., Kurihara H.
- Journal Title
  
  Arch Oral Biol.
  
  Volume: 62 Pages: 64-69
- DOI
  10.1016/j.archoralbio.2015.11.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11389, KAKENHI-PROJECT-15K11390, KAKENHI-PROJECT-15K15766
[Journal Article] The differential expression of mgl mRNA by Porphyromonas gingivalis affects the production of methyl mercaptan.2015
- Author(s)
  Ouhara Kazuhisa
- Journal Title
  
  Oral Dis.
  
  Volume: Feb 23 Issue: 5 Pages: 626-633
- DOI
  10.1111/odi.12326
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25862051
[Journal Article] Clumps of a mesenchymal stromal cell/extracellular matrix complex can be a novel tissue engineering therapy for bone regeneration.2015
- Author(s)
  Kittaka M, Kajiya M, Shiba H, Takewaki M, Takeshita K, Khung R, Fujita T, Iwata T, Nguyen TQ, Ouhara K, Takeda K, Fujita T, Kurihara H.
- Journal Title
  
  Cytotherapy.
  
  Volume: 2 Issue: 7 Pages: 48-61
- DOI
  10.1016/j.jcyt.2015.01.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390467, KAKENHI-PROJECT-25862051, KAKENHI-PROJECT-26861814, KAKENHI-PROJECT-15H05053, KAKENHI-PROJECT-24593122
[Journal Article] BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade.2014
- Author(s)
  Mikihito Kajiya, Kei Takeshita, Mizuho Kittaka, Shinji Matsuda, Kazuhisa Ouhara, Katsuhiro Takeda, Takashi Takata, Masae Kitagawa, Tsuyoshi Fujita, Hideki Shiba, Hidemi Kurihara
- Journal Title
  
  International Immunopharmacology
  
  Volume: 19(2) Pages: 245-252
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390467
[Journal Article] miR-584 Expressed in Human Gingival Epithelial Cells is Induced by Porphyromonas Gingivalis Stimulation and Regulates Interleukin-8 Production via Lactoferrin Receptor.2013
- Author(s)
  Ouhara K, Savitri IJ, Fujita T, Kittaka M, Kajiya M, Iwata T, Miyagawa T, Yamakawa M, Shiba H, Kurihara H.
- Journal Title
  
  J Periodontol.
  
  Volume: Nov 14.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25862051
[Journal Article] Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans.2013
- Author(s)
  Miyagawa T
- Journal Title
  
  Int Immunopharmacol
  
  Volume: 15 Issue: 2 Pages: 340-347
- DOI
  10.1016/j.intimp.2012.12.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390497, KAKENHI-PROJECT-22792085, KAKENHI-PROJECT-24593123, KAKENHI-PROJECT-24792330
[Journal Article] Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice2013
- Author(s)
  Furusho H, Miyauchi M, Hyogo H, Inubushi T, Ao M, OuharaK, Hisatune J, Kurihara H, Sugai M, Hayes CN, Nakahara T, Aikata H, Takahashi S, Chayama K, Takata T
- Journal Title
  
  J Gastroenterol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22792085
[Journal Article] The antimicrobial peptide LL37 promotes bone regeneration in a rat calvarial bone defect2013
- Author(s)
  Kittaka M., Shiba H., Kajiya M., Fuita T., Iwata T., Rathvisa K., Ouhara K., Takeda K., Fujita T., Komatsuzawa H., Kurihara, H.
- Journal Title
  
  Peptides
  
  Volume: 46 Pages: 136-42
- DOI
  10.1016/j.peptides.2013.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24593122, KAKENHI-PROJECT-25862051
[Journal Article] Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice2013
- Author(s)
  FurushoH,Miyauchi M,Hyogo H,Inubushi T,Ao M,Ouhara K,Hisatune J,Kurihara H,Sugai M,Hayes CN,Nakahara T,Akikata H,Takahashi S,Chayama K,Takata T
- Journal Title
  
  J Gastroenterol
  
  Volume: 48(11) Issue: 11 Pages: 1259-70
- DOI
  10.1007/s00535-012-0738-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890138, KAKENHI-PROJECT-25462855, KAKENHI-PROJECT-25862051
[Journal Article] Expression levels of novel cytokine IL-32 in periodontitis and its role in the suppression of IL-8 production by human gingival fibroblasts stimulated with Porphyromonas gingivalis2012
- Author(s)
  Ouhara K, Kawai T, Silva MJ, Fujita T, Hayashida K, Karimbux NY, Kajiya M, Shiba H, Kawaguchi H, Kurihara H
- Journal Title
  
  J Oral Microbiol
  
  Volume: 4 Issue: 1 Pages: 14832-14832
- DOI
  10.3402/jom.v4i0.14832
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] LAMP法による唾液中 Aggregatibacter actinomycetemcomitans簡易検出法の確立2023
- Author(s)
  平井公人,北川雅恵,長嶺憲太郎,應原一久,宮内俊介,宮内睦美,高柴正悟
- Organizer
  第16回日本口腔検査学会学術大会
- Data Source
  KAKENHI-PROJECT-23K09201
[Presentation] Periodontal infection in diet-induced obesity causes cognitive impairment associated with microglial activation.2023
- Author(s)
  Kana Oue, Yusuke Morioka, Eiji Imado, Testuya Tamura, Yosuke Yamawaki, Kazuhisa Ouhara, Mitsuhiro Yoshida, Takashi Kanematsu, Yukio Ago
- Organizer
  IAGG Asia/Oceania Regional Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K09183
[Presentation] Oral infection (periodontal disease, peri-implantitis) and Systemic Disease2023
- Author(s)
  Kazuhisa Ouhara
- Organizer
  7th JSMID and 1st COMID
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09983
[Presentation] 歯周病原細菌Porphyromonas gingivalis感染が影響する関節リウマチとSDGs2022
- Author(s)
  應原　一久
- Organizer
  第７６回　NPO法人　日本口腔科学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K09983
[Presentation] Cnm陽性Streptococcus mutans 歯髄感染が脳出血を誘導するメカニズムの解明2022
- Author(s)
  谷口友梨、應原一久、北川雅恵、松尾美樹、濱本結太、加治屋幹人、松田真司、丸山博文、小松澤　均、柴　秀樹、水野智仁
- Organizer
  日本歯科保存学会2022年度秋季学術大会（第157回）
- Data Source
  KAKENHI-PROJECT-21H03120
[Presentation] Cnm陽性Streptococcus mutans歯髄感染が脳出血を誘導するメカニズムの解明2022
- Author(s)
  谷口友梨、應原一久、北川雅恵、松尾美樹、濱本結太、加治屋幹人、松田真司、丸山博文、小松澤均、柴秀樹、水野智仁
- Organizer
  日本歯科保存学会2022年度（秋季）学術大会（第157回）
- Data Source
  KAKENHI-PROJECT-22K09983
[Presentation] porphyromonas gingivalis由来ジンジパイン抗体の歯周組織破壊への影響についての検討2022
- Author(s)
  田村哲也、應原一久, Ruoqi Zhai, 竹村翼, 谷口友梨, 濱本結太, 藤森良介, 加治屋幹人, 松田真司, 宗永修一, 藤田剛, 水野智仁
- Organizer
  第65回　秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-22K09983
[Presentation] リウマチ滑膜細胞のTLR4活性化研究におけるLPSのコンタミネーションの検出に、変異型LPS・Re-LPSは有用である2021
- Author(s)
  河野紘輝、應原一久、徳永忠浩、茂久田翔、水野智仁、小澤龍彦、川高正聖、平田信太郎、岸裕幸、杉山英二
- Organizer
  第３６回日本臨床リウマチ学会
- Data Source
  KAKENHI-PROJECT-19K08908
[Presentation] 歯周病原細菌に対する歯周組織局所の免疫応答が及ぼす全身疾患への影響2020
- Author(s)
  應原　一久
- Organizer
  日本歯周病学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K09599
[Presentation] 関節リウマチ患者由来抗シトルリン化ペプチド抗体を用いた破骨細胞分化抑制作用について2019
- Author(s)
  應原　一久、宗永　修一、平田　信太郎、杉山　英二、栗原　英見
- Organizer
  第63回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K09599
[Presentation] A human ACPA monoclonal antibody is preferably localized at inflammatory gingival tissue and activates osteoclastogenensis in Porphyromonas gingivalis infected SKG mouse2018
- Author(s)
  Kazuhisa Ouhara
- Organizer
  2018 american collage of rheumatology annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09599
[Presentation] The localization of ACPA derived from RA patient in periodontal tissue of mouse periodontitis model2018
- Author(s)
  應原　一久
- Organizer
  第６２回　日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K09599
[Presentation] Porphyromonas gingivalis infection exacerbates rheumatoid arthritis in mice model.2016
- Author(s)
  山川真宏、應原一久　高田隆、　栗原英見
- Organizer
  国際歯科学会（韓国　ソウル）
- Place of Presentation
  ソウル、大韓民国
- Year and Date
  2016-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11390
[Presentation] 歯周病原細菌Porphyromonas gingivalis感染の関節リウマチへの影響についての検討2016
- Author(s)
  宗永修一、應原一久　山川真宏　山崎聡士　杉山英二　栗原英見
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  横浜市
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15K11390
[Presentation] 歯周病原細菌Porphyromonas gingivalis感染の関節リウマチへの影響についての検討2016
- Author(s)
  宗永修一、應原一久　山川真宏　山崎聡士　杉山英二　栗原英見
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  横浜市
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15K15766
[Presentation] コウボクはPorphyromonas gingivalisのmglを介したメチルメルカプタン産生を抑制する2016
- Author(s)
  佐藤陽子、應原一久　宗永修一　加冶屋幹人　水野智仁　藤田剛　栗原英見
- Organizer
  日本歯科保存学会２０１６年度秋季学術大会（第１４５回）
- Place of Presentation
  長野県松本市
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-15K15766
[Presentation] Porphyromonas gingivalis infection exacerbates rheumatoid arthritis in mice model.2016
- Author(s)
  山川真宏、應原一久　高田隆、　栗原英見
- Organizer
  国際歯科学会（韓国　ソウル）
- Place of Presentation
  ソウル、大韓民国
- Year and Date
  2016-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15766
[Presentation] 歯周組織における neonatal Fc receptor を介した歯周病原細菌由来免疫複合体の能動輸送2014
- Author(s)
  應原一久
- Organizer
  第８７回日本細菌学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25862051
[Presentation] 骨髄間葉系幹細胞集塊Clumps of mesenchymal stem cells/extracellular matrix complexを利用した新規組織再生療法開発2014
- Author(s)
  加治屋幹人、橘高瑞穂、柴　秀樹、竹脇　学、竹下　慶、岩田倫幸、應原一久、武田克浩、
- Organizer
  第57回秋季日本歯周病学会学術大会
- Place of Presentation
  神戸市
- Year and Date
  2014-10-19
- Data Source
  KAKENHI-PROJECT-24390467
[Presentation] 嚢胞様根尖病巣由来滲出液中のサイトカイン産生量プロファイリング2012
- Author(s)
  應原一久
- Organizer
  第5回日本口腔検査学会総会・学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] 根尖病変を「宿主－寄生体相互作用」の概念から捉えた新しい検査・治療法の確立2012
- Author(s)
  應原　一久
- Organizer
  日本歯科保存学会　2012秋季学術大会（第137回）
- Place of Presentation
  広島市
- Invited
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] 広島大学病院歯周診療科・口臭外来における口臭検査　－平成22－23年度受診患者の傾向－2012
- Author(s)
  應原　一久
- Organizer
  日本歯周病学会　第7回　中国地区臨床研修会
- Place of Presentation
  松江市
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] 嚢胞様根尖病巣由来滲出液中のサイトカイン産生量プロファイリング2012
- Author(s)
  應原　一久
- Organizer
  第５回日本口腔検査学会総会・学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] 嚢胞様根尖病巣に対する選択的抗菌薬療法2012
- Author(s)
  應原　一久
- Organizer
  第22回日本歯科医学会総会
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] ヒト歯肉上皮細胞におけるPorphyromonas gingivalis刺激時のmicroRNA発現の網羅的解析2012
- Author(s)
  應原　一久
- Organizer
  日本歯周病学会　2012秋季学術大会
- Place of Presentation
  つくば市
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] 嚢胞様根尖病巣由来滲出液中のサイトカイン産生量プロファイリング2012
- Author(s)
  應原　一久
- Organizer
  第51回広島県歯科医学会・第96回広島大学歯学会
- Place of Presentation
  広島市
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] ヒト末梢血単核球におけるIL-32の破骨細胞への影響2011
- Author(s)
  應原一久
- Organizer
  第134回日本歯科保存学会学術大会
- Place of Presentation
  浦安市
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] 炎症性サイトカインIL-32の歯周組織における発現およびPBMCに対する作用2010
- Author(s)
  應原一久
- Organizer
  第53回日本歯周病学会学術大会
- Place of Presentation
  盛岡市
- Year and Date
  2010-05-15
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] The-break-of-immunetolerance to oral-commensal-bacteria leads to periodontal bone loss in mouse2010
- Author(s)
  應原一久
- Organizer
  International Assiciation of Dental Research
- Place of Presentation
  Balcerona, Spain
- Year and Date
  2010-07-17
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] Molecular analysis of Omp29-like pathogenic antigen from P.pneumotropica in mouse periodontitis2010
- Author(s)
  應原一久
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  横浜市
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-21890165
[Presentation] 広島大学病院口腔検査センターにおけるPorphyromonas gingivalisに対する血清抗体価検査
- Author(s)
  應原一久
- Organizer
  第７回日本口腔検査学会総会・学術大会
- Place of Presentation
  岡山市
- Year and Date
  2014-09-06 – 2014-09-07
- Data Source
  KAKENHI-PROJECT-25862051
[Presentation] 歯周病原細菌Porphyromonas gingivalis 感染の全身疾患への影響
- Author(s)
  應原一久
- Organizer
  無菌生物ノートバイオロジー学会総会
- Place of Presentation
  広島市
- Year and Date
  2015-01-30 – 2015-01-31
- Invited
- Data Source
  KAKENHI-PROJECT-25862051
[Presentation] The molecular analysis of Rheumatoid Arthritis-related gene LRG1 in periodontitis
- Author(s)
  應原一久
- Organizer
  International association of dental research
- Place of Presentation
  アメリカ合衆国　ボストン
- Year and Date
  2015-03-11 – 2015-03-14
- Data Source
  KAKENHI-PROJECT-25862051

1. Ozawa Tatsuhiko (10432105)

# of Collaborated Projects: 6 results

# of Collaborated Products: 3 results
2. MIZUNO Noriyoshi (60325181)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. KURIHARA HIDEMI (40161765)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
4. SUGIYAMA EIJI (70179167)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
5. Miyauchi Mutsumi (50169265)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
6. 藤田剛 (80379883)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
7. 松田真司 (30611321)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
8. UCHIDA Yuushi (40363080)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. Kitagawa Masae (10403627)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
10. 長嶺憲太郎 (80412352)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
11. 松尾美樹 (20527048)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
12. KATO Kouichi (50283875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. IWATA Tomoyuki (30418793)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. Shiba Hideki (60260668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 二川浩樹 (10228140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 中野由紀子 (10397911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 小松澤均 (90253088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 作村諭一 (50324968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 向下寿子 (00634461)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 新谷智章 (90403518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 武田克浩 (10452591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 丸山博文 (90304443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. 庄子幹郎 (10336175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 平田信太郎 (90525461)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
25. 大植香菜 (60760329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
26. 森岡徳光 (20346505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
27. 吾郷由希夫 (50403027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
28. 宮内俊介 (30910799)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
29. 川高正聖 (90990028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 吉本哲也 (60758209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
31. MORINO Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
32. MIKIHITO Kajiya

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
33. Komatsu Nao

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. AKUTAGAWA KEIICHI

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. TAKEMURA TASUKU

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. MIYAGAWA TSUYOSHI

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. TAKEDA Katsuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. FURUSHO Hisako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 松田由喜子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Ouhara Kazuhisa 應原 一久

OUHARA Kazuhisa 應原 一久

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Elucidation of the Inhibitory Mechanism of Periodontal Tissue Destruction against Antigens from Periodontopathogenic Bacteria Using Antibody Modification TechnologyPrincipal Investigator

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Elucidation of the mechanism of periodontal tissue destruction by ACPA derived from patients with rheumatoid arthritis and periodontopathogenic bacteria-related proteinsPrincipal Investigator

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The induced RNA-binding protein, HuR targets of IL-6 mRNA and enhances its stabilization in periodontitisPrincipal Investigator

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The bidirectional effect of Leucine-rich alpha-2-glycoprotein 1 (LRG1) in rheumatoid arthritis and periodontitisPrincipal Investigator

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Ouhara Kazuhisa 應原一久

OUHARA Kazuhisa 應原一久