AKIMOTO JUN 秋元淳

… Alternative Names

AKIMOTO Jun 秋元淳

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Researcher Number	80649682
Affiliation (based on the past Project Information) *help	2019 – 2023: 国立研究開発法人理化学研究所, 創発物性科学研究センター, 研究員 2018: 国立研究開発法人理化学研究所, 開拓研究本部, 基礎科学特別研究員 2016: 国立研究開発法人理化学研究所, 伊藤ナノ医工学研究室, 基礎科学特別研究員 2015: 東京女子医科大学, 医学部, 助教 2014: 東京女子医科大学, 医学部, 博士研究員 2013: 東京女子医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 90120:Biomaterials-related / Biomedical engineering/Biomaterial science and engineering Except Principal Investigator Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 90110:Biomedical engineering-related / Biomedical engineering/Biomaterial science and engineering
Keywords	Principal Investigator 温度応答性 / ドラッグデリバリーシステム / in situ反応 / がん組織固定 / 反応制御 / 組織固定 / ナノ粒子 / がん治療 / 化学架橋ゲル / 刺激応答性 … More / ハイドロゲル / 刺激応答性材料 / 高分子ミセル / 小胞体ストレス … More Except Principal Investigator 癌治療 / 高分子医薬 / ペプチド医薬 / 進化分子工学 / 免疫チェックポイント阻害剤 / 抗癌剤 / がん治療 / 抗がん剤デリバリー / ドラッグ・デリバリー / 免疫治療 / 超分子集合体形成 / 両親媒性ポリペプチド / ナノキャリア / 低分子医薬 / 灌流培養 / 担癌モデル動物 / 腫瘍モデル / がん組織工学 / 過重力 / がん細胞 / 細胞パッチ / 中分子量医薬 / 金ナノ粒子 / 高分子化 / 多価リガンド化 / 低分子阻害剤 / PD-1 / 高分子効果 / 免疫療法 / Click反応 / 多価効果 / 中分子医薬 / バイオリアクター / バイオイメージング / 癌 / 薬剤反応性 / 薬剤応答性 / がんモデル / 組織工学 / 細胞シート / がん Less

Multimodal cancer therapy by combination of immune therapy and targeting nanostructured carrier containing anti-cancer drug
- Principal Investigator
  
  Ito Yoshihiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Institute of Physical and Chemical Research
Development of polymeric immune checkpoint inhibitor by extension of low molecular weight compound
- Principal Investigator
  
  Ito Yoshihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Institute of Physical and Chemical Research
Development of innovative human tumor models using cell patch method for high-speed three-dimensional organization
- Principal Investigator
  
  Nakayama Masamichi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Tokyo Women's Medical University
Development of tumor tissue fixation method by controlling chemical reaction between stimuli-responsive materials and biological moleculesPrincipal Investigator
- Principal Investigator
  
  AKIMOTO JUN
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Institute of Physical and Chemical Research
Development of cell apoptosis inducing smart nanoparticles by endoplasmic reticulum stressPrincipal Investigator
- Principal Investigator
  
  AKIMOTO JUN
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Institute of Physical and Chemical Research
  Tokyo Women's Medical University
Cancer cell sheet tissue engineering for development of innovative three-dimensional cancer tissue models
- Principal Investigator
  
  Nakayama Masamichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Tokyo Women's Medical University

All 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation Book

[Book] DDS研究30年　温故知新2015
- Author(s)
  中山正道, 秋元淳, 岡野光夫
- Total Pages
  6
- Publisher
  じほう
- Data Source
  KAKENHI-PROJECT-25282145
[Journal Article] Selective Control of Cell Activity with Hydrophilic Polymer‐Covered Cationic Nanoparticles2020
- Author(s)
  Lin Hsiu‐Pen、Akimoto Jun、Li Yaw‐Kuen、Ito Yoshihiro
- Journal Title
  
  Macromolecular Bioscience
  
  Volume: 20 Issue: 6 Pages: 2000049-2000049
- DOI
  10.1002/mabi.202000049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K12090
[Journal Article] Thermally Induced Switch of Coupling Reaction Using the Morphological Change of a Thermoresponsive Polymer on a Reactive Heteroarmed Nanoparticle2020
- Author(s)
  Park So Jung、Akimoto Jun、Sakakibara Naoki、Kobatake Eiry、Ito Yoshihiro
- Journal Title
  
  ACS Applied Materials & Interfaces
  
  Volume: 12 Issue: 43 Pages: 49165-49173
- DOI
  10.1021/acsami.0c12875
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K12090
[Journal Article] Reactivity Control of Polymer Functional Groups by Altering the Structure of Thermoresponsive Triblock Copolymers2019
- Author(s)
  Akimoto Jun、Tamate Ryota、Okazawa Shingo、Akimoto Aya M.、Onoda Michika、Yoshida Ryo、Ito Yoshihiro
- Journal Title
  
  ACS Omega
  
  Volume: 4 Issue: 15 Pages: 16344-16351
- DOI
  10.1021/acsomega.9b01816
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K12090, KAKENHI-PROJECT-19J00458, KAKENHI-PROJECT-18K14280
[Journal Article] Controlling the electrostatic interaction using a thermal signal to structurally change thermoresponsive nanoparticles2019
- Author(s)
  Akimoto Jun、Lin Hsiu-Pen、Li Yaw-Kuen、Ito Yoshihiro
- Journal Title
  
  Colloids and Surfaces A: Physicochemical and Engineering Aspects
  
  Volume: 577 Pages: 27-33
- DOI
  10.1016/j.colsurfa.2019.05.052
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K12090
[Journal Article] 生体に学ぶ3次元がん組織モデルへのアプローチ2015
- Author(s)
  秋元淳, 中山正道, 岡野光夫
- Journal Title
  
  バイオマテリアル
  
  Volume: 33 Pages: 236-245
- Data Source
  KAKENHI-PROJECT-25282145
[Journal Article] Temperature-responsive polymeric micelles for optimizing drug targeting to solid tumors2014
- Author(s)
  Akimoto Jun, Nakayama Masamichi, Okano Teruo
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 193 Pages: 2-8
- DOI
  10.1016/j.jconrel.2014.06.062
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25282145
[Journal Article] Polymeric micelles with stimuli-triggering systems for advanced cancer drug targeting2014
- Author(s)
  Nakayama Masamichi, Akimoto Jun, Okano Teruo
- Journal Title
  
  Journal of Drug Targeting
  
  Volume: 22 Issue: 7 Pages: 584-599
- DOI
  10.3109/1061186x.2014.936872
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25282145
[Journal Article] Facile cell sheet manipulation and transplantation by using in situ gelation method2014
- Author(s)
  Akimoto Jun, Arauchi Ayumi, Nakayama Masamichi, Kanaya Ryo, Iwase Yuko, Takagi Soichi , Yamato Masayuki, Okano Teruo
- Journal Title
  
  Journal of Biomedical Materials Research Part B: Applied Biomaterials
  
  Volume: 102B Issue: 8 Pages: 1659-1668
- DOI
  10.1002/jbm.b.33148
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25282145
[Presentation] Thermally controlled gelation by morphological change of temperature responsive polymer on hetero-armed nanoparticle2020
- Author(s)
  Park, S. J., Akimoto, J., Kobatake, E., Ito, Y.
- Organizer
  3rd GLowing Polymer Symposium in KANTO
- Data Source
  KAKENHI-PROJECT-18K12090
[Presentation] 化学反応性の制御可能な温度応答性ナノ粒子を利用したインジェクタブルゲルの開発2020
- Author(s)
  秋元淳、Park So Jung、小畠英理、伊藤嘉浩
- Organizer
  第36回日本DDS学会
- Data Source
  KAKENHI-PROJECT-18K12090
[Presentation] Transplantation of sheet-like cancer cell tissues for orthotopic tumor-bearing animal models2020
- Author(s)
  Nakayama Masamichi、Akimoto Jun、Okano Teruo
- Organizer
  47th Annual Meeting of the Controlled Release Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04454
[Presentation] Irreversible hydrogel formation by coupling reaction control using structural change of thermo-responsive hetero-armed nanoparticle2019
- Author(s)
  So Jung Park, Jun Akimoto, Eiry Kobatake, Yoshihiro Ito
- Organizer
  CEMSupra 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K12090
[Presentation] 電荷高分子導入による温度応答性高分子ミセルの分散安定性評価2018
- Author(s)
  秋元淳・Hsiu-Pen Lin・Yaw-Kuen Li・伊藤嘉浩
- Organizer
  第67回高分子討論会
- Data Source
  KAKENHI-PROJECT-18K12090
[Presentation] チオール基反応性化合物内包ナノ粒子の細胞内導入による細胞死誘導システムの構築2017
- Author(s)
  秋元淳，中山正道，岡野光夫，伊藤嘉浩
- Organizer
  つくば医工連携フォーラム 2017
- Place of Presentation
  国立研究開発法人物質・材料研究機構（茨城県つくば市）
- Data Source
  KAKENHI-PROJECT-26750160
[Presentation] Controlled phase transition behaviors of thermoresponsive polymeric micelles by in-troducing hydrophilic chain in their corona2016
- Author(s)
  秋元淳、中山正道、岡野光夫
- Organizer
  The 2nd Int'l Conference on Polymer Materials Science
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2016-01-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26750160
[Presentation] Effective Fabrication of Tumor-bearing Animal Models by Cancer Cell Sheet Transplantation2015
- Author(s)
  Masamichi Nakayama, Jun Akimoto, Masayuki Yamato, Teruo Okano
- Organizer
  The 42nd CRS Annual Meeting & Exposition
- Place of Presentation
  エジンバラ（スコットランド）
- Year and Date
  2015-07-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25282145

1. Nakayama Masamichi (00338980)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. Ito Yoshihiro (40192497)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. NAGASE Kenichi (10439838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. IWASE YUKO (80406371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 宮武秀行 (50291935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 増田信奈子 (30342851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 関根秀一 (60541737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 原口裕次 (80272251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 上田一樹 (10615040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 鵜澤尊規 (60554376)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 松川昭博 (90264283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KANNO Tomonori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TOYOSHIMA Yuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

AKIMOTO JUN 秋元 淳

AKIMOTO Jun 秋元 淳

Research Projects

Research Products

Co-Researchers

Multimodal cancer therapy by combination of immune therapy and targeting nanostructured carrier containing anti-cancer drug

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of polymeric immune checkpoint inhibitor by extension of low molecular weight compound

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of innovative human tumor models using cell patch method for high-speed three-dimensional organization

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of tumor tissue fixation method by controlling chemical reaction between stimuli-responsive materials and biological moleculesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of cell apoptosis inducing smart nanoparticles by endoplasmic reticulum stressPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cancer cell sheet tissue engineering for development of innovative three-dimensional cancer tissue models

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] DDS研究30年 温故知新2015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Selective Control of Cell Activity with Hydrophilic Polymer‐Covered Cationic Nanoparticles2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Thermally Induced Switch of Coupling Reaction Using the Morphological Change of a Thermoresponsive Polymer on a Reactive Heteroarmed Nanoparticle2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reactivity Control of Polymer Functional Groups by Altering the Structure of Thermoresponsive Triblock Copolymers2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Controlling the electrostatic interaction using a thermal signal to structurally change thermoresponsive nanoparticles2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 生体に学ぶ3次元がん組織モデルへのアプローチ2015

Author(s)

Journal Title

Data Source

[Journal Article] Temperature-responsive polymeric micelles for optimizing drug targeting to solid tumors2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polymeric micelles with stimuli-triggering systems for advanced cancer drug targeting2014

Author(s)

Journal Title

DOI

Data Source

AKIMOTO JUN 秋元淳

AKIMOTO Jun 秋元淳

[Book] DDS研究30年　温故知新2015