IZAWA KUMI 伊沢久未

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IZAWA Kumi 伊沢久未

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Researcher Number	80708313
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 特任准教授
Affiliation (based on the past Project Information) *help	2022: 順天堂大学, 大学院医学研究科, 特任准教授 2021: 順天堂大学, 大学院医学研究科, 助教 2015 – 2020: 順天堂大学, 医学(系)研究科(研究院), 助教 2013 – 2014: 東京大学, 医科学研究所, 助教
Review Section/Research Field	Principal Investigator Dermatology / Basic Section 53050:Dermatology-related / Collagenous pathology/Allergology
Keywords	Principal Investigator CD300 / ペア型レセプター / セラミド / アレルギー / 自己免疫性表皮下水疱症 / 天疱瘡 / 自己免疫性水疱症 / 抑制型免疫受容体 / 免疫複合体 / 好中球 … More / 抑制型受容体 / zymosan / ceramide / LPS / TLR / 好塩基球 / 免疫学 / スフィンゴミエリン / IgE / マスト細胞 Less

Elucidation of the mechanisms by which an inhibitory receptor regulates the development of autoimmune subepidermal bullous diseasesPrincipal Investigator
- Principal Investigator
  
  Izawa Kumi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Juntendo University
Elucidation of control mechanism of skin inflammatory diseases involving TLRsPrincipal Investigator
- Principal Investigator
  
  Izawa Kumi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Juntendo University
Functional analysis of an inhibitory receptor LMIR3 in basophil activation and Th2-type immune responsesPrincipal Investigator
- Principal Investigator
  
  Izawa Kumi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Juntendo University
Functional analysis of human LMIR3/CD300FPrincipal Investigator
- Principal Investigator
  
  IZAWA Kumi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013

All Journal Article Presentation Book Patent

[Book] 炎症と免疫2014
- Author(s)
  北浦次郎、伊沢久未、北村俊雄
- Total Pages
  4
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-25893050
[Book] 臨床免疫・アレルギー科2013
- Author(s)
  北浦次郎、伊沢久未、北村俊雄
- Total Pages
  8
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-25893050
[Book] 生化学2013
- Author(s)
  北浦次郎、伊沢久未、北村俊雄
- Total Pages
  5
- Publisher
  日本生化学会
- Data Source
  KAKENHI-PROJECT-25893050
[Book] 臨床免疫・アレルギー科2013
- Author(s)
  北浦次郎、伊沢久未、山西吉典、北村俊雄
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-25893050
[Journal Article] The protective role of conjunctival goblet cell mucin sialylation2023
- Author(s)
  Matsuzawa M, Ando T, Fukase S, Kimura M, Kume Y, Ide T, Izawa K, Kaitani A, Hara M, Nakamura E, Kamei A, Matsuda A, Nakano N, Maeda K, Tada N, Ogawa H, Okumura K, Murakami A, Ebihara N, Kitaura J.
- Journal Title
  
  Nat Commun
  
  Volume: 14 Issue: 1 Pages: 1417-1417
- DOI
  10.1038/s41467-023-37101-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K11887, KAKENHI-PROJECT-20H03721, KAKENHI-PROJECT-17K10253, KAKENHI-PROJECT-19K08782, KAKENHI-PROJECT-19K09980, KAKENHI-PROJECT-22K09819
[Journal Article] Mucosal Mast Cell-Specific Gene Expression Is Promoted by Interdependent Action of Notch and TGF-β Signaling.2022
- Author(s)
  Nakano N, Saida K, Hara M, Izawa K, Ando T, Kaitani A, Kasakura K, Yashiro T, Nishiyama C, Ogawa H, Kitaura J, Okumura K.
- Journal Title
  
  J Immunol.
  
  Volume: - Issue: 12 Pages: 3098-3106
- DOI
  10.4049/jimmunol.2100112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03721, KAKENHI-PROJECT-17K10253, KAKENHI-PROJECT-19K08782, KAKENHI-PROJECT-20K08808, KAKENHI-PROJECT-19K17818, KAKENHI-PROJECT-20H02939
[Journal Article] Development of mouse model for oral allergy syndrome to identify IgE cross-reactive pollen and food allergens: ragweed pollen cross-reacts with fennel and black pepper2022
- Author(s)
  Kamei Anna、Izawa Kumi、Ando Tomoaki、Kaitani Ayako、Yamamoto Risa、Maehara Akie、Ide Takuma、Yamada Hiromichi、Kojima Mayuki、Wang Hexing、Tokushige Koji、Nakano Nobuhiro、Shimizu Toshiaki、Ogawa Hideoki、Okumura Ko、Kitaura Jiro
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 945222-945222
- DOI
  10.3389/fimmu.2022.945222
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08550, KAKENHI-PROJECT-22K11887, KAKENHI-PROJECT-20H03721, KAKENHI-PROJECT-19K08782, KAKENHI-PROJECT-20K08808
[Journal Article] ペア型免疫受容体とアレルギー疾患2022
- Author(s)
  北浦次郎、伊沢久未、貝谷綾子
- Journal Title
  
  アレルギーの臨床
  
  Volume: 42 Pages: 15-19
- Data Source
  KAKENHI-PROJECT-19K08782
[Journal Article] A possible association between a novel NLRP1 mutation and an autoinflammatory disease involving liver cirrhosis2021
- Author(s)
  Yasudo Hiroki、Ando Taiki、Maehara Akie、Ando Tomoaki、Izawa Kumi、Tanabe Atsushi、Kaitani Ayako、Nomura Shigeru、Seki Masafumi、Yoshida Kenichi、Oda Hirotsugu、Okamoto Yoko、Wang Hexing、Kamei Anna、Kojima Mayuki、Kimura Meiko、Uchida Koichiro、Nakano Nobuhiro、Kaneko Junichi、et al.
- Journal Title
  
  Hepatology
  
  Volume: - Issue: 4 Pages: 2296-2299
- DOI
  10.1002/hep.31818
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10253, KAKENHI-PROJECT-19K08782, KAKENHI-PROJECT-20K08808, KAKENHI-PROJECT-19K17818, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-20H03721, KAKENHI-PROJECT-18K08416, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-21K19405, KAKENHI-PROJECT-21K20912
[Journal Article] Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy.2021
- Author(s)
  Takasato Y, Kurashima Y, Kiuchi M, Hirahara K, Murasaki S, Arai F, Izawa K, Kaitani A, Shimada k, Saito Y, Toyoshima S, Nakamura M, Fujisawa K, Okayama Y, Kunisawa J, Kubo M, Takemura N, Uematsu S, Akira S, Kitaura J, Takahashi T, Nakayama T, Kiyono H
- Journal Title
  
  Mucosal Immunol
  
  Volume: 14 Issue: 3 Pages: 640-651
- DOI
  10.1038/s41385-020-00358-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08782, KAKENHI-PROJECT-19K16683, KAKENHI-PROJECT-19K17818, KAKENHI-PROJECT-18H02571, KAKENHI-PROJECT-19H03450, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-20H03721, KAKENHI-PROJECT-19K22634, KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-18H05280, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-21K19083, KAKENHI-PROJECT-21K19495, KAKENHI-PROJECT-18KK0432
[Journal Article] Pollen shells and soluble factors play non-redundant roles in the development of allergic conjunctivitis in mice2021
- Author(s)
  Fukase S, Ando T, Matsuzawa M, Kimura M, Sone Y, Izawa K, Kaitani A, Kamei A, Kojima M, Nakano N, Maeda K, Shimizu T, Ogawa H, Okumura K, Nishiyama N, Murakami A, Ebihara N, Kitaura J.
- Journal Title
  
  Ocul Surf.
  
  Volume: 22 Pages: 153-162
- DOI
  10.1016/j.jtos.2021.08.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03721, KAKENHI-PROJECT-17K10253, KAKENHI-PROJECT-19K08782, KAKENHI-PROJECT-20K08808, KAKENHI-PROJECT-19K17818
[Journal Article] CD300f分子とアレルギー（解説）2021
- Author(s)
  貝谷綾子、伊沢久未、内田志野、亀井杏菜、前原明絵、安藤智暁、北浦次郎
- Journal Title
  
  科学評論社、臨床免疫・アレルギー科
  
  Volume: 75 Pages: 218-225
- Data Source
  KAKENHI-PROJECT-19K08782
[Journal Article] アレルギー疾患と抑制化受容体(特集:抑制化受容体と免疫応答)2021
- Author(s)
  伊沢久未、貝谷綾子、北浦次郎
- Journal Title
  
  先端医学社、炎症と免疫
  
  Volume: 29 Pages: 13-18
- Data Source
  KAKENHI-PROJECT-19K08782
[Journal Article] Notch signaling contributes to the establishment of sustained unresponsiveness to food allergens by oral immunotherapy2021
- Author(s)
  Yoneyama Toshiyuki、Nakano Nobuhiro、Hara Mutsuko、Yamada Hiromichi、Izawa Kumi、Uchida Koichiro、Kaitani Ayako、Ando Tomoaki、Kitaura Jiro、Ohtsuka Yoshikazu、Ogawa Hideoki、Okumura Ko、Shimizu Toshiaki
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 147 Issue: 3 Pages: 1063-1076
- DOI
  10.1016/j.jaci.2020.07.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10253, KAKENHI-PROJECT-19K08782, KAKENHI-PROJECT-20K08808, KAKENHI-PROJECT-19K17818, KAKENHI-PROJECT-20H03721, KAKENHI-PROJECT-18K08416
[Journal Article] CD300fは食物アレルギーの治療標的となりうる2020
- Author(s)
  内田志野、伊沢久未、安藤智暁、貝谷綾子、北浦次郎
- Journal Title
  
  科学評論社、臨床免疫・アレルギー科
  
  Volume: 74 Pages: 398-405
- Data Source
  KAKENHI-PROJECT-19K08782
[Journal Article] Differential lipid recognition by mouse versus human CD300f, inhibiting passive cutaneous anaphylaxis, depends on a single amino acid substitution in its immunoglobulin-like domain.2020
- Author(s)
  Izawa K, Kaitani A, Ando T, Maehara A, Nagamine M, Yamada H, Ando T, Ide T, Matsuzawa M, Okamoto Y, Yin E, Fukase S, Wang H, Kamei A, Uchida S, Keiko M, Nakano N, Uchida K, Tamura N, Ikeda K, Ebihara N, Shimizu T, Voehringer D, Roers A, Ogawa H, Okumura K, Kitaura J
- Journal Title
  
  J Invest Dermatol.
  
  Volume: 140 Pages: 710-713
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08782
[Journal Article] Receptor-destroying enzyme (RDE) from Vibrio cholerae modulates IgE activity and reduces the initiation of anaphylaxis2019
- Author(s)
  Yamazaki Tatsuya、Inui Masanori、Hiemori Keiko、Tomono Susumu、Itoh Makoto、Ichimonji Isao、Nakashima Akina、Takagi Hidekazu、Biswas Mrityunjoy、Izawa Kumi、Kitaura Jiro、Imai Teruko、Sugiura Nobuo、Tateno Hiroaki、Akashi-Takamura Sachiko
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 17 Pages: 6659-6669
- DOI
  10.1074/jbc.ra118.006375
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08874, KAKENHI-PROJECT-17H04217, KAKENHI-PROJECT-16H05898, KAKENHI-PROJECT-17K07352, KAKENHI-PROJECT-19K08500, KAKENHI-PROJECT-19K08782
[Journal Article] Identification of inhibitory mechanisms in pseudo-allergy involving Mrgprb2/MRGPRX2-mediated mast cell activation2019
- Author(s)
  Takamori A, Ozawa K, Kaitani A, Ando T, Okamoto Y, Maehara A, Tanabe A, Nagamine M, Yamada H, Uchida S, Uchida K, Isobe M, Hatayama T, Watanabe D, Ando T, Ide T, Matsuzawa M, Maeda K, Nakano N, Tamura N, Ikeda K, Ebihara N, Shimizu T, Ogawa H, Okumura K, Kitaura J
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 143 Issue: 3 Pages: 1231-1235
- DOI
  10.1016/j.jaci.2018.10.034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08416, KAKENHI-PUBLICLY-17H05515, KAKENHI-PROJECT-17H04217, KAKENHI-PROJECT-17H04348, KAKENHI-PROJECT-17K16352
[Journal Article] CD300f is a potential therapeutic target for the treatment of food allergy2019
- Author(s)
  Uchida Shino、Izawa Kumi、Ando Tomoaki、Yamada Hiromichi、Uchida Koichiro、Negishi Naoko、Kaitani Ayako、Maehara Akie、Nagamine Masakazu、Kamei Anna、Takamori Ayako、Maeda Keiko、Nakano Nobuhiro、Shimizu Toshiaki、Ogawa Hideoki、Okumura Ko、Nagahara Akihito、Watanabe Sumio、Kitaura Jiro
- Journal Title
  
  Allergy
  
  Volume: 75 Issue: 2 Pages: 471-474
- DOI
  10.1111/all.14034
- NAID
  40022209298
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10253, KAKENHI-PROJECT-18K08416, KAKENHI-PROJECT-19K08782, KAKENHI-PROJECT-19K17818, KAKENHI-PROJECT-19K17895, KAKENHI-PROJECT-17H04217, KAKENHI-PROJECT-19K18041
[Journal Article] The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide?dependent neutrophil recruitment2019
- Author(s)
  Takahashi Mariko、Izawa Kumi、Urai Makoto、Yamanishi Yoshinori、Maehara Akie、Isobe Masamichi、Matsukawa Toshihiro、Kaitani Ayako、Takamori Ayako、Uchida Shino、Yamada Hiromichi、Nagamine Masakazu、Ando Tomoaki、Shimizu Toshiaki、Ogawa Hideoki、Okumura Ko、Kinjo Yuki、Kitamura Toshio、Kitaura Jiro
- Journal Title
  
  Science Signaling
  
  Volume: 12 Issue: 564 Pages: 564-564
- DOI
  10.1126/scisignal.aar5514
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19529, KAKENHI-PUBLICLY-17H05515, KAKENHI-PROJECT-17H04217, KAKENHI-PROJECT-17K16352, KAKENHI-PROJECT-19K17818
[Journal Article] セラミドと皮膚アレルギー・炎症2018
- Author(s)
  貝谷綾子、前原明絵、高森綾子、伊沢久未、北浦次郎
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 69 Pages: 576-582
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16352
[Journal Article] The CD300e molecule in mice is an immune-activating receptor.2018
- Author(s)
  Isobe M, Izawa K, Sugiuchi M, Sakanishi T, Kaitani A, Takamori A, Maehara A, Matsukawa T, Takahashi M, Yamanishi Y, Oki T, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Yagita H, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J.
- Journal Title
  
  J Biol Chem.
  
  Volume: 293 Issue: 10 Pages: 3793-3805
- DOI
  10.1074/jbc.ra117.000696
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16352, KAKENHI-PROJECT-15K09784, KAKENHI-PROJECT-15K20969, KAKENHI-PUBLICLY-17H05515, KAKENHI-PROJECT-17H04217
[Journal Article] Role of the ceramide-CD300f interaction in gram-negative bacterial skin infections.2018
- Author(s)
  Maehara A, Kaitani A, Izawa K, Shiba E, Nagamine M, Takamori A, Isobe M, Uchida S, Uchida K, Ando T, Keiko M, Nakano N, Voehringer D, Roers A, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J.
- Journal Title
  
  J Invest Dermatol.
  
  Volume: 138 Issue: 5 Pages: 1221-1224
- DOI
  10.1016/j.jid.2017.11.025
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16352, KAKENHI-PROJECT-15K09784, KAKENHI-PUBLICLY-17H05515, KAKENHI-PROJECT-17H04217
[Journal Article] 敗血症性腹膜炎におけるCD300fとセラミドの役割2018
- Author(s)
  伊沢久未、前原明絵、貝谷綾子、高森綾子、北浦次郎
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 69:3 Pages: 250-256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16352
[Journal Article] Mouse LIMR3/CD300f is a negative regulator of the antimicrobial activity of neutrophils2018
- Author(s)
  Ueno Keigo、Urai Makoto、Izawa Kumi、Otani Yoshiko、Yanagihara Nao、Kataoka Michiyo、Takatsuka Shogo、Abe Masahiro、Hasegawa Hideki、Shimizu Kiminori、Kitamura Toshio、Kitaura Jiro、Miyazaki Yoshitsugu、Kinjo Yuki
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 17406-17406
- DOI
  10.1038/s41598-018-35699-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19529, KAKENHI-PROJECT-17K18385, KAKENHI-PROJECT-17H04217, KAKENHI-PROJECT-17K16352
[Journal Article] Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 is an FcRγ-coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic cells2018
- Author(s)
  Kaitani A, Izawa K, Maehara A, Isobe M, Takamori A, Matsukawa T, Takahashi M, Yamanishi Y, Oki T, Yamada H, Nagamine M, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Shimizu T, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 8259-8259
- DOI
  10.1038/s41598-018-25646-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08416, KAKENHI-PUBLICLY-17H05515, KAKENHI-PROJECT-17H04217, KAKENHI-PROJECT-17K16352
[Journal Article] Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment.2017
- Author(s)
  Izawa K, Maehara A, Isobe M, Yasuda Y, Urai M, Hoshino Y, Ueno K, Matsukawa T, Takahashi M, Kaitani A, Shiba E, Takamori A, Uchida S, Uchida K, Maeda K, Nakano N, Yamanishi Y, Oki T, Voehringer D, Roers A, Nakae S, Ishikawa J, Kinjo Y, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J
- Journal Title
  
  Sci Rep.
  
  Volume: 7(1) Issue: 1 Pages: 4298-4298
- DOI
  10.1038/s41598-017-04647-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16352, KAKENHI-PROJECT-17K18385, KAKENHI-PROJECT-16H05349, KAKENHI-PROJECT-15K09784, KAKENHI-PROJECT-15K20969, KAKENHI-PUBLICLY-17H05515, KAKENHI-PROJECT-17H04217
[Journal Article] Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation.2017
- Author(s)
  Shiba E, Izawa K, Kaitani A, Isobe M, Maehara A, Uchida K, Maeda K, Nakano N, Ogawa H, Okumura K, Kitamura T, Shimizu T, Kitaura J
- Journal Title
  
  J Biol Chem.
  
  Volume: 292 Issue: 7 Pages: 2924-2932
- DOI
  10.1074/jbc.m116.768366
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293231, KAKENHI-PROJECT-15K15376, KAKENHI-PROJECT-15K19677, KAKENHI-PROJECT-15K09784
[Journal Article] Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation.2015
- Author(s)
  Matsukawa T, Izawa K, Isobe M, Takahashi M, Maehara A, Yamanishi Y, Kaitani A, Okumura K, Teshima T, Kitamura T, Kitaura J
- Journal Title
  
  Gut
  
  Volume: 印刷中 Issue: 5 Pages: 1-11
- DOI
  10.1136/gutjnl-2014-308900
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J00014, KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-25893050, KAKENHI-PROJECT-26293231, KAKENHI-PROJECT-26893063, KAKENHI-PROJECT-15K15376, KAKENHI-PROJECT-15K19677, KAKENHI-PROJECT-15K20969
[Journal Article] Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FceRI-mediated mast cell activation.2014
- Author(s)
  Izawa, K., Isobe, M., Matsukawa, T., Ito, S., Maehara, A., Takahashi, M., Yamanishi, Y., Kaitani, A., Oki, T., Okumura, K., *Kitamura, T., and *Kitaura, J.
- Journal Title
  
  J. Allergy. Clin. Immunol.
  
  Volume: 133 Issue: 1 Pages: 270-273
- DOI
  10.1016/j.jaci.2013.08.008
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-23390257, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-25893050, KAKENHI-PROJECT-26293087
[Patent] ヒトCD300fアゴニストのスクリーニング方法2021
- Inventor(s)
  北浦次郎、伊沢久未、安藤智暁
- Industrial Property Rights Holder
  順天堂大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-141305
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19K08782
[Patent] セラミドリポソームの製造法2021
- Inventor(s)
  北浦次郎、伊沢久未、安藤智暁、井出拓磨
- Industrial Property Rights Holder
  順天堂大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-185887
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] 希少疾患患者から同定されたNLRP1点変異（P1214L）は自己炎症性疾患を誘導する2023
- Author(s)
  安東泰希、前原明絵、安戸裕貴、伊沢久未、安藤智暁、貝谷綾子、田村直人、北浦次郎
- Organizer
  第6回日本免疫不全・自己炎症学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] NLRP1変異による自己炎症性疾患の病態2023
- Author(s)
  北浦次郎、安東泰希、前原明絵、安戸裕貴、山本里彩、伊沢久未、安藤智暁、貝谷綾子、田村直人
- Organizer
  第6回日本免疫不全・自己炎症学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] 結膜における杯細胞ムチンのシアル化が果たす保護的な役割2023
- Author(s)
  安藤智暁、松澤萌、深瀬紗綾、木村芽以子、久米泰治、伊沢久未、貝谷綾子、海老原伸行、北浦次郎
- Organizer
  第31回東京免疫フォーラム
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] マウスモデルによる口腔アレルギー症候群における交差抗原の同定法2022
- Author(s)
  亀井杏奈、伊沢久未、安藤智暁、貝谷綾子、前原明絵、王合興、徳重宏二、久米泰治、中野信浩、奥村康、北浦次郎
- Organizer
  第71回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] シグナル伝達機序に基づくIL-33/ST2シグナル抑制分子の作製2022
- Author(s)
  山本里彩、安藤智暁、貝谷綾子、伊沢久未、前原明絵、北浦次郎
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] セラミドリポソームの鼻腔投与は抑制型受容体CD300fを標的としてマウスモデルのアレルギー性鼻炎を抑える2022
- Author(s)
  貝谷綾子、井出琢磨、伊沢久未、北浦次郎
- Organizer
  第15回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] NLRP1-P1214L点変異はNLRP1とdipeptidyl peptidase 9（DPP9）の結合を阻害することによりNLRP1インフラマソームの活性化を亢進させる2022
- Author(s)
  山本里彩、前原明絵、安東泰希、安戸裕貴、伊沢久未、安藤智暁、貝谷綾子、奥村康、小川誠司、田村直人、北浦次郎
- Organizer
  第27回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] シアル化ムチンのヒト杯細胞における発現の変化とアレルゲン粒子からの保護作用2022
- Author(s)
  松澤萌, 安藤智暁, 深瀬紗綾, 木村芽以子,久米泰治，伊沢久未, 貝谷綾子, 中野信浩, 前田啓子, 奥村康, 松田彰, 村上晶, 海老原伸行, 北浦次郎
- Organizer
  第71回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] セラミドリポソームの経鼻投与は抑制型受容体CD300fを標的としてアレルギー性鼻炎を抑える2022
- Author(s)
  伊沢久未、井出拓磨、貝谷綾子、前原明絵、安藤智暁、北浦次郎
- Organizer
  第50回日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] 花粉-食物アレルギー症候群のマウスモデルとタンパク質アレイの解析による交差アレルゲンの同定2022
- Author(s)
  山本里彩、亀井杏菜、伊沢久未、安藤智暁、山田啓迪、小嶋まゆき、貝谷綾子、中野信浩、清水俊明、北浦次郎
- Organizer
  第59回日本小児アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] ヒトNLRP1の点変異が肝臓の繊維化を伴う自己炎症性疾患を誘導した2022
- Author(s)
  安東泰希、前原明絵、安戸裕貴、安藤智暁、伊沢久未、田辺篤、貝谷綾子、亀井杏菜、金子順一、山路健、奥村康、小川誠司、田村直人、北浦次郎
- Organizer
  第66回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] 皮膚の黄色ブドウ球菌デルタトキシンは経皮感作による食物アレルギーの発症を促進する2022
- Author(s)
  山田啓迪、亀井杏菜、貝谷綾子、小嶋まゆき、米山俊之、田中裕子、山崎晋、稲毛英介、馬場洋介、前原明絵、安藤智暁、伊沢久未、工藤孝広、大塚宜一、北浦次郎、清水俊明
- Organizer
  第59回日本小児アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Pollen shells promote allergic conjunctivitis through inducible goblet cell-associated antigen passage2022
- Author(s)
  Meiko Kimura, Tomoaki Ando, Saaya Fukase, Yasuharu Kume, Moe Matsuzawa, Kumi Izawa, Ayako Kaitani, Nobuhiro Nakano, Ko Okumura, Akira Murakami, Nobuyuki Ebihara, Jiro Kitaura
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Development of a murine model for oral allergy syndrome to identify IgE cross-reactive pollen and food allergens2022
- Author(s)
  Risa Yamamoto,　Anna Kamei, Kumi Izawa, Tomoaki Ando, Ayako Kaitani,　Akie Maehara, Yasuharu Kume, Hexing Wang, Koji Tokushige, Nobuhiro Nakano, Ko Okumura,　Jiro Kitaura
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] 肝臓繊維化を伴う希少疾患患者から同定されたNLRP1点変異はインフラマソームを強く活性化する2022
- Author(s)
  安東泰希、前原明絵、安戸裕貴、伊沢久未、安藤智暁、貝谷綾子、山路健、奥村康、小川誠司、田村直人、北浦次郎
- Organizer
  第43回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Fab fragments against human IgE Cε2 inhibit the binding of IgE to its receptors2022
- Author(s)
  Hexing Wang, Tomoaki Ando, Toshiaki Maruyama, CJ Okumura, Kumi Izawa, Ayako Kaitani, Yasuharu Kume, Koji Tokushige, Nobuhiro Nakano, Keiko Maeda, Ko Okumura, Jiro Kitaura
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Intranasal administration of ceramide liposomes inhibits ragweed pollen-induced allergic rhinitis by targeting CD300f2022
- Author(s)
  Ayako Kaitani,　Takuma Ide, Kumi Izawa, Tomoaki Ando, Akie Maehara, Risa Yamamoto, Yasuharu Kume, Hexing Wang, Koji Tokushige, Nobuhiro Nakano, Ko Okumura,　Jiro Kitaura
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] 結膜杯細胞におけるシアル化ムチンが示す保護作用2022
- Author(s)
  安藤智暁、松澤萌、深瀬紗綾、木村芽以子、久米泰治、伊沢久未、前原明絵、奥村康、松田彰、村上晶、海老原伸行、北浦次郎
- Organizer
  アレルギー・好酸球研究会 2022
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] The protective function of conjunctival goblet cell mucin sialylation2022
- Author(s)
  Tomoaki Ando, Moe Matsuzawa,Yasuharu Kume, Saaya Fukase, Meiko Kimura, Kumi Izawa, Ayako Kaitani, Ko Okumura, Akira Matsuda, Akira Murakami, Nobuyuki Ebihara, Jiro Kitaura
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] The effects of an antibody Fab library against human IgE Cε2 on the binding of IgE to its receptors2022
- Author(s)
  Hexing Wang, Tomoaki Ando, Toshiaki Maruyama, CJ Okumura, Kumi Izawa, Ayako Kaitani, Nobuhiro Nakano, Keiko Maeda, Ko Okumura, Jiro Kitaura
- Organizer
  第71回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] アレルギー性結膜炎発症における花粉の殻刺激によるGAP形成の役割2022
- Author(s)
  木村芽以子, 安藤智暁, 深瀬紗綾, 松澤萌, 久米泰治, 伊沢久未, 貝谷綾子, 亀井杏奈, 前田啓子, 奥村康, 村上晶, 北浦次郎, 海老原伸行
- Organizer
  第126回眼科学会総会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] 肝硬変を伴う希少疾患患者から同定されたNLRP1点変異の機能解明2022
- Author(s)
  前原明絵、安東泰希、安戸裕貴、伊沢久未、安藤智暁、貝谷綾子、奥村康、小川誠司、田村直人、北浦次郎
- Organizer
  第30回東京免疫フォーラム
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] 花粉点眼により誘導されるgoblet cell-associated antigen passage(GAP)の局在と粒子選択性2022
- Author(s)
  木村芽以子、安藤智暁、久米泰治、松澤萌、深瀬紗綾、伊沢久未、前原明絵、中野信浩、奥村康、村上晶、北浦次郎、海老原伸行
- Organizer
  第5回日本眼科アレルギー学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] セラミドリポソームの点鼻は抑制型受容体CD300fを標的としてアレルギー性鼻炎を抑える2022
- Author(s)
  井出拓磨、伊沢久未、亀井杏奈、貝谷綾子、前原明絵、安藤智暁、王合興、徳重宏二、久米泰治、中野信浩、奥村康、北浦次郎
- Organizer
  第71回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] ヒトNLRP1のFIINDにおける点変異（P1214L）は自己炎症性疾患を誘導する2022
- Author(s)
  前原明絵、安東泰希、安戸裕貴、伊沢久未、安藤智暁、貝谷綾子、田村直人、北浦次郎
- Organizer
  第5回日本免疫不全・自己炎症学会　総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] IL-33/ST2シグナルを抑制する分子の探索：IL-1RAcPとST2の細胞外領域とIgGのFc領域を結合させた融合タンパク質（IL-33trap-Fc）はIL-33シグナルを強く抑制する2022
- Author(s)
  山本里彩、安藤智暁、貝谷綾子、伊沢久未、前原明絵、北浦次郎
- Organizer
  第146回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Pollen shells promote development of allergic conjunctivitis through inducible goblet cell-associated antigen passage2022
- Author(s)
  Meiko Kimura, Tomoaki Ando, Saaya Fukase, Moe Matsuzawa, Yasuharu Kume, Kumi Izawa, Ayako Kaitani, Nobuhiro Nakano, Keiko Maeda, Ko Okumura, Akira Murakami, Nobuyuki Ebihara, Jiro Kitaura
- Organizer
  第71回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] シアル化ムチンのヒト杯細胞における発現とアレルゲン粒子に対するゲル被膜作用2022
- Author(s)
  松澤萌, 安藤智暁, 深瀬紗綾, 木村芽以子, 久米泰治, 伊沢久未, 前原明絵, 中野信浩, 松田彰, 奥村康, 村上晶, 北浦次郎, 海老原伸行
- Organizer
  第126回眼科学会総会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] A point mutation of NLRP1 (NLRP1-P1214L), identified in a patient with a rare disease, causes an auto-inflammatory disease through hyper-activation of inflammasome: molecular analysis of the pathophysiology2022
- Author(s)
  Yamamoto Risa, Maehara Akie, Ando Taiki, Yasudo Hiroki, Izawa Kumi, Ando Tomoaki, Kaitani Ayako, Kitaura Jiro
- Organizer
  第54回日本小児感染症学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] NLRP1点変異が肝臓線維化を主徴とする自己炎症性疾患を誘導した症例2021
- Author(s)
  安東泰希、前原明絵、安戸裕貴、安藤智暁、伊沢久未、田辺篤、貝谷綾子、亀井杏菜、王合興、金子順一、山路健、奥村康、小川誠司、田村直人、北浦次郎
- Organizer
  第49回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Physiological expression of St6galnac1 protects mice from allergic conjunctivitis.2021
- Author(s)
  Tomoaki Ando, Moe Matsuzawa, Saaya Fukase, Meiko Kimura, Kumi Izawa, Ayako Kaitani, Nobuhiro Nakano, Keiko Maeda, Ko Okumura, Akira Murakami, Nobuyuki Ebihara, Jiro Kitaura.
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] アレルギー疾患の病態生理最前線、ペア型免疫受容体によるアレルギー疾患の制御メカニズム2021
- Author(s)
  伊沢久未、北浦次郎
- Organizer
  第7回総合アレルギー講習会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] 肝臓線維化を主徴とする希少疾患患者から同定されたNLRP1変異の機能解析2021
- Author(s)
  安東泰希、前原明絵、安戸裕貴、安藤智暁、伊沢久未、田辺篤、貝谷綾子、亀井杏菜、王合興、金子順一、山路健、奥村康、小川誠司、田村直人、北浦次郎
- Organizer
  第58回日本消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] 結膜におけるシアル化酵素の生理的発現がアレルギー性結膜炎の発症を抑制する2021
- Author(s)
  松澤萌, 安藤智暁, 深瀬紗綾, 木村芽以子, 伊沢久未, 貝谷綾子, 中野信浩, 前田啓子, 奥村康, 村上晶, 北浦次郎, 海老原伸行
- Organizer
  第125回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] 肝臓線維化を主徴とする稀少疾患患者から同定されたNLRP1変異の機能解析2021
- Author(s)
  安東泰希、前原明絵、安藤智暁、伊沢久未、北浦次郎、田村直人
- Organizer
  第118回日本内科学会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Staphylococcus aureus d-toxin in skin promotes the development of food allergy following epicutaneous sensitization.2021
- Author(s)
  Anna Kamei, Hiromichi Yamada, Kumi Izawa, Tomoaki Ando, Ayako Kaitani, Akie Maehara, Hexing Wang, Koji Tokushige, Shino Uchida, Nobuhiro Nakano, Ko Okumura, Jiro Kitaura.
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] A point mutation within the function-to-find domain (FIIND) of human NLRP1 causes an autoinflammatory disease involving liver fibrosis and dyskeratosis.2021
- Author(s)
  Akie Maehara, Taiki Ando, Kumi Izawa, Tomoaki Ando, Ayako Kaitani, Anna Kamei, Hexing Wang, Koji Tokushige, Nobuhiro Nakano, Naoto Tamura, Ko Okumura, Jiro Kitaura.
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Pollen shells and soluble components play non-redundant roles in the development of allergic conjunctivitis.2021
- Author(s)
  Saaya Fukase, Tomoaki Ando, Moe Matsuzawa, Meiko Kimura, Kumi Izawa, Ayako Kaitani, Anna Kamei, Goukyo Ou, Nobuhiro Nakano, Ko Okumura, Akira Murakami, Nobuyuki Ebihara, Jiro Kitaura.
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] CD300f suppresses IgE- and mast cell-dependent allergic rhinitis.2021
- Author(s)
  Ayako Kaitani, Takuma Ide, Kumi Izawa, Anna Kamei, Tomoaki Ando, Akie Maehara, Hexing Wang, Koji Tokushige, Maeda Keiko, Nobuhiro Nakano, Ko Okumura, Jiro Kitaura.
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] 結膜におけるシアル化酵素St6galnac1の生理的発現がアレルギー性結膜炎の発症を抑制する2021
- Author(s)
  松澤萌、安藤智暁、深瀬紗綾、木村芽以子、伊沢久未、貝谷綾子、中野信浩、前田啓子、奥村康、村上晶、海老原伸行、北浦次郎
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] マウス花粉性結膜炎モデルの発症における花粉の粒子性と抽出成分の重要性2021
- Author(s)
  深瀬紗綾, 安藤智暁, 松澤萌, 木村芽以子, 伊沢久未, 貝谷綾子, 亀井杏菜, 王合興,中野信浩, 奥村康, 村上晶, 北浦次郎, 海老原伸行
- Organizer
  第125回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Differential lipid recognition by mouse versus human CD300f, inhibiting IgE- and mast cell-dependent anaphylaxis, depends on a single amino acid substitution in its immunoglobulin-like domain.2020
- Author(s)
  Ayako Kaitani, Kumi Izawa, Tomoaki Ando, Akie Maehara, Enzhi Yin, Moe Matsuzawa, Taiki Ando, Takuma Ide, Yoko Okamoto, Saaya Fukase, Mayuki Kojima, Anna Kamei, Hexing Wang, Ko Okumura, Jiro Kitaura
- Organizer
  JSA/WAO Joint Congress 2020 (Web)（国際学会）
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Topical administration of particulate pollens induces IL-33- and mast cell-dependent eosinophilic conjunctivitis in mice.2020
- Author(s)
  Tomoaki Ando, Saaya Fukase, Moe Matsuzawa, Ayako Kaitani, Kumi Izawa, Ko Okumura, Akira Murakami, Nobuyuki Ebihara, Jiro Kitaura
- Organizer
  JSA/WAO Joint Congress 2020 (Web)（国際学会）
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] 肝臓線維化を主徴とする希少疾患患者から同定されたNLRP1変異によるインフラマソームの活性化亢進2020
- Author(s)
  安東泰希、前原明絵、安藤智暁、伊沢久未、貝谷綾子、北浦次郎、田村直人
- Organizer
  第48回日本臨床免疫学会総会（Web開催）
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Establishment of sustained unresponsiveness to food allergens by oral immunotherapy is prevented by inhibition of Notch signaling.2020
- Author(s)
  Nobuhiro Nakano, Toshiyuki Yoneyama, Mutsuko Hara, Hiromichi Yamada, Kumi Izawa, Koichiro Uchida, Ayako Kaitani, Tomoaki Ando, Jiro Kitaura, Yoshikazu Ohtsuka, Toshiaki Shimizu, Hideoki Ogawa, Ko Okumura
- Organizer
  JSA/WAO Joint Congress 2020 (Web)（国際学会）
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] NLRP1変異による自己炎症性疾患2020
- Author(s)
  安東泰希、前原明絵、安藤智暁、伊沢久未、貝谷綾子、北浦次郎、田村直人
- Organizer
  第5回ORENCIA Rising Seminar（Zoom配信）（招待講演）
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] 「免疫アレルギー疾患の克服に向けた新しい創薬ターゲット」　抑制型受容体 CD300fによる即時型アレルギーの抑制機序2020
- Author(s)
  伊沢久未，北浦次郎
- Organizer
  第138回薬理学会近畿部会シンポジウム 1 オンライン開催（招待講演）
- Invited
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] マウス結膜杯細胞由来ムチンにおけるシアル化状態の系統差2020
- Author(s)
  松澤萌, 安藤智暁, 貝谷綾子, 伊沢久未, 北浦次郎, 深瀬紗綾, 海老原伸行, 村上晶
- Organizer
  第124回日本眼科学会総会（Web開催）
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Differential lipid recognition by mouse vs human CD300f, inhibiting IgE-mediated anaphylaxis, depends on a single amino acid substitution.2020
- Author(s)
  Ayako Kaitani, Kumi Izawa, Tomoaki Ando, Akie Maehara, Moe Matsuzawa, Taiki Ando, Takuma Ide, Yoko Okamoto, Saaya Fukase, Mayuki Kojima, Anna Kamei, Meiko Kimura, Hexing Wang, Ko Okumura, Jiro Kitaura
- Organizer
  日本研究皮膚科学会第45回年次学術大会・総会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Exaggerated inflammasome activation by a novel NLRP1 mutant derived from a rare disease with severe liver fibrosis2019
- Author(s)
  Taiki Ando, Akie Maehara, Tomoaki Ando, Kumi Izawa, Ayako Kaitani, Enzhi Yin, Takuma Ide, Keiko Maeda, Nobuhiro Nakano, Naoto Tamura, Ko Okumura, Jiro Kitaura
- Organizer
  第48回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] 経皮感作による食物アレルギーの病態メカニズム2019
- Author(s)
  山田啓迪、米山俊之、貝谷綾子、伊沢久未、安藤智暁、北浦次郎、奥村康、清水俊明
- Organizer
  第43回日本小児皮膚科学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] ペア型免疫受容体CD300によるマスト細胞のFceRIシグナル制御機構の解明2019
- Author(s)
  伊沢久未
- Organizer
  第48回日本免疫学会（日本免役学会研究奨励賞ポスター）
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] IgE- and mast cell-dependent anaphylactic responses are regulated by the CD300-lipid axis2019
- Author(s)
  Jiro Kitaura, Kumi Izawa, Ayako Kaitani, Akie Maehara, Tomoaki Ando, Ko Okumura
- Organizer
  第48回日本免疫学会 JSA-JSI Joint Session:アレルギー研究の原点と未来
- Invited
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] マウス及びヒトの免疫受容体 CD300f による脂質認識の違いは免疫グロブリン様ドメインの一アミノ酸変異に依存する2019
- Author(s)
  伊沢久未、貝谷綾子、奥村康、北浦次郎
- Organizer
  第12回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Mast cell- and IgE-dependent anaphylaxis is regulated by the interaction between inhibitory LMIR3/activating LMIR7 and specific lipids2019
- Author(s)
  Kumi Izawa, Ayako Kaitani, Tomoaki Ando, Akie Maehara, Takuma Ide, Moe Matsuzawa, Saaya Fukase, Anna Kamei, Taiki Ando, Nobuhiro Nakano, Ko Okumura Jiro Kitaura
- Organizer
  第48回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] 喘息の病態形成における抑制型受容体CD300fの役割2019
- Author(s)
  貝谷綾子、伊沢久未、安藤智暁、前原明絵、奥村康、北浦次郎
- Organizer
  第68回日本アレルギー学会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Identification of inhibitory mechanisms in pseudo-allergy involving Mrgprb2/MRGPRX2-mediated mast cell activation2019
- Author(s)
  Yoko Okamoto, Ayako Takamori, Kumi Izawa, Tomoaki Ando, Ayako Kaitani, Akie Maehara, Enzhi Yin, Hiromichi Yamada, Hexing Wang, Nobuhiro Nakano, Ko Okumura, Jiro Kitaura
- Organizer
  第48回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] 肝臓線維化を主徴とする稀少疾患患者から同定されたNLRP1変異の機能解析2019
- Author(s)
  安東泰希、前原明絵、安藤智暁、伊沢久未、北浦次郎、田村直人
- Organizer
  第34回自己免疫研究会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Ceramide-CD300f interaction inhibits Mrgprb2-mediated pseudo-allergic drug reactions in mice2019
- Author(s)
  伊沢久未、高森絢子、貝谷綾子、安藤智暁、前原明絵、奥村康、北浦次郎
- Organizer
  第68回日本アレルギー学会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] An inhibitory receptor CD300f inhibits the pathogenesis of OVA-induced food allergy in mice2019
- Author(s)
  Anna Kamei, Shino Uchida, Hiromichi Yamada, Kumi Izawa, Tomoaki Ando, Naoko Negishi, Akie Maehara, Ayako Kaitani, Yoko Okamoto, Nobuhiro Nakano, Ko Okumura, Jiro Kitaura
- Organizer
  第48回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Differential lipid recognition by mouse versus human CD300f, inhibiting IgE-mediated mast cell activation, depends on a single amino acid substitution in its immunoglobulin-like domain2019
- Author(s)
  Ayako Kaitani, Kumi Izawa, Tomoaki Ando, Akie Maehara, Enzhi Yin, Moe Matsuzawa, Saaya Fukase, Hexing Wang, Keiko Maeda, Nobuhiro Nakano, Ko Okumura, Jiro Kitaura
- Organizer
  第48回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K08782
[Presentation] Phytosphingosine-CD300b interaction promotes zymosan-induced nitric oxide-dependent neutrophil recruitment.2018
- Author(s)
  Kumi Izawa, Mariko Takahashi, Ayako Kaitani, Akie Maehara, Tomoaki Ando, Atsushi Tanabe, Ko Okumura, Toshio Kitamura, Jiro Kitaura.
- Organizer
  第47回日本免疫学会
- Data Source
  KAKENHI-PROJECT-17K16352
[Presentation] An inhivitory receptor CD300f suppresses the development of food allergy.2018
- Author(s)
  Shino Uchida, Kumi Izawa, Koichiro Uchida, Naoko Negishi, Akie Maehara, Ayako Kaitani, Tomoaki Ando, Nobuhiro Nakano, Ko Okumura, Jiro Kitaura.
- Organizer
  第47回日本免疫学会
- Data Source
  KAKENHI-PROJECT-17K16352
[Presentation] ザイモサンによる好中球集積・炎症メカニズムの解明：NO産生樹状細胞におけるCD300bの役割2018
- Author(s)
  伊沢久未，高森絢子，貝谷綾子，内田志野，奥村康，北浦次郎
- Organizer
  第67回日本アレルギー学会
- Data Source
  KAKENHI-PROJECT-17K16352
[Presentation] The role of CD300f in the development of asthma.2018
- Author(s)
  Ayako Kaitani, Kumi Izawa, Tomoaki Ando, Akie Maehara, Atsushi Tanabe, Keiko Maeda, Novuhiro Nakano, Ko Okumura, Jiro Kitaura.
- Organizer
  第47回日本免疫学会
- Data Source
  KAKENHI-PROJECT-17K16352
[Presentation] NO産生樹状細胞に発現するCD300bは脂質フィトスフィンゴシンを認識してザイモサン投与による好中球集積・関節炎を促進する2018
- Author(s)
  伊沢久未,　高橋まり子,　貝谷綾子,　前原明絵,　安藤智暁,　北村俊雄,　奥村康,　北浦次郎
- Organizer
  第46回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-17K16352
[Presentation] CD300f suppresses neutrophil recruitment to LPS-injected skin: A role of CD300f in gram-negative bacterial skin infections?2018
- Author(s)
  Ayako Kaitani, Kumi Izawa, Ayako Takamori, Shino Uchida, Ko Okumura, Jiro Kitaura.
- Organizer
  第67回日本アレルギー学会
- Data Source
  KAKENHI-PROJECT-17K16352
[Presentation] A novel mutation of NLRP1 is involved in the pathogenesis of a rare disease with severe liver fibrosis.2018
- Author(s)
  Taiki Ando, Akie Maehara, Tomoaki Ando, Kumi, Izawa, Ayako Kaitani, Atsushi Tanabe, Keiko Maeda, Novuhiro Nakano, Naoto Tamura, Ko Okumura, Jiro Kitaura.
- Organizer
  第47回日本免疫学会
- Data Source
  KAKENHI-PROJECT-17K16352
[Presentation] Identification and characterization of a novel mutation of NLRP1 in a patient with a rare disease involving severe liver fibrosis.2018
- Author(s)
  Akie Maehara, Hiroki Yasudo, Atsushi Tanabe, Tomoaki Ando, Kumi Izawa, Ayako Kaitani, Ayako Takamori, Shino Uchida, Keiko Maeda, Nobuhiro Nakano, Ko Okumura, Jiro Kitaura.
- Organizer
  Australia-Japan Meeting on Cell Death.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16352
[Presentation] Identification and characterization of a novel mutation of NLRP1 in a patient with a rare disease involving severe liver fibrosis2017
- Author(s)
  Akie Maehara, Atsushi Tanabe, Tomoaki Ando, Kumi Izawa, Ayako Kaitani, Ayako Takamori, Shino Uchida, Keiko Maeda, Nobuhiro Nakano, Ko Okumura, Jiro Kitaura
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16352
[Presentation] セラミドとLMIR3の結合はLPSにより誘導される皮膚炎症を抑制する2017
- Author(s)
  伊沢久未、高森絢子、奥村康、北浦次郎
- Organizer
  第66回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-17K16352
[Presentation] LMIR3はマスト細胞を介するIgE非依存的な薬剤アレルギーを抑制する2017
- Author(s)
  高森絢子、伊沢久未、奥村康、北浦次郎
- Organizer
  第66回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-17K16352
[Presentation] Mast cell- and IgE-dependent anaphylaxis is regulated by paired receptors LMIR3 and LMIR72017
- Author(s)
  Kumi Izawa, Akie Maehara, Ayako Kaitani, Ayako Takamori, Shino Uchida, Masamichi Isobe, Tomoaki Ando, Keiko Maeda, Nobuhiro Nakano, Ko Okumura, Toshio Kitamura, Jiro Kitaura
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16352
[Presentation] A critical role of an inhibitory receptor LMIR3 in the pathogenesis of food allergy2017
- Author(s)
  Shino Uchida, Kumi Izawa, Koichiro Uchida, Naoko Negishi, Akie Maehara, Ayako Kaitani, Ayako Takamori, Tomoaki Ando, Nobuhiro Nakano, Toshio Kitamura, Ko Okumura, Jiro Kitaura
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16352
[Presentation] CD300f suppresses neutrophil recruitment to LPS-injected skin: A role of CD300f in gram-negative bacterial skin infections2017
- Author(s)
  Ayako Kaitani, Kumi Izawa, Akie Maehara, Ayako Takamori, Shino Uchida, Atsushi Tanabe, Tomoaki Ando, Keiko Maeda, Nobuhiro Nakano, Ko Okumura, Toshio Kitamura, Jiro Kitaura
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16352
[Presentation] 抑制型受容体CD300fとアレルギー疾患2017
- Author(s)
  北浦次郎、伊沢久未、奥村康
- Organizer
  第19回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-17K16352
[Presentation] Ceramide-CD300f interaction inhibits Mrgprb2-mediated mast cell activation and pseudo-allergic drug reactions in mice2017
- Author(s)
  Ayako Takamori, Kumi Izawa, Akie Maehara, Ayako Kaitani, Shino Uchida, Atsushi Tanabe, Tomoaki Ando, Keiko Maeda, Nobuhiro Nakano, Toshio Kitamura, Ko Okumura, Jiro Kitaura
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16352
[Presentation] The role of leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 in plasmacytoid dendritic cell (pDC)2016
- Author(s)
  Kaitani Ayako, Izawa Kumi, Maehara Akie, Isobe Masamichi, Takamori Ayako, Uchida Shino, Nakano Nobuhiro, Maeda Keiko, Ando Tomoaki, Okumura Ko, Kitamura Toshio, Kitaura Jiro
- Organizer
  第45回日本免疫学会
- Place of Presentation
  Okinawa Convention Center・Laguna Garden Hotel
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K19677
[Presentation] 敗血症性腹膜炎におけるセラミド-CD300fシグナルの役割2016
- Author(s)
  伊沢久未、奥村康、北浦次郎
- Organizer
  第９回セラミド研究会学術集会
- Place of Presentation
  東京ユビキタス協創広場CANVAS
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-15K19677
[Presentation] A critical role of ceramide-CD300f interaction in septic peritonitis.2016
- Author(s)
  Izawa Kumi, Maehara Akie, Isobe Masamichi, Kaitani Ayako, Nakano Nobuhiro, Maeda Keiko, Takamori Ayako, Okumura Ko, Kitamura Toshio, Kitaura Jiro
- Organizer
  第45回日本免疫学会
- Place of Presentation
  Okinawa Convention Center・Laguna Garden Hotel
- Year and Date
  2016-12-06
- Data Source
  KAKENHI-PROJECT-15K19677
[Presentation] マスト細胞に発現する活性化型受容体LMIR7のアレルギー反応にける役割2016
- Author(s)
  伊沢久未、奥村康、北村俊雄、北浦次郎
- Organizer
  第65回日本アレルギー学会学術大会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K19677
[Presentation] The novel role of LMIR7/CLM-3 in mast cell- and　IgE-dependent anaphylaxis2015
- Author(s)
  磯部優理、伊沢久未、前原明絵、松川敏大、貝谷綾子、奥村康、北村俊雄、北浦次郎
- Organizer
  日本免疫学会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K19677
[Presentation] Disripting ceramide-LMIR3 interaction prevents bacterial sepsis by stimulating neutrophil recruitment2015
- Author(s)
  伊沢久未、磯部優理、奥村康、北村俊雄、北浦次郎
- Organizer
  日本臨床免疫学会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-15K19677
[Presentation] マウスおよびヒトLMIR3のリガンド同定と機能解析2015
- Author(s)
  伊沢久未、奥村康、北村俊雄、北浦次郎
- Organizer
  日本アレルギー学会
- Place of Presentation
  グランドプリンスホテル新高輪
- Year and Date
  2015-05-26
- Data Source
  KAKENHI-PROJECT-15K19677
[Presentation] Disrupting ceramide-LMIR3 interaction prevents bacterial sepsis by stimulating neutrophil recruitment2014
- Author(s)
  IZAWA Kumi, ISOBE Masamichi, MATSUKAWA Toshihiro, MAEHARA Akie, TAKAHASHI Mariko, KAITANI Ayako, OKUMURA Ko, KITAMURA Toshio, KITAURA Jiro
- Organizer
  第43回日本免疫学会・学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-25893050
[Presentation] Soluble form of TIM-4 regulates mast cell activation by binding to LMIR5 and TIM-3.2013
- Author(s)
  Kamachi Fumitaka, Harada Norihiro, Nishiyama Chiharu, Izawa Kumi, Kitaura Jiro, Okumura Ko, Miyake Sachiko, Akiba Hisaya
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-25893050
[Presentation] Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast cell activation.2013
- Author(s)
  Izawa Kumi, Isobe Masamichi, Matsukawa Toshihiro, Maehara Akie, Yamanishi Yoshinori, Takahashi Mariko, Kaitani Ayako, Okumura Ko, Kitamura Toshio, Kitaura Jiro
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-25893050

1. INUI Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. KINJO Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 安藤智暁

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
4. 貝谷綾子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 北浦次郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
6. 中野信浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 北村俊雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 高塚翔吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IZAWA KUMI 伊沢 久未

IZAWA Kumi 伊沢 久未

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanisms by which an inhibitory receptor regulates the development of autoimmune subepidermal bullous diseasesPrincipal Investigator

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Elucidation of control mechanism of skin inflammatory diseases involving TLRsPrincipal Investigator

Principal Investigator

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Functional analysis of an inhibitory receptor LMIR3 in basophil activation and Th2-type immune responsesPrincipal Investigator

Principal Investigator

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Research Institution

Functional analysis of human LMIR3/CD300FPrincipal Investigator

Principal Investigator

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[Book] 炎症と免疫2014

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[Book] 臨床免疫・アレルギー科2013

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[Book] 生化学2013

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[Book] 臨床免疫・アレルギー科2013

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[Journal Article] The protective role of conjunctival goblet cell mucin sialylation2023

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[Journal Article] Mucosal Mast Cell-Specific Gene Expression Is Promoted by Interdependent Action of Notch and TGF-β Signaling.2022

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[Journal Article] Development of mouse model for oral allergy syndrome to identify IgE cross-reactive pollen and food allergens: ragweed pollen cross-reacts with fennel and black pepper2022

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[Journal Article] ペア型免疫受容体とアレルギー疾患2022

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[Journal Article] A possible association between a novel NLRP1 mutation and an autoinflammatory disease involving liver cirrhosis2021

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[Journal Article] Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy.2021

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[Journal Article] Pollen shells and soluble factors play non-redundant roles in the development of allergic conjunctivitis in mice2021

Author(s)

IZAWA KUMI 伊沢久未

IZAWA Kumi 伊沢久未