Arimori Takao 有森貴夫

Researcher Number	80582064
Other IDs
Affiliation (Current)	2025: 大阪大学, 蛋白質研究所, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2025: 大阪大学, 蛋白質研究所, 准教授 2019: 大阪大学, 蛋白質研究所, 特任助教(常勤) 2018: 大阪大学, 蛋白質研究所, 助教 2017: 大阪大学, たんぱく質研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Structural biochemistry
Keywords	Principal Investigator 結晶構造解析 / クライオ電子顕微鏡 / 単粒子解析 / 肝細胞増殖因子 / チロシンキナーゼ型受容体 / X線結晶構造解析 / 細胞外マトリックス / 細胞接着 / 抗体工学 / 蛋白質 / SARAHドメインの組み合わせ / Fv-claspのデザイン改変

Investigation of abnormal structures of receptors expressing on cancer cells using cancer-specific antibodiesPrincipal Investigator
- Principal Investigator
  
  有森貴夫
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  The University of Osaka
肝細胞増殖因子HGFによるMet受容体活性化機構の構造学的研究Principal Investigator
- Principal Investigator
  
  有森貴夫
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Osaka University
Elucidation of the laminin recognition mechanism by integrinPrincipal Investigator
- Principal Investigator
  
  Arimori Takao
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Osaka University
新規低分子化抗体フラグメントFv-claspの改良とその構造生物学への応用Principal Investigator
- Principal Investigator
  
  有森貴夫
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019 2017

All Journal Article Presentation

[Journal Article] Locally misfolded HER2 expressed on cancer cells is a promising target for development of cancer-specific antibodies2024
- Author(s)
  Arimori Takao、Mihara Emiko、Suzuki Hiroyuki、Ohishi Tomokazu、Tanaka Tomohiro、Kaneko Mika K.、Takagi Junichi、Kato Yukinari
- Journal Title
  
  Structure
  
  Volume: - Issue: 5 Pages: 536-549.e5
- DOI
  10.1016/j.str.2024.02.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06783, KAKENHI-PROJECT-23K21290
[Journal Article] Engineered fast-dissociating antibody fragments for multiplexed super-resolution microscopy2022
- Author(s)
  Qianli Zhang, Akitoshi Miyamoto, Shin Watanabe, Takao Arimori, Masanori Sakai, Madoka Tomisaki, Tai Kiuchi, Junichi Takagi, Naoki Watanabe
- Journal Title
  
  Cell Reports Methods
  
  Volume: 2 Issue: 10 Pages: 100301-100301
- DOI
  10.1016/j.crmeth.2022.100301
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06168, KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-22H00456, KAKENHI-PROJECT-23K21290
[Journal Article] De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function2022
- Author(s)
  Sugano-Nakamura Nozomi、Matoba Kyoko、Hirose Mika、Bashiruddin Nasir K.、Matsunaga Yukiko、Yamashita Keitaro、Hirata Kunio、Yamamoto Masaki、Arimori Takao、Suga Hiroaki、Takagi Junichi
- Journal Title
  
  Structure
  
  Volume: 30 Issue: 10 Pages: 1411-1423.e4
- DOI
  10.1016/j.str.2022.07.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H05618, KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-23K21290
[Journal Article] Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins2021
- Author(s)
  Mihara E, Watanabe S, Bashiruddin N, Nakamura N, Matoba K, Maini R, Yin Y, Sakai K, Arimori T, Matsumoto K, Suga H, and Takagi J.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1543-1543
- DOI
  10.1038/s41467-021-21875-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-18H02389, KAKENHI-PROJECT-20H05618, KAKENHI-PROJECT-19H03499, KAKENHI-PROJECT-20K06553, KAKENHI-PROJECT-21K18250, KAKENHI-PROJECT-20K20581
[Journal Article] A feasibility study of inverse contrast-matching small-angle neutron scattering method combined with size exclusion chromatography using antibody interactions as model systems2021
- Author(s)
  Sato Nobuhiro、Yogo Rina、Yanaka Saeko、Martel Anne、Porcar Lionel、Morishima Ken、Inoue Rintaro、Tominaga Taiki、Arimori Takao、Takagi Junichi、Sugiyama Masaaki、Kato Koichi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 0 Issue: 6 Pages: 1-8
- DOI
  10.1093/jb/mvab012
- NAID
  40022687772
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15981, KAKENHI-PROJECT-19KK0071, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-19H01017, KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-18H02389, KAKENHI-PROJECT-19J15602, KAKENHI-PROJECT-17K07816, KAKENHI-PROJECT-19K16088, KAKENHI-PROJECT-18H05229, KAKENHI-PROJECT-20K20581
[Journal Article] High affinity modified ACE2 receptors protect from SARS-CoV-2 infection.2020
- Author(s)
  Higuchi Y, Suzuki T, Arimori T, Ikemura N, Kirita Y, Ohgitani E, Mazda O, Motooka D, Nakamura S, Matsuura Y, Matoba S, Okamoto T, Takagi J, and Hoshino A.
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2020.09.16.299891
- Open Access
- Data Source
  KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-18H02389, KAKENHI-PROJECT-20K20581
[Journal Article] Site-specific epitope insertion into recombinant proteins using the MAP tag system.2020
- Author(s)
  Wakasa A, Kaneko MK, Kato Y, Takagi J, and Arimori T.
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 168 Issue: 4 Pages: 375-384
- DOI
  10.1093/jb/mvaa054
- NAID
  40022393375
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-18H02389, KAKENHI-PROJECT-20K20581
[Journal Article] X-ray Structure Analysis of Human Oxidized Nucleotide Hydrolase MTH1 using Crystals Obtained under Microgravity2019
- Author(s)
  Nakamura T, Hirata K, Fujimiya K, Chirifu M, Arimori T, Tamada T, Ikemizu S, Yamagata Y
- Journal Title
  
  International journal of microgravity science and application
  
  Volume: 36 Issue: 1 Pages: 360103
- DOI
  10.15011//jasma.36.360103
- NAID
  130007769928
- ISSN
  2188-9783
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06600, KAKENHI-PROJECT-16K07276, KAKENHI-PROJECT-18H02389
[Journal Article] Crystal structure of a mammalian Wnt-frizzled complex.2019
- Author(s)
  Hirai H, Matoba K, Mihara E, Arimori T, Takagi J
- Journal Title
  
  Nature structural & molecular biology
  
  Volume: 26(5) Issue: 5 Pages: 372-379
- DOI
  10.1038/s41594-019-0216-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-18H02389, KAKENHI-PROJECT-18K19298
[Journal Article] Fv-clasp: An Artificially Designed Small Antibody Fragment with Improved Production Compatibility, Stability, and Crystallizability2017
- Author(s)
  Arimori Takao、Kitago Yu、Umitsu Masataka、Fujii Yuki、Asaki Ryoko、Tamura-Kawakami Keiko、Takagi Junichi
- Journal Title
  
  Structure
  
  Volume: 25 Issue: 10 Pages: 1611-1622.e4
- DOI
  10.1016/j.str.2017.08.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H06839, KAKENHI-PROJECT-17H01420
[Presentation] がん特異的抗HER2抗体の構造から見えてきたがん抗原探索の新たな戦略2023
- Author(s)
  有森　貴夫、加藤　幸成
- Organizer
  第32回日本がん転移学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21290
[Presentation] HER2の局所的なミスフォールド部位を認識する新規がん特異的抗体の開発2023
- Author(s)
  有森貴夫, 三原恵美子, 金子美華, 高木淳一, 加藤幸成
- Organizer
  第96回　日本生化学会年会
- Data Source
  KAKENHI-PROJECT-23K21290
[Presentation] がん特異的抗体MMG49の抗原認識機構の解明に向けたX線結晶構造解析2023
- Author(s)
  佐々木　優奈、保仙　直毅、高木　淳一、有森　貴夫
- Organizer
  令和5年(2023年)度　日本結晶学会年会
- Data Source
  KAKENHI-PROJECT-23K21290
[Presentation] がん特異的抗HER2抗体の正常細胞/がん細胞識別機構2023
- Author(s)
  有森貴夫，三原恵美子，鈴木裕之，大石智一，田中智大，金子美華，高木淳一，加藤幸成
- Organizer
  第2回　日本抗体学会
- Data Source
  KAKENHI-PROJECT-23K21290
[Presentation] Crystal structure of a cancer-specific anti-HER2 antibody2023
- Author(s)
  T. Arimori, J. Takagi, Y. Kato
- Organizer
  XXI IUCr Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21290
[Presentation] Engineered antibody fragment "Fv-clasp" for various research applications.2023
- Author(s)
  Takao Arimori
- Organizer
  IPR X RIKEN BDR Symposium 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21290
[Presentation] Mirabody を用いた上皮成長因子受容体 (EGFR) の人工作動薬創成2023
- Author(s)
  新田あずさ、水谷文哉、三原恵美子、有森貴夫、高木淳一
- Organizer
  第23回　日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K21290
[Presentation] Fcヒンジ切断酵素IdeSを利用したハイスループット組換え蛋白質生産系の構築2023
- Author(s)
  有森貴夫，高木淳一
- Organizer
  第23回　日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K21290
[Presentation] 受容体作動薬創成技術、Mirabody法の上皮成長因子受容体(EGFR)への応用2023
- Author(s)
  新田あずさ, 水谷文哉, 三原恵美子, 有森貴夫, 高木淳一
- Organizer
  第96回　日本生化学会年会
- Data Source
  KAKENHI-PROJECT-23K21290
[Presentation] 小型抗体フォーマット「Fv-clasp」の開発とその応用2023
- Author(s)
  有森　貴夫
- Organizer
  第74回日本電気泳動学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21290
[Presentation] 高難度組換え蛋白質生産と構造解析の支援・高度化・今後の展望2022
- Author(s)
  有森貴夫
- Organizer
  2021年度 AMED BINDSセミナー
- Data Source
  KAKENHI-PROJECT-23K21290
[Presentation] タンパク質工学を駆使したバイオ医薬品創製への挑戦2021
- Author(s)
  有森貴夫
- Organizer
  キャタリストユニット講演会 Top Runners in TRS
- Invited
- Data Source
  KAKENHI-PROJECT-23K21290
[Presentation] 血液凝固第XII因子の活性化抑制における糖鎖修飾の役割2020
- Author(s)
  中村澄香、小川光貴、竹内英之、岡島徹也、有森貴夫、高木淳一、相川京子
- Organizer
  第93回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H02389
[Presentation] Stable antibody fragment format 'Fv-clasp': Application to challenging structural studies2020
- Author(s)
  Takao Arimori, Naoyuki Miyazaki, and Junichi Takagi
- Organizer
  第20回　日本蛋白質科学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02389
[Presentation] タンパク質結晶化に応用可能な新規小型抗体フォーマットFv-claspの開発2020
- Author(s)
  有森　貴夫
- Organizer
  令和2年日本結晶学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02389
[Presentation] 抗うつ薬フルボキサミン-抗体複合体の小型抗体フォーマットFv-claspを用いた結晶作製2020
- Author(s)
  笹尾亜子、黒澤凜、山口佳宏、有森貴夫、大津由紀、堤博志、古川翔太、高木淳一、西谷陽子
- Organizer
  第104回　日本法医学会学術全国集会
- Data Source
  KAKENHI-PROJECT-18H02389
[Presentation] HGF-Metシグナル伝達経路におけるHGF活性変換機構の構造基盤2019
- Author(s)
  有森　貴夫
- Organizer
  蛋白研セミナー：がん研究の新機軸
- Invited
- Data Source
  KAKENHI-PROJECT-18H02389
[Presentation] 抗MAPタグ抗体の結晶構造とMAPタグシステムの新たな応用法2019
- Author(s)
  有森　貴夫，若狭　彩美，金子　美華，加藤　幸成，高木　淳一
- Organizer
  第19回　日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18H02389
[Presentation] Development of an artificially designed antibody fragment “Fv-clasp”2019
- Author(s)
  Takao Arimori
- Organizer
  分子研研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02389
[Presentation] Crystal structure of human Wnt3 in complex with mouse Frizzled 82019
- Author(s)
  平井秀憲、的場京子、三原恵美子、有森貴夫、高木淳一
- Organizer
  第19回　日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18H02389
[Presentation] 血液凝固第XII因子の活性化におけるEGF様ドメインのO-結合型糖鎖修飾の役割2019
- Author(s)
  中村澄香、小川光貴、竹内英之、岡島徹也、有森貴夫、高木淳一、相川京子
- Organizer
  第38回　日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-18H02389
[Presentation] Crystallization and structure determination of laminin-binding integrin α6β1 aided by the use of Fv-clasp technology2017
- Author(s)
  Takao Arimori, Junichi Takagi
- Organizer
  第55回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17H06839

1. SUGA Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 高木淳一

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
3. 谷中冴子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 木内泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 大石智一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Arimori Takao 有森 貴夫

Research Projects

Research Products

Co-Researchers

Investigation of abnormal structures of receptors expressing on cancer cells using cancer-specific antibodiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肝細胞増殖因子HGFによるMet受容体活性化機構の構造学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the laminin recognition mechanism by integrinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規低分子化抗体フラグメントFv-claspの改良とその構造生物学への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Locally misfolded HER2 expressed on cancer cells is a promising target for development of cancer-specific antibodies2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Engineered fast-dissociating antibody fragments for multiplexed super-resolution microscopy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A feasibility study of inverse contrast-matching small-angle neutron scattering method combined with size exclusion chromatography using antibody interactions as model systems2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] High affinity modified ACE2 receptors protect from SARS-CoV-2 infection.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Site-specific epitope insertion into recombinant proteins using the MAP tag system.2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] X-ray Structure Analysis of Human Oxidized Nucleotide Hydrolase MTH1 using Crystals Obtained under Microgravity2019

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Crystal structure of a mammalian Wnt-frizzled complex.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fv-clasp: An Artificially Designed Small Antibody Fragment with Improved Production Compatibility, Stability, and Crystallizability2017

Author(s)

Arimori Takao 有森貴夫

[Presentation] タンパク質工学を駆使したバイオ医薬品創製への挑戦2021