Takeda Haruna 武田はるな

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TAKEDA Haruna 武田はるな

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Researcher Number	80647975
Other IDs	https://orcid.org/0000-0002-1643-2524
Affiliation (Current)	2024: 国立研究開発法人国立がん研究センター, 研究所, ユニット長
Affiliation (based on the past Project Information) *help	2019 – 2022: 国立研究開発法人国立がん研究センター, 研究所, ユニット長 2016 – 2018: 金沢大学, がん進展制御研究所, 助教 2014 – 2015: 金沢医科大学, 医学部, 助教 2013: 東京大学, 医学(系)研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Tumor biology / Medium-sized Section 50:Oncology and related fields / Basic Section 50010:Tumor biology-related / Pathological medical chemistry
Keywords	Principal Investigator マウスモデル / スクリーニング / トランスポゾン / 大腸がん / マウス / 大腸炎 / モデルマウス / オルガノイド / 遺伝子 / 炎症 … More / 消化管 / がん / DSS / がん関連遺伝子 / エピジェネティクス / CRISPR / 慢性炎症 / 生体内スクリーニング / 動物 / 遺伝学 / ゲノム / 癌 / 治療抵抗性 / 薬剤耐性 / がん抑制遺伝子 / 薬剤抵抗性 / ドライバー遺伝子 / CRISPR-Cas9 / 大腸がん抑制遺伝子 / がんドライバー遺伝子 / 挿入変異誘発法 / 胃 / 遺伝子スクリーニング Less

Identification and validation of colitis associated cancer driver genes.Principal Investigator
- Principal Investigator
  
  武田はるな
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  National Cancer Center Japan
Identification and functional validation of novel therapeutic targets for colorectal cancer using forward genetic approaches in micePrincipal Investigator
- Principal Investigator
  
  Takeda Haruna
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  National Cancer Center Japan
Identification of colorectal cancer driver genes involved in cancer development and therapeutic resistance.Principal Investigator
- Principal Investigator
  
  Takeda Haruna
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  National Cancer Center Japan
  Kanazawa University
Identification and validation of gastric cancer genesPrincipal Investigator
- Principal Investigator
  
  Takeda Haruna
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kanazawa University
  Kanazawa Medical University
Analysis of the role of inflammation on gastric cancer formation using a mouse modelPrincipal Investigator
- Principal Investigator
  
  TAKEDA Haruna
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kanazawa Medical University
  The University of Tokyo

All 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Characterization of RNF43 frameshift mutations that drive Wnt ligand‐ and R‐spondin‐dependent colon cancer2022
- Author(s)
  Yamamoto Daisuke、Oshima Hiroko、Wang Dong、Takeda Haruna、Kita Kenji、Lei Xuelian、Nakayama Mizuho、Murakami Kazuhiro、Ohama Takashi、Takemura Hirofumi、Toyota Mutsumi、Suzuki Hiromu、Inaki Noriyuki、Oshima Masanobu
- Journal Title
  
  The Journal of Pathology
  
  Volume: 257 Issue: 1 Pages: 39-52
- DOI
  10.1002/path.5868
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04030, KAKENHI-PROJECT-19H03498, KAKENHI-PROJECT-20H03522, KAKENHI-PROJECT-21K19421, KAKENHI-PROJECT-21K15502, KAKENHI-PROJECT-22H00454, KAKENHI-PROJECT-20K07586
[Journal Article] A Platform for Validating Colorectal Cancer Driver Genes Using Mouse Organoids.2021
- Author(s)
  Haruna Takeda
- Journal Title
  
  Frontiers in genetics
  
  Volume: 12 Pages: 698771-69877
- DOI
  10.3389/fgene.2021.698771
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03522, KAKENHI-PROJECT-21K19421
[Journal Article] A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells2021
- Author(s)
  Murakami Kazuhiro、Terakado Yumi、Saito Kikue、Jomen Yoshie、Takeda Haruna、Oshima Masanobu、Barker Nick
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 4 Pages: 1-12
- DOI
  10.1073/pnas.2016806118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03522, KAKENHI-PROJECT-20K07586
[Journal Article] Identification of cancer driver genes using Sleeping Beauty transposon mutagenesis2021
- Author(s)
  Takeda Haruna、Jenkins Nancy A.、Copeland Neal G.
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 6 Pages: 2089-2096
- DOI
  10.1111/cas.14901
- Data Source
  KAKENHI-PROJECT-20H03522
[Journal Article] CRISPR-Cas9と消化管由来オルガノイドを用いた大腸がんドライバー遺伝子の機能検証2020
- Author(s)
  武田はるな
- Journal Title
  
  消化器病学サイエンス
  
  Volume: 4 Pages: 55-58
- Data Source
  KAKENHI-PROJECT-17H03586
[Journal Article] CRISPR-Cas9 mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes.2019
- Author(s)
  Takeda H, Kataoka S, Nakayama M, Ali MAE, Oshima H, Yamamoto D, Park JW, Takegami Y, An T, Jenkins NA, Copeland NG, and Oshima M.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 116 Issue: 31 Pages: 15635-15644
- DOI
  10.1073/pnas.1904714116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22558, KAKENHI-PROJECT-18H04030, KAKENHI-PROJECT-17H03586, KAKENHI-PROJECT-19H03498
[Journal Article] p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia2017
- Author(s)
  1.Sarah P. Short, Jumpei Kondo, Whitney G. Smalley-Freed, Haruna Takeda, Michael R. Dohn, Anne E. Powell, Robert H. Carnahan, Mary K. Washington, Manish Tripathi, D. Michael Payne, Nancy A. Jenkins, Neal G. Copeland, Robert J. Coffey and Albert B. Reynolds
- Journal Title
  
  J Clin Invest.
  
  Volume: 127 Pages: 4462-4476
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03586
[Journal Article] Activation of Erk in ileal epithelial cells engaged in ischemic-injury repair2017
- Author(s)
  Takeda Haruna、Kiyokawa Etsuko
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41598-017-16714-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03586
[Journal Article] Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development2016
- Author(s)
  Haruna Takeda, Alistair G. Rust, Jerrold M. Ward, Christopher Chin Kuan Yew, Nancy A. Jenkins and Neal G. Copeland
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 113 Pages: 2057-2065
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21470
[Journal Article] トランスポゾン挿入変異を用いたがん形成に関与する遺伝子の同定2015
- Author(s)
  武田はるな
- Journal Title
  
  金沢医科大学雑誌
  
  Volume: 40 Pages: 54-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K21470
[Journal Article] Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression.2015
- Author(s)
  Takeda H, Wei Z, Koso H, Rust AG, Yew CC, Mann MB, Ward JM, Adams DJ, Copeland NG, Jenkins NA.
- Journal Title
  
  Nature Genetics
  
  Volume: 47 Issue: 2 Pages: 142-150
- DOI
  10.1038/ng.3175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860230, KAKENHI-PROJECT-26430108
[Presentation] 大腸炎症関連がんにおける細胞老化経路の関与2022
- Author(s)
  下村奏、服部奈緒子、飯田直子、加藤護、白石友一、武田はるな
- Organizer
  第81回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19421
[Presentation] SB トランスポゾンスクリーニングを用いた炎症関連がん形成に関与する遺伝子の網羅的同定2022
- Author(s)
  武田はるな、下村奏、飯田直子、服部奈緒子、加藤護、白石友一
- Organizer
  第81回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19421
[Presentation] Sleeping Beautyを用いた炎症関連がん遺伝子の網羅的同定2022
- Author(s)
  下村奏、服部奈緒子、飯田直子、加藤護、白石友一、武田はるな
- Organizer
  第35回発癌病理研究会
- Data Source
  KAKENHI-PROJECT-20H03522
[Presentation] SB トランスポゾンスクリーニングを用いた炎症関連がん形成に関与する遺伝子の網羅的同定2022
- Author(s)
  武田はるな、下村奏、飯田直子、服部奈緒子、加藤護、白石友一
- Organizer
  第81回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03522
[Presentation] 大腸炎症関連がんにおける細胞老化経路の関与2022
- Author(s)
  下村奏、服部奈緒子、飯田直子、加藤護、白石友一、武田はるな
- Organizer
  第81回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03522
[Presentation] SB トランスポゾンを用いた生体内スクリーニング2022
- Author(s)
  武田はるな
- Organizer
  第81回日本癌学会学術総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19421
[Presentation] Sleeping Beautyを用いた炎症関連がん遺伝子の網羅的同定2022
- Author(s)
  下村奏、服部奈緒子、飯田直子、加藤護、白石友一、武田はるな
- Organizer
  第35回発癌病理研究会
- Data Source
  KAKENHI-PROJECT-21K19421
[Presentation] SB トランスポゾンスクリーニングを用いた大腸がん転移に関わる遺伝子の同定2022
- Author(s)
  村中柚花理、飯田直子、服部奈緒子、加藤護、白石友一、武田はるな
- Organizer
  第81回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03522
[Presentation] SB トランスポゾンを用いた生体内スクリーニング2022
- Author(s)
  武田はるな
- Organizer
  第81回日本癌学会学術総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03522
[Presentation] SB トランスポゾンスクリーニングを用いた大腸がん転移に関わる遺伝子の同定2022
- Author(s)
  村中柚花理、飯田直子、服部奈緒子、加藤護、白石友一、武田はるな
- Organizer
  第81回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19421
[Presentation] Identification of colorectal cancer driver genes by Sleeping Beauty mutagenesis2021
- Author(s)
  Haruna Takeda
- Organizer
  The 39th Sapporo International Cancer Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03522
[Presentation] Sleeping Beauty トランスポゾンを用いた大腸がん転移モデルの樹立2021
- Author(s)
  武田はるな
- Organizer
  第80回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19421
[Presentation] Sleeping Beauty トランスポゾンを用いた大腸炎関連がん遺伝子の同定2021
- Author(s)
  下村奏、武田はるな
- Organizer
  第80回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19421
[Presentation] Sleeping Beauty トランスポゾンを用いた大腸炎関連がん遺伝子の同定2021
- Author(s)
  下村奏、武田はるな
- Organizer
  第80回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03522
[Presentation] Sleeping Beauty トランスポゾンを用いた大腸がん転移モデルの樹立2021
- Author(s)
  武田はるな
- Organizer
  第80回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03522
[Presentation] Identification of colorectal cancer driver genes by Sleeping Beauty mutagenesis2021
- Author(s)
  Haruna Takeda
- Organizer
  The 39th Sapporo International Cancer Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19421
[Presentation] マウス消化管腫瘍由来のオルガノイドとCRISPR-Cas9を用いたがん化能検証実験系の確立2019
- Author(s)
  武田はるな
- Organizer
  3.蛋白研セミナー, 大阪大学　微生物病研究所　谷口記念講堂
- Invited
- Data Source
  KAKENHI-PROJECT-17H03586
[Presentation] マウス消化管腫瘍由来のオルガノイドとCRISPR-Cas9を用いたがん化能検証実験系の確立2019
- Author(s)
  武田はるな
- Organizer
  第42回日本分子生物学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03586
[Presentation] CRISPR-Cas9-mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes2019
- Author(s)
  武田はるな
- Organizer
  2.Duke-NUS joint symposium, Kanazawa, Ishikawa, Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03586
[Presentation] Sleeping Beauty トランスポゾンを用いた大腸がん悪性化に関与する遺伝子の同定2019
- Author(s)
  武田はるな
- Organizer
  第一回日本医学会連合Rising Starリトリート
- Data Source
  KAKENHI-PROJECT-17H03586
[Presentation] CRISPR-Cas9 screening in organoids identified Acvr2a, Acvr1b and Arid2 as colorectal tumor suppressor genes2019
- Author(s)
  Haruna Takeda
- Organizer
  11th AACR-JCA Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03586
[Presentation] Sleeping Beautyトランスポゾンを用いた大腸がん形成に関与する遺伝子の同定2018
- Author(s)
  武田はるな
- Organizer
  第77回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03586
[Presentation] Sleeping Beauty (SB) トランスポゾンを用いた大腸がん形成に関与する遺伝子の同定2018
- Author(s)
  武田はるな
- Organizer
  第65回日本実験動物学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03586
[Presentation] Sleeping Beauty transposon mutagenesis identified genes involved in colorectal cancer progression2018
- Author(s)
  武田はるな
- Organizer
  国立遺伝学研究所国際シンポジウム 2018, Genome Editing and Functional Genomics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03586
[Presentation] Sleeping Beauty transposon mutagenesis identifies genes involved in colorectal cancer progression2018
- Author(s)
  Haruna Takeda
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03586
[Presentation] Sleeping beauty transposon identifies genes involved in colon cancer development2017
- Author(s)
  武田　はるな
- Organizer
  ALBERTA-JAPAN Agency For Medical Research And Development (AMED) Workshop For Medical Innovation
- Place of Presentation
  カルガリー・カナダ・ハイアットホテル
- Year and Date
  2017-02-24
- Data Source
  KAKENHI-PROJECT-15K21470
[Presentation] マウスモデルを用いた大腸がんドライバー遺伝子の同定と機能評価2017
- Author(s)
  武田はるな
- Organizer
  共同利用・共同研究拠点シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H03586
[Presentation] Identification of colorectal cancer driver genes2017
- Author(s)
  武田はるな
- Organizer
  XVIth KICancer & StratCan Retreat
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03586
[Presentation] Identification of driver genes promoting colorectal tumorigenesis2017
- Author(s)
  武田はるな
- Organizer
  第76回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03586
[Presentation] Sleeping Beauty (SB)トランスポゾンによる大腸がん形成に関与する遺伝子の同定2016
- Author(s)
  武田　はるな
- Organizer
  第2回AMEDがん若手研究者ワークショップ
- Place of Presentation
  東京・晴海グランドホテル
- Year and Date
  2016-11-29
- Data Source
  KAKENHI-PROJECT-15K21470
[Presentation] Sleeping Beauty (SB)トランスポゾンによる大腸がん形成に関与する遺伝子の同定2016
- Author(s)
  武田　はるな
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜・パシフィコ横浜
- Year and Date
  2016-10-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21470
[Presentation] Sleeping Beauty transposon mutagenesis identifies genes that cooperate with Smad4 loss in gastric cancer development2016
- Author(s)
  Haruna Takeda
- Organizer
  Breakthroughs in cancer research:from biology to therapeutics
- Place of Presentation
  Maui, Hawaii
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21470
[Presentation] Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression2015
- Author(s)
  武田はるな
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21470
[Presentation] SBトランスポゾン挿入変異を用いた、大腸がんの悪性化に関わる遺伝子のスクリーニング
- Author(s)
  武田はるな
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜　（神奈川県横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25860230

1. 大島正伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Takeda Haruna 武田 はるな

TAKEDA Haruna 武田 はるな

Research Projects

Research Products

Co-Researchers

Identification and validation of colitis associated cancer driver genes.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification and functional validation of novel therapeutic targets for colorectal cancer using forward genetic approaches in micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of colorectal cancer driver genes involved in cancer development and therapeutic resistance.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and validation of gastric cancer genesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the role of inflammation on gastric cancer formation using a mouse modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Characterization of RNF43 frameshift mutations that drive Wnt ligand‐ and R‐spondin‐dependent colon cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Platform for Validating Colorectal Cancer Driver Genes Using Mouse Organoids.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of cancer driver genes using Sleeping Beauty transposon mutagenesis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CRISPR-Cas9と消化管由来オルガノイドを用いた大腸がんドライバー遺伝子の機能検証2020

Author(s)

Journal Title

Data Source

[Journal Article] CRISPR-Cas9 mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia2017

Author(s)

Journal Title

Data Source

[Journal Article] Activation of Erk in ileal epithelial cells engaged in ischemic-injury repair2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development2016

Author(s)

Journal Title

Data Source

[Journal Article] トランスポゾン挿入変異を用いたがん形成に関与する遺伝子の同定2015

Author(s)

Journal Title

Takeda Haruna 武田はるな

TAKEDA Haruna 武田はるな