Ohhata Tatsuya 大畑樹也

… Alternative Names

OHHATA Tatsuya 大畑樹也

Less

Researcher Number	80616459
Other IDs	https://orcid.org/0000-0003-1124-6164
Affiliation (Current)	2024: 浜松医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2014 – 2024: 浜松医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Molecular biology / Basic Section 43030:Functional biochemistry-related Except Principal Investigator Medium-sized Section 50:Oncology and related fields / Basic Section 50010:Tumor biology-related / Molecular biology / Tumor biology
Keywords	Principal Investigator cisNATs / アンチセンスRNA / 非コードRNA / ノンコーディングRNA / X染色体不活性化 / エピジェネティクス / TGF-beta / Program / Epigenetics / TGFβ … More / EMT / cis-NATs / lncRNA / ダイナミクス / クロマチン / ヘテロクロマチン / Tsix / Xist / 多能性細胞 / 長鎖非コードRNA / X染色体の不活性化 … More Except Principal Investigator がん / X染色体 / 相同組換え修復 / 相同組換え / ノンコーディングRNA / 細胞運命 / シグナル伝達 / 細胞運命制御 / エピゲノム制御 / 長鎖ノンコーディングRNA / 予後診断 / 女性腫瘍 / 染色体構築・機能・分配 / X染色体不活性化 / 癌 / cancer / lncRNA Less

Elucidation of the malignant transformation mechanism of female tumors mediated by both X-chromosome activation
- Principal Investigator
  
  北川雅敏
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Hamamatsu University School of Medicine
Cell fate control by lncRNA regulating genetic specificities of epigenetic factors
- Principal Investigator
  
  北川雅敏
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Hamamatsu University School of Medicine
Molecular mechanisms of development of malignant female cancers associated with X-chromosome reactivation
- Principal Investigator
  
  北川雅敏
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Hamamatsu University School of Medicine
TGFβに応答する機能性cis-NATs群の生理・分子機構の解明Principal Investigator
- Principal Investigator
  
  大畑樹也
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Hamamatsu University School of Medicine
Elucidation of transcription-coupled facultative heterochromatin dynamicsPrincipal Investigator
- Principal Investigator
  
  Ohhata Tatsuya
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Hamamatsu University School of Medicine
Regulatory mechanism of homologous recombination in a Sex-chromosome-dependent manner
- Principal Investigator
  
  Kitagawa Masatoshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Hamamatsu University School of Medicine
Functional screening of the genes involved in Xist function and pluripotencyPrincipal Investigator
- Principal Investigator
  
  OHHATA Tatsuya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Hamamatsu University School of Medicine
Long non-coding RNA associated with cancer stemness
- Principal Investigator
  
  KITAGAWA Masatoshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Hamamatsu University School of Medicine

All 2022 2021 2019 2018 2017 2016 2015 2014

All Journal Article Presentation Book

[Book] lncRNAと疾患, ノンコーディングRNA -RNA分子の全体像を俯瞰する-2016
- Author(s)
  大畑樹也
- Total Pages
  12
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-16K07249
[Book] DOJIN BIOSCIENCEシリーズ　非コードRNA　（第29章：lncRNAと疾患）2016
- Author(s)
  大畑樹也（廣瀬哲郎・泊幸秀編）
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-26840006
[Book] ノンコーディングRNA -RNA分子の全体像を俯瞰する-2016
- Author(s)
  大畑樹也
- Total Pages
  12
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-26840006
[Journal Article] CCIVR facilitates comprehensive identification of cis-natural antisense transcripts with their structural characteristics and expression profiles2022
- Author(s)
  Ohhata Tatsuya、Suzuki Maya、Sakai Satoshi、Ota Kosuke、Yokota Hazuki、Uchida Chiharu、Niida Hiroyuki、Kitagawa Masatoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 15525-15525
- DOI
  10.1038/s41598-022-19782-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06541, KAKENHI-PROJECT-20K07308, KAKENHI-PROJECT-20K07378
[Journal Article] Homologous recombination is reduced in female embryonic stem cells by two active X chromosomes2021
- Author(s)
  Tamura Y., Ohhata, T., Niida, H., Sakai, S., Uchida C., Masumoto, K., Kotou, F., Wuts, A. and Kitagawa, M
- Journal Title
  
  EMBO Rep
  
  Volume: 22 Issue: 9
- DOI
  10.15252/embr.202052190
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08727, KAKENHI-PROJECT-19K22559, KAKENHI-PROJECT-20K07378, KAKENHI-PROJECT-21K19404
[Journal Article] Dynamics of transcription-mediated conversion from euchromatin to facultative heterochromatin at the Xist promoter by Tsix2021
- Author(s)
  Ohhata Tatsuya、Yamazawa Kazuki、Miura-Kamio Asuka、Takahashi Saori、Sakai Satoshi、Tamura Yuka、Uchida Chiharu、Kitagawa Kyoko、Niida Hiroyuki、Hiratani Ichiro、Kobayashi Hisato、Kimura Hiroshi、Wutz Anton、Kitagawa Masatoshi
- Journal Title
  
  Cell Reports
  
  Volume: 34 Issue: 13 Pages: 108912-108912
- DOI
  10.1016/j.celrep.2021.108912
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20582, KAKENHI-PLANNED-18H05527, KAKENHI-PLANNED-18H05530, KAKENHI-PROJECT-18K14681, KAKENHI-PROJECT-17K08727, KAKENHI-PROJECT-19H03628, KAKENHI-PROJECT-20K07043, KAKENHI-PROJECT-20K07378, KAKENHI-PROJECT-20K06541
[Journal Article] Long Non-coding RNA, PANDA, Contributes to the Stabilization of p53 Tumor Suppressor Protein.2016
- Author(s)
  Kotake Y, Kitagawa K, Ohhata T, Sakai S, Uchida C, Niida H, Naemura M, Kitagawa M.
- Journal Title
  
  Anticancer Res.
  
  Volume: 36 Pages: 1605-1611
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26640073
[Journal Article] Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression.2015
- Author(s)
  Ohhata T, Matsumoto M, Leeb M, Shibata S, Sakai S, Kitagawa K, Niida H, Kitagawa M, Wutz A.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 35 Issue: 22 Pages: 3909-3920
- DOI
  10.1128/mcb.00561-15
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26840006
[Presentation] Cis-Natural antisense transcripts(cis-NATs)を網羅的に同定する独自プログラムCCIVRの開発2022
- Author(s)
  大畑樹也、鈴木麻耶、酒井聡、太田幸佑、北川雅敏
- Organizer
  第45回分子生物学会
- Data Source
  KAKENHI-PROJECT-20K06541
[Presentation] メスES細胞では両X染色体の活性化により相同組換え効率が減少している2021
- Author(s)
  田村友香、大畑樹也、丹伊田浩行、酒井聡、内田千晴、増本一真、加藤文度、Anton Wuts、北川雅敏
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K19404
[Presentation] Dynamics from euchromatin to facultative heterochromatin in local gene silencing2019
- Author(s)
  Tatsuya Ohhata
- Organizer
  第6回北陸エピジェネティクス研究会
- Data Source
  KAKENHI-PROJECT-16K07249
[Presentation] 単一遺伝子座における条件的ヘテロクロマチンダイナミクス2019
- Author(s)
  Tatsuya Ohhata, Kazuki Yamasawa, Asuka Miura-kamio, Saori Takahashi, Ichiro Hiratani, Hisato Kobayashi, Hiroshi Kimura, Anton Wutz, Masatoshi Kitagawa
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K07249
[Presentation] A snapshot of facultative heterochromatin dynamics revealed by antisense long non-coding RNA Tsix2018
- Author(s)
  大畑　樹也
- Organizer
  第６回　X染色体研究会
- Data Source
  KAKENHI-PROJECT-16K07249
[Presentation] A snapshot of facultative heterochromatin dynamics revealed by antisense long non-coding RNA Tsix2018
- Author(s)
  大畑　樹也
- Organizer
  第４１回　日本分子生物学会
- Data Source
  KAKENHI-PROJECT-16K07249
[Presentation] Dynamics of faclutative heterochromatin formation at the Xist promoter evoked by antisense long non-coding RNA Tsix2017
- Author(s)
  Tatsuya Ohhata, Hiroshi Kimura, Kazuki Yamazawa, Anton Wutz, Masatoshi Kitagawa
- Organizer
  The 43rd Naito Conference on "Noncoding RNA: Biology, Chemistry, & Diseases"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07249
[Presentation] A snapshot of facultative heterochromatin dynamics revealed by antisense long non-coding RNA Tsix2017
- Author(s)
  大畑　樹也
- Organizer
  第５回　X染色体研究会
- Data Source
  KAKENHI-PROJECT-16K07249
[Presentation] アンチセンス非コードRNA Tsix による条件的ヘテロクロマチン形成機構の動的解析2017
- Author(s)
  Tatsuya Ohhata, Hiroshi Kimura, Kazuki Yamazawa, Anton Wutz, Masatoshi Kitagawa
- Organizer
  第11回日本エピジェネティクス研究会
- Data Source
  KAKENHI-PROJECT-16K07249
[Presentation] Dynamics of repressive chromatin conformation at the Xist promoter revealed by Tsix-inducible system2017
- Author(s)
  Tatsuya Ohhata
- Organizer
  第22回浜松医科学シンポジウム
- Place of Presentation
  浜松市、静岡県
- Year and Date
  2017-03-10
- Data Source
  KAKENHI-PROJECT-16K07249
[Presentation] A snapshot of facultative heterochromatin dynamics revealed by antisense long non-coding RNA Tsix2017
- Author(s)
  Tatsuya Ohhata, Hiroshi Kimura, Kazuki Yamazawa, Asuka Miura-Kamio, Hisato Kobayashi, Anton Wutz, Masatoshi Kitagawa
- Organizer
  Gordon Research Conference, Epigenetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07249
[Presentation] A snapshot of facultative heterochromatin dynamics revealed by antisense long non-coding RNA Tsix2017
- Author(s)
  大畑　樹也
- Organizer
  第４回　北陸エピジェネティクス研究会
- Data Source
  KAKENHI-PROJECT-16K07249
[Presentation] 条件的ヘテロクロマチン形成機構の解明を目指して2016
- Author(s)
  大畑樹也
- Organizer
  第一回浜松医科大学学内研究交流会
- Place of Presentation
  舘山寺温泉、浜松市
- Year and Date
  2016-07-17
- Data Source
  KAKENHI-PROJECT-26840006
[Presentation] Investigating the molecular mechanisms of Tsix antisense RNA involved in the Regulation of X-chromosome inactivation2016
- Author(s)
  Tatsuya Ohhata
- Organizer
  第3回北陸エピジェネティクス研究会
- Place of Presentation
  福井市、福井県
- Year and Date
  2016-11-21
- Data Source
  KAKENHI-PROJECT-16K07249
[Presentation] アンチセンスRNA TsixはH3K36me3をXistプロモーターに導入しXistの発現を抑制する2016
- Author(s)
  大畑樹也、松本美香、Martin Leeb、柴田進和、北川恭子、丹伊田浩行、酒井聡、Anton Wutz、北川雅敏
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜市、神奈川県
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K07249
[Presentation] Dynamics of repressive chromatin conformation at the Xist promoter revealed by Tsix-inducible system2016
- Author(s)
  Tatsuya Ohhata
- Organizer
  X chromosome inactivation -A tribute to Mary Lyon-
- Place of Presentation
  Royal society, London, UK
- Year and Date
  2016-10-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07249
[Presentation] 条件的ヘテロクロマチン形成機構の解明を目指して2016
- Author(s)
  大畑樹也
- Organizer
  第1回浜松医科大学学内研究交流会
- Place of Presentation
  舘山寺温泉、浜松市
- Year and Date
  2016-07-17
- Data Source
  KAKENHI-PROJECT-16K07249
[Presentation] Tsixの機能解明に向けての現状と展望2016
- Author(s)
  大畑樹也
- Organizer
  X染色体研究会
- Place of Presentation
  鳥取県米子市
- Year and Date
  2016-03-25
- Data Source
  KAKENHI-PROJECT-26840006
[Presentation] Histone H3 lysine 36 tri-methylation is established over the Xist promoter by antisense Tsix transcription and has a role in preventing Xist expression.2015
- Author(s)
  Tatsuya Ohhata
- Organizer
  nternational Symposium on Non-coding DNA and Chromosomal Integrity.
- Place of Presentation
  Awaji-shi, Hyogo-ken, JAPAN
- Year and Date
  2015-08-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26840006
[Presentation] アンチセンスRNA TsixはH3K36me3をXistプロモーターに導入しXistの発現を抑制している2015
- Author(s)
  大畑樹也
- Organizer
  日本RNA学会
- Place of Presentation
  北海道札幌市
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-26840006
[Presentation] Tsix発現誘導細胞を用いたTsix分子機構の解析2015
- Author(s)
  大畑樹也
- Organizer
  X染色体研究会
- Place of Presentation
  近畿大学（奈良県奈良市）
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-26840006
[Presentation] X染色体不活性化を調節するノンコーディングRNA Tsixによる遺伝子発現制御機構2014
- Author(s)
  大畑樹也
- Organizer
  名市大エピジェネティクス研究会
- Place of Presentation
  長野県南木曽町
- Year and Date
  2014-09-04
- Invited
- Data Source
  KAKENHI-PROJECT-26840006
[Presentation] 未分化ES細胞のXist発現抑制機構2014
- Author(s)
  大畑樹也
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-26840006
[Presentation] マウスES細胞におけるXistの発現抑制機構2014
- Author(s)
  大畑樹也
- Organizer
  日本遺伝学会
- Place of Presentation
  長浜バイオ大学（滋賀県長浜市）
- Year and Date
  2014-09-17
- Data Source
  KAKENHI-PROJECT-26840006

1. KITAGAWA Masatoshi (50294971)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
2. NIIDA Hiroyuki (20336671)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. 酒井聡 (50566081)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. KITAGAWA Kyoko (20299605)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. UCHIDA Chiharu (60223567)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 松本雅記 (60380531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 平谷伊智朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohhata Tatsuya 大畑 樹也

OHHATA Tatsuya 大畑 樹也

Research Projects

Research Products

Co-Researchers

Elucidation of the malignant transformation mechanism of female tumors mediated by both X-chromosome activation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cell fate control by lncRNA regulating genetic specificities of epigenetic factors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of development of malignant female cancers associated with X-chromosome reactivation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

TGFβに応答する機能性cis-NATs群の生理・分子機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of transcription-coupled facultative heterochromatin dynamicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulatory mechanism of homologous recombination in a Sex-chromosome-dependent manner

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional screening of the genes involved in Xist function and pluripotencyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Long non-coding RNA associated with cancer stemness

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] lncRNAと疾患, ノンコーディングRNA -RNA分子の全体像を俯瞰する-2016

Author(s)

Total Pages

Publisher

Data Source

[Book] DOJIN BIOSCIENCEシリーズ 非コードRNA （第29章：lncRNAと疾患）2016

Author(s)

Publisher

Data Source

[Book] ノンコーディングRNA -RNA分子の全体像を俯瞰する-2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] CCIVR facilitates comprehensive identification of cis-natural antisense transcripts with their structural characteristics and expression profiles2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Homologous recombination is reduced in female embryonic stem cells by two active X chromosomes2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dynamics of transcription-mediated conversion from euchromatin to facultative heterochromatin at the Xist promoter by Tsix2021

Author(s)

Journal Title

Ohhata Tatsuya 大畑樹也

OHHATA Tatsuya 大畑樹也

[Book] DOJIN BIOSCIENCEシリーズ　非コードRNA　（第29章：lncRNAと疾患）2016