HARADA Yuichiro 原田裕一郎

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Harada Yuichirou 原田裕一郎

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Researcher Number	80570168
Other IDs
Affiliation (Current)	2025: 東京医科大学, 医学部, 助手 2025: 国立研究開発法人国立成育医療研究センター, 細胞医療研究部, 共同研究員
Affiliation (based on the past Project Information) *help	2013 – 2024: 東京医科大学, 医学部, 助手 2012: 独立行政法人国立成育医療研究センター, その他部局等, その他
Review Section/Research Field	Principal Investigator Experimental pathology / Obstetrics and gynecology Except Principal Investigator Basic Section 49030:Experimental pathology-related / Basic Section 56040:Obstetrics and gynecology-related / Experimental pathology
Keywords	Principal Investigator 新規構造RNA / miRNA / マイクロRNA / small RNA / RNA干渉 / Ca2+シグナル / クエン酸合成酵素 / Citrate synthase-like / 卵活性化 / Citrate Synthase-like / Ca2+濃度上昇 / 受精 … More Except Principal Investigator … More microRNA / miRNA / 核酸医薬 / mouse model / DICER1 / TNRC6 / AGO / CDK9 / DDX21 / RNA pol II pausing / RNA activation / ESR1 / 子宮頸癌予防 / 子宮頸癌 / MACROD1 / CIN / WAPL / ノンコーディングRNA / ヘアピンRNA / RNA干渉 / Non-coding RNA / RNA interference / 炎症性サイトカイン / 肺がん / miR-34a Less

Development of DICER1 syndrome model mice
- Principal Investigator
  
  大野慎一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Tokyo Medical University
Analysis of molecular mechanisms in RNA activation
- Principal Investigator
  
  Ohno Shinichiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Tokyo Medical University
Development of a Novel Preventive Method for Cervical Cancer
- Principal Investigator
  
  Kumagai Katsuyoshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  University of Human Arts and Sciences
  Tokyo Medical University
Exploration and functional analysis of novel RNA-interfering nucleic acids.
- Principal Investigator
  
  Ohno Shin-ichiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Tokyo Medical University
Analysis for functions of novel small RNAs in the gene expressionPrincipal Investigator
- Principal Investigator
  
  Harada Yuichirou
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Medical University
Development of novel form of mimic microRNA for microRNA replacement therapy.
- Principal Investigator
  
  OHNO Shinichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Medical University
Elucidation of new ca2+-releasing molecule and its mechanism for infertility treatmentPrincipal Investigator
- Principal Investigator
  
  Harada Yuichirou
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Tokyo Medical University
  National Research Institute for Child Health and Development

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2012

All Journal Article Presentation

[Journal Article] Nuclear microRNAs release paused Pol II via the DDX21-CDK9 complex2022
- Author(s)
  Shin-Ichiro Ohno, Keiki Oikawa, Toshiaki Tsurui, Yuichirou Harada, Kana Ono, Mizumo Tateishi, Aashiq Mirza, Masakatsu Takanashi, Kosuke Kanekura, Kumiko Nagase, Yoshihisa Shimada, Yujin Kudo, Norihiko Ikeda, Takahiro Ochiya, Xiaozhong Wang , Masahiko Kuroda
- Journal Title
  
  Cell Reports
  
  Volume: 12;39(2) Issue: 2 Pages: 110673-110673
- DOI
  10.1016/j.celrep.2022.110673
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06953, KAKENHI-PROJECT-20H03593, KAKENHI-PROJECT-21H02706
[Journal Article] WAPL induces cervical intraepithelial neoplasia modulated with estrogen signaling without HPV E6/E7. Oncogene.2021
- Author(s)
  Kumagai K, Takanashi M, Ohno SI, Harada Y, Fujita K, Oikawa K, Sudo K, Ikeda　SI, Nishi H, Oikawa K, Kuroda M.
- Journal Title
  
  Oncogene
  
  Volume: 40(21) Issue: 21 Pages: 3695-3706
- DOI
  10.1038/s41388-021-01787-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08382, KAKENHI-PROJECT-21H02706, KAKENHI-PROJECT-20K09654
[Journal Article] rAAV6-mediated miR-29b delivery suppresses renal fibrosis.2019
- Author(s)
  Saito S, Ohno SI, Harada Y, Oikawa K, Fujita K, Mineo S, Gondo A, Kanno Y, KurodaM.
- Journal Title
  
  Clin Exp Nephrol.
  
  Volume: 23 (12) Issue: 12 Pages: 1345-1356
- DOI
  10.1007/s10157-019-01783-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07048, KAKENHI-PROJECT-17H04067, KAKENHI-PROJECT-17K10564, KAKENHI-PROJECT-17K16101
[Journal Article] Development of novel small hairpin RNAs that do not require processing by dicer or AGO22016
- Author(s)
  Ohno S, Itano K, Harada Y, Asada K, Oikawa K, Kashiwazako M, Okuyama H, Kumagai K, Takanashi M, Sudo K, Ikeda N, Kuroda M.
- Journal Title
  
  Mol Ther
  
  Volume: 24 Issue: 7 Pages: 1278-1289
- DOI
  10.1038/mt.2016.81
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26250029, KAKENHI-PROJECT-26293088, KAKENHI-PROJECT-26461961, KAKENHI-PROJECT-15K15100, KAKENHI-PROJECT-15K08410, KAKENHI-PROJECT-16K09376
[Journal Article] Mitochondrial dynamics controlled by mitofusins define organelle positioning and movement during mouse oocyte maturation2014
- Author(s)
  Takuya Wakai, Yuichirou Harada, Kenji Miyado, Tomohiro Kono
- Journal Title
  
  Molecular Human Reproduction
  
  Volume: 20 Issue: 11 Pages: 1090-1100
- DOI
  10.1093/molehr/gau064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24791731, KAKENHI-PROJECT-26293363, KAKENHI-PROJECT-26670733
[Journal Article] Egg activation in physiologically polyspermic newt eggs: involvement of IP3 receptor, PLCγ, and microtubules in calcium wave induction2014
- Author(s)
  Tomoyo Ueno, Takehiro Ohgami, Yuichirou Harada, Shuichi Ueno, Yasuhiro Iwao
- Journal Title
  
  The International Journal of Developmental Biology
  
  Volume: 58 Issue: 5 Pages: 315-323
- DOI
  10.1387/ijdb.130333yi
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791731
[Presentation] Liver-specific DICER1 syndrome model mouse develops cystic liver tumor.2023
- Author(s)
  大野慎一郎、原田裕一郎、黒田雅彦
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21K06953
[Presentation] Liver-specific DICER1 syndrome model mouse develops congenital hepatic fibrosis and Caroli’s syndrome2023
- Author(s)
  大野慎一郎、原田裕一郎、黒田雅彦
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06953
[Presentation] A mouse model of DICER1 syndrome develops cirrhosis, bile duct hyperplasia and hepatic tumors2022
- Author(s)
  大野慎一郎、原田裕一郞、黒田雅彦
- Organizer
  第８１回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06953
[Presentation] A mouse model of DICER1 syndrome develops hepatic mesenchymal hamartoma.2022
- Author(s)
  大野慎一郎、原田裕一郞、黒田雅彦
- Organizer
  第１１１回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21K06953
[Presentation] Model mice that mimic the genotype of DICER1 syndrome develop hepatic mesenchymal hamartoma.2021
- Author(s)
  大野慎一郎、原田裕一郞、黒田雅彦
- Organizer
  第１１０回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21K06953
[Presentation] miR-34-AGO-TNRC6A complex transcriptionally up-regulates BLU tumor suppressor via binding of a novel promoter-associated lncRNA in lung cancer2020
- Author(s)
  Shin-ichiro Ohno, Keiki Oikawa, Yuichirou Harada, Masahiko Kuroda
- Organizer
  AACR Annual Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07048
[Presentation] miR-34-AGO complex transcriptionally up-regulate BLU tumor suppressor via binding of novel lncRNA2020
- Author(s)
  大野慎一郎、老川桂生、原田裕一郞、黒田雅彦
- Organizer
  第１０９回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K07048
[Presentation] Development of novel nucleic acid drug targeting KRAS to suppress lung cancer2020
- Author(s)
  Shin-ichiro Ohno, Yuichirou Harada, Masahiko Kuroda
- Organizer
  第７９回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07048
[Presentation] miR-34 familyによる3p21.3領域に存在するがん抑制遺伝子の発現誘導2019
- Author(s)
  大野慎一郎、老川桂生、原田裕一郎、黒田雅彦
- Organizer
  第１０８回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K07048
[Presentation] The novel lncRNA expressed from the promoter of tumor suppressor BLU induces BLU expression via the miR-34-AGO complex.2019
- Author(s)
  大野慎一郎、老川桂生、原田裕一郎、黒田雅彦
- Organizer
  第７８回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07048
[Presentation] Up-regulation pf BLU tumor suppressor by miR-34a2018
- Author(s)
  大野慎一郎、三部　芳裕、弓野　梨紗、老川桂生、原田裕一郎、黒田雅彦
- Organizer
  第１０回日本RNAi研究会
- Data Source
  KAKENHI-PROJECT-18K07048
[Presentation] miR-34によるがん抑制遺伝子BLUの発現誘導2018
- Author(s)
  大野慎一郎、老川桂生、原田裕一郎、黒田雅彦
- Organizer
  第１０７回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K07048
[Presentation] miR-34によるがん抑制遺伝子BLUの発現誘導2018
- Author(s)
  大野慎一郎、老川桂生、原田裕一郎、黒田雅彦
- Organizer
  第７７回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-18K07048
[Presentation] RNA干渉に働く短鎖ヘアピンＲＮＡの探索と機能解析2017
- Author(s)
  大野慎一郎、原田裕一郎、村上善基、黒田雅彦
- Organizer
  第１０６回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-15K08410
[Presentation] Search and characterization of novel hairpin RNAs acting on RNA interference2017
- Author(s)
  大野慎一郎、原田裕一郎、村上善基、黒田雅彦
- Organizer
  第６回医薬工シンポジウム
- Data Source
  KAKENHI-PROJECT-15K08410
[Presentation] Mir-34aによるがん抑制遺伝子BLUの発現制御機構2017
- Author(s)
  大野慎一郎、三部芳裕、弓野梨紗、老川桂生、原田裕一郞、黒田雅彦
- Organizer
  第７６回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K08410
[Presentation] Development of novel Dicer- and Ago2-independent small hairpin RNAs.2016
- Author(s)
  Shin-ichiro OHNO, Karen ITANO, Yuichirou HARADA, Koutaro ASADA, Keiki OIKAWA, Mikie KASHIWAZAKO, Hikaru OKUYAMA, Katsuyoshi KUMAGAI, Masakatsu TAKANASHI, Katsuko SUDO, Norihiko IKEDA, Masahiko KURODA.
- Organizer
  ASGCT 19th Annual Meeting 2016
- Place of Presentation
  Marriott Wardman Park, Washington, DC, USA.
- Year and Date
  2016-05-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08410
[Presentation] 肺がん治療を想定した副作用の少ない短鎖型新規核酸医薬の開発2015
- Author(s)
  大野慎一郎、板野華連、原田裕一郎、浅田浩太朗、老川桂生、柏迫幹絵、高梨正勝、須藤カツ子、池田徳彦、黒田雅彦
- Organizer
  第１０４回日本病理学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-15K08410
[Presentation] マウス卵の受精におけるクエン酸合成酵素による卵活性化の可能性2012
- Author(s)
  原田　裕一郎、岩尾　康宏、宮戸　健二
- Organizer
  日本動物学会第83回大会
- Place of Presentation
  大阪府豊中市大阪大学
- Data Source
  KAKENHI-PROJECT-24791731

1. OHNO Shinichiro (90513680)

# of Collaborated Projects: 5 results

# of Collaborated Products: 20 results
2. Kumagai Katsuyoshi (20567911)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
3. 黒田雅彦 (80251304)

# of Collaborated Projects: 4 results

# of Collaborated Products: 21 results
4. 須藤カツ子 (50126091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 西洋孝 (60307345)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 高梨正勝 (80312007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

HARADA Yuichiro 原田 裕一郎

Harada Yuichirou 原田 裕一郎

Research Projects

Research Products

Co-Researchers

Development of DICER1 syndrome model mice

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of molecular mechanisms in RNA activation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a Novel Preventive Method for Cervical Cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration and functional analysis of novel RNA-interfering nucleic acids.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis for functions of novel small RNAs in the gene expressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel form of mimic microRNA for microRNA replacement therapy.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of new ca2+-releasing molecule and its mechanism for infertility treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Nuclear microRNAs release paused Pol II via the DDX21-CDK9 complex2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] WAPL induces cervical intraepithelial neoplasia modulated with estrogen signaling without HPV E6/E7. Oncogene.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] rAAV6-mediated miR-29b delivery suppresses renal fibrosis.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of novel small hairpin RNAs that do not require processing by dicer or AGO22016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitochondrial dynamics controlled by mitofusins define organelle positioning and movement during mouse oocyte maturation2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Egg activation in physiologically polyspermic newt eggs: involvement of IP3 receptor, PLCγ, and microtubules in calcium wave induction2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] Liver-specific DICER1 syndrome model mouse develops cystic liver tumor.2023

Author(s)

Organizer

HARADA Yuichiro 原田裕一郎

Harada Yuichirou 原田裕一郎