Sasaki Atsuo 佐々木敦朗

Researcher Number	80620385
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 政策・メディア研究科(藤沢), 特任教授 2025: 広島大学, 病院(医), 特任教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 慶應義塾大学, 政策・メディア研究科(藤沢), 特任教授
Review Section/Research Field	Principal Investigator Basic Section 42030:Animal life science-related Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related
Keywords	Principal Investigator GTP / イノシトールリン脂質 / エネルギー代謝 / 生体恒常性 / 多細胞生物 / プロテオーム / トランスクリプトーム / p53 / がん代謝 / 代謝 … More / がん / ストレス応答 / 恒常性 / PI5P4K / シグナル伝達 Less

Exploratory research on the unveiling of new mechanisms for energy homeostasis in multicellular organismsPrincipal Investigator
- Principal Investigator
  
  佐々木敦朗
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Keio University
化学療法抵抗性再発卵巣がんにおけるp53変異・SLFN11特異的細胞障害メカニズムの解明
- Principal Investigator
  
  近藤星
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Keio University
Exploring the molecular mechanism of GTP-driven stress response systemPrincipal Investigator
- Principal Investigator
  
  Sasaki Atsuo
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Keio University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Homogeneous luminescent quantitation of cellular guanosine and adenosine triphosphates (GTP and ATP) using QT-LucGTP&ATP assay2023
- Author(s)
  Kopra Kari、Mahran Randa、Yli-Hollo Titta、Tabata Sho、Vuorinen Emmiliisa、Fujii Yuki、Vuorinen Iida、Ogawa-Iio Aki、Hirayama Akiyoshi、Soga Tomoyoshi、Sasaki Atsuo T.、H?rm? Harri
- Journal Title
  
  Analytical and Bioanalytical Chemistry
  
  Volume: 415 Issue: 27 Pages: 6689-6700
- DOI
  10.1007/s00216-023-04944-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KJ0882, KAKENHI-ORGANIZER-23H04939, KAKENHI-PROJECT-20H03165
[Journal Article] Functional molecular evolution of a <scp>GTP</scp> sensing kinase: <scp>PI5P4Kβ</scp>2023
- Author(s)
  Takeuchi Koh、Senda Miki、Ikeda Yoshiki、Okuwaki Koji、Fukuzawa Kaori、Nakagawa So、Sasaki Mika、Sasaki Atsuo T.、Senda Toshiya
- Journal Title
  
  The FEBS Journal
  
  Volume: 290 Issue: 18 Pages: 4419-4428
- DOI
  10.1111/febs.16763
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03378, KAKENHI-PROJECT-20H03165
[Journal Article] Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells2023
- Author(s)
  Ikeda Yoshiki、Davis Mindy I.、Sumita Kazutaka、Zheng Yuxiang、Kofuji Satoshi、Sasaki Mika、Hirota Yoshihisa、Pragani Rajan、Shen Min、Boxer Matthew B.、Takeuchi Koh、Senda Toshiya、Simeonov Anton、Sasaki Atsuo T.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 679 Pages: 116-121
- DOI
  10.1016/j.bbrc.2023.08.050
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18374, KAKENHI-PROJECT-21K11709, KAKENHI-PROJECT-20H03165
[Journal Article] Beyond Warburg: LDHA activates RAC for tumour growth2022
- Author(s)
  Osaka Natsuski、Sasaki Atsuo T.
- Journal Title
  
  Nature Metabolism
  
  Volume: 4 Issue: 12 Pages: 1623-1625
- DOI
  10.1038/s42255-022-00709-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165
[Journal Article] The GTP responsiveness of PI5P4Kβ evolved from a compromised trade-off between activity and specificity2022
- Author(s)
  Takeuchi Koh、Ikeda Yoshiki、Senda Miki、Harada Ayaka、Okuwaki Koji、Fukuzawa Kaori、Nakagawa So、Yu Hong Yang、Nagase Lisa、Imai Misaki、Sasaki Mika、Lo Yu-Hua、Ito Doshun、Osaka Natsuki、Fujii Yuki、Sasaki Atsuo T.、Senda Toshiya
- Journal Title
  
  Structure
  
  Volume: 30 Issue: 6 Pages: 886-899.e4
- DOI
  10.1016/j.str.2022.04.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165, KAKENHI-PROJECT-20H03378, KAKENHI-PROJECT-22KJ2661
[Journal Article] Targeting Energy Metabolism to Overcome Therapeutic Resistance of Glioblastoma and Tumor-associated Edema2021
- Author(s)
  Dasgupta Biplab、Hirota Yoshihisa、Fujii Yuki、Osaka Natsuki、Ito Doshun、Plas David R.、Sasaki Atsuo T.
- Journal Title
  
  Gliomas
  
  Volume: 1 Pages: 121-138
- DOI
  10.36255/exonpublications.gliomas.2021.chapter7
- ISBN
  9780645001747
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0455, KAKENHI-PROJECT-18K11056, KAKENHI-PROJECT-20H03165
[Journal Article] Emerging Roles of Wild-type and Mutant IDH1 in Growth, Metabolism and Therapeutics of Glioma2021
- Author(s)
  Garrett Matthew、Fujii Yuki、Osaka Natsuki、Ito Doshun、Hirota Yoshihisa、Sasaki Atsuo T.
- Journal Title
  
  Gliomas
  
  Volume: 1 Pages: 61-78
- DOI
  10.36255/exonpublications.gliomas.2021.chapter4
- ISBN
  9780645001747
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0455, KAKENHI-PROJECT-18K11056, KAKENHI-PROJECT-20H03165
[Journal Article] SI-MOIRAI: a new method to identify and quantify the metabolic fate of nucleotides2021
- Author(s)
  Ikeda Yoshiki、Hirayama Akiyoshi、Kofuji Satoshi、Hirota Yoshihisa、Kamata Ryo、Osaka Natsuki、Fujii Yuki、Sasaki Mika、Ikeda Satsuki、Smith Eric P、Bachoo Robert、Soga Tomoyoshi、Sasaki Atsuo T
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 170 Issue: 6 Pages: 699-711
- DOI
  10.1093/jb/mvab077
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165, KAKENHI-PROJECT-21K11709, KAKENHI-PROJECT-21K15019, KAKENHI-PROJECT-18KK0455
[Journal Article] Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification2021
- Author(s)
  Osaka Natsuki、Hirota Yoshihisa、Ito Doshun、Ikeda Yoshiki、Kamata Ryo、Fujii Yuki、Chirasani Venkat R.、Campbell Sharon L.、Takeuchi Koh、Senda Toshiya、Sasaki Atsuo T.
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 8 Pages: 1-12
- DOI
  10.3389/fmolb.2021.707439
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165, KAKENHI-PROJECT-21K15019
[Presentation] Workshop 2: Metabolic Targets and Vulnerabilities. Fueling the Way-The Role of Localized GTP Synthesis in Renal Cell Carcinoma Metastasis.(Presentation).2024
- Author(s)
  Aki Ogawa-Iio, Ryo Kamata, Hirofumi Yoshino, Kara Wolfe, Satoshi Kofuji, Harri H, Kari Kopra, Titta Yli-Hollo, Osamu Ogawa, Eijiro Nakamura, Takeshi Kobayashi,Satoshi Ogasawara, Takeshi Murata, Koh Takeuchi, Toshiya Senda, Tomoyoshi Soga, Akiyoshi Hirayama, Laura M Machesky, Atsuo T Sasaki.
- Organizer
  KEYSTONE SYMPOSIA on Molecular and Cellular Biology Tumor Metabolism (B3)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] GTP-sensor PI5P4Kβ counteracts anabolic stresses by lysosomal acidification.(Poster).2024
- Author(s)
  Yoshiki Ikeda, Risa Kawaguchi, Yoshihisa Hirota, Shun Kageyama, Akiyoshi Hirayama, Kazutaka Sumita,Mikako Warren, Yuki Fujii, Mika Sasaki, Kensuke Tateishi, Manabu Natsumeda, Tomoyoshi Soga, Takahisa Nakamura, Diego Perez-Tilve, Koh Takeuchi, Toshiya Senda, Atsuo T. Sasaki.
- Organizer
  KEYSTONE SYMPOSIA on Molecular and Cellular Biology Tumor Metabolism (B3)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] Targeting the GTP sensing kinase PI5P4Kβ to sensitize oxidative and nutrient stresses to suppress the metastatic potential of invasive cancer cells. (Posters).2024
- Author(s)
  Fujii Yuki. (Mentor: Atsuo Sasaki).
- Organizer
  13TH ANNUAL RESEARCH SYMPOSIUM DEPARTMENT OF INTERNAL MEDICINE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] Fueling the Way-The Role of Localized GTP Synthesis in Renal Cell Carcinoma Metastasis.(Poster) .2024
- Author(s)
  Aki OGAWA-IIO, Kari Kopra, Harri H, Satoshi Ogasawara, Ryo Kamata, Atsuo T Sasaki.
- Organizer
  KEYSTONE SYMPOSIA on Molecular and Cellular Biology Tumor Metabolism (B3)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] Identification of DNA damage response-related genes as biomarkers for castrationresistant prostate cancer. (Posters).2024
- Author(s)
  Oshima Masashi. (Mentor: Atsuo Sasaki).
- Organizer
  13TH ANNUAL RESEARCH SYMPOSIUM DEPARTMENT OF INTERNAL MEDICINE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] Fueling the Way-The Role of Localized GTP Synthesis in Renal Cell Carcinoma Metastasis. (Posters).2024
- Author(s)
  Aki Ogawa-Iio.(Mentor: Atsuo Sasaki).
- Organizer
  13TH ANNUAL RESEARCH SYMPOSIUM DEPARTMENT OF INTERNAL MEDICINE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] プロドラッグ・ミコフェノール酸モフェチルは非肝臓細胞でも活性化されるのか？(口頭発表)2023
- Author(s)
  大田祐誠,佐々木敦朗
- Organizer
  第46回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] At the Front of Cancer Metastasis -A Dynamic Role of Energy Metabolism(Presentations).2023
- Author(s)
  Atsuo T Sasaki.
- Organizer
  CANCER METASTASIS RESEARCH SYMPOSIUM.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] Role of GTP metabolism in human health and diseases2023
- Author(s)
  Atsuo Sasaki
- Organizer
  Scienc-Ome
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] Inosine monophosphate dehydrogenase drives "leadership" in collective cell migration of glioblastoma.(Posters)2023
- Author(s)
  Aki Ogawa-lio, Satoshi Kofuji, Kari Kopra, Harri H, Satoshi Ogasawara,Atsuo Sasaki.
- Organizer
  CANCER METASTASIS RESEARCH SYMPOSIUM.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] Targeting the GTP sensing kinase PI5P4Kβ to sensitize oxidative and nutrient stresses to suppress the metastatic potential of invasive cancer cells.2023
- Author(s)
  Yuki Fujii, Aki Iio (Ogawa), Shun Kageyama, Sho Tabata, Kazutaka Sumita, Mika Sasaki, Ko Takeuchi, Toshiya Senda, Atsuo T. Sasaki.
- Organizer
  CANCER METASTASIS RESEARCH SYMPOSIUM.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] Fueling the way-The Role of Localized GTP Synthesis in Cancer Metastasis(Presentations).2023
- Author(s)
  Atsuo T Sasaki.
- Organizer
  CANCER METASTASIS RESEARCH SYMPOSIUM.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] Targeting the GTP sensing kinase PI5P4Kβ to sensitize oxidative and nutrient stresses to suppress the metastatic potential of invasive cancer cells. (Posters).2023
- Author(s)
  Yuki Fujii, Aki Ogawa-lio, Shun Kageyama, Sho Tabata, Kazutaka Sumita, Mika Sasaki, Ko Takeuchi, Toshiya Senda, Atsuo Sasaki.
- Organizer
  CANCER METASTASIS RESEARCH SYMPOSIUM.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] G-SHINE プローブによる細胞内GTP 局在可視化法とその応用(口頭発表).2023
- Author(s)
  飯尾亜樹、Kari Kopra、Harri H、小笠原諭、鎌田諒、佐々木敦朗.
- Organizer
  第46回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] 時空間マルチスケール分析が照らすGTPエネルギー代謝の未踏領域（口頭発表）2023
- Author(s)
  佐々木敦朗
- Organizer
  第46回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] Role of GTP metabolism in human health and diseases2022
- Author(s)
  Atsuo Sasaki
- Organizer
  Department of Internal Medicine (DOIM) Research Conference
- Invited
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] Role of GTP metabolism in human health and diseases2022
- Author(s)
  Atsuo Sasaki
- Organizer
  2022 Cancer Symposium for Sub-Cellular Dynamics, University of Cincinnati Cancer Center
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] Role of GTP metabolism in human health and diseases2022
- Author(s)
  Atsuo Sasaki
- Organizer
  Invited speaker at the Cutting-Edge Biotechnology Laboratory Exploration
- Invited
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] GTP Energy Metabolism and Brain Tumors2021
- Author(s)
  佐々木敦朗
- Organizer
  Northwestern University, Basic Research Seminar Series
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] 生命のしなやかさと進化の鍵;GTPレジリエンス研究が拓く未来2021
- Author(s)
  佐々木敦朗
- Organizer
  日本分子生物学会年会;GTPワークショップ
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] GTP代謝研究の夜明け前2020
- Author(s)
  佐々木敦朗
- Organizer
  第４３回分子生物学会年会　ワークショップ「細胞のエネルギー制御の進化と多様化」
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] GTPエネルギーによる新たな遺伝子発現と代謝調節メカニズム2020
- Author(s)
  佐々木敦朗
- Organizer
  第２回鶴岡カンファレンス2020
- Invited
- Data Source
  KAKENHI-PROJECT-20H03165
[Presentation] GTP Energy Metabolism and Cancers2020
- Author(s)
  佐々木敦朗
- Organizer
  WFBCCC-Grand Round Seminar_Wake Forest School of Medicine
- Invited
- Data Source
  KAKENHI-PROJECT-20H03165

1. 近藤星 (90834838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 蔭山俊 (30624225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 狩野裕考 (40774279)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 廣田佳久

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 竹内恒

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Sasaki Atsuo 佐々木 敦朗

Research Projects

Research Products

Co-Researchers

Exploratory research on the unveiling of new mechanisms for energy homeostasis in multicellular organismsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

化学療法抵抗性再発卵巣がんにおけるp53変異・SLFN11特異的細胞障害メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring the molecular mechanism of GTP-driven stress response systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Homogeneous luminescent quantitation of cellular guanosine and adenosine triphosphates (GTP and ATP) using QT-LucGTP&amp;ATP assay2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional molecular evolution of a <scp>GTP</scp> sensing kinase: <scp>PI5P4Kβ</scp>2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Beyond Warburg: LDHA activates RAC for tumour growth2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The GTP responsiveness of PI5P4Kβ evolved from a compromised trade-off between activity and specificity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting Energy Metabolism to Overcome Therapeutic Resistance of Glioblastoma and Tumor-associated Edema2021

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Emerging Roles of Wild-type and Mutant IDH1 in Growth, Metabolism and Therapeutics of Glioma2021

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] SI-MOIRAI: a new method to identify and quantify the metabolic fate of nucleotides2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Workshop 2: Metabolic Targets and Vulnerabilities. Fueling the Way-The Role of Localized GTP Synthesis in Renal Cell Carcinoma Metastasis.(Presentation).2024

Author(s)

Organizer

Data Source

[Presentation] GTP-sensor PI5P4Kβ counteracts anabolic stresses by lysosomal acidification.(Poster).2024

Author(s)

Organizer

Data Source

[Presentation] Targeting the GTP sensing kinase PI5P4Kβ to sensitize oxidative and nutrient stresses to suppress the metastatic potential of invasive cancer cells. (Posters).2024

Author(s)

Organizer

Sasaki Atsuo 佐々木敦朗

[Journal Article] Homogeneous luminescent quantitation of cellular guanosine and adenosine triphosphates (GTP and ATP) using QT-LucGTP&ATP assay2023