Takahashi Kenta 高橋健太

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高橋健太タカハシケンタ

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Researcher Number	80711689
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所感染病理部, 主任研究員
Affiliation (based on the past Project Information) *help	2018 – 2023: 国立感染症研究所, 感染病理部, 主任研究官 2016: 国立感染症研究所, 感染病理部, 研究員 2016: 国立感染症研究所, 感染病理部, 研究官 2014 – 2015: 国立感染症研究所, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 49060:Virology-related / Experimental pathology
Keywords	Principal Investigator JCウイルス / 進行性多巣性白質脳症 / JCポリオーマウイルス / マイクロRNA / 組織形態 / In situ hybridization / quasi-species / 次世代シークエンサー / T抗原

ウイルス由来マイクロRNAに着目した進行性多巣性白質脳症の新規診断法と治療法開発Principal Investigator
- Principal Investigator
  
  高橋健太
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Institute of Infectious Diseases
Pathological diagnosis targeting JC polyomavirus-encoded microRNAs in progressive multifocal leukoencephalopathy tissues and its repressive role in virus replicationPrincipal Investigator
- Principal Investigator
  
  Takahashi Kenta
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  National Institute of Infectious Diseases
Deep-sequence identification and role in virus replication of a JC virus quasispecies in patients with progressive multifocal leukoencephalopathyPrincipal Investigator
- Principal Investigator
  
  Takahashi Kenta
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  National Institute of Infectious Diseases

All 2024 2023 2022 2021 2020 2019 2017 2016 2015 Other

All Journal Article Presentation Book

[Book] 神経内科 clinical questions and pearls 「神経感染症」, 神経感染症の病理2017
- Author(s)
  高橋健太, 片野晴隆, 長谷川秀樹
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-26860270
[Journal Article] <sup>18</sup>F-THK5351 Positron Emission Tomography Clearly Depicted Progressive Multifocal Leukoencephalopathy after Mantle Cell Lymphoma Treatment2024
- Author(s)
  Chiba Yuta、Kawakita Rie、Mitamura Katsuya、Takahashi Kenta、Suzuki Tadaki、Nakamichi Kazuo、Suzuki Kenta、Morishita Asahiro、Kobara Hideki、Deguchi Kazushi、Masaki Tsutomu
- Journal Title
  
  Intern. Med.
  
  Volume: 63 Issue: 16 Pages: 2325-2329
- DOI
  10.2169/internalmedicine.3023-23
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2024-08-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07450, KAKENHI-PROJECT-22K07361
[Journal Article] BK polyomavirus-associated urothelial carcinoma of the bladder with a background of BK polyomavirus nephropathy in a kidney transplant recipient．2023
- Author(s)
  Sari Iwasaki, Kenta Takahashi, Harutaka Katano, Tadaki Suzuki, Hajime Sasaki, Hiroshi Harada, Yusuke Takada, Keishi Makita, Yuichiro Fukasawa, Takahiro Tsuji．
- Journal Title
  
  Nephron
  
  Volume: 147(suppl 1) Issue: Suppl. 1 Pages: 53-60
- DOI
  10.1159/000531822
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07361, KAKENHI-PROJECT-22K20908
[Journal Article] Nationwide Laboratory Surveillance of Progressive Multifocal Leukoencephalopathy in Japan: Fiscal Years 2011?20202023
- Author(s)
  Nakamichi Kazuo、Miura Yoshiharu、Shimokawa Toshio、Takahashi Kenta、Suzuki Tadaki、Funata Nobuaki、Harada Masafumi、Mori Koichiro、Sanjo Nobuo、Yukitake Motohiro、Takahashi Kazuya、Hamaguchi Tsuyoshi、Izaki Shoko、Oji Satoru、Nakahara Jin、Ae Ryusuke、Kosami Koki、et al.
- Journal Title
  
  Viruses
  
  Volume: 15 Issue: 4 Pages: 968-968
- DOI
  10.3390/v15040968
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07450, KAKENHI-PROJECT-22K07361
[Journal Article] 進行性多巣性白質脳症2023
- Author(s)
  高橋健太，鈴木忠樹
- Journal Title
  
  病理と臨床第41巻臨時増刊号病理診断クイックリファレンス2023
  
  Volume: 41 Pages: 331-331
- Data Source
  KAKENHI-PROJECT-22K07361
[Journal Article] A human T-lymphotropic virus-1 carrier who developed progressive multifocal leukoencephalopathy following immunotherapy for sarcoidosis: a case report2023
- Author(s)
  Nagahori Takashi、Shiraishi Wataru、Nishikawa Masafumi、Matsuyoshi Ayano、Ogura Takenori、Yamada Yui、Takahashi Kenta、Suzuki Tadaki、Nakamichi Kazuo、Hashimoto Tetsuya、Hatano Taketo
- Journal Title
  
  BMC Neurology
  
  Volume: 23 Issue: 1 Pages: 52-52
- DOI
  10.1186/s12883-023-03094-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07450, KAKENHI-PROJECT-22K07361
[Journal Article] 中枢神経系感染症の病理検査2023
- Author(s)
  高橋健太
- Journal Title
  
  臨床検査
  
  Volume: 67(12) Pages: 1378-86
- Data Source
  KAKENHI-PROJECT-22K07361
[Journal Article] Successful treatment of progressive multifocal leukoencephalopathy that developed 21 years after renal transplantation: A case report2022
- Author(s)
  Negishi Nao、Ikeguchi Ryotaro、So Hayato、Kobayashi Masaki、Nitta Masayuki、Masui Keita、Nakamichi Kazuo、Takahashi Kenta、Ishida Hideki、Kawamata Takakazu、Shibata Noriyuki、Shimizu Yuko、Kitagawa Kazuo
- Journal Title
  
  Neuroimmunology Reports
  
  Volume: 2 Pages: 100113-100113
- DOI
  10.1016/j.nerep.2022.100113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07450, KAKENHI-PROJECT-22K07361, KAKENHI-PROJECT-22K07505, KAKENHI-PROJECT-18K15174
[Journal Article] “Burnt‐out” progressive multifocal leukoencephalopathy in idiopathic <scp>CD4</scp> <sup>+</sup> lymphocytopenia2021
- Author(s)
  Fukumoto Tatsuya、Sakashita Yasuhiro、Katada Fumiaki、Takeuchi Ryoko、Miyamoto Ryosuke、Izumi Yuishin、Sato Susumu、Shibayama Hidehiro、Takahashi Kenta、Suzuki Tadaki、Nakamichi Kazuo、Murayama Shigeo、Fukutake Toshio
- Journal Title
  
  Neuropathology
  
  Volume: 41 Issue: 6 Pages: 484-488
- DOI
  10.1111/neup.12773
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07450, KAKENHI-PROJECT-18K15174
[Journal Article] Infratentorial onset of progressive multifocal leukoencephalopathy in a patient with systematic lupus erythematosus complicated with lymphoma: a case report2021
- Author(s)
  Sakuraba Mita、Watanabe Shinji、Nishiyama Yasuhiro、Takahashi Kenta、Nakamichi Kazuo、Suzuki Mikito、Nawata Takashi、Komai Kota、Gono Takahisa、Takeno Mitsuhiro、Suzuki Tadaki、Kimura Kazumi、Kuwana Masataka
- Journal Title
  
  Modern Rheumatology Case Reports
  
  Volume: 5 Issue: 2 Pages: 272-277
- DOI
  10.1080/24725625.2021.1899763
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07450, KAKENHI-PROJECT-18K15174
[Journal Article] 神経感染症の病理2021
- Author(s)
  高橋健太, 鈴木忠樹
- Journal Title
  
  医学のあゆみ脳・神経系の感染症診断と治療の最前線
  
  Volume: 第277巻・第1号 Pages: 4-9
- Data Source
  KAKENHI-PROJECT-18K15174
[Journal Article] 症例報告脳脊髄液中のJCV-DNA遺伝子検査が2回とも陰性であったが,開頭脳生検で診断確定したHIV関連進行性多巣性白質脳症の1例2020
- Author(s)
  Kitazaki Y, Iwasaki H, Kitai R, Takahashi K, Nakamichi K, Hamano T.
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 72 Issue: 5 Pages: 541-546
- DOI
  10.11477/mf.1416201559
- NAID
  40022256118
- ISSN
  1344-8129, 1881-6096
- Year and Date
  2020-05-01
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07909, KAKENHI-PROJECT-18K15174
[Journal Article] 中枢神経感染症の病理2020
- Author(s)
  高橋健太, 鈴木忠樹, 片野晴隆, 長谷川秀樹
- Journal Title
  
  NEUROINFECTION
  
  Volume: 25 Pages: 125-132
- NAID
  130007841901
- Data Source
  KAKENHI-PROJECT-18K15174
[Journal Article] Progressive multifocal leukoencephalopathy in a patient with primary amyloid light-chain amyloidosis2020
- Author(s)
  Katsuse Kazuto、Akiyama Kaho、Ishida Tadao、Kitayama Chigusa、Ishibashi Yoshitaka、Ochi Mieko、Kumasaka Toshio、Takahashi Kenta、Suzuki Tadaki、Nakamichi Kazuo、Saijo Masayuki、Hashida Hideji
- Journal Title
  
  Clinical Neurology and Neurosurgery
  
  Volume: 192 Pages: 105709-105709
- DOI
  10.1016/j.clineuro.2020.105709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15174, KAKENHI-PROJECT-17K09768
[Journal Article] Lenalidomide‐associated progressive multifocal leukoencephalopathy2020
- Author(s)
  Kazutaka Nishimura, Yuta Iwai, Mariko Yabuki, Hiroe Fuse, Kazuo Nakamichi, Kenta Takahashi, Tadaki Suzuki, Msayuki Saijo, Takeshi Fukushima, Satoshi Kuwabara
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: 12 Pages: 63-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15174
[Journal Article] High expression of JC polyomavirus-encoded microRNAs in progressive multifocal leukoencephalopathy tissues and its repressive role in virus replication2020
- Author(s)
  Takahashi K, Sato Y, Sekizuka T, Kuroda M, Suzuki T, Hasegawa H, Katano H.
- Journal Title
  
  PLOS Pathogens
  
  Volume: 16 Issue: 4 Pages: e1008523-e1008523
- DOI
  10.1371/journal.ppat.1008523
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07600, KAKENHI-PROJECT-18K15174
[Journal Article] Brain Biopsy Is More Reliable than the DNA test for JC Virus in Cerebrospinal Fluid for the Diagnosis of Progressive Multifocal Leukoencephalopathy2017
- Author(s)
  Junji Ikeda, Akira Matsushima, Wataru Ishii, Tetuya Goto, Kenta Takahashi, Kazuo Nakamichi, Masayuki Saijo, Yoshiki Sekijima, Shu-ichi Ikeda
- Journal Title
  
  Intern. Med.
  
  Volume: 56 Issue: 10 Pages: 1231-1234
- DOI
  10.2169/internalmedicine.56.7689
- NAID
  130006857284
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860270
[Journal Article] Deep-sequence Identification and Role in Virus Replication of a JC Virus Quasispecies in Patients with Progressive Multifocal Leukoencephalopathy2017
- Author(s)
  Kenta Takahashi, Tsuyoshi Sekizuka, Hitomi Fukumoto, Kazuo Nakamichi, Tadaki Suzuki, Yuko Sato, Hideki Hasegawa, Makoto Kuroda, Harutaka Katano
- Journal Title
  
  Journal of Virology
  
  Volume: 91(1) Issue: 1
- DOI
  10.1128/jvi.01335-16
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860270, KAKENHI-PROJECT-26860307
[Presentation] 低IgM血症, 間質性肺炎, SLEを合併し, メフロキン, ミルタザピン, ヒドロキシクロロキンが有効であったPMLの1例2022
- Author(s)
  増田優介, 銭谷怜史, 松田隼弥, 船田信顕, 枝川俊二, 三ツ矢幸一, 高橋健太, 鈴木忠樹, 中道一生, 三浦義治
- Organizer
  第26回日本神経感染症学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-22K07361
[Presentation] 低IgM血症, 間質性肺炎, SLEを合併し, メフロキン, ミルタザピン, ヒドロキシクロロキンが有効であったPMLの1例2022
- Author(s)
  増田優介, 銭谷怜史, 松田隼弥, 船田信顕, 枝川俊二, 三ツ矢幸一, 高橋健太, 鈴木忠樹, 中道一生, 三浦義治
- Organizer
  第26回日本神経感染症学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-18K15174
[Presentation] 進行性多巣性白質脳症組織におけるJCポリオーマウイルスが産生するマイクロRNAの解析2021
- Author(s)
  高橋健太, 佐藤由子, 関塚剛史, 黒田誠, 鈴木忠樹, 長谷川秀樹, 片野晴隆
- Organizer
  第110回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K15174
[Presentation] JCウイルスがコードするマイクロRNAの機能と病理診断法への応用2021
- Author(s)
  鈴木忠樹, 高橋健太, 片野晴隆
- Organizer
  第25回日本神経感染症学会総会学術集会
- Data Source
  KAKENHI-PROJECT-18K15174
[Presentation] JC polyomavirus-encoded microRNAs in progressive multifocal leukoencephalopathy tissues2021
- Author(s)
  Kenta Takahashi, Yuko Sato, Tsuyoshi Sekizuka, Makoto Kuroda, Tadaki Suzuki, Hideki Hasegawa, Harutaka Katano
- Organizer
  第62回日本神経病理学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-18K15174
[Presentation] JCウイルス調節領域配列の再構成を伴う移植腎JCV腎症の1例2019
- Author(s)
  辻隆裕、岩崎沙理、牧田啓史、石立尚路、見附明彦、原田浩、高橋健太、中道一生、深澤雄一郎
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K15174
[Presentation] 中枢神経感染症の病理2019
- Author(s)
  高橋健太
- Organizer
  第24回日本神経感染症学会総会・学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K15174
[Presentation] Deep-sequence identification and role in virus replication of a JCV quasispecies in PML patients2017
- Author(s)
  Kenta Takahashi, Tsuyoshi Sekizuka, Hitomi Fukumoto, Kazuo Nakamichi, Tadaki Suzuki, Yuko Sato, Hideki Hasegawa, Makoto Kuroda, Harutaka Katano.
- Organizer
  第106回日本病理学会総会
- Place of Presentation
  東京, 京王プラザホテル
- Year and Date
  2017-04-27
- Data Source
  KAKENHI-PROJECT-26860270
[Presentation] 次世代シークエンサーが明らかにしたJCウイルスのゲノム変異とPMLの病態2017
- Author(s)
  高橋健太, 関塚剛史, 福本瞳, 中道一生, 鈴木忠樹, 佐藤由子, 長谷川秀樹, 黒田誠, 片野晴隆
- Organizer
  第58回日本神経病理学会総会学術研究会
- Place of Presentation
  東京, 学術総合センター
- Year and Date
  2017-06-01
- Data Source
  KAKENHI-PROJECT-26860270
[Presentation] 全身性エリテマトーデス加療中に頭部MRIで散在性点状T2高信号病変を呈し進行が見られていない進行性多巣性白質脳症の一例2016
- Author(s)
  石井淳子, 川本未知，藤原悟，船津尭之，今井幸弘, 奴久妻聡一, 高橋健太，中道一生, 幸原伸夫
- Organizer
  第21回日本神経感染症学会総会・学術大会
- Place of Presentation
  金沢, 金沢東急ホテル
- Year and Date
  2016-10-21
- Data Source
  KAKENHI-PROJECT-26860270
[Presentation] 進行性多巣性白質脳症の組織検体における免疫組織化学とウイルス核酸定量による病勢の検討2015
- Author(s)
  高橋健太、鈴木忠樹、佐藤由子、片野晴隆、長谷川秀樹
- Organizer
  第20回日本神経感染症学会総会、学術大会
- Place of Presentation
  ホテルメルパルク長野
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-26860270
[Presentation] 本邦発症の進行性多巣性白質脳症患者サーベイランスの現状と課題 – 厚労科研PML研究班PMLサーベイランス報告 –2015
- Author(s)
  三浦義治、中道一生、岸田修二、西條政幸、高橋健太、鈴木忠樹、三條伸夫、阿江竜介、澤洋文、奴久妻聡一、原由紀子、雪竹基弘、濱口毅、水澤英洋、山田正仁
- Organizer
  第20回日本神経感染症学会総会、学術大会
- Place of Presentation
  ホテルメルパルク長野
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-26860270
[Presentation] 不明脳炎症例の病理組織検体における原因ウイルスの網羅的検索2015
- Author(s)
  高橋健太、福本瞳、鈴木忠樹、佐藤由子、片野晴隆、長谷川秀樹
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-26860270
[Presentation] 脳生検にて確定診断に至ったHIV陽性の進行性多巣性白質脳症の1例2015
- Author(s)
  北崎佑樹、池ヶ谷諭史、北井隆平、高橋健太
- Organizer
  第20回日本神経感染症学会総会、学術大会
- Place of Presentation
  ホテルメルパルク長野
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-26860270
[Presentation] 不明脳炎症例の病理組織検体からの原因ウイルスの網羅的検索
- Author(s)
  高橋健太、福本瞳、鈴木忠樹、佐藤由子、片野晴隆、長谷川秀樹
- Organizer
  第19回日本神経感染症学会
- Place of Presentation
  金沢歌劇座
- Year and Date
  2014-09-04 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-26860270
[Presentation] 不明脳炎症例の臨床検体からの原因ウイルスの網羅的検索
- Author(s)
  高橋健太、福本瞳、鈴木忠樹、佐藤由子、片野晴隆、長谷川秀樹
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26860270
[Presentation] 不明脳炎における原因ウイルスの網羅的検索
- Author(s)
  高橋健太、福本瞳、鈴木忠樹、佐藤由子、片野晴隆、長谷川秀樹
- Organizer
  第55回日本神経病理学会総会学術研究会
- Place of Presentation
  学術総合センター
- Year and Date
  2014-06-05 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-26860270

1. 中道一生

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
2. 片野晴隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Kenta 高橋 健太

高橋 健太 タカハシ ケンタ

Research Projects

Research Products

Co-Researchers

ウイルス由来マイクロRNAに着目した進行性多巣性白質脳症の新規診断法と治療法開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathological diagnosis targeting JC polyomavirus-encoded microRNAs in progressive multifocal leukoencephalopathy tissues and its repressive role in virus replicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Deep-sequence identification and role in virus replication of a JC virus quasispecies in patients with progressive multifocal leukoencephalopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 神経内科 clinical questions and pearls 「神経感染症」, 神経感染症の病理2017

Author(s)

Publisher

Data Source

[Journal Article] <sup>18</sup>F-THK5351 Positron Emission Tomography Clearly Depicted Progressive Multifocal Leukoencephalopathy after Mantle Cell Lymphoma Treatment2024

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ISSN

Year and Date

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[Journal Article] BK polyomavirus-associated urothelial carcinoma of the bladder with a background of BK polyomavirus nephropathy in a kidney transplant recipient．2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nationwide Laboratory Surveillance of Progressive Multifocal Leukoencephalopathy in Japan: Fiscal Years 2011?20202023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 進行性多巣性白質脳症2023

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Data Source

[Journal Article] A human T-lymphotropic virus-1 carrier who developed progressive multifocal leukoencephalopathy following immunotherapy for sarcoidosis: a case report2023

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[Journal Article] 中枢神経系感染症の病理検査2023

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[Journal Article] 症例報告 脳脊髄液中のJCV-DNA遺伝子検査が2回とも陰性であったが,開頭脳生検で診断確定したHIV関連進行性多巣性白質脳症の1例2020

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高橋健太タカハシケンタ

[Journal Article] 症例報告脳脊髄液中のJCV-DNA遺伝子検査が2回とも陰性であったが,開頭脳生検で診断確定したHIV関連進行性多巣性白質脳症の1例2020