Miyazaki Daigo 宮崎大吾

… Alternative Names

宮崎大吾ミヤザキダイゴ

MIYAZAKI Daigo 宮崎大吾

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Researcher Number	80596370
Affiliation (Current)	2025: 信州大学, 医学部, 特任講師
Affiliation (based on the past Project Information) *help	2022 – 2023: 信州大学, 医学部附属病院, 講師(特定雇用) 2015 – 2020: 信州大学, 医学部附属病院, 講師(特定雇用) 2018: 信州大学, 医学部附属病院, 講師 2015: 信州大学, 医学部附属病院, 講師
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related Except Principal Investigator Pediatrics / Basic Section 47040:Pharmacology-related / Applied pharmacology
Keywords	Principal Investigator 重症化機序 / イン・フレーム型変異 / ゲノム編集モデルマウス / 筋ジストロフィー / ゲノム編集 / モデルマウス / BMD / ジストロフィン / iPS細胞 / 心筋細胞 … More / デュシェンヌ型筋ジストロフィー / IGF2 / 心不全 / Duchenne型筋ジストロフィー … More Except Principal Investigator 筋ジストロフィー / オステオポンチン / MMP-9 / DMD遺伝子 / エクソンスキップ治療 / iPS細胞 / エクソン・スキップ治療 / ジストロフィン / アンチセンス核酸 / Duchenne型筋ジストロフィー / ゲノム編集 / アンチセンス薬 / ベッカー型筋ジストロフィー / デュシェンヌ型筋ジストロフィー / Osteopontin / Fibrosis / dystrophin / MIP-2 / MCP-1 / 骨格筋細胞 / 網羅的遺伝子発現解析 / 心筋細胞 / アンチセンスオリゴヌクレオチド Less

重症度の異なるゲノム編集マウスを用いた筋ジストロフィー重症化機序に関する研究Principal Investigator
- Principal Investigator
  
  宮崎大吾
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Shinshu University
Research on pathogenesis and development of therapies for cardiac failure using dystrophin-deficient-cardiomyocytes derived from DMD patientsPrincipal Investigator
- Principal Investigator
  
  Miyazaki Daigo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Shinshu University
Development of DMD exon 3-9 skipping therapy using iPSc
- Principal Investigator
  
  Nakamura Akinori
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Shinshu University
Development of molecular targeted therapeutics for Duchenne muscular dystrophy
- Principal Investigator
  
  Shiba Naoko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University
Exon 45 skipping theraphy using iPS cells deleted exons 46-55 in the DMD gene
- Principal Investigator
  
  Akinori Nakamura
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Shinshu University
Development of the therapy for Duchenne muscular dystrophy targeting MMP-9
- Principal Investigator
  
  SHIBA Naoko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes.2019
- Author(s)
  Sato M, Shiba N, Miyazaki D, Shiba Y, Echigoya Y, Yokota T, Takizawa H, Aoki Y, Takeda S, Nakamura A.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 520 Issue: 1 Pages: 179-185
- DOI
  10.1016/j.bbrc.2019.09.095
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02577, KAKENHI-PROJECT-18H02887, KAKENHI-PROJECT-18K15026, KAKENHI-PROJECT-18K14595
[Journal Article] DMD患者iPS細胞由来の心筋細胞における分化・再生関連遺伝子の発現低下と心筋障害の発症機序に関する研究2018
- Author(s)
  宮崎大吾, 佐藤充人, 柴直子, 柴祐司, 青木吉嗣, 武田伸一, 中村昭則
- Journal Title
  
  日本筋学会学術集会プログラム・抄録集
  
  Volume: 4 Pages: 158-158
- Data Source
  KAKENHI-PROJECT-16K19636
[Journal Article] Comparison of the phenotypes of patients harboring in-frame deletions starting at exon 45 in the Duchenne muscular dystrophy gene indicates potential for the development of exon skipping therapy2017
- Author(s)
  Akinori Nakamura, Naoko Shiba, Daigo Miyazaki, Hitomi Nishizawa, Yuji Inaba, Noboru Fueki, Rika Maruyama, Yusuke Echigoya & Toshifumi Yokota
- Journal Title
  
  Journal of human genetics
  
  Volume: 62 Issue: 4 Pages: 459-463
- DOI
  10.1038/jhg.2016.152
- NAID
  40021158222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19636
[Journal Article] Differential roles of MMP-9 in early and late stages of dystrophic muscles in a mouse model of Duchenne muscular dystrophy2015
- Author(s)
  Naoko Shiba, Daigo Miyazaki, Takahiro Yoshizawa, Kazuhiro Fukushima, Yuji Shiba, Yuji Inaba, Michihiro Imamura, Shin'ichi Takeda, Kenichi Koike, Akinori Nakamura
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: 1852 Issue: 10 Pages: 2170-2182
- DOI
  10.1016/j.bbadis.2015.07.008
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860792, KAKENHI-PROJECT-26293182
[Presentation] 重症度の異なるエクソン欠失を持つベッカー型筋ジストロフィーモデルマウスの表現型および病理学的比較検討2023
- Author(s)
  宮崎大吾
- Organizer
  第９回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07021
[Presentation] Muscle pathology of BMD mouse models carrying sever- and milder-form exon-deletions2023
- Author(s)
  Daigo Miyazaki
- Organizer
  第６４回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07021
[Presentation] A study on genome editing mouse models carrying exon-deletions of severe- and mild-form BMD2022
- Author(s)
  Daigo Miyazaki
- Organizer
  第６３回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07021
[Presentation] 重症度の異なる複数のベッカー型筋ジストロフィーモデルマウスを用いた重症化機序に関する研究2022
- Author(s)
  宮崎大吾
- Organizer
  第8回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07021
[Presentation] TMSB4X and IGF2 down-regulation in dystrophin-deficient cardiomyocyte derived from DMD2021
- Author(s)
  Daigo Miyazaki
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07064
[Presentation] Decrease of differentiation- and regeneration-related genes in dystrophin-deficient cardiomyocytes2020
- Author(s)
  Daigo Miyazaki
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07064
[Presentation] DMD患者由来心筋細胞における分化・再生関連遺伝子の発現低下と心筋障害への影響に関する研究2019
- Author(s)
  宮崎大吾、柴直子、佐藤充人、柴祐司、越後谷裕介、横田俊文、溝部吉高、青木吉嗣、武田伸一、中村昭則
- Organizer
  第14回筋ジストロフィー治療研究会
- Data Source
  KAKENHI-PROJECT-18H02577
[Presentation] DMD患者由来心筋細胞における分化・再生関連遺伝子の発現低下と心筋障害への影響に関する研究2019
- Author(s)
  宮崎大吾
- Organizer
  第14回筋ジストロフィー治療研究合同発表会
- Data Source
  KAKENHI-PROJECT-18K07064
[Presentation] DMD遺伝子exon46-55欠失変異を持つDMD患者iPSC由来心筋細胞に対するexon 45 skip治療に関する研究2019
- Author(s)
  佐藤充人、宮崎大吾、柴直子、柴祐司、越後谷裕介、横田俊文、青木吉嗣、武田伸一、中村昭則
- Organizer
  日本筋学会第5回学術集会
- Data Source
  KAKENHI-PROJECT-18H02577
[Presentation] Gene expression in cardiomyocytes from DMD with exon 46-55 deletion after exon 45 skipping therapy.2019
- Author(s)
  Miyazaki D., Sato M., Shiba N., Shiba Y., Echigoya Y., Yokota T., Aoki Y., Takeda S., Nakamura A.
- Organizer
  60th Annual Meeting of The Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-18H02577
[Presentation] Gene expression in cardiomyocytes from DMD with exon 46-55 deletion after exon 45 skipping therapy2019
- Author(s)
  Daigo Miyazaki
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07064
[Presentation] Decrease of genes associated with differentiation and regeneration in cardiomyocyte derived from DMD2018
- Author(s)
  Daigo Miyazaki
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07064
[Presentation] DMD患者iPS細胞由来の心筋細胞における分化・再生関連遺伝子の発現低下と心筋障害の発症機序に関する研究/Decrease of differentiation- and regeneration-associated genes in dystrophin-deficit cardiomyocyte derived from DMD2018
- Author(s)
  宮崎大吾
- Organizer
  日本筋学会第4回学術集会
- Data Source
  KAKENHI-PROJECT-18K07064
[Presentation] DMD患者iPS細胞由来の心筋細胞における分化・再生関連遺伝子の発現低下とエクソン・スキップ治療後の変化に関する研究2018
- Author(s)
  宮崎大吾
- Organizer
  第13回筋ジストロフィー治療研究合同発表会
- Data Source
  KAKENHI-PROJECT-18K07064
[Presentation] DMD遺伝子del.46-55変異を持つDMD患者のiPS細胞由来心筋細胞の作製と網羅的遺伝子発現解析2017
- Author(s)
  宮崎大吾、佐藤充人、柴祐司、越後谷裕介、横田俊文、青木吉嗣、武田伸一、中村昭則
- Organizer
  第3回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04756
[Presentation] Dystrophin-deficient cardiomyocytes derived from Duchenne muscular dystrophy-specific induced pluripotent stem cells carrying the deletion of exon 46-55 in the DMD gene2017
- Author(s)
  Miyazaki D, Sato M, Shiba Y, Echigoya Y, Yokota T, Aoki T, Takeda S, Nakamura A
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04756
[Presentation] DMD遺伝子del. 46-55変異を持つDMD患者のiPS細胞より誘導した心筋細胞に対するexon 45 skip治療2017
- Author(s)
  佐藤充人、宮崎大吾、柴祐司、越後谷裕介、横田俊文、青木吉嗣、武田伸一、中村昭則
- Organizer
  第3回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04756
[Presentation] The exon 45 skipping therapy of induced pluripotent stem cells from the DMD patient with exon 46-55 deletion2017
- Author(s)
  Sato M, Miyazaki D, Shiba Y, Echigoya Y, Yokota T, Aoki Y, Takeda S, Nakamura A
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04756
[Presentation] DMD患者iPS細胞由来の心筋細胞に対する網羅的遺伝子発現解析を用いた心筋障害の発症機序に関する研究2017
- Author(s)
  佐藤充人、宮崎大吾、柴祐司、越後谷裕介、横田俊文、青木吉嗣、武田伸一、中村昭則
- Organizer
  第12回筋ジストロフィー治療研究会
- Data Source
  KAKENHI-PROJECT-15H04756
[Presentation] DMD遺伝子del. 46-66変異を持つDMD患者のiPS細胞より誘導した心筋細胞に対するexon 45 skip治療に関する研究2016
- Author(s)
  佐藤充人、宮崎大吾、柴祐司、越後谷祐介、横田俊文、青木吉嗣、武田伸一、中村昭則
- Organizer
  第11回筋ジストロフィー治療研究合同発表会
- Place of Presentation
  松島（ホテル松島大観荘）
- Year and Date
  2016-10-29
- Data Source
  KAKENHI-PROJECT-15H04756
[Presentation] 筋障害モデルおよびジストロフィン欠損筋における MMP-9 の機能の解明2015
- Author(s)
  中村昭則、柴直子、宮崎大吾、福島和広
- Organizer
  第56回日本神経学会学術集会
- Place of Presentation
  新潟県新潟市　新潟コンベンションセンター
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26860792
[Presentation] Ablation of MMP-9 ameliorates the dystrophic phenotype by modulating chemotaxis in early stage but exacerbates fibrosis in late stage in mdx mice2015
- Author(s)
  Naoko Shiba, Daigo Miyazaki, Takahiro Yoshizawa, Kazuhiro Fukushima, Michihiro Imamura, Shin'ichi Takeda, Kenichi Koike, Akinori Nakamura
- Organizer
  20th International Congress of the World Muscle Society
- Place of Presentation
  Brighton, UK
- Year and Date
  2015-10-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860792
[Presentation] ジストロフィン欠損骨格筋におけるMatrix Metalloproteinase (MMP)-9の役割について2014
- Author(s)
  柴直子、宮崎大吾、福島和広、吉沢隆浩、中村昭則
- Organizer
  第9回筋ジストロフィー治療研究合同発表会
- Place of Presentation
  箱根湯元温泉吉池旅館
- Year and Date
  2014-11-01
- Data Source
  KAKENHI-PROJECT-26860792

1. Akinori Nakamura (10303471)

# of Collaborated Projects: 6 results

# of Collaborated Products: 16 results
2. SHIBA Naoko (00639289)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
3. 柴祐司 (70613503)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
4. YOSHIZAWA Takahiro (40713392)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 武田伸一 (90171644)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
6. FUKUSHIMA Kazuhiro (10421835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. 青木吉嗣 (80534172)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Miyazaki Daigo 宮崎 大吾

宮崎 大吾 ミヤザキ ダイゴ

MIYAZAKI Daigo 宮崎 大吾

Research Projects

Research Products

Co-Researchers

重症度の異なるゲノム編集マウスを用いた筋ジストロフィー重症化機序に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on pathogenesis and development of therapies for cardiac failure using dystrophin-deficient-cardiomyocytes derived from DMD patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of DMD exon 3-9 skipping therapy using iPSc

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of molecular targeted therapeutics for Duchenne muscular dystrophy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exon 45 skipping theraphy using iPS cells deleted exons 46-55 in the DMD gene

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the therapy for Duchenne muscular dystrophy targeting MMP-9

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DMD患者iPS細胞由来の心筋細胞における分化・再生関連遺伝子の発現低下と心筋障害の発症機序に関する研究2018

Author(s)

Journal Title

Data Source

[Journal Article] Comparison of the phenotypes of patients harboring in-frame deletions starting at exon 45 in the Duchenne muscular dystrophy gene indicates potential for the development of exon skipping therapy2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Differential roles of MMP-9 in early and late stages of dystrophic muscles in a mouse model of Duchenne muscular dystrophy2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] 重症度の異なるエクソン欠失を持つベッカー型筋ジストロフィーモデルマウスの表現型および病理学的比較検討2023

Author(s)

Organizer

Data Source

[Presentation] Muscle pathology of BMD mouse models carrying sever- and milder-form exon-deletions2023

Author(s)

Organizer

Data Source

[Presentation] A study on genome editing mouse models carrying exon-deletions of severe- and mild-form BMD2022

Author(s)

Organizer

Data Source

[Presentation] 重症度の異なる複数のベッカー型筋ジストロフィーモデルマウスを用いた重症化機序に関する研究2022

Author(s)

Organizer

Data Source

[Presentation] TMSB4X and IGF2 down-regulation in dystrophin-deficient cardiomyocyte derived from DMD2021

Author(s)

Miyazaki Daigo 宮崎大吾

宮崎大吾ミヤザキダイゴ

MIYAZAKI Daigo 宮崎大吾