Tamehiro Norimasa 為広紀正

… Alternative Names

TAMEHIRO Norimasa 為広紀正

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Researcher Number	80597881
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, 生化学部, 室長
Affiliation (based on the past Project Information) *help	2023 – 2024: 国立医薬品食品衛生研究所, 生化学部, 室長 2021 – 2022: 国立医薬品食品衛生研究所, 生化学部, 協力研究員 2017 – 2020: 国立医薬品食品衛生研究所, 生化学部, 主任研究官 2015: 国立国際医療研究センター, 研究所, 上級研究員 2014 – 2015: 国立研究開発法人国立国際医療研究センター, 研究所, 上級研究員 2012 – 2013: 独立行政法人国立国際医療研究センター, その他部局等, その他
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Eating habits / Immunology Except Principal Investigator Basic Section 38050:Food sciences-related / Basic Section 49030:Experimental pathology-related / Basic Section 43060:System genome science-related / Immunology
Keywords	Principal Investigator 食物アレルギー / 動物モデル / 制御性T細胞 / モデルマウス / アレルギー / 食品機能性分子 / 脱顆粒 / IgE / マスト細胞 / 乾癬 / T細胞 … More Except Principal Investigator … More Themis / 自然言語処理 / 機械学習 / アレルゲン予測 / ヒト疾患モデル / コンディショナル遺伝子欠損マウス / 遺伝子欠損マウス / 皮膚炎 / 眼瞼炎 / 自然発症 / CRISPR / DNA２本鎖切断 / 細胞周期 / レポーター細胞 / DNA修復 / ゲノム編集 / 制御性T細胞 / 免疫学 / Grb2 / 核 / シグナル伝達 / TCR / 胸腺 / T細胞 Less

Development of food-allergy prediction system using large language model
- Principal Investigator
  
  近藤一成
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Showa Women's University
Development of cell-cycle-regulated CRISPR/Cas system
- Principal Investigator
  
  近藤一成
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  Showa Women's University
  National Institute of Health Sciences
皮膚炎を自然発症するBalb/c背景Themis遺伝子欠損マウスの解析
- Principal Investigator
  
  宮崎幸造
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  National Center for Global Health and Medicine
The role of regulatory T cells in tolerance to food allergy.Principal Investigator
- Principal Investigator
  
  為広紀正
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  National Institute of Health Sciences
Research for signaling molecules that regulate mast cell-mediated allergic reactionsPrincipal Investigator
- Principal Investigator
  
  Tamehiro Norimasa
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  National Institute of Health Sciences
Studies on nuclear signaling proteins required for T cell development
- Principal Investigator
  
  Nitta Takeshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
  独立行政法人国立国際医療研究センター
Development of psoriasis-like chronic dermatitis in RhoH deficient micePrincipal Investigator
- Principal Investigator
  
  TAMEHIRO Norimasa
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  独立行政法人国立国際医療研究センター

All 2023 2022 2020 2019 2018 2017 2015 2014 2013 2012 Other

All Journal Article Presentation Book

[Book] Models of Allergic Disease（Series: Methods in Molecular Biology）2020
- Author(s)
  Tamehiro N., Adachi R., Kondo K.
- Total Pages
  11
- Publisher
  Springer Nature
- Data Source
  KAKENHI-PROJECT-17K00907
[Journal Article] Novel machine learning method allerStat identifies statistically significant allergen-specific patterns in protein sequences2023
- Author(s)
  Goto K, Tamehiro N, Yoshida T, Hanada H, Sakuma T, Adachi R, Kondo K, Takeuchi I.
- Journal Title
  
  J Biol Chem.
  
  Volume: 299 Issue: 6 Pages: 104733-104733
- DOI
  10.1016/j.jbc.2023.104733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08468, KAKENHI-PROJECT-20K19905
[Journal Article] Real-time PCR Detection Methods for Food Allergens (Wheat, Buckwheat, and Peanuts) Using Reference Plasmids.2019
- Author(s)
  Miyazaki A, Watanabe S, Ogata K, Nagatomi Y, Kokutani R, Minegishi Y, Tamehiro N, Sakai S, Adachi R, Hirao T.
- Journal Title
  
  J Agric Food Chem.
  
  Volume: 67 Pages: 5680-5680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K00907
[Journal Article] Ras homolog gene family H (RhoH) deficiency induces psoriasis-like chronic dermatitis by promoting TH17 cell polarization.2019
- Author(s)
  Tamehiro N, Nishida K, Sugita Y, Hayakawa K, Oda H, Nitta T, Nakano M, Nishioka A, Yanobu-Takanashi R, Goto M, Okamura T, Adachi R, Kondo K, Morita A, Suzuki H.
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 143 Pages: 1878-1878
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K00907
[Journal Article] Cross-allergenicity of crustacean and the edible insect Gryllus bimaculatus in patients with shrimp allergy.2019
- Author(s)
  Kamemura N, Sugimoto M, Tamehiro N, Adachi R, Tomonari S, Watanabe T, Mito T.
- Journal Title
  
  Mol Immunol.
  
  Volume: 106 Pages: 127-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K00907
[Journal Article] Determining Food Allergens by Skin Sensitization in Mice.2018
- Author(s)
  Tamehiro N, Adachi R, Kimura Y, Sakai S, Teshima R, Kondo K
- Journal Title
  
  Curr Protoc Toxicol.
  
  Volume: 76 Issue: 1
- DOI
  10.1002/cptx.48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K00907, KAKENHI-PROJECT-15K08061
[Journal Article] T-cell activation RhoGTPase-activating protein plays an important role in TH17-cell differentiation.2017
- Author(s)
  Tamehiro N, Nishida K, Yanobu-Takanashi R, Goto M, Okamura T, Suzuki H.
- Journal Title
  
  Immunol Cell Biol.
  
  Volume: 95 Issue: 8 Pages: 729-735
- DOI
  10.1038/icb.2017.27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K00907
[Journal Article] LXR Agonism Upregulates the Macrophage ABCA1/Syntrophin Protein Complex That Can Bind ApoA-I and Stabilized ABCA1 Protein, but Complex Loss Does Not Inhibit Lipid Efflux.2015
- Author(s)
  Tamehiro N, Park MH, Hawxhurst V, Nagpal K, Adams ME, Zannis VI, Golenbock DT, Fitzgerald ML
- Journal Title
  
  Biochemistry
  
  Volume: 54 Issue: 46 Pages: 6931-6941
- DOI
  10.1021/acs.biochem.5b00894
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460606
[Journal Article] Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.2015
- Author(s)
  Tamehiro N, Oda H, Shirai M, Suzuki H.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 6 Pages: e0131047-e0131047
- DOI
  10.1371/journal.pone.0131047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09568, KAKENHI-PROJECT-25460606, KAKENHI-PROJECT-25871164
[Journal Article] Differential Function of Themis CABIT Domains during T Cell Development.2014
- Author(s)
  Okada T, Nitta T, Kaji K, Takashima A, Oda H, Tamehiro N, Goto M, Okamura T, Patrick MS, Suzuki H.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 2 Pages: e89115-e89115
- DOI
  10.1371/journal.pone.0089115
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-24790491, KAKENHI-PROJECT-25460606, KAKENHI-PROJECT-25871164
[Journal Article] Differential requirement for RhoH in development of TCRαβ CD8αα IELs and other types of T cells.2013
- Author(s)
  Oda, H.
- Journal Title
  
  Immunol Lett.
  
  Volume: 151 Issue: 1-2 Pages: 1-9
- DOI
  10.1016/j.imlet.2013.02.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390098, KAKENHI-PROJECT-23790554, KAKENHI-PROJECT-24790491
[Presentation] 眼瞼炎を自然発症するThemis欠損マウスの解析2022
- Author(s)
  宮崎幸造、為広紀正、北島雅之、木村彰宏、佐藤真理、小川葉子、根岸一乃、鈴木春巳
- Organizer
  NCGM夏季リトリート2022
- Data Source
  KAKENHI-PROJECT-21K06959
[Presentation] Functional food ingredients modulate mast cell signaling2020
- Author(s)
  Tamehiro N., Adachi R., Kondo K.
- Organizer
  JSA/WAO Joint Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K00907
[Presentation] マスト細胞機能制御における分子機構の解析2019
- Author(s)
  為広紀正、安達玲子、廣實慶彦、近藤一成
- Organizer
  アレルギー学会
- Data Source
  KAKENHI-PROJECT-17K00907
[Presentation] コチニールアレルギーモデルを用いたアレルギー病態の解析2018
- Author(s)
  為広紀正、安達玲子、近藤一成
- Organizer
  アレルギー学会
- Data Source
  KAKENHI-PROJECT-17K00907
[Presentation] EXiLE法によるコチニールアレルギー患者IgEの抗原性解析2017
- Author(s)
  為広紀正、安達玲子、中村政志、竹尾直子、山口正雄、安達玲子、中村政志、竹尾直子、山口正雄、中村亮介、永井晶代、矢上晶子、松永佳世子、近藤一成
- Organizer
  日本アレルギー学会
- Data Source
  KAKENHI-PROJECT-17K00907
[Presentation] Differential roles of TCR-proximal signaling adaptors in T cell development2015
- Author(s)
  Harumi Suzuki, Norimasa Tamehiro, Ryunosuke Muro, Hiroyo Oda, Takeshi Nitta, Akihiro Kimura
- Organizer
  第44回日本免疫学会総会・学術集会
- Place of Presentation
  札幌市
- Year and Date
  2015-11-18
- Invited
- Data Source
  KAKENHI-PROJECT-25460606
[Presentation] RhoH is essential for development of IL-17-producing γδ T cells2015
- Author(s)
  Ryunosuke Muro, Takeshi Nitta, Norimasa Tamehiro, Hiroyo Oda, Harumi Suzuki
- Organizer
  第44回日本免疫学会総会・学術集会
- Place of Presentation
  札幌市
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25460606
[Presentation] Post - translational regulation of RhoH via the proteasomal pathway2014
- Author(s)
  Norimasa Tamehiro
- Organizer
  99th Annual Meeting The American Association of Immunologists
- Place of Presentation
  Boston
- Year and Date
  2014-05-06
- Data Source
  KAKENHI-PROJECT-24790491
[Presentation] Over expression of RhoH activates the transition of CD4-CD8-(DN) to CD4+CD8+ (DP) cells in RAG-/- background.2014
- Author(s)
  Norimasa Tamehiro, Hiroyo Oda, and Harumi Suzuki
- Organizer
  第４３回日本免疫学会学術集会
- Place of Presentation
  京都市
- Year and Date
  2014-12-10
- Data Source
  KAKENHI-PROJECT-25460606
[Presentation] A non - synonymous SNP variant of RhoH reduces TCR mediated signal transduction via proteasomal degradation2013
- Author(s)
  Norimasa Tamehiro
- Organizer
  日本免疫学会総会
- Place of Presentation
  幕張
- Year and Date
  2013-12-11
- Data Source
  KAKENHI-PROJECT-24790491
[Presentation] A non-synonymous SNP variant of RhoH reduces TCR mediated signal transduction via proteasomal degradation2013
- Author(s)
  Norimasa Tamehiro, Hiroyo Oda, Harumi Suzuki
- Organizer
  日本免疫学会　総会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-24790491
[Presentation] Post-translational regulation of RhoH via the proteasomal pathway2012
- Author(s)
  Norimasa Tamehiro, Hiroyo Oda and Harumi Suzuki
- Organizer
  99th Annual Meeting, The American Association of Immunologists
- Place of Presentation
  ボストン
- Data Source
  KAKENHI-PROJECT-24790491
[Presentation] TCR-dependent proteasomal degradation of RhoH in CD4CD8 double positive thymocytes2012
- Author(s)
  Norimasa Tamehiro
- Organizer
  日本免疫学会総会
- Place of Presentation
  神戸
- Year and Date
  2012-12-05
- Data Source
  KAKENHI-PROJECT-24790491
[Presentation] TCR-dependent proteasomal degradation of RhoH in CD4CD8 double positive thymocytes2012
- Author(s)
  Norimasa Tamehiro, Hiroyo Oda, and Harumi Suzuki
- Organizer
  日本免疫学会　総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24790491
[Presentation] RhoH欠損マウスで認められる乾癬様皮膚炎の解析
- Author(s)
  為広紀正、小田浩代、鈴木春巳
- Organizer
  第２４回 Kyoto T Cell Conference
- Place of Presentation
  京都市
- Year and Date
  2014-05-16 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25460606
[Presentation] Themis regulates cytokine production in mature naïve T cells
- Author(s)
  Toshiyuki Okada, Takeshi Nitta, Norimasa Tamehiro, Patrick Michael, Harumi Suzuki
- Organizer
  ThymOz International Conference
- Place of Presentation
  Heron Island, Queensland, Australia
- Year and Date
  2014-04-02 – 2014-04-07
- Data Source
  KAKENHI-PROJECT-25460606

1. 近藤一成 (40270623)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Nitta Takeshi (30373343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. OKADA Toshiyuki (10607328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 柴田識人 (30391973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 曽我慶介 (50746336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 宮崎幸造 (40372164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 長澤丘司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 白井睦訓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tamehiro Norimasa 為広 紀正

TAMEHIRO Norimasa 為広 紀正

Research Projects

Research Products

Co-Researchers

Development of food-allergy prediction system using large language model

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of cell-cycle-regulated CRISPR/Cas system

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

皮膚炎を自然発症するBalb/c背景Themis遺伝子欠損マウスの解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of regulatory T cells in tolerance to food allergy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research for signaling molecules that regulate mast cell-mediated allergic reactionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on nuclear signaling proteins required for T cell development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of psoriasis-like chronic dermatitis in RhoH deficient micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Models of Allergic Disease（Series: Methods in Molecular Biology）2020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Novel machine learning method allerStat identifies statistically significant allergen-specific patterns in protein sequences2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Real-time PCR Detection Methods for Food Allergens (Wheat, Buckwheat, and Peanuts) Using Reference Plasmids.2019

Author(s)

Journal Title

Data Source

[Journal Article] Ras homolog gene family H (RhoH) deficiency induces psoriasis-like chronic dermatitis by promoting TH17 cell polarization.2019

Author(s)

Journal Title

Data Source

[Journal Article] Cross-allergenicity of crustacean and the edible insect Gryllus bimaculatus in patients with shrimp allergy.2019

Author(s)

Journal Title

Data Source

[Journal Article] Determining Food Allergens by Skin Sensitization in Mice.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] T-cell activation RhoGTPase-activating protein plays an important role in TH17-cell differentiation.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LXR Agonism Upregulates the Macrophage ABCA1/Syntrophin Protein Complex That Can Bind ApoA-I and Stabilized ABCA1 Protein, but Complex Loss Does Not Inhibit Lipid Efflux.2015

Tamehiro Norimasa 為広紀正

TAMEHIRO Norimasa 為広紀正