Ouchi Ayumi 大内亜由美

… Alternative Names

大内亜由美オオウチアユミ

臼井亜由美ウスイアユミ

Less

Researcher Number	80645664
Other IDs
Affiliation (Current)	2025: 順天堂大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 順天堂大学, 医学部, 准教授 2017 – 2019: 順天堂大学, 医学部, 非常勤助教 2014 – 2016: 順天堂大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 56060:Ophthalmology-related / Ophthalmology
Keywords	Principal Investigator 糖尿病網膜症 / マイクログリア / 網膜オルガノイド / 網膜3次元培養 / 神経血管グリアユニット / 網膜３次元培養 / 網膜新生血管 / 網膜マイクログリア / 加齢黄斑変性症 / 未熟児網膜症 … More / 網膜血管新生 / 硝子体 / 網膜色素上皮細胞 / microRNA-21 / microRNA / 上皮間葉系移行 / マイクロRNA / 増殖硝子体網膜症 / 増殖糖尿病網膜症 Less

Research Projects
(4 results)
Research Products
(30 results)

ヒト網膜オルガノイドとマイクログリア共培養系を用いた難治性網膜疾患の病態解明Principal Investigator
- Principal Investigator
  
  大内亜由美
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Juntendo University
ヒト網膜オルガノイドとマイクログリア共培養系を用いた糖尿病網膜症メカニズムの解明Principal Investigator
- Principal Investigator
  
  大内亜由美
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Juntendo University
The molecular and functional analysis of retinal microglia in diabetic retinopathyPrincipal Investigator
- Principal Investigator
  
  Usui-Ouchi Ayumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Juntendo University
Investigation of microNRA expression and function in vitreous of proliferative vitreoretinal diseases.Principal Investigator
- Principal Investigator
  
  Ouchi Ayumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Juntendo University

All 2023 2022 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Integrating human iPSC‐derived macrophage progenitors into retinal organoids to generate a mature retinal microglial niche2023
- Author(s)
  Usui‐Ouchi Ayumi、Giles Sarah、Harkins‐Perry Sarah、Mills Elizabeth A.、Bonelli Roberto、Wei Guoqin、Ouchi Yasuo、Ebihara Nobuyuki、Nakao Shintaro、Friedlander Martin、Eade Kevin T.
- Journal Title
  
  Glia
  
  Volume: 71 Issue: 10 Pages: 2372-2382
- DOI
  10.1002/glia.24428
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0291, KAKENHI-PROJECT-21K09727
[Journal Article] Galectin-3, a damage-associated molecular pattern, in tears of patients with vernal keratoconjunctivitis2023
- Author(s)
  Ito Yousuke、Usui-Ouchi Ayumi、Ebihara Nobuyuki
- Journal Title
  
  Japanese Journal of Ophthalmology
  
  Volume: 67 Issue: 4 Pages: 431-439
- DOI
  10.1007/s10384-023-00994-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09727
[Journal Article] Deletion of Tgfβ signal in activated microglia prolongs hypoxia‐induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis2022
- Author(s)
  Usui‐Ouchi Ayumi、Eade Kevin、Giles Sarah、Ideguchi Yoichiro、Ouchi Yasuo、Aguilar Edith、Wei Guoqin、Marra Kyle V.、Berlow Rebecca B.、Friedlander Martin
- Journal Title
  
  Glia
  
  Volume: 70 Issue: 9 Pages: 1762-1776
- DOI
  10.1002/glia.24218
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09727, KAKENHI-PROJECT-20K07651
[Journal Article] Retinal Disease and Metabolism2022
- Author(s)
  Fu Zhongjie、Usui-Ouchi Ayumi、Allen William、Tomita Yohei
- Journal Title
  
  Life
  
  Volume: 12 Issue: 2 Pages: 183-183
- DOI
  10.3390/life12020183
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09727
[Journal Article] Retinal microglia are critical for subretinal neovascular formation2020
- Author(s)
  Usui-Ouchi Ayumi、Usui Yoshihiko、 Kurihara Toshihide、 Aguilar Edith、Dorrell Michael、Ideguchi Yoichiro、Sakimoto Susumu、Bravo Stephen、and Friedlander Martin
- Journal Title
  
  JCI insight
  
  Volume: in press
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16984
[Journal Article] 飛蚊症の自覚から網膜剥離発見までの期間について2019
- Author(s)
  佐久間俊郎, 大内亜由美, 坂西良仁, 伊藤玲, 清川正敏, 海老原伸行
- Journal Title
  
  眼科臨床紀要
  
  Volume: 12 (1) Pages: 5-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16984
[Journal Article] Anti-VEGF therapy: higher potency and long-lasting antagonism are not necessarily better2019
- Author(s)
  Usui-Ouchi Ayumi、Friedlander Martin
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 129 Issue: 8 Pages: 3032-3034
- DOI
  10.1172/jci129862
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16984
[Journal Article] Three Cases of Creutzfeldt-Jakob Disease with Visual Disturbances as Initial Manifestation2019
- Author(s)
  Sakuma Toshiro、Watanabe Satoshi、Ouchi Ayumi、Sakanishi Yoshihito、Mizota Atsushi、Ebihara Nobuyuki
- Journal Title
  
  Case Reports in Ophthalmology
  
  Volume: 10 Issue: 3 Pages: 349-356
- DOI
  10.1159/000503274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16984
[Journal Article] 特集第71回日本臨床眼科学会講演集[6] 原著治療開始後に肺結核への罹患が判明した糖尿病網膜症3例2018
- Author(s)
  玉城麻夏、大内亜由美、坂西良仁、李亜美、海老原伸行
- Journal Title
  
  臨床眼科
  
  Volume: 72 Issue: 8 Pages: 1161-1167
- DOI
  10.11477/mf.1410212793
- ISSN
  0370-5579, 1882-1308
- Year and Date
  2018-08-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16984
[Journal Article] 基礎研究コラム 15．microRNAの臨床応用の可能性2018
- Author(s)
  大内亜由美
- Journal Title
  
  あたらしい眼科
  
  Volume: 35(8) Pages: 1099-1099
- Data Source
  KAKENHI-PROJECT-17K16984
[Journal Article] Short-term outcomes in patients with branch retinal vein occlusion who received intravitreal aflibercept with or without intravitreal ranibizumab.2017
- Author(s)
  Sakanishi Y, Usui-Ouchi A, Tamaki K, Mashimo K, Ito R, Ebihara N.
- Journal Title
  
  Clin Ophthalmol.
  
  Volume: 3 Pages: 829-834
- DOI
  10.2147/opth.s133594
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16984
[Journal Article] Effects of Secreted Mast Cell Mediators on Retinal Pigment Epithelial Cells: Focus on Mast Cell Tryptase.2017
- Author(s)
  Arai R, Usui-Ouchi A, Ito Y, Mashimo K, Murakami A, Ebihara N.
- Journal Title
  
  Mediators Inflamm.
  
  Volume: 29 Pages: 3124753-3124753
- DOI
  10.1155/2017/3124753
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16984
[Journal Article] The peroxisome proliferator-activated receptor pan-agonist bezafibrate suppresses microvascular inflammatory responses of retinal endothelial cells and vascular endothelial growth factor production in retinal pigmented epithelial cells.2017
- Author(s)
  Usui-Ouchi A, Ouchi Y, Ebihara N.
- Journal Title
  
  Int Immunopharmacol.
  
  Volume: 52 Pages: 70-76
- DOI
  10.1016/j.intimp.2017.08.027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16984
[Journal Article] Upregulation of Mir-21 Levels in the Vitreous Humor Is Associated with Development of Proliferative Vitreoretinal Disease2016
- Author(s)
  Ayumi Usui-Ouchi, Yasuo Ouchi, Masatoshi Kiyokawa, Toshiro Sakuma, Rei Ito, Nobuyuki Ebihara
- Journal Title
  
  PLOS ONE
  
  Volume: 11 Issue: 6 Pages: e0158043-e0158043
- DOI
  10.1371/journal.pone.0158043
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26861469, KAKENHI-PROJECT-26870683
[Journal Article] 眼科医のための先端医療(第159回)　網膜細胞分化におけるエピジェネティック機構とmicroRNAの役割(解説)2014
- Author(s)
  臼井亜由美
- Journal Title
  
  あたらしい眼科
  
  Volume: 31 Pages: 383-385
- Data Source
  KAKENHI-PROJECT-26861469
[Presentation] 糖尿病網膜症における網膜マイクログリアの機能と極性制御の解明2023
- Author(s)
  大内亜由美
- Organizer
  第３８回糖尿病合併症学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K09727
[Presentation] 糖尿病網膜症における虚血と炎症への挑戦2023
- Author(s)
  大内亜由美
- Organizer
  第62回網膜硝子体学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-22KK0291
[Presentation] 糖尿病黄斑浮腫症に対するファリシマブへの切り替えによる短期成績と反応性の検討2023
- Author(s)
  大内亜由美，松澤萌，二宮以信，坂西良仁，藤井達也，海老原伸行
- Organizer
  第77回日本臨床眼科学会
- Data Source
  KAKENHI-PROJECT-22KK0291
[Presentation] 糖尿病黄斑浮腫症に対するファリシマブへの切り替えによる短期成績と反応性の検討2023
- Author(s)
  大内亜由美，松澤　萌，二宮以信，坂西良仁，藤井達也，海老原伸行
- Organizer
  第77回日本臨床眼科学会
- Data Source
  KAKENHI-PROJECT-21K09727
[Presentation] 糖尿病網膜症における虚血と炎症への挑戦2023
- Author(s)
  大内亜由美
- Organizer
  第６２回網膜硝子体学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K09727
[Presentation] 虚血網膜症モデルにおけるASIC1a特異的阻害抗体の効果2023
- Author(s)
  大内亜由美, Aguilar E, Qiang M, 岸下秀太, Guang Y, Friedlander M, 海老原伸行
- Organizer
  第127回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-22KK0291
[Presentation] 虚血網膜症モデルにおけるASIC1a特異的阻害抗体の効果2023
- Author(s)
  大内亜由美, Aguilar E, Qiang M, 岸下秀太, Guang Y, Friedlander M, 海老原伸行
- Organizer
  第127回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-21K09727
[Presentation] 糖尿病網膜症における網膜マイクログリアの機能と極性制御の解明2023
- Author(s)
  大内亜由美
- Organizer
  第38回糖尿病合併症学会
- Invited
- Data Source
  KAKENHI-PROJECT-22KK0291
[Presentation] ヒトiPS細胞由来網膜オルガノイドとマイクログリアの新規共培養モデルの開発2022
- Author(s)
  大内亜由美, Kevin Eade, Sarah Giles, Martin Friedlander, 海老原伸行
- Organizer
  第１２６回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-21K09727
[Presentation] New co-culture system of human iPSC induced retinal organoid and microglia2022
- Author(s)
  Ayumi Usui-Ouchi, Sarah Giles, Kevin Eade, Nobuyuki Ebihara, Martin Friedlander
- Organizer
  The association for research in vision and ophthalmology（ARVO）annual meeting 2022
- Data Source
  KAKENHI-PROJECT-21K09727
[Presentation] Extracellular vesicles shed from endothelial colony forming seeks (ECFCs) with high expression of CD44 are paracrine mediators of neurovasculotrophic retinal repair.2019
- Author(s)
  Kyle Marra, Edith Aguilar, Ayumi Ouchi, Susumu Sakimoto, Martin Friedlander
- Organizer
  ARVO annual meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16984
[Presentation] The role of Acid-sensing ion channel 1a in a mouse model of ischemic retinopathy2019
- Author(s)
  Ayumi Ouchi, Edith Aguilar, Kyle Marra, Min Qiang, Yang Guang, Richard Lerner, Martin Friedlander
- Organizer
  ARVO annual meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16984
[Presentation] ヒト網膜色素上皮細胞株におけるmicroRNA-21の発現と機能解析2015
- Author(s)
  大内亜由美　海老原伸行
- Organizer
  第１１９回　日本眼科学会総会
- Place of Presentation
  ロイトン札幌（札幌）
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-26861469
[Presentation] ヒト網膜色素上皮細胞株における microRNA-21 の発現と機能解析
- Author(s)
  大内亜由美、海老原伸行
- Organizer
  第１１９回　日本眼科学会総会
- Place of Presentation
  ロイトン札幌（札幌）
- Year and Date
  2015-04-16 – 2015-04-19
- Data Source
  KAKENHI-PROJECT-26861469
[Presentation] 眼内増殖疾患の硝子体中における分泌型 microRNA の発現解析
- Author(s)
  臼井亜由美、玉城和範、清川正敏、佐久間俊郎、伊藤玲、Razak Siti Razila Abdul、渡辺すみ子
- Organizer
  第１１８回　日本眼科学会総会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2014-04-02 – 2014-04-06
- Data Source
  KAKENHI-PROJECT-26861469

Ouchi Ayumi 大内 亜由美

大内 亜由美 オオウチ アユミ

臼井 亜由美 ウスイ アユミ

Research Projects

Research Products

ヒト網膜オルガノイドとマイクログリア共培養系を用いた難治性網膜疾患の病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒト網膜オルガノイドとマイクログリア共培養系を用いた糖尿病網膜症メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The molecular and functional analysis of retinal microglia in diabetic retinopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of microNRA expression and function in vitreous of proliferative vitreoretinal diseases.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Integrating human iPSC‐derived macrophage progenitors into retinal organoids to generate a mature retinal microglial niche2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Galectin-3, a damage-associated molecular pattern, in tears of patients with vernal keratoconjunctivitis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deletion of Tgfβ signal in activated microglia prolongs hypoxia‐induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Retinal Disease and Metabolism2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Retinal microglia are critical for subretinal neovascular formation2020

Author(s)

Journal Title

Data Source

[Journal Article] 飛蚊症の自覚から網膜剥離発見までの期間について2019

Author(s)

Journal Title

Data Source

[Journal Article] Anti-VEGF therapy: higher potency and long-lasting antagonism are not necessarily better2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Three Cases of Creutzfeldt-Jakob Disease with Visual Disturbances as Initial Manifestation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 特集 第71回日本臨床眼科学会講演集[6] 原著 治療開始後に肺結核への罹患が判明した糖尿病網膜症3例2018

Author(s)

Journal Title

DOI

ISSN

Year and Date

Data Source

[Journal Article] 基礎研究コラム 15．microRNAの臨床応用の可能性2018

Author(s)

Journal Title

Data Source

[Journal Article] Short-term outcomes in patients with branch retinal vein occlusion who received intravitreal aflibercept with or without intravitreal ranibizumab.2017

Author(s)

Ouchi Ayumi 大内亜由美

大内亜由美オオウチアユミ

臼井亜由美ウスイアユミ

[Journal Article] 特集第71回日本臨床眼科学会講演集[6] 原著治療開始後に肺結核への罹患が判明した糖尿病網膜症3例2018

[Journal Article] 眼科医のための先端医療(第159回)　網膜細胞分化におけるエピジェネティック機構とmicroRNAの役割(解説)2014