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OKUYAMA Tetsuya  奥山 哲矢

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奥山 哲矢  オクヤマ テツヤ

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Researcher Number 80614966
Other IDs
Affiliation (Current) 2025: 関西医科大学, 医学部, 博士研究員
Affiliation (based on the past Project Information) *help 2023 – 2024: 関西医科大学, 医学部, 博士研究員
2021: 関西医科大学, 医学部, 博士研究員
2017: 立命館大学, 生命科学部, 助教
2013: 立命館大学, 理工学研究科, 研究員
2012: 立命館大学, 立命館グローバ ル・イノベーション研究機構, ポストドクトラルフェロー
Review Section/Research Field
Principal Investigator
Basic Section 55020:Digestive surgery-related
Except Principal Investigator
Basic Section 55060:Emergency medicine-related / Basic Section 55020:Digestive surgery-related / Basic Section 53010:Gastroenterology-related / Applied pharmacology / Molecular biology
Keywords
Principal Investigator
非コードRNA / TNF-α / 一酸化窒素 / iNOS / 肝再生 / 肝切除 / 肝移植 / 虚血再灌流障害 / 肝障害 / センスオリゴヌクレオチド … More / 誘導型一酸化窒素合成酵素 / アンチセンス転写物 / 炎症メディエーター / 肝虚血再灌流障害 / 核酸医薬 / センスオリゴ … More
Except Principal Investigator
センスオリゴヌクレオチド / 核酸医薬 / 敗血症 / 非コードRNA / 誘導型一酸化窒素合成酵素 / オルガノイド / 網羅的解析 / 炎症性サイトカイン / 肝胆膵外科 / 術後せん妄 / せん妄 / comprehensive analysis / Pancreatic Surgery / Hepatobiliary Surgery / inflammatory cytokine / delirium / 内在性アンチセンス転写物 / 肝細胞癌 / EphA2 / インターロイキン1 / 光感受性物質 / 抗体医薬 / 胆道癌 / TNF-α / 一酸化窒素 / エンドトキシン血症 / iNOS / 難治性敗血症 / 肝細胞 / センスオリゴ / 線虫 / RNA / アンチセンス転写物 Less
  • Research Projects

    (9 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (14 People)
  •  胆道がんに対するEphA2を標的とした抗体医薬の開発ー光感受物質と核酸医薬の融合ー

    • Principal Investigator
      中竹 利知
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kansai Medical University
  •  iNOSを標的とした機能付加型核酸医薬による難治性敗血症の攻略

    • Principal Investigator
      柳田 英佐
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Kansai Medical University
  •  ヒト難治性敗血症に対するインターロイキン受容体の制御を標的とした核酸医薬の開発

    • Principal Investigator
      北出 浩章
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Kansai Medical University
  •  根治不能肝細胞癌に対するEphA2遺伝子を標的とした新規核酸医薬の開発

    • Principal Investigator
      石崎 守彦
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Kansai Medical University
  •  Exploration of the pathophysiology of delirium in highly invasive surgery for hepatobiliary pancreatic cancer and its relationship to the postoperative course.

    • Principal Investigator
      舩槻 紀也
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kansai Medical University
  •  Research to develop sense oligonucleotides as novel nucleic acid drugs for hepatic ischemia-reperfusion injuryPrincipal Investigator

    • Principal Investigator
      OKUYAMA Tetsuya
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kansai Medical University
  •  iNOSセンスオリゴヌクレオチドを中心とした敗血症治療に対する基盤構築

    • Principal Investigator
      中竹 利知
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Kansai Medical University
  •  A molecular basis to develop the new nucleic acid drugs for sepsis

    • Principal Investigator
      Nishizawa Mikio
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied pharmacology
    • Research Institution
      Ritsumeikan University
  •  A search for the antisense transcripts that affect higher-order life phenomena in nematodes

    • Principal Investigator
      NISHIZAWA Mikio
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Molecular biology
    • Research Institution
      Ritsumeikan University

All 2024 2023 2022 2021 2018 2013 2012 Other

All Journal Article Presentation

  • [Journal Article] Hepatoprotection of a Standardized Extract of Cultured Lentinula edodes Mycelia against Liver Injury Induced by Ischemia-Reperfusion and Partial Hepatectomy2024

    • Author(s)
      Nakatake Richi、Okuyama Tetsuya、Ishizaki Morihiko、Yanagida Hidesuke、Kitade Hiroaki、Yoshizawa Katsuhiko、Nishizawa Mikio、Sekimoto Mitsugu
    • Journal Title

      Nutrients

      Volume: 16 Issue: 2 Pages: 256-256

    • DOI

      10.3390/nu16020256

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19KK0413, KAKENHI-PROJECT-21K09032, KAKENHI-PROJECT-23K07406, KAKENHI-PROJECT-21K08697
  • [Journal Article] Sulforaphane Is Protective against Warm Ischemia/Reperfusion Injury and Partial Hepatectomy in Rats2024

    • Author(s)
      Nakatake Richi、Okuyama Tetsuya、Hashimoto Yuki、Ishizaki Morihiko、Yanagida Hidesuke、Kitade Hiroaki、Yoshizawa Katsuhiko、Nishizawa Mikio、Sekimoto Mitsugu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 25 Issue: 1 Pages: 579-579

    • DOI

      10.3390/ijms25010579

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19KK0413, KAKENHI-PROJECT-21K09032, KAKENHI-PROJECT-23K07406, KAKENHI-PROJECT-21K08697
  • [Journal Article] Identification of Anti-Inflammatory Compounds from Peucedanum praeruptorum Roots by Using Nitric Oxide-Producing Rat Hepatocytes Stimulated by Interleukin 1β2023

    • Author(s)
      Ozaki Hiromu、Nishidono Yuto、Fujii Airi、Okuyama Tetsuya、Nakamura Kaito、Maesako Takanori、Shirako Saki、Nakatake Richi、Tanaka Ken、Ikeya Yukinobu、Nishizawa Mikio
    • Journal Title

      Molecules

      Volume: 28 Issue: 13 Pages: 5076-5076

    • DOI

      10.3390/molecules28135076

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19KK0413, KAKENHI-PROJECT-21K09032, KAKENHI-PROJECT-23K07406, KAKENHI-PROJECT-21K08697
  • [Journal Article] Hydrophobic constituents of Polygonum multiflorum roots promote renal erythropoietin expression in healthy mice2023

    • Author(s)
      Shirako Saki、Ulfa Siti Mariyah、Nishidono Yuto、Dwijayanti Dinia Rizqi、Okuyama Tetsuya、Nakatake Richi、Tanaka Ken、Ikeya Yukinobu、Nishizawa Mikio
    • Journal Title

      Journal of Natural Medicines

      Volume: 77 Issue: 4 Pages: 880-890

    • DOI

      10.1007/s11418-023-01737-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19KK0413, KAKENHI-PROJECT-21K09032, KAKENHI-PROJECT-23K07406, KAKENHI-PROJECT-21K08697
  • [Journal Article] COMBINATION THERAPY WITH A SENSE OLIGONUCLEOTIDE TO INDUCIBLE NITRIC OXIDE SYNTHASE MRNA AND HUMAN SOLUBLE THROMBOMODULIN IMPROVES SURVIVAL OF SEPSIS MODEL RATS AFTER PARTIAL HEPATECTOMY2023

    • Author(s)
      Nakatake Richi、Okuyama Tetsuya、Kotsuka Masaya、Ishizaki Morihiko、Kitade Hiroaki、Yoshizawa Katsuhiko、Tolba Rene H.、Nishizawa Mikio、Sekimoto Mitsugu
    • Journal Title

      Shock

      Volume: 60 Issue: 1 Pages: 84-91

    • DOI

      10.1097/shk.0000000000002135

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19KK0413, KAKENHI-PROJECT-21K09032, KAKENHI-PROJECT-23K07406, KAKENHI-PROJECT-21K08697
  • [Journal Article] Hepatoprotective and anti-inflammatory profile of sokeikakketsuto and makyoyokukanto in primary cultured rat hepatocytes2022

    • Author(s)
      Sakaguchi Tatsuma、Okuyama Tetsuya、Kotsuka Masaya、Yoshida Terufumi、Okumura Tadayoshi、Nishizawa Mikio、Kaibori Masaki、Sekimoto Mitsugu
    • Journal Title

      Functional Foods in Health and Disease

      Volume: 12 Issue: 2 Pages: 81-81

    • DOI

      10.31989/ffhd.v12i2.887

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08697, KAKENHI-PROJECT-21K09032
  • [Journal Article] Bitter melon fruit extract enhances intracellular ATP production and insulin secretion from rat pancreatic β-cells.2022

    • Author(s)
      Shimada T, Kato F, Dwijayanti R, Nagata T, Kinoshita A, Okuyama T, Nishizawa M, Mukai E
    • Journal Title

      British Journal of Nutrition

      Volume: 127 Issue: 3 Pages: 377-383

    • DOI

      10.1017/s0007114521001082

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08537, KAKENHI-PROJECT-21K08697, KAKENHI-PROJECT-21K09032
  • [Journal Article] Omeprazole Increases Survival Through the Inhibition of Inflammatory Mediaters in Two Rat Sepsis Models2021

    • Author(s)
      Kotsuka Masaya、Hashimoto Yuki、Nakatake Richi、Okuyama Tetsuya、Hatta Masahiko、Yoshida Terufumi、Okumura Tadayoshi、Nishizawa Mikio、Kaibori Masaki、Sekimoto Mitsugu
    • Journal Title

      Shock

      Volume: 57 Issue: 3 Pages: 444-456

    • DOI

      10.1097/shk.0000000000001897

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08697, KAKENHI-PROJECT-21K09032, KAKENHI-PROJECT-19KK0413
  • [Journal Article] Comparison of the anti-inflammatory activities of furanocoumarins from the roots of Angelica dahurica2021

    • Author(s)
      Okada Ryo、Abe Hazuki、Okuyama Tetsuya、Nishidono Yuto、Ishii Toshinari、Sato Tatsuki、Shirako Saki、Tanaka Ken、Ikeya Yukinobu、Nishizawa Mikio
    • Journal Title

      Bioactive Compounds in Health and Disease

      Volume: 4 Issue: 12 Pages: 287-287

    • DOI

      10.31989/bchd.v4i12.866

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08697, KAKENHI-PROJECT-21K09032
  • [Journal Article] A Sense Oligonucleotide to Inducible Nitric Oxide Synthase mRNA Increases the Survival Rate of Rats in Septic Shock.2018

    • Author(s)
      Nakatake R, Okuyama T, Kaibori M, Okumura T, Kon M, Nishizawa M.
    • Journal Title

      Nitric Oxide

      Volume: 72 Pages: 32-40

    • DOI

      10.1016/j.niox.2017.11.003

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K18252, KAKENHI-PROJECT-15K08602
  • [Journal Article] Active hexose correlated compound extends the lifespan and increases the thermotolerance of nematodes.2013

    • Author(s)
      Okuyama T, Yoshigai E, Ikeya Y, Nishizawa M
    • Journal Title

      Functional Foods in Health and Disease

      Volume: 3 Pages: 166-182

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24657121
  • [Journal Article] Active hexose correlated compound extends the lifespan and increases the thermotolerance of nematodes2013

    • Author(s)
      Okuyama T, Yoshigai E, Ikeya Y, Nishizawa M
    • Journal Title

      Functional Foods in Health and Disease

      Volume: 3 Pages: 166-182

    • URL

      http://functionalfoodscenter.net/files/69624283.pdf

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24657121
  • [Presentation] Identification of anti-inflammatory constituents from Alpinia zerumbet2023

    • Author(s)
      Yuto Nishidono, Toshinari Ishii, Saki Shirako, Tetsuya Okuyama, Mikio Nishizawa, Ken Tanaka
    • Organizer
      The 31st Annual Meeting of International Congress on Nutrition and Integrative Medicines (ICNIM2023)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08697
  • [Presentation] “Effects of AHCC on hepatic ischemia-reperfusion injury and partial hepatectomy in rats”2023

    • Author(s)
      Nakatake R, Okuyama T, Ishizaki M, Yanagida H, Kitade H, Yoshizawa K, Nishizawa M, Sekimoto M.
    • Organizer
      統合医療機能性食品国際学会, 統合医療機能性食品国際学会第31回年会(ICNIM2023)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09032
  • [Presentation] Investigation of the inhibitory mechanisms of plumbagin on inducible nitric oxide synthase expression in interleukin-1β-treated rat hepatocytes2023

    • Author(s)
      Tetsuya Okuyama, Richi Nakatake, Morihiko Ishizaki, Hidesuke Yanagida, Hiroaki Kitade, Mikio Nishizawa, Mitsugu Sekimoto
    • Organizer
      The 31st Annual Meeting of International Congress on Nutrition and Integrative Medicines (ICNIM2023)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08697
  • [Presentation] “Effects of AHCC on hepatic ischemia-reperfusion injury and partial hepatectomy in rats”2023

    • Author(s)
      Nakatake R, Okuyama T, Ishizaki M, Yanagida H, Kitade H, Yoshizawa K, Nishizawa M, Sekimoto M.
    • Organizer
      統合医療機能性食品国際学会, 統合医療機能性食品国際学会第31回年会(ICNIM2023)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K07406
  • [Presentation] “Investigation of the inhibitory mechanisms of plumbagin on inducible nitric oxide synthase expression in interleukin-1β-treated rat hepatocytes”2023

    • Author(s)
      Okuyama T, Nakatake R, Ishizaki M, Yanagida H, Kitade H, Yoshizawa K, Nishizawa M, Sekimoto M.
    • Organizer
      統合医療機能性食品国際学会, 統合医療機能性食品国際学会第31回年会(ICNIM2023)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09032
  • [Presentation] Effects of AHCC® on hepatic ischemia-reperfusion injury and partial hepatectomy in rats2023

    • Author(s)
      Richi Nakatake, Tetsuya Okuyama, Morihiko Ishizaki, Hidesuke Yanagida, Hiroaki Kitade, Katsuhiko Yoshizawa, Mikio Nishizawa, Mitsugu Sekimoto
    • Organizer
      The 31st Annual Meeting of International Congress on Nutrition and Integrative Medicines (ICNIM2023)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08697
  • [Presentation] “Investigation of the inhibitory mechanisms of plumbagin on inducible nitric oxide synthase expression in interleukin-1β-treated rat hepatocytes”2023

    • Author(s)
      Okuyama T, Nakatake R, Ishizaki M, Yanagida H, Kitade H, Yoshizawa K, Nishizawa M, Sekimoto M.
    • Organizer
      統合医療機能性食品国際学会, 統合医療機能性食品国際学会第31回年会(ICNIM2023)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K07406
  • [Presentation] iNOS sense oligonucleotides to treat septic shock2018

    • Author(s)
      Mikio Nishizawa, Tetsuya Okuyama, Rich Nakatake, Tadayoshi Okumura
    • Organizer
      The 8th Annual Basic Science International Conference 2018 (BaSIC 2018)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08602
  • [Presentation] 線虫C. elegansの寿命延長と熱耐性に対するAHCCの効果2013

    • Author(s)
      奥山哲矢,吉開会美,池谷幸信,西澤幹雄
    • Organizer
      第21回統合医療機能性食品国際会議(ICNIM2013)
    • Place of Presentation
      ホテルロイトン札幌,札幌(北海道)
    • Year and Date
      2013-07-27
    • Data Source
      KAKENHI-PROJECT-24657121
  • [Presentation] Active hexose correlated compound extends lifespan and increases thermotolerance of nematodes2013

    • Author(s)
      Okuyama T, Yoshigai E, Ikeya Y, Nishizawa M
    • Organizer
      The 13th International Conference of Functional Food Center and The First International Symposium of Academic Society for Functional Foods and Bioactive Compounds
    • Place of Presentation
      京都府立医科大学,京都(京都府)
    • Year and Date
      2013-05-12
    • Data Source
      KAKENHI-PROJECT-24657121
  • [Presentation] Effects of active hexose correlated compound on lifespan and stress resistance of C. elegans2013

    • Author(s)
      Okuyama T, Yoshigai E, Ikeya Y, Nishizawa M
    • Organizer
      American Society for Parenteral and Enteral Nutrition (ASPEN), Clinical Nutrition Week 2013
    • Place of Presentation
      フェニックス,アリゾナ(米国)
    • Year and Date
      2013-02-11
    • Data Source
      KAKENHI-PROJECT-24657121
  • [Presentation] Effects of Active Hexose Correlated Compound on Lifespan and Stress Resistance of C. elegans2013

    • Author(s)
      Tetsuya Okuyama, Emi Yoshigai, Yukinobu Ikeya, Mikio Nishizawa
    • Organizer
      American Society for Parenteral and Enteral Nutrition (ASPEN) Clinical Nutrition Week 2013
    • Place of Presentation
      Phoenix, USA
    • Data Source
      KAKENHI-PROJECT-24657121
  • [Presentation] 線虫C. elegansの寿命およびラット肝細胞の一酸化窒素産生に与えるAHCCの影響の比較解析2012

    • Author(s)
      奥山哲矢、吉開会美、奥村忠芳、池谷幸信、西澤幹雄
    • Organizer
      第20回統合医療機能性食品国際会議(ICNIM 2012)
    • Place of Presentation
      ホテルロイトン札幌,札幌(北海道)
    • Year and Date
      2012-07-21
    • Data Source
      KAKENHI-PROJECT-24657121
  • [Presentation] 線虫C. elegansの寿命およびラット肝細胞の一酸化窒素産生に与える AHCCの影響の比較解析2012

    • Author(s)
      奥山 哲矢、吉開 会美、奥村 忠芳、池谷 幸信、西澤 幹雄
    • Organizer
      第20回統合医療機能性食品国際会議(ICNIM 2012)
    • Place of Presentation
      ホテルロイトン札幌、北海道
    • Data Source
      KAKENHI-PROJECT-24657121
  • [Presentation] Active Hexose Correlated Compound Extends Lifespan and Increases Thermotolerance of Nematodes

    • Author(s)
      Okuyama T, Yoshigai E, Ikeya Y, Nishizawa M
    • Organizer
      The 13th International Conference of Functional Food Center and The First International Symposium of Academic Society for Functional Foods and Bioactive Compounds
    • Place of Presentation
      京都府立医科大学, 京都
    • Data Source
      KAKENHI-PROJECT-24657121
  • [Presentation] 線虫C. elegansの寿命延長と熱耐性に対するAHCCの効果

    • Author(s)
      奥山 哲矢, 吉開 会美, 池谷 幸信, 西澤 幹雄
    • Organizer
      第21回統合医療機能性食品国際会議 (ICNIM2013)
    • Place of Presentation
      ホテルロイトン札幌, 札幌
    • Data Source
      KAKENHI-PROJECT-24657121
  • 1.  中竹 利知 (40779401)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 14 results
  • 2.  NISHIZAWA Mikio (40192687)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 19 results
  • 3.  松浦 徹 (60415297)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  OKUMURA TADAYOSHI (80113140)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  海堀 昌樹 (30333199)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  寿野 良二 (60447521)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  鈴木 基史 (90807801)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  柳田 英佐 (30533252)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  北出 浩章 (20298855)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  梅垣 岳志 (20440969)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  石崎 守彦 (10509467)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 12.  舩槻 紀也 (10833064)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  嶽北 佳輝 (70548403)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  向 英里
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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