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Ishiuchi Takashi  石内 崇士

ORCIDConnect your ORCID iD *help
Researcher Number 80612100
Other IDs
Affiliation (Current) 2025: 山梨大学, 大学院総合研究部, 准教授
Affiliation (based on the past Project Information) *help 2021 – 2025: 山梨大学, 大学院総合研究部, 准教授
2016 – 2020: 九州大学, 生体防御医学研究所, 助教
Review Section/Research Field
Principal Investigator
Biological Sciences / Transformative Research Areas, Section (III) / Medium-sized Section 44:Biology at cellular to organismal levels, and related fields / Basic Section 42040:Laboratory animal science-related / Basic Section 44020:Developmental biology-related / Genome biology
Except Principal Investigator
Sections That Are Subject to Joint Review: Basic Section39060:Conservation of biological resources-related , Basic Section39070:Landscape science-related / Basic Section 39070:Landscape science-related / Basic Section 39060:Conservation of biological resources-related
Keywords
Principal Investigator
エピジェネティクス / 転写 / 受精卵 / ヒストン修飾 / エピゲノム / 卵子 / 染色体操作 / エピゲノム再プログラム化 / 遺伝子発現 / ZGA … More / 全能性 / マウス胚発生 / 初期発生 / 転写因子 / 胎盤発生 / 卵子形成 / クロマチン … More
Except Principal Investigator
クローン / 体細胞 / 精子 / 凍結乾燥 / 遺伝資源 Less
  • Research Projects

    (8 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (9 People)
  •  胚性転写プログラムによる発生保証機構Principal Investigator

    • Principal Investigator
      石内 崇士
    • Project Period (FY)
      2025 – 2029
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      University of Yamanashi
  •  Development of a new technology for permanent preservation of animal genetic resources at room temperature

    • Principal Investigator
      若山 照彦
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 39060:Conservation of biological resources-related
      Basic Section 39070:Landscape science-related
      Sections That Are Subject to Joint Review: Basic Section39060:Conservation of biological resources-related , Basic Section39070:Landscape science-related
    • Research Institution
      University of Yamanashi
  •  新規染色体操作技術を用いた個体の性制御と染色体疾患モデルマウスの創出Principal Investigator

    • Principal Investigator
      石内 崇士
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42040:Laboratory animal science-related
    • Research Institution
      University of Yamanashi
  •  加齢卵子由来の受精胚が内包する発生プログラム特性の新たな理解Principal Investigator

    • Principal Investigator
      石内 崇士
    • Project Period (FY)
      2024 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
    • Research Institution
      University of Yamanashi
  •  ヒストン変異誘導により明らかにするクロマチン制御の生理学的意義Principal Investigator

    • Principal Investigator
      石内 崇士
    • Project Period (FY)
      2019
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University
  •  Epigegetic reprogramming in totipotency acquisitionPrincipal Investigator

    • Principal Investigator
      Ishiuchi Takashi
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      University of Yamanashi
      Kyushu University
  •  Functional analysis of Zfp281 during early embryogenesisPrincipal Investigator

    • Principal Investigator
      Ishiuchi Takashi
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 44020:Developmental biology-related
    • Research Institution
      Kyushu University
  •  Epigenetic dynamics during mouse oogenesisPrincipal Investigator

    • Principal Investigator
      Ishiuchi Takashi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Genome biology
    • Research Institution
      Kyushu University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

  • [Journal Article] YY1-dependent transcriptional regulation manifests at the morula stage2024

    • Author(s)
      Sakamoto Mizuki、Ishiuchi Takashi
    • Journal Title

      MicroPublication Biology

      Volume: eCollection 2024

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Journal Article] Molecular mechanisms underlying totipotency2023

    • Author(s)
      Ishiuchi Takashi、Sakamoto Mizuki
    • Journal Title

      Life Science Alliance

      Volume: 6 Issue: 11 Pages: e202302225-e202302225

    • DOI

      10.26508/lsa.202302225

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Journal Article] Dynamic nucleosome remodeling mediated by YY1 underlies early mouse development2023

    • Author(s)
      Sakamoto Mizuki、Abe Shusaku、Miki Yuka、Miyanari Yusuke、Sasaki Hiroyuki、Ishiuchi Takashi
    • Journal Title

      Genes & Development

      Volume: 37 Issue: 13-14 Pages: 590-604

    • DOI

      10.1101/gad.350376.122

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Journal Article] Healthy cloned offspring derived from freeze-dried somatic cells2022

    • Author(s)
      Wakayama Sayaka、Ito Daiyu、Hayashi Erika、Ishiuchi Takashi、Wakayama Teruhiko
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 3666-3666

    • DOI

      10.1038/s41467-022-31216-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20J23364, KAKENHI-PLANNED-19H05756
  • [Journal Article] Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes2022

    • Author(s)
      Yano Seiichi、Ishiuchi Takashi、Abe Shusaku、Namekawa Satoshi H.、Huang Gang、Ogawa Yoshihiro、Sasaki Hiroyuki
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 4440-4440

    • DOI

      10.1038/s41467-022-32141-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05214, KAKENHI-ORGANIZER-19H05749, KAKENHI-PLANNED-19H05756
  • [Journal Article] Paternally inherited H3K27me3 affects chromatin accessibility in mouse embryos produced by round spermatid injection2022

    • Author(s)
      Mizuki Sakamoto、Daiyu Ito、Rei Inoue、Sayaka Wakayama、Yasuyuki Kikuchi、Li Yang、Erika Hayashi、Rina Emura、Hirosuke Shiura、Takashi Kohda、Satoshi H. Namekawa、Takashi Ishiuchi、Teruhiko Wakayama、Masatoshi Ooga
    • Journal Title

      Development

      Volume: 149(18) Issue: 18 Pages: 18-18

    • DOI

      10.1242/dev.200696

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20J23364, KAKENHI-PLANNED-19H05756
  • [Journal Article] TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication2022

    • Author(s)
      Inatomi Teppei、Matsuda Shigeru、Ishiuchi Takashi、Do Yura、Nakayama Masunari、Abe Shusaku、Kasho Kazutoshi、Wanrooij Sjoerd、Nakada Kazuto、Ichiyanagi Kenji、Sasaki Hiroyuki、Yasukawa Takehiro、Kang Dongchon
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

      Volume: 1869 Issue: 1 Pages: 119167-119167

    • DOI

      10.1016/j.bbamcr.2021.119167

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-19H05756, KAKENHI-PROJECT-21K07127, KAKENHI-PROJECT-21K20640, KAKENHI-PROJECT-20H00530
  • [Journal Article] Reprogramming of the histone H3.3 landscape in the early mouse embryo.2021

    • Author(s)
      Ishiuchi, T., Abe, S., Inoue, K., Au Yeung, W.K., Miki, Y., Ogura, A. & Sasaki, H.
    • Journal Title

      Nature Structural & Molecular Biology

      Volume: 28 Issue: 1 Pages: 38-49

    • DOI

      10.1038/s41594-020-00521-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05214, KAKENHI-PLANNED-19H05756, KAKENHI-PLANNED-19H05758, KAKENHI-ORGANIZER-19H05749
  • [Journal Article] A histone H3.3K36M mutation in mice causes an imbalance of histone modifications and defects in chondrocyte differentiation2020

    • Author(s)
      Abe Shusaku、Nagatomo Hiroaki、Sasaki Hiroyuki、Ishiuchi Takashi
    • Journal Title

      Epigenetics

      Volume: Online ahead of print Issue: 10 Pages: 1-12

    • DOI

      10.1080/15592294.2020.1841873

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K16040, KAKENHI-PLANNED-19H05756
  • [Journal Article] Low-input ChIP-seqの現状2019

    • Author(s)
      石内崇士, 榊原祐樹, 佐々木裕之
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 72 Pages: 283-286

    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Journal Article] Zfp281 shapes the transcriptome of trophoblast stem cells and is essential for placental development2019

    • Author(s)
      Ishiuchi, T., Ohishi, H., Sato, T., Kamimura, S., Yorino, M., Abe, S., Suzuki, A., Wakayama, T., Suyama, M., Sasaki, H.
    • Journal Title

      Cell Reports

      Volume: 27 Issue: 6 Pages: 1742-1754

    • DOI

      10.1016/j.celrep.2019.04.028

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19603, KAKENHI-PROJECT-18K14717, KAKENHI-PUBLICLY-18H05102, KAKENHI-PUBLICLY-19H05267, KAKENHI-PROJECT-19H01177
  • [Presentation] Mini-oocyte誘導系の確立と卵子研究への応用2024

    • Author(s)
      阪野亜美、石内崇士
    • Organizer
      第4回有性生殖研究会
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] マウス初期胚におけるヌクレオソームポジション2023

    • Author(s)
      坂本瑞季、石内崇士
    • Organizer
      第46回日本分子生物学会年会
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] 全能性を支えるエピゲノム・転写リプログラミング2023

    • Author(s)
      石内崇士
    • Organizer
      新学術・全能性 公開シンポジウム
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] Kdm4d遺伝子欠損マウスはオス不妊を示す2023

    • Author(s)
      徐卓然、石内崇士
    • Organizer
      新学術領域「全能性プログラム」若手勉強会
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] マウス初期胚におけるヌクレオソームポジション2023

    • Author(s)
      坂本瑞季、石内崇士
    • Organizer
      新学術領域「全能性プログラム」若手勉強会
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] 卵子形成機構の包括的理解にむけた取り組み2023

    • Author(s)
      石内崇士
    • Organizer
      第1回甲信生殖発生研究会
    • Invited
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] Nucleosome organization in the early mouse embryos2022

    • Author(s)
      石内崇士
    • Organizer
      The International Symposium "Totipotency and Germ Cell Development"
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] 受精後発生における転写ダイナミクス2022

    • Author(s)
      石内崇士
    • Organizer
      第74回日本細胞生物学会大会
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] 哺乳類の初期発生の基盤となるエピゲノム制御機構2021

    • Author(s)
      石内崇士
    • Organizer
      第14回 日本エピジェネティクス研究会
    • Invited
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] 受精後発生を支えるエピゲノム・転写ネットワーク解明にむけた試み2021

    • Author(s)
      石内崇士
    • Organizer
      バイオDXシンポジウム
    • Invited
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] マウス初期発生における転写ダイナミクス2021

    • Author(s)
      石内崇士
    • Organizer
      幹細胞研究会
    • Invited
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] 受精後発生における転写ダイナミクス2021

    • Author(s)
      石内崇士
    • Organizer
      第44回 日本分子生物学会
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] エピゲノム解析が明らかにする卵子・受精卵の特性2020

    • Author(s)
      石内崇士
    • Organizer
      世界を先導するリプロダクションコアの形成研究会
    • Invited
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] マウス初期発生におけるヒストンバリアントH3.3の動態2020

    • Author(s)
      石内崇士
    • Organizer
      第93回 日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] Reprogramming of the histone H3.3 landscape in the early mouse embryo2020

    • Author(s)
      石内崇士
    • Organizer
      第43回 日本分子生物学会
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] エピゲノムと転写からアプローチする全能性デコーディング・デザイン2020

    • Author(s)
      石内崇士
    • Organizer
      配偶子インテグリティの構築・全能性プログラム 合同公開シンポジウム
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] 初期胚発生におけるエピゲノム動態2019

    • Author(s)
      石内崇士
    • Organizer
      第42回日本分子生物学会
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] 初期胚発生におけるヒストンH3バリアントの動態2019

    • Author(s)
      石内崇士
    • Organizer
      新学術領域研究「全能性プログラム:デコーディングからデザインへ」公開シンポジウム2019
    • Invited
    • Data Source
      KAKENHI-PLANNED-19H05756
  • [Presentation] Induction of a histone H3.3 K36M mutation in mice2019

    • Author(s)
      Takashi Ishiuchi, Shusaku Abe, Hiroyuki Sasaki
    • Organizer
      第13回日本エピジェネティクス研究会
    • Data Source
      KAKENHI-PUBLICLY-19H05265
  • [Presentation] Epigenetic and transcription factor-mediated pathways in developmental regulation2018

    • Author(s)
      Takashi Ishiuchi
    • Organizer
      IES meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14717
  • [Presentation] Zfp281 shapes the transcriptome of trophoblast stem cells and regulates placental development2018

    • Author(s)
      Takashi Ishiuchi
    • Organizer
      第16回幹細胞シンポジウム
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K14717
  • [Presentation] Zfp281-dependent epigenetic and transcriptional regulation in trophoblast stem cells is essential for placental development2018

    • Author(s)
      Takashi Ishiuchi, Hiroaki Ohishi, Tetsuya Sato, Shusaku Abe, Teruhiko Wakayama, Mikita Suyama, Hiroyuki Sasaki
    • Organizer
      第12回日本エピジェネティクス研究会年会
    • Data Source
      KAKENHI-PROJECT-18K14717
  • 1.  若山 照彦 (40360672)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  若山 清香 (10525918)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  永松 剛 (70453545)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  伊藤 大裕 (80981092)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  ITOH Takehiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  佐々木 裕之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 7.  鈴木 淳史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  林 哲也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  長友 啓明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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