Ouhara Kazuhisa 應原一久

… Alternative Names

Researcher Number	80550425
Other IDs	https://orcid.org/0000-0001-6796-884X
Affiliation (Current)	2022: 広島大学, 医系科学研究科(歯), 助教
Affiliation (based on the past Project Information) *help	2022: 広島大学, その他の研究科, 助教 2019 – 2021: 広島大学, 医系科学研究科(歯), 助教 2017 – 2018: 広島大学, 医歯薬保健学研究科(歯), 助教 2013 – 2016: 広島大学, 医歯薬保健学研究院(歯), 助教 2015: 広島大学, 大学院医歯薬保健学研究院, 助教 … More
Review Section/Research Field	Principal Investigator Periodontal dentistry / Periodontology / Basic Section 57030:Conservative dentistry-related Except Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 57030:Conservative dentistry-related / Periodontal dentistry / Conservative dentistry / Periodontology / Basic Section 57020:Oral pathobiological science-related
Keywords	Principal Investigator 歯周炎 / 歯肉上皮細胞 / 抗体 / 能動輸送 / 歯周病原細菌 / 関節リウマチ / FcRn / Ig / IgG / リウマチ … More Except Principal Investigator 関節リウマチ / 間葉系幹細胞 / セメント芽細胞 / 歯周靭帯細胞 / 歯周組織再生 / マイクロＲＮＡ / マイクロRNA / セメント質形成 / 糖尿病 / 歯内疾患 / 好中球 / RAGE / 歯髄由来繊維芽細胞 / 歯内病変 / 歯髄炎 / 根尖性歯周炎 / 糖最終産物の受容体 / 歯周炎 / バクテリミア / 腸内細菌叢 / バクテレミア / 抗シトルリン化ペプチド抗体 / ＳＫＧマウス / 破骨細胞 / 滑膜細胞 / モノクローナルACPA / N-結合型糖鎖 / 歯周病原細菌 / 心房細動 / 歯周病 / ビッグデータ解析 / Cnm陽性う蝕原因細菌 / 脳出血 / PRIP / 健康寿命の延伸 / 口腔内細菌 / 口腔検査 / cnm / LAMP法 / 口腔細菌遺伝子 / 迅速検出法 / 全身疾患 Less

関節リウマチ患者由来ACPAと歯周病原菌関連タンパクによる歯周組織破壊機序の解明Principal Investigator
- Principal Investigator
  
  應原一久
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
Elucidation of the pathological mechanism of rheumatoid arthritis induced by N-linked glycans in the ACPA variable region
- Principal Investigator
  
  小澤龍彦
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  University of Toyama
Comprehensive study on the effects of periodontal pathogen on the pathophysiology of atrial fibrillation
- Principal Investigator
  
  宮内睦美
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Hiroshima University
Cnm陽性う蝕原因細菌のPRIPを介した脳出血増悪機序解明による健康寿命の延伸
- Principal Investigator
  
  柴秀樹
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
Establishment of rapid detection method for oral bacterial genes associated with systemic diseases
- Principal Investigator
  
  北川雅恵
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
関節リウマチ患者由来抗シトルリン化ペプチド抗体を用いた破骨細胞分化抑制剤の開発
- Principal Investigator
  
  杉山英二
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Hiroshima University
The induced RNA-binding protein, HuR targets of IL-6 mRNA and enhances its stabilization in periodontitisPrincipal Investigator
- Principal Investigator
  
  Ouhara Kazuhisa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hiroshima University
The bidirectional effect of Leucine-rich alpha-2-glycoprotein 1 (LRG1) in rheumatoid arthritis and periodontitisPrincipal Investigator
- Principal Investigator
  
  Ouhara Kazuhisa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Hiroshima University
The basic research for the prevention of periodontitis induced bacterimia by using probiotics
- Principal Investigator
  
  Kurihara Hidemi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Periodontology
- Research Institution
  Hiroshima University
Elucidate the mechanism of aggravation of endodontic disease on diabetic patients
- Principal Investigator
  
  Uchida Yushi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Hiroshima University
The effect of PAD derived from periodontopathogenic bacteria in rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  OUHARA Kazuhisa
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontology
- Research Institution
  Hiroshima University
Induction of cementoblastic differentiation from mesenchymal stem cells and cementogenesis on dentin surface
- Principal Investigator
  
  KURIHARA HIDEMI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Hiroshima University
The analysis and application for periodontal treatment of FcRn which is tha passive IgG transporter in epithelial cellsPrincipal Investigator
- Principal Investigator
  
  OUHARA Kazuhisa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Hiroshima University
上皮細胞が産生するIgG能動輸送タンパク質FcRnによる歯周炎治療法の開発Principal Investigator
- Principal Investigator
  
  應原一久
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Periodontal dentistry
- Research Institution
  Hiroshima University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Functional Regulatory Mechanisms Underlying Bone Marrow Mesenchymal Stem Cell Senescence During Cell Passages2021
- Author(s)
  Iwata T.、Mizuno N.、Ishida S.、Kajiya M.、Nagahara T.、Kaneda-Ikeda E.、Yoshioka M.、Munenaga S.、Ouhara K.、Fujita T.、Kawaguchi H.、Kurihara H.
- Journal Title
  
  Cell Biochemistry and Biophysics
  
  Volume: - Pages: 321-336
- DOI
  10.1007/s12013-021-00969-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-19K18999
[Journal Article] Periodontitis and the outcome of atrial fibrillation ablation: Porphyromonas gingivalis is related to atrial fibrillation recurrence2021
- Author(s)
  Miyauchi Shunsuke、Tokuyama Takehito、Shintani Tomoaki、Nishi Hiromi、Hamamoto Yuta、Ouhara Kazuhisa、Furusho Hisako、Miyauchi Mutsumi、Komatsuzawa Hitoshi、Nakano Yukiko
- Journal Title
  
  Journal of Cardiovascular Electrophysiology
  
  Volume: -
- DOI
  10.1111/jce.14952
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599
[Journal Article] Regulation of osteogenesis via miR-101-3p in mesenchymal stem cells by human gingival fibroblasts.2020
- Author(s)
  Kaneda-Ikeda E, Iwata T, Mizuno N, Nagahara T, Kajiya M, Ouhara K, Yoshioka M, Ishida S, Kawaguchi H, Kurihara H.
- Journal Title
  
  J Bone Miner Metab.
  
  Volume: Jan 23.
- DOI
  10.1007/s00774-019-01080-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599
[Journal Article] Rapid detection of the Streptococcus mutans cnm gene by loop-mediated isothermal amplification.2020
- Author(s)
  Masae Kitagawa, Kentaro Nagamine, Hiroko Oka, Kazuhisa Ouhara, Ikuko Ogawa, Hitoshi Komatsuzawa, Hidemi Kurihara
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 605 Pages: 113812-113812
- DOI
  10.1016/j.ab.2020.113812
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K02352, KAKENHI-PROJECT-20K09940, KAKENHI-PROJECT-18K09599
[Journal Article] Optineurin regulates osteoblastogenesis through STAT12020
- Author(s)
  Mizuno Noriyoshi、Iwata Tomoyuki、Ohsawa Ryosuke、Ouhara Kazuhisa、Matsuda Shinji、Kajiya Mikihito、Matsuda Yukiko、Kume Kodai、Tada Yui、Morino Hiroyuki、Yoshimoto Tetsuya、Ueki Yasuyoshi、Mihara Keichiro、Sotomaru Yusuke
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 525(4) Pages: 889-894
- DOI
  10.1016/j.bbrc.2020.03.028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07994, KAKENHI-PROJECT-18H02978, KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-19K18999
[Journal Article] Tuning cytokines enriches dendritic cells and regulatory T cells in the periodontium2020
- Author(s)
  Sands R. Warren、Verbeke Catia S.、Ouhara Kazuhisa、Silva Eduardo A.、Hsiong Susan、Kawai Toshihisa、Mooney David
- Journal Title
  
  Journal of Periodontology
  
  Volume: 91 Pages: 1475-1485
- DOI
  10.1002/jper.19-0411
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09599
[Journal Article] Cox2-mediated PGE2 production via p38/JNK-c-fos signaling inhibits cell apoptosis in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes2020
- Author(s)
  Komatsu Nao、Kajiya Mikihito、Morimoto Shin、Motoike Souta、Yoshii Hiroki、Iwata Tomoyuki、Ouhara Kazuhisa、Matsuda Shinji、Mizuno Noriyoshi、Kurihara Hidemi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 530 Pages: 448-454
- DOI
  10.1016/j.bbrc.2020.05.100
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10129, KAKENHI-PROJECT-18H02977, KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-19K19030
[Journal Article] Aggressive periodontitis and NOD2 variants2020
- Author(s)
  Mizuno Noriyoshi, Kume Kodai, Nagatani Yukiko, Matsuda Shinji, Iwata Tomoyuki, Ouhara Kazuhisa, Kajiya Mikihito, Takeda Katsuhiro, Matsuda Yukiko, Tada Yui, Ohsawa Ryosuke, Morino Hiroyuki, Mihara Keichiro, Fujita Tsuyoshi, Kawaguchi Hiroyuki, Shiba Hideki, Kawakami Hideshi, Kurihara Hidemi
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 65(10) Pages: 841-846
- DOI
  10.1038/s10038-020-0777-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07994, KAKENHI-PROJECT-18H02978, KAKENHI-PROJECT-18K09599
[Journal Article] IL-6 Induced by Periodontal Inflammation Causes Neuroinflammation and Disrupts the Blood-Brain Barrier2020
- Author(s)
  Furutama Daisuke、Matsuda Shinji、Yamawaki Yosuke、Hatano Saki、Okanobu Ai、Memida Takumi、Oue Hiroshi、Fujita Tsuyoshi、Ouhara Kazuhisa、Kajiya Mikihito、Mizuno Noriyoshi、Kanematsu Takashi、Tsuga Kazuhiro、Kurihara Hidemi
- Journal Title
  
  Brain Sciences
  
  Volume: 10 Pages: 679-679
- DOI
  10.3390/brainsci10100679
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599
[Journal Article] Physiologic target, molecular evolution, and pathogenic functions of a monoclonal anti-citrullinated protein antibody obtained from a patient with rheumatoid arthritis.2020
- Author(s)
  Ozawa T, Ouhara K, Tsuda R, Munenaga S, Kurihara H, Kohno H, Hamana H, Kobayashi E, Taki H, Tobe K, Sugiyama E, Muraguchi A, Kishi H.
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: 72 Pages: 2040-2049
- DOI
  10.1002/art.41426
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08908, KAKENHI-PLANNED-16H06499, KAKENHI-PROJECT-18H02689, KAKENHI-PROJECT-18K09599
[Journal Article] Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model.2020
- Author(s)
  Hamamoto Yuta、Ouhara Kazuhisa、Munenaga Syuichi、Shoji Mikio、Ozawa Tatsuhiko、Hisatsune Jyunzo、Kado Isamu、Kajiya Mikihito、Matsuda Shinji、Kawai Toshihisa、Mizuno Noriyoshi、Fujita Tsuyoshi、Hirata Shintaro、Tanimoto Kotaro、Nakayama Koji、Kishi Hiroyuki、Sugiyama Eiji、Kurihara Hidemi
- Journal Title
  
  Arthritis Res. Ther.
  
  Volume: 22 Pages: 249-249
- DOI
  10.1186/s13075-020-02348-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07940, KAKENHI-PROJECT-19K08908, KAKENHI-PROJECT-19K10072, KAKENHI-PROJECT-20K09921, KAKENHI-PROJECT-20K18537, KAKENHI-PLANNED-16H06499, KAKENHI-PROJECT-18H02689, KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-19K18999, KAKENHI-PROJECT-19K24073
[Journal Article] Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth-a cross-sectional study in a Japanese population2019
- Author(s)
  Matsuda Shinji、Okanobu Ai、Hatano Saki、Kajiya Mikihito、Sasaki Shinya、Hamamoto Yuta、Iwata Tomoyuki、Ouhara Kazuhisa、Takeda Katsuhiro、Mizuno Noriyoshi、Fujita Tsuyoshi、Kurihara Hidemi
- Journal Title
  
  Clin Oral Investig.
  
  Volume: - Pages: 4099-4105
- DOI
  10.1007/s00784-019-02846-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-16K11830
[Journal Article] Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis2019
- Author(s)
  Motoike Souta、Kajiya Mikihito、Komatsu Nao、Horikoshi Susumu、Ogawa Tomoya、Sone Hisakatsu、Matsuda Shinji、Ouhara Kazuhisa、Iwata Tomoyuki、Mizuno Noriyoshi、Fujita Tsuyoshi、Ikeya Makoto、Kurihara Hidemi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Pages: 3970-3970
- DOI
  10.3390/ijms20163970
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-19K10129, KAKENHI-PROJECT-19K19030, KAKENHI-PROJECT-18H02977, KAKENHI-PROJECT-18J13726
[Journal Article] Type I collagen deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes.2019
- Author(s)
  Akutagawa Keiichi、Fujita Tsuyoshi、Ouhara Kazuhisa、Takemura Tasuku、Tari Misako、Kajiya Mikihito、Matsuda Shinji、Kuramitsu Shohei、Mizuno Noriyoshi、Shiba Hideki、Kurihara Hidemi
- Journal Title
  
  Stem Cell Res Ther
  
  Volume: 68 Pages: 342-342
- DOI
  10.1016/j.intimp.2018.12.045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-18H02977
[Journal Article] Multiple External Root Resorption of Teeth as a New Manifestation of Systemic Sclerosis-A Cross-Sectional Study in Japan.2019
- Author(s)
  Memida T, Matsuda S, Kajiya M, Mizuno N, Ouhara K, Fujita T, Hirata S, Yoshida Y, Sugimoto T, Nishi H, Kawaguchi H, Sugiyama E, Kurihara H.
- Journal Title
  
  J Clin Med.
  
  Volume: Oct 4;8(10).
- DOI
  10.3390/jcm8101628
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599
[Journal Article] BDNF/HMW-HA complex as an adjunct to nonsurgical periodontal treatment of ligature-induced periodontitis in dogs2019
- Author(s)
  Sasaki Shinya、Takeda Katsuhiro、Takewaki Manabu、Ouhara Kazuhisa、Kajiya Mikihito、Mizuno Noriyoshi、Fujita Tsuyoshi、Kurihara Hidemi
- Journal Title
  
  Journal of Periodontology
  
  Volume: 90 Pages: 98-109
- DOI
  10.1002/jper.18-0070
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-16K11831
[Journal Article] Type I collagen deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes.2018
- Author(s)
  Komatsu Nao、Kajiya Mikihito、Motoike Souta、Takewaki Manabu、Horikoshi Susumu、Iwata Tomoyuki、Ouhara Kazuhisa、Takeda Katsuhiro、Matsuda Shinji、Fujita Tsuyoshi、Kurihara Hidemi
- Journal Title
  
  Stem Cell Res Ther
  
  Volume: 9 Pages: 342-342
- DOI
  10.1186/s13287-018-1085-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-17K17351
[Journal Article] The involvement of C5a in the progression of experimental arthritis with Porphyromonas gingivalis infection in SKG mice2018
- Author(s)
  Munenaga Syuichi、Ouhara Kazuhisa、Hamamoto Yuta、Kajiya Mikihito、Takeda Katsuhiro、Yamasaki Satoshi、Kawai Toshihisa、Mizuno Noriyoshi、Fujita Tsuyoshi、Sugiyama Eiji、Kurihara Hidemi
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 20
- DOI
  10.1186/s13075-018-1744-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09599
[Journal Article] Cryopreserved clumps of mesenchymal stem cell/extracellular matrix complexes retain osteogenic capacity and induce bone regeneration2018
- Author(s)
  Motoike Souta、Kajiya Mikihito、Komatsu Nao、Takewaki Manabu、Horikoshi Susumu、Matsuda Shinji、Ouhara Kazuhisa、Iwata Tomoyuki、Takeda Katsuhiro、Fujita Tsuyoshi、Kurihara Hidemi
- Journal Title
  
  Stem Cell Research & Therapy
  
  Volume: 9 Pages: 73-73
- DOI
  10.1186/s13287-018-0826-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17351, KAKENHI-PROJECT-15H05053, KAKENHI-PROJECT-15K11390, KAKENHI-PROJECT-18K09599, KAKENHI-PROJECT-18J13726
[Journal Article] Reparative bone-like tissue formation in the tooth of a systemic sclerosis patient2018
- Author(s)
  Matsuda S.、Memida T.、Mizuno N.、Ogawa I.、Ouhara K.、Kajiya M.、Fujita T.、Sugiyama E.、Kurihara H.
- Journal Title
  
  International Endodontic Journal
  
  Volume: 26-28 Pages: 1059-1066
- DOI
  10.1111/iej.12914
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11390, KAKENHI-PROJECT-18K09599
[Journal Article] Regulation of defensive function on gingival epithelial cells can prevent periodontal disease2018
- Author(s)
  Fujita　T., Yoshimoto T., Kajiya M., Ouhara K., Matsuda S., Takemura T., Akutagawa K., Takeda K., Mizuno N., Kurihara H.
- Journal Title
  
  Japanese Dental Science Review
  
  Volume: 印刷中 Issue: 2 Pages: 66-75
- DOI
  10.1016/j.jdsr.2017.11.003
- NAID
  50013109052
- ISSN
  1882-7616
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11389, KAKENHI-PROJECT-18K09599
[Journal Article] The induced RNA-binding protein, HuR, targets 3′-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis2018
- Author(s)
  Ouhara K.、Munenaga S.、Kajiya M.、Takeda K.、Matsuda S.、Sato Y.、Hamamoto Y.、Iwata T.、Yamasaki S.、Akutagawa K.、Mizuno N.、Fujita T.、Sugiyama E.、Kurihara H.
- Journal Title
  
  Clinical & Experimental Immunology
  
  Volume: Feb
- DOI
  10.1111/cei.13110
- Data Source
  KAKENHI-PROJECT-15K11390
[Journal Article] Xenotransplantation of interferon-gammapretreated clumps of a human mesenchymal stem cell/extracellular matrix complex induces mouse calvarial bone regeneration2017
- Author(s)
  Kei Takeshita, Souta Motoike1, Mikihito Kajiya, Nao Komatsu, Manabu Takewaki, Kazuhisa Ouhara, Tomoyuki Iwata, Katsuhiro Takeda, Noriyoshi Mizuno, Tsuyoshi Fujita, and Hidemi Kurihara
- Journal Title
  
  Stem Cell Research & Therary
  
  Volume: 8:101 Pages: 101-101
- DOI
  10.1186/s13287-017-0550-1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H07004, KAKENHI-PROJECT-15K11215, KAKENHI-PROJECT-15K11390
[Journal Article] MSC/ECM Cellular Complexes Induce Periodontal Tissue Regeneration2017
- Author(s)
  Takewaki M, Kajiya M, Takeda K, Sasaki S, Motoike S, Komatsu N, Matsuda S, Ouhara K,
- Journal Title
  
  Journal of Dental Research
  
  Volume: 96(9) Pages: 984-991
- DOI
  10.1177/0022034517708770
- Open Access
- Data Source
  KAKENHI-PROJECT-15K11215, KAKENHI-PROJECT-15K11390
[Journal Article] Retrospective Case Series Analysis to Evaluate Ridge Augmentation Procedure Applied to Immediate Implant Placement in the Esthetic Zone: Five-Year Longitudinal Evaluation Using Cone Beam Computed Tomography2017
- Author(s)
  Takai Yasuhiro、Ouhara Kazuhisa、Movila Alexandru、Kawai Toshihisa
- Journal Title
  
  The International Journal of Periodontics & Restorative Dentistry
  
  Volume: 37 Pages: 521-530
- DOI
  10.11607/prd.2958
- Data Source
  KAKENHI-PROJECT-15K11390
[Journal Article] Mobilization of TLR4 Into Lipid Rafts by Aggregatibacter Actinomycetemcomitans in Gingival Epithelial Cells.2016
- Author(s)
  Imai H, Fujita T, Kajiya M, Ouhara K, Yoshimoto T, Matsuda S, Takeda K, Kurihara H.
- Journal Title
  
  Cell Physiol Biochem.
  
  Volume: 39(5) Pages: 1777-1786
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K11390
[Journal Article] Azithromycin recovers reductions in barrier function in human gingival epithelial cells stimulated with tumor necrosis factor-α.2016
- Author(s)
  Miyagawa T., Fujita T., Yumoto H., Yoshimoto T., Kajiya M., Ouhara K., Matsuda S., Shiba H., Matsuo T., Kurihara H.
- Journal Title
  
  Arch Oral Biol.
  
  Volume: 62 Pages: 64-69
- DOI
  10.1016/j.archoralbio.2015.11.015
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K11389, KAKENHI-PROJECT-15K11390, KAKENHI-PROJECT-15K15766
[Journal Article] Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice.2016
- Author(s)
  Yamakawa M, Ouhara K, Kajiya M, Munenaga S, Kittaka M, Yamasaki S, Takeda K, Takeshita K, Mizuno N, Fujita T, Sugiyama E, Kurihara H.
- Journal Title
  
  Clin Exp Immunol
  
  Volume: Nov;186(2): Pages: 177-189
- DOI
  10.1111/cei.12847
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15766, KAKENHI-PROJECT-16K20672, KAKENHI-PROJECT-15K11390
[Journal Article] The differential expression of mgl mRNA by Porphyromonas gingivalis affects the production of methyl mercaptan.2015
- Author(s)
  Ouhara Kazuhisa
- Journal Title
  
  Oral Dis.
  
  Volume: Feb 23
- DOI
  10.1111/odi.12326
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25862051
[Journal Article] Clumps of a mesenchymal stromal cell/extracellular matrix complex can be a novel tissue engineering therapy for bone regeneration2015
- Author(s)
  Kittaka M, Kajiya M, Shiba H, Takewaki M, Takeshita K, Khung R, Fujita T, Iwata T, Nguyen TQ, Ouhara K, Takeda K, Fujita T, Kurihara H.
- Journal Title
  
  Cytotherapy
  
  Volume: 2 Pages: 00048-1
- DOI
  10.1016/j.jcyt.2015.01.007
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390467, KAKENHI-PROJECT-25862051, KAKENHI-PROJECT-26861814, KAKENHI-PROJECT-15H05053, KAKENHI-PROJECT-24593122
[Journal Article] BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade.2014
- Author(s)
  Mikihito Kajiya, Kei Takeshita, Mizuho Kittaka, Shinji Matsuda, Kazuhisa Ouhara, Katsuhiro Takeda, Takashi Takata, Masae Kitagawa, Tsuyoshi Fujita, Hideki Shiba, Hidemi Kurihara
- Journal Title
  
  International Immunopharmacology
  
  Volume: 19(2) Pages: 245-252
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390467
[Journal Article] 9. Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice.2013
- Author(s)
  FurushoH,Miyauchi M,Hyogo H,Inubushi T,Ao M,Ouhara K,Hisatune J,Kurihara H,Sugai M,Hayes CN,Nakahara T,Akikata H,Takahashi S,Chayama K,Takata T
- Journal Title
  
  J Gastroenterol.
  
  Volume: 48(11) Pages: 1259-70
- DOI
  10.1007/s00535-012-0738-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890138, KAKENHI-PROJECT-25462855, KAKENHI-PROJECT-25862051
[Journal Article] miR-584 Expressed in Human Gingival Epithelial Cells is Induced by Porphyromonas Gingivalis Stimulation and Regulates Interleukin-8 Production via Lactoferrin Receptor.2013
- Author(s)
  Ouhara K, Savitri IJ, Fujita T, Kittaka M, Kajiya M, Iwata T, Miyagawa T, Yamakawa M, Shiba H, Kurihara H.
- Journal Title
  
  J Periodontol.
  
  Volume: Nov 14.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25862051
[Journal Article] Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans2013
- Author(s)
  Miyagawa T
- Journal Title
  
  International Immunopharmacology
  
  Volume: 15 Pages: 340-347
- DOI
  10.1016/j.intimp.2012.12.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390497, KAKENHI-PROJECT-22792085, KAKENHI-PROJECT-24593123, KAKENHI-PROJECT-24792330
[Journal Article] Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice2013
- Author(s)
  Furusho H, Miyauchi M, Hyogo H, Inubushi T, Ao M, OuharaK, Hisatune J, Kurihara H, Sugai M, Hayes CN, Nakahara T, Aikata H, Takahashi S, Chayama K, Takata T
- Journal Title
  
  J Gastroenterol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22792085
[Journal Article] The antimicrobial peptide LL37 promotes bone regeneration in a rat calvarial bone defect.2013
- Author(s)
  Kittaka M., Shiba H., Kajiya M., Fuita T., Iwata T., Rathvisa K., Ouhara K., Takeda K., Fujita T., Komatsuzawa H., Kurihara, H.
- Journal Title
  
  Peptides.
  
  Volume: 46 Pages: 136-42
- DOI
  10.1016/j.peptides.2013.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24593122, KAKENHI-PROJECT-25862051
[Journal Article] Expression levels of novel cytokine IL-32 in periodontitis and its role in the suppression of IL-8 production by human gingival fibroblasts stimulated with Porphyromonas gingivalis.2012
- Author(s)
  Ouhara K, Kawai T, Silva MJ, Fujita T, Hayashida K, Karimbux NY, Kajiya M, Shiba H, Kawaguchi H, Kurihara H
- Journal Title
  
  J Oral Microbiol.
  
  Volume: 4
- DOI
  10.3402/jom.v4i0.14832
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] 歯周病原細菌に対する歯周組織局所の免疫応答が及ぼす全身疾患への影響2020
- Author(s)
  應原　一久
- Organizer
  日本歯周病学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K09599
[Presentation] 関節リウマチ患者由来抗シトルリン化ペプチド抗体を用いた破骨細胞分化抑制作用について2019
- Author(s)
  應原　一久、宗永　修一、平田　信太郎、杉山　英二、栗原　英見
- Organizer
  第63回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K09599
[Presentation] The localization of ACPA derived from RA patient in periodontal tissue of mouse periodontitis model2018
- Author(s)
  應原　一久
- Organizer
  第６２回　日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K09599
[Presentation] A human ACPA monoclonal antibody is preferably localized at inflammatory gingival tissue and activates osteoclastogenensis in Porphyromonas gingivalis infected SKG mouse2018
- Author(s)
  Kazuhisa Ouhara
- Organizer
  2018 american collage of rheumatology annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09599
[Presentation] コウボクはPorphyromonas gingivalisのmglを介したメチルメルカプタン産生を抑制する2016
- Author(s)
  佐藤陽子、應原一久　宗永修一　加冶屋幹人　水野智仁　藤田剛　栗原英見
- Organizer
  日本歯科保存学会２０１６年度秋季学術大会（第１４５回）
- Place of Presentation
  長野県松本市
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-15K15766
[Presentation] Porphyromonas gingivalis infection exacerbates rheumatoid arthritis in mice model.2016
- Author(s)
  山川真宏、應原一久　高田隆、　栗原英見
- Organizer
  国際歯科学会（韓国　ソウル）
- Place of Presentation
  ソウル、大韓民国
- Year and Date
  2016-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11390
[Presentation] 歯周病原細菌Porphyromonas gingivalis感染の関節リウマチへの影響についての検討2016
- Author(s)
  宗永修一、應原一久　山川真宏　山崎聡士　杉山英二　栗原英見
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  横浜市
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15K11390
[Presentation] 歯周病原細菌Porphyromonas gingivalis感染の関節リウマチへの影響についての検討2016
- Author(s)
  宗永修一、應原一久　山川真宏　山崎聡士　杉山英二　栗原英見
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  横浜市
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15K15766
[Presentation] Porphyromonas gingivalis infection exacerbates rheumatoid arthritis in mice model.2016
- Author(s)
  山川真宏、應原一久　高田隆、　栗原英見
- Organizer
  国際歯科学会（韓国　ソウル）
- Place of Presentation
  ソウル、大韓民国
- Year and Date
  2016-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15766
[Presentation] 骨髄間葉系幹細胞集塊Clumps of mesenchymal stem cells/extracellular matrix complexを利用した新規組織再生療法開発2014
- Author(s)
  加治屋幹人、橘高瑞穂、柴　秀樹、竹脇　学、竹下　慶、岩田倫幸、應原一久、武田克浩、
- Organizer
  第57回秋季日本歯周病学会学術大会
- Place of Presentation
  神戸市
- Year and Date
  2014-10-19
- Data Source
  KAKENHI-PROJECT-24390467
[Presentation] 歯周組織における neonatal Fc receptor を介した歯周病原細菌由来免疫複合体の能動輸送2014
- Author(s)
  應原一久
- Organizer
  第８７回日本細菌学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25862051
[Presentation] 嚢胞様根尖病巣由来滲出液中のサイトカイン産生量プロファイリング2012
- Author(s)
  應原一久
- Organizer
  第5回日本口腔検査学会総会・学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] 嚢胞様根尖病巣由来滲出液中のサイトカイン産生量プロファイリング2012
- Author(s)
  應原　一久
- Organizer
  第５回日本口腔検査学会総会・学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] 嚢胞様根尖病巣由来滲出液中のサイトカイン産生量プロファイリング2012
- Author(s)
  應原　一久
- Organizer
  第51回広島県歯科医学会・第96回広島大学歯学会
- Place of Presentation
  広島市
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] 嚢胞様根尖病巣に対する選択的抗菌薬療法2012
- Author(s)
  應原　一久
- Organizer
  第22回日本歯科医学会総会
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] 根尖病変を「宿主－寄生体相互作用」の概念から捉えた新しい検査・治療法の確立2012
- Author(s)
  應原　一久
- Organizer
  日本歯科保存学会　2012秋季学術大会（第137回）
- Place of Presentation
  広島市
- Invited
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] 広島大学病院歯周診療科・口臭外来における口臭検査　－平成22－23年度受診患者の傾向－2012
- Author(s)
  應原　一久
- Organizer
  日本歯周病学会　第7回　中国地区臨床研修会
- Place of Presentation
  松江市
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] ヒト歯肉上皮細胞におけるPorphyromonas gingivalis刺激時のmicroRNA発現の網羅的解析2012
- Author(s)
  應原　一久
- Organizer
  日本歯周病学会　2012秋季学術大会
- Place of Presentation
  つくば市
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] ヒト末梢血単核球におけるIL-32の破骨細胞への影響2011
- Author(s)
  應原一久
- Organizer
  第134回日本歯科保存学会学術大会
- Place of Presentation
  浦安市
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] 炎症性サイトカインIL-32の歯周組織における発現およびPBMCに対する作用2010
- Author(s)
  應原一久
- Organizer
  第53回日本歯周病学会学術大会
- Place of Presentation
  盛岡市
- Year and Date
  2010-05-15
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] Molecular analysis of Omp29-like pathogenic antigen from P.pneumotropica in mouse periodontitis2010
- Author(s)
  應原一久
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  横浜市
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-21890165
[Presentation] The-break-of-immunetolerance to oral-commensal-bacteria leads to periodontal bone loss in mouse2010
- Author(s)
  應原一久
- Organizer
  International Assiciation of Dental Research
- Place of Presentation
  Balcerona, Spain
- Year and Date
  2010-07-17
- Data Source
  KAKENHI-PROJECT-22792085
[Presentation] 広島大学病院口腔検査センターにおけるPorphyromonas gingivalisに対する血清抗体価検査
- Author(s)
  應原一久
- Organizer
  第７回日本口腔検査学会総会・学術大会
- Place of Presentation
  岡山市
- Year and Date
  2014-09-06 – 2014-09-07
- Data Source
  KAKENHI-PROJECT-25862051
[Presentation] The molecular analysis of Rheumatoid Arthritis-related gene LRG1 in periodontitis
- Author(s)
  應原一久
- Organizer
  International association of dental research
- Place of Presentation
  アメリカ合衆国　ボストン
- Year and Date
  2015-03-11 – 2015-03-14
- Data Source
  KAKENHI-PROJECT-25862051
[Presentation] 歯周病原細菌Porphyromonas gingivalis 感染の全身疾患への影響
- Author(s)
  應原一久
- Organizer
  無菌生物ノートバイオロジー学会総会
- Place of Presentation
  広島市
- Year and Date
  2015-01-30 – 2015-01-31
- Invited
- Data Source
  KAKENHI-PROJECT-25862051

1. KURIHARA HIDEMI (40161765)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
2. 藤田剛 (80379883)

# of Collaborated Projects: 3 results

# of Collaborated Products: 26 results
3. 小澤龍彦 (10432105)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. 杉山英二 (70179167)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
5. UCHIDA Yuushi (40363080)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 宮内睦美 (50169265)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. KATO Kouichi (50283875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MIZUNO Noriyoshi (60325181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. IWATA Tomoyuki (30418793)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
10. 二川浩樹 (10228140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 向下寿子 (00634461)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 中野由紀子 (10397911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 作村諭一 (50324968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 小松澤均 (90253088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 新谷智章 (90403518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 柴秀樹 (60260668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. 武田克浩 (10452591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 松尾美樹 (20527048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 丸山博文 (90304443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 北川雅恵 (10403627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 長嶺憲太郎 (80412352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. FURUSHO Hisako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. INUBUSHI Toshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. MIKIHITO Kajiya

# of Collaborated Projects: 0 results

# of Collaborated Products: 11 results
25. Komatsu Nao

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. MIYAGAWA TSUYOSHI

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. YOSHIMOTO TETSUYA

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
28. IKEYA Makoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. TAKEDA Katsuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
30. AKUTAGAWA KEIICHI

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. TAKEMURA TASUKU

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. HIRATA Shintaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. Sasaki Shinya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 兵庫秀幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 高田隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 宗永修一

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
37. 松田真司

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
38. 松田由喜子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
39. 川上秀史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 岸裕幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
41. 庄子幹郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 中山浩次

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 濱本結太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ouhara Kazuhisa 應原 一久

OUHARA Kazuhisa 應原 一久

Research Projects

Research Products

Co-Researchers

関節リウマチ患者由来ACPAと歯周病原菌関連タンパクによる歯周組織破壊機序の解明Principal Investigator

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The induced RNA-binding protein, HuR targets of IL-6 mRNA and enhances its stabilization in periodontitisPrincipal Investigator

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The bidirectional effect of Leucine-rich alpha-2-glycoprotein 1 (LRG1) in rheumatoid arthritis and periodontitisPrincipal Investigator

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The effect of PAD derived from periodontopathogenic bacteria in rheumatoid arthritisPrincipal Investigator

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The analysis and application for periodontal treatment of FcRn which is tha passive IgG transporter in epithelial cellsPrincipal Investigator

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上皮細胞が産生するIgG能動輸送タンパク質FcRnによる歯周炎治療法の開発Principal Investigator

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Ouhara Kazuhisa 應原一久

OUHARA Kazuhisa 應原一久