LEE Sachiko 李佐知子

… Alternative Names

Lee Sachiko 李佐知子

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Researcher Number	80599316
Other IDs
Affiliation (Current)	2025: 名古屋大学, 医学系研究科(保健), 准教授
Affiliation (based on the past Project Information) *help	2025: 名古屋大学, 医学系研究科(保健), 准教授 2018 – 2023: 名古屋大学, 医学系研究科(保健), 准教授 2016: 名古屋大学, 医学系研究科(保健), 准教授 2015: 名古屋大学, 医学(系)研究科(研究院), 准教授 2012 – 2014: 名古屋大学, 医学(系)研究科(研究院), 助教 2012: 名古屋大学, 医学系研究科(保健), 助教 2011: 名古屋大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 59010:Rehabilitation science-related / Rehabilitation science/Welfare engineering / Rehabilitation science/Welfare engineering
Keywords	Principal Investigator 痙縮 / リハビリテーション / 脳梗塞 / KCC2 / 網様体脊髄路 / 抑制性介在神経細胞 / Ia活動抑制 / 脊髄損傷 / DHPG / EN1 … More / ptf1a / PLDーmGluR / PLD-mGluR / Ia線維 / 恒常的可塑性 / 脳活動 / 恒常的シナプス可塑性 / 恒常性シナプス可塑性 / マンガン造影MRI / MRI / MdV / 恒常的可塑的変化 / 可塑的変化 / 量的変化 / 形態変化 / アセチルコリン受容体 / 神経筋接合部 / Ia afferent fibers / stroke / spasticity / serotonin / Hoffman reflex / Cortical injury / Spasticity / 脳卒中 / 理学療法学 Less

痙縮マウスによる巧緻動作の神経回路との類似性に着眼した痙縮メカニズム解明Principal Investigator
- Principal Investigator
  
  李佐知子
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Nagoya University
Effects of Ia inhibition on spasticity after central nervous system injuryPrincipal Investigator
- Principal Investigator
  
  Lee Sachiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Nagoya University
The relationship between spasticity after stroke and homeostatic synaptic plasticity in the reticular formation.Principal Investigator
- Principal Investigator
  
  Lee Sachiko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Nagoya University
Effect of neuromuscular junction in paralysis spasticity muscle after strokePrincipal Investigator
- Principal Investigator
  
  LEE Sachiko
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Nagoya University
Mechanism of hyper activity of motoneuron and effect of rehabilitation in spasticity post-stroke mouse.Principal Investigator
- Principal Investigator
  
  LEE Sachiko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Nagoya University
Investigation of mechanism for spasticity after cortical injuryPrincipal Investigator
- Principal Investigator
  
  LEE Sachiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Nagoya University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Protective effects of hachimijiogan (HJG), a Japanese Kampo medicine, on cancer cachectic muscle wasting in mice2023
- Author(s)
  KAMETAKA Satoshi、ISOBE Mari、KOMATA Kenshin、MORINAGA Makoto、NAGAHATA Kazuma、Lee-HOTTA Sachiko、UCHIYAMA Yasushi、SHIBATA Masahiro、SUGIURA Hideshi
- Journal Title
  
  Biomed. Res.
  
  Volume: 44 Issue: 5 Pages: 199-207
- DOI
  10.2220/biomedres.44.199
- ISSN
  0388-6107, 1880-313X
- Year and Date
  2023-09-27
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11260
[Journal Article] Gait disorders induced by photothrombotic cerebellar stroke in mice.2023
- Author(s)
  Inoue K, Asaka M, Lee S, Ishikawa K, Yanagihara D.
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 15805-15805
- DOI
  10.1038/s41598-023-42817-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07432, KAKENHI-PROJECT-21K11260, KAKENHI-PROJECT-20KK0226
[Journal Article] Role of the BDNF-TrkB pathway in KCC2 regulation and rehabilitation following neuronal injury: A mini review2019
- Author(s)
  Lee-Hotta Sachiko、Uchiyama Yasushi、Kametaka Satoshi
- Journal Title
  
  Neurochemistry International
  
  Volume: 128 Pages: 32-38
- DOI
  10.1016/j.neuint.2019.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K10706
[Journal Article] Correction: Clathrin adaptor GGA1 modulates myogenesis of C2C12 myoblasts2018
- Author(s)
  Isobe Mari、Lee Sachiko、Waguri Satoshi、Kametaka Satoshi
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 12 Pages: e0209441-e0209441
- DOI
  10.1371/journal.pone.0209441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K10706
[Journal Article] Down-regulation of KCC2 expression and phosphorylation in motoneurons, and increases the number of in primary afferent projections to motoneurons in mice with post-stroke spasticity.2014
- Author(s)
  Toda T, Ishida K, Kiyama H, Yamashita T, Lee S
- Journal Title
  
  PLos One
  
  Volume: 9 Issue: 12 Pages: 1-18
- DOI
  10.1371/journal.pone.0114328
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111007, KAKENHI-PROJECT-25750201, KAKENHI-PROJECT-26350610
[Journal Article] Weakened rate-dependent depression of Hoffmann’s reflex and increased motoneuron hyperactivity after motor cortical infarction in mice2014
- Author(s)
  Lee S, TodaT, Kiyama H, and Yamashita T
- Journal Title
  
  Cell Death & Disease
  
  Volume: 5 Issue: 1 Pages: e1007-e1007
- DOI
  10.1038/cddis.2013.544
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111007, KAKENHI-PROJECT-25750201
[Journal Article] Characterizing the neurite outgrowth inhibitory effect of Mani.2012
- Author(s)
  Mishra M, Lee S, Lin MK, Yamashita T, Heese K.
- Journal Title
  
  FEBS Lett.
  
  Volume: 21 Issue: 19 Pages: 3018-23
- DOI
  10.1016/j.febslet.2012.06.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700598
[Presentation] 活動依存性マンガン造影MRIを用いた脳梗塞痙縮発症マウスにおける延髄網様体腹側核の神経活動累積の定量解析2024
- Author(s)
  李佐知子
- Organizer
  2023年度文部科学省学術変革領域研究学術研究支援基盤形成先端モデル動物支援プラットフォーム成果発表会
- Data Source
  KAKENHI-PROJECT-21K11260
[Presentation] 新たな痙縮治療法確立を目指した持続的なIa線維活動抑制による痙縮軽減効果と神経可塑的変化への影響の確認2023
- Author(s)
  花﨑拓人、花木奎太、李佐知子
- Organizer
  文部科学省　学術変革領域研究　先端モデル動物視線プラットフォーム　2023年度若手技術支援講習会
- Data Source
  KAKENHI-PROJECT-21K11260
[Presentation] 脳梗塞後の神経可塑的変化における“REST”の発現変化の確認2023
- Author(s)
  佐光幸叶、鈴木裕美香、亀髙諭、李佐知子
- Organizer
  第28回日本基礎理学療法学会学術大会
- Data Source
  KAKENHI-PROJECT-21K11260
[Presentation] 脊髄損傷後早期におけるIa線維の持続的活動抑制による神経回路の可塑的変化と痙縮軽減効果の検討2023
- Author(s)
  花﨑拓人、李佐知子
- Organizer
  第28回日本基礎理学療法学会学術大会
- Data Source
  KAKENHI-PROJECT-21K11260
[Presentation] Quantitative analysis of neuronal activity using activation induced manganese-enhanced MRI in ischemic stroke with spasticity2023
- Author(s)
  Sachiko Lee , Shogo Isumi , Hirohito Kan , Makoto Osanai
- Organizer
  The 46thAnnual Meeting of the Japan Neuroscience Society
- Data Source
  KAKENHI-PROJECT-21K11260
[Presentation] Does suppression of Ia fiber activity, which is intended to reduce spasticity caused by spinal cord injury, promote motor function recovery?2023
- Author(s)
  花木奎太、李佐知子
- Organizer
  文部科学省　学術変革領域研究　先端モデル動物視線プラットフォーム　2024年度若手技術支援講習会
- Data Source
  KAKENHI-PROJECT-21K11260
[Presentation] 脳梗塞後痙縮発症マウスにおける脊髄抑制性神経回路の形態学的変化の確認2023
- Author(s)
  宮田正太郎, 李佐知子
- Organizer
  文部科学省　学術変革領域研究　先端モデル動物視線プラットフォーム　2025年度若手技術支援講習会
- Data Source
  KAKENHI-PROJECT-21K11260
[Presentation] The relationship of expression of “REST” and neuroplastic changes after ischemic stroke2023
- Author(s)
  佐光幸叶、鈴木裕美香、亀髙諭、李佐知子
- Organizer
  文部科学省　学術変革領域研究　先端モデル動物視線プラットフォーム　2025年度若手技術支援講習会
- Data Source
  KAKENHI-PROJECT-21K11260
[Presentation] Reduction of spasticity and plastic changes in spinal neuronal circuits by suppression of neuronal activity of Ia fibers at the onset of spasticity after spinal cord injury2023
- Author(s)
  Takuto Hanasaki, Keita Hanaki, Sachiko Lee
- Organizer
  The 46th Annual Meeting of the Japan Neuroscience Society
- Data Source
  KAKENHI-PROJECT-21K11260
[Presentation] 脊髄損傷により生じる痙縮を軽減する目的で行うIa線維活動抑制は、運動機能回復を促すか。2023
- Author(s)
  花木奎太、李佐知子
- Organizer
  第28回日本基礎理学療法学会学術大会
- Data Source
  KAKENHI-PROJECT-21K11260
[Presentation] 第6頸髄半切マウスにおける、Ia線維の神経活動抑制による痙縮軽減および脊髄神経回路の可塑的変化について2022
- Author(s)
  花﨑拓人、李佐知子
- Organizer
  Neur2022
- Data Source
  KAKENHI-PROJECT-21K11260
[Presentation] 脊髄損傷により生じる痙縮を軽減する目的で行うIa線維活動抑制は、運動機能回復を促すか。2022
- Author(s)
  花木奎太、李佐知子
- Organizer
  若手支援技術講習会（先端モデル動物支援プラットフォーム総括支援活動）
- Data Source
  KAKENHI-PROJECT-21K11260
[Presentation] マンガン造影MRIを用いた脳梗塞後痙縮発症モデルマウスにおける脳神経活動の定量解析2022
- Author(s)
  伊住祥吾, 小山内実、菅博人、虫明元、李佐知子
- Organizer
  若手支援技術講習会（先端モデル動物支援プラットフォーム総括支援活動）
- Data Source
  KAKENHI-PROJECT-18K10706
[Presentation] Effects of Ia fiber activity inhibition on reduction of spasticity measured by Rate Dependent Depression of Hoffman's reflex2021
- Author(s)
  Takuto Hanasaki, Sachiko Lee-Hotta
- Organizer
  Yonsei-Nagoya University Research Exchange Meeting on Health Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K11260
[Presentation] 脳梗塞後痙縮発症マウスの皮質網様体路シナプス終末における恒常的可塑的変化2020
- Author(s)
  二村太基、花﨑拓人、李佐知子
- Organizer
  第25回日本基礎理学療法学術大会
- Data Source
  KAKENHI-PROJECT-18K10706
[Presentation] 脳梗塞後痙縮発症マウスの皮質網様体路終末に梗塞後早期から恒常的シナプス可塑性が生じる2020
- Author(s)
  二村太基、李佐知子
- Organizer
  第4回日本リハビリテーション医学会秋季学術集会
- Data Source
  KAKENHI-PROJECT-18K10706
[Presentation] 脳梗塞後痙縮を発症した骨格筋の神経筋接合部における変化2018
- Author(s)
  杉浦健司、能城裕哉、山下雄大、李佐知子
- Organizer
  第２３回日本基礎理学療法学会学術大会
- Data Source
  KAKENHI-PROJECT-18K10706
[Presentation] 脳梗塞後、脳幹網様体神経細胞にシナプスの恒常的可塑的変化が生じる2017
- Author(s)
  鹿島崇人、李佐知子
- Organizer
  第５２回日本理学療法学術大会
- Place of Presentation
  千葉
- Year and Date
  2017-05-12
- Data Source
  KAKENHI-PROJECT-15K12579
[Presentation] 脳梗塞後痙縮発症マウスの延髄網様体神経細胞における恒常的可塑的変化の可能性2016
- Author(s)
  鹿島崇人、李佐知子
- Organizer
  第３９回日本神経科学学会
- Place of Presentation
  横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K12579
[Presentation] 脳梗塞後痙縮発症マウスの延髄毛様体神経細胞の活動性変化および延髄毛様体脊髄路切断によるHoffmann反射のRate dependent depressionの再現.2015
- Author(s)
  李佐知子
- Organizer
  Neuroscience2015.
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15K12579
[Presentation] 痙縮発症マウスの延髄網様体神経核は細胞活動性が亢進延髄網様体脊髄路の遮断により痙縮は弱化する2015
- Author(s)
  李佐知子、金子葵
- Organizer
  第50回日本理学療法学術大会
- Place of Presentation
  東京
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-15K12579
[Presentation] Wheel running exercise may improve spasticity and recover the KCC2 expression levels in plasma membrane of motoneuron in spastic mice after the stroke2013
- Author(s)
  Takuya Toda, Sachiko Lee
- Organizer
  Neuro2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25750201
[Presentation] Descending fibers from cortical neurons in contralesional supplemental motor area are spouted and increased in the red nucleus, reticular nucleus, and cervical spinal cord in spastic mice after the stroke.2013
- Author(s)
  Sachiko Lee
- Organizer
  Neuro2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25750201
[Presentation] 脳卒中後痙縮出現筋の脊髄運動神経細胞膜上KCC2発現は減少する2013
- Author(s)
  戸田拓弥、李佐知子
- Organizer
  第48回日本理学療法学術大会(愛知)
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PROJECT-25750201
[Presentation] 脳卒中後痙縮出現筋の脊髄運動神経細胞膜上 KCC2 発現は減少する2013
- Author(s)
  戸田拓弥、李佐知子
- Organizer
  第48回日本理学療法学術大会
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PROJECT-23700598
[Presentation] 新規脳卒中spasticity発症マウスの確立2013
- Author(s)
  李佐知子
- Organizer
  第48回日本理学療法学術大会(愛知)
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PROJECT-25750201
[Presentation] 新規脳卒中 spasticity 発症マウスの確立2013
- Author(s)
  李佐知子
- Organizer
  第48回日本理学療法学術大会
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PROJECT-23700598
[Presentation] Interaction between down-regulation of KCC2 expression in plasma membranes of spinal motoneuron and spasticity after stroke in mice2012
- Author(s)
  Toda T. Lee S
- Organizer
  The 35th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-23700598
[Presentation] Interaction between down-regulation of KCC2 expression in plasma membranes of spinal motoneuron and spasticity after stroke in mice.2012
- Author(s)
  戸田拓弥、李佐知子
- Organizer
  The 35th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  Nagoya, Japan
- Data Source
  KAKENHI-PROJECT-23700598
[Presentation] A novel spasticity model for stroke in mice.2012
- Author(s)
  李佐知子
- Organizer
  The 35th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  Nagoya, Japan
- Data Source
  KAKENHI-PROJECT-23700598
[Presentation] Interaction between down-regulation of KCC2 expression in plasma membranes of spinal motoneuron and spasticity after stroke in mice2012
- Author(s)
  Takuya Toda, Sachiko Lee
- Organizer
  Nagoya-Yonsei University Research Exchange Meeting on Health Sciences 2012
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-23700598
[Presentation] A novel spasticity model for stroke in mice2012
- Author(s)
  Lee S
- Organizer
  The 35th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-23700598
[Presentation] A novel spasticity model for cerebral cortex injury in mice.2012
- Author(s)
  李佐知子
- Organizer
  8th FENS Forum of Neuroscience
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-23700598
[Presentation] A novel spasticity model for cerebral cortex injury in mice2012
- Author(s)
  Lee S
- Organizer
  8th FENS Forum of Neuroscience
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-23700598
[Presentation] 理学療法士女性研究者の現状と今後の発展－多様なロールモデル－」　　　女性を取り巻く現状－キャリア形成を目指して－
- Author(s)
  李佐知子
- Organizer
  第1 回日本基礎理学療法学会学術集会・日本基礎理学療法学会第4 回学術大　　　会合同学会
- Place of Presentation
  名古屋
- Year and Date
  2014-11-15 – 2014-11-16
- Invited
- Data Source
  KAKENHI-PROJECT-25750201
[Presentation] Development of animal model of post-stroke spasticity and study of its mechanisms.
- Author(s)
  李佐知子
- Organizer
  CREST合同成果報告会
- Place of Presentation
  犬山、京都大学霊長類研究所
- Year and Date
  2014-09-26 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25750201
[Presentation] 脳梗塞後痙縮発症マウスの延髄網様体脊髄路切断によるHoffmann反射Rate dependent depressionの再現
- Author(s)
  李佐知子
- Organizer
  第1 回日本基礎理学療法学会学術集会・日本基礎理学療法学会第4 回学術大会合同学会
- Place of Presentation
  名古屋
- Year and Date
  2014-11-15 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-25750201
[Presentation] 痙縮発症マウスの延髄網様体神経核は細胞活動性が亢進する
- Author(s)
  金子葵、李佐知子
- Organizer
  第1 回日本基礎理学療法学会学術集会・日本基礎理学療法学会第4 回学術大会合同学会
- Place of Presentation
  名古屋
- Year and Date
  2014-11-15 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-25750201

1. 亀高諭 (10303950)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 石川欽也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 柳原大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 木山博資

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

LEE Sachiko 李 佐知子

Lee Sachiko 李 佐知子

Research Projects

Research Products

Co-Researchers

痙縮マウスによる巧緻動作の神経回路との類似性に着眼した痙縮メカニズム解明Principal Investigator

Principal Investigator

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Research Institution

Effects of Ia inhibition on spasticity after central nervous system injuryPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

The relationship between spasticity after stroke and homeostatic synaptic plasticity in the reticular formation.Principal Investigator

Principal Investigator

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Review Section

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Effect of neuromuscular junction in paralysis spasticity muscle after strokePrincipal Investigator

Principal Investigator

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Research Institution

Mechanism of hyper activity of motoneuron and effect of rehabilitation in spasticity post-stroke mouse.Principal Investigator

Principal Investigator

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Research Institution

Investigation of mechanism for spasticity after cortical injuryPrincipal Investigator

Principal Investigator

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Research Institution

[Journal Article] Protective effects of hachimijiogan (HJG), a Japanese Kampo medicine, on cancer cachectic muscle wasting in mice2023

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[Journal Article] Gait disorders induced by photothrombotic cerebellar stroke in mice.2023

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[Journal Article] Role of the BDNF-TrkB pathway in KCC2 regulation and rehabilitation following neuronal injury: A mini review2019

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[Journal Article] Correction: Clathrin adaptor GGA1 modulates myogenesis of C2C12 myoblasts2018

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[Journal Article] Down-regulation of KCC2 expression and phosphorylation in motoneurons, and increases the number of in primary afferent projections to motoneurons in mice with post-stroke spasticity.2014

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[Journal Article] Weakened rate-dependent depression of Hoffmann’s reflex and increased motoneuron hyperactivity after motor cortical infarction in mice2014

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[Journal Article] Characterizing the neurite outgrowth inhibitory effect of Mani.2012

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[Presentation] 活動依存性マンガン造影MRIを用いた脳梗塞痙縮発症マウスにおける延髄網様体腹側核の神経活動累積の定量解析2024

LEE Sachiko 李佐知子

Lee Sachiko 李佐知子