YAMAMOTO HIROYUKI 山本浩之

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Yamamoto Hiroyuki 山本浩之

YAMAMOTO Hiroyuki 山本浩之

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Researcher Number	80574615
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所エイズ研究センター, センター長
Affiliation (based on the past Project Information) *help	2025: 国立健康危機管理研究機構, エイズ研究センター, センター長 2024: 国立感染症研究所, エイズ研究センター, センター長 2018 – 2020: 国立感染症研究所, エイズ研究センター, グループ長 2017 – 2019: 国立感染症研究所, エイズ研究センター, 室長 2014: 国立感染症研究所, その他部局等, その他 … More 2014: 国立感染症研究所, エイズ研究センター, グループ長 2013: 国立感染症研究所, その他部局等, グループ長 2011: 国立感染症研究所, エイズ研究センター, 研究員 2010: 東京大学, 医科学研究所, 特任研究員 Less
Review Section/Research Field	Principal Investigator Virology / Basic Section 49030:Experimental pathology-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Basic Section 49060:Virology-related Except Principal Investigator Applied health science
Keywords	Principal Investigator 免疫シグナル伝達 / B細胞 / エイズ / 中和抗体 / SIV / HIV / 疾患表現型 / DNA ligase 4 / IEI / 先天性免疫不全疾患 … More / ヒト免疫不全ウイルス / 形態学パラメータ / シングルセル画像解析 / ウイルス潜伏感染 / 持続感染ウイルス / Env / CTL / 遺伝子 / ゲノム / 動物 / 感染症 / ウイルス … More Except Principal Investigator HIV感染症 / 慢性ウイルス感染 / DNAメチル化 / HIV / T細胞 / エピジェネティクス / 感染症 / 免疫老化 Less

ウイルス易感受性を来す新たな成人発症型IEI（先天性免疫不全疾患）の病態解析Principal Investigator
- Principal Investigator
  
  山本浩之
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Japan Institute for Health Security
シングルセル画像特徴量への「翻訳」によるウイルス潜伏感染の定義・発見・排除Principal Investigator
- Principal Investigator
  
  山本浩之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  National Institute of Infectious Diseases
Single-B-cell dynamics analysis in simian immunodeficiency virus-specific neutralizing antibody inductionPrincipal Investigator
- Principal Investigator
  
  Yamamoto Hiroyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  National Institute of Infectious Diseases
Study of Immune aging
- Principal Investigator
  
  Tachikawa Ai
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  National Institute of Infectious Diseases
Virological and immunological analysis of neutralizing SIV antibody-inducing macaquesPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Hiroyuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  National Institute of Infectious Diseases
Analysis of antibody-dependent cellular virus inhibition(ADCVI) against SIV-infected cellsPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Hiroyuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Virology
- Research Institution
  National Institute of Infectious Diseases
  The University of Tokyo

All 2021 2020 2019 2018 2017 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] A Potent Anti-Simian Immunodeficiency Virus Neutralizing Antibody Induction Associated with a Germ Line Immunoglobulin Gene Polymorphism in Rhesus Macaques2021
- Author(s)
  Matsuoka Saori、Kuwata Takeo、Ishii Hiroshi、Sekizuka Tsuyoshi、Kuroda Makoto、Sano Masato、Okazaki Midori、Yamamoto Hiroyuki、Shimizu Mikiko、Matsushita Shuzo、Seki Yohei、Saito Akatsuki、Sakawaki Hiromi、Hirsch Vanessa M.、Miura Tomoyuki、Akari Hirofumi、Matano Tetsuro
- Journal Title
  
  Journal of Virology
  
  Volume: 95 Issue: 7
- DOI
  10.1128/jvi.02455-20
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02666, KAKENHI-PROJECT-18H02854, KAKENHI-PROJECT-18K06032, KAKENHI-PROJECT-18K07157, KAKENHI-PROJECT-19K06382, KAKENHI-PROJECT-19H03146, KAKENHI-PROJECT-21K05989
[Journal Article] A Novel Immunogen Selectively Eliciting CD8(+) T Cells but Not CD4(+) T Cells Targeting Immunodeficiency Virus Antigens.2020
- Author(s)
  Ishii H, Terahara K, Nomura T, Takeda A, Okazaki M, Yamamoto H, Tokusumi T, Shu T, Matano T.
- Journal Title
  
  Journal of Virology
  
  Volume: 94 Issue: 8
- DOI
  10.1128/jvi.01876-19
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07157, KAKENHI-PROJECT-19K16679, KAKENHI-PROJECT-18H02666
[Journal Article] Therapeutic vaccine-mediated Gag-specific CD8+ T-cell induction under anti-retroviral therapy augments anti-virus efficacy of CD8+ cells in simian immunodeficiency virus-infected macaques2020
- Author(s)
  Nakamura-Hoshi Midori、Takahara Yusuke、Matsuoka Saori、Ishii Hiroshi、Seki Sayuri、Nomura Takushi、Yamamoto Hiroyuki、Sakawaki Hiromi、Miura Tomoyuki、Tokusumi Tsuyoshi、Shu Tsugumine、Matano Tetsuro
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 11394-11394
- DOI
  10.1038/s41598-020-68267-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02666, KAKENHI-PROJECT-19H03146, KAKENHI-PROJECT-18K07157, KAKENHI-PROJECT-18K15175, KAKENHI-PROJECT-19K16679
[Journal Article] CD8+ T cell-based strong selective pressure on multiple simian immunodeficiency virus targets in macaques possessing a protective MHC class I haplotype2019
- Author(s)
  Hau Trang Thi Thu、Nakamura-Hoshi Midori、Kanno Yoshiaki、Nomura Takushi、Nishizawa Masako、Seki Sayuri、Ishii Hiroshi、Kawana-Tachikawa Ai、Hall William W.、Nguyen Thi Lan Anh、Matano Tetsuro、Yamamoto Hiroyuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 512 Issue: 2 Pages: 213-217
- DOI
  10.1016/j.bbrc.2019.03.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07157, KAKENHI-PROJECT-18K15175, KAKENHI-PROJECT-17H02185, KAKENHI-PROJECT-19K16679, KAKENHI-PROJECT-18H02666
[Journal Article] CD8+ Cytotoxic-T-Lymphocyte Breadth Could Facilitate Early Immune Detection of Immunodeficiency Virus-Derived Epitopes with Limited Expression Levels2019
- Author(s)
  Tsukamoto Tetsuo、Yamamoto Hiroyuki、Matano Tetsuro
- Journal Title
  
  mSphere
  
  Volume: 4 Issue: 1
- DOI
  10.1128/msphere.00381-18
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07157, KAKENHI-PROJECT-17H02185, KAKENHI-PROJECT-18H02666
[Journal Article] EVI1 modulates oncogenic role of GPC1 in pancreatic carcinogenesis2017
- Author(s)
  Tanaka Mariko、Ishikawa Shumpei、Ushiku Tetsuo、Morikawa Teppei、Isagawa Takayuki、Yamagishi Makoto、Yamamoto Hiroyuki、Katoh Hiroto、Takeshita Kimiko、Arita Junichi、Sakamoto Yoshihiro、Hasegawa Kiyoshi、Kokudo Norihiro、Fukayama Masashi
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 59 Pages: 99552-99566
- DOI
  10.18632/oncotarget.20601
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09592, KAKENHI-PROJECT-16H05323, KAKENHI-PROJECT-17H02185, KAKENHI-PROJECT-15K06907, KAKENHI-PROJECT-15K19046
[Journal Article] In vivo virulence of MHC-adapted AIDS virus serially-passaged through MHC-mismatched hosts2017
- Author(s)
  Seki Sayuri、Nomura Takushi、Nishizawa Masako、Yamamoto Hiroyuki、Ishii Hiroshi、Matsuoka Saori、Shiino Teiichiro、Sato Hironori、Mizuta Kazuta、Sakawaki Hiromi、Miura Tomoyuki、Naruse Taeko K.、Kimura Akinori、Matano Tetsuro
- Journal Title
  
  PLOS Pathogens
  
  Volume: 13 Issue: 9 Pages: e1006638-e1006638
- DOI
  10.1371/journal.ppat.1006638
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04737, KAKENHI-PROJECT-16H04682, KAKENHI-PROJECT-17H02185, KAKENHI-PROJECT-15K19119
[Journal Article] Identification of SIV Nef CD8(+) T cell epitopes restricted by a MHC class I haplotype associated with lower viral loads in a macaque AIDS model.2014
- Author(s)
  Nomura T, Yamamoto H, Takahashi N, Naruse TK, Kimura A, Matano T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 450 Issue: 2 Pages: 942-947
- DOI
  10.1016/j.bbrc.2014.06.072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590398, KAKENHI-PUBLICLY-25115520, KAKENHI-PROJECT-25860348, KAKENHI-PROJECT-25893294
[Journal Article] Control of SIV replication by vaccine-induced Gag- and Vif-specific CD8+ T cells2014
- Author(s)
  Nami Iwamoto, Naofumi Takahashi, Sayuri Seki, Takushi Nomura, Hiroyuki Yamamoto, Makoto Inoue, Tsugumine Shu, Taeko K. Naruse, Akinori Kimura, and Tetsuro Matano
- Journal Title
  
  J. Virol.
  
  Volume: 88 Issue: 1 Pages: 425-433
- DOI
  10.1128/jvi.02634-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390115, KAKENHI-PROJECT-24590398, KAKENHI-PUBLICLY-25115520, KAKENHI-PROJECT-25860348, KAKENHI-PROJECT-25893294
[Journal Article] Limited impact of passive non-neutralizing antibody immunization in acute SIV infection on viremia control in rhesus macaques2013
- Author(s)
  Taku Nakane, Takushi Nomura, Shoi Shi, Midori Nakamura, Taeko K. Naruse, Akinori Kimura, Tetsuro Matano, and Hiroyuki Yamamoto
- Journal Title
  
  PLoS ONE
  
  Volume: 8 Issue: 9 Pages: e73453-e73453
- DOI
  10.1371/journal.pone.0073453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390115, KAKENHI-PROJECT-24590398, KAKENHI-PUBLICLY-25115520, KAKENHI-PROJECT-25860348, KAKENHI-PROJECT-25893294
[Journal Article] IL-21-producer CD4+ T cell kinetics during primary simian immunodeficiency virus infection2013
- Author(s)
  Shoi Shi, Sayuri Seki, Tetsuro Matano, and Hiroyuki Yamamoto
- Journal Title
  
  Microbes Infect.
  
  Volume: 15 Issue: 10-11 Pages: 697-707
- DOI
  10.1016/j.micinf.2013.06.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390115, KAKENHI-PUBLICLY-25115520, KAKENHI-PROJECT-25860348
[Journal Article] Impact of vaccination on cytotoxic T lymphocyte immunodominance and cooperation against simian immunodeficiency virus replication in rhesus macaques2012
- Author(s)
  Ishii H, Kawada M, Tsukamoto T, Yamamoto H, Matsuoka S, Shiino T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Naruse TK, Kimura A, Takiguchi M, Matano T
- Journal Title
  
  J Virol
  
  Volume: 86 Pages: 738-745
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890040
[Journal Article] Dominant induction of vaccine antigen-specific cytotoxic T lymphocyte responses after simian immuno deficiency virus challenge2011
- Author(s)
  Takahara Y, Matsuoka S, Kuwano T, Tsukamoto T, Yamamoto H, Ishii H, Nakasone T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Sakawaki H, Horiike M, Miura T, Igarashi T, Naruse TK, Kimura A, Matano T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 20;408 Pages: 615-619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890040
[Journal Article] Neutralizing antibodies in SIV contro1 ; co-impact with T cells2010
- Author(s)
  Hiroyuki Yamamoto, Tetsuro Matano
- Journal Title
  
  Vaccine
  
  Volume: 28S2 Pages: 13-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890040
[Journal Article] Neutralizing antibodies in SIV control ; co-impact with T cells2010
- Author(s)
  Yamamoto H, Matano T.
- Journal Title
  
  Vaccine
  
  Volume: 28S2 Pages: 13-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890040
[Presentation] Induction of cross-reactive simian immunodeficiency virus-specific neutralizing antibodies in macaques possessing specific germline B cell receptors2020
- Author(s)
  Yamamoto H, Kuwata T, Matsuoka S, Ishii H, Sekizuka T, Kuroda M, Matsushita S, Seki Y, Sakawaki H, Miura T, Akari H, Matano T
- Organizer
  22nd International Conference on Emerging Infectious Diseases in the Pacific Rim, AIDS Panel Agenda
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07157
[Presentation] Neutralizing antibodies against SIVmac239: T-cell synergism in protection and induction2019
- Author(s)
  Yamamoto H
- Organizer
  第33回日本エイズ学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07157
[Presentation] Nef-specific cytolytic CD4+ T-cell responses in a viremic SIV controller receiving acute-phase neutralizing antibody passive infusion2019
- Author(s)
  Hau TTT, Nomura T, Matano T, Yamamoto H
- Organizer
  第67回日本ウイルス学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07157
[Presentation] Protective and non-protective MHC-I haplotype-associated CD8+ T-cell responses in simian immunodeficiency virus-infected rhesus macaques2018
- Author(s)
  Hau TTT, Nomura T, Seki S, Nakamura-Hoshi M, Ishii H, Matano T, Yamamoto H
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07157
[Presentation] MHC-I haplotype-associated CD8+ T-cell responses in simian immunodeficiency virus-infected rhesus macaques2018
- Author(s)
  Hau TTT, Nomura T, Seki S, Nakamura-Hoshi M, Ishii H, Naruse TK, Kimura A, Matano T, Yamamoto H
- Organizer
  2nd Japan-Taiwan Joint Symposium on HIV/AIDS
- Data Source
  KAKENHI-PROJECT-18K07157
[Presentation] Characterization of neutralizing antibody responses induced in highly neutralization-resistant SIVmac239 infection2018
- Author(s)
  Kanno Y, Nomura T, Hau TTT, Matano T, Yamamoto H
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07157
[Presentation] Anti-SIV neutralizing antibodies: association with immune escape and controlling immune escape2018
- Author(s)
  Yamamoto H
- Organizer
  Immunological intervention of lentivirus infection: control versus escape, Center for AIDS Research Seminar, Kumamoto University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07157
[Presentation] Neutralizing antibodies against highly resistant SIV: protective activity and induction correlates2014
- Author(s)
  Yamamoto H
- Organizer
  WYIS Univ. Kumamoto
- Place of Presentation
  熊本大学
- Invited
- Data Source
  KAKENHI-PROJECT-25860348
[Presentation] センダイウイルスベクターを用いたエイズワクチン2013
- Author(s)
  山本浩之、俣野哲朗
- Organizer
  第17回日本ワクチン学会学術集会
- Place of Presentation
  津
- Invited
- Data Source
  KAKENHI-PROJECT-25860348
[Presentation] Selection of a survival signal-modulating CTL escape mutant precedes SIV neutralizing antibody induction2013
- Author(s)
  Yamamoto H
- Organizer
  12th Awaji International Forum of Infection and Immunity
- Place of Presentation
  淡路島
- Data Source
  KAKENHI-PROJECT-25860348
[Presentation] Post-infection passive immunization of SIVmac239-specific, non-neutralizing antibodies does not control virus replication in vivo2011
- Author(s)
  Nakane T, Matano T, Yamamoto H.
- Organizer
  IUMS 2011(兼第59回日本ウイルス学会学術集会)
- Place of Presentation
  札幌
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22890040
[Presentation] 中和抗体による感染防御機構:サルエイズモデルにおける解析(S12-4)2010
- Author(s)
  山本浩之
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島県徳島県郷土文化会館
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-22890040
[Presentation] 中和抗体による感染防御機構:サルエイズモデルにおける解析2010
- Author(s)
  山本浩之
- Organizer
  第58回日本ウイルス学会学術総会
- Place of Presentation
  徳島
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-22890040
[Presentation] In vivo determinants of SIV neutralizing antibody induction
- Author(s)
  Yamamoto H
- Organizer
  Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2014-09-30 – 2014-10-02
- Data Source
  KAKENHI-PROJECT-25860348

1. Tachikawa Ai (10396880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. NARUSE Taeko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 木村彰方

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 俣野哲朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
5. 砂河孝行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMAMOTO HIROYUKI 山本 浩之

Yamamoto Hiroyuki 山本 浩之

YAMAMOTO Hiroyuki 山本 浩之

Research Projects

Research Products

Co-Researchers

ウイルス易感受性を来す新たな成人発症型IEI（先天性免疫不全疾患）の病態解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

シングルセル画像特徴量への「翻訳」によるウイルス潜伏感染の定義・発見・排除Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Single-B-cell dynamics analysis in simian immunodeficiency virus-specific neutralizing antibody inductionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of Immune aging

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Virological and immunological analysis of neutralizing SIV antibody-inducing macaquesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of antibody-dependent cellular virus inhibition(ADCVI) against SIV-infected cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A Potent Anti-Simian Immunodeficiency Virus Neutralizing Antibody Induction Associated with a Germ Line Immunoglobulin Gene Polymorphism in Rhesus Macaques2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Novel Immunogen Selectively Eliciting CD8(+) T Cells but Not CD4(+) T Cells Targeting Immunodeficiency Virus Antigens.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Therapeutic vaccine-mediated Gag-specific CD8+ T-cell induction under anti-retroviral therapy augments anti-virus efficacy of CD8+ cells in simian immunodeficiency virus-infected macaques2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD8+ T cell-based strong selective pressure on multiple simian immunodeficiency virus targets in macaques possessing a protective MHC class I haplotype2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD8+ Cytotoxic-T-Lymphocyte Breadth Could Facilitate Early Immune Detection of Immunodeficiency Virus-Derived Epitopes with Limited Expression Levels2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EVI1 modulates oncogenic role of GPC1 in pancreatic carcinogenesis2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vivo virulence of MHC-adapted AIDS virus serially-passaged through MHC-mismatched hosts2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of SIV Nef CD8(+) T cell epitopes restricted by a MHC class I haplotype associated with lower viral loads in a macaque AIDS model.2014

Author(s)

Journal Title

YAMAMOTO HIROYUKI 山本浩之

Yamamoto Hiroyuki 山本浩之

YAMAMOTO Hiroyuki 山本浩之