Hori Yukiko 堀由起子

Researcher Number	80610683
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院薬学系研究科(薬学部), 准教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 東京大学, 大学院薬学系研究科(薬学部), 准教授 2019 – 2020: 東京大学, 大学院薬学系研究科(薬学部), 講師 2016 – 2018: 東京大学, 大学院薬学系研究科(薬学部), 助教 2014 – 2015: 東京大学, 薬学研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Biological pharmacy / Transformative Research Areas, Section (II) Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Transformative Research Areas, Section (II)
Keywords	Principal Investigator 神経科学 / 脳神経疾患 / アルツハイマー病 / 神経変性疾患 Except Principal Investigator 認知症 / 細胞連関 / アミロイド / ストレス応答 / グリア細胞 / 神経変性 … More / タンパク分解 / オートファジー / 機能連関 / 脳内ホメオスタシス / タンパク質間相互作用 / 酵素活性 / 神経炎症 / 脳ホメオスタシス / タンパク質操作 / アプタマー Less

非細胞自律的酸素化アミロイド除去機構の解明Principal Investigator
- Principal Investigator
  
  堀由起子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  The University of Tokyo
中枢神経系プロテイノパチー発症機構の統合的解明
- Principal Investigator
  
  富田泰輔
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Elucidation of the role of autophagy in photo-oxygenated amyloid degradation
- Principal Investigator
  
  富田泰輔
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
アプタマー生物学の創成による脳内恒常性維持機構の解明
- Principal Investigator
  
  塚越かおり
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Tokyo University of Agriculture and Technology
アプタマー生物学による脳内Aβホメオスタシス機構の意義の解明Principal Investigator
- Principal Investigator
  
  堀由起子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
人工的酸素付加によるアミロイド動態制御機構の解明Principal Investigator
- Principal Investigator
  
  堀由起子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  The University of Tokyo
Elucidation of Cellular Pathogenesis as a Key Mechanism for Neurodegenerative Processes in the Pathogenesis of Dementia
- Principal Investigator
  
  Tomita Taisuke
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
The analysis of clearance mechanism of oxygenated AbetaPrincipal Investigator
- Principal Investigator
  
  Hori Yukiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  The University of Tokyo
Genome wide screening of genes involved in Abeta phagocytosis by CRISPR/Cas9 systemPrincipal Investigator
- Principal Investigator
  
  Hori Yukiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
The functional role of Eph/ephrin signal as neuron-glia communication in the regulation of brain Abeta levelPrincipal Investigator
- Principal Investigator
  
  Hori Yukiko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Book Other

[Book] Geriatric Medicine（老年医学）2020
- Author(s)
  堀由起子、富田泰輔
- Total Pages
  5
- Publisher
  ライフ・サイエンス
- Data Source
  KAKENHI-PROJECT-19H01015
[Journal Article] Protocol for gene knockdown using siRNA in primary cultured neonatal murine microglia2024
- Author(s)
  Kato Yuma、Takatori Sho、Akahori Aika、Etani Hayato、Chu Yung Ning、Tomita Taisuke
- Journal Title
  
  STAR Protocols
  
  Volume: 5 Issue: 1 Pages: 102867-102867
- DOI
  10.1016/j.xpro.2024.102867
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07344, KAKENHI-PROJECT-23H00394
[Journal Article] Identification of novel regulators involved in AD pathogenesis using the CRISPR-Cas9 system2023
- Author(s)
  Tomizawa I, Chiu YW, Hori Y, Tomita T
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 158 Issue: 1 Pages: 21-25
- DOI
  10.1254/fpj.22081
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22H05036, KAKENHI-PROJECT-23H00394
[Journal Article] Rose Bengal Promoted Catalytic Amyloid-β Oxygenation by Sonoactivation2023
- Author(s)
  Sohma Youhei、Hori Yukiko、Tomita Taisuke、Kanai Motomu、Atsumi Wataru、Kawabata Keiichi、Yamane Mina、Oi Miku、Mitsunuma Harunobu
- Journal Title
  
  Synlett
  
  Volume: 35 Issue: 08 Pages: 920-924
- DOI
  10.1055/a-2182-7614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06045, KAKENHI-PROJECT-21H02602, KAKENHI-PROJECT-23K21357
[Journal Article] Quantitative Assays for Catalytic Photo-Oxygenation of Alzheimer Disease-Related Tau Proteins2023
- Author(s)
  Umeda Hiroki、Sawazaki Taka、Furuta Masahiro、Suzuki Takanobu、Kawashima Shigehiro A.、Mitsunuma Harunobu、Hori Yukiko、Tomita Taisuke、Sohma Youhei、Kanai Motomu
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 14 Issue: 15 Pages: 2710-2716
- DOI
  10.1021/acschemneuro.3c00264
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KK0133, KAKENHI-PROJECT-21K15220, KAKENHI-PLANNED-20H05843, KAKENHI-PROJECT-23H00394, KAKENHI-PROJECT-21H02602, KAKENHI-PROJECT-23K21357
[Journal Article] Photo‐oxygenation of histidine residue inhibits α‐synuclein aggregation2023
- Author(s)
  Nakamura Reito、Tomizawa Ikumi、Iwai Atsushi、Ikeda Tetsuo、Hirayama Kota、Chiu Yung Wen、Suzuki Takanobu、Tarutani Airi、Mano Tatsuo、Iwata Atsushi、Toda Tatsushi、Sohma Youhei、Kanai Motomu、Hori Yukiko、Tomita Taisuke
- Journal Title
  
  The FASEB Journal
  
  Volume: 37 Issue: 12
- DOI
  10.1096/fj.202301533r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KK0133, KAKENHI-PROJECT-22K07512, KAKENHI-ORGANIZER-22H05035, KAKENHI-PROJECT-23H00394, KAKENHI-PROJECT-20H03587, KAKENHI-PROJECT-21H02602, KAKENHI-PROJECT-23K21357
[Journal Article] Attenuation of α-synuclein aggregation by catalytic photo-oxygenation2023
- Author(s)
  Iwai Atsushi、Nakamura Reito、Tomizawa Ikumi、Mitsunuma Harunobu、Hori Yukiko、Tomita Taisuke、Sohma Youhei、Kanai Motomu
- Journal Title
  
  Chemical Communications
  
  Volume: 59 Issue: 38 Pages: 5745-5748
- DOI
  10.1039/d3cc00665d
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KK0133, KAKENHI-PROJECT-23H00394, KAKENHI-PROJECT-21H02602, KAKENHI-PROJECT-23K21357
[Journal Article] Pathological Roles of INPP5D in Alzheimer’s Disease2023
- Author(s)
  Chu Yung Ning、Akahori Aika、Takatori Sho、Tomita Taisuke
- Journal Title
  
  Advances in Experimental Medicine and Biology
  
  Volume: 1423 Pages: 289-301
- DOI
  10.1007/978-3-031-31978-5_30
- ISBN
  9783031319778, 9783031319785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07344, KAKENHI-PROJECT-23H00394
[Journal Article] Photo-Oxygenation as a New Therapeutic Strategy for Neurodegenerative Proteinopathies by Enhancing the Clearance of Amyloid Proteins2022
- Author(s)
  Tomizawa Ikumi、Nakagawa Hanako、Sohma Youhei、Kanai Motomu、Hori Yukiko、Tomita Taisuke
- Journal Title
  
  Frontiers in Aging Neuroscience
  
  Volume: 14
- DOI
  10.3389/fnagi.2022.945017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-23K21357, KAKENHI-PROJECT-21H02602
[Journal Article] Promotion in the Clearance of Aggregated Aβ In Vivo Using Amyloid Selective Photo-Oxygenation Technology2022
- Author(s)
  Hori Yukiko、Sohma Youhei、Kanai Motomu、Tomita Taisuke
- Journal Title
  
  Neuroscience Insights
  
  Volume: 17 Pages: 0000-0000
- DOI
  10.1177/26331055221126179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-23K21357, KAKENHI-PROJECT-20H00489, KAKENHI-PROJECT-21H02602
[Journal Article] A red fluorescent genetically encoded biosensor for extracellular L-lactate2022
- Author(s)
  Nasu Yusuke、Kamijo Yuki、Hashizume Rina、Sato Haruaki、Hori Yukiko、Tomita Taisuke、Drobizhev Mikhail、Campbell Robert E.
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2022.08.30.505811
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-22KJ0968, KAKENHI-PROJECT-21K14738
[Journal Article] タウ免疫療法の現状2021
- Author(s)
  富田泰輔、堀由起子
- Journal Title
  
  Geriatric Medicine（老年医学）
  
  Volume: 59 Pages: 185-189
- Data Source
  KAKENHI-PROJECT-19H01015
[Journal Article] Catalytic photooxygenation degrades brain Aβ in vivo2021
- Author(s)
  Nagashima Nozomu、Ozawa Shuta、Furuta Masahiro、Oi Miku、Hori Yukiko、Tomita Taisuke、Sohma Youhei、Kanai Motomu
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 13 Pages: 0-1
- DOI
  10.1126/sciadv.abc9750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-19J14873, KAKENHI-PROJECT-20J22142, KAKENHI-PROJECT-18K06653, KAKENHI-PROJECT-19K22484, KAKENHI-PROJECT-20H00489
[Journal Article] Photo-oxygenation: an innovative new therapeutic approach against amyloidoses2021
- Author(s)
  Ikeda T, Hori Y, Sohma Y, Kanai M, and Tomita T
- Journal Title
  
  Adv Exp Med Biol.
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06653
[Journal Article] Photo-Oxygenation: An Innovative New Therapeutic Approach Against Amyloidoses2021
- Author(s)
  Ikeda Tetsuo、Hori Yukiko、Sohma Youhei、Kanai Motomu、Tomita Taisuke
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 1 Pages: 415-422
- DOI
  10.1007/978-3-030-78787-5_52
- ISBN
  9783030787868, 9783030787875
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-23K21357
[Journal Article] GPR120 signaling controls amyloid-β degrading activity of matrix metalloproteinases2021
- Author(s)
  Kazunori Kikuchi, Takuya Tatebe, Yuki Sudo, Miyabishara Yokoyama, Kiwami Kidana, Yung Wen Chiu, Sho Takatori, Makoto Arita, Yukiko Hori, Taisuke Tomita
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 41(28) Issue: 28 Pages: 6173-6185
- DOI
  10.1523/jneurosci.2595-20.2021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07080, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-20H00495, KAKENHI-PROJECT-23K21357
[Journal Article] Photo-oxygenation by a biocompatible catalyst reduces amyloid-β levels in the brains of Alzheimer’s disease model mice2021
- Author(s)
  Ozawa S, Hori Y, Shimizu Y, Taniguchi A, Suzuki T, Wang W, Chiu YW, Koike R, Yokoshima S, Fukuyama T, Takatori S, Sohma Y, Kanai M, Tomita T
- Journal Title
  
  Brain
  
  Volume: - Issue: 6 Pages: 1884-1897
- DOI
  10.1093/brain/awab058
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06653, KAKENHI-PROJECT-19K07001, KAKENHI-PROJECT-19K07080, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-20H00489
[Journal Article] Peptide-based short single β-strand mimics without hydrogen bonding or aggregation2020
- Author(s)
  Zhai Luhan、Otani Yuko、Hori Yukiko、Tomita Taisuke、Ohwada Tomohiko
- Journal Title
  
  Chemical Communications
  
  Volume: 56 Issue: 10 Pages: 1573-1576
- DOI
  10.1039/c9cc08378b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-18H02552
[Journal Article] EphA4 regulates Aβ production via BACE1 expression in neurons2020
- Author(s)
  Tamura Kensuke、Chiu Yung‐Wen、Shiohara Azusa、Hori Yukiko、Tomita Taisuke
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 12 Pages: 16383-16396
- DOI
  10.1096/fj.202001510r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-18K06653
[Journal Article] Identification of calcium and integrin‐binding protein 1 as a novel regulator of production of amyloid β peptide using CRISPR/Cas9‐based screening system2020
- Author(s)
  Chiu Yung Wen、Hori Yukiko、Ebinuma Ihori、Sato Haruaki、Hara Norikazu、Ikeuchi Takeshi、Tomita Taisuke
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 6 Pages: 7661-7674
- DOI
  10.1096/fj.201902966rr
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01015
[Journal Article] Photo-oxygenation inhibits tau amyloid formation2019
- Author(s)
  Suzuki T*, Hori Y*, Sawazaki T, Shimizu Y, Nemoto Y, Taniguchi A, Ozawa S, Sohma Y, Kanai M, Tomita T
- Journal Title
  
  Chem. Commun.
  
  Volume: 55(44) Issue: 44 Pages: 6165-6168
- DOI
  10.1039/c9cc01728c
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06653, KAKENHI-PROJECT-19K07001, KAKENHI-PROJECT-19K22484, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-19J14873, KAKENHI-PROJECT-19J23179, KAKENHI-PROJECT-17K19479, KAKENHI-PROJECT-17H01522, KAKENHI-PROJECT-16H06216
[Journal Article] CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway2019
- Author(s)
  Furusawa K, Takasugi T, Chiu YW, Hori Y, Tomita T, Fukuda M, Hisanaga SI
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 294(28) Issue: 28 Pages: 10886-10899
- DOI
  10.1074/jbc.ra118.005385
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06653, KAKENHI-PROJECT-19K06942, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-18J01378
[Journal Article] Retrograde transport of γ-secretase from endosomes to the trans-Golgi network regulates Aβ42 production.2018
- Author(s)
  Kanatsu K, Hori Y, Ebinuma I, Chiu YW, Tomita T
- Journal Title
  
  J. Neurochem.
  
  Volume: 147(1) Issue: 1 Pages: 110-123
- DOI
  10.1111/jnc.14477
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06653, KAKENHI-PROJECT-15H02492
[Journal Article] Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer’s disease model mice2018
- Author(s)
  Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: 10 Issue: 3
- DOI
  10.15252/emmm.201708184
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15446, KAKENHI-PROJECT-15H02492, KAKENHI-PROJECT-15H04800, KAKENHI-PROJECT-16K18871
[Journal Article] Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide2018
- Author(s)
  Ni J, Taniguchi A, Ozawa S, Hori Y, Kuninobu Y, Saito T, Saido TC, Tomita T, Sohma Y, Kanai M
- Journal Title
  
  Chem
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18871
[Journal Article] A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease.2015
- Author(s)
  Hori Y, Takeda S, Cho H, Wegmann S, Shoup TM, Takahashi K, Irimia D, Elmaleh DR, Hyman BT, Hudry E.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 290 Issue: 4 Pages: 1966-1978
- DOI
  10.1074/jbc.m114.586602
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26893042
[Journal Article] Role of apolipoprotein E in β-amyloidgenesis: isoform-specific effects on protofibril to fibril conversion of Aβ in vitro and brain Aβ deposition in vivo.2015
- Author(s)
  Yukiko Hori, Tadafumi Hashimoto, Hidetoshi Nomoto, Bradley T Hyman, Takeshi Iwatsubo
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 290 Issue: 24 Pages: 15163-15174
- DOI
  10.1074/jbc.m114.622209
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-26893042
[Presentation] Non-invasive photo-oxygenation reduces intracellular tau amyloid in the brain of tau model mice.2024
- Author(s)
  Yukiko Hori, Takanobu Suzuki, Taka Sawazaki, Makoto Higuchi, Youhei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  AD/PD2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] Non-invasive photo-oxygenation reduces intracellular tau amyloid in the brain of tau model mice.2024
- Author(s)
  Yukiko Hori, Takanobu Suzuki, Taka Sawazaki, Makoto Higuchi, Youhei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  AD/PD2024
- Invited
- Data Source
  KAKENHI-PROJECT-23KK0133
[Presentation] 光酸素化触媒による凝集タウ除去機構の解析2023
- Author(s)
  中川葉奈子、鈴木崇允、澤崎鷹、原範和、宮下哲典、池内健、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23KK0133
[Presentation] Identification of novel regulators of structure-specific α-synuclein aggregation by genome wide screening using the CRISPR/Cas9 system2023
- Author(s)
  Ikumi Tomizawa, Yung-Wen Chiu, Tatsuo Mano, Maiko Ono, Makoto Higuchi, Tatsuo Toda, Atsushi Iwata, Yukiko Hori, Taisuke Tomita
- Organizer
  Neuroscience 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] 細胞内凝集タウに対する光酸素化の薬効の評価2023
- Author(s)
  栗山摩衣、鈴木崇允、澤崎鷹、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  第46回日本神経組織培養研究会
- Data Source
  KAKENHI-PROJECT-23KK0133
[Presentation] アルツハイマー病におけるAβ・タウ蓄積を模倣した新規マウスモデルの確立と遺伝学的危険因子への介入研究2023
- Author(s)
  赤堀愛果、高鳥翔、富田泰輔
- Organizer
  タウ研究会
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] Transcriptional regulation of KLK7, an astrocyte-derived Aβ degrading protease, in the pathogenesis of Alzheimer disease2023
- Author(s)
  Chia-Jen Sung, Yuki Sudo, Yukiko Hori. Taisuke Tomita
- Organizer
  第 22 回東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PLANNED-22H05036
[Presentation] dentification of novel regulators of structure-specific α-synuclein aggregation by genome wide screening using the CRISPR/Cas9 system.2023
- Author(s)
  Ikumi Tomizawa, Yung-Wen Chiu, Tatsuo Mano, Maiko Ono, Makoto Higuchi, Tatsuo Toda, Atsushi Iwata, Yukiko Hori, Taisuke Tomita
- Organizer
  Young researdher presentation at Mayo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] CRISPR/Cas9システムを用いた新規タウ凝集関連因子の探索2023
- Author(s)
  内藤玄、海老沼五百理、Chiu Yung-Wen、小野麻衣子、樋口真人、堀由起子、富田泰輔
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-22H05036
[Presentation] 光酸素化触媒による凝集タウ除去機構の解析2023
- Author(s)
  中川葉奈子、鈴木崇允、澤崎鷹、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  2023年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-23KK0133
[Presentation] 細胞内凝集タウに対する光酸素化の薬効の評価2023
- Author(s)
  栗山摩衣、鈴木崇允、澤崎鷹、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  2023年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] AAアミロイドーシス治療を目指した光酸素化法の検証2023
- Author(s)
  堀由起子、浅井秀一郎、渡邊謙一、相馬洋平、金井求、富田泰輔
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23KK0133
[Presentation] 光酸素化触媒による凝集タウ除去機構の解析2023
- Author(s)
  中川葉奈子、鈴木崇允、澤崎鷹、原範和、宮下哲典、池内健、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K21357
[Presentation] 細胞内温度勾配によるTDP-43凝縮体形成機構の解析2023
- Author(s)
  山根大典、寳田雅治、岡部弘基、須藤優喜、船津高志、堀由起子、富田泰輔
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] CRISPR/Cas9システムを用いた新規タウ凝集関連因子の探索2023
- Author(s)
  内藤玄、海老沼五百理、邱詠文、小野麻衣子、樋口真人、堀由起子、富田泰輔
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] 細胞内凝集タウに対する光酸素化の薬効評価2023
- Author(s)
  栗山摩衣、鈴木崇允、澤崎鷹、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  第46回神経組織培養研究会
- Data Source
  KAKENHI-PROJECT-23K21357
[Presentation] 光酸素化触媒による凝集タウ除去機構の解析2023
- Author(s)
  中川葉奈子、鈴木崇允、澤崎鷹、原範和、宮下哲典、池内健、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] 細胞内凝集タウに対する光酸素化の薬効の評価2023
- Author(s)
  栗山摩衣、鈴木崇允、澤崎鷹、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  第42回日本認知症学会
- Data Source
  KAKENHI-PROJECT-23K21357
[Presentation] 細胞内凝集タウに対する光酸素化の薬効の評価2023
- Author(s)
  栗山摩衣、鈴木崇允、澤崎鷹、相馬洋平、金井求、堀由起子、富田泰輔：
- Organizer
  2023年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-23KK0133
[Presentation] Screening for the regulators of tau secretion.2023
- Author(s)
  Haruaki Sato, Kensaku Kasuga, Noriko Isoo, Toshihiro Hayashi, Yukiko Hori, Takeshi Ikeuchi, Taisuke Tomita
- Organizer
  Neuroscience 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] AAアミロイドーシス治療を目指した光酸素化法の検証2023
- Author(s)
  浅井秀一朗、渡邊謙一、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  第10回日本アミロイドーシス学会
- Data Source
  KAKENHI-PROJECT-23K21357
[Presentation] タウオパチー治療を志向した非侵襲的光酸素化法の開発2023
- Author(s)
  堀由起子、相馬洋平、樋口真人、金井求、富田泰輔
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] CRISPR/Cas9システムを用いた新規タウ凝集関連因子の探索2023
- Author(s)
  内藤玄、海老沼五百理、Chiu Yung Wen、小野麻衣子、樋口真人、堀由起子、富田泰輔
- Organizer
  2023年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] 細胞内凝集タウに対する光酸素化の薬効の評価2023
- Author(s)
  栗山摩衣、鈴木崇允、澤崎鷹、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] タウオパチー治療を志向した非侵襲的光酸素化法の開発2023
- Author(s)
  堀由起子、相馬洋平、樋口真人、金井求、富田泰輔
- Organizer
  第96回日本生化学大会
- Invited
- Data Source
  KAKENHI-PROJECT-23KK0133
[Presentation] AAアミロイドーシス治療を目指した光酸素化法の検証2023
- Author(s)
  堀由起子、浅井秀一郎、渡邊謙一、相馬洋平、金井求、富田泰輔
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] タウタンパク質の凝集への塩添加効果2023
- Author(s)
  高橋知未、山根大典、巽理紗、堀由起子、富田泰輔、栗田玲
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23KK0133
[Presentation] 細胞内凝集タウに対する光酸素化の薬効の評価2023
- Author(s)
  栗山摩衣、鈴木崇允、澤崎鷹、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23KK0133
[Presentation] タウタンパク質の凝集への塩添加効果2023
- Author(s)
  高橋知未、山根大典、巽理紗、堀由起子、富田泰輔、栗田玲
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] Characterization of tau-containing exosomes derived from Neuro2a cells.2023
- Author(s)
  Noriko Isoo, Kentaro Kawata, Hironori Takagi, Naoyuki Iso-o, Yukiko Hori, Taisuke Tomita,
- Organizer
  Neuroscience 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] タウオパチー治療を志向した非侵襲的光酸素化法の開発2023
- Author(s)
  堀由起子、相馬洋平、樋口真人、金井求、富田泰輔
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23KK0133
[Presentation] AAアミロイドーシス治療を目指した光酸素化法の検証2023
- Author(s)
  浅井秀一郎、渡邊謙一、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  第10回アミロイドーシス学会学術集会
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] Screening for the regulators of tau secretion2023
- Author(s)
  Sato H, Kasuga K, Isoo N, Hayashi T, Ikeuchi T, Hori Y, Tomita T
- Organizer
  Society for Neuroscience 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05036
[Presentation] 細胞内凝集タウに対する光酸素化の薬効の評価2023
- Author(s)
  栗山摩衣、鈴木崇允、澤崎鷹、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  第46回日本神経組織培養研究会
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] Aβ分解酵素KLK7の発現制御機構の解明2023
- Author(s)
  堀由起子
- Organizer
  日本化学会秋季事業第13回 CSJ化学フェスタ2023
- Data Source
  KAKENHI-ORGANIZER-22H05035
[Presentation] Elucidating the Pathological Roles of INPP5D in Alzheimer Disease.2023
- Author(s)
  Sho Takatori, Akihiro Iguchi, Genta Ito, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita
- Organizer
  Neuroscience 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] Soluble form of the APP fragment, sAPPβ, positively regulates tau secretion2023
- Author(s)
  佐藤玄謙、春日健作、磯尾紀子、林俊宏、堀由起子、池内健、富田泰輔
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] Identification of novel regulators of disease-specific α-synuclein aggregation by genome wide screening using the CRISPR/Cas9 system2023
- Author(s)
  Tomizawa I, Chiu YW, Mano T, Ono M, Higuchi M, Toda T, Iwata A, Hori Y, Tomita T
- Organizer
  Society for Neuroscience 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05036
[Presentation] タウオパチー治療を志向した非侵襲的光酸素化法の開発2023
- Author(s)
  堀由起子、相馬洋平、樋口真人、金井求、富田泰輔
- Organizer
  第96回日本生化学大会
- Invited
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] Identification of the disease specific regulators of α-synuclein aggregation2023
- Author(s)
  富澤郁美、邱詠文、間野達雄、小野麻衣子、樋口真人、戸田達史、岩田淳、堀由起子、富田泰輔
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] 酸素化触媒による凝集タウ除去機構の解析2023
- Author(s)
  中川葉奈子、鈴木崇允、澤崎鷹、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  2023年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] AAアミロイドーシス治療を目指した光酸素化法の検証2023
- Author(s)
  浅井秀一朗、渡邊謙一、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  2023年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-23H00394
[Presentation] Inhibition of NF-κB pathway in the astrocytes facilitates the proteolytic clearance of amyloid-β by kallikrein-related peptidase 72022
- Author(s)
  Taisuke Tomita, Yuki Sudo, Kazunori Kikuchi, Chia Jen Sung, Sho Takatori, Yukiko Hori
- Organizer
  Society for neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05036
[Presentation] Elucidation of pathological roles of INPP5D in Alzheimer disease2022
- Author(s)
  高鳥翔、井口明優、木村新伍、堀由起子、佐々木純子、斉藤貴志、西道隆臣、池津庸哉、高井俊行、佐々木雄彦、富田泰輔
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] NF-κB経路を介したKLK7発現制御機構の解明2022
- Author(s)
  堀由起子
- Organizer
  第41回日本認知症学会
- Invited
- Data Source
  KAKENHI-PLANNED-22H05036
[Presentation] in vivo光酸素化によるタウ蓄積病理への影響の解析2022
- Author(s)
  鈴木崇允、堀由起子、相馬洋平、金井求、富田泰輔
- Organizer
  タウ研究会2022
- Data Source
  KAKENHI-PROJECT-23K21357
[Presentation] Establishment of non-invasive Aβ photooxygenation using a novel photocatalyst2022
- Author(s)
  Yukiko Hori, Nozomu Nagashima, Yohei Sohma, Motomu Kanai, Taisuke
- Organizer
  Neuroscience 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 光酸素化触媒を用いた新規AD治療戦略の開発2022
- Author(s)
  堀由起子、相馬洋平、金井求、富田泰輔
- Organizer
  第95回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] APP依存的な新規タウ分泌現象の発見2022
- Author(s)
  佐藤玄謙、春日健作、磯尾紀子、林俊宏、堀由起子、池内健、富田泰輔
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] シヌクレイノパチー治療を目指したα-シヌクレインに対する光酸素化2022
- Author(s)
  中村麗人、堀由起子、富澤郁美、池田哲生、平山皓太、岩井篤志、相馬洋平、金井求、富田泰輔
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Inhibition of NF-κB pathway in the astrocytes facilitates the proteolytic clearance of amyloid-β by kallikrein-related peptidase 72022
- Author(s)
  Taisuke Tomita, Yuki Sudo, Kazunori Kikuchi, Chia Jen Sung, Sho Takatori, Yukiko Hori
- Organizer
  Neuroscience 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 酸素化Aβ分解プロテアーゼの性状解析2022
- Author(s)
  池田哲生、堀由起子、相馬洋平、金井求、富田泰輔
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 非侵襲的光酸素化による脳内タウアミロイドの除去2022
- Author(s)
  堀由起子、鈴木崇允、澤崎鷹、樋口真人、相馬洋平、金井求、富田泰輔
- Organizer
  第41回日本認知症学会
- Data Source
  KAKENHI-PROJECT-23K21357
[Presentation] 非侵襲的光酸素化による脳内タウアミロイドの除去2022
- Author(s)
  堀由起子、鈴木崇允、澤崎鷹、高橋真奈美、田桑弘之、水島昇、樋口真人、相馬洋平、金井求、富田泰輔
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 酸素化Aβ分解プロテアーゼの性状解析2022
- Author(s)
  池田哲生、堀由起子、相馬洋平、金井求、富田泰輔
- Organizer
  2022年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-23K21357
[Presentation] Pathological roles of microglial gene INPP5D in a mouse model of Alzheimer disease.2022
- Author(s)
  Sho Takatori, Akihiro Iguchi, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita
- Organizer
  ISMND2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Establishment of non-invasive Aβ photooxygenation using a novel photocatalyst2022
- Author(s)
  Yukiko Hori, Nozomu Nagashima, Youhei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  society for neuroscience 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21357
[Presentation] Development of photooxygenation technology towards therapeutic strategy against Alzheimer disease2022
- Author(s)
  Yukiko Hori
- Organizer
  The 95th Annual Meeting of the Japanese Pharmacological Society
- Invited
- Data Source
  KAKENHI-PROJECT-23K21357
[Presentation] Discovery of a novel APP-dependent tau secretion.2022
- Author(s)
  Haruaki Sato, Yukiko Hori, Kensaku Kasuga, Noriko Isoo, Toshihiro Hayashi, Takeshi Ikeuchi, Taisuke Tomita
- Organizer
  第21回東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PLANNED-22H05036
[Presentation] 細胞内温度勾配によるTDP-43凝縮体形成機構の解析2022
- Author(s)
  山根大典、寳田雅治、岡部弘基、須藤優喜、船津高志、堀由起子、富田泰輔
- Organizer
  第44回神経組織培養研究会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 酸素化Aβ分解プロテアーゼの性状解析2022
- Author(s)
  池田哲生、堀由起子、相馬洋平、金井求、富田泰輔
- Organizer
  第41回日本認知症学会
- Data Source
  KAKENHI-PROJECT-23K21357
[Presentation] INPP5D modulates TREM2 loss-of-function phenotypes in a mouse model of Alzheimer disease.2022
- Author(s)
  Akihiro Iguchi, Sho Takatori, Shingo Kimura, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita
- Organizer
  CINF2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 光酸素化触媒を用いた新規アルツハイマー病治療戦略の開発2022
- Author(s)
  堀由起子
- Organizer
  バイオソフトマターメディカル研究会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21357
[Presentation] シヌクレイノパチー治療を目指したα-シヌクレインに対する光酸素化2022
- Author(s)
  中村麗人、堀由起子、富澤郁美、池田哲生、平山皓太、岩井篤志、相馬洋平、金井求、富田泰輔
- Organizer
  第41回日本認知症学会
- Data Source
  KAKENHI-PROJECT-23K21357
[Presentation] Photooxygenation as a new therapeutic strategy against Alzheimer's disease2022
- Author(s)
  Yukiko Hori
- Organizer
  Neuro2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21357
[Presentation] NF-κB経路を介したKLK7発現制御機構の解明2022
- Author(s)
  堀由起子, 須藤優喜, 宋家禎, 富田泰輔
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-ORGANIZER-22H05035
[Presentation] APP依存的な新規タウ分泌減少の発見2022
- Author(s)
  Haruaki Sato, Kensaku Kasuga, Noriko Isoo, Toshihiro Hayashi, Yukiko Hori Takeshi Ikeuchi, Taisuke Tomita
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PLANNED-22H05036
[Presentation] INPP5D haplodeficiency rescued TREM2-loss-of-function phenotype of microglia in Alzheimer disease model mice.2021
- Author(s)
  Akihiro Iguchi, Sho Takatori, Shingo Kimura, Yukiko Hori, Junko Sasaki, Takashi Saito, Sakaomi C. Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita
- Organizer
  New Horizons in Alzheimer's Disease (Hybrid edition)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 光酸素化反応によるミクログリアを介したアミロイド除去2021
- Author(s)
  堀由起子
- Organizer
  第40回日本認知症学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21357
[Presentation] Photo-oxygenation inhibits tau aggregation via loss of seeding activity2021
- Author(s)
  Takanobu Suzuki, Yukiko Hori, Taka Sawazaki, Yu Nemoto, Youhei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  VIB conference: New Horizons in Alzheimer's Disease (Hybrid edition)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21357
[Presentation] アストロサイト由来Aβ分解酵素Kallikrein-related peptidase 7はNMDA受容体及びNF-κB経路によって発現が制御される2021
- Author(s)
  須藤優喜、木棚究、建部卓也、菊池一徳、堀由起子、高鳥翔、富田泰輔
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病遺伝学的リスク因子BIN1がタウ蓄積病理および伝播に及ぼす影響の解析2021
- Author(s)
  根本　侑、鴇巣　正樹、堀　由起子、富田　泰輔
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-23K21357
[Presentation] アルツハイマー病遺伝学的リスク因子BIN1がタウ蓄積病理および伝播に及ぼす影響の解析2021
- Author(s)
  根本侑、鴇巣正樹、堀由起子、富田泰輔
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Photo-oxygenation inhibits tau aggregation and seeding activity.2021
- Author(s)
  Takanobu Suzuki, Yukiko Hori, Taka Sawazaki, Yu Nemoto, Yohei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  New Horizons in Alzheimer's Disease (Hybrid edition)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Photo-oxygenation by biocompatible catalyst reduced the Aβ level in the brains of Alzheimer disease model mice.2021
- Author(s)
  Taisuke Tomita, Shuta Ozawa, Nozomu Nagashima, Youhei Sohma, Motomu Kanai, Yukiko Hori
- Organizer
  第44回神経科学大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] マイクログリアによる光酸素化Aβ代謝促進機構の解明2020
- Author(s)
  小澤柊太、谷口敦彦、清水裕介、王文博、小池礼子、横島聡、福山透、高鳥翔、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  第39回日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K06653
[Presentation] Discovery of a novel APP-dependent tau secretion2020
- Author(s)
  Haruaki Sato, Yukiko Hori, Takeshi Ikeuchi, Taisuke Tomita
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] APP依存的な新規タウ分泌現象の発見2020
- Author(s)
  佐藤玄謙、堀由起子、春日健作、池内健、富田泰輔
- Organizer
  第39回日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K06653
[Presentation] APP依存的な新規タウ分泌現象の発見2020
- Author(s)
  佐藤玄謙、堀由起子、春日健作、池内健、富田泰輔
- Organizer
  第39回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 新規光酸素化触媒による非侵襲的光酸素化反応の確立2020
- Author(s)
  堀由起子、永島臨、小澤柊太、相馬洋平、金井求、富田泰輔
- Organizer
  第39回日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K06653
[Presentation] 新規光酸素化触媒による非侵襲的光酸素化反応の確立2020
- Author(s)
  堀由起子、永島臨、小澤柊太、相馬洋平、金井求、富田泰輔
- Organizer
  第39回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Development of photooxygenation technology towards therapeutic strategy against Alzheimer disease2020
- Author(s)
  Yukiko Hori
- Organizer
  UTokyo-Cambridge Voices Workshop on the future of therapeutic development against neurodegenerative diseases
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06653
[Presentation] Photo-oxygenation by biocompatible catalyst reduced the Aβ level in the brains of Alzheimer disease model mice2020
- Author(s)
  Shuta Ozawa, Yukiko Hori, Yusuke Shimizu, Atsuhiko Taniguchi, Takanobu Suzuki, Takashi Saito, Takaomi C. Saido, Youhei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] マイクログリアによる光酸素化Aβ代謝促進機構の解明2020
- Author(s)
  小澤柊太、谷口敦彦、清水裕介、王文博、横島聡、福山透、高鳥翔、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  第39回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 光酸素化触媒を用いた新規AD治療戦略の開発2020
- Author(s)
  堀由起子
- Organizer
  第24回　Neurology SPECT定量検討会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06653
[Presentation] アルツハイマー病治療を目指した光酸素化触媒によるタウの凝集抑制2019
- Author(s)
  鈴木崇允、堀由起子、澤崎鷹、清水裕介、根本侑、小澤柊太、相馬洋平、金井求、富田泰輔
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病治療を目指した光酸素化触媒によるタウアミロイド動態制御2019
- Author(s)
  鈴木崇允、堀由起子、澤崎鷹、清水裕介、根本侑、谷口敦彦、小澤柊太、相馬洋平、金井求、富田泰輔
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Identification of the genetic regulators for Aβ production by CRISPR/Cas9.2019
- Author(s)
  Yung Wen Chiu, Ihori Ebinuma, Yukiko Hori, Taisuke Tomita
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アミロイドβ分解活性新規制御因子GPR120の同定2019
- Author(s)
  菊池一徳、木棚究、堀由起子、富田泰輔
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] The effect of synaptic adhesion molecules on in vitro tau propagation model.2019
- Author(s)
  Yu Nemoto, Yukiko Hori, Taisuke Tomita
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] dentification of genetic regulators for Aβ production by CRISPR/Cas9 based screening.2019
- Author(s)
  Yung Wen Chiu, Ihori Ebinuma, Yukiko Hori, Taisuke Tomita
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] シナプス接着分子Neuroligin2のタンパク質切断を介したGABA作動性シナプスの形成・分解制御機構の解明2019
- Author(s)
  菊池一徳、木棚究、堀由起子、富田泰輔
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 光酸素化反応による酸素化Aβの代謝機構の解析2019
- Author(s)
  堀由起子、小澤柊太、清水裕介、谷口敦彦、相馬洋平、金井求、富田泰輔
- Organizer
  日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K06653
[Presentation] 光酸素化反応による酸素化Aβの代謝機構の解析2019
- Author(s)
  堀由起子、小澤柊太、清水裕介、谷口敦彦、相馬洋平、金井求、富田泰輔
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Expression of kallikrein-related peptidase 7, an astrocyte-derived novel amyloid-β degrading protease, is negatively regulated by NMDA receptor and NF-κB signaling pathways.2019
- Author(s)
  Yuki Sudo, Kiwami Kidana, Takuya Tatebe, Yukiko Hori, Sho Takatori, Taisuke Tomita
- Organizer
  IPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アミロイドβ分解の新規制御因子GPR120の同定2019
- Author(s)
  菊池一徳、木棚究、堀由起子、富田泰輔
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Photooxygenation reduces the Ab level in the brains of Alzheimer disease model mice2019
- Author(s)
  Yukiko Hori
- Organizer
  第9回アジア・オセアニア生理学会連合大会（9th FAOPS2019）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06653
[Presentation] Transcriptional regulation of kallikrein-related peptidase 7, an astrocyte-derived amyloid-β degrading protease, in the pathogenesis of Alzheimer disease.2019
- Author(s)
  Taisuke Tomita, Yuki Sudo, Kiwami Kidana, Takuya Tatebe, Sho Takatori, Yukiko Hori
- Organizer
  IPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アストロサイト由来Aβ分解酵素Kallikrein-related peptidase 7の発現制御機構の解析2019
- Author(s)
  須藤優喜、木棚究、建部卓也、堀由起子、高鳥翔、富田泰輔
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Photooxygenation by biocompatible catalyst reduces the Aβ level in the brains of Alzheimer disease model mice.2019
- Author(s)
  Taisuke Tomita, Shuta Ozawa, Youhei Sohma, Motomu Kanai, Yukiko Hori
- Organizer
  AAIC2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病治療を目指した光酸素化触媒によるタウアミロイド動態制御2019
- Author(s)
  鈴木崇允、堀由起子、澤崎鷹、清水裕介、根本侑、谷口敦彦、小澤柊太、相馬洋平、金井求、富田泰輔
- Organizer
  日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K06653
[Presentation] The effect of synaptic adhesion molecules on in vitro tau propagation model2019
- Author(s)
  Nemoto Y, Hori Y, Tomita T
- Organizer
  Society for Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06653
[Presentation] Photooxygenation inhibits tau amyloid formation2019
- Author(s)
  Hori Y, Suzuki T, Sawazaki T, Shimizu Y, Nemoto Y, Taniguchi A, Ozawa S, Sohma Y, Kanai M, Tomita T
- Organizer
  Society for Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06653
[Presentation] Photooxygenation inhibits tau amyloid formation.2019
- Author(s)
  Yukiko Hori, Takanobu Suzuki, Taka Sawazaki, Yusuke Shimizu, Yu Nemoto, Atsuhiko Taniguchi, Shuta Ozawa, Yohei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Photooxygenation by biocompatible catalyst reduces the Aβ level in the brains of Alzheimer disease model mice.2018
- Author(s)
  Shuta Ozawa, Yukiko Hori, Takanobu Suzuki, Youhei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  Society for Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06653
[Presentation] 光酸素化触媒によるタウの酸素化は凝集を抑制する2018
- Author(s)
  鈴木崇允、堀由起子、澤崎鷹、根本侑、小澤柊太、相馬洋平、金井求、富田泰輔
- Organizer
  2018年度生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-18K06653
[Presentation] LRP1依存的なアミロイドβ取り込みを指標とした遺伝学的スクリーニング系の構築2018
- Author(s)
  松田　友亨、海老沼　五百理、堀　由起子、富田　泰輔
- Organizer
  日本薬学会　第138年会
- Data Source
  KAKENHI-PROJECT-16K18871
[Presentation] CRISPR/Cas9システムによるAβ取り込み経路関連分子のゲノムワイドスクリーニング2017
- Author(s)
  海老沼　五百理、堀　由起子、富田　泰輔
- Organizer
  2017年度　生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K18871
[Presentation] Genome wide screening of genes involved in Aβ uptake by CRISPR/Cas9 system2017
- Author(s)
  Y. Hori, I. Ebinuma, T. Tomita
- Organizer
  The 7th BRI international Symposium 2017
- Place of Presentation
  新潟大学脳研究所（新潟県、新潟市）
- Year and Date
  2017-03-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18871
[Presentation] Identification of genetic regulators for Aβ production by CRISPR/Cas9 based screening2017
- Author(s)
  Yung Wen Chiu, Ihori Ebinuma, Yukiko Hori, Taisuke Tomita
- Organizer
  2017年度　生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K18871
[Presentation] Identification of genetic regulators for Aβ production by CRISPR/Cas9 based screening2016
- Author(s)
  Yung Wen Chiu, Ihori Ebinuma, Yukiko Hori, Taisuke Tomita
- Organizer
  第38回神経組織培養研究会
- Place of Presentation
  TKPガーデンシティー（神奈川県、横浜市）
- Data Source
  KAKENHI-PROJECT-16K18871
[Presentation] Genome wide screening of molecules involved in Aβ uptake by CRISPR/Cas9 system2016
- Author(s)
  I. Ebinuma, Y. Hori, T. Tomita
- Organizer
  Society for Neuroscience 2016
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18871
[Presentation] EphA4を介したアルツハイマー病原因物質Aβ産生量制御機構の解明2015
- Author(s)
  田村謙典、堀由起子、富田泰輔
- Organizer
  第14回次世代を担う若手ファーマ・バイオフォーラム 2015
- Place of Presentation
  千葉大学亥鼻キャンパス医薬系総合研究棟（千葉）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-26893042
[Presentation] FDA APPROVED ASTHMA THERAPEUTIC AGENT IMPACTS AMYLOID BETA IN THE BRAIN IN A TRANSGENIC MODEL OF AD
- Author(s)
  Y. Hori, D.R. Elmaleh, T.M. Shoup, K. Takahashi, S. Takeda, H. Cho, D. Irimia, B.T. Hyman, E. Hudry.
- Organizer
  The 12th international conference on Alzheimer’s & Parkinson’s diseases
- Place of Presentation
  Nice (France)
- Year and Date
  2015-03-18 – 2015-03-22
- Data Source
  KAKENHI-PROJECT-26893042
[]
[]

1. Tomita Taisuke (30292957)

# of Collaborated Projects: 3 results

# of Collaborated Products: 80 results
2. 高鳥翔 (80624361)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
3. 伊藤弦太 (10431892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 樽谷愛理 (10815187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 塚越かおり (20708474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 橋本翔子 (50632890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 木村妙子 (60748820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 金井求 (20243264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
9. マラフスカカタジナ・ヨアンナ (90986374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 巽俊文 (80868232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 三ツ沼治信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 橋本唯史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hori Yukiko 堀 由起子

Research Projects

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Co-Researchers

非細胞自律的酸素化アミロイド除去機構の解明Principal Investigator

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中枢神経系プロテイノパチー発症機構の統合的解明

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Elucidation of the role of autophagy in photo-oxygenated amyloid degradation

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アプタマー生物学の創成による脳内恒常性維持機構の解明

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アプタマー生物学による脳内Aβホメオスタシス機構の意義の解明Principal Investigator

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人工的酸素付加によるアミロイド動態制御機構の解明Principal Investigator

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Elucidation of Cellular Pathogenesis as a Key Mechanism for Neurodegenerative Processes in the Pathogenesis of Dementia

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The analysis of clearance mechanism of oxygenated AbetaPrincipal Investigator

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Genome wide screening of genes involved in Abeta phagocytosis by CRISPR/Cas9 systemPrincipal Investigator

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The functional role of Eph/ephrin signal as neuron-glia communication in the regulation of brain Abeta levelPrincipal Investigator

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[Book] Geriatric Medicine（老年医学）2020

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[Journal Article] Protocol for gene knockdown using siRNA in primary cultured neonatal murine microglia2024

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[Journal Article] Identification of novel regulators involved in AD pathogenesis using the CRISPR-Cas9 system2023

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Hori Yukiko 堀由起子