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Ouhara Kazuhisa  應原 一久

… Alternative Names

OUHARA Kazuhisa  應原 一久

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Researcher Number 80550425
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-6796-884X
Affiliation (Current) 2022: 広島大学, 医系科学研究科(歯), 助教
Affiliation (based on the past Project Information) *help 2022: 広島大学, その他の研究科, 助教
2019 – 2021: 広島大学, 医系科学研究科(歯), 助教
2017 – 2018: 広島大学, 医歯薬保健学研究科(歯), 助教
2013 – 2016: 広島大学, 医歯薬保健学研究院(歯), 助教
2015: 広島大学, 大学院医歯薬保健学研究院, 助教 … More
2014 – 2015: 広島大学, 医歯薬保健学研究院, 助教
2014: 広島大学, 大学院医歯薬保健学研究院(歯), 助教
2012: 広島大学, 医歯薬保健学研究院, 助教
2012: 広島大学, 大学院・医歯薬保健学研究院, 助教
2009 – 2011: Hiroshima University, 大学院・医歯薬学総合研究科, 助教
2010: Hiroshima University, 医歯(薬)学総合研究科, 助教 Less
Review Section/Research Field
Principal Investigator
Periodontal dentistry / Periodontology / Basic Section 57030:Conservative dentistry-related
Except Principal Investigator
Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 57030:Conservative dentistry-related / Periodontal dentistry / Conservative dentistry / Periodontology / Basic Section 57020:Oral pathobiological science-related
Keywords
Principal Investigator
歯周炎 / 歯肉上皮細胞 / 抗体 / 能動輸送 / 歯周病原細菌 / 関節リウマチ / FcRn / Ig / IgG / リウマチ … More / サイトカイン / LRG1 / RNA結合タンパク質 / 歯周病源細菌 / ケルセチン / シトルリン化タンパク質 / RNA安定化タンパク質 / RNA binding protein / マウス / IL-6 … More
Except Principal Investigator
関節リウマチ / 間葉系幹細胞 / セメント芽細胞 / 歯周靭帯細胞 / 歯周組織再生 / マイクロRNA / マイクロRNA / セメント質形成 / 糖尿病 / 歯内疾患 / 好中球 / RAGE / 歯髄由来繊維芽細胞 / 歯内病変 / 歯髄炎 / 根尖性歯周炎 / 糖最終産物の受容体 / 歯周炎 / バクテリミア / 腸内細菌叢 / バクテレミア / 抗シトルリン化ペプチド抗体 / SKGマウス / 破骨細胞 / 滑膜細胞 / モノクローナルACPA / N-結合型糖鎖 / 歯周病原細菌 / 心房細動 / 歯周病 / ビッグデータ解析 / Cnm陽性う蝕原因細菌 / 脳出血 / PRIP / 健康寿命の延伸 / 口腔内細菌 / 口腔検査 / cnm / LAMP法 / 口腔細菌遺伝子 / 迅速検出法 / 全身疾患 Less
  • Research Projects

    (14 results)
  • Research Products

    (62 results)
  • Co-Researchers

    (43 People)
  •  関節リウマチ患者由来ACPAと歯周病原菌関連タンパクによる歯周組織破壊機序の解明Principal Investigator

    • Principal Investigator
      應原 一久
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      Hiroshima University
  •  Elucidation of the pathological mechanism of rheumatoid arthritis induced by N-linked glycans in the ACPA variable region

    • Principal Investigator
      小澤 龍彦
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      University of Toyama
  •  Comprehensive study on the effects of periodontal pathogen on the pathophysiology of atrial fibrillation

    • Principal Investigator
      宮内 睦美
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57020:Oral pathobiological science-related
    • Research Institution
      Hiroshima University
  •  Cnm陽性う蝕原因細菌のPRIPを介した脳出血増悪機序解明による健康寿命の延伸

    • Principal Investigator
      柴 秀樹
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      Hiroshima University
  •  Establishment of rapid detection method for oral bacterial genes associated with systemic diseases

    • Principal Investigator
      北川 雅恵
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      Hiroshima University
  •  関節リウマチ患者由来抗シトルリン化ペプチド抗体を用いた破骨細胞分化抑制剤の開発

    • Principal Investigator
      杉山 英二
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      Hiroshima University
  •  The induced RNA-binding protein, HuR targets of IL-6 mRNA and enhances its stabilization in periodontitisPrincipal Investigator

    • Principal Investigator
      Ouhara Kazuhisa
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      Hiroshima University
  •  The bidirectional effect of Leucine-rich alpha-2-glycoprotein 1 (LRG1) in rheumatoid arthritis and periodontitisPrincipal Investigator

    • Principal Investigator
      Ouhara Kazuhisa
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontology
    • Research Institution
      Hiroshima University
  •  The basic research for the prevention of periodontitis induced bacterimia by using probiotics

    • Principal Investigator
      Kurihara Hidemi
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Periodontology
    • Research Institution
      Hiroshima University
  •  Elucidate the mechanism of aggravation of endodontic disease on diabetic patients

    • Principal Investigator
      Uchida Yushi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Conservative dentistry
    • Research Institution
      Hiroshima University
  •  The effect of PAD derived from periodontopathogenic bacteria in rheumatoid arthritisPrincipal Investigator

    • Principal Investigator
      OUHARA Kazuhisa
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Periodontology
    • Research Institution
      Hiroshima University
  •  Induction of cementoblastic differentiation from mesenchymal stem cells and cementogenesis on dentin surface

    • Principal Investigator
      KURIHARA HIDEMI
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Hiroshima University
  •  The analysis and application for periodontal treatment of FcRn which is tha passive IgG transporter in epithelial cellsPrincipal Investigator

    • Principal Investigator
      OUHARA Kazuhisa
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Hiroshima University
  •  上皮細胞が産生するIgG能動輸送タンパク質FcRnによる歯周炎治療法の開発Principal Investigator

    • Principal Investigator
      應原 一久
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Periodontal dentistry
    • Research Institution
      Hiroshima University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

  • [Journal Article] Functional Regulatory Mechanisms Underlying Bone Marrow Mesenchymal Stem Cell Senescence During Cell Passages2021

    • Author(s)
      Iwata T.、Mizuno N.、Ishida S.、Kajiya M.、Nagahara T.、Kaneda-Ikeda E.、Yoshioka M.、Munenaga S.、Ouhara K.、Fujita T.、Kawaguchi H.、Kurihara H.
    • Journal Title

      Cell Biochemistry and Biophysics

      Volume: - Pages: 321-336

    • DOI

      10.1007/s12013-021-00969-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-19K18999
  • [Journal Article] Periodontitis and the outcome of atrial fibrillation ablation: Porphyromonas gingivalis is related to atrial fibrillation recurrence2021

    • Author(s)
      Miyauchi Shunsuke、Tokuyama Takehito、Shintani Tomoaki、Nishi Hiromi、Hamamoto Yuta、Ouhara Kazuhisa、Furusho Hisako、Miyauchi Mutsumi、Komatsuzawa Hitoshi、Nakano Yukiko
    • Journal Title

      Journal of Cardiovascular Electrophysiology

      Volume: -

    • DOI

      10.1111/jce.14952

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09599
  • [Journal Article] Regulation of osteogenesis via miR-101-3p in mesenchymal stem cells by human gingival fibroblasts.2020

    • Author(s)
      Kaneda-Ikeda E, Iwata T, Mizuno N, Nagahara T, Kajiya M, Ouhara K, Yoshioka M, Ishida S, Kawaguchi H, Kurihara H.
    • Journal Title

      J Bone Miner Metab.

      Volume: Jan 23.

    • DOI

      10.1007/s00774-019-01080-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09599
  • [Journal Article] Rapid detection of the Streptococcus mutans cnm gene by loop-mediated isothermal amplification.2020

    • Author(s)
      Masae Kitagawa, Kentaro Nagamine, Hiroko Oka, Kazuhisa Ouhara, Ikuko Ogawa, Hitoshi Komatsuzawa, Hidemi Kurihara
    • Journal Title

      Analytical Biochemistry

      Volume: 605 Pages: 113812-113812

    • DOI

      10.1016/j.ab.2020.113812

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K02352, KAKENHI-PROJECT-20K09940, KAKENHI-PROJECT-18K09599
  • [Journal Article] Optineurin regulates osteoblastogenesis through STAT12020

    • Author(s)
      Mizuno Noriyoshi、Iwata Tomoyuki、Ohsawa Ryosuke、Ouhara Kazuhisa、Matsuda Shinji、Kajiya Mikihito、Matsuda Yukiko、Kume Kodai、Tada Yui、Morino Hiroyuki、Yoshimoto Tetsuya、Ueki Yasuyoshi、Mihara Keichiro、Sotomaru Yusuke
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 525(4) Pages: 889-894

    • DOI

      10.1016/j.bbrc.2020.03.028

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07994, KAKENHI-PROJECT-18H02978, KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-19K18999
  • [Journal Article] Tuning cytokines enriches dendritic cells and regulatory T cells in the periodontium2020

    • Author(s)
      Sands R. Warren、Verbeke Catia S.、Ouhara Kazuhisa、Silva Eduardo A.、Hsiong Susan、Kawai Toshihisa、Mooney David
    • Journal Title

      Journal of Periodontology

      Volume: 91 Pages: 1475-1485

    • DOI

      10.1002/jper.19-0411

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09599
  • [Journal Article] Cox2-mediated PGE2 production via p38/JNK-c-fos signaling inhibits cell apoptosis in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes2020

    • Author(s)
      Komatsu Nao、Kajiya Mikihito、Morimoto Shin、Motoike Souta、Yoshii Hiroki、Iwata Tomoyuki、Ouhara Kazuhisa、Matsuda Shinji、Mizuno Noriyoshi、Kurihara Hidemi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 530 Pages: 448-454

    • DOI

      10.1016/j.bbrc.2020.05.100

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10129, KAKENHI-PROJECT-18H02977, KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-19K19030
  • [Journal Article] Aggressive periodontitis and NOD2 variants2020

    • Author(s)
      Mizuno Noriyoshi, Kume Kodai, Nagatani Yukiko, Matsuda Shinji, Iwata Tomoyuki, Ouhara Kazuhisa, Kajiya Mikihito, Takeda Katsuhiro, Matsuda Yukiko, Tada Yui, Ohsawa Ryosuke, Morino Hiroyuki, Mihara Keichiro, Fujita Tsuyoshi, Kawaguchi Hiroyuki, Shiba Hideki, Kawakami Hideshi, Kurihara Hidemi
    • Journal Title

      Journal of Human Genetics

      Volume: 65(10) Pages: 841-846

    • DOI

      10.1038/s10038-020-0777-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07994, KAKENHI-PROJECT-18H02978, KAKENHI-PROJECT-18K09599
  • [Journal Article] IL-6 Induced by Periodontal Inflammation Causes Neuroinflammation and Disrupts the Blood-Brain Barrier2020

    • Author(s)
      Furutama Daisuke、Matsuda Shinji、Yamawaki Yosuke、Hatano Saki、Okanobu Ai、Memida Takumi、Oue Hiroshi、Fujita Tsuyoshi、Ouhara Kazuhisa、Kajiya Mikihito、Mizuno Noriyoshi、Kanematsu Takashi、Tsuga Kazuhiro、Kurihara Hidemi
    • Journal Title

      Brain Sciences

      Volume: 10 Pages: 679-679

    • DOI

      10.3390/brainsci10100679

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09599
  • [Journal Article] Physiologic target, molecular evolution, and pathogenic functions of a monoclonal anti-citrullinated protein antibody obtained from a patient with rheumatoid arthritis.2020

    • Author(s)
      Ozawa T, Ouhara K, Tsuda R, Munenaga S, Kurihara H, Kohno H, Hamana H, Kobayashi E, Taki H, Tobe K, Sugiyama E, Muraguchi A, Kishi H.
    • Journal Title

      Arthritis & Rheumatology

      Volume: 72 Pages: 2040-2049

    • DOI

      10.1002/art.41426

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08908, KAKENHI-PLANNED-16H06499, KAKENHI-PROJECT-18H02689, KAKENHI-PROJECT-18K09599
  • [Journal Article] Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model.2020

    • Author(s)
      Hamamoto Yuta、Ouhara Kazuhisa、Munenaga Syuichi、Shoji Mikio、Ozawa Tatsuhiko、Hisatsune Jyunzo、Kado Isamu、Kajiya Mikihito、Matsuda Shinji、Kawai Toshihisa、Mizuno Noriyoshi、Fujita Tsuyoshi、Hirata Shintaro、Tanimoto Kotaro、Nakayama Koji、Kishi Hiroyuki、Sugiyama Eiji、Kurihara Hidemi
    • Journal Title

      Arthritis Res. Ther.

      Volume: 22 Pages: 249-249

    • DOI

      10.1186/s13075-020-02348-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07940, KAKENHI-PROJECT-19K08908, KAKENHI-PROJECT-19K10072, KAKENHI-PROJECT-20K09921, KAKENHI-PROJECT-20K18537, KAKENHI-PLANNED-16H06499, KAKENHI-PROJECT-18H02689, KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-19K18999, KAKENHI-PROJECT-19K24073
  • [Journal Article] Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth-a cross-sectional study in a Japanese population2019

    • Author(s)
      Matsuda Shinji、Okanobu Ai、Hatano Saki、Kajiya Mikihito、Sasaki Shinya、Hamamoto Yuta、Iwata Tomoyuki、Ouhara Kazuhisa、Takeda Katsuhiro、Mizuno Noriyoshi、Fujita Tsuyoshi、Kurihara Hidemi
    • Journal Title

      Clin Oral Investig.

      Volume: - Pages: 4099-4105

    • DOI

      10.1007/s00784-019-02846-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-16K11830
  • [Journal Article] Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis2019

    • Author(s)
      Motoike Souta、Kajiya Mikihito、Komatsu Nao、Horikoshi Susumu、Ogawa Tomoya、Sone Hisakatsu、Matsuda Shinji、Ouhara Kazuhisa、Iwata Tomoyuki、Mizuno Noriyoshi、Fujita Tsuyoshi、Ikeya Makoto、Kurihara Hidemi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Pages: 3970-3970

    • DOI

      10.3390/ijms20163970

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-19K10129, KAKENHI-PROJECT-19K19030, KAKENHI-PROJECT-18H02977, KAKENHI-PROJECT-18J13726
  • [Journal Article] Type I collagen deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes.2019

    • Author(s)
      Akutagawa Keiichi、Fujita Tsuyoshi、Ouhara Kazuhisa、Takemura Tasuku、Tari Misako、Kajiya Mikihito、Matsuda Shinji、Kuramitsu Shohei、Mizuno Noriyoshi、Shiba Hideki、Kurihara Hidemi
    • Journal Title

      Stem Cell Res Ther

      Volume: 68 Pages: 342-342

    • DOI

      10.1016/j.intimp.2018.12.045

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-18H02977
  • [Journal Article] Multiple External Root Resorption of Teeth as a New Manifestation of Systemic Sclerosis-A Cross-Sectional Study in Japan.2019

    • Author(s)
      Memida T, Matsuda S, Kajiya M, Mizuno N, Ouhara K, Fujita T, Hirata S, Yoshida Y, Sugimoto T, Nishi H, Kawaguchi H, Sugiyama E, Kurihara H.
    • Journal Title

      J Clin Med.

      Volume: Oct 4;8(10).

    • DOI

      10.3390/jcm8101628

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09599
  • [Journal Article] BDNF/HMW-HA complex as an adjunct to nonsurgical periodontal treatment of ligature-induced periodontitis in dogs2019

    • Author(s)
      Sasaki Shinya、Takeda Katsuhiro、Takewaki Manabu、Ouhara Kazuhisa、Kajiya Mikihito、Mizuno Noriyoshi、Fujita Tsuyoshi、Kurihara Hidemi
    • Journal Title

      Journal of Periodontology

      Volume: 90 Pages: 98-109

    • DOI

      10.1002/jper.18-0070

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-16K11831
  • [Journal Article] Type I collagen deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes.2018

    • Author(s)
      Komatsu Nao、Kajiya Mikihito、Motoike Souta、Takewaki Manabu、Horikoshi Susumu、Iwata Tomoyuki、Ouhara Kazuhisa、Takeda Katsuhiro、Matsuda Shinji、Fujita Tsuyoshi、Kurihara Hidemi
    • Journal Title

      Stem Cell Res Ther

      Volume: 9 Pages: 342-342

    • DOI

      10.1186/s13287-018-1085-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-17K17351
  • [Journal Article] The involvement of C5a in the progression of experimental arthritis with Porphyromonas gingivalis infection in SKG mice2018

    • Author(s)
      Munenaga Syuichi、Ouhara Kazuhisa、Hamamoto Yuta、Kajiya Mikihito、Takeda Katsuhiro、Yamasaki Satoshi、Kawai Toshihisa、Mizuno Noriyoshi、Fujita Tsuyoshi、Sugiyama Eiji、Kurihara Hidemi
    • Journal Title

      Arthritis Research & Therapy

      Volume: 20

    • DOI

      10.1186/s13075-018-1744-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09599
  • [Journal Article] Cryopreserved clumps of mesenchymal stem cell/extracellular matrix complexes retain osteogenic capacity and induce bone regeneration2018

    • Author(s)
      Motoike Souta、Kajiya Mikihito、Komatsu Nao、Takewaki Manabu、Horikoshi Susumu、Matsuda Shinji、Ouhara Kazuhisa、Iwata Tomoyuki、Takeda Katsuhiro、Fujita Tsuyoshi、Kurihara Hidemi
    • Journal Title

      Stem Cell Research & Therapy

      Volume: 9 Pages: 73-73

    • DOI

      10.1186/s13287-018-0826-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K17351, KAKENHI-PROJECT-15H05053, KAKENHI-PROJECT-15K11390, KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-18J13726
  • [Journal Article] Reparative bone-like tissue formation in the tooth of a systemic sclerosis patient2018

    • Author(s)
      Matsuda S.、Memida T.、Mizuno N.、Ogawa I.、Ouhara K.、Kajiya M.、Fujita T.、Sugiyama E.、Kurihara H.
    • Journal Title

      International Endodontic Journal

      Volume: 26-28 Pages: 1059-1066

    • DOI

      10.1111/iej.12914

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K11390, KAKENHI-PROJECT-18K09599
  • [Journal Article] Regulation of defensive function on gingival epithelial cells can prevent periodontal disease2018

    • Author(s)
      Fujita T., Yoshimoto T., Kajiya M., Ouhara K., Matsuda S., Takemura T., Akutagawa K., Takeda K., Mizuno N., Kurihara H.
    • Journal Title

      Japanese Dental Science Review

      Volume: 印刷中 Issue: 2 Pages: 66-75

    • DOI

      10.1016/j.jdsr.2017.11.003

    • NAID

      50013109052

    • ISSN
      1882-7616
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K11389, KAKENHI-PROJECT-18K09599
  • [Journal Article] The induced RNA-binding protein, HuR, targets 3′-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis2018

    • Author(s)
      Ouhara K.、Munenaga S.、Kajiya M.、Takeda K.、Matsuda S.、Sato Y.、Hamamoto Y.、Iwata T.、Yamasaki S.、Akutagawa K.、Mizuno N.、Fujita T.、Sugiyama E.、Kurihara H.
    • Journal Title

      Clinical & Experimental Immunology

      Volume: Feb

    • DOI

      10.1111/cei.13110

    • Data Source
      KAKENHI-PROJECT-15K11390
  • [Journal Article] Xenotransplantation of interferon-gammapretreated clumps of a human mesenchymal stem cell/extracellular matrix complex induces mouse calvarial bone regeneration2017

    • Author(s)
      Kei Takeshita, Souta Motoike1, Mikihito Kajiya, Nao Komatsu, Manabu Takewaki, Kazuhisa Ouhara, Tomoyuki Iwata, Katsuhiro Takeda, Noriyoshi Mizuno, Tsuyoshi Fujita, and Hidemi Kurihara
    • Journal Title

      Stem Cell Research & Therary

      Volume: 8:101 Pages: 101-101

    • DOI

      10.1186/s13287-017-0550-1

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H07004, KAKENHI-PROJECT-15K11215, KAKENHI-PROJECT-15K11390
  • [Journal Article] MSC/ECM Cellular Complexes Induce Periodontal Tissue Regeneration2017

    • Author(s)
      Takewaki M, Kajiya M, Takeda K, Sasaki S, Motoike S, Komatsu N, Matsuda S, Ouhara K,
    • Journal Title

      Journal of Dental Research

      Volume: 96(9) Pages: 984-991

    • DOI

      10.1177/0022034517708770

    • Open Access
    • Data Source
      KAKENHI-PROJECT-15K11215, KAKENHI-PROJECT-15K11390
  • [Journal Article] Retrospective Case Series Analysis to Evaluate Ridge Augmentation Procedure Applied to Immediate Implant Placement in the Esthetic Zone: Five-Year Longitudinal Evaluation Using Cone Beam Computed Tomography2017

    • Author(s)
      Takai Yasuhiro、Ouhara Kazuhisa、Movila Alexandru、Kawai Toshihisa
    • Journal Title

      The International Journal of Periodontics & Restorative Dentistry

      Volume: 37 Pages: 521-530

    • DOI

      10.11607/prd.2958

    • Data Source
      KAKENHI-PROJECT-15K11390
  • [Journal Article] Mobilization of TLR4 Into Lipid Rafts by Aggregatibacter Actinomycetemcomitans in Gingival Epithelial Cells.2016

    • Author(s)
      Imai H, Fujita T, Kajiya M, Ouhara K, Yoshimoto T, Matsuda S, Takeda K, Kurihara H.
    • Journal Title

      Cell Physiol Biochem.

      Volume: 39(5) Pages: 1777-1786

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K11390
  • [Journal Article] Azithromycin recovers reductions in barrier function in human gingival epithelial cells stimulated with tumor necrosis factor-α.2016

    • Author(s)
      Miyagawa T., Fujita T., Yumoto H., Yoshimoto T., Kajiya M., Ouhara K., Matsuda S., Shiba H., Matsuo T., Kurihara H.
    • Journal Title

      Arch Oral Biol.

      Volume: 62 Pages: 64-69

    • DOI

      10.1016/j.archoralbio.2015.11.015

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K11389, KAKENHI-PROJECT-15K11390, KAKENHI-PROJECT-15K15766
  • [Journal Article] Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice.2016

    • Author(s)
      Yamakawa M, Ouhara K, Kajiya M, Munenaga S, Kittaka M, Yamasaki S, Takeda K, Takeshita K, Mizuno N, Fujita T, Sugiyama E, Kurihara H.
    • Journal Title

      Clin Exp Immunol

      Volume: Nov;186(2): Pages: 177-189

    • DOI

      10.1111/cei.12847

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15766, KAKENHI-PROJECT-16K20672, KAKENHI-PROJECT-15K11390
  • [Journal Article] The differential expression of mgl mRNA by Porphyromonas gingivalis affects the production of methyl mercaptan.2015

    • Author(s)
      Ouhara Kazuhisa
    • Journal Title

      Oral Dis.

      Volume: Feb 23

    • DOI

      10.1111/odi.12326

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25862051
  • [Journal Article] Clumps of a mesenchymal stromal cell/extracellular matrix complex can be a novel tissue engineering therapy for bone regeneration2015

    • Author(s)
      Kittaka M, Kajiya M, Shiba H, Takewaki M, Takeshita K, Khung R, Fujita T, Iwata T, Nguyen TQ, Ouhara K, Takeda K, Fujita T, Kurihara H.
    • Journal Title

      Cytotherapy

      Volume: 2 Pages: 00048-1

    • DOI

      10.1016/j.jcyt.2015.01.007

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390467, KAKENHI-PROJECT-25862051, KAKENHI-PROJECT-26861814, KAKENHI-PROJECT-15H05053, KAKENHI-PROJECT-24593122
  • [Journal Article] BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade.2014

    • Author(s)
      Mikihito Kajiya, Kei Takeshita, Mizuho Kittaka, Shinji Matsuda, Kazuhisa Ouhara, Katsuhiro Takeda, Takashi Takata, Masae Kitagawa, Tsuyoshi Fujita, Hideki Shiba, Hidemi Kurihara
    • Journal Title

      International Immunopharmacology

      Volume: 19(2) Pages: 245-252

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390467
  • [Journal Article] 9. Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice.2013

    • Author(s)
      FurushoH,Miyauchi M,Hyogo H,Inubushi T,Ao M,Ouhara K,Hisatune J,Kurihara H,Sugai M,Hayes CN,Nakahara T,Akikata H,Takahashi S,Chayama K,Takata T
    • Journal Title

      J Gastroenterol.

      Volume: 48(11) Pages: 1259-70

    • DOI

      10.1007/s00535-012-0738-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24890138, KAKENHI-PROJECT-25462855, KAKENHI-PROJECT-25862051
  • [Journal Article] miR-584 Expressed in Human Gingival Epithelial Cells is Induced by Porphyromonas Gingivalis Stimulation and Regulates Interleukin-8 Production via Lactoferrin Receptor.2013

    • Author(s)
      Ouhara K, Savitri IJ, Fujita T, Kittaka M, Kajiya M, Iwata T, Miyagawa T, Yamakawa M, Shiba H, Kurihara H.
    • Journal Title

      J Periodontol.

      Volume: Nov 14.

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25862051
  • [Journal Article] Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans2013

    • Author(s)
      Miyagawa T
    • Journal Title

      International Immunopharmacology

      Volume: 15 Pages: 340-347

    • DOI

      10.1016/j.intimp.2012.12.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390497, KAKENHI-PROJECT-22792085, KAKENHI-PROJECT-24593123, KAKENHI-PROJECT-24792330
  • [Journal Article] Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice2013

    • Author(s)
      Furusho H, Miyauchi M, Hyogo H, Inubushi T, Ao M, OuharaK, Hisatune J, Kurihara H, Sugai M, Hayes CN, Nakahara T, Aikata H, Takahashi S, Chayama K, Takata T
    • Journal Title

      J Gastroenterol

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22792085
  • [Journal Article] The antimicrobial peptide LL37 promotes bone regeneration in a rat calvarial bone defect.2013

    • Author(s)
      Kittaka M., Shiba H., Kajiya M., Fuita T., Iwata T., Rathvisa K., Ouhara K., Takeda K., Fujita T., Komatsuzawa H., Kurihara, H.
    • Journal Title

      Peptides.

      Volume: 46 Pages: 136-42

    • DOI

      10.1016/j.peptides.2013.06.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24593122, KAKENHI-PROJECT-25862051
  • [Journal Article] Expression levels of novel cytokine IL-32 in periodontitis and its role in the suppression of IL-8 production by human gingival fibroblasts stimulated with Porphyromonas gingivalis.2012

    • Author(s)
      Ouhara K, Kawai T, Silva MJ, Fujita T, Hayashida K, Karimbux NY, Kajiya M, Shiba H, Kawaguchi H, Kurihara H
    • Journal Title

      J Oral Microbiol.

      Volume: 4

    • DOI

      10.3402/jom.v4i0.14832

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22792085
  • [Presentation] 歯周病原細菌に対する歯周組織局所の免疫応答が及ぼす全身疾患への影響2020

    • Author(s)
      應原 一久
    • Organizer
      日本歯周病学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K09599
  • [Presentation] 関節リウマチ患者由来抗シトルリン化ペプチド抗体を用いた破骨細胞分化抑制作用について2019

    • Author(s)
      應原 一久、宗永 修一、平田 信太郎、杉山 英二、栗原 英見
    • Organizer
      第63回日本リウマチ学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-18K09599
  • [Presentation] The localization of ACPA derived from RA patient in periodontal tissue of mouse periodontitis model2018

    • Author(s)
      應原 一久
    • Organizer
      第62回 日本リウマチ学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-18K09599
  • [Presentation] A human ACPA monoclonal antibody is preferably localized at inflammatory gingival tissue and activates osteoclastogenensis in Porphyromonas gingivalis infected SKG mouse2018

    • Author(s)
      Kazuhisa Ouhara
    • Organizer
      2018 american collage of rheumatology annual meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09599
  • [Presentation] コウボクはPorphyromonas gingivalisのmglを介したメチルメルカプタン産生を抑制する2016

    • Author(s)
      佐藤陽子、應原一久 宗永修一 加冶屋幹人 水野智仁 藤田剛 栗原英見
    • Organizer
      日本歯科保存学会2016年度秋季学術大会(第145回)
    • Place of Presentation
      長野県松本市
    • Year and Date
      2016-10-27
    • Data Source
      KAKENHI-PROJECT-15K15766
  • [Presentation] Porphyromonas gingivalis infection exacerbates rheumatoid arthritis in mice model.2016

    • Author(s)
      山川真宏、應原一久 高田隆、 栗原英見
    • Organizer
      国際歯科学会(韓国 ソウル)
    • Place of Presentation
      ソウル、大韓民国
    • Year and Date
      2016-06-20
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K11390
  • [Presentation] 歯周病原細菌Porphyromonas gingivalis感染の関節リウマチへの影響についての検討2016

    • Author(s)
      宗永修一、應原一久 山川真宏 山崎聡士 杉山英二 栗原英見
    • Organizer
      第60回日本リウマチ学会総会・学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-04-21
    • Data Source
      KAKENHI-PROJECT-15K11390
  • [Presentation] 歯周病原細菌Porphyromonas gingivalis感染の関節リウマチへの影響についての検討2016

    • Author(s)
      宗永修一、應原一久 山川真宏 山崎聡士 杉山英二 栗原英見
    • Organizer
      第60回日本リウマチ学会総会・学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-04-21
    • Data Source
      KAKENHI-PROJECT-15K15766
  • [Presentation] Porphyromonas gingivalis infection exacerbates rheumatoid arthritis in mice model.2016

    • Author(s)
      山川真宏、應原一久 高田隆、 栗原英見
    • Organizer
      国際歯科学会(韓国 ソウル)
    • Place of Presentation
      ソウル、大韓民国
    • Year and Date
      2016-06-20
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15766
  • [Presentation] 骨髄間葉系幹細胞集塊Clumps of mesenchymal stem cells/extracellular matrix complexを利用した新規組織再生療法開発2014

    • Author(s)
      加治屋幹人、橘高瑞穂、柴 秀樹、竹脇 学、竹下 慶、岩田倫幸、應原一久、武田克浩、
    • Organizer
      第57回秋季日本歯周病学会学術大会
    • Place of Presentation
      神戸市
    • Year and Date
      2014-10-19
    • Data Source
      KAKENHI-PROJECT-24390467
  • [Presentation] 歯周組織における neonatal Fc receptor を介した歯周病原細菌由来免疫複合体の能動輸送2014

    • Author(s)
      應原一久
    • Organizer
      第87回日本細菌学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-25862051
  • [Presentation] 嚢胞様根尖病巣由来滲出液中のサイトカイン産生量プロファイリング2012

    • Author(s)
      應原 一久
    • Organizer
      第5回日本口腔検査学会総会・学術大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22792085
  • [Presentation] 嚢胞様根尖病巣由来滲出液中のサイトカイン産生量プロファイリング2012

    • Author(s)
      應原 一久
    • Organizer
      第5回日本口腔検査学会総会・学術大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22792085
  • [Presentation] 嚢胞様根尖病巣由来滲出液中のサイトカイン産生量プロファイリング2012

    • Author(s)
      應原 一久
    • Organizer
      第51回広島県歯科医学会・第96回広島大学歯学会
    • Place of Presentation
      広島市
    • Data Source
      KAKENHI-PROJECT-22792085
  • [Presentation] 嚢胞様根尖病巣に対する選択的抗菌薬療法2012

    • Author(s)
      應原 一久
    • Organizer
      第22回日本歯科医学会総会
    • Place of Presentation
      大阪市
    • Data Source
      KAKENHI-PROJECT-22792085
  • [Presentation] 根尖病変を「宿主-寄生体相互作用」の概念から捉えた新しい検査・治療法の確立2012

    • Author(s)
      應原 一久
    • Organizer
      日本歯科保存学会 2012秋季学術大会(第137回)
    • Place of Presentation
      広島市
    • Invited
    • Data Source
      KAKENHI-PROJECT-22792085
  • [Presentation] 広島大学病院歯周診療科・口臭外来における口臭検査 -平成22-23年度受診患者の傾向-2012

    • Author(s)
      應原 一久
    • Organizer
      日本歯周病学会 第7回 中国地区臨床研修会
    • Place of Presentation
      松江市
    • Data Source
      KAKENHI-PROJECT-22792085
  • [Presentation] ヒト歯肉上皮細胞におけるPorphyromonas gingivalis刺激時のmicroRNA発現の網羅的解析2012

    • Author(s)
      應原 一久
    • Organizer
      日本歯周病学会 2012秋季学術大会
    • Place of Presentation
      つくば市
    • Data Source
      KAKENHI-PROJECT-22792085
  • [Presentation] ヒト末梢血単核球におけるIL-32の破骨細胞への影響2011

    • Author(s)
      應原一久
    • Organizer
      第134回日本歯科保存学会学術大会
    • Place of Presentation
      浦安市
    • Year and Date
      2011-06-09
    • Data Source
      KAKENHI-PROJECT-22792085
  • [Presentation] 炎症性サイトカインIL-32の歯周組織における発現およびPBMCに対する作用2010

    • Author(s)
      應原一久
    • Organizer
      第53回日本歯周病学会学術大会
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-05-15
    • Data Source
      KAKENHI-PROJECT-22792085
  • [Presentation] Molecular analysis of Omp29-like pathogenic antigen from P.pneumotropica in mouse periodontitis2010

    • Author(s)
      應原一久
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-03-27
    • Data Source
      KAKENHI-PROJECT-21890165
  • [Presentation] The-break-of-immunetolerance to oral-commensal-bacteria leads to periodontal bone loss in mouse2010

    • Author(s)
      應原一久
    • Organizer
      International Assiciation of Dental Research
    • Place of Presentation
      Balcerona, Spain
    • Year and Date
      2010-07-17
    • Data Source
      KAKENHI-PROJECT-22792085
  • [Presentation] 広島大学病院口腔検査センターにおけるPorphyromonas gingivalisに対する血清抗体価検査

    • Author(s)
      應原一久
    • Organizer
      第7回日本口腔検査学会総会・学術大会
    • Place of Presentation
      岡山市
    • Year and Date
      2014-09-06 – 2014-09-07
    • Data Source
      KAKENHI-PROJECT-25862051
  • [Presentation] The molecular analysis of Rheumatoid Arthritis-related gene LRG1 in periodontitis

    • Author(s)
      應原一久
    • Organizer
      International association of dental research
    • Place of Presentation
      アメリカ合衆国 ボストン
    • Year and Date
      2015-03-11 – 2015-03-14
    • Data Source
      KAKENHI-PROJECT-25862051
  • [Presentation] 歯周病原細菌Porphyromonas gingivalis 感染の全身疾患への影響

    • Author(s)
      應原一久
    • Organizer
      無菌生物ノートバイオロジー学会総会
    • Place of Presentation
      広島市
    • Year and Date
      2015-01-30 – 2015-01-31
    • Invited
    • Data Source
      KAKENHI-PROJECT-25862051
  • 1.  KURIHARA HIDEMI (40161765)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 13 results
  • 2.  藤田 剛 (80379883)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 26 results
  • 3.  小澤 龍彦 (10432105)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
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    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 7.  KATO Kouichi (50283875)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MIZUNO Noriyoshi (60325181)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
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    # of Collaborated Products: 0 results
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    # of Collaborated Products: 0 results
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    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Products: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
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    # of Collaborated Products: 1 results
  • 23.  INUBUSHI Toshihiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  MIKIHITO Kajiya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 11 results
  • 25.  Komatsu Nao
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 26.  MIYAGAWA TSUYOSHI
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    # of Collaborated Products: 1 results
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    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
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    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
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    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
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    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
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    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
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    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
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    # of Collaborated Products: 1 results
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    # of Collaborated Products: 1 results
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    # of Collaborated Products: 1 results
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    # of Collaborated Products: 3 results
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    # of Collaborated Products: 4 results
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    # of Collaborated Products: 2 results
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  • 40.  岸 裕幸
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  • 41.  庄子 幹郎
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  • 42.  中山 浩次
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  • 43.  濱本 結太
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