OTSUBO Ryota 大坪竜太

Researcher Number	80570043
Other IDs
Affiliation (Current)	2025: 長崎大学, 病院(医学系), 教授
Affiliation (based on the past Project Information) *help	2025: 長崎大学, 病院(医学系), 教授 2023: 長崎大学, 病院(医学系), 准教授 2020 – 2023: 長崎大学, 病院(医学系), 講師 2015 – 2019: 長崎大学, 病院(医学系), 助教 2014: 長崎大学, 産学官連携戦略本部, 助教
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / General surgery Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / General surgery
Keywords	Principal Investigator 乳癌 / 術前薬物療法 / Semi-dry dot-blot / リンパ節転移 / 臨床性能試験 / サイトケラチン19蛋白 / サイトケラチン / Image-guided surgery / 蛍光色素 / 近赤外線 … More / HER2陽性 / image-guided surgery / 癌 / 甲状腺 / 病理学 / Semi-dry dot-blot法 / 甲状腺乳頭癌 … More Except Principal Investigator mutation analysis / copy number anlaysis / copy number analysis / 次世代シークエンス / トランスレーショナルリサーチ / リキッドバイオプシー / 乳がん / 次世代シークエンサー / Liquid Biopsy / circulating tumor DNA / 乳癌 / 甲状腺濾胞癌 / 核内フォーカス / p53 binding protein 1 / 術前診断 / 濾胞癌 / 53BP1核内フォーカス / 術前細胞診診断 / 甲状腺濾胞性腫瘍 Less

新規乳癌リンパ節転移診断キットの術前薬物療法症例における臨床性能試験Principal Investigator
- Principal Investigator
  
  大坪竜太
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Nagasaki University
Expanding of indication about the new diagnostic kit to detect lymph node metastases for breast cancer patients with preoperative systemic therapyPrincipal Investigator
- Principal Investigator
  
  大坪竜太
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Nagasaki University
Exploration of Novel Diagnostic and Therapeutic Approaches for Breast Cancer Using an Innovative Liquid Biopsy Method
- Principal Investigator
  
  OIKAWA Masahiro
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Nagasaki University
Tracer search in image-guided surgery of HER2-positive breast cancerPrincipal Investigator
- Principal Investigator
  
  Otsubo Ryota
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Nagasaki University
Development of a novel diagnostic kit to detect lymph nodes in thyroid papillary carcinomaPrincipal Investigator
- Principal Investigator
  
  OTSUBO Ryota
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Nagasaki University
Immunofluorescence analysis of P53-binding protein 1 in thyroid follicular tumours
- Principal Investigator
  
  YANO Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Nagasaki University

All 2024 2021 2019 2018 2017 2016 2014

All Journal Article Presentation

[Journal Article] Protocol for studying the efficiency of ChemoCalc software in helping patients to understand drug treatment costs for breast cancer: A multicenter, open-label, randomized phase 2 study2021
- Author(s)
  Kuba Sayaka、Moriuchi Hiroki、Yamanouchi Kosho、Shibata Kenichiro、Yano Hiroshi、Oikawa Masahiro、Maeda Shigeto、Meng Xiangyue、Morita Michi、Hatachi Toshiko、Otsubo Ryota、Matsumoto Megumi、Miyamoto Junya、Kanetaka Kengo、Taniguchi Hideki、Nagayasu Takeshi、Eguchi Susumu
- Journal Title
  
  Contemporary Clinical Trials Communications
  
  Volume: 21 Pages: 100739-100739
- DOI
  10.1016/j.conctc.2021.100739
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09075
[Journal Article] A novel diagnostic method for thyroid follicular tumors based on immunofluorescence analysis of p53-binding protein 1 expression: detection of genomic instability2019
- Author(s)
  Otsubo Ryota、Matsuda Katsuya、Mussazhanova Zhanna、Sato Ayako、Matsumoto Megumi、Yano Hiroshi、Oikawa Masahiro、Kondo Hisayoshi、Ito Masahiro、Miyauchi Akira、Hirokawa Mitsuyoshi、Nagayasu Takeshi、Nakashima Masahiro
- Journal Title
  
  Thyroid
  
  Volume: 印刷中 Issue: 5 Pages: 657-665
- DOI
  10.1089/thy.2018.0548
- NAID
  120006987702
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16KK0204, KAKENHI-PROJECT-19K07471, KAKENHI-PROJECT-19K09075
[Journal Article] Validation of a Novel Diagnostic Kit Using the Semidry Dot-Blot Method to Detect Metastatic Lymph Nodes in Breast Cancer: Distinguishing Macrometastases From Nonmacrometastases.2018
- Author(s)
  Ryota Otsubo
- Journal Title
  
  Clinical Breast Cancer
  
  Volume: 18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10461
[Journal Article] Validation of a Novel Diagnostic Kit Using the Semidry Dot-Blot Method to Detect Metastatic Lymph Nodes in Breast Cancer: Distinguishing Macrometastases From Nonmacrometastases.2017
- Author(s)
  Ryota Otsubo
- Journal Title
  
  Clinical breast cancer
  
  Volume: 17 Issue: 3 Pages: e345-e351
- DOI
  10.1016/j.clbc.2017.07.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10461, KAKENHI-PROJECT-16KK0204, KAKENHI-PROJECT-15K19865
[Presentation] Semi-dry dot-blot（SDB）法を応用した新規乳癌リンパ節転移診断キットの術前薬物療法症例への適応拡大2024
- Author(s)
  大坪竜太
- Organizer
  第124回日本外科学会定期学術集会（サージカルフォーラム）
- Data Source
  KAKENHI-PROJECT-22K08695
[Presentation] Unbiased copy number analysis of circulating tumor DNA among HER2-positive breast cancer patients2019
- Author(s)
  Masahiro Oikawa, Yasuko Enomoto, Kazuhumi Hisamatsu, Tetsuo Hamada, Ryota Otsubo, Hiroshi Yano, Takeshi Nagayasu, Hiroyuki Mishima, Koh-ichiro Yoshiura and Nicholas Navin
- Organizer
  2019 San Antonio Breast Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09075
[Presentation] PEGASUS (Plasma Exome and Genome Analysis by Size-Selection and Unbiased Sequencing) を用いた乳癌のリキッドバイオプシー研究2019
- Author(s)
  及川将弘、榎本康子、久松和史、及川達司、濵田哲夫、大坪竜太、矢野洋、永安武、Nicholas E Navin
- Organizer
  2019年度日本乳癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09075
[Presentation] 乳癌患者における血漿遊離DNA (cfDNA)濃度と血漿循環腫瘍DNA (ctDNA)の解析2019
- Author(s)
  及川将弘、瀬戸口優美香、榎本康子、久松和史、及川達司、濵田哲夫、大坪竜太、松本恵、矢野洋、永安武、三嶋博之、木下晃、吉浦孝一郎
- Organizer
  2019年度日本人追遺伝学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09075
[Presentation] Validation of novel diagnostic kits using the semi-dry dot-blot method for detecting metastatic lymph nodes in breast cancer; distinguishing macrometastases and micrometastases2016
- Author(s)
  Ryota Otsubo
- Organizer
  San Antonio Breast Cancer Symposium 2016
- Place of Presentation
  San Antonio, Texas, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10461
[Presentation] 甲状腺濾胞性腫瘍診断におけるp53 binding protein 1（53BP1）核内フォーカスとアレイCGH解析2014
- Author(s)
  大坪竜太
- Organizer
  第47回日本甲状腺外科学会学術集会
- Place of Presentation
  アクロス福岡（福岡市）
- Year and Date
  2014-10-30
- Data Source
  KAKENHI-PROJECT-26461951
[Presentation] Immunofluorescence analysis of p53-binding protein 1 in thyroid follicular tumors: possibility for preoperative diagnosis2014
- Author(s)
  大坪竜太
- Organizer
  European Congress of Pathology 2014
- Place of Presentation
  ExCeL London（UK）
- Year and Date
  2014-09-01
- Data Source
  KAKENHI-PROJECT-26461951

1. 永安武 (80284686)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. YANO Hiroshi (50380887)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. 中島正洋 (50284683)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 田中彩 (50893244)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. OIKAWA Masahiro (90612416)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. 馬場雅之 (90771957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 三嶋博之 (10513319)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 松本恵 (90404269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 山口倫 (10309750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 柳原克紀 (40315239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 原勇紀 (40978300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 松本桂太郎 (80404268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OTSUBO Ryota 大坪 竜太

Research Projects

Research Products

Co-Researchers

新規乳癌リンパ節転移診断キットの術前薬物療法症例における臨床性能試験Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Expanding of indication about the new diagnostic kit to detect lymph node metastases for breast cancer patients with preoperative systemic therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of Novel Diagnostic and Therapeutic Approaches for Breast Cancer Using an Innovative Liquid Biopsy Method

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Tracer search in image-guided surgery of HER2-positive breast cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel diagnostic kit to detect lymph nodes in thyroid papillary carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immunofluorescence analysis of P53-binding protein 1 in thyroid follicular tumours

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Protocol for studying the efficiency of ChemoCalc software in helping patients to understand drug treatment costs for breast cancer: A multicenter, open-label, randomized phase 2 study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel diagnostic method for thyroid follicular tumors based on immunofluorescence analysis of p53-binding protein 1 expression: detection of genomic instability2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Validation of a Novel Diagnostic Kit Using the Semidry Dot-Blot Method to Detect Metastatic Lymph Nodes in Breast Cancer: Distinguishing Macrometastases From Nonmacrometastases.2018

Author(s)

Journal Title

Data Source

[Journal Article] Validation of a Novel Diagnostic Kit Using the Semidry Dot-Blot Method to Detect Metastatic Lymph Nodes in Breast Cancer: Distinguishing Macrometastases From Nonmacrometastases.2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Semi-dry dot-blot（SDB）法を応用した新規乳癌リンパ節転移診断キットの術前薬物療法症例への適応拡大2024

Author(s)

Organizer

Data Source

[Presentation] Unbiased copy number analysis of circulating tumor DNA among HER2-positive breast cancer patients2019

Author(s)

Organizer

Data Source

[Presentation] PEGASUS (Plasma Exome and Genome Analysis by Size-Selection and Unbiased Sequencing) を用いた乳癌のリキッドバイオプシー研究2019

Author(s)

Organizer

Data Source

[Presentation] 乳癌患者における血漿遊離DNA (cfDNA)濃度と血漿循環腫瘍DNA (ctDNA)の解析2019

Author(s)

Organizer

Data Source

[Presentation] Validation of novel diagnostic kits using the semi-dry dot-blot method for detecting metastatic lymph nodes in breast cancer; distinguishing macrometastases and micrometastases2016

Author(s)

Organizer

Place of Presentation

OTSUBO Ryota 大坪竜太