GEN YASUYUKI 玄泰行

Researcher Number	80596156
Other IDs
Affiliation (based on the past Project Information) *help	2021: 東京医科歯科大学, 難治疾患研究所, 非常勤講師 2016 – 2020: 東京医科歯科大学, 難治疾患研究所, 助教 2012 – 2015: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Human genetics / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Complex systems
Keywords	Principal Investigator miRNA / 食道扁平上皮癌 / SOX2 / WNT-β-catenin / BRD4-NUT / WNT/β-catenin / super-enhancer / スーパーエンハンサー / NUT正中線癌 / 核酸抗癌薬 … More / MYC / CBP / BRD4 / miR-766-5p / PTEN / esophageal cancer / mTORC1 / ｍTORC1 / mTOR / AKT / 遺伝子増幅 / 食道癌 … More Except Principal Investigator 核酸医薬 / マイクロRNA / BETファミリ－蛋白 / DNA損傷修復 / BETファミリーBRD4 / 抗がん核酸製剤 / スーパーエンハンサー / miR-3140-3p / miR-1293 / DNA修復経路 / BRD4 / BETファミリー蛋白 / 抗癌性核酸医薬 / 癌 / ゲノム / 核酸創薬 / 既存薬再配置 / がん / オートファジー / システム生物学 / 浸潤・転移 / がん特性 / 核酸抗がん薬 / がん抑制型マイクロRNA / がん悪性特性 / DR / がん代謝異常 / オミクス / がん細胞文脈 / バイオマーカー / 分子標的治療 / DDS / オミクス解析 / 上皮間葉転換（EMT) / 細胞文脈 Less

Oligonucleotide therapeutics using a novel tumor-suppressive microRNA targeting MYC pathwayPrincipal Investigator
- Principal Investigator
  
  Yasuyuki Gen
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical and Dental University
Development of therapeutic miRNAs targeting BET family protein BRD4 for cancer
- Principal Investigator
  
  Inazawa Johji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical and Dental University
Examination of the mechanisms by which SOX2 promotes cell proliferation in esophageal cancerPrincipal Investigator
- Principal Investigator
  
  GEN Yasuyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human genetics
- Research Institution
  Tokyo Medical and Dental University
  Kyoto Prefectural University of Medicine
Establishment of novel concept for cancer diagnostics and therapeutics based on the systematic comprehension of cellular context in cancer
- Principal Investigator
  
  Inazawa Johji
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tokyo Medical and Dental University
SOX2, an amplification target of 3q26.3, promote tumor proliferation via AKT signaling in esophageal cancerPrincipal Investigator
- Principal Investigator
  
  GEN YASUYUKI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human genetics
- Research Institution
  Kyoto Prefectural University of Medicine

All 2021 2020 2019 2018 2017 2016 2013 2012 Other

All Journal Article Presentation Patent Other

[Journal Article] Concurrent targeting of MAP3K3 and BRD4 by miR-3140-3p overcomes acquired resistance to BET inhibitors in neuroblastoma cells.2021
- Author(s)
  Liu C, Gen Y, Tanimoto K, Muramatsu T, Inoue J, Inazawa J.
- Journal Title
  
  Mol Ther Nucleic Acids.
  
  Volume: 25 Pages: 83-92
- DOI
  10.1016/j.omtn.2021.05.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07709, KAKENHI-PROJECT-21H02781
[Journal Article] SOX2 enhances cell survival and induces resistance to apoptosis under serum starvation conditions through the AKT/GSK-3β signaling pathway in esophageal squamous cell carcinoma.2021
- Author(s)
  Terasaki K, Gen Y, Iwai N, Soda T, Kitaichi T, Dohi O, Taketani H, Seko Y, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Konishi H, Naito Y, Itoh Y, Yasui K.
- Journal Title
  
  Oncol Lett.
  
  Volume: 21 Pages: 269-269
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07709
[Journal Article] miR-766-5p Targets Super-Enhancers by Downregulating CBP and BRD4.2021
- Author(s)
  Gen Y, Muramatsu T, Inoue J, Inazawa J.
- Journal Title
  
  Cancer Res.
  
  Volume: 81 Issue: 20 Pages: 5190-5201
- DOI
  10.1158/0008-5472.can-21-0649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07709, KAKENHI-PROJECT-21H02781
[Journal Article] miR-1293, a Candidate for miRNA-Based Cancer Therapeutics, Simultaneously Targets BRD4 and the DNA Repair Pathway.2020
- Author(s)
  Takagawa Y, Gen Y, Muramatsu T, Tanimoto K, Inoue J, Harada H, Inazawa J.
- Journal Title
  
  Mol Ther.
  
  Volume: 28 Pages: 1494-1505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07709
[Journal Article] miR-1293, a Candidate for miRNA-Based Cancer Therapeutics, Simultaneously Targets BRD4 and the DNA Repair Pathway2020
- Author(s)
  Takagawa Yuki、Gen Yasuyuki、Muramatsu Tomoki、Tanimoto Kousuke、Inoue Jun、Harada Hiroyuki、Inazawa Johji
- Journal Title
  
  Molecular Therapy
  
  Volume: 28 Issue: 6 Pages: 1494-1505
- DOI
  10.1016/j.ymthe.2020.04.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02688, KAKENHI-PROJECT-18K06954
[Journal Article] miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein2018
- Author(s)
  Tonouchi Erina、Gen Yasuyuki、Muramatsu Tomoki、Hiramoto Hidekazu、Tanimoto Kousuke、Inoue Jun、Inazawa Johji
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 4482-4482
- DOI
  10.1038/s41598-018-22767-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K14630, KAKENHI-PROJECT-15K19040, KAKENHI-PLANNED-15H05908, KAKENHI-PROJECT-18H02688
[Journal Article] Loss of PAR-3 protein expression is associated with invasion, lymph node metastasis, and poor survival in esophageal squamous cell carcinoma.2017
- Author(s)
  Kitaichi T, Yasui K, Gen Y, Dohi O, Iwai N, Tomie A, Yamada N, Terasaki K, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Sumida Y, Mitsuyoshi H, Naito Y, Zen Y, Itoh Y.
- Journal Title
  
  Hum Pathol
  
  Volume: 62 Pages: 134-140
- DOI
  10.1016/j.humpath.2017.01.009
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09017, KAKENHI-PROJECT-15K19040
[Journal Article] p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.2016
- Author(s)
  Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M.
- Journal Title
  
  Cancer Cell
  
  Volume: 29 Pages: 935-948
- DOI
  10.1016/j.canlet.2017.04.002
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06547, KAKENHI-PROJECT-15K09017, KAKENHI-PROJECT-16K10512, KAKENHI-PROJECT-15K19040
[Journal Article] SOX2 promotes tumor growth of esophageal squamous cell carcinoma via the AKT/ mTORC1 signaling pathway.2013
- Author(s)
  Gen Y, Yasui K, Nishikawa T, Yoshikawa T.
- Journal Title
  
  Cancer Sci
  
  Volume: 104 Issue: 7 Pages: 810-816
- DOI
  10.1111/cas.12155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590470, KAKENHI-PROJECT-24790339
[Patent] 医薬組成物2020
- Inventor(s)
  稲澤　譲治、玄　泰之、井上　純、村松　智輝、高川　祐希
- Industrial Property Rights Holder
  国立大学法人東京医科歯科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02688
[Patent] 医薬組成物2019
- Inventor(s)
  稲澤譲治、玄泰之、井上純、村松智輝、高川祐希
- Industrial Property Rights Holder
  国立大学法人東京医科歯科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-233250
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18H02688
[Patent] マイクロRNA及びその誘導体を有効成分とする医薬組成物2019
- Inventor(s)
  稲澤譲治、玄泰行、井上純、村松智輝、高川祐希
- Industrial Property Rights Holder
  国立大学法人　東京医科歯科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-233250
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K07709
[Patent] 医薬組成物2019
- Inventor(s)
  稲澤譲治、玄泰之、井上純、村松智輝、高川祐希
- Industrial Property Rights Holder
  国立大学法人東京医科歯科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-233250
- Filing Date
  2019
- Data Source
  KAKENHI-PLANNED-15H05908
[Patent] マイクロＲＮＡ及びその誘導体を有効成分とする医薬組成物2018
- Inventor(s)
  稲澤譲治、玄泰行、村松智輝、外内えり奈
- Industrial Property Rights Holder
  国立大学法人東京医科歯科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PLANNED-15H05908
[Patent] マイクロＲＮＡ及びその誘導体を有効成分とする医薬組成物2018
- Inventor(s)
  稲澤譲治、玄泰行、村松智輝、外内えり奈
- Industrial Property Rights Holder
  国立大学法人東京医科歯科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PLANNED-15H05908
[Patent] マイクロＲＮＡ及びその誘導体を有効成分とする医薬組成物2018
- Inventor(s)
  稲澤譲治、玄泰行、村松智輝、外内えり奈
- Industrial Property Rights Holder
  国立大学法人東京医科歯科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02688
[Patent] マイクロＲＮＡ及びその誘導体を有効成分とする医薬組成物2018
- Inventor(s)
  稲澤譲治、玄泰行、村松智輝、外内えり奈
- Industrial Property Rights Holder
  国立大学法人東京医科歯科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-18H02688
[Patent] マイクロRNA及びその誘導体を有効成分とするがん治療剤2017
- Inventor(s)
  稲澤譲治、玄泰行、村松智輝、外内えり奈
- Industrial Property Rights Holder
  稲澤譲治、玄泰行、村松智輝、外内えり奈
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-229046
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15K19040
[Patent] マイクロRNA及びその誘導体を有効成分とするがん治療剤2017
- Inventor(s)
  稲澤譲治、玄泰行、村松智輝、外内えり奈
- Industrial Property Rights Holder
  国立大学法人東京医科歯科大学、株式会社ビー・エム・エル
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-229046
- Filing Date
  2017
- Data Source
  KAKENHI-PLANNED-15H05908
[Presentation] Concurrent targeting of MAP3K3 and BRD4 by miR 3140 3p overcomes acquired resistance to BET inhibitors in neuroblastoma cells2021
- Author(s)
  劉暢、玄泰行、稲澤譲治
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07709
[Presentation] スーパーエンハンサーを標的としたmiRNA核酸抗癌薬の開発.2021
- Author(s)
  玄泰行、村松智輝、井上純、稲澤譲治
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07709
[Presentation] Targeting super-enhancers by downregulating CBP and BRD4 using miR-766-5p-based cancer therapeutics2021
- Author(s)
  玄泰行、稲澤譲治
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07709
[Presentation] miR-3140はBRD4-MYCN 経路を標的とし、神経芽腫細胞の増殖を抑制する2020
- Author(s)
  劉暢、玄泰行、稲澤譲治
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02688
[Presentation] MYC経路を標的とする新規腫瘍抑制型miRNAの同定2020
- Author(s)
  玄泰行、稲澤譲治
- Organizer
  第24回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-19K07709
[Presentation] MYC経路を標的とする新規腫瘍抑制型miRNAを用いた核酸抗癌薬の可能性2020
- Author(s)
  玄泰行、稲澤譲治
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07709
[Presentation] MYC 経路を標的とする新規腫瘍抑制型 miRNA の同定2020
- Author(s)
  玄泰行、稲澤譲治
- Organizer
  第24回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-18H02688
[Presentation] miR-3140はBRD4-MYCN経路を標的とし、神経芽腫細胞の増殖を抑制する2020
- Author(s)
  劉暢、玄泰行、稲澤譲治
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07709
[Presentation] MYC 経路を標的とする新規腫瘍抑制型 miRNA を用いた核酸抗癌薬の可能性2020
- Author(s)
  玄泰行、稲澤譲治
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02688
[Presentation] miR-3140 は BRD4-MYCN 経路を標的とし、神経芽腫細胞の増殖を抑制する2019
- Author(s)
  劉暢、玄泰行、稲澤譲治
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-15H05908
[Presentation] The exploration of novel tumor suppressive miRNAs using function-based miRNA screening2019
- Author(s)
  Gen Y, Inoue J, Inazawa J.
- Organizer
  The 3rd International Symposium of International Society of Precision Cancer Medicine 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05908
[Presentation] Exploring novel tumor suppressive microRNAs in OSCC2019
- Author(s)
  Takagawa Y, Gen Y, Muramatsu T, Harada H, Inazawa J.
- Organizer
  The 3rd International Symposium of International Society of Precision Cancer Medicine 2019
- Data Source
  KAKENHI-PROJECT-18H02688
[Presentation] Function-based microRNA library screening identified novel tumor suppressive microRNAs targeting BRD42019
- Author(s)
  Yuki Takagawa, Yasuyuki Gen, Tomoki Muramatsu, Hiroyuki Harada, Johji Inazawa
- Organizer
  第78回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07709
[Presentation] Oligonucleotide therapeutics using a novel tumor-suppressive microRNA targeting MYC pathway2019
- Author(s)
  Yasuyuki Gen, Tomoki Muramatsu, Jun Inoue, Johji Inazawa
- Organizer
  第78回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07709
[Presentation] 核酸抗癌薬を目指した新規腫瘍抑制型 miRNA の探索2019
- Author(s)
  玄泰行、村松智輝、井上純、稲澤譲治
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PLANNED-15H05908
[Presentation] 機能的 miRNA ライブラリースクリーニングによる、BRD4 を標的とする新規癌抑制型 miRNA の同定2019
- Author(s)
  高川祐希、玄泰行、村松智輝、原田浩之、稲澤譲治
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02688
[Presentation] 機能的 miRNA ライブラリースクリーニングによる、BRD4 を標的とする新規癌抑制型 miRNA の同定2019
- Author(s)
  高川祐希、玄泰行、村松智輝、原田浩之、稲澤譲治
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-15H05908
[Presentation] miR-3140 は BRD4-MYCN 経路を標的とし、神経芽腫細胞の増殖を抑制する2019
- Author(s)
  劉暢、玄泰行、稲澤譲治
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02688
[Presentation] 新規癌抑制型 miRNA による MYC 標的核酸抗癌治療の可能性2019
- Author(s)
  玄泰行、村松智輝、井上純、稲澤譲治
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02688
[Presentation] The exploration of novel tumor suppressive miRNAs using function-based miRNA screening2019
- Author(s)
  Gen Y, Inoue J, Inazawa J
- Organizer
  The 3rd International Symposium of International Society of Precision Cancer Medicine 2019
- Data Source
  KAKENHI-PROJECT-18H02688
[Presentation] 核酸抗癌薬を目指した新規腫瘍抑制型miRNAの探索2019
- Author(s)
  玄泰行、村松智輝、井上純、稲澤譲治
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07709
[Presentation] Exploring novel tumor suppressive microRNAs in OSCC.2019
- Author(s)
  Takagawa Y, Gen Y, Muramatsu T, Harada H, Inazawa J
- Organizer
  The 3rd International Symposium of International Society of Precision Cancer Medicine 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05908
[Presentation] 核酸抗癌薬を目指した新規腫瘍抑制型 miRNA の探索2019
- Author(s)
  玄泰行、村松智輝、井上純、稲澤譲治
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02688
[Presentation] 新規癌抑制型 miRNA による MYC 標的核酸抗癌治療の可能性2019
- Author(s)
  玄泰行、村松智輝、井上純、稲澤譲治
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-15H05908
[Presentation] 機能的miRNAスクリーニングを用いた、p53不活性型癌に細胞死を誘導するmiRNAの探索2018
- Author(s)
  玄泰行、井上純、稲澤譲治
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-15H05908
[Presentation] 口腔扁平上皮癌における新規のがん抑制型マイクロRNAの探索2018
- Author(s)
  髙川祐希、玄泰行、村松智輝、原田浩之、稲澤譲治
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-15H05908
[Presentation] 口腔扁平上皮癌における新規のがん抑制型マイクロRNAの探索2018
- Author(s)
  髙川祐希、玄泰行、村松智輝、原田浩之、稲澤譲治
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02688
[Presentation] 機能的miRNAスクリーニングを用いた、p53不活性型癌に細胞死を誘導するmiRNAの探索2018
- Author(s)
  玄泰行、井上純、稲澤譲治
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02688
[Presentation] miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein2018
- Author(s)
  Muramatsu T, Tonouchi E, Gen Y, Hiramoto H, Tanimoto K, Inoue J, Inazawa J
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05908
[Presentation] miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein2018
- Author(s)
  Muramatsu T, Tonouchi E, Gen Y, Hiramoto H, Tanimoto K, Inoue J, Inazawa J
- Organizer
  AACR Annual Meeting 2018
- Data Source
  KAKENHI-PROJECT-18H02688
[Presentation] 機能的miRNAスクリーニングを用いたp53不活性型癌に細胞死を誘導するmiRNAの探索2017
- Author(s)
  玄泰行、井上純、稲澤譲治
- Organizer
  日本人類遺伝学会第62回大会
- Data Source
  KAKENHI-PROJECT-15K19040
[Presentation] 機能的miRNA ライブラリースクリーニングを用いた、BET family 遺伝子を制御するがん抑制型miRNA の同定2017
- Author(s)
  外内えり奈、村松智輝、玄泰行、平本秀一、稲澤譲治.
- Organizer
  第76 回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-15H05908
[Presentation] 機能的miRNA スクリーニングを用いた、p53 不活性型癌に細胞死を誘導する miRNA の探索2017
- Author(s)
  玄泰行、井上純、稲澤譲治
- Organizer
  第76 回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-15H05908
[Presentation] The exploration of miRNAs that induce cell death in p53 inactive cancer cells using functional-miRNA screening2017
- Author(s)
  Yasuyuki Gen, Jun Inoue1, Johji Inazawa,
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K19040
[Presentation] SOX2 promotes tumor growth via activation of PI3K/AKT/mTORC1 pathway in esophageal squamous cell carcinoma2013
- Author(s)
  玄　泰行
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24790339
[Presentation] SOX2 promotes tumor growth via activation of PI3K/Akt/mTOR pathway in esophageal squamous cell carcinoma2012
- Author(s)
  玄　泰行
- Organizer
  日本癌学会
- Place of Presentation
  札幌教育文化会館
- Data Source
  KAKENHI-PROJECT-24790339
[Presentation] SOX2 regulates PTEN via miR-19a in esophageal squamous cell carcinoma
- Author(s)
  玄　泰行
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24790339
[Presentation] 食道扁平上皮癌の増幅遺伝子SOX2はPTEN/AKT/mTORC1経路を介して腫瘍増殖を促進する
- Author(s)
  玄　泰行
- Organizer
  第100回日本消化器病学会総会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2014-04-23 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24790339
[Presentation] SOX2 promotes tumor growth via activation of the PI3K/Akt/mTORC1 signaling pathway in esophageal squamous cell carcionoma
- Author(s)
  Yasuyuki Gen
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego Convention center
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-24790339
[]

1. Inazawa Johji (30193551)

# of Collaborated Projects: 2 results

# of Collaborated Products: 25 results
2. 井上純 (50568326)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
3. 村松智輝 (90732553)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
4. 谷本幸介 (60611613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 安居幸一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 楳村敦詩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

GEN YASUYUKI 玄 泰行

Research Projects

Research Products

Co-Researchers

Oligonucleotide therapeutics using a novel tumor-suppressive microRNA targeting MYC pathwayPrincipal Investigator

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Development of therapeutic miRNAs targeting BET family protein BRD4 for cancer

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Examination of the mechanisms by which SOX2 promotes cell proliferation in esophageal cancerPrincipal Investigator

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Establishment of novel concept for cancer diagnostics and therapeutics based on the systematic comprehension of cellular context in cancer

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SOX2, an amplification target of 3q26.3, promote tumor proliferation via AKT signaling in esophageal cancerPrincipal Investigator

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[Journal Article] Concurrent targeting of MAP3K3 and BRD4 by miR-3140-3p overcomes acquired resistance to BET inhibitors in neuroblastoma cells.2021

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[Journal Article] SOX2 enhances cell survival and induces resistance to apoptosis under serum starvation conditions through the AKT/GSK-3β signaling pathway in esophageal squamous cell carcinoma.2021

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[Journal Article] miR-766-5p Targets Super-Enhancers by Downregulating CBP and BRD4.2021

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[Journal Article] miR-1293, a Candidate for miRNA-Based Cancer Therapeutics, Simultaneously Targets BRD4 and the DNA Repair Pathway.2020

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[Journal Article] miR-1293, a Candidate for miRNA-Based Cancer Therapeutics, Simultaneously Targets BRD4 and the DNA Repair Pathway2020

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[Journal Article] miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein2018

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[Journal Article] Loss of PAR-3 protein expression is associated with invasion, lymph node metastasis, and poor survival in esophageal squamous cell carcinoma.2017

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[Journal Article] p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.2016

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[Journal Article] SOX2 promotes tumor growth of esophageal squamous cell carcinoma via the AKT/ mTORC1 signaling pathway.2013

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[Patent] 医薬組成物2020

Inventor(s)

Industrial Property Rights Holder

GEN YASUYUKI 玄泰行