Ehara Haruhiko 江原晴彦

Researcher Number	80634766
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級研究員
Affiliation (based on the past Project Information) *help	2023 – 2024: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 2018 – 2022: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related
Keywords	Principal Investigator 構造生物学 / Cryo-EM / クロマチン / 転写 / RNAポリメラーゼ

転写と共役したヌクレオソーム再構築の分子メカニズムの解明Principal Investigator
- Principal Investigator
  
  江原晴彦
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Cryo-EM structure analysis of transcription elongation complexesPrincipal Investigator
- Principal Investigator
  
  Ehara Haruhiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Contributions of histone tail clipping and acetylation in nucleosome transcription by RNA polymerase II2023
- Author(s)
  Oishi Takumi、Hatazawa Suguru、Kujirai Tomoya、Kato Junko、Kobayashi Yuki、Ogasawara Mitsuo、Akatsu Munetaka、Ehara Haruhiko、Sekine Shun-ichi、Hayashi Gosuke、Takizawa Yoshimasa、Kurumizaka Hitoshi
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 51 Issue: 19 Pages: 10364-10374
- DOI
  10.1093/nar/gkad754
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-23H05475, KAKENHI-PROJECT-23K20300
[Journal Article] Cryo-EM and biochemical analyses of the nucleosome containing the human histone H3 variant H3.82023
- Author(s)
  Hirai Seiya、Kujirai Tomoya、Akatsu Munetaka、Ogasawara Mitsuo、Ehara Haruhiko、Sekine Shun-ichi、Ohkawa Yasuyuki、Takizawa Yoshimasa、Kurumizaka Hitoshi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 174 Issue: 6 Pages: 549-559
- DOI
  10.1093/jb/mvad069
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15033, KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-22K19275, KAKENHI-PROJECT-22KJ0858, KAKENHI-PUBLICLY-22H04676, KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-23H05475, KAKENHI-PROJECT-23H00372, KAKENHI-PROJECT-23K20300
[Journal Article] Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA2023
- Author(s)
  Akatsu Munetaka、Ehara Haruhiko、Kujirai Tomoya、Fujita Risa、Ito Tomoko、Osumi Ken、Ogasawara Mitsuo、Takizawa Yoshimasa、Sekine Shun-ichi、Kurumizaka Hitoshi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 12 Pages: 105477-105477
- DOI
  10.1016/j.jbc.2023.105477
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15033, KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-23H05475, KAKENHI-PROJECT-23K20300
[Journal Article] Structural Basis of Damaged Nucleotide Recognition by Transcribing RNA Polymerase II in the Nucleosome2023
- Author(s)
  Osumi Ken、Kujirai Tomoya、Ehara Haruhiko、Ogasawara Mitsuo、Kinoshita Chiaki、Saotome Mika、Kagawa Wataru、Sekine Shun-ichi、Takizawa Yoshimasa、Kurumizaka Hitoshi
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 435 Issue: 13 Pages: 168130-168130
- DOI
  10.1016/j.jmb.2023.168130
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15033, KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-23H05475, KAKENHI-PROJECT-23K20300, KAKENHI-PROJECT-23K24997
[Journal Article] Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT2022
- Author(s)
  Ehara Haruhiko、Kujirai Tomoya、Shirouzu Mikako、Kurumizaka Hitoshi、Sekine Shun-ichi
- Journal Title
  
  Science
  
  Volume: 377 Issue: 6611
- DOI
  10.1126/science.abp9466
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-20H00449, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-23K20300
[Journal Article] Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H12022
- Author(s)
  Hirano Rina、Ehara Haruhiko、Kujirai Tomoya、Uejima Tamami、Takizawa Yoshimasa、Sekine Shun-ichi、Kurumizaka Hitoshi
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 7287-7287
- DOI
  10.1038/s41467-022-35003-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-20H00449, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-23K20300
[Journal Article] Structural and biochemical analyses of the nucleosome containing Komagataella pastoris histones2022
- Author(s)
  Fukushima Yutaro、Hatazawa Suguru、Hirai Seiya、Kujirai Tomoya、Ehara Haruhiko、Sekine Shun-ichi、Takizawa Yoshimasa、Kurumizaka Hitoshi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 172 Issue: 2 Pages: 79-88
- DOI
  10.1093/jb/mvac043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-20H00449, KAKENHI-PROJECT-22KJ0858, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-23K20300
[Journal Article] Structural insight into nucleosome transcription by RNA polymerase II with elongation factors2019
- Author(s)
  Ehara Haruhiko、Kujirai Tomoya、Fujino Yuka、Shirouzu Mikako、Kurumizaka Hitoshi、Sekine Shun-ichi
- Journal Title
  
  Science
  
  Volume: 363 Issue: 6428 Pages: 744-747
- DOI
  10.1126/science.aav8912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14643, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-15H04344, KAKENHI-PROJECT-19K21177
[Journal Article] Structural basis of the nucleosome transition during RNA polymerase II passage2018
- Author(s)
  Kujirai Tomoya、Ehara Haruhiko、Fujino Yuka、Shirouzu Mikako、Sekine Shun-ichi、Kurumizaka Hitoshi
- Journal Title
  
  Science
  
  Volume: 362 Issue: 6414 Pages: 595-598
- DOI
  10.1126/science.aau9904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14643, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-15H04344, KAKENHI-PROJECT-19K21177
[Presentation] クロマチン転写の構造生物学2023
- Author(s)
  江原　晴彦
- Organizer
  第23回日本蛋白質科学会年会（名古屋）
- Invited
- Data Source
  KAKENHI-PROJECT-23K20300
[Presentation] Cryo-EM analysis on the nucleosome disassembly and reassembly during transcription elongation2023
- Author(s)
  Haruhiko Ehara
- Organizer
  2023 Cold Spring Harbor meeting: Mechanisms of Eukaryotic Transcription (New York)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K20300
[Presentation] 転写伸長に伴って起こるヌクレオソームの解体と再構築過程に関する構造生物学的探究2022
- Author(s)
  Ehara Haruhiko
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K20300
[Presentation] クロマチン転写のCryo-EM解析～構造生物学のフロンティアとそれを支える技術基盤～2021
- Author(s)
  江原晴彦
- Organizer
  第421回CBI講演会「クライオ電子顕微鏡は創薬研究戦略を変えるか」
- Invited
- Data Source
  KAKENHI-PROJECT-18K14643
[Presentation] クロマチン転写のCryo-EMを用いた構造解析2020
- Author(s)
  江原晴彦,鯨井智也,藤野優佳,白水美香子,胡桃坂仁志,関根俊一
- Organizer
  日本顕微鏡学会第76回学術講演会
- Data Source
  KAKENHI-PROJECT-18K14643
[Presentation] Structural basis of chromatin transcription by RNA polymerase II and elongation factors2019
- Author(s)
  Haruhiko Ehara, Tomoya Kujirai, Yuka Fujino, Mikako Shirouzu, Hitoshi Kurumizaka, Shun-ichi Sekine
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K14643
[Presentation] Structural basis of nucleosomal transcription by RNA polymerase II2019
- Author(s)
  Haruhiko Ehara, Tomoya Kujirai, Yuka Fujino, Mikako Shirouzu, Hitoshi Kurumizaka, Shun-ichi Sekine
- Organizer
  Gordon Research Conference on Three Dimensional Electron Microscopy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14643
[Presentation] Cryo-EM analysis of nucleosomal transcription with elongation factors Elf1 and Spt4/52019
- Author(s)
  Haruhiko Ehara, Tomoya Kujirai, Yuka Fujino, Mikako Shirouzu, Hitoshi Kurumizaka, Shun-ichi Sekine
- Organizer
  Mechanisms of Eukaryotic Transcription
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14643
[Presentation] クロマチン上で起こる転写伸長の構造生物学2019
- Author(s)
  Haruhiko Ehara, Tomoya Kujirai, Yuka Fujino, Mikako Shirouzu, Hitoshi Kurumizaka, Shun-ichi Sekine
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K14643
[Presentation] クライオEMで見えてきた，ヌクレオソーム転写の分子メカニズム2019
- Author(s)
  江原　晴彦
- Organizer
  CBI学会2019年大会
- Data Source
  KAKENHI-PROJECT-18K14643
[Presentation] 転写伸長因子Elf1とSpt4/5のクロマチン上での転写伸長における役割2018
- Author(s)
  Ehara Haruhiko、Kujirai Tomoya、Fujino Yuka、Shirouzu Mikako、Kurumizaka Hitoshi、Sekine Shun-ichi
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K14643
[Presentation] Cryo-EM analysis of RNA polymerase II transcribing a nucleosomal DNA2018
- Author(s)
  Ehara Haruhiko、Kujirai Tomoya、Fujino Yuka、Shirouzu Mikako、Kurumizaka Hitoshi、Sekine Shun-ichi
- Organizer
  2018 Kuo Symposium on 3D-EM of Macromolecules and Cells
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14643

1. 鯨井智也 (70823566)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. 関根俊一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 滝沢由政

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Ehara Haruhiko 江原 晴彦

Research Projects

Research Products

Co-Researchers

転写と共役したヌクレオソーム再構築の分子メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cryo-EM structure analysis of transcription elongation complexesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Contributions of histone tail clipping and acetylation in nucleosome transcription by RNA polymerase II2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cryo-EM and biochemical analyses of the nucleosome containing the human histone H3 variant H3.82023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural Basis of Damaged Nucleotide Recognition by Transcribing RNA Polymerase II in the Nucleosome2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H12022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural and biochemical analyses of the nucleosome containing Komagataella pastoris histones2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural insight into nucleosome transcription by RNA polymerase II with elongation factors2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis of the nucleosome transition during RNA polymerase II passage2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] クロマチン転写の構造生物学2023

Author(s)

Organizer

Data Source

[Presentation] Cryo-EM analysis on the nucleosome disassembly and reassembly during transcription elongation2023

Author(s)

Organizer

Data Source

[Presentation] 転写伸長に伴って起こるヌクレオソームの解体と再構築過程に関する構造生物学的探究2022

Author(s)

Organizer

Data Source

[Presentation] クロマチン転写のCryo-EM解析 ～構造生物学のフロンティアとそれを支える技術基盤～2021

Author(s)

Organizer

Data Source

[Presentation] クロマチン転写のCryo-EMを用いた構造解析2020

Author(s)

Organizer

Ehara Haruhiko 江原晴彦

[Presentation] クロマチン転写のCryo-EM解析～構造生物学のフロンティアとそれを支える技術基盤～2021