DAIGAKU YASUKAZU 大学保一

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Daigaku Yasukazu 大学保一

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Researcher Number	80619875
Other IDs
Affiliation (Current)	2025: 公益財団法人がん研究会, がん研究所がんゲノム動態プロジェクト, プロジェクトリーダー
Affiliation (based on the past Project Information) *help	2022 – 2024: 公益財団法人がん研究会, がん研究所がんゲノム動態プロジェクト, プロジェクトリーダー 2015 – 2021: 東北大学, 学際科学フロンティア研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 43050:Genome biology-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Genome biology / Molecular and Genome biology and related fields / Molecular biology
Keywords	Principal Investigator DNA複製 / DNAポリメラーゼ / ゲノム安定性 / 突然変異 / ＤＮＡポリメラーゼ / 転写 / ＤＮＡ複製 / 転写/複製コンフリクト / RNAポリメラーゼ / 染色体編成 … More / 複製開始点 / 転写・複製コンフリクト / 突然変異生成 / ゲノムワイド解析 Less

DNA複製・RNA転写コンフリクトのゲノム科学的解析Principal Investigator
- Principal Investigator
  
  大学保一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Transaction of RNA transcription to DNA replicationPrincipal Investigator
- Principal Investigator
  
  DAIGAKU Yasukazu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Japanese Foundation for Cancer Research
  Tohoku University
DNA polymerase dynamics and genome stabilityPrincipal Investigator
- Principal Investigator
  
  DAIGAKU Yasukazu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Japanese Foundation for Cancer Research
  Tohoku University
Genome-wide identification of replicative DNA polymerase usagePrincipal Investigator
- Principal Investigator
  
  Daigaku Yasukazu
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Molecular and Genome biology and related fields
- Research Institution
  Tohoku University
Genome-wide analysis of cooperative action among DNA polymerasesPrincipal Investigator
- Principal Investigator
  
  Daigaku Yasukazu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Genome biology
- Research Institution
  Tohoku University
DNAポリメラーゼ研究におけるゲノム科学的，分子科学的アプローチの融合Principal Investigator
- Principal Investigator
  
  大学保一
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Molecular biology
- Research Institution
  Tohoku University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] NELF coordinates Pol II transcription termination and DNA replication initiation2024
- Author(s)
  Nakayama Chihiro、Daigaku Yasukazu、Aoi Yuki、Fang Qi、Kimura Hiroshi、Shilatifard Ali、Tellier Michael、Nojima Takayuki
- Journal Title
  
  BioRxiv
  
  Volume: NA
- DOI
  10.1101/2024.01.31.578294
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K24692, KAKENHI-PROJECT-23K27156
[Journal Article] Adaptive use of error‐prone DNA polymerases provides flexibility in genome replication during tumorigenesis2024
- Author(s)
  Bainbridge Lewis J.、Daigaku Yasukazu
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 7 Pages: 2125-2137
- DOI
  10.1111/cas.16188
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19203, KAKENHI-PROJECT-23K27156
[Journal Article] Global landscape of replicative DNA polymerase usage in the human genome2022
- Author(s)
  Koyanagi Eri、Kakimoto Yoko、Minamisawa Tamiko、Yoshifuji Fumiya、Natsume Toyoaki、Higashitani Atsushi、Ogi Tomoo、Carr Antony M.、Kanemaki Masato T.、Daigaku Yasukazu
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 7221-7221
- DOI
  10.1038/s41467-022-34929-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19203, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H03233, KAKENHI-PROJECT-20H00629, KAKENHI-PROJECT-21H02399
[Journal Article] Global landscape of replicative DNA polymerase usage in the human genome2021
- Author(s)
  Koyanagi Eri、Kakimoto Yoko、Yoshifuji Fumiya、Natsume Toyoaki、Higashitani Atsushi、Ogi Tomoo、Carr Antony M.、Kanemaki Masato T.、Daigaku Yasukazu
- Journal Title
  
  BioRxiv
  
  Volume: - Pages: 1-41
- DOI
  10.1101/2021.11.14.468503
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03233, KAKENHI-PROJECT-21K19203
[Journal Article] Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair2020
- Author(s)
  Nakazawa Y, Hara Y, Oka Y, Komine O, van den Heuvel D, Guo C, Daigaku Y, Isono M, He Y, Shimada M, Kato K, Jia N, Hashimoto S, Kotani Y, Miyoshi Y, Tanaka M, Sobue A, Mitsutake N, Suganami T, Masuda A, Ohno K, Nakada S, Mashimo T, Yamanaka K, Luijsterburg MS, Ogi T
- Journal Title
  
  Cell
  
  Volume: 19 Issue: 6 Pages: 1228-1244
- DOI
  10.1016/j.cell.2020.02.010
- NAID
  120006871293
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06058, KAKENHI-PROJECT-18K08508, KAKENHI-PROJECT-18K11639, KAKENHI-PROJECT-18K19585, KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-18KK0307, KAKENHI-PROJECT-17H00783, KAKENHI-PROJECT-18H03974, KAKENHI-PROJECT-17H01877, KAKENHI-PROJECT-18H03372, KAKENHI-PROJECT-16H06151, KAKENHI-PROJECT-17K12821, KAKENHI-PROJECT-19K21221
[Journal Article] Vital roles of PCNA K165 modification during C. elegans gametogenesis and embryogenesis2019
- Author(s)
  Shao Zhenhua、Niwa Shinsuke、Higashitani Atsushi、Daigaku Yasukazu
- Journal Title
  
  DNA Repair
  
  Volume: 82 Pages: 102688-102688
- DOI
  10.1016/j.dnarep.2019.102688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06151, KAKENHI-PROJECT-17H05010
[Journal Article] Spatial separation between replisome‐ and template‐induced replication stress signaling2018
- Author(s)
  Garcia‐Rodriguez Nrstor、Morawska Magdalena、Wong Ronald P、Daigaku Yasukazu、Ulrich Helle D
- Journal Title
  
  The EMBO Journal
  
  Volume: 37 Issue: 9
- DOI
  10.15252/embj.201798369
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06151
[Journal Article] PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast.2017
- Author(s)
  Daigaku Y, Etheridge TJ, Nakazawa Y, Nakayama M, Watson AT, Miyabe I, Ogi T, Osborne MA, Carr AM.
- Journal Title
  
  PLoS Genetics
  
  Volume: 13 Issue: 5 Pages: e1006789-e1006789
- DOI
  10.1371/journal.pgen.1006789
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05333, KAKENHI-PROJECT-26291005, KAKENHI-PROJECT-17H00783, KAKENHI-PROJECT-17H01877, KAKENHI-PROJECT-16H06151
[Journal Article] Polymerase δ replicates both strands after homologous recombination-dependent fork restart2015
- Author(s)
  I. Miyabe, K. Mizuno, A. Keszthelyi, Y. Daigaku, M. Skouteri, S. Mohebi, T. A. Kunkel, J. M. Murray, A. M. Carr
- Journal Title
  
  Nat. Struct. Mol. Biol.
  
  Volume: 22 Issue: 11 Pages: 932-938
- DOI
  10.1038/nsmb.3100
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06032
[Journal Article] Mapping ribonucleotides in genomic DNA and exploring replication dynamics by polymerase usage sequencing (Pu-seq)2015
- Author(s)
  A.Keszthelyi, Y. Daigaku, K. Ptasinska, I. Miyabe, A. M. Carr
- Journal Title
  
  Nat. Protocol
  
  Volume: 10 Issue: 11 Pages: 1786-1801
- DOI
  10.1038/nprot.2015.116
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06032
[Presentation] Variation in usage of leading and lagging polymerases in the human genome and its relation to the transcriptional landscape2023
- Author(s)
  Yasukazu Daigaku
- Organizer
  CSHL meeting - Eukaryotic DNA Replication & Genome Maintenance
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19203
[Presentation] Variation in usage of leading and lagging polymerases in the human genome and its relation to the transcriptional landscape2023
- Author(s)
  Yasukazu Daigaku
- Organizer
  CSHL meeting - Eukaryotic DNA Replication & Genome Maintenance
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27156
[Presentation] 細胞内・核内環境と連動するゲノム複製機構2023
- Author(s)
  大学保一, 小柳恵理, 柿本洋子, 南澤宝美后, 夏目豊彰, 鐘巻将人
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19203
[Presentation] Global usage of replicative polymerases and its relation with transcription in human cells U2023
- Author(s)
  Yasukazu Daigaku
- Organizer
  UK-Japan Genome Stability Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19203
[Presentation] 細胞内・核内環境と連動するゲノム複製機構2023
- Author(s)
  大学保一, 小柳恵理, 柿本洋子, 南澤宝美后, 夏目豊彰, 鐘巻将人
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27156
[Presentation] Chromosome fragility and DNA polymerase usage2023
- Author(s)
  Yasukazu Daigaku
- Organizer
  8th Meeting of the Asian Forum for Chromosome & Chromatin Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19203
[Presentation] Chromosome fragility and DNA polymerase usage2023
- Author(s)
  Yasukazu Daigaku
- Organizer
  8th Meeting of the Asian Forum for Chromosome & Chromatin Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27156
[Presentation] DNA polymerase dynamics and genomic instability2022
- Author(s)
  大学保一, 鐘巻将人
- Organizer
  第81回日本癌学会学術総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19203
[Presentation] DNA polymerase dynamics and genomic instability2022
- Author(s)
  大学保一, 鐘巻将人
- Organizer
  第81回日本癌学会学術総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03233
[Presentation] 遺伝子分布・転写機構が複製フォーク動態に及ぼす影響2022
- Author(s)
  大学保一, 小柳恵理, 柿本洋子, 南澤宝美后, 夏目豊彰, 鐘巻将人
- Organizer
  日本遺伝学会第94回大会
- Data Source
  KAKENHI-PROJECT-20H03233
[Presentation] DNAポリメラーゼ機能と複製フォーク動態における柔軟性と脆弱性2022
- Author(s)
  大学保一
- Organizer
  第45回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03233
[Presentation] DNAポリメラーゼ動態から見る，転写機構の染色体複製への影響2021
- Author(s)
  小柳恵理, 柿本洋子, 荻朋男, 夏目豊彰, 鐘巻将人, 大学保一
- Organizer
  第39回染色体ワークショップ・第20回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-21K19203
[Presentation] 遺伝子転写のDNAポリメラーゼ動態への影響2021
- Author(s)
  小柳恵理, 柿本洋子, 荻朋男, 夏目豊彰, 鐘巻将人, 大学保一
- Organizer
  第26回DNA複製・組換え・修復ワークショップ
- Data Source
  KAKENHI-PROJECT-20H03233
[Presentation] 核内環境に応じた複製フォーク動態の多様性2021
- Author(s)
  小柳恵理, 柿本洋子, 大学保一
- Organizer
  日本遺伝学会第92回大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03233
[Presentation] 核内環境に応じた複製フォーク動態の多様性2021
- Author(s)
  小柳恵理, 柿本洋子, 大学保一
- Organizer
  日本遺伝学会第92回大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19203
[Presentation] 遺伝子転写のDNAポリメラーゼ動態への影響2021
- Author(s)
  小柳恵理, 柿本洋子, 荻朋男, 夏目豊彰, 鐘巻将人, 大学保一
- Organizer
  第26回DNA複製・組換え・修復ワークショップ
- Data Source
  KAKENHI-PROJECT-21K19203
[Presentation] DNAポリメラーゼ動態から見る，転写機構の染色体複製への影響2021
- Author(s)
  小柳恵理, 柿本洋子, 荻朋男, 夏目豊彰, 鐘巻将人, 大学保一
- Organizer
  第39回染色体ワークショップ・第20回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-20H03233
[Presentation] ＤＮＡポリメラーゼ合成プロファイルを用いたヒト細胞における複製開始反応の定量的解析2019
- Author(s)
  吉藤郁弥,小柳恵理，荻朋男,夏目豊彰,鐘巻将人,大学保一
- Organizer
  日本遺伝学会９１回大会
- Data Source
  KAKENHI-PROJECT-16H06151
[Presentation] DNAポリメラーゼ機能から見るヒト細胞でのゲノム複製機構2019
- Author(s)
  小柳恵理，吉藤郁弥，荻朋男，夏目豊彰，鐘巻将人，大学保一
- Organizer
  第２５回DNA複製・組換え・修復ワークショップ
- Data Source
  KAKENHI-PROJECT-16H06151
[Presentation] Global usage of replicative DNA polymerase in human cells2019
- Author(s)
  Fumiya Yoshifuji, Eri Koyanagii, Tomoo Ogi, Toyoaki Natsume, Masato Kanemaki, Yasukazu Daigaku
- Organizer
  Cold Spring Harbor Laboratory Meeting "Eukaryotic DNA Replication & Genome Maintenance"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06151
[Presentation] ヒト細胞のおけるＤＮＡ複製動態の柔軟さ，危うさ2019
- Author(s)
  小柳恵理，吉藤郁弥，大学保一
- Organizer
  第４２回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H06151
[Presentation] 複製フォーク動態のゲノム科学的解析から見る染色体複製2019
- Author(s)
  大学保一
- Organizer
  第３６回染色体ワークショップ
- Data Source
  KAKENHI-PROJECT-17K19336
[Presentation] DNAポリメラーゼ機能のゲノムプロファイルから見る染色体複製システム2019
- Author(s)
  小柳恵理，吉藤郁弥，荻朋男，夏目豊彰，鐘巻将人，大学保一
- Organizer
  第３７回染色体ワークショップ
- Data Source
  KAKENHI-PROJECT-16H06151
[Presentation] Usage of error prone DNA polymerase during genome replication2018
- Author(s)
  Mayumi Nakayama, Ryoko Omi, Yasukazu Daigaku
- Organizer
  11th 3R+3C Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06151
[Presentation] 分裂酵母の複製フォークの動態から見る複製開始反応の確率的現象2018
- Author(s)
  大学保一
- Organizer
  日本遺伝学会第９０回大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H06151
[Presentation] ゲノム科学的視点から見るＤＮＡポリメラーゼ機能の柔軟性2018
- Author(s)
  大学保一
- Organizer
  第４１回分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19336
[Presentation] 染色体構造とＤＮＡ複製動態 -分裂酵母とヒト細胞の視点から-2018
- Author(s)
  大学保一
- Organizer
  染色体研究の最前線
- Invited
- Data Source
  KAKENHI-PROJECT-16H06151
[Presentation] DNA polymerase usage and mutagenesis2018
- Author(s)
  Yasukazu Daigaku
- Organizer
  JSPS-DST Japan-India Forum for Advanced Study: Epigenetics and Human Disease
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06151
[Presentation] 複製フォーク動態のゲノム科学的解析から見る染色体複製2018
- Author(s)
  大学保一、吉藤郁弥、邵震華
- Organizer
  第３６回染色体ワークショップ
- Data Source
  KAKENHI-PROJECT-16H06151
[Presentation] ゲノム科学的視点から見るＤＮＡポリメラーゼ機能の柔軟性2018
- Author(s)
  大学保一、中山真由美
- Organizer
  第４１回分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H06151
[Presentation] Usage of error prone DNA polymerase during genome replication2018
- Author(s)
  大学保一
- Organizer
  11th 3R+3C Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06151
[Presentation] 誤りがちなＤＮＡポリメラーゼＰｏｌζゲノム科学的な解析2017
- Author(s)
  大学保一，中山真由美
- Organizer
  日本遺伝学会第８９回大会
- Data Source
  KAKENHI-PROJECT-17K19336
[Presentation] ゲノム複製におけるＤＮＡポリメラーゼＰｏｌζの役割2017
- Author(s)
  大学保一，中山真由美
- Organizer
  第２４回複製・組換え・修復ワークショップ
- Data Source
  KAKENHI-PROJECT-17K19336
[Presentation] 複製クランプPCNAの分子修飾のゲノム複製における役割2016
- Author(s)
  大学保一
- Organizer
  第39回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H06151
[Presentation] 複製クランプのユビキチ化によるDNA複製機構のメンテナス2016
- Author(s)
  大学保一
- Organizer
  日本遺伝学会第88回大会プレナリーワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-16H06151
[Presentation] ゲノム複製におけるＤＮＡポリメラーゼ間での機能分担と協調性2015
- Author(s)
  大学保一、Andrea Keszthelyi、宮部泉、Antony M. Carr
- Organizer
  第３８回日本分子生物学会年会　第８８回日本生化学会大会　合同年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-15H06032

1. 野島孝之 (80431956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. Kanemaki Masato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. NAKAZAWA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 増田章男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

DAIGAKU YASUKAZU 大学 保一

Daigaku Yasukazu 大学 保一

Research Projects

Research Products

Co-Researchers

DNA複製・RNA転写コンフリクトのゲノム科学的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Transaction of RNA transcription to DNA replicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

DNA polymerase dynamics and genome stabilityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genome-wide identification of replicative DNA polymerase usagePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genome-wide analysis of cooperative action among DNA polymerasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DNAポリメラーゼ研究におけるゲノム科学的，分子科学的アプローチの融合Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] NELF coordinates Pol II transcription termination and DNA replication initiation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adaptive use of error‐prone DNA polymerases provides flexibility in genome replication during tumorigenesis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Global landscape of replicative DNA polymerase usage in the human genome2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Global landscape of replicative DNA polymerase usage in the human genome2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Vital roles of PCNA K165 modification during C. elegans gametogenesis and embryogenesis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Spatial separation between replisome‐ and template‐induced replication stress signaling2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast.2017

Author(s)

Journal Title

DAIGAKU YASUKAZU 大学保一

Daigaku Yasukazu 大学保一