Ishiuchi Takashi 石内崇士

Researcher Number	80612100
Other IDs
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 山梨大学, 大学院総合研究部, 准教授 2016 – 2020: 九州大学, 生体防御医学研究所, 助教
Review Section/Research Field	Principal Investigator Biological Sciences / Transformative Research Areas, Section (III) / Medium-sized Section 44:Biology at cellular to organismal levels, and related fields / Basic Section 42040:Laboratory animal science-related / Basic Section 44020:Developmental biology-related / Genome biology Except Principal Investigator Sections That Are Subject to Joint Review: Basic Section39060:Conservation of biological resources-related , Basic Section39070:Landscape science-related / Basic Section 39070:Landscape science-related / Basic Section 39060:Conservation of biological resources-related
Keywords	Principal Investigator エピジェネティクス / 転写 / 受精卵 / ヒストン修飾 / エピゲノム / 卵子 / 染色体操作 / エピゲノム再プログラム化 / 遺伝子発現 / ZGA … More / 全能性 / マウス胚発生 / 初期発生 / 転写因子 / 胎盤発生 / 卵子形成 / クロマチン … More Except Principal Investigator クローン / 体細胞 / 精子 / 凍結乾燥 / 遺伝資源 Less

胚性転写プログラムによる発生保証機構Principal Investigator
- Principal Investigator
  
  石内崇士
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  University of Yamanashi
Development of a new technology for permanent preservation of animal genetic resources at room temperature
- Principal Investigator
  
  若山照彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 39060:Conservation of biological resources-related
  Basic Section 39070:Landscape science-related
  Sections That Are Subject to Joint Review: Basic Section39060:Conservation of biological resources-related , Basic Section39070:Landscape science-related
- Research Institution
  University of Yamanashi
新規染色体操作技術を用いた個体の性制御と染色体疾患モデルマウスの創出Principal Investigator
- Principal Investigator
  
  石内崇士
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  University of Yamanashi
加齢卵子由来の受精胚が内包する発生プログラム特性の新たな理解Principal Investigator
- Principal Investigator
  
  石内崇士
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
- Research Institution
  University of Yamanashi
ヒストン変異誘導により明らかにするクロマチン制御の生理学的意義Principal Investigator
- Principal Investigator
  
  石内崇士
- Project Period (FY)
  2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Epigegetic reprogramming in totipotency acquisitionPrincipal Investigator
- Principal Investigator
  
  Ishiuchi Takashi
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Yamanashi
  Kyushu University
Functional analysis of Zfp281 during early embryogenesisPrincipal Investigator
- Principal Investigator
  
  Ishiuchi Takashi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Kyushu University
Epigenetic dynamics during mouse oogenesisPrincipal Investigator
- Principal Investigator
  
  Ishiuchi Takashi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Genome biology
- Research Institution
  Kyushu University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] YY1-dependent transcriptional regulation manifests at the morula stage2024
- Author(s)
  Sakamoto Mizuki、Ishiuchi Takashi
- Journal Title
  
  MicroPublication Biology
  
  Volume: eCollection 2024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05756
[Journal Article] Molecular mechanisms underlying totipotency2023
- Author(s)
  Ishiuchi Takashi、Sakamoto Mizuki
- Journal Title
  
  Life Science Alliance
  
  Volume: 6 Issue: 11 Pages: e202302225-e202302225
- DOI
  10.26508/lsa.202302225
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05756
[Journal Article] Dynamic nucleosome remodeling mediated by YY1 underlies early mouse development2023
- Author(s)
  Sakamoto Mizuki、Abe Shusaku、Miki Yuka、Miyanari Yusuke、Sasaki Hiroyuki、Ishiuchi Takashi
- Journal Title
  
  Genes & Development
  
  Volume: 37 Issue: 13-14 Pages: 590-604
- DOI
  10.1101/gad.350376.122
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19H05756
[Journal Article] Healthy cloned offspring derived from freeze-dried somatic cells2022
- Author(s)
  Wakayama Sayaka、Ito Daiyu、Hayashi Erika、Ishiuchi Takashi、Wakayama Teruhiko
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 3666-3666
- DOI
  10.1038/s41467-022-31216-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J23364, KAKENHI-PLANNED-19H05756
[Journal Article] Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes2022
- Author(s)
  Yano Seiichi、Ishiuchi Takashi、Abe Shusaku、Namekawa Satoshi H.、Huang Gang、Ogawa Yoshihiro、Sasaki Hiroyuki
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 4440-4440
- DOI
  10.1038/s41467-022-32141-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05214, KAKENHI-ORGANIZER-19H05749, KAKENHI-PLANNED-19H05756
[Journal Article] Paternally inherited H3K27me3 affects chromatin accessibility in mouse embryos produced by round spermatid injection2022
- Author(s)
  Mizuki Sakamoto、Daiyu Ito、Rei Inoue、Sayaka Wakayama、Yasuyuki Kikuchi、Li Yang、Erika Hayashi、Rina Emura、Hirosuke Shiura、Takashi Kohda、Satoshi H. Namekawa、Takashi Ishiuchi、Teruhiko Wakayama、Masatoshi Ooga
- Journal Title
  
  Development
  
  Volume: 149(18) Issue: 18 Pages: 18-18
- DOI
  10.1242/dev.200696
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20J23364, KAKENHI-PLANNED-19H05756
[Journal Article] TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication2022
- Author(s)
  Inatomi Teppei、Matsuda Shigeru、Ishiuchi Takashi、Do Yura、Nakayama Masunari、Abe Shusaku、Kasho Kazutoshi、Wanrooij Sjoerd、Nakada Kazuto、Ichiyanagi Kenji、Sasaki Hiroyuki、Yasukawa Takehiro、Kang Dongchon
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  
  Volume: 1869 Issue: 1 Pages: 119167-119167
- DOI
  10.1016/j.bbamcr.2021.119167
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05756, KAKENHI-PROJECT-21K07127, KAKENHI-PROJECT-21K20640, KAKENHI-PROJECT-20H00530
[Journal Article] Reprogramming of the histone H3.3 landscape in the early mouse embryo.2021
- Author(s)
  Ishiuchi, T., Abe, S., Inoue, K., Au Yeung, W.K., Miki, Y., Ogura, A. & Sasaki, H.
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 28 Issue: 1 Pages: 38-49
- DOI
  10.1038/s41594-020-00521-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05214, KAKENHI-PLANNED-19H05756, KAKENHI-PLANNED-19H05758, KAKENHI-ORGANIZER-19H05749
[Journal Article] A histone H3.3K36M mutation in mice causes an imbalance of histone modifications and defects in chondrocyte differentiation2020
- Author(s)
  Abe Shusaku、Nagatomo Hiroaki、Sasaki Hiroyuki、Ishiuchi Takashi
- Journal Title
  
  Epigenetics
  
  Volume: Online ahead of print Issue: 10 Pages: 1-12
- DOI
  10.1080/15592294.2020.1841873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16040, KAKENHI-PLANNED-19H05756
[Journal Article] Low-input ChIP-seqの現状2019
- Author(s)
  石内崇士, 榊原祐樹, 佐々木裕之
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 72 Pages: 283-286
- Data Source
  KAKENHI-PLANNED-19H05756
[Journal Article] Zfp281 shapes the transcriptome of trophoblast stem cells and is essential for placental development2019
- Author(s)
  Ishiuchi, T., Ohishi, H., Sato, T., Kamimura, S., Yorino, M., Abe, S., Suzuki, A., Wakayama, T., Suyama, M., Sasaki, H.
- Journal Title
  
  Cell Reports
  
  Volume: 27 Issue: 6 Pages: 1742-1754
- DOI
  10.1016/j.celrep.2019.04.028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19603, KAKENHI-PROJECT-18K14717, KAKENHI-PUBLICLY-18H05102, KAKENHI-PUBLICLY-19H05267, KAKENHI-PROJECT-19H01177
[Presentation] Mini-oocyte誘導系の確立と卵子研究への応用2024
- Author(s)
  阪野亜美、石内崇士
- Organizer
  第4回有性生殖研究会
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] マウス初期胚におけるヌクレオソームポジション2023
- Author(s)
  坂本瑞季、石内崇士
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] 全能性を支えるエピゲノム・転写リプログラミング2023
- Author(s)
  石内崇士
- Organizer
  新学術・全能性公開シンポジウム
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] Kdm4d遺伝子欠損マウスはオス不妊を示す2023
- Author(s)
  徐卓然、石内崇士
- Organizer
  新学術領域「全能性プログラム」若手勉強会
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] マウス初期胚におけるヌクレオソームポジション2023
- Author(s)
  坂本瑞季、石内崇士
- Organizer
  新学術領域「全能性プログラム」若手勉強会
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] 卵子形成機構の包括的理解にむけた取り組み2023
- Author(s)
  石内崇士
- Organizer
  第1回甲信生殖発生研究会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] Nucleosome organization in the early mouse embryos2022
- Author(s)
  石内崇士
- Organizer
  The International Symposium "Totipotency and Germ Cell Development"
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] 受精後発生における転写ダイナミクス2022
- Author(s)
  石内崇士
- Organizer
  第74回日本細胞生物学会大会
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] 哺乳類の初期発生の基盤となるエピゲノム制御機構2021
- Author(s)
  石内崇士
- Organizer
  第14回日本エピジェネティクス研究会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] 受精後発生を支えるエピゲノム・転写ネットワーク解明にむけた試み2021
- Author(s)
  石内崇士
- Organizer
  バイオDXシンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] マウス初期発生における転写ダイナミクス2021
- Author(s)
  石内崇士
- Organizer
  幹細胞研究会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] 受精後発生における転写ダイナミクス2021
- Author(s)
  石内崇士
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] エピゲノム解析が明らかにする卵子・受精卵の特性2020
- Author(s)
  石内崇士
- Organizer
  世界を先導するリプロダクションコアの形成研究会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] マウス初期発生におけるヒストンバリアントH3.3の動態2020
- Author(s)
  石内崇士
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] Reprogramming of the histone H3.3 landscape in the early mouse embryo2020
- Author(s)
  石内崇士
- Organizer
  第43回日本分子生物学会
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] エピゲノムと転写からアプローチする全能性デコーディング・デザイン2020
- Author(s)
  石内崇士
- Organizer
  配偶子インテグリティの構築・全能性プログラム合同公開シンポジウム
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] 初期胚発生におけるエピゲノム動態2019
- Author(s)
  石内崇士
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] 初期胚発生におけるヒストンH3バリアントの動態2019
- Author(s)
  石内崇士
- Organizer
  新学術領域研究「全能性プログラム：デコーディングからデザインへ」公開シンポジウム2019
- Invited
- Data Source
  KAKENHI-PLANNED-19H05756
[Presentation] Induction of a histone H3.3 K36M mutation in mice2019
- Author(s)
  Takashi Ishiuchi, Shusaku Abe, Hiroyuki Sasaki
- Organizer
  第13回日本エピジェネティクス研究会
- Data Source
  KAKENHI-PUBLICLY-19H05265
[Presentation] Epigenetic and transcription factor-mediated pathways in developmental regulation2018
- Author(s)
  Takashi Ishiuchi
- Organizer
  IES meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14717
[Presentation] Zfp281 shapes the transcriptome of trophoblast stem cells and regulates placental development2018
- Author(s)
  Takashi Ishiuchi
- Organizer
  第16回幹細胞シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14717
[Presentation] Zfp281-dependent epigenetic and transcriptional regulation in trophoblast stem cells is essential for placental development2018
- Author(s)
  Takashi Ishiuchi, Hiroaki Ohishi, Tetsuya Sato, Shusaku Abe, Teruhiko Wakayama, Mikita Suyama, Hiroyuki Sasaki
- Organizer
  第12回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-18K14717

1. 若山照彦 (40360672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 若山清香 (10525918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 永松剛 (70453545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 伊藤大裕 (80981092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ITOH Takehiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 佐々木裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 鈴木淳史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 林哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 長友啓明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishiuchi Takashi 石内 崇士

Research Projects

Research Products

Co-Researchers

胚性転写プログラムによる発生保証機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new technology for permanent preservation of animal genetic resources at room temperature

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規染色体操作技術を用いた個体の性制御と染色体疾患モデルマウスの創出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

加齢卵子由来の受精胚が内包する発生プログラム特性の新たな理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒストン変異誘導により明らかにするクロマチン制御の生理学的意義Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Epigegetic reprogramming in totipotency acquisitionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of Zfp281 during early embryogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Epigenetic dynamics during mouse oogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] YY1-dependent transcriptional regulation manifests at the morula stage2024

Author(s)

Journal Title

Data Source

[Journal Article] Molecular mechanisms underlying totipotency2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dynamic nucleosome remodeling mediated by YY1 underlies early mouse development2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Healthy cloned offspring derived from freeze-dried somatic cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Paternally inherited H3K27me3 affects chromatin accessibility in mouse embryos produced by round spermatid injection2022

Author(s)

Journal Title

DOI

Ishiuchi Takashi 石内崇士