Yamaguchi Takao 山口卓男

… Alternative Names

YAMAGUCHI Takao 山口卓男

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Researcher Number	80596601
Other IDs	https://orcid.org/0000-0003-3180-0257
Affiliation (Current)	2024: 大阪大学, 大学院薬学研究科, 講師
Affiliation (based on the past Project Information) *help	2024: 大阪大学, 大学院薬学研究科, 講師 2022: 大阪大学, 大学院薬学研究科, 講師 2019 – 2021: 大阪大学, 薬学研究科, 講師 2017: 大阪大学, 薬学研究科, 講師 2014 – 2016: 東京大学, 分子細胞生物学研究所, 助教
Review Section/Research Field	Principal Investigator Bio-related chemistry / Basic Section 37030:Chemical biology-related Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 47:Pharmaceutical sciences and related fields
Keywords	Principal Investigator タンパク質化学修飾 / アフィニティーラベル化 / 膜透過性 / 細胞膜 / 人工核酸 / 細胞内移行性 / 細胞膜透過性 / 核酸医薬 / オリゴ核酸 / ケミカルバイオロジー … More / アフィニティラベル化 / 標的同定 / 標的タンパク質 / 生物活性化合物 / 創薬化学 / 発蛍光プローブ分子 / 標的タンパク質同定 / 蛍光ラベル化 / 核酸アプタマー … More Except Principal Investigator 転写調節 / 大腸がん / ブロモドメイン / エピジェネティックリーダー / キナーゼ / がん融合遺伝子 / 人工アミノ酸 / クロスリンク / タンパク質間相互作用 / 融合型キナーゼ / がんゲノム Less

Development of novel cancer therapy based on the characteristics of epigenetic leaders that are upregulated in tumors
- Principal Investigator
  
  山口貴世志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  The University of Tokyo
Design and synthesis of membrane-permeable oligonucleotides and their application to therapeutic antisense oligonucleotidesPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Takao
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Osaka University
Analysis of cancer specific signaling cascade by in vivo protein photo-cross-linking approach
- Principal Investigator
  
  DOI Takefumi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University
Design of a novel affinity labeling probe exhibiting fluorescence and luminescencePrincipal Investigator
- Principal Investigator
  
  Yamaguchi Takao
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Osaka University
  The University of Tokyo
Selective labeling of target protein by using a chemical probe having a fluorogenic reactive group and an oligonucleotide aptamerPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Takao
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Patent

[Journal Article] Synthesis of multivalent fatty acid-conjugated antisense oligonucleotides: Cell internalization, physical properties, and in vitro and in vivo activities2023
- Author(s)
  Tanaka Yuya、Tanioku Yurika、Nakayama Taisuke、Aso Kotomi、Yamaguchi Takao、Kamada Haruhiko、Obika Satoshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 81 Pages: 117192-117192
- DOI
  10.1016/j.bmc.2023.117192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05748
[Journal Article] Synthesis and Properties of Nucleobase-Sugar Dual Modified Nucleic Acids: 2'-OMe-RNA and scpBNA Bearing a 5-Hydroxycytosine Nucleobase2022
- Author(s)
  Sakurai Yota、Yamaguchi Takao、Yoshida Tokuyuki、Horiba Masahiko、Inoue Takao、Obika Satoshi
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 88 Issue: 1 Pages: 154-162
- DOI
  10.1021/acs.joc.2c02038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05748, KAKENHI-PROJECT-20K12726
[Journal Article] Synthesis and properties of oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[Me]) bearing adenine, guanine, or 5-methylcytosine nucleobases2021
- Author(s)
  Horie Naohiro、Yamaguchi Takao、Kumagai Shinji、Obika Satoshi
- Journal Title
  
  Beilstein Journal of Organic Chemistry
  
  Volume: 17 Pages: 622-629
- DOI
  10.3762/bjoc.17.54
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J10308, KAKENHI-PROJECT-20K05748
[Journal Article] Synthesis and duplex-forming ability of oligonucleotides modified with 4′-C,5′-C-methylene-bridged nucleic acid (4′,5′-BNA)2021
- Author(s)
  Yamaguchi Takao、Yamamoto Chika、Horiba Masahiko、Aoyama Hiroshi、Obika Satoshi
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume: 46 Pages: 116359-116359
- DOI
  10.1016/j.bmc.2021.116359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05748
[Journal Article] Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold2020
- Author(s)
  Komine Hibiki、Mori Shohei、Morihiro Kunihiko、Ishida Kenta、Okuda Takumi、Kasahara Yuuya、Aoyama Hiroshi、Yamaguchi Takao、Obika Satoshi
- Journal Title
  
  Molecules
  
  Volume: 25 Issue: 7 Pages: 1732-1732
- DOI
  10.3390/molecules25071732
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05748
[Journal Article] Synthesis and properties of GuNA purine/pyrimidine nucleosides and oligonucleotides2020
- Author(s)
  Kumagai Shinji、Sawamoto Hiroaki、Takegawa-Araki Tomo、Arai Yuuki、Yamakoshi Shuhei、Yamada Katsuya、Ohta Tetsuya、Kawanishi Eiji、Horie Naohiro、Yamaguchi Takao、Obika Satoshi
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 18 Issue: 46 Pages: 9461-9472
- DOI
  10.1039/d0ob01970d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05748
[Journal Article] Photo-enhanced aqueous solubilization of an azo-compound2017
- Author(s)
  Minoru Ishikawa, Takuya Ohzono, Takao Yamaguchi, Yasuo Norikane
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 6909-6909
- DOI
  10.1038/s41598-017-06947-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-16K17930
[Journal Article] Specific fluorescence labeling of target protein by using ligand-4-azidophthalimide conjugate2017
- Author(s)
  Kosuke Chiba, Miwako Asanuma, Minoru Ishikawa, Yuichi Hashimoto, Kosuke Dodo, Mikiko Sodeoka, Takao Yamaguchi
- Journal Title
  
  Chemical Communications
  
  Volume: 53 Issue: 62 Pages: 8751-8754
- DOI
  10.1039/c7cc03252h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-16K17930
[Journal Article] Synthesis and evaluation of novel dual BRD4/HDAC inhibitors2017
- Author(s)
  Amemiya Seika、Yamaguchi Takao、Hashimoto Yuichi、Noguchi-Yachide Tomomi
- Journal Title
  
  Bioorganig and Medicinal Chemistry
  
  Volume: 25 Issue: 14 Pages: 3677-3684
- DOI
  10.1016/j.bmc.2017.04.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K17930
[Journal Article] Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists2017
- Author(s)
  Ryuta Shioi, Shogo Okazaki, Tomomi Noguchi-Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 27 Issue: 14 Pages: 3131-3134
- DOI
  10.1016/j.bmcl.2017.05.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K17930
[Journal Article] Development of N6-(heteroarylcarbonyl)adenines as BRD4 inhibitors.2017
- Author(s)
  Seika Amemiya、Takao Yamaguchi、Yuichi Hashimoto、 Tomomi Noguchi-Yachide
- Journal Title
  
  Heterocycles
  
  Volume: 94 Issue: 6 Pages: 1107-1114
- DOI
  10.3987/com-17-13667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K17930
[Journal Article] Structural Development Studies of Pyrazoloketone-Derived Acetyl-CoA Carboxylase Inhibitors2017
- Author(s)
  Shogo Okazaki, Taki Sakai, Minoru Ishikawa, Yuichi Hashimoto, Takao Yamaguchi
- Journal Title
  
  Heterocycles
  
  Volume: 95 Issue: 1 Pages: 595-607
- DOI
  10.3987/com-16-s(s)30
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K17930, KAKENHI-PROJECT-25293027
[Journal Article] Affinity Labeling with 4-Azidophthalimide (AzPI): Relation between Labeling Rate and Fluorescence Intensity2017
- Author(s)
  Kosuke Chiba, Yuichi Hashimoto, Takao Yamaguchi
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 65 Issue: 10 Pages: 994-996
- DOI
  10.1248/cpb.c17-00546
- NAID
  130006109935
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K17930
[Journal Article] Three-Dimensional QSAR Analysis and Design of New 1,2,4-Oxadiazole Antibiotics2016
- Author(s)
  Erika Leemans, Kiran V. Mahasenan, Malika Kumarasiri, Edward Spink, Derong Ding, Peter I. O’Daniel, Marc A. Boudreau, Elena Lastochkin, Sebastian A. Testero, Takao Yamaguchi, Mijoon Lee, Dusan Hesek, Jed F. Fisher, Mayland Chang, Shahriar Mobashery
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 26 Issue: 3 Pages: 1011-1015
- DOI
  10.1016/j.bmcl.2015.12.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26810091
[Journal Article] Dichloromaleimide (diCMI): A Small and Fluorogenic Reactive Group for Use in Affinity Labeling2016
- Author(s)
  Kosuke Chiba, Yuichi Hashimoto, Takao Yamaguchi
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 64 Issue: 11 Pages: 1647-1653
- DOI
  10.1248/cpb.c16-00501
- NAID
  130005268074
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K17930
[Journal Article] Structure-activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptorα/δ (PPARα/δ) dual agonists2016
- Author(s)
  Shogo Okazaki, Ryuta Shioi, Tomomi Noguchi-Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 24 Issue: 21 Pages: 5455-5461
- DOI
  10.1016/j.bmc.2016.08.067
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K17930
[Journal Article] Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activit2016
- Author(s)
  Shogo Okazaki, Tomomi Noguchi-Yachide, Taki Sakai, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 24 Issue: 21 Pages: 5258-5269
- DOI
  10.1016/j.bmc.2016.08.045
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K15137, KAKENHI-PROJECT-16K17930
[Journal Article] Synthesis of scpBNA‐mC, -A, and -G Monomers and Evaluation of the Binding Affinities of scpBNA-Modified Oligonucleotides toward Complementary ssRNA and ssDNA2016
- Author(s)
  Masahiko Horiba, Takao Yamaguchi, Satoshi Obika
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 81 Issue: 22 Pages: 11000-11008
- DOI
  10.1021/acs.joc.6b02036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J06367, KAKENHI-PROJECT-16K17930
[Journal Article] Discovery and structure-;activity relationship studies of N6-benzoyladenine derivatives as novel BRD4 inhibitors2015
- Author(s)
  Noguchi-Yachide, T., Sakai, T., Hashimoto, Y., Yamaguchi, Y.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 23 Issue: 5 Pages: 953-959
- DOI
  10.1016/j.bmc.2015.01.022
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293025, KAKENHI-PROJECT-26810091, KAKENHI-PROJECT-15K08015
[Journal Article] Synthesis and Properties of 2’-O,4’-C-Spirocyclopropylene Bridged Nucleic Acid (scpBNA), an Analogue of 2’,4’-BNA/LNA Bearing a Cyclopropane Ring.2015
- Author(s)
  Yamaguchi T., Horiba M., Obika S.
- Journal Title
  
  Chem. Commun.
  
  Volume: 23 Issue: 47 Pages: 33-37
- DOI
  10.1039/c5cc02024g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-26810091
[Journal Article] Synthesis and fluorescence properties of 4-diarylmethylene analogues of the green fluorescent protein chromophore2015
- Author(s)
  Masahiro Ikejiri, Kousuke Matsumoto, Hiraku Hasegawa, Daisuke Yamaguchi, Moe Tsuchino, Yoshiko Chihara, Takao Yamaguchi, Kazuto Mori, Takeshi Imanishi, Satoshi Obika, Kazuyuki Miyashita
- Journal Title
  
  Tetrahedron
  
  Volume: 71 Issue: 30 Pages: 4987-4998
- DOI
  10.1016/j.tet.2015.05.073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26810091
[Journal Article] Exploration of the Structure-Activity Relationship of 1,2,4-Oxadiazole Antibiotics2015
- Author(s)
  Derong Ding, Marc A. Boudreau, Erika Leemans, Edward Spink, Takao Yamaguchi, Sebastian A. Testero, Peter I. O’Daniel, Elena Lastochkin, Mayland Chang, Shahriar Mobashery
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 25 Issue: 21 Pages: 4854-4857
- DOI
  10.1016/j.bmcl.2015.06.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26810091
[Patent] 5’位修飾ヌクレオシドおよびそれを用いたヌクレオチド2022
- Inventor(s)
  小比賀聡、山口卓男、阪上詩織、井上貴雄、吉田徳幸
- Industrial Property Rights Holder
  小比賀聡、山口卓男、阪上詩織、井上貴雄、吉田徳幸
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20K05748
[Patent] 架橋型ヌクレオシドおよびそれを用いたヌクレオチド2021
- Inventor(s)
  小比賀聡、山口卓男、小峯飛々暉、など
- Industrial Property Rights Holder
  小比賀聡、山口卓男、小峯飛々暉、など
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-20K05748
[Patent] 架橋型ヌクレオシドおよびそれを用いたヌクレオチド2021
- Inventor(s)
  小比賀聡、山口卓男、櫻井耀太、など
- Industrial Property Rights Holder
  小比賀聡、山口卓男、櫻井耀太、など
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-20K05748
[Patent] 架橋型ヌクレオシドおよびヌクレオチド2015
- Inventor(s)
  小比賀聡、山口卓男、堀場昌彦、脇玲子
- Industrial Property Rights Holder
  小比賀聡、山口卓男、堀場昌彦、脇玲子
- Industrial Property Rights Type
  特許
- Filing Date
  2015-02-17
- Overseas
- Data Source
  KAKENHI-PROJECT-26810091
[Presentation] 2'-O,4'-C-スピロシクロペンチレン架橋核酸のグアニン誘導体の合成2023
- Author(s)
  熊谷陸、杉浦隆也、小峯飛々暉、山口卓男、小比賀聡
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] いま注目される核酸医薬　－アンチセンス核酸の魅力－2023
- Author(s)
  山口卓男
- Organizer
  CPHI Japan 2023
- Invited
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 核酸医薬の基礎から最新の研究動向まで2023
- Author(s)
  山口卓男
- Organizer
  日本薬学会第143年会ランチョンセミナー（東ソー株式会社）
- Invited
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 核酸医薬の基礎と分析ニーズ2023
- Author(s)
  山口卓男
- Organizer
  ニューモダリティ医薬のLC/MS分析フォーラム（日本ウォーターズ株式会社）
- Invited
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 5′-シクロプロピレン修飾核酸の合成と機能評価2022
- Author(s)
  山口卓男、羽渕貴紀、杉浦隆也、加藤剛、吉田徳幸、井上貴雄、小比賀聡
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] オリゴ核酸分析における超臨界流体クロマトグラフィーの利用：添加剤濃度の検討2022
- Author(s)
  林田桃香、鈴木里沙、堀江真之介、山口卓男、小比賀聡
- Organizer
  第29回クロマトグラフィーシンポジウム
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] Investigation of supercritical fluid chromatography (SFC) analytical conditions for oligonucleotides2022
- Author(s)
  Momoka Hayashida, Shinnosuke Horie, Takao Yamaguchi, Satoshi Obika
- Organizer
  33rd International Symposium on Chromatography
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 5'位にシクロペンタン環を有する新規修飾核酸の合成とその物性評価2022
- Author(s)
  阪上詩織、小峯飛々暉、山口卓男、吉田徳幸、井上貴雄、小比賀聡
- Organizer
  日本薬学会　第142回年会
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 5位にアミノメチル基を有するピリミジン塩基の合成と特性解析2022
- Author(s)
  松村朋紀、山口卓男、小比賀聡
- Organizer
  日本薬学会　第142回年会
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] Synthesis and properties of 1′-C,3′-O-butylene-bridged D-altritol nucleic acid2022
- Author(s)
  Kei Sugita, Chika Yamamoto, Yota Sakurai, Takao Yamaguchi, Satoshi Obika
- Organizer
  The 49th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] Fatty acid and cell-penetrating motif conjugation for efficient intracellular delivery of antisense oligonucleotides2022
- Author(s)
  Yuya Tanaka, Yurika Tanioku, Kotomi Aso, Takao Yamaguchi, Satoshi Obika
- Organizer
  18th Annual Meeting of the Oligonucleotide Therapeutics Society (OTS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] オリゴ核酸分析における超臨界流体クロマトグラフィーの可能性検討2022
- Author(s)
  林田桃香、鈴木里沙、堀江真之介、山口卓男、小比賀聡
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 核酸医薬の基礎から最先端まで2022
- Author(s)
  山口卓男
- Organizer
  生命科学研究科セミナー（東北大学）
- Invited
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 新規人工核酸の導入によるアンチセンス核酸の毒性軽減2022
- Author(s)
  山口卓男
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 1′-C,3′-O-架橋型 D-アルトリトール核酸の合成と機能評価2022
- Author(s)
  山口卓男、櫻井耀太、山本知佳、杉田慧、吉田徳幸、井上貴雄、小比賀聡
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 二重鎖形成を利用した標的タンパク質のラベル化と精製法の開発2022
- Author(s)
  吉田匠、山口卓男、小比賀聡
- Organizer
  日本薬学会　第142回年会
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] Synthesis and evaluation of antisense oligonucleotides multiply conjugated with hexose-type sugar monomers2021
- Author(s)
  Yurika Tanioku, Yuya Tanaka, Yuuya Kasahara, Taisuke Nakayama, Haruhiko Kamada, Takao Yamaguchi, Satoshi Obika
- Organizer
  The 48th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 複数導入可能な脂質アミダイトの合成とそのアンチセンス核酸への応用2021
- Author(s)
  田中佑弥、谷奥有里花、阿曽古都美、中山泰亮、鎌田春彦、山口卓男、小比賀聡
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] Robust synthetic approach of oligonucleotides modified with N-(tert-butyl) guanidine-bridged nucleic acid2021
- Author(s)
  Ryusuke Hatanaka, Naohiro Horie, Takao Yamaguchi, Masaki Yamagami, Tadashi Umemoto, Satoshi Obika
- Organizer
  17th Oligonucleotide Therapeutics Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 二重鎖副溝との相互作用を志向した疎水性置換基を有する新規架橋型人工核酸の開発2021
- Author(s)
  畑中隆佑、堀江直宏、山口卓男、小比賀聡
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] Effect of multivalent fatty acid conjugation on the activity and membrane permeability of antisense oligonucleotides2021
- Author(s)
  Yuya Tanaka, Yurika Tanioku, Kotomi Aso, Taisuke Nakayama, Haruhiko Kamada, Takao Yamaguchi, Satoshi Obika
- Organizer
  The 48th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] Synthesis and Evaluation of 1′,3′-Bridged Altritol Nucleic Acids (BANAs)2021
- Author(s)
  Chika Yamamoto, Yota Sakurai, Takao Yamaguchi, Tokuyuki Yoshida, Takao Inoue, Satoshi Obika
- Organizer
  17th Oligonucleotide Therapeutics Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 5'-シクロプロピレン修飾型アンチセンス核酸の合成と活性評価2021
- Author(s)
  杉浦隆也、羽渕貴紀、山口卓男、吉田徳幸、井上貴雄、小比賀聡
- Organizer
  創薬懇話会2021 in 京都
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 1′,3′-プロピレンオキシ架橋型ピラノースを母核とする新規人工核酸の創製2021
- Author(s)
  山本知佳、櫻井耀太、山口卓男、小比賀聡
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] Synthesis and biophysical properties of 1',3'-bridged D-altritol nucleic acids (BANAs)2021
- Author(s)
  Takao Yamaguchi, Yota Sakurai, Chika Yamamoto, Tokuyuki Yoshida, Takao Inoue, Satoshi Obika
- Organizer
  PacifiChem 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] アンチセンス核酸医薬開発における人工核酸の役割2021
- Author(s)
  山口卓男
- Organizer
  理研セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 核酸医薬の創製：人工核酸が切り拓く有効性と安全性の両立2021
- Author(s)
  山口卓男
- Organizer
  創薬懇話会2021 in 京都
- Invited
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 1’位と3’位間をブチレン架橋したアルトリトール核酸の合成と機能2021
- Author(s)
  杉田慧、山本知佳、山口卓男、小比賀聡
- Organizer
  第71回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] タンパク質間相互作用界面の同定を可能にする新規光架橋性人工アミノ酸の開発2021
- Author(s)
  高田理彩，樋野展正，山口卓男，深田宗一朗，土井健史
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] Synthesis of 4',5'-bridged nucleic acid having distorted torsion angle γ2021
- Author(s)
  Chika Yamamoto, Masahiko Horiba, Hiroshi Aoyama, Takao Yamaguchi, Satoshi Obika
- Organizer
  PacifiChem 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 2’位に疎水性置換基を配置した新規架橋型人工核酸の二重鎖形成能2021
- Author(s)
  畑中隆佑、堀江直宏、山口卓男、小比賀聡
- Organizer
  日本核酸医薬学会　第6回年会
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] Facile synthesis of oligonucleotides modified with N-tert-butylguanidine-bridged nucleic acid2021
- Author(s)
  Ryusuke Hatanaka, Naohiro Horie, Takao Yamaguchi, Masaki Yamagami, Tadashi Umemoto, Satoshi Obika
- Organizer
  PacifiChem 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] スピロシクロペンチレン架橋を有する人工核酸の合成及び物性評価2021
- Author(s)
  杉浦隆也、小峯飛々暉、山口卓男、小比賀聡
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] リガンド結合型オリゴ核酸と相補的オリゴ核酸プローブの二重鎖形成を利用した標的タンパク質同定2020
- Author(s)
  吉田匠、山口卓男、小比賀聡
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 標的臓器へのデリバリーを志向した糖コンジュゲート型オリゴ核酸の合成2020
- Author(s)
  谷奥有里花、山口卓男、小比賀聡
- Organizer
  第70回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 5'位にシクロプロパン環を有する2',4'-架橋型人工核酸の合成と物性評価2020
- Author(s)
  浅田和輝、羽渕貴紀、杉浦隆也、山口卓男、小比賀聡
- Organizer
  第70回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K05748
[Presentation] 薬物標的タンパク質の同定を志向した新規アフィニティーラベル化法の開発2019
- Author(s)
  山口卓男
- Organizer
  第69回日本薬学会関西支部総会・大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 各種置換基を導入したグアニジン架橋型人工核酸の合成2018
- Author(s)
  堀江直宏、山口卓男、小比賀聡
- Organizer
  日本化学会　第98春季年会（2018）
- Data Source
  KAKENHI-PROJECT-16K17930
[Presentation] 5位に水酸基を有する2'-O-メチルシチジン誘導体の合成2018
- Author(s)
  櫻井耀太、堀場昌彦、山口卓男、小比賀聡
- Organizer
  日本薬学会　第138回年会
- Data Source
  KAKENHI-PROJECT-16K17930
[Presentation] 標的タンパク質のリン酸化を選択的に誘導する分子の創製2017
- Author(s)
  境太希、岡崎翔吾、石川稔、橋本祐一、山口卓男
- Organizer
  日本薬学会第137回年会
- Place of Presentation
  東北大学、仙台国際センター、仙台市民会館（宮城県・仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K17930
[Presentation] エステラーゼ活性評価のための蛍光turn-ON型プローブ分子の創製2017
- Author(s)
  岡田佳那、山口卓男、どど孝介、袖岡幹子、小比賀聡
- Organizer
  第67回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-16K17930
[Presentation] アジドフタルイミドを用いる新規標的タンパク質同定法の創出2016
- Author(s)
  千葉幸介、橋本祐一、山口卓男
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学大学院薬学研究科（東京都・文京区）
- Data Source
  KAKENHI-PROJECT-16K17930
[Presentation] アジドフタルイミドを用いた発蛍光型光アフィニティーラベル化法の開発2016
- Author(s)
  千葉幸介、橋本祐一、山口卓男
- Organizer
  日本ケミカルバイオロジー学会　第11回年会
- Place of Presentation
  京都テルサ（京都府・京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16K17930
[Presentation] PPARα/δデュアル転写誘導活性を有する新規ACC2阻害剤の創出2016
- Author(s)
  山口卓男、岡崎翔吾、境太希、谷内出友美、石川稔、橋本祐一
- Organizer
  日本ケミカルバイオロジー学会　第11回年会
- Place of Presentation
  京都テルサ（京都府・京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16K17930
[Presentation] アジドフタルイミドを発蛍光性光反応基とする新規アフィニティーラベル化法の開発2016
- Author(s)
  千葉幸介、橋本祐一、山口卓男
- Organizer
  日本薬学会　第136回年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26810091
[Presentation] Specific Fluorescence Labeling of a Target Protein Utilizing a Single, Small, Non-Fluorescent Unit2015
- Author(s)
  Takao Yamaguchi, Kosuke Chiba, Yuichi Hashimoto, Kosuke Dodo, Miwako Asanuma, Mikiko Sodeoka
- Organizer
  Tokyo-LUM Symposium
- Place of Presentation
  Ludwig-Maximilians-Universitat（ドイツ・バイエルン州・ミュンヘン市）
- Year and Date
  2015-10-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26810091
[Presentation] Synthesis and properties of oligonucleotides containing 2’-O,4’-C-spirocyclopropylene bridged nucleic acids (scpBNA) having pyrimidine bases2015
- Author(s)
  Masahiko Horiba, Takao Yamaguchi, Reiko Waki, Satoshi Obika
- Organizer
  SKO Symposium 2015
- Place of Presentation
  Seoul National University（韓国・ソウル市）
- Year and Date
  2015-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26810091
[Presentation] スピロシクロプロパン構造を導入した新規架橋型人工核酸の合成と物性評価2015
- Author(s)
  堀場昌彦、山口卓男、小比賀聡
- Organizer
  第41回反応と合成の進歩シンポジウム
- Place of Presentation
  近畿大学 11月ホール（大阪府・東大阪市）
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-26810091
[Presentation] 新規PPARαアゴニストの探索と構造展開、およびhACC2阻害活性評価2015
- Author(s)
  岡崎翔吾、境太希、谷内出友美、石川稔、橋本祐一、山口卓男
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研修センター（千葉県・千葉市）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26810091
[Presentation] Synthesis and biophysical evaluation of 2’-O,4’-C-Spirocyclopropylene Bridged Nucleic Acids (scpBNA)
- Author(s)
  Masahiko Horiba, Takao Yamaguchi, Satoshi Obika
- Organizer
  第41回国際核酸化学シンポジウム
- Place of Presentation
  福岡、北九州国際会議場
- Year and Date
  2014-11-05 – 2014-11-07
- Data Source
  KAKENHI-PROJECT-26810091
[Presentation] ニトロベンゾオキサジアゾールを用いる蛍光turn-ON型アフィニティーラベル化法の開発
- Author(s)
  山口卓男、淺沼三和子、中西修一、斎藤洋平、岡﨑正晃、どど孝介、袖岡幹子
- Organizer
  第12回次世代を担う有機化学シンポジウム
- Place of Presentation
  東京、日本薬学会長井記念ホール
- Year and Date
  2014-05-23 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26810091
[Presentation] 蛍光turn-ON型ラベル化法を用いた生物活性化合物の標的タンパク質の解析
- Author(s)
  淺沼三和子、どど孝介、山口卓男、中西修一、斎藤洋平、岡﨑正晃、袖岡幹子
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都、国立京都国際会館
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26810091

1. DOI Takefumi (00211409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 樋野展正 (90469916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 山口貴世志 (50466843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 小沢学 (80608787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NOGUCHI Tomomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. ISHIKAWA Minoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
7. 橋本祐一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 小比賀聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamaguchi Takao 山口 卓男

YAMAGUCHI Takao 山口 卓男

Research Projects

Research Products

Co-Researchers

Development of novel cancer therapy based on the characteristics of epigenetic leaders that are upregulated in tumors

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Design and synthesis of membrane-permeable oligonucleotides and their application to therapeutic antisense oligonucleotidesPrincipal Investigator

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Analysis of cancer specific signaling cascade by in vivo protein photo-cross-linking approach

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Design of a novel affinity labeling probe exhibiting fluorescence and luminescencePrincipal Investigator

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Selective labeling of target protein by using a chemical probe having a fluorogenic reactive group and an oligonucleotide aptamerPrincipal Investigator

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[Journal Article] Synthesis of multivalent fatty acid-conjugated antisense oligonucleotides: Cell internalization, physical properties, and in vitro and in vivo activities2023

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[Journal Article] Synthesis and Properties of Nucleobase-Sugar Dual Modified Nucleic Acids: 2'-OMe-RNA and scpBNA Bearing a 5-Hydroxycytosine Nucleobase2022

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[Journal Article] Synthesis and properties of oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[Me]) bearing adenine, guanine, or 5-methylcytosine nucleobases2021

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[Journal Article] Synthesis and duplex-forming ability of oligonucleotides modified with 4′-C,5′-C-methylene-bridged nucleic acid (4′,5′-BNA)2021

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[Journal Article] Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold2020

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[Journal Article] Synthesis and properties of GuNA purine/pyrimidine nucleosides and oligonucleotides2020

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[Journal Article] Photo-enhanced aqueous solubilization of an azo-compound2017

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[Journal Article] Specific fluorescence labeling of target protein by using ligand-4-azidophthalimide conjugate2017

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[Journal Article] Synthesis and evaluation of novel dual BRD4/HDAC inhibitors2017

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Yamaguchi Takao 山口卓男

YAMAGUCHI Takao 山口卓男